locus-tag	class	description
K3X41_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K3X41_RS00040	COG3909	cytochrome
K3X41_RS00045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X41_RS00045	COG2010	Cytochrome c
K3X41_RS00050	COG2132	Multicopper oxidase
K3X41_RS00080	COG1166	arginine decarboxylase activity
K3X41_RS00095	COG0010	Belongs to the arginase family
K3X41_RS00100	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K3X41_RS00115	COG2022	thiamine diphosphate biosynthetic process
K3X41_RS00125	COG0351	phosphomethylpyrimidine kinase
K3X41_RS00135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3X41_RS00150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3X41_RS00155	COG3938	Belongs to the proline racemase family
K3X41_RS00160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X41_RS00165	COG3938	Belongs to the proline racemase family
K3X41_RS00170	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K3X41_RS00175	COG1802	Transcriptional regulator
K3X41_RS00185	COG0028	Belongs to the TPP enzyme family
K3X41_RS00190	COG1349	DNA-binding transcription factor activity
K3X41_RS00205	COG1840	ABC-type Fe3 transport system, periplasmic component
K3X41_RS00210	COG3842	ATPase activity
K3X41_RS00225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K3X41_RS00235	COG1012	belongs to the aldehyde dehydrogenase family
K3X41_RS00250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K3X41_RS00265	COG1283	sodium-dependent phosphate transmembrane transporter activity
K3X41_RS00275	COG0583	DNA-binding transcription factor activity
K3X41_RS00285	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X41_RS00285	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3X41_RS00290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3X41_RS00310	COG0251	oxidation-reduction process
K3X41_RS00325	COG0745	RESPONSE REGULATOR receiver
K3X41_RS00330	COG2205	protein histidine kinase activity
K3X41_RS00350	COG1132	(ABC) transporter
K3X41_RS00355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K3X41_RS00360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3X41_RS00365	COG1960	acyl-CoA dehydrogenase activity
K3X41_RS00370	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X41_RS00390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K3X41_RS00395	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K3X41_RS00400	COG1335	isochorismatase
K3X41_RS00420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K3X41_RS00430	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
K3X41_RS00450	COG0514	ATP-dependent DNA helicase (RecQ)
K3X41_RS00455	COG3022	response to hydroperoxide
K3X41_RS00460	COG4999	Histidine kinase
K3X41_RS00460	COG2205	protein histidine kinase activity
K3X41_RS00460	COG3437	response regulator, receiver
K3X41_RS00460	COG3850	Histidine kinase
K3X41_RS00480	COG0604	alcohol dehydrogenase
K3X41_RS00480	COG1028	Short-chain dehydrogenase reductase Sdr
K3X41_RS00480	COG3321	synthase
K3X41_RS00490	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K3X41_RS00495	COG2814	Major facilitator Superfamily
K3X41_RS00505	COG2267	carboxylic ester hydrolase activity
K3X41_RS00515	COG2423	ornithine cyclodeaminase activity
K3X41_RS00540	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K3X41_RS00620	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
K3X41_RS00630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X41_RS00630	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K3X41_RS00635	COG0697	spore germination
K3X41_RS00640	COG0741	lytic transglycosylase activity
K3X41_RS00645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3X41_RS00655	COG1720	tRNA m6t6A37 methyltransferase activity
K3X41_RS00660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K3X41_RS00670	COG0303	'Molybdopterin
K3X41_RS00675	COG0746	molybdenum cofactor guanylyltransferase activity
K3X41_RS00680	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K3X41_RS00695	COG0583	DNA-binding transcription factor activity
K3X41_RS00735	COG1960	acyl-CoA dehydrogenase activity
K3X41_RS00740	COG0009	L-threonylcarbamoyladenylate synthase
K3X41_RS00745	COG1678	Uncharacterized ACR, COG1678
K3X41_RS00780	COG3119	arylsulfatase activity
K3X41_RS00835	COG0494	nUDIX hydrolase
K3X41_RS00840	COG3034	peptidoglycan biosynthetic process
K3X41_RS00845	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K3X41_RS00860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K3X41_RS00875	COG0328	RNA-DNA hybrid ribonuclease activity
K3X41_RS00885	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K3X41_RS00895	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K3X41_RS00900	COG1758	RNA polymerase activity
K3X41_RS00905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K3X41_RS00915	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K3X41_RS00920	COG1280	lysine exporter protein (LysE YggA)
K3X41_RS00925	COG0736	holo-[acyl-carrier-protein] synthase activity
K3X41_RS00930	COG0681	Belongs to the peptidase S26 family
K3X41_RS00935	COG0571	ribonuclease III activity
K3X41_RS00940	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K3X41_RS00950	COG1381	Involved in DNA repair and RecF pathway recombination
K3X41_RS00990	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K3X41_RS00995	COG0745	RESPONSE REGULATOR receiver
K3X41_RS01000	COG2205	protein histidine kinase activity
K3X41_RS01010	COG1660	Displays ATPase and GTPase activities
K3X41_RS01020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K3X41_RS01030	COG0840	transmembrane signaling receptor activity
K3X41_RS01070	COG0300	oxidoreductase activity
K3X41_RS01080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K3X41_RS01090	COG0501	Belongs to the peptidase M48B family
K3X41_RS01095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K3X41_RS01110	COG0250	Participates in transcription elongation, termination and antitermination
K3X41_RS01115	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K3X41_RS01120	COG0081	regulation of translation
K3X41_RS01125	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K3X41_RS01130	COG0222	ribosome binding
K3X41_RS01135	COG0085	RNA polymerase activity
K3X41_RS01140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K3X41_RS01150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K3X41_RS01155	COG0049	tRNA binding
K3X41_RS01160	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K3X41_RS01165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K3X41_RS01175	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K3X41_RS01180	COG0088	Forms part of the polypeptide exit tunnel
K3X41_RS01185	COG0089	rRNA binding
K3X41_RS01200	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K3X41_RS01205	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K3X41_RS01210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K3X41_RS01215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K3X41_RS01220	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K3X41_RS01260	COG0255	Belongs to the universal ribosomal protein uL29 family
K3X41_RS01265	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K3X41_RS01270	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K3X41_RS01275	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K3X41_RS01280	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K3X41_RS01285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K3X41_RS01290	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K3X41_RS01295	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K3X41_RS01300	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K3X41_RS01305	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K3X41_RS01310	COG1841	ribosomal large subunit assembly
K3X41_RS01325	COG0200	Binds to the 23S rRNA
K3X41_RS01330	COG0201	protein transport
K3X41_RS01335	COG0563	adenylate kinase activity
K3X41_RS01340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K3X41_RS01345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K3X41_RS01350	COG0202	RNA polymerase activity
K3X41_RS01355	COG0203	ribosomal protein L17
K3X41_RS01365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K3X41_RS01380	COG0564	pseudouridine synthase activity
