locus-tag	class	description
K3X48_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K3X48_RS00040	COG3909	cytochrome
K3X48_RS00045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X48_RS00045	COG2010	Cytochrome c
K3X48_RS00050	COG2132	Multicopper oxidase
K3X48_RS00075	COG0010	Belongs to the arginase family
K3X48_RS00080	COG1166	arginine decarboxylase activity
K3X48_RS00095	COG0010	Belongs to the arginase family
K3X48_RS00100	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K3X48_RS00125	COG0351	phosphomethylpyrimidine kinase
K3X48_RS00135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3X48_RS00150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3X48_RS00155	COG3938	Belongs to the proline racemase family
K3X48_RS00160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X48_RS00165	COG3938	Belongs to the proline racemase family
K3X48_RS00170	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K3X48_RS00175	COG1802	Transcriptional regulator
K3X48_RS00185	COG0028	Belongs to the TPP enzyme family
K3X48_RS00190	COG1349	DNA-binding transcription factor activity
K3X48_RS00205	COG1840	ABC-type Fe3 transport system, periplasmic component
K3X48_RS00210	COG3842	ATPase activity
K3X48_RS00225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K3X48_RS00235	COG1012	belongs to the aldehyde dehydrogenase family
K3X48_RS00250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K3X48_RS00270	COG1283	sodium-dependent phosphate transmembrane transporter activity
K3X48_RS00290	COG0745	RESPONSE REGULATOR receiver
K3X48_RS00295	COG2205	protein histidine kinase activity
K3X48_RS00305	COG1120	ATPase activity
K3X48_RS00315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K3X48_RS00335	COG1132	(ABC) transporter
K3X48_RS00340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K3X48_RS00345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3X48_RS00350	COG1960	acyl-CoA dehydrogenase activity
K3X48_RS00355	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X48_RS00375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K3X48_RS00380	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K3X48_RS00385	COG1335	isochorismatase
K3X48_RS00395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3X48_RS00405	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K3X48_RS00415	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
K3X48_RS00435	COG0514	ATP-dependent DNA helicase (RecQ)
K3X48_RS00440	COG3022	response to hydroperoxide
K3X48_RS00465	COG0604	alcohol dehydrogenase
K3X48_RS00465	COG3321	synthase
K3X48_RS00465	COG1028	Short-chain dehydrogenase reductase Sdr
K3X48_RS00475	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K3X48_RS00480	COG2814	Major facilitator Superfamily
K3X48_RS00490	COG2267	carboxylic ester hydrolase activity
K3X48_RS00500	COG2423	ornithine cyclodeaminase activity
K3X48_RS00525	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K3X48_RS00605	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
K3X48_RS00615	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K3X48_RS00615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X48_RS00620	COG0697	spore germination
K3X48_RS00625	COG0741	lytic transglycosylase activity
K3X48_RS00630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3X48_RS00640	COG1720	tRNA m6t6A37 methyltransferase activity
K3X48_RS00645	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K3X48_RS00650	COG0303	'Molybdopterin
K3X48_RS00655	COG0746	molybdenum cofactor guanylyltransferase activity
K3X48_RS00660	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K3X48_RS00675	COG0583	DNA-binding transcription factor activity
K3X48_RS00715	COG1960	acyl-CoA dehydrogenase activity
K3X48_RS00720	COG0009	L-threonylcarbamoyladenylate synthase
K3X48_RS00725	COG1678	Uncharacterized ACR, COG1678
K3X48_RS00760	COG3119	arylsulfatase activity
K3X48_RS00805	COG0494	nUDIX hydrolase
K3X48_RS00810	COG3034	peptidoglycan biosynthetic process
K3X48_RS00815	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K3X48_RS00830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K3X48_RS00845	COG0328	RNA-DNA hybrid ribonuclease activity
K3X48_RS00855	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K3X48_RS00865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K3X48_RS00870	COG1758	RNA polymerase activity
K3X48_RS00875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K3X48_RS00885	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K3X48_RS00890	COG1280	lysine exporter protein (LysE YggA)
K3X48_RS00895	COG0736	holo-[acyl-carrier-protein] synthase activity
K3X48_RS00900	COG0681	Belongs to the peptidase S26 family
K3X48_RS00905	COG0571	ribonuclease III activity
K3X48_RS00910	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K3X48_RS00920	COG1381	Involved in DNA repair and RecF pathway recombination
K3X48_RS00960	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K3X48_RS00965	COG0745	RESPONSE REGULATOR receiver
K3X48_RS00970	COG2205	protein histidine kinase activity
K3X48_RS00980	COG1660	Displays ATPase and GTPase activities
K3X48_RS00990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K3X48_RS01000	COG0840	transmembrane signaling receptor activity
K3X48_RS01035	COG0300	oxidoreductase activity
K3X48_RS01045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K3X48_RS01055	COG0501	Belongs to the peptidase M48B family
K3X48_RS01060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K3X48_RS01080	COG0250	Participates in transcription elongation, termination and antitermination
K3X48_RS01085	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K3X48_RS01090	COG0081	regulation of translation
K3X48_RS01095	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K3X48_RS01100	COG0222	ribosome binding
K3X48_RS01105	COG0085	RNA polymerase activity
K3X48_RS01110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K3X48_RS01120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K3X48_RS01125	COG0049	tRNA binding
K3X48_RS01130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K3X48_RS01135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K3X48_RS01150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K3X48_RS01155	COG0088	Forms part of the polypeptide exit tunnel
K3X48_RS01160	COG0089	rRNA binding
K3X48_RS01170	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K3X48_RS01175	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K3X48_RS01180	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K3X48_RS01185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K3X48_RS01190	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K3X48_RS01220	COG0255	Belongs to the universal ribosomal protein uL29 family
K3X48_RS01225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K3X48_RS01230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K3X48_RS01235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K3X48_RS01240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K3X48_RS01245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K3X48_RS01250	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K3X48_RS01255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K3X48_RS01260	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K3X48_RS01265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K3X48_RS01270	COG1841	ribosomal large subunit assembly
K3X48_RS01290	COG0200	Binds to the 23S rRNA
K3X48_RS01295	COG0201	protein transport
K3X48_RS01300	COG0563	adenylate kinase activity
K3X48_RS01305	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K3X48_RS01310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K3X48_RS01315	COG0202	RNA polymerase activity
K3X48_RS01320	COG0203	ribosomal protein L17
K3X48_RS01330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K3X48_RS01345	COG0564	pseudouridine synthase activity
K3X48_RS01350	COG0546	phosphoglycolate phosphatase activity
K3X48_RS01360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3X48_RS01365	COG4597	amino acid ABC transporter
K3X48_RS01370	COG0765	amino acid transport
K3X48_RS01375	COG1126	abc transporter atp-binding protein
K3X48_RS01400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K3X48_RS01405	COG1028	Short-chain dehydrogenase reductase Sdr
K3X48_RS01410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K3X48_RS01420	COG0706	membrane insertase activity
K3X48_RS01425	COG5001	Diguanylate cyclase
K3X48_RS01430	COG0037	tRNA processing
K3X48_RS01445	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K3X48_RS01450	COG0594	ribonuclease P activity
K3X48_RS01455	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K3X48_RS01460	COG3734	2-keto-3-deoxy-galactonokinase
K3X48_RS01485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K3X48_RS01490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K3X48_RS01495	COG2885	chlorophyll binding
K3X48_RS01495	COG3047	cAMP biosynthetic process
K3X48_RS01515	COG1739	Uncharacterized protein family UPF0029
K3X48_RS01530	COG1435	thymidine kinase activity
K3X48_RS01535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K3X48_RS01540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3X48_RS01560	COG1136	(ABC) transporter
K3X48_RS01565	COG0438	transferase activity, transferring glycosyl groups
K3X48_RS01580	COG0187	DNA topoisomerase II activity
K3X48_RS01585	COG4335	DNA alkylation repair
K3X48_RS01590	COG0101	tRNA pseudouridine synthase activity
K3X48_RS01595	COG3106	COG3106 Predicted ATPase
K3X48_RS01605	COG3768	UPF0283 membrane protein
K3X48_RS01630	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K3X48_RS01640	COG1131	(ABC) transporter
K3X48_RS01645	COG0842	Transport permease protein
K3X48_RS01650	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X48_RS01650	COG0616	signal peptide processing
K3X48_RS01670	COG0322	excinuclease ABC activity
K3X48_RS01675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K3X48_RS01685	COG0314	molybdopterin synthase activity
K3X48_RS01695	COG1183	phosphatidylcholine synthase activity
K3X48_RS01710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K3X48_RS01720	COG2391	methyltransferase activity
K3X48_RS01730	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3X48_RS01735	COG2264	protein methyltransferase activity
K3X48_RS01760	COG2814	Major facilitator Superfamily
K3X48_RS01770	COG1045	serine acetyltransferase
K3X48_RS01775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3X48_RS01785	COG1570	exodeoxyribonuclease VII activity
K3X48_RS01795	COG0590	tRNA wobble adenosine to inosine editing