K3X41_RS01385	COG0546	phosphoglycolate phosphatase activity
K3X41_RS01395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3X41_RS01400	COG4597	amino acid ABC transporter
K3X41_RS01405	COG0765	amino acid transport
K3X41_RS01410	COG1126	abc transporter atp-binding protein
K3X41_RS01435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K3X41_RS01440	COG1028	Short-chain dehydrogenase reductase Sdr
K3X41_RS01445	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K3X41_RS01455	COG0706	membrane insertase activity
K3X41_RS01460	COG5001	Diguanylate cyclase
K3X41_RS01465	COG0037	tRNA processing
K3X41_RS01480	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K3X41_RS01485	COG0594	ribonuclease P activity
K3X41_RS01490	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K3X41_RS01495	COG3734	2-keto-3-deoxy-galactonokinase
K3X41_RS01520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K3X41_RS01530	COG2885	chlorophyll binding
K3X41_RS01530	COG3047	cAMP biosynthetic process
K3X41_RS01550	COG1739	Uncharacterized protein family UPF0029
K3X41_RS01565	COG1435	thymidine kinase activity
K3X41_RS01575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3X41_RS01595	COG1136	(ABC) transporter
K3X41_RS01600	COG0438	transferase activity, transferring glycosyl groups
K3X41_RS01615	COG0187	DNA topoisomerase II activity
K3X41_RS01620	COG4335	DNA alkylation repair
K3X41_RS01625	COG0101	tRNA pseudouridine synthase activity
K3X41_RS01630	COG3106	COG3106 Predicted ATPase
K3X41_RS01640	COG3768	UPF0283 membrane protein
K3X41_RS01665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K3X41_RS01670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K3X41_RS01675	COG1131	(ABC) transporter
K3X41_RS01680	COG0842	Transport permease protein
K3X41_RS01685	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X41_RS01685	COG0616	signal peptide processing
K3X41_RS01705	COG0322	excinuclease ABC activity
K3X41_RS01710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K3X41_RS01720	COG0314	molybdopterin synthase activity
K3X41_RS01730	COG1183	phosphatidylcholine synthase activity
K3X41_RS01745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K3X41_RS01755	COG2391	methyltransferase activity
K3X41_RS01765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3X41_RS01770	COG2264	protein methyltransferase activity
K3X41_RS01795	COG2814	Major facilitator Superfamily
K3X41_RS01805	COG1045	serine acetyltransferase
K3X41_RS01810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3X41_RS01820	COG1570	exodeoxyribonuclease VII activity
K3X41_RS01830	COG0590	tRNA wobble adenosine to inosine editing
K3X41_RS01850	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K3X41_RS01855	COG0154	amidase activity
K3X41_RS01865	COG3023	N-Acetylmuramoyl-L-alanine amidase
K3X41_RS01875	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K3X41_RS01890	COG0670	Belongs to the BI1 family
K3X41_RS01900	COG0583	DNA-binding transcription factor activity
K3X41_RS01910	COG0604	alcohol dehydrogenase
K3X41_RS01910	COG3321	synthase
K3X41_RS01910	COG1028	Short-chain dehydrogenase reductase Sdr
K3X41_RS01920	COG0483	inositol monophosphate 1-phosphatase activity
K3X41_RS01930	COG0402	S-adenosylhomocysteine deaminase activity
K3X41_RS01935	COG2239	Acts as a magnesium transporter
K3X41_RS01940	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K3X41_RS01945	COG3273	potassium ion transport
K3X41_RS01945	COG0471	metal ion transport
K3X41_RS01950	COG1280	lysine exporter protein (LysE YggA)
K3X41_RS01960	COG1846	Transcriptional regulator
K3X41_RS01970	COG0217	transcriptional regulatory protein
K3X41_RS01980	COG0778	Nitroreductase
K3X41_RS01995	COG0747	negative chemotaxis
K3X41_RS02000	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K3X41_RS02005	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K3X41_RS02050	COG1012	belongs to the aldehyde dehydrogenase family
K3X41_RS02065	COG0601	transmembrane transport
K3X41_RS02070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X41_RS02080	COG4608	Belongs to the ABC transporter superfamily
K3X41_RS02090	COG1042	CoA-binding domain protein
K3X41_RS02090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K3X41_RS02090	COG0045	succinate-CoA ligase (ADP-forming) activity
K3X41_RS02095	COG0123	including yeast histone deacetylase and acetoin utilization protein
K3X41_RS02110	COG0667	Aldo Keto reductase
K3X41_RS02120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K3X41_RS02130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3X41_RS02135	COG1079	Belongs to the binding-protein-dependent transport system permease family
K3X41_RS02140	COG4603	Belongs to the binding-protein-dependent transport system permease family
K3X41_RS02145	COG3845	ABC transporter
K3X41_RS02155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X41_RS02175	COG2900	Belongs to the SlyX family
K3X41_RS02180	COG0124	histidyl-tRNA synthetase
K3X41_RS02185	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K3X41_RS02190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K3X41_RS02195	COG0180	Tryptophanyl-tRNA synthetase
K3X41_RS02210	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K3X41_RS02220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K3X41_RS02225	COG0792	nuclease activity
K3X41_RS02230	COG0189	ligase activity
K3X41_RS02240	COG0606	chelatase, subunit chli
K3X41_RS02265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K3X41_RS02270	COG0756	dUTP diphosphatase activity
K3X41_RS02275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K3X41_RS02290	COG0765	amino acid transport
K3X41_RS02295	COG0339	signal peptide processing
K3X41_RS02300	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K3X41_RS02365	COG3118	belongs to the thioredoxin family
K3X41_RS02370	COG0509	glycine decarboxylation via glycine cleavage system
K3X41_RS02380	COG0534	Mate efflux family protein
K3X41_RS02390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3X41_RS02420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3X41_RS02440	COG0768	penicillin binding
K3X41_RS02445	COG0772	Belongs to the SEDS family
K3X41_RS02485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K3X41_RS02505	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K3X41_RS02510	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K3X41_RS02515	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K3X41_RS02520	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K3X41_RS02525	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K3X41_RS02555	COG0596	Alpha beta hydrolase
K3X41_RS02555	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X41_RS02565	COG2983	Belongs to the UPF0260 family
K3X41_RS02575	COG0196	riboflavin kinase activity
K3X41_RS02580	COG2030	dehydratase
K3X41_RS02595	COG1227	inorganic diphosphatase activity
K3X41_RS02605	COG1858	cytochrome C peroxidase
K3X41_RS02615	COG0459	protein refolding
K3X41_RS02630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3X41_RS02635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3X41_RS02660	COG2010	Cytochrome c
K3X41_RS02665	COG0348	domain, Protein
K3X41_RS02685	COG2197	response regulator
K3X41_RS02695	COG4181	ATPase activity
K3X41_RS02700	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K3X41_RS02735	COG2030	dehydratase
K3X41_RS02745	COG2301	Belongs to the HpcH HpaI aldolase family
K3X41_RS02760	COG0039	L-malate dehydrogenase activity
K3X41_RS02770	COG0045	succinate-CoA ligase (ADP-forming) activity
K3X41_RS02780	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K3X41_RS02785	COG0567	Dehydrogenase, E1 component
K3X41_RS02790	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X41_RS02835	COG0642	Histidine kinase
K3X41_RS02865	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K3X41_RS02885	COG0356	it plays a direct role in the translocation of protons across the membrane
K3X41_RS02890	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K3X41_RS02895	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K3X41_RS02900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K3X41_RS02910	COG2186	Transcriptional regulator
K3X41_RS02915	COG2885	chlorophyll binding
K3X41_RS02925	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K3X41_RS02930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3X41_RS02935	COG1765	OsmC-like protein
K3X41_RS02960	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3X41_RS02960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3X41_RS02980	COG3622	Belongs to the hyi family
K3X41_RS02990	COG0714	Associated with various cellular activities
K3X41_RS03010	COG0277	FAD linked oxidase domain protein
K3X41_RS03015	COG0277	FAD linked oxidase domain protein
K3X41_RS03020	COG0247	lactate metabolic process
K3X41_RS03030	COG0071	Belongs to the small heat shock protein (HSP20) family
K3X41_RS03040	COG3191	aminopeptidase activity
K3X41_RS03050	COG3214	Protein conserved in bacteria
K3X41_RS03060	COG1012	belongs to the aldehyde dehydrogenase family
K3X41_RS03070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X41_RS03080	COG0489	protein tyrosine kinase activity
K3X41_RS03080	COG2151	metal-sulfur cluster biosynthetic enzyme
K3X41_RS03090	COG0254	rRNA binding
K3X41_RS03095	COG0335	large ribosomal subunit rRNA binding
K3X41_RS03100	COG0336	Belongs to the RNA methyltransferase TrmD family
K3X41_RS03110	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K3X41_RS03115	COG0778	Nitroreductase
K3X41_RS03120	COG0228	four-way junction DNA binding
K3X41_RS03140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K3X41_RS03160	COG1054	Belongs to the UPF0176 family
K3X41_RS03170	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K3X41_RS03200	COG1309	transcriptional regulator
K3X41_RS03205	COG3119	arylsulfatase activity
K3X41_RS03210	COG1012	belongs to the aldehyde dehydrogenase family
K3X41_RS03225	COG3800	Transcriptional regulator
K3X41_RS03225	COG1396	sequence-specific DNA binding
K3X41_RS03230	COG2814	Major facilitator Superfamily
K3X41_RS03235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K3X41_RS03260	COG4770	biotin carboxylase activity
K3X41_RS03270	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X41_RS03270	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X41_RS03280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X41_RS03285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K3X41_RS03305	COG0248	Ppx GppA phosphatase
K3X41_RS03310	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K3X41_RS03320	COG0628	permease
K3X41_RS03335	COG0442	prolyl-tRNA aminoacylation
K3X41_RS03345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K3X41_RS03350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K3X41_RS03370	COG0529	Catalyzes the synthesis of activated sulfate
K3X41_RS03370	COG2046	Belongs to the sulfate adenylyltransferase family
K3X41_RS03380	COG0492	ferredoxin-NADP+ reductase activity
K3X41_RS03385	COG1522	sequence-specific DNA binding
K3X41_RS03395	COG1496	oxidoreductase activity
K3X41_RS03405	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K3X41_RS03420	COG1573	uracil-dna glycosylase
K3X41_RS03435	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X41_RS03450	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K3X41_RS03460	COG0463	Glycosyl transferase, family 2
K3X41_RS03505	COG0174	glutamine synthetase
K3X41_RS03530	COG0022	dehydrogenase e1 component
K3X41_RS03535	COG0583	DNA-binding transcription factor activity
K3X41_RS03545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X41_RS03550	COG1012	belongs to the aldehyde dehydrogenase family
K3X41_RS03555	COG0583	DNA-binding transcription factor activity
K3X41_RS03565	COG0556	nucleotide-excision repair
K3X41_RS03585	COG3739	integral membrane protein
K3X41_RS03595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K3X41_RS03610	COG2204	response regulator
K3X41_RS03620	COG0280	phosphate acetyltransferase
K3X41_RS03620	COG0281	malic enzyme
K3X41_RS03630	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K3X41_RS03635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K3X41_RS03640	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K3X41_RS03655	COG0318	PFAM AMP-dependent synthetase and ligase
K3X41_RS03670	COG1024	Enoyl-CoA hydratase
K3X41_RS03670	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X41_RS03680	COG0183	Belongs to the thiolase family
K3X41_RS03685	COG0625	glutathione transferase activity
K3X41_RS03695	COG1960	acyl-CoA dehydrogenase activity
K3X41_RS03730	COG0534	Mate efflux family protein
K3X41_RS03735	COG1393	Belongs to the ArsC family
K3X41_RS03750	COG3257	ureidoglycine aminohydrolase activity
K3X41_RS03760	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
K3X41_RS03770	COG0737	Belongs to the 5'-nucleotidase family
K3X41_RS03780	COG2135	peptidase activity
K3X41_RS03785	COG0154	amidase activity
K3X41_RS03790	COG0318	PFAM AMP-dependent synthetase and ligase
K3X41_RS03795	COG0174	glutamine synthetase
K3X41_RS03800	COG1177	transmembrane transport
K3X41_RS03805	COG1176	ABC-type spermidine putrescine transport system, permease component I
K3X41_RS03810	COG3842	ATPase activity
K3X41_RS03840	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K3X41_RS03845	COG0602	queuosine metabolic process
K3X41_RS03850	COG0720	synthase
K3X41_RS03855	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K3X41_RS03865	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K3X41_RS03880	COG1492	cobalamin metabolic process
K3X41_RS03890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K3X41_RS03900	COG0354	folic acid binding
K3X41_RS03905	COG1132	(ABC) transporter
K3X41_RS03920	COG0525	valine-tRNA ligase activity
K3X41_RS03925	COG0033	Phosphoglucomutase
K3X41_RS03935	COG0019	diaminopimelate decarboxylase activity
K3X41_RS03950	COG0583	DNA-binding transcription factor activity
K3X41_RS03955	COG0483	inositol monophosphate 1-phosphatase activity
K3X41_RS03980	COG1136	(ABC) transporter
K3X41_RS04000	COG3842	ATPase activity
K3X41_RS04010	COG1176	ABC-type spermidine putrescine transport system, permease component I
K3X41_RS04015	COG1177	transmembrane transport
K3X41_RS04020	COG0740	serine-type endopeptidase activity
K3X41_RS04025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K3X41_RS04045	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K3X41_RS04050	COG0439	Biotin carboxylase
K3X41_RS04065	COG1309	transcriptional regulator
K3X41_RS04080	COG0318	PFAM AMP-dependent synthetase and ligase
K3X41_RS04090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X41_RS04095	COG0410	ABC transporter
K3X41_RS04120	COG1396	sequence-specific DNA binding
K3X41_RS04120	COG3800	Transcriptional regulator
K3X41_RS04125	COG0745	RESPONSE REGULATOR receiver
K3X41_RS04135	COG2205	protein histidine kinase activity
K3X41_RS04145	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K3X41_RS04160	COG3750	Belongs to the UPF0335 family
K3X41_RS04165	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K3X41_RS04170	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K3X41_RS04265	COG0515	serine threonine protein kinase
K3X41_RS04265	COG2815	serine threonine protein kinase
K3X41_RS04315	COG0840	transmembrane signaling receptor activity
K3X41_RS04335	COG0028	Belongs to the TPP enzyme family
K3X41_RS04340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3X41_RS04350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X41_RS04355	COG0519	Catalyzes the synthesis of GMP from XMP
K3X41_RS04355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3X41_RS04390	COG0488	(ABC) transporter
K3X41_RS04400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K3X41_RS04410	COG0625	glutathione transferase activity
K3X41_RS04420	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K3X41_RS04435	COG2326	polyphosphate kinase activity
K3X41_RS04440	COG2951	lytic endotransglycosylase activity
K3X41_RS04445	COG0534	Mate efflux family protein
K3X41_RS04495	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K3X41_RS04505	COG1278	Cold shock
K3X41_RS04510	COG1393	Belongs to the ArsC family
K3X41_RS04530	COG3220	belongs to the UPF0276 family
K3X41_RS04540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K3X41_RS04555	COG2267	carboxylic ester hydrolase activity