K3X48_RS01815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K3X48_RS01820	COG0154	amidase activity
K3X48_RS01830	COG3023	N-Acetylmuramoyl-L-alanine amidase
K3X48_RS01840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K3X48_RS01855	COG0670	Belongs to the BI1 family
K3X48_RS01865	COG0583	DNA-binding transcription factor activity
K3X48_RS01870	COG1028	Short-chain dehydrogenase reductase Sdr
K3X48_RS01870	COG3321	synthase
K3X48_RS01870	COG0604	alcohol dehydrogenase
K3X48_RS01880	COG0483	inositol monophosphate 1-phosphatase activity
K3X48_RS01890	COG0402	S-adenosylhomocysteine deaminase activity
K3X48_RS01895	COG2239	Acts as a magnesium transporter
K3X48_RS01900	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K3X48_RS01905	COG0471	metal ion transport
K3X48_RS01905	COG3273	potassium ion transport
K3X48_RS01910	COG1280	lysine exporter protein (LysE YggA)
K3X48_RS01930	COG0217	transcriptional regulatory protein
K3X48_RS01935	COG0778	Nitroreductase
K3X48_RS01950	COG0747	negative chemotaxis
K3X48_RS01955	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K3X48_RS01960	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K3X48_RS01965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K3X48_RS02005	COG1012	belongs to the aldehyde dehydrogenase family
K3X48_RS02020	COG0601	transmembrane transport
K3X48_RS02025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X48_RS02030	COG0444	Belongs to the ABC transporter superfamily
K3X48_RS02035	COG4608	Belongs to the ABC transporter superfamily
K3X48_RS02045	COG1042	CoA-binding domain protein
K3X48_RS02045	COG0045	succinate-CoA ligase (ADP-forming) activity
K3X48_RS02045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K3X48_RS02050	COG0123	including yeast histone deacetylase and acetoin utilization protein
K3X48_RS02065	COG0667	Aldo Keto reductase
K3X48_RS02075	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K3X48_RS02085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3X48_RS02090	COG1079	Belongs to the binding-protein-dependent transport system permease family
K3X48_RS02095	COG4603	Belongs to the binding-protein-dependent transport system permease family
K3X48_RS02100	COG3845	ABC transporter
K3X48_RS02110	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X48_RS02130	COG2900	Belongs to the SlyX family
K3X48_RS02135	COG0124	histidyl-tRNA synthetase
K3X48_RS02140	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K3X48_RS02145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K3X48_RS02150	COG0180	Tryptophanyl-tRNA synthetase
K3X48_RS02165	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K3X48_RS02175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K3X48_RS02180	COG0792	nuclease activity
K3X48_RS02185	COG0189	ligase activity
K3X48_RS02195	COG0606	chelatase, subunit chli
K3X48_RS02220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K3X48_RS02225	COG0756	dUTP diphosphatase activity
K3X48_RS02230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K3X48_RS02245	COG0765	amino acid transport
K3X48_RS02250	COG0339	signal peptide processing
K3X48_RS02255	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K3X48_RS02320	COG3118	belongs to the thioredoxin family
K3X48_RS02325	COG0509	glycine decarboxylation via glycine cleavage system
K3X48_RS02335	COG0534	Mate efflux family protein
K3X48_RS02345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3X48_RS02375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3X48_RS02395	COG0768	penicillin binding
K3X48_RS02400	COG0772	Belongs to the SEDS family
K3X48_RS02440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K3X48_RS02455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K3X48_RS02460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K3X48_RS02465	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K3X48_RS02470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K3X48_RS02475	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K3X48_RS02505	COG0596	Alpha beta hydrolase
K3X48_RS02505	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X48_RS02515	COG2983	Belongs to the UPF0260 family
K3X48_RS02525	COG0196	riboflavin kinase activity
K3X48_RS02530	COG2030	dehydratase
K3X48_RS02545	COG1227	inorganic diphosphatase activity
K3X48_RS02555	COG1858	cytochrome C peroxidase
K3X48_RS02565	COG0459	protein refolding
K3X48_RS02580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3X48_RS02585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3X48_RS02610	COG2010	Cytochrome c
K3X48_RS02615	COG0348	domain, Protein
K3X48_RS02635	COG2197	response regulator
K3X48_RS02645	COG4181	ATPase activity
K3X48_RS02650	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K3X48_RS02685	COG2030	dehydratase
K3X48_RS02695	COG2301	Belongs to the HpcH HpaI aldolase family
K3X48_RS02710	COG0039	L-malate dehydrogenase activity
K3X48_RS02720	COG0045	succinate-CoA ligase (ADP-forming) activity
K3X48_RS02730	COG0567	Dehydrogenase, E1 component
K3X48_RS02735	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X48_RS02775	COG0642	Histidine kinase
K3X48_RS02805	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K3X48_RS02825	COG0356	it plays a direct role in the translocation of protons across the membrane
K3X48_RS02830	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K3X48_RS02835	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K3X48_RS02840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K3X48_RS02850	COG2186	Transcriptional regulator
K3X48_RS02855	COG2885	chlorophyll binding
K3X48_RS02865	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K3X48_RS02870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3X48_RS02875	COG1765	OsmC-like protein
K3X48_RS02900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3X48_RS02900	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3X48_RS02920	COG3622	Belongs to the hyi family
K3X48_RS02930	COG0714	Associated with various cellular activities
K3X48_RS02950	COG0277	FAD linked oxidase domain protein
K3X48_RS02955	COG0277	FAD linked oxidase domain protein
K3X48_RS02960	COG0247	lactate metabolic process
K3X48_RS02970	COG0071	Belongs to the small heat shock protein (HSP20) family
K3X48_RS02980	COG3191	aminopeptidase activity
K3X48_RS02990	COG3214	Protein conserved in bacteria
K3X48_RS03000	COG1012	belongs to the aldehyde dehydrogenase family
K3X48_RS03010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X48_RS03020	COG2151	metal-sulfur cluster biosynthetic enzyme
K3X48_RS03020	COG0489	protein tyrosine kinase activity
K3X48_RS03040	COG0254	rRNA binding
K3X48_RS03045	COG0335	large ribosomal subunit rRNA binding
K3X48_RS03050	COG0336	Belongs to the RNA methyltransferase TrmD family
K3X48_RS03060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K3X48_RS03065	COG0778	Nitroreductase
K3X48_RS03070	COG0228	four-way junction DNA binding
K3X48_RS03090	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K3X48_RS03110	COG1054	Belongs to the UPF0176 family
K3X48_RS03120	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K3X48_RS03140	COG1280	lysine exporter protein (LysE YggA)
K3X48_RS03150	COG1309	transcriptional regulator
K3X48_RS03155	COG3119	arylsulfatase activity
K3X48_RS03160	COG1012	belongs to the aldehyde dehydrogenase family
K3X48_RS03175	COG1396	sequence-specific DNA binding
K3X48_RS03175	COG3800	Transcriptional regulator
K3X48_RS03180	COG2814	Major facilitator Superfamily
K3X48_RS03185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K3X48_RS03210	COG4770	biotin carboxylase activity
K3X48_RS03220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X48_RS03220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X48_RS03230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X48_RS03235	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K3X48_RS03255	COG0248	Ppx GppA phosphatase
K3X48_RS03260	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K3X48_RS03270	COG0628	permease
K3X48_RS03285	COG0442	prolyl-tRNA aminoacylation
K3X48_RS03295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K3X48_RS03300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K3X48_RS03320	COG0529	Catalyzes the synthesis of activated sulfate
K3X48_RS03320	COG2046	Belongs to the sulfate adenylyltransferase family
K3X48_RS03330	COG0492	ferredoxin-NADP+ reductase activity
K3X48_RS03335	COG1522	sequence-specific DNA binding
K3X48_RS03345	COG1496	oxidoreductase activity
K3X48_RS03355	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K3X48_RS03370	COG1573	uracil-dna glycosylase
K3X48_RS03385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X48_RS03400	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K3X48_RS03410	COG0463	Glycosyl transferase, family 2
K3X48_RS03455	COG0174	glutamine synthetase
K3X48_RS03480	COG0022	dehydrogenase e1 component
K3X48_RS03485	COG0583	DNA-binding transcription factor activity
K3X48_RS03495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X48_RS03500	COG1012	belongs to the aldehyde dehydrogenase family
K3X48_RS03505	COG0583	DNA-binding transcription factor activity
K3X48_RS03515	COG0556	nucleotide-excision repair
K3X48_RS03525	COG2267	carboxylic ester hydrolase activity
K3X48_RS03535	COG3739	integral membrane protein
K3X48_RS03545	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K3X48_RS03560	COG2204	response regulator
K3X48_RS03570	COG0280	phosphate acetyltransferase
K3X48_RS03570	COG0281	malic enzyme
K3X48_RS03580	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K3X48_RS03585	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K3X48_RS03590	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K3X48_RS03605	COG0318	PFAM AMP-dependent synthetase and ligase
K3X48_RS03620	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X48_RS03620	COG1024	Enoyl-CoA hydratase
K3X48_RS03625	COG0183	Belongs to the thiolase family
K3X48_RS03630	COG0625	glutathione transferase activity
K3X48_RS03640	COG1960	acyl-CoA dehydrogenase activity
K3X48_RS03675	COG0534	Mate efflux family protein
K3X48_RS03680	COG1393	Belongs to the ArsC family
K3X48_RS03695	COG3257	ureidoglycine aminohydrolase activity
K3X48_RS03705	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
K3X48_RS03715	COG0737	Belongs to the 5'-nucleotidase family
K3X48_RS03725	COG2135	peptidase activity
K3X48_RS03730	COG0154	amidase activity
K3X48_RS03735	COG0318	PFAM AMP-dependent synthetase and ligase
K3X48_RS03740	COG0174	glutamine synthetase
K3X48_RS03745	COG1177	transmembrane transport