K3X41_RS04580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K3X41_RS04585	COG0303	'Molybdopterin
K3X41_RS04590	COG0315	cyclic pyranopterin monophosphate synthase activity
K3X41_RS04600	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K3X41_RS04605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K3X41_RS04630	COG0148	phosphopyruvate hydratase activity
K3X41_RS04635	COG0697	spore germination
K3X41_RS04645	COG0384	phenazine biosynthesis protein PhzF
K3X41_RS04660	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K3X41_RS04665	COG0456	acetyltransferase
K3X41_RS04670	COG1957	nucleoside hydrolase
K3X41_RS04680	COG2081	HI0933 family
K3X41_RS04685	COG0316	Belongs to the HesB IscA family
K3X41_RS04690	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K3X41_RS04695	COG0018	arginyl-trna synthetase
K3X41_RS04705	COG1472	Belongs to the glycosyl hydrolase 3 family
K3X41_RS04710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K3X41_RS04715	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K3X41_RS04725	COG0717	Belongs to the dCTP deaminase family
K3X41_RS04740	COG0776	regulation of translation
K3X41_RS04745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K3X41_RS04750	COG0416	fatty acid biosynthetic process
K3X41_RS04755	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K3X41_RS04775	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3X41_RS04785	COG0488	(ABC) transporter
K3X41_RS04795	COG1272	protein, Hemolysin III
K3X41_RS04800	COG0076	glutamate decarboxylase activity
K3X41_RS04805	COG0149	triose-phosphate isomerase activity
K3X41_RS04810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K3X41_RS04815	COG0316	Belongs to the HesB IscA family
K3X41_RS04830	COG2151	metal-sulfur cluster biosynthetic enzyme
K3X41_RS04835	COG0343	queuine tRNA-ribosyltransferase activity
K3X41_RS04845	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K3X41_RS04870	COG0406	alpha-ribazole phosphatase activity
K3X41_RS04895	COG0156	8-amino-7-oxononanoate synthase activity
K3X41_RS04905	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K3X41_RS04915	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K3X41_RS04925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X41_RS04935	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X41_RS04935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X41_RS04980	COG2962	Rard protein
K3X41_RS04995	COG5265	(ABC) transporter
K3X41_RS05000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3X41_RS05020	COG1160	GTP binding
K3X41_RS05040	COG4221	oxidoreductase activity
K3X41_RS05055	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K3X41_RS05080	COG1127	ABC transporter
K3X41_RS05085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K3X41_RS05115	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K3X41_RS05135	COG0544	peptidyl-prolyl cis-trans isomerase activity
K3X41_RS05145	COG0359	binds to the 23S rRNA
K3X41_RS05150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K3X41_RS05155	COG0360	Binds together with S18 to 16S ribosomal RNA
K3X41_RS05165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K3X41_RS05175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3X41_RS05180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K3X41_RS05185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K3X41_RS05200	COG4695	Portal protein
K3X41_RS05290	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X41_RS05295	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X41_RS05295	COG0022	dehydrogenase e1 component
K3X41_RS05300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K3X41_RS05310	COG3588	fructose-bisphosphate aldolase
K3X41_RS05340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K3X41_RS05350	COG0436	Aminotransferase
K3X41_RS05355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K3X41_RS05360	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K3X41_RS05370	COG0006	proline dipeptidase activity
K3X41_RS05375	COG1473	amidohydrolase
K3X41_RS05410	COG0826	peptidase U32
K3X41_RS05415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K3X41_RS05420	COG0308	aminopeptidase N
K3X41_RS05435	COG2155	Conserved Protein
K3X41_RS05440	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K3X41_RS05465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X41_RS05465	COG2010	Cytochrome c
K3X41_RS05480	COG0436	Aminotransferase
K3X41_RS05495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K3X41_RS05515	COG1741	Belongs to the pirin family
K3X41_RS05530	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K3X41_RS05545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K3X41_RS05550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K3X41_RS05565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K3X41_RS05570	COG1181	Belongs to the D-alanine--D-alanine ligase family
K3X41_RS05575	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K3X41_RS05580	COG0849	cell division
K3X41_RS05585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K3X41_RS05590	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K3X41_RS05595	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X41_RS05605	COG0277	FAD linked oxidase domain protein
K3X41_RS05610	COG0038	chloride channel
K3X41_RS05615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K3X41_RS05620	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K3X41_RS05630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K3X41_RS05645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K3X41_RS05660	COG2095	MarC family integral membrane protein
K3X41_RS05665	COG0488	(ABC) transporter
K3X41_RS05670	COG0105	UTP biosynthetic process
K3X41_RS05705	COG0784	Response regulator, receiver
K3X41_RS05705	COG2198	Histidine kinase
K3X41_RS05705	COG2205	protein histidine kinase activity
K3X41_RS05725	COG0730	response to heat
K3X41_RS05775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K3X41_RS05790	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K3X41_RS05800	COG1522	sequence-specific DNA binding
K3X41_RS05830	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3X41_RS05835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3X41_RS05850	COG0433	COG0433 Predicted ATPase
K3X41_RS05855	COG4536	flavin adenine dinucleotide binding
K3X41_RS05865	COG0004	ammonium transporteR
K3X41_RS05915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K3X41_RS05920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K3X41_RS05925	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K3X41_RS05935	COG2166	iron-sulfur cluster assembly
K3X41_RS05950	COG5012	cobalamin binding
K3X41_RS05960	COG0646	methionine synthase
K3X41_RS05960	COG1410	methionine synthase
K3X41_RS05975	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K3X41_RS05980	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K3X41_RS05985	COG0047	phosphoribosylformylglycinamidine synthase activity
K3X41_RS05995	COG2204	response regulator
K3X41_RS06000	COG0457	Tetratricopeptide repeat
K3X41_RS06005	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K3X41_RS06005	COG3743	rRNA binding
K3X41_RS06010	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K3X41_RS06030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K3X41_RS06035	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K3X41_RS06040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K3X41_RS06085	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K3X41_RS06095	COG2321	neutral zinc metallopeptidase
K3X41_RS06120	COG0626	cystathionine gamma-synthase activity
K3X41_RS06180	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K3X41_RS06190	COG1561	YicC-like family, N-terminal region
K3X41_RS06195	COG0194	GDP metabolic process
K3X41_RS06210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K3X41_RS06220	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K3X41_RS06225	COG2867	negative regulation of translational initiation
K3X41_RS06230	COG4974	Belongs to the 'phage' integrase family
K3X41_RS06245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K3X41_RS06250	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K3X41_RS06255	COG1058	Belongs to the CinA family
K3X41_RS06255	COG1546	Belongs to the CinA family
K3X41_RS06265	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K3X41_RS06265	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K3X41_RS06270	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K3X41_RS06275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K3X41_RS06280	COG3852	Histidine kinase
K3X41_RS06285	COG2204	response regulator
K3X41_RS06290	COG5000	phosphorelay sensor kinase activity
K3X41_RS06295	COG2204	response regulator
K3X41_RS06300	COG0569	domain protein
K3X41_RS06305	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K3X41_RS06315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K3X41_RS06325	COG2084	Dehydrogenase
K3X41_RS06345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K3X41_RS06355	COG2814	Major facilitator Superfamily
K3X41_RS06365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K3X41_RS06380	COG1028	Short-chain dehydrogenase reductase Sdr
K3X41_RS06395	COG2313	pseudouridylate synthase activity
K3X41_RS06400	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K3X41_RS06400	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K3X41_RS06410	COG0052	Belongs to the universal ribosomal protein uS2 family
K3X41_RS06415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K3X41_RS06425	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K3X41_RS06445	COG0587	DNA-directed DNA polymerase activity
K3X41_RS06520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X41_RS06525	COG4311	Sarcosine oxidase, delta subunit
K3X41_RS06530	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X41_RS06530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X41_RS06540	COG4977	sequence-specific DNA binding
K3X41_RS06550	COG1012	belongs to the aldehyde dehydrogenase family
K3X41_RS06570	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K3X41_RS06575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K3X41_RS06585	COG0824	Thioesterase
K3X41_RS06585	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X41_RS06590	COG1028	Short-chain dehydrogenase reductase Sdr
K3X41_RS06595	COG3246	L-lysine catabolic process to acetate
K3X41_RS06600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X41_RS06615	COG3831	ATPase activity
K3X41_RS06620	COG0714	Associated with various cellular activities
K3X41_RS06630	COG3552	Protein containing von Willebrand factor type A (VWA) domain
K3X41_RS06640	COG0745	RESPONSE REGULATOR receiver
K3X41_RS06650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K3X41_RS06660	COG0573	inorganic phosphate transmembrane transporter activity
K3X41_RS06675	COG5002	protein histidine kinase activity
K3X41_RS06695	COG5598	trimethylamine methyltransferase
K3X41_RS06700	COG0519	Catalyzes the synthesis of GMP from XMP
K3X41_RS06700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3X41_RS06725	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K3X41_RS06730	COG2326	polyphosphate kinase activity
K3X41_RS06735	COG1309	transcriptional regulator
K3X41_RS06740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K3X41_RS06755	COG0719	Fe-S assembly protein
K3X41_RS06760	COG0396	ATPase activity
K3X41_RS06780	COG0719	Fe-S assembly protein
K3X41_RS06785	COG1104	cysteine desulfurase activity
K3X41_RS06795	COG1959	2 iron, 2 sulfur cluster binding
K3X41_RS06800	COG2945	thiolester hydrolase activity
K3X41_RS06820	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K3X41_RS06825	COG1612	heme a metabolic process
K3X41_RS06830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K3X41_RS06840	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K3X41_RS06845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3X41_RS06850	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K3X41_RS06865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K3X41_RS06870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K3X41_RS06875	COG0745	RESPONSE REGULATOR receiver
K3X41_RS06885	COG0482	sulfurtransferase activity
K3X41_RS06895	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3X41_RS06905	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3X41_RS06910	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K3X41_RS06920	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X41_RS06930	COG0750	zinc metalloprotease
K3X41_RS06935	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K3X41_RS06945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K3X41_RS06950	COG0233	cytoplasmic translational termination
K3X41_RS06955	COG0528	UMP kinase activity
K3X41_RS06965	COG2207	Transcriptional regulator
K3X41_RS06970	COG0741	lytic transglycosylase activity
K3X41_RS06975	COG0629	single-stranded DNA binding
K3X41_RS06995	COG1686	Belongs to the peptidase S11 family
K3X41_RS07000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K3X41_RS07010	COG0084	hydrolase, TatD family'
K3X41_RS07035	COG3396	Phenylacetate-CoA oxygenase
K3X41_RS07040	COG3460	Phenylacetate-CoA oxygenase
K3X41_RS07045	COG3396	Phenylacetate-CoA oxygenase
K3X41_RS07050	COG2151	metal-sulfur cluster biosynthetic enzyme
K3X41_RS07055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K3X41_RS07065	COG2030	dehydratase
K3X41_RS07065	COG1012	belongs to the aldehyde dehydrogenase family
K3X41_RS07090	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K3X41_RS07105	COG1024	Enoyl-CoA hydratase
K3X41_RS07110	COG0121	glutamine amidotransferase
K3X41_RS07120	COG1217	gtp-binding protein TYPA
K3X41_RS07130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K3X41_RS07135	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K3X41_RS07145	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K3X41_RS07145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K3X41_RS07150	COG0517	IMP dehydrogenase activity
K3X41_RS07150	COG0516	GMP reductase activity
K3X41_RS07175	COG0542	response to heat
K3X41_RS07195	COG2814	Major facilitator Superfamily
K3X41_RS07220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K3X41_RS07230	COG0129	dihydroxy-acid dehydratase activity
K3X41_RS07235	COG0800	Aldolase
K3X41_RS07245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3X41_RS07250	COG0215	cysteine-tRNA ligase activity
K3X41_RS07335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K3X41_RS07340	COG0737	Belongs to the 5'-nucleotidase family
K3X41_RS07345	COG3258	Cytochrome c
K3X41_RS07365	COG0785	Cytochrome C biogenesis protein
K3X41_RS07380	COG2391	methyltransferase activity
K3X41_RS07405	COG2873	o-acetylhomoserine
K3X41_RS07410	COG2968	Membrane
K3X41_RS07420	COG1522	sequence-specific DNA binding
K3X41_RS07425	COG0840	transmembrane signaling receptor activity
K3X41_RS07430	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K3X41_RS07435	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K3X41_RS07440	COG1329	Transcriptional regulator
K3X41_RS07445	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K3X41_RS07450	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K3X41_RS07475	COG0166	Belongs to the GPI family
K3X41_RS07485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K3X41_RS07515	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K3X41_RS07525	COG1797	cobyrinic acid a,c-diamide synthase activity
K3X41_RS07530	COG2814	Major facilitator Superfamily
K3X41_RS07540	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K3X41_RS07560	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K3X41_RS07565	COG0028	Belongs to the TPP enzyme family
K3X41_RS07570	COG0440	acetolactate synthase activity
K3X41_RS07580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K3X41_RS07600	COG0259	pyridoxamine-phosphate oxidase activity
K3X41_RS07605	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K3X41_RS07610	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K3X41_RS07620	COG2890	protein-(glutamine-N5) methyltransferase activity
K3X41_RS07625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K3X41_RS07640	COG0010	Belongs to the arginase family
K3X41_RS07645	COG1473	amidohydrolase
K3X41_RS07650	COG3956	TIGRFAM MazG family protein
K3X41_RS07655	COG1840	ABC-type Fe3 transport system, periplasmic component