K3X48_RS03750	COG1176	ABC-type spermidine putrescine transport system, permease component I
K3X48_RS03755	COG3842	ATPase activity
K3X48_RS03785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K3X48_RS03790	COG0602	queuosine metabolic process
K3X48_RS03795	COG0720	synthase
K3X48_RS03800	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K3X48_RS03810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K3X48_RS03825	COG1492	cobalamin metabolic process
K3X48_RS03835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K3X48_RS03845	COG0354	folic acid binding
K3X48_RS03850	COG1132	(ABC) transporter
K3X48_RS03860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K3X48_RS03865	COG0525	valine-tRNA ligase activity
K3X48_RS03870	COG0033	Phosphoglucomutase
K3X48_RS03880	COG0019	diaminopimelate decarboxylase activity
K3X48_RS03895	COG0583	DNA-binding transcription factor activity
K3X48_RS03900	COG0483	inositol monophosphate 1-phosphatase activity
K3X48_RS03925	COG1136	(ABC) transporter
K3X48_RS03945	COG3842	ATPase activity
K3X48_RS03955	COG1176	ABC-type spermidine putrescine transport system, permease component I
K3X48_RS03960	COG1177	transmembrane transport
K3X48_RS03965	COG0740	serine-type endopeptidase activity
K3X48_RS03970	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K3X48_RS03990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K3X48_RS03995	COG0439	Biotin carboxylase
K3X48_RS04010	COG1309	transcriptional regulator
K3X48_RS04025	COG0318	PFAM AMP-dependent synthetase and ligase
K3X48_RS04035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X48_RS04040	COG0410	ABC transporter
K3X48_RS04065	COG1396	sequence-specific DNA binding
K3X48_RS04065	COG3800	Transcriptional regulator
K3X48_RS04070	COG0745	RESPONSE REGULATOR receiver
K3X48_RS04080	COG2205	protein histidine kinase activity
K3X48_RS04090	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K3X48_RS04105	COG3750	Belongs to the UPF0335 family
K3X48_RS04110	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K3X48_RS04115	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K3X48_RS04175	COG1459	type II secretion system
K3X48_RS04180	COG1450	Type ii and iii secretion system protein
K3X48_RS04195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K3X48_RS04220	COG0840	transmembrane signaling receptor activity
K3X48_RS04240	COG0028	Belongs to the TPP enzyme family
K3X48_RS04245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3X48_RS04255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X48_RS04260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3X48_RS04260	COG0519	Catalyzes the synthesis of GMP from XMP
K3X48_RS04290	COG0488	(ABC) transporter
K3X48_RS04305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K3X48_RS04315	COG0625	glutathione transferase activity
K3X48_RS04330	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K3X48_RS04345	COG2326	polyphosphate kinase activity
K3X48_RS04350	COG2951	lytic endotransglycosylase activity
K3X48_RS04355	COG0534	Mate efflux family protein
K3X48_RS04405	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K3X48_RS04415	COG1278	Cold shock
K3X48_RS04420	COG1393	Belongs to the ArsC family
K3X48_RS04440	COG3220	belongs to the UPF0276 family
K3X48_RS04450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K3X48_RS04460	COG2267	carboxylic ester hydrolase activity
K3X48_RS04485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K3X48_RS04490	COG0303	'Molybdopterin
K3X48_RS04495	COG0315	cyclic pyranopterin monophosphate synthase activity
K3X48_RS04505	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K3X48_RS04510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K3X48_RS04535	COG0148	phosphopyruvate hydratase activity
K3X48_RS04550	COG0384	phenazine biosynthesis protein PhzF
K3X48_RS04565	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K3X48_RS04570	COG0456	acetyltransferase
K3X48_RS04575	COG1957	nucleoside hydrolase
K3X48_RS04585	COG2081	HI0933 family
K3X48_RS04590	COG0316	Belongs to the HesB IscA family
K3X48_RS04595	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K3X48_RS04600	COG0018	arginyl-trna synthetase
K3X48_RS04610	COG1472	Belongs to the glycosyl hydrolase 3 family
K3X48_RS04615	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K3X48_RS04620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K3X48_RS04630	COG0717	Belongs to the dCTP deaminase family
K3X48_RS04645	COG0776	regulation of translation
K3X48_RS04650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K3X48_RS04655	COG0416	fatty acid biosynthetic process
K3X48_RS04660	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K3X48_RS04675	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3X48_RS04685	COG0488	(ABC) transporter
K3X48_RS04695	COG1272	protein, Hemolysin III
K3X48_RS04700	COG0076	glutamate decarboxylase activity
K3X48_RS04705	COG0149	triose-phosphate isomerase activity
K3X48_RS04710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K3X48_RS04715	COG0316	Belongs to the HesB IscA family
K3X48_RS04730	COG2151	metal-sulfur cluster biosynthetic enzyme
K3X48_RS04735	COG0343	queuine tRNA-ribosyltransferase activity
K3X48_RS04745	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K3X48_RS04770	COG0406	alpha-ribazole phosphatase activity
K3X48_RS04795	COG0156	8-amino-7-oxononanoate synthase activity
K3X48_RS04805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K3X48_RS04815	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K3X48_RS04825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X48_RS04835	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X48_RS04835	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X48_RS04880	COG2962	Rard protein
K3X48_RS04895	COG5265	(ABC) transporter
K3X48_RS04900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3X48_RS04925	COG1160	GTP binding
K3X48_RS04945	COG4221	oxidoreductase activity
K3X48_RS04960	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K3X48_RS04985	COG1127	ABC transporter
K3X48_RS04990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K3X48_RS05025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K3X48_RS05045	COG0544	peptidyl-prolyl cis-trans isomerase activity
K3X48_RS05055	COG0359	binds to the 23S rRNA
K3X48_RS05060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K3X48_RS05065	COG0360	Binds together with S18 to 16S ribosomal RNA
K3X48_RS05075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K3X48_RS05085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3X48_RS05090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K3X48_RS05095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K3X48_RS05110	COG4695	Portal protein
K3X48_RS05200	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X48_RS05205	COG0022	dehydrogenase e1 component
K3X48_RS05205	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X48_RS05210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K3X48_RS05215	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K3X48_RS05220	COG3588	fructose-bisphosphate aldolase
K3X48_RS05250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K3X48_RS05260	COG0436	Aminotransferase
K3X48_RS05265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K3X48_RS05270	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K3X48_RS05280	COG0006	proline dipeptidase activity
K3X48_RS05285	COG1473	amidohydrolase
K3X48_RS05320	COG0826	peptidase U32
K3X48_RS05325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K3X48_RS05330	COG0308	aminopeptidase N
K3X48_RS05345	COG2155	Conserved Protein
K3X48_RS05350	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K3X48_RS05380	COG2010	Cytochrome c
K3X48_RS05380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X48_RS05395	COG0436	Aminotransferase
K3X48_RS05410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K3X48_RS05430	COG1741	Belongs to the pirin family
K3X48_RS05445	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K3X48_RS05460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K3X48_RS05465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K3X48_RS05480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K3X48_RS05485	COG1181	Belongs to the D-alanine--D-alanine ligase family
K3X48_RS05490	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K3X48_RS05495	COG0849	cell division
K3X48_RS05500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K3X48_RS05505	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K3X48_RS05510	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X48_RS05520	COG0277	FAD linked oxidase domain protein
K3X48_RS05525	COG0038	chloride channel
K3X48_RS05530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K3X48_RS05535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K3X48_RS05545	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K3X48_RS05560	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K3X48_RS05575	COG2095	MarC family integral membrane protein
K3X48_RS05580	COG0488	(ABC) transporter
K3X48_RS05585	COG0105	UTP biosynthetic process
K3X48_RS05615	COG2205	protein histidine kinase activity
K3X48_RS05615	COG0784	Response regulator, receiver
K3X48_RS05615	COG2198	Histidine kinase
K3X48_RS05630	COG0587	DNA-directed DNA polymerase activity
K3X48_RS05710	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K3X48_RS05720	COG0730	response to heat
K3X48_RS05770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K3X48_RS05785	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K3X48_RS05795	COG1522	sequence-specific DNA binding
K3X48_RS05825	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3X48_RS05830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3X48_RS05845	COG0433	COG0433 Predicted ATPase
K3X48_RS05850	COG4536	flavin adenine dinucleotide binding
K3X48_RS05860	COG0004	ammonium transporteR
K3X48_RS06055	COG0456	acetyltransferase
K3X48_RS06065	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K3X48_RS06070	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K3X48_RS06075	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K3X48_RS06085	COG2166	iron-sulfur cluster assembly
K3X48_RS06100	COG5012	cobalamin binding
K3X48_RS06110	COG0646	methionine synthase
K3X48_RS06110	COG1410	methionine synthase
K3X48_RS06125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K3X48_RS06130	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K3X48_RS06135	COG0047	phosphoribosylformylglycinamidine synthase activity
K3X48_RS06145	COG2204	response regulator
K3X48_RS06150	COG0457	Tetratricopeptide repeat