K3X41_RS07680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K3X41_RS07695	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K3X41_RS07705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K3X41_RS07710	COG2833	Protein of unknown function (DUF455)
K3X41_RS07715	COG0739	heme binding
K3X41_RS07730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K3X41_RS07735	COG3842	ATPase activity
K3X41_RS07740	COG0395	ABC-type sugar transport system, permease component
K3X41_RS07745	COG1175	transmembrane transport
K3X41_RS07750	COG1653	transport
K3X41_RS07760	COG0745	RESPONSE REGULATOR receiver
K3X41_RS07770	COG0835	chemotaxis
K3X41_RS07775	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K3X41_RS07780	COG0745	RESPONSE REGULATOR receiver
K3X41_RS07805	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K3X41_RS07810	COG2201	protein-glutamate methylesterase activity
K3X41_RS07815	COG0840	transmembrane signaling receptor activity
K3X41_RS07825	COG0784	Response regulator, receiver
K3X41_RS07825	COG2205	protein histidine kinase activity
K3X41_RS07825	COG5002	protein histidine kinase activity
K3X41_RS07895	COG4964	Belongs to the GSP D family
K3X41_RS07955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K3X41_RS07960	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3X41_RS07960	COG3264	Mechanosensitive ion channel
K3X41_RS07970	COG0494	nUDIX hydrolase
K3X41_RS07980	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K3X41_RS07985	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K3X41_RS07990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K3X41_RS08005	COG0604	alcohol dehydrogenase
K3X41_RS08010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X41_RS08030	COG3738	Protein conserved in bacteria
K3X41_RS08045	COG0114	fumarate hydratase activity
K3X41_RS08075	COG0785	Cytochrome C biogenesis protein
K3X41_RS08080	COG0425	Belongs to the sulfur carrier protein TusA family
K3X41_RS08085	COG1530	ribonuclease E activity
K3X41_RS08090	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K3X41_RS08095	COG1164	Oligoendopeptidase f
K3X41_RS08110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K3X41_RS08140	COG0564	pseudouridine synthase activity
K3X41_RS08175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K3X41_RS08180	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K3X41_RS08185	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K3X41_RS08185	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K3X41_RS08220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K3X41_RS08220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K3X41_RS08230	COG0432	Pfam Uncharacterised protein family UPF0047
K3X41_RS08250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K3X41_RS08255	COG0358	DNA primase activity
K3X41_RS08260	COG1309	transcriptional regulator
K3X41_RS08280	COG1335	isochorismatase
K3X41_RS08285	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K3X41_RS08295	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K3X41_RS08305	COG1984	allophanate hydrolase subunit 2
K3X41_RS08375	COG0824	Thioesterase
K3X41_RS08375	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X41_RS08385	COG3246	L-lysine catabolic process to acetate
K3X41_RS08395	COG0667	Aldo Keto reductase
K3X41_RS08400	COG1028	Short-chain dehydrogenase reductase Sdr
K3X41_RS08425	COG0513	Belongs to the DEAD box helicase family
K3X41_RS08435	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K3X41_RS08445	COG1007	ATP synthesis coupled electron transport
K3X41_RS08460	COG0713	ATP synthesis coupled electron transport
K3X41_RS08475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3X41_RS08480	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K3X41_RS08515	COG0649	NAD binding
K3X41_RS08525	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3X41_RS08530	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3X41_RS08540	COG1024	Enoyl-CoA hydratase
K3X41_RS08555	COG4770	biotin carboxylase activity
K3X41_RS08560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K3X41_RS08570	COG1960	acyl-CoA dehydrogenase activity
K3X41_RS08580	COG0546	phosphoglycolate phosphatase activity
K3X41_RS08585	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K3X41_RS08605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X41_RS08615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K3X41_RS08620	COG1473	amidohydrolase
K3X41_RS08625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X41_RS08645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K3X41_RS08655	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K3X41_RS08670	COG0275	rRNA processing
K3X41_RS08675	COG2001	Belongs to the MraZ family
K3X41_RS08680	COG0489	protein tyrosine kinase activity
K3X41_RS08690	COG0210	DNA helicase
K3X41_RS08695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K3X41_RS08695	COG1754	DNA topoisomerase type I activity
K3X41_RS08695	COG1754	DNA topoisomerase type I activity
K3X41_RS08695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K3X41_RS08700	COG3273	potassium ion transport
K3X41_RS08700	COG0471	metal ion transport
K3X41_RS08725	COG2226	methyltransferase
K3X41_RS08735	COG0277	FAD linked oxidase domain protein
K3X41_RS08740	COG1028	Short-chain dehydrogenase reductase Sdr
K3X41_RS08775	COG4964	Belongs to the GSP D family
K3X41_RS08830	COG1201	RNA secondary structure unwinding
K3X41_RS08845	COG1024	Enoyl-CoA hydratase
K3X41_RS08855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K3X41_RS08860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K3X41_RS08865	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K3X41_RS08870	COG3239	Fatty acid desaturase
K3X41_RS08880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K3X41_RS08885	COG0037	tRNA processing
K3X41_RS08895	COG2885	chlorophyll binding
K3X41_RS08925	COG0824	Thioesterase
K3X41_RS08945	COG2255	four-way junction helicase activity
K3X41_RS08950	COG0632	four-way junction helicase activity
K3X41_RS08960	COG1053	succinate dehydrogenase
K3X41_RS08970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K3X41_RS08985	COG0330	HflC and HflK could
K3X41_RS08990	COG0330	HflC and HflK could
K3X41_RS09000	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K3X41_RS09005	COG2832	Protein of unknown function (DUF454)
K3X41_RS09010	COG1760	l-serine dehydratase
K3X41_RS09035	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K3X41_RS09045	COG0504	CTP synthase activity
K3X41_RS09075	COG4215	(ABC) transporter
K3X41_RS09085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3X41_RS09085	COG0519	Catalyzes the synthesis of GMP from XMP
K3X41_RS09090	COG0174	glutamine synthetase
K3X41_RS09095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K3X41_RS09100	COG0583	DNA-binding transcription factor activity
K3X41_RS09105	COG0658	competence protein
K3X41_RS09105	COG2333	competence protein COMEC
K3X41_RS09110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3X41_RS09120	COG1024	Enoyl-CoA hydratase
K3X41_RS09125	COG3088	subunit of a heme lyase
K3X41_RS09130	COG1138	Cytochrome C-type biogenesis protein
K3X41_RS09160	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K3X41_RS09165	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K3X41_RS09170	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K3X41_RS09185	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K3X41_RS09190	COG1357	PFAM Pentapeptide repeats (8 copies)
K3X41_RS09200	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K3X41_RS09215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K3X41_RS09220	COG0697	spore germination
K3X41_RS09225	COG2354	Protein conserved in bacteria
K3X41_RS09255	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K3X41_RS09285	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
K3X41_RS09290	COG1960	acyl-CoA dehydrogenase activity
K3X41_RS09295	COG1024	Enoyl-CoA hydratase
K3X41_RS09315	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X41_RS09320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3X41_RS09325	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3X41_RS09340	COG4191	Histidine kinase
K3X41_RS09350	COG1522	sequence-specific DNA binding
K3X41_RS09360	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K3X41_RS09365	COG0175	sulfate reduction
K3X41_RS09380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K3X41_RS09395	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K3X41_RS09395	COG3608	succinylglutamate desuccinylase aspartoacylase
K3X41_RS09445	COG0418	dihydroorotase activity
K3X41_RS09450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K3X41_RS09455	COG0305	Participates in initiation and elongation during chromosome replication
K3X41_RS09475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K3X41_RS09485	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K3X41_RS09500	COG0300	oxidoreductase activity
K3X41_RS09505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3X41_RS09515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K3X41_RS09520	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K3X41_RS09525	COG4133	protoheme IX ABC transporter activity
K3X41_RS09530	COG3737	Protein of unknown function (DUF498/DUF598)
K3X41_RS09540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K3X41_RS09545	COG1862	Preprotein translocase
K3X41_RS09555	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K3X41_RS09565	COG0805	protein transport
K3X41_RS09575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K3X41_RS09585	COG3842	ATPase activity
K3X41_RS09595	COG0443	Heat shock 70 kDa protein
K3X41_RS09600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3X41_RS09615	COG1028	Short-chain dehydrogenase reductase Sdr
K3X41_RS09645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K3X41_RS09660	COG0659	secondary active sulfate transmembrane transporter activity
K3X41_RS09665	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K3X41_RS09670	COG2311	Membrane
K3X41_RS09675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K3X41_RS09690	COG0612	Peptidase, M16
K3X41_RS09710	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K3X41_RS09720	COG0109	protoheme IX farnesyltransferase activity
K3X41_RS09730	COG0312	modulator of DNA gyrase
K3X41_RS09745	COG0758	DNA mediated transformation
K3X41_RS09750	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K3X41_RS09780	COG0131	Imidazoleglycerol-phosphate dehydratase
K3X41_RS09790	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K3X41_RS09800	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K3X41_RS09810	COG0107	imidazoleglycerol-phosphate synthase activity
K3X41_RS09815	COG0140	phosphoribosyl-ATP diphosphatase activity
K3X41_RS09830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K3X41_RS09845	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3X41_RS09845	COG1618	nucleotide phosphatase activity, acting on free nucleotides
K3X41_RS09850	COG3005	denitrification pathway
K3X41_RS09860	COG0348	domain, Protein
K3X41_RS09865	COG0437	4 iron, 4 sulfur cluster binding
K3X41_RS09870	COG0243	molybdopterin cofactor binding
K3X41_RS09880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K3X41_RS09880	COG2221	Nitrite and sulphite reductase 4Fe-4S
K3X41_RS09980	COG0582	viral genome integration into host DNA
K3X41_RS09990	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K3X41_RS09995	COG1530	ribonuclease E activity
K3X41_RS10005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K3X41_RS10030	COG5328	Belongs to the UPF0262 family
K3X41_RS10035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K3X41_RS10045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K3X41_RS10065	COG3916	Acyl-homoserine-lactone synthase
K3X41_RS10075	COG0318	PFAM AMP-dependent synthetase and ligase
K3X41_RS10080	COG1132	(ABC) transporter
K3X41_RS10085	COG0116	Belongs to the methyltransferase superfamily
K3X41_RS10085	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K3X41_RS10095	COG2188	Transcriptional regulator
K3X41_RS10105	COG2267	carboxylic ester hydrolase activity
K3X41_RS10115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K3X41_RS10120	COG1012	belongs to the aldehyde dehydrogenase family
K3X41_RS10140	COG0826	peptidase U32
K3X41_RS10150	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K3X41_RS10190	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K3X41_RS10200	COG1805	sodium ion transport
K3X41_RS10205	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K3X41_RS10210	COG1477	protein flavinylation
K3X41_RS10235	COG0321	lipoyl(octanoyl) transferase activity
K3X41_RS10240	COG3474	cytochrome
K3X41_RS10260	COG0505	Belongs to the CarA family
K3X41_RS10270	COG1802	Transcriptional regulator
K3X41_RS10305	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K3X41_RS10315	COG0697	spore germination
K3X41_RS10320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K3X41_RS10340	COG0574	Belongs to the PEP-utilizing enzyme family
K3X41_RS10340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K3X41_RS10345	COG0751	glycine-tRNA ligase activity
K3X41_RS10355	COG0752	glycyl-tRNA synthetase alpha subunit
K3X41_RS10370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K3X41_RS10380	COG1469	GTP cyclohydrolase I activity
K3X41_RS10390	COG2917	probably involved in intracellular septation
K3X41_RS10400	COG0552	protein localization to endoplasmic reticulum
K3X41_RS10430	COG3853	Toxic anion resistance protein (TelA)
K3X41_RS10455	COG1490	D-aminoacyl-tRNA deacylase activity
K3X41_RS10465	COG0287	Prephenate dehydrogenase
K3X41_RS10470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K3X41_RS10480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K3X41_RS10500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K3X41_RS10530	COG2197	response regulator
K3X41_RS10545	COG0444	Belongs to the ABC transporter superfamily
K3X41_RS10550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X41_RS10555	COG0601	transmembrane transport
K3X41_RS10600	COG0559	Belongs to the binding-protein-dependent transport system permease family
K3X41_RS10635	COG0471	metal ion transport
K3X41_RS10635	COG3273	potassium ion transport
K3X41_RS10645	COG1692	metallophosphoesterase
K3X41_RS10650	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K3X41_RS10665	COG1744	ABC transporter substrate-binding protein PnrA-like
K3X41_RS10670	COG3845	ABC transporter
K3X41_RS10675	COG4603	Belongs to the binding-protein-dependent transport system permease family
K3X41_RS10680	COG1079	Belongs to the binding-protein-dependent transport system permease family
K3X41_RS10700	COG1028	Short-chain dehydrogenase reductase Sdr
K3X41_RS10725	COG0604	alcohol dehydrogenase
K3X41_RS10730	COG2937	Belongs to the GPAT DAPAT family
K3X41_RS10735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X41_RS10735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X41_RS10745	COG0813	purine-nucleoside phosphorylase activity
K3X41_RS10760	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3X41_RS10760	COG1618	nucleotide phosphatase activity, acting on free nucleotides
K3X41_RS10775	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X41_RS10780	COG1012	belongs to the aldehyde dehydrogenase family
K3X41_RS10785	COG1960	acyl-CoA dehydrogenase activity
K3X41_RS10790	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3X41_RS10795	COG3800	Transcriptional regulator
K3X41_RS10795	COG1396	sequence-specific DNA binding
K3X41_RS10800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3X41_RS10820	COG0625	glutathione transferase activity
K3X41_RS10895	COG2353	YceI-like domain
K3X41_RS10905	COG0012	GTP binding
K3X41_RS10915	COG0159	tryptophan synthase activity
K3X41_RS10930	COG0513	Belongs to the DEAD box helicase family
K3X41_RS10955	COG0193	aminoacyl-tRNA hydrolase activity
K3X41_RS10970	COG0133	tryptophan synthase activity
K3X41_RS10975	COG0135	phosphoribosylanthranilate isomerase activity
K3X41_RS10985	COG0776	regulation of translation
K3X41_RS10990	COG0539	negative regulation of cytoplasmic translation
K3X41_RS11000	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K3X41_RS11020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K3X41_RS11025	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K3X41_RS11030	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K3X41_RS11035	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K3X41_RS11040	COG1253	flavin adenine dinucleotide binding