K3X48_RS06155	COG3743	rRNA binding
K3X48_RS06155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K3X48_RS06160	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K3X48_RS06180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K3X48_RS06185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K3X48_RS06190	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K3X48_RS06235	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K3X48_RS06245	COG2321	neutral zinc metallopeptidase
K3X48_RS06270	COG0626	cystathionine gamma-synthase activity
K3X48_RS06330	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K3X48_RS06340	COG1561	YicC-like family, N-terminal region
K3X48_RS06345	COG0194	GDP metabolic process
K3X48_RS06360	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K3X48_RS06370	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K3X48_RS06375	COG2867	negative regulation of translational initiation
K3X48_RS06380	COG4974	Belongs to the 'phage' integrase family
K3X48_RS06395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K3X48_RS06400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K3X48_RS06405	COG1058	Belongs to the CinA family
K3X48_RS06405	COG1546	Belongs to the CinA family
K3X48_RS06415	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K3X48_RS06415	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K3X48_RS06420	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K3X48_RS06425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K3X48_RS06430	COG3852	Histidine kinase
K3X48_RS06435	COG2204	response regulator
K3X48_RS06440	COG5000	phosphorelay sensor kinase activity
K3X48_RS06445	COG2204	response regulator
K3X48_RS06450	COG0569	domain protein
K3X48_RS06455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K3X48_RS06465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K3X48_RS06475	COG2084	Dehydrogenase
K3X48_RS06495	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K3X48_RS06500	COG2814	Major facilitator Superfamily
K3X48_RS06510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K3X48_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
K3X48_RS06540	COG2313	pseudouridylate synthase activity
K3X48_RS06545	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K3X48_RS06545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K3X48_RS06550	COG0052	Belongs to the universal ribosomal protein uS2 family
K3X48_RS06555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K3X48_RS06565	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K3X48_RS06580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X48_RS06585	COG4311	Sarcosine oxidase, delta subunit
K3X48_RS06590	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X48_RS06590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X48_RS06600	COG4977	sequence-specific DNA binding
K3X48_RS06610	COG1012	belongs to the aldehyde dehydrogenase family
K3X48_RS06630	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K3X48_RS06635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K3X48_RS06645	COG0824	Thioesterase
K3X48_RS06645	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X48_RS06650	COG1028	Short-chain dehydrogenase reductase Sdr
K3X48_RS06655	COG3246	L-lysine catabolic process to acetate
K3X48_RS06660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X48_RS06670	COG3831	ATPase activity
K3X48_RS06675	COG0714	Associated with various cellular activities
K3X48_RS06680	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K3X48_RS06685	COG3552	Protein containing von Willebrand factor type A (VWA) domain
K3X48_RS06695	COG0745	RESPONSE REGULATOR receiver
K3X48_RS06705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K3X48_RS06715	COG0573	inorganic phosphate transmembrane transporter activity
K3X48_RS06730	COG5002	protein histidine kinase activity
K3X48_RS06750	COG5598	trimethylamine methyltransferase
K3X48_RS06755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3X48_RS06755	COG0519	Catalyzes the synthesis of GMP from XMP
K3X48_RS06780	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K3X48_RS06785	COG2326	polyphosphate kinase activity
K3X48_RS06790	COG1309	transcriptional regulator
K3X48_RS06795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K3X48_RS06810	COG0719	Fe-S assembly protein
K3X48_RS06815	COG0396	ATPase activity
K3X48_RS06835	COG0719	Fe-S assembly protein
K3X48_RS06840	COG1104	cysteine desulfurase activity
K3X48_RS06850	COG1959	2 iron, 2 sulfur cluster binding
K3X48_RS06855	COG2945	thiolester hydrolase activity
K3X48_RS06875	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K3X48_RS06880	COG1612	heme a metabolic process
K3X48_RS06885	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K3X48_RS06895	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K3X48_RS06900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3X48_RS06905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K3X48_RS06915	COG0840	transmembrane signaling receptor activity
K3X48_RS06920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K3X48_RS06925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K3X48_RS06930	COG0745	RESPONSE REGULATOR receiver
K3X48_RS06940	COG0482	sulfurtransferase activity
K3X48_RS06950	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3X48_RS06960	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3X48_RS06965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K3X48_RS06975	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X48_RS06985	COG0750	zinc metalloprotease
K3X48_RS06990	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K3X48_RS07000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K3X48_RS07005	COG0233	cytoplasmic translational termination
K3X48_RS07010	COG0528	UMP kinase activity
K3X48_RS07020	COG2207	Transcriptional regulator
K3X48_RS07025	COG0741	lytic transglycosylase activity
K3X48_RS07030	COG0629	single-stranded DNA binding
K3X48_RS07045	COG1686	Belongs to the peptidase S11 family
K3X48_RS07050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K3X48_RS07060	COG0084	hydrolase, TatD family'
K3X48_RS07085	COG3396	Phenylacetate-CoA oxygenase
K3X48_RS07090	COG3460	Phenylacetate-CoA oxygenase
K3X48_RS07095	COG3396	Phenylacetate-CoA oxygenase
K3X48_RS07100	COG2151	metal-sulfur cluster biosynthetic enzyme
K3X48_RS07105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K3X48_RS07115	COG1012	belongs to the aldehyde dehydrogenase family
K3X48_RS07115	COG2030	dehydratase
K3X48_RS07140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K3X48_RS07155	COG1024	Enoyl-CoA hydratase
K3X48_RS07160	COG0121	glutamine amidotransferase
K3X48_RS07170	COG1217	gtp-binding protein TYPA
K3X48_RS07185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K3X48_RS07190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K3X48_RS07200	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K3X48_RS07200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K3X48_RS07205	COG0517	IMP dehydrogenase activity
K3X48_RS07205	COG0516	GMP reductase activity
K3X48_RS07230	COG0542	response to heat
K3X48_RS07250	COG2814	Major facilitator Superfamily
K3X48_RS07275	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K3X48_RS07285	COG0129	dihydroxy-acid dehydratase activity
K3X48_RS07290	COG0800	Aldolase
K3X48_RS07300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3X48_RS07305	COG0215	cysteine-tRNA ligase activity
K3X48_RS07390	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K3X48_RS07395	COG0737	Belongs to the 5'-nucleotidase family
K3X48_RS07400	COG3258	Cytochrome c
K3X48_RS07420	COG0785	Cytochrome C biogenesis protein
K3X48_RS07435	COG2391	methyltransferase activity
K3X48_RS07460	COG2873	o-acetylhomoserine
K3X48_RS07465	COG2968	Membrane
K3X48_RS07475	COG1522	sequence-specific DNA binding
K3X48_RS07480	COG0840	transmembrane signaling receptor activity
K3X48_RS07485	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K3X48_RS07490	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K3X48_RS07495	COG1329	Transcriptional regulator
K3X48_RS07500	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K3X48_RS07505	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K3X48_RS07540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K3X48_RS07570	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K3X48_RS07580	COG1797	cobyrinic acid a,c-diamide synthase activity
K3X48_RS07585	COG2814	Major facilitator Superfamily
K3X48_RS07595	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K3X48_RS07615	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K3X48_RS07620	COG0028	Belongs to the TPP enzyme family
K3X48_RS07625	COG0440	acetolactate synthase activity
K3X48_RS07635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K3X48_RS07655	COG0259	pyridoxamine-phosphate oxidase activity
K3X48_RS07660	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K3X48_RS07665	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K3X48_RS07675	COG2890	protein-(glutamine-N5) methyltransferase activity
K3X48_RS07680	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K3X48_RS07695	COG0010	Belongs to the arginase family
K3X48_RS07700	COG1473	amidohydrolase
K3X48_RS07705	COG3956	TIGRFAM MazG family protein
K3X48_RS07710	COG1840	ABC-type Fe3 transport system, periplasmic component
K3X48_RS07720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K3X48_RS07730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K3X48_RS07745	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K3X48_RS07755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K3X48_RS07760	COG2833	Protein of unknown function (DUF455)
K3X48_RS07765	COG0739	heme binding
K3X48_RS07780	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K3X48_RS07785	COG3842	ATPase activity
K3X48_RS07790	COG0395	ABC-type sugar transport system, permease component
K3X48_RS07795	COG1175	transmembrane transport
K3X48_RS07800	COG1653	transport
K3X48_RS07810	COG0745	RESPONSE REGULATOR receiver
K3X48_RS07820	COG0835	chemotaxis
K3X48_RS07825	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K3X48_RS07830	COG0745	RESPONSE REGULATOR receiver
K3X48_RS07845	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K3X48_RS07850	COG2201	protein-glutamate methylesterase activity
K3X48_RS07855	COG0840	transmembrane signaling receptor activity
K3X48_RS07865	COG2205	protein histidine kinase activity
K3X48_RS07865	COG0784	Response regulator, receiver
K3X48_RS07865	COG5002	protein histidine kinase activity
K3X48_RS07880	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K3X48_RS07935	COG4964	Belongs to the GSP D family
K3X48_RS08000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K3X48_RS08005	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3X48_RS08005	COG3264	Mechanosensitive ion channel
K3X48_RS08015	COG0494	nUDIX hydrolase
K3X48_RS08025	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K3X48_RS08030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K3X48_RS08035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K3X48_RS08050	COG0604	alcohol dehydrogenase
K3X48_RS08055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X48_RS08075	COG3738	Protein conserved in bacteria
K3X48_RS08090	COG0114	fumarate hydratase activity
K3X48_RS08120	COG0785	Cytochrome C biogenesis protein
K3X48_RS08125	COG0425	Belongs to the sulfur carrier protein TusA family
K3X48_RS08130	COG1530	ribonuclease E activity
K3X48_RS08135	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K3X48_RS08140	COG1164	Oligoendopeptidase f
K3X48_RS08155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K3X48_RS08185	COG0564	pseudouridine synthase activity
K3X48_RS08220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K3X48_RS08225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K3X48_RS08230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K3X48_RS08230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K3X48_RS08265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K3X48_RS08265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K3X48_RS08275	COG0432	Pfam Uncharacterised protein family UPF0047
K3X48_RS08295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K3X48_RS08300	COG0358	DNA primase activity
K3X48_RS08305	COG1309	transcriptional regulator
K3X48_RS08325	COG1335	isochorismatase
K3X48_RS08330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K3X48_RS08340	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K3X48_RS08350	COG1984	allophanate hydrolase subunit 2
K3X48_RS08420	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X48_RS08420	COG0824	Thioesterase
K3X48_RS08430	COG3246	L-lysine catabolic process to acetate
K3X48_RS08440	COG0667	Aldo Keto reductase
K3X48_RS08445	COG1028	Short-chain dehydrogenase reductase Sdr
K3X48_RS08470	COG0513	Belongs to the DEAD box helicase family
K3X48_RS08480	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K3X48_RS08490	COG1007	ATP synthesis coupled electron transport
K3X48_RS08505	COG0713	ATP synthesis coupled electron transport
K3X48_RS08520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3X48_RS08525	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K3X48_RS08565	COG0649	NAD binding
K3X48_RS08575	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3X48_RS08580	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3X48_RS08590	COG1024	Enoyl-CoA hydratase
K3X48_RS08605	COG4770	biotin carboxylase activity
K3X48_RS08610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K3X48_RS08620	COG1960	acyl-CoA dehydrogenase activity
K3X48_RS08630	COG0546	phosphoglycolate phosphatase activity
K3X48_RS08635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K3X48_RS08655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X48_RS08665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K3X48_RS08670	COG1473	amidohydrolase
K3X48_RS08675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X48_RS08695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K3X48_RS08700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K3X48_RS08705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K3X48_RS08720	COG0275	rRNA processing
K3X48_RS08725	COG2001	Belongs to the MraZ family
K3X48_RS08730	COG0489	protein tyrosine kinase activity
K3X48_RS08740	COG0210	DNA helicase
K3X48_RS08745	COG1754	DNA topoisomerase type I activity
K3X48_RS08745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K3X48_RS08745	COG1754	DNA topoisomerase type I activity
K3X48_RS08745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K3X48_RS08750	COG3273	potassium ion transport
K3X48_RS08750	COG0471	metal ion transport
K3X48_RS08785	COG0277	FAD linked oxidase domain protein
K3X48_RS08790	COG1028	Short-chain dehydrogenase reductase Sdr
K3X48_RS08825	COG4964	Belongs to the GSP D family
K3X48_RS08880	COG1201	RNA secondary structure unwinding
K3X48_RS08895	COG1024	Enoyl-CoA hydratase
K3X48_RS08905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K3X48_RS08910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K3X48_RS08915	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K3X48_RS08920	COG3239	Fatty acid desaturase
K3X48_RS08930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K3X48_RS08935	COG0037	tRNA processing
K3X48_RS08945	COG2885	chlorophyll binding
K3X48_RS08970	COG0824	Thioesterase
K3X48_RS08985	COG2255	four-way junction helicase activity
K3X48_RS08990	COG0632	four-way junction helicase activity
K3X48_RS09000	COG1053	succinate dehydrogenase
K3X48_RS09015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K3X48_RS09030	COG0330	HflC and HflK could
K3X48_RS09035	COG0330	HflC and HflK could
K3X48_RS09045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K3X48_RS09050	COG2832	Protein of unknown function (DUF454)
K3X48_RS09055	COG1760	l-serine dehydratase
K3X48_RS09080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K3X48_RS09090	COG0504	CTP synthase activity
K3X48_RS09120	COG4215	(ABC) transporter
K3X48_RS09130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3X48_RS09130	COG0519	Catalyzes the synthesis of GMP from XMP
K3X48_RS09135	COG0174	glutamine synthetase
K3X48_RS09140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K3X48_RS09145	COG0583	DNA-binding transcription factor activity
K3X48_RS09150	COG0658	competence protein
K3X48_RS09150	COG2333	competence protein COMEC
K3X48_RS09155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3X48_RS09165	COG1024	Enoyl-CoA hydratase
K3X48_RS09170	COG3088	subunit of a heme lyase
K3X48_RS09175	COG1138	Cytochrome C-type biogenesis protein
K3X48_RS09205	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K3X48_RS09210	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K3X48_RS09230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K3X48_RS09235	COG1357	PFAM Pentapeptide repeats (8 copies)
K3X48_RS09245	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K3X48_RS09260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K3X48_RS09265	COG0697	spore germination
K3X48_RS09270	COG2354	Protein conserved in bacteria
K3X48_RS09295	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K3X48_RS09325	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
K3X48_RS09330	COG1960	acyl-CoA dehydrogenase activity
K3X48_RS09335	COG1024	Enoyl-CoA hydratase
K3X48_RS09355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X48_RS09360	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3X48_RS09365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3X48_RS09375	COG4191	Histidine kinase
K3X48_RS09380	COG1522	sequence-specific DNA binding
K3X48_RS09390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K3X48_RS09395	COG0175	sulfate reduction
K3X48_RS09410	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K3X48_RS09425	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K3X48_RS09425	COG3608	succinylglutamate desuccinylase aspartoacylase
K3X48_RS09475	COG0418	dihydroorotase activity
K3X48_RS09480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K3X48_RS09485	COG0305	Participates in initiation and elongation during chromosome replication
K3X48_RS09505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K3X48_RS09515	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K3X48_RS09530	COG0300	oxidoreductase activity
K3X48_RS09535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3X48_RS09545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K3X48_RS09550	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K3X48_RS09555	COG4133	protoheme IX ABC transporter activity
K3X48_RS09560	COG3737	Protein of unknown function (DUF498/DUF598)
K3X48_RS09570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K3X48_RS09575	COG1862	Preprotein translocase
K3X48_RS09585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K3X48_RS09595	COG0805	protein transport
K3X48_RS09605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K3X48_RS09615	COG3842	ATPase activity
K3X48_RS09630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3X48_RS09645	COG1028	Short-chain dehydrogenase reductase Sdr
K3X48_RS09675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K3X48_RS09690	COG0659	secondary active sulfate transmembrane transporter activity
K3X48_RS09695	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K3X48_RS09700	COG2311	Membrane
K3X48_RS09705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K3X48_RS09720	COG0612	Peptidase, M16
K3X48_RS09740	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K3X48_RS09750	COG0109	protoheme IX farnesyltransferase activity
K3X48_RS09760	COG0312	modulator of DNA gyrase
K3X48_RS09775	COG0758	DNA mediated transformation
K3X48_RS09780	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K3X48_RS09810	COG0131	Imidazoleglycerol-phosphate dehydratase
K3X48_RS09820	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K3X48_RS09830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K3X48_RS09840	COG0107	imidazoleglycerol-phosphate synthase activity
K3X48_RS09845	COG0140	phosphoribosyl-ATP diphosphatase activity
K3X48_RS09860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K3X48_RS09870	COG1618	nucleotide phosphatase activity, acting on free nucleotides
K3X48_RS09870	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3X48_RS09875	COG3005	denitrification pathway
K3X48_RS09885	COG0348	domain, Protein
K3X48_RS09890	COG0437	4 iron, 4 sulfur cluster binding
K3X48_RS09895	COG0243	molybdopterin cofactor binding
K3X48_RS09905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K3X48_RS09905	COG2221	Nitrite and sulphite reductase 4Fe-4S
K3X48_RS09940	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K3X48_RS09945	COG1530	ribonuclease E activity
K3X48_RS09955	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K3X48_RS09980	COG5328	Belongs to the UPF0262 family
K3X48_RS09985	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K3X48_RS09995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K3X48_RS10015	COG3916	Acyl-homoserine-lactone synthase
K3X48_RS10025	COG0318	PFAM AMP-dependent synthetase and ligase
K3X48_RS10030	COG1132	(ABC) transporter
K3X48_RS10035	COG0116	Belongs to the methyltransferase superfamily
K3X48_RS10035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K3X48_RS10045	COG2188	Transcriptional regulator
K3X48_RS10055	COG2267	carboxylic ester hydrolase activity
K3X48_RS10065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K3X48_RS10070	COG1012	belongs to the aldehyde dehydrogenase family
K3X48_RS10090	COG0826	peptidase U32
K3X48_RS10100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K3X48_RS10140	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K3X48_RS10150	COG1805	sodium ion transport
K3X48_RS10155	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K3X48_RS10160	COG1477	protein flavinylation
K3X48_RS10185	COG0321	lipoyl(octanoyl) transferase activity
K3X48_RS10190	COG3474	cytochrome
K3X48_RS10210	COG0505	Belongs to the CarA family
K3X48_RS10220	COG1802	Transcriptional regulator
K3X48_RS10255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K3X48_RS10265	COG0697	spore germination
K3X48_RS10270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K3X48_RS10290	COG0574	Belongs to the PEP-utilizing enzyme family
K3X48_RS10290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K3X48_RS10295	COG0751	glycine-tRNA ligase activity
K3X48_RS10305	COG0752	glycyl-tRNA synthetase alpha subunit
K3X48_RS10320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K3X48_RS10330	COG1469	GTP cyclohydrolase I activity
K3X48_RS10340	COG2917	probably involved in intracellular septation
K3X48_RS10350	COG0552	protein localization to endoplasmic reticulum
K3X48_RS10380	COG3853	Toxic anion resistance protein (TelA)
K3X48_RS10405	COG1490	D-aminoacyl-tRNA deacylase activity
K3X48_RS10415	COG0287	Prephenate dehydrogenase
K3X48_RS10420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K3X48_RS10430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K3X48_RS10450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K3X48_RS10480	COG2197	response regulator
K3X48_RS10495	COG0444	Belongs to the ABC transporter superfamily
K3X48_RS10500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X48_RS10505	COG0601	transmembrane transport
K3X48_RS10550	COG0559	Belongs to the binding-protein-dependent transport system permease family
K3X48_RS10585	COG3273	potassium ion transport
K3X48_RS10585	COG0471	metal ion transport
K3X48_RS10595	COG1692	metallophosphoesterase
K3X48_RS10600	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K3X48_RS10605	COG1214	PFAM Peptidase M22, glycoprotease
K3X48_RS10615	COG1744	ABC transporter substrate-binding protein PnrA-like
K3X48_RS10620	COG3845	ABC transporter
K3X48_RS10625	COG4603	Belongs to the binding-protein-dependent transport system permease family
K3X48_RS10630	COG1079	Belongs to the binding-protein-dependent transport system permease family
K3X48_RS10650	COG1028	Short-chain dehydrogenase reductase Sdr
K3X48_RS10665	COG2197	response regulator
K3X48_RS10675	COG0604	alcohol dehydrogenase
K3X48_RS10680	COG2937	Belongs to the GPAT DAPAT family
K3X48_RS10685	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X48_RS10685	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X48_RS10695	COG0813	purine-nucleoside phosphorylase activity
K3X48_RS10705	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3X48_RS10705	COG1618	nucleotide phosphatase activity, acting on free nucleotides
K3X48_RS10720	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X48_RS10725	COG1012	belongs to the aldehyde dehydrogenase family
K3X48_RS10730	COG1960	acyl-CoA dehydrogenase activity
K3X48_RS10735	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3X48_RS10740	COG3800	Transcriptional regulator
K3X48_RS10740	COG1396	sequence-specific DNA binding
K3X48_RS10745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3X48_RS10765	COG0625	glutathione transferase activity
K3X48_RS10790	COG1129	ABC transporter
K3X48_RS10795	COG4214	carbohydrate transport
K3X48_RS10805	COG1609	Transcriptional regulator
K3X48_RS10810	COG0673	inositol 2-dehydrogenase activity
K3X48_RS10820	COG0673	inositol 2-dehydrogenase activity
K3X48_RS10825	COG3962	Belongs to the TPP enzyme family
K3X48_RS10830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3X48_RS10840	COG0191	fructose-bisphosphate aldolase activity
K3X48_RS10845	COG0673	inositol 2-dehydrogenase activity
K3X48_RS10870	COG2353	YceI-like domain
K3X48_RS10880	COG0012	GTP binding
K3X48_RS10890	COG0159	tryptophan synthase activity
K3X48_RS10905	COG0513	Belongs to the DEAD box helicase family
K3X48_RS10925	COG0193	aminoacyl-tRNA hydrolase activity
K3X48_RS10940	COG0133	tryptophan synthase activity
K3X48_RS10945	COG0135	phosphoribosylanthranilate isomerase activity
K3X48_RS10955	COG0776	regulation of translation
K3X48_RS10960	COG0539	negative regulation of cytoplasmic translation
K3X48_RS10970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K3X48_RS10990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K3X48_RS10995	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K3X48_RS11000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K3X48_RS11005	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K3X48_RS11010	COG1253	flavin adenine dinucleotide binding
K3X48_RS11015	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K3X48_RS11020	COG1702	phosphate starvation-inducible protein PhoH
K3X48_RS11035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3X48_RS11045	COG1047	Peptidyl-prolyl cis-trans
K3X48_RS11055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K3X48_RS11060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K3X48_RS11065	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K3X48_RS11070	COG2267	carboxylic ester hydrolase activity
K3X48_RS11105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K3X48_RS11115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3X48_RS11140	COG2824	Alkylphosphonate utilization operon protein PhnA
K3X48_RS11160	COG0481	GTPase activity
K3X48_RS11180	COG1105	Belongs to the carbohydrate kinase PfkB family
K3X48_RS11190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K3X48_RS11200	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K3X48_RS11215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K3X48_RS11225	COG1132	(ABC) transporter
K3X48_RS11230	COG1703	isobutyryl-CoA mutase activity
K3X48_RS11235	COG1643	Atp-dependent helicase
K3X48_RS11245	COG0306	phosphate transporter
K3X48_RS11255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K3X48_RS11260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K3X48_RS11280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3X48_RS11300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K3X48_RS11300	COG0512	Glutamine amidotransferase of anthranilate synthase
K3X48_RS11310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K3X48_RS11325	COG0346	lactoylglutathione lyase activity
K3X48_RS11345	COG0778	Nitroreductase
K3X48_RS11355	COG1872	DUF167
K3X48_RS11360	COG3152	Membrane
K3X48_RS11365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K3X48_RS11390	COG0540	Belongs to the ATCase OTCase family
K3X48_RS11400	COG1573	uracil-dna glycosylase
K3X48_RS11405	COG0521	Mo-molybdopterin cofactor biosynthetic process
K3X48_RS11415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3X48_RS11425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K3X48_RS11445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K3X48_RS11450	COG0142	geranyltranstransferase activity
K3X48_RS11475	COG0583	DNA-binding transcription factor activity
K3X48_RS11485	COG1028	Short-chain dehydrogenase reductase Sdr
K3X48_RS11500	COG2818	Glycosylase
K3X48_RS11505	COG2951	lytic endotransglycosylase activity
K3X48_RS11520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3X48_RS11525	COG0165	Argininosuccinate lyase
K3X48_RS11530	COG0019	diaminopimelate decarboxylase activity
K3X48_RS11540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K3X48_RS11565	COG1162	GTPase activity
K3X48_RS11575	COG0737	Belongs to the 5'-nucleotidase family
K3X48_RS11580	COG2816	NAD+ diphosphatase activity
K3X48_RS11590	COG0077	Prephenate dehydratase
K3X48_RS11595	COG3474	cytochrome
K3X48_RS11600	COG4166	transmembrane transport
K3X48_RS11605	COG4174	ABC transporter (Permease)
K3X48_RS11610	COG4239	(ABC) transporter, permease
K3X48_RS11615	COG4172	Belongs to the ABC transporter superfamily
K3X48_RS11620	COG1686	Belongs to the peptidase S11 family
K3X48_RS11625	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K3X48_RS11630	COG2813	Specifically methylates the guanine in position
K3X48_RS11640	COG0408	coproporphyrinogen oxidase activity
K3X48_RS11650	COG1846	Transcriptional regulator
K3X48_RS11655	COG0183	Belongs to the thiolase family
K3X48_RS11660	COG0181	hydroxymethylbilane synthase activity
K3X48_RS11665	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K3X48_RS11675	COG0513	Belongs to the DEAD box helicase family
K3X48_RS11680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K3X48_RS11695	COG0288	reversible hydration of carbon dioxide
K3X48_RS11705	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K3X48_RS11710	COG0791	NLP P60 protein
K3X48_RS11720	COG2050	protein possibly involved in aromatic compounds catabolism
K3X48_RS11745	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K3X48_RS11760	COG0679	Auxin Efflux Carrier
K3X48_RS11770	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K3X48_RS11775	COG1671	Belongs to the UPF0178 family
K3X48_RS11785	COG1280	lysine exporter protein (LysE YggA)
K3X48_RS11790	COG2897	thiosulfate sulfurtransferase activity
K3X48_RS11800	COG0004	ammonium transporteR
K3X48_RS11805	COG0347	Belongs to the P(II) protein family
K3X48_RS11835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K3X48_RS11845	COG0584	glycerophosphoryl diester phosphodiesterase
K3X48_RS11855	COG2154	pterin-4-alpha-carbinolamine dehydratase
K3X48_RS11865	COG0742	ribosomal rna small subunit methyltransferase
K3X48_RS11870	COG0024	Methionine aminopeptidase
K3X48_RS11875	COG1489	DNA binding
K3X48_RS11880	COG1058	Belongs to the CinA family
K3X48_RS11880	COG1546	Belongs to the CinA family
K3X48_RS11900	COG0583	DNA-binding transcription factor activity
K3X48_RS11910	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X48_RS11910	COG1902	pentaerythritol trinitrate reductase activity
K3X48_RS11935	COG1266	CAAX protease self-immunity
K3X48_RS11940	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K3X48_RS11945	COG0285	dihydrofolate synthase activity
K3X48_RS11960	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K3X48_RS11975	COG0686	Belongs to the AlaDH PNT family
K3X48_RS11985	COG0668	transmembrane transport
K3X48_RS11990	COG1970	mechanosensitive ion channel activity
K3X48_RS12000	COG0072	phenylalanine-tRNA ligase activity
K3X48_RS12000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3X48_RS12015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K3X48_RS12020	COG1595	DNA-templated transcription, initiation
K3X48_RS12025	COG3795	YCII-related domain
K3X48_RS12035	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K3X48_RS12040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K3X48_RS12050	COG0469	pyruvate kinase activity
K3X48_RS12075	COG3384	dioxygenase
K3X48_RS12090	COG4948	Mandelate Racemase Muconate Lactonizing
K3X48_RS12115	COG0825	malonyl-CoA metabolic process
K3X48_RS12135	COG2884	Cell division ATP-binding protein ftsE
K3X48_RS12170	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
K3X48_RS12180	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K3X48_RS12190	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K3X48_RS12205	COG0284	orotidine-5'-phosphate decarboxylase activity
K3X48_RS12225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K3X48_RS12240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K3X48_RS12255	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K3X48_RS12275	COG0559	Belongs to the binding-protein-dependent transport system permease family
K3X48_RS12305	COG3383	formate dehydrogenase (NAD+) activity
K3X48_RS12345	COG0612	Peptidase, M16
K3X48_RS12350	COG0612	Peptidase, M16
K3X48_RS12360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K3X48_RS12365	COG0138	bifunctional purine biosynthesis protein purh
K3X48_RS12385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K3X48_RS12390	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K3X48_RS12395	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K3X48_RS12400	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K3X48_RS12420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K3X48_RS12430	COG1185	polyribonucleotide nucleotidyltransferase activity
K3X48_RS12440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K3X48_RS12445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K3X48_RS12455	COG0560	Phosphoserine phosphatase
K3X48_RS12480	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K3X48_RS12500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3X48_RS12505	COG2171	N-acyltransferase activity
K3X48_RS12545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K3X48_RS12550	COG0557	exoribonuclease II activity
K3X48_RS12555	COG2951	lytic endotransglycosylase activity
K3X48_RS12575	COG1051	belongs to the nudix hydrolase family
K3X48_RS12580	COG0793	Belongs to the peptidase S41A family
K3X48_RS12590	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K3X48_RS12600	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K3X48_RS12605	COG0799	negative regulation of ribosome biogenesis
K3X48_RS12615	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3X48_RS12615	COG3264	Mechanosensitive ion channel
K3X48_RS12620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K3X48_RS12625	COG0066	3-isopropylmalate dehydratase activity
K3X48_RS12640	COG0473	3-isopropylmalate dehydrogenase activity
K3X48_RS12660	COG1960	acyl-CoA dehydrogenase activity
K3X48_RS12665	COG2329	Antibiotic biosynthesis monooxygenase
K3X48_RS12675	COG2233	PERMEase
K3X48_RS12680	COG0277	FAD linked oxidase domain protein
K3X48_RS12695	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3X48_RS12700	COG2186	Transcriptional regulator
K3X48_RS12705	COG0560	Phosphoserine phosphatase
K3X48_RS12715	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K3X48_RS12720	COG0765	amino acid transport
K3X48_RS12725	COG1126	abc transporter atp-binding protein
K3X48_RS12740	COG4608	Belongs to the ABC transporter superfamily
K3X48_RS12745	COG0444	Belongs to the ABC transporter superfamily
K3X48_RS12750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X48_RS12755	COG0601	transmembrane transport
K3X48_RS12760	COG0747	negative chemotaxis
K3X48_RS12765	COG1802	Transcriptional regulator
K3X48_RS12790	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K3X48_RS12795	COG4172	Belongs to the ABC transporter superfamily
K3X48_RS12805	COG0601	transmembrane transport
K3X48_RS12815	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X48_RS12825	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3X48_RS12845	COG0798	PFAM Bile acid sodium symporter
K3X48_RS12850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K3X48_RS12860	COG1349	DNA-binding transcription factor activity
K3X48_RS12875	COG2010	Cytochrome c
K3X48_RS12895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K3X48_RS12900	COG2010	Cytochrome c
K3X48_RS12905	COG3391	amine dehydrogenase activity
K3X48_RS12910	COG1522	sequence-specific DNA binding
K3X48_RS12925	COG0535	radical SAM domain protein
K3X48_RS12940	COG2197	response regulator
K3X48_RS12950	COG1024	Enoyl-CoA hydratase
K3X48_RS12980	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K3X48_RS12995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K3X48_RS13015	COG1766	The M ring may be actively involved in energy transduction
K3X48_RS13025	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K3X48_RS13030	COG1338	Plays a role in the flagellum-specific transport system
K3X48_RS13035	COG4948	Mandelate Racemase Muconate Lactonizing
K3X48_RS13045	COG0583	DNA-binding transcription factor activity
K3X48_RS13050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X48_RS13065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K3X48_RS13080	COG2176	DNA-directed DNA polymerase activity
K3X48_RS13080	COG5002	protein histidine kinase activity
K3X48_RS13085	COG0243	molybdopterin cofactor binding
K3X48_RS13170	COG0183	Belongs to the thiolase family
K3X48_RS13210	COG1674	ftsk spoiiie
K3X48_RS13225	COG0154	amidase activity
K3X48_RS13230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K3X48_RS13240	COG2835	tetraacyldisaccharide 4'-kinase activity
K3X48_RS13255	COG0708	Exodeoxyribonuclease III
K3X48_RS13265	COG0789	Transcriptional regulator
K3X48_RS13275	COG0745	RESPONSE REGULATOR receiver
K3X48_RS13290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K3X48_RS13310	COG0495	leucyl-tRNA aminoacylation
K3X48_RS13325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X48_RS13325	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K3X48_RS13330	COG3264	Mechanosensitive ion channel
K3X48_RS13330	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3X48_RS13335	COG1024	Enoyl-CoA hydratase
K3X48_RS13340	COG4221	oxidoreductase activity
K3X48_RS13345	COG0312	modulator of DNA gyrase
K3X48_RS13350	COG0483	inositol monophosphate 1-phosphatase activity
K3X48_RS13355	COG1609	Transcriptional regulator
K3X48_RS13385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3X48_RS13390	COG1917	Cupin 2, conserved barrel domain protein
K3X48_RS13395	COG0527	aspartate kinase activity
K3X48_RS13405	COG0006	proline dipeptidase activity
K3X48_RS13420	COG4166	transmembrane transport
K3X48_RS13425	COG0601	transmembrane transport
K3X48_RS13430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X48_RS13445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X48_RS13450	COG1012	belongs to the aldehyde dehydrogenase family
K3X48_RS13455	COG1522	sequence-specific DNA binding
K3X48_RS13460	COG2423	ornithine cyclodeaminase activity
K3X48_RS13465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3X48_RS13470	COG0006	proline dipeptidase activity
K3X48_RS13480	COG1802	Transcriptional regulator
K3X48_RS13515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K3X48_RS13520	COG0297	glycogen (starch) synthase activity
K3X48_RS13530	COG0438	transferase activity, transferring glycosyl groups
K3X48_RS13555	COG0438	transferase activity, transferring glycosyl groups
K3X48_RS13580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K3X48_RS13585	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X48_RS13605	COG0662	Cupin 2, conserved barrel domain protein
K3X48_RS13605	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K3X48_RS13625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K3X48_RS13645	COG1194	a g-specific adenine glycosylase
K3X48_RS13655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K3X48_RS13660	COG3034	peptidoglycan biosynthetic process
K3X48_RS13665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K3X48_RS13670	COG0617	tRNA 3'-terminal CCA addition
K3X48_RS13675	COG0494	nUDIX hydrolase
K3X48_RS13685	COG0745	RESPONSE REGULATOR receiver
K3X48_RS13695	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3X48_RS13705	COG0137	argininosuccinate synthase activity
K3X48_RS13720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3X48_RS13725	COG0473	3-isopropylmalate dehydrogenase activity
K3X48_RS13740	COG0435	Glutathione S-transferase
K3X48_RS13745	COG0281	malic enzyme
K3X48_RS13745	COG0280	phosphate acetyltransferase
K3X48_RS13750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K3X48_RS13755	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K3X48_RS13760	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
K3X48_RS13765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K3X48_RS13770	COG1420	regulation of RNA biosynthetic process
K3X48_RS13775	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K3X48_RS13780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K3X48_RS13785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3X48_RS13800	COG0357	Ribosomal RNA small subunit methyltransferase G
K3X48_RS13805	COG0445	tRNA wobble uridine modification
K3X48_RS13810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K3X48_RS13815	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K3X48_RS13820	COG1981	membrane
K3X48_RS13825	COG0424	maF-like protein
K3X48_RS13830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K3X48_RS13835	COG0237	dephospho-CoA kinase activity
K3X48_RS13840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K3X48_RS13850	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K3X48_RS13855	COG3030	protein affecting phage T7 exclusion by the F plasmid
K3X48_RS13880	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K3X48_RS13885	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K3X48_RS13900	COG1040	competence protein
K3X48_RS13910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K3X48_RS13925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K3X48_RS13945	COG0779	Required for maturation of 30S ribosomal subunits
K3X48_RS13960	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K3X48_RS13970	COG0494	nUDIX hydrolase
K3X48_RS13975	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K3X48_RS13980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K3X48_RS13985	COG0653	protein targeting
K3X48_RS13995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K3X48_RS14000	COG2003	Belongs to the UPF0758 family
K3X48_RS14005	COG0484	heat shock protein binding
K3X48_RS14010	COG0443	Heat shock 70 kDa protein
K3X48_RS14030	COG1218	3'(2'),5'-bisphosphate nucleotidase
K3X48_RS14035	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K3X48_RS14065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K3X48_RS14070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K3X48_RS14075	COG1137	ATPase activity
K3X48_RS14095	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3X48_RS14105	COG0437	4 iron, 4 sulfur cluster binding
K3X48_RS14110	COG0243	molybdopterin cofactor binding
K3X48_RS14115	COG0657	acetylesterase activity
K3X48_RS14125	COG1663	tetraacyldisaccharide 4'-kinase activity
K3X48_RS14150	COG0714	Associated with various cellular activities
K3X48_RS14170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3X48_RS14185	COG2226	methyltransferase
K3X48_RS14200	COG4263	nitrous-oxide reductase activity
K3X48_RS14225	COG0437	4 iron, 4 sulfur cluster binding
K3X48_RS14230	COG0348	domain, Protein
K3X48_RS14255	COG1999	signal sequence binding
K3X48_RS14280	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K3X48_RS14285	COG3178	'Phosphotransferase
K3X48_RS14290	COG0802	atpase or kinase
K3X48_RS14305	COG1999	signal sequence binding
K3X48_RS14310	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K3X48_RS14325	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K3X48_RS14335	COG1442	glycosyl transferase family 8
K3X48_RS14335	COG1216	Glycosyl transferase, family 2
K3X48_RS14345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K3X48_RS14350	COG0133	tryptophan synthase activity
K3X48_RS14355	COG1652	LysM domain
K3X48_RS14380	COG2350	Protein conserved in bacteria
K3X48_RS14385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K3X48_RS14390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K3X48_RS14415	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K3X48_RS14440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X48_RS14460	COG5598	trimethylamine methyltransferase
K3X48_RS14465	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X48_RS14465	COG1902	pentaerythritol trinitrate reductase activity
K3X48_RS14470	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X48_RS14470	COG1902	pentaerythritol trinitrate reductase activity
K3X48_RS14475	COG0129	dihydroxy-acid dehydratase activity
K3X48_RS14485	COG2175	clavaminate synthase activity
K3X48_RS14505	COG3243	poly(R)-hydroxyalkanoic acid synthase
K3X48_RS14520	COG1228	amidohydrolase
K3X48_RS14525	COG2986	histidine ammonia-lyase
K3X48_RS14540	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3X48_RS14550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X48_RS14560	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K3X48_RS14565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3X48_RS14570	COG2808	Putative FMN-binding domain
K3X48_RS14615	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K3X48_RS14630	COG1028	Short-chain dehydrogenase reductase Sdr
K3X48_RS14635	COG0697	spore germination
K3X48_RS14640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K3X48_RS14645	COG1418	mRNA catabolic process
K3X48_RS14665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K3X48_RS14670	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K3X48_RS14680	COG1960	acyl-CoA dehydrogenase activity
K3X48_RS14705	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K3X48_RS14710	COG0142	geranyltranstransferase activity
K3X48_RS14715	COG1722	exodeoxyribonuclease VII activity
K3X48_RS14720	COG0123	including yeast histone deacetylase and acetoin utilization protein
K3X48_RS14730	COG0745	RESPONSE REGULATOR receiver
K3X48_RS14735	COG1846	Transcriptional regulator
K3X48_RS14740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K3X48_RS14760	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K3X48_RS14770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K3X48_RS14790	COG1968	undecaprenyl-diphosphatase activity
K3X48_RS14805	COG0564	pseudouridine synthase activity
K3X48_RS14850	COG0179	Fumarylacetoacetate (FAA) hydrolase
K3X48_RS14855	COG0625	glutathione transferase activity
K3X48_RS14860	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K3X48_RS14865	COG1360	Flagellar Motor Protein
K3X48_RS14870	COG4786	Flagellar basal body rod
K3X48_RS14885	COG1706	bacterial-type flagellum-dependent cell motility
K3X48_RS14895	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K3X48_RS14905	COG4786	Flagellar basal body rod
K3X48_RS14910	COG4786	Flagellar basal body rod
K3X48_RS14915	COG1987	bacterial-type flagellum assembly
K3X48_RS14920	COG1677	Flagellar hook-basal body complex protein FliE
K3X48_RS14925	COG1558	bacterial-type flagellum-dependent cell motility
K3X48_RS14975	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K3X48_RS14985	COG2226	methyltransferase
K3X48_RS14995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K3X48_RS15000	COG1024	Enoyl-CoA hydratase
K3X48_RS15005	COG0268	Binds directly to 16S ribosomal RNA
K3X48_RS15010	COG1522	sequence-specific DNA binding
K3X48_RS15015	COG2226	methyltransferase
K3X48_RS15025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X48_RS15025	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K3X48_RS15030	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K3X48_RS15035	COG0156	8-amino-7-oxononanoate synthase activity
K3X48_RS15040	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K3X48_RS15050	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
K3X48_RS15050	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
K3X48_RS15050	COG0506	proline dehydrogenase activity
K3X48_RS15055	COG1522	sequence-specific DNA binding
K3X48_RS15060	COG1049	propionate catabolic process, 2-methylcitrate cycle
K3X48_RS15070	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K3X48_RS15085	COG1183	phosphatidylcholine synthase activity
K3X48_RS15095	COG0310	cobalt ion transport
K3X48_RS15100	COG0310	cobalt ion transport
K3X48_RS15110	COG1122	ATPase activity
K3X48_RS15120	COG0174	glutamine synthetase
K3X48_RS15125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X48_RS15130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X48_RS15135	COG3800	Transcriptional regulator
K3X48_RS15135	COG1396	sequence-specific DNA binding
K3X48_RS15140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3X48_RS15145	COG1960	acyl-CoA dehydrogenase activity
K3X48_RS15150	COG1012	belongs to the aldehyde dehydrogenase family
K3X48_RS15155	COG4566	intracellular signal transduction
K3X48_RS15165	COG2358	TRAP transporter, solute receptor (TAXI family
K3X48_RS15205	COG0395	ABC-type sugar transport system, permease component
K3X48_RS15210	COG1175	transmembrane transport
K3X48_RS15215	COG3842	ATPase activity
K3X48_RS15220	COG3842	ATPase activity
K3X48_RS15310	COG0134	indole-3-glycerol-phosphate synthase activity
K3X48_RS15315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K3X48_RS15320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3X48_RS15325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K3X48_RS15330	COG1960	acyl-CoA dehydrogenase activity
K3X48_RS15345	COG0662	Cupin 2, conserved barrel domain protein
K3X48_RS15355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3X48_RS15355	COG4191	Histidine kinase
K3X48_RS15370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K3X48_RS15380	COG1136	(ABC) transporter
K3X48_RS15390	COG0745	RESPONSE REGULATOR receiver
K3X48_RS15400	COG1280	lysine exporter protein (LysE YggA)
K3X48_RS15455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K3X48_RS15480	COG1450	Type ii and iii secretion system protein
K3X48_RS15590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K3X48_RS15590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X48_RS15600	COG2132	Multicopper oxidase
K3X48_RS15605	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X48_RS15605	COG2010	Cytochrome c
K3X48_RS15650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K3X48_RS15655	COG1376	ErfK ybiS ycfS ynhG family protein
K3X48_RS15660	COG4235	cytochrome complex assembly
K3X48_RS15665	COG3088	subunit of a heme lyase
K3X48_RS15670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3X48_RS15675	COG1138	Cytochrome C-type biogenesis protein
K3X48_RS15705	COG0398	Pfam SNARE associated Golgi protein
K3X48_RS15715	COG1230	cation diffusion facilitator family transporter
K3X48_RS15750	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K3X48_RS15790	COG1215	transferase activity, transferring glycosyl groups
K3X48_RS15810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K3X48_RS15820	COG0698	ribose 5-phosphate isomerase
K3X48_RS15830	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K3X48_RS15855	COG0010	Belongs to the arginase family
K3X48_RS15865	COG2183	response to ionizing radiation
K3X48_RS15875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K3X48_RS15895	COG3842	ATPase activity
K3X48_RS15910	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3X48_RS15915	COG4149	molybdate abc transporter
K3X48_RS15920	COG0725	ABC transporter, periplasmic molybdate-binding protein
K3X48_RS15945	COG1115	amino acid carrier protein
K3X48_RS15955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X48_RS15960	COG0509	glycine decarboxylation via glycine cleavage system
K3X48_RS15965	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K3X48_RS15965	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K3X48_RS15980	COG1192	Involved in chromosome partitioning
K3X48_RS15990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K3X48_RS15995	COG4134	Bacterial extracellular solute-binding protein
K3X48_RS16000	COG4135	transport system, permease component
K3X48_RS16005	COG4136	ATPase activity
K3X48_RS16010	COG1122	ATPase activity
K3X48_RS16015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K3X48_RS16020	COG1268	BioY protein
K3X48_RS16025	COG2351	hydroxyisourate hydrolase activity
K3X48_RS16030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K3X48_RS16055	COG1473	amidohydrolase