K3X41_RS11045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K3X41_RS11050	COG1702	phosphate starvation-inducible protein PhoH
K3X41_RS11065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3X41_RS11075	COG1047	Peptidyl-prolyl cis-trans
K3X41_RS11085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K3X41_RS11090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K3X41_RS11095	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K3X41_RS11115	COG2267	carboxylic ester hydrolase activity
K3X41_RS11125	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K3X41_RS11135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3X41_RS11160	COG2824	Alkylphosphonate utilization operon protein PhnA
K3X41_RS11175	COG0481	GTPase activity
K3X41_RS11205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K3X41_RS11215	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K3X41_RS11230	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K3X41_RS11240	COG1132	(ABC) transporter
K3X41_RS11245	COG1703	isobutyryl-CoA mutase activity
K3X41_RS11250	COG1643	Atp-dependent helicase
K3X41_RS11260	COG0306	phosphate transporter
K3X41_RS11270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K3X41_RS11275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K3X41_RS11295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3X41_RS11315	COG0512	Glutamine amidotransferase of anthranilate synthase
K3X41_RS11315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K3X41_RS11325	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K3X41_RS11340	COG0346	lactoylglutathione lyase activity
K3X41_RS11360	COG0778	Nitroreductase
K3X41_RS11370	COG1872	DUF167
K3X41_RS11375	COG3152	Membrane
K3X41_RS11380	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K3X41_RS11410	COG0540	Belongs to the ATCase OTCase family
K3X41_RS11425	COG1573	uracil-dna glycosylase
K3X41_RS11430	COG0521	Mo-molybdopterin cofactor biosynthetic process
K3X41_RS11440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3X41_RS11450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K3X41_RS11470	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K3X41_RS11475	COG0142	geranyltranstransferase activity
K3X41_RS11500	COG0583	DNA-binding transcription factor activity
K3X41_RS11505	COG1028	Short-chain dehydrogenase reductase Sdr
K3X41_RS11520	COG2818	Glycosylase
K3X41_RS11525	COG2951	lytic endotransglycosylase activity
K3X41_RS11540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3X41_RS11545	COG0165	Argininosuccinate lyase
K3X41_RS11550	COG0019	diaminopimelate decarboxylase activity
K3X41_RS11560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K3X41_RS11585	COG1162	GTPase activity
K3X41_RS11595	COG0737	Belongs to the 5'-nucleotidase family
K3X41_RS11600	COG2816	NAD+ diphosphatase activity
K3X41_RS11615	COG3474	cytochrome
K3X41_RS11620	COG4166	transmembrane transport
K3X41_RS11625	COG4174	ABC transporter (Permease)
K3X41_RS11630	COG4239	(ABC) transporter, permease
K3X41_RS11635	COG4172	Belongs to the ABC transporter superfamily
K3X41_RS11640	COG1686	Belongs to the peptidase S11 family
K3X41_RS11645	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K3X41_RS11650	COG2813	Specifically methylates the guanine in position
K3X41_RS11660	COG0408	coproporphyrinogen oxidase activity
K3X41_RS11670	COG1846	Transcriptional regulator
K3X41_RS11675	COG0183	Belongs to the thiolase family
K3X41_RS11680	COG0181	hydroxymethylbilane synthase activity
K3X41_RS11685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K3X41_RS11695	COG0513	Belongs to the DEAD box helicase family
K3X41_RS11700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K3X41_RS11715	COG0288	reversible hydration of carbon dioxide
K3X41_RS11725	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K3X41_RS11730	COG0791	NLP P60 protein
K3X41_RS11740	COG2050	protein possibly involved in aromatic compounds catabolism
K3X41_RS11765	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K3X41_RS11780	COG0679	Auxin Efflux Carrier
K3X41_RS11790	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K3X41_RS11795	COG1671	Belongs to the UPF0178 family
K3X41_RS11805	COG1280	lysine exporter protein (LysE YggA)
K3X41_RS11810	COG2897	thiosulfate sulfurtransferase activity
K3X41_RS11825	COG0004	ammonium transporteR
K3X41_RS11830	COG0347	Belongs to the P(II) protein family
K3X41_RS11860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K3X41_RS11870	COG0584	glycerophosphoryl diester phosphodiesterase
K3X41_RS11880	COG2154	pterin-4-alpha-carbinolamine dehydratase
K3X41_RS11890	COG0742	ribosomal rna small subunit methyltransferase
K3X41_RS11895	COG0024	Methionine aminopeptidase
K3X41_RS11900	COG1489	DNA binding
K3X41_RS11905	COG1058	Belongs to the CinA family
K3X41_RS11905	COG1546	Belongs to the CinA family
K3X41_RS11925	COG0583	DNA-binding transcription factor activity
K3X41_RS11935	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X41_RS11935	COG1902	pentaerythritol trinitrate reductase activity
K3X41_RS11960	COG1266	CAAX protease self-immunity
K3X41_RS11965	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K3X41_RS11970	COG0285	dihydrofolate synthase activity
K3X41_RS11985	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K3X41_RS12000	COG0686	Belongs to the AlaDH PNT family
K3X41_RS12010	COG0668	transmembrane transport
K3X41_RS12015	COG1970	mechanosensitive ion channel activity
K3X41_RS12025	COG0072	phenylalanine-tRNA ligase activity
K3X41_RS12025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3X41_RS12045	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K3X41_RS12050	COG1595	DNA-templated transcription, initiation
K3X41_RS12055	COG3795	YCII-related domain
K3X41_RS12065	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K3X41_RS12070	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K3X41_RS12080	COG0469	pyruvate kinase activity
K3X41_RS12105	COG3384	dioxygenase
K3X41_RS12120	COG4948	Mandelate Racemase Muconate Lactonizing
K3X41_RS12150	COG0825	malonyl-CoA metabolic process
K3X41_RS12170	COG2884	Cell division ATP-binding protein ftsE
K3X41_RS12205	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
K3X41_RS12215	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K3X41_RS12225	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K3X41_RS12240	COG0284	orotidine-5'-phosphate decarboxylase activity
K3X41_RS12260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K3X41_RS12275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K3X41_RS12290	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K3X41_RS12310	COG0559	Belongs to the binding-protein-dependent transport system permease family
K3X41_RS12340	COG3383	formate dehydrogenase (NAD+) activity
K3X41_RS12385	COG0612	Peptidase, M16
K3X41_RS12390	COG0612	Peptidase, M16
K3X41_RS12400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K3X41_RS12405	COG0138	bifunctional purine biosynthesis protein purh
K3X41_RS12415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K3X41_RS12415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K3X41_RS12425	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K3X41_RS12430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K3X41_RS12435	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K3X41_RS12440	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K3X41_RS12460	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K3X41_RS12470	COG1185	polyribonucleotide nucleotidyltransferase activity
K3X41_RS12490	COG1733	regulation of RNA biosynthetic process
K3X41_RS12500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K3X41_RS12505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K3X41_RS12515	COG0560	Phosphoserine phosphatase
K3X41_RS12540	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K3X41_RS12570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3X41_RS12575	COG2171	N-acyltransferase activity
K3X41_RS12615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K3X41_RS12620	COG0557	exoribonuclease II activity
K3X41_RS12625	COG2951	lytic endotransglycosylase activity
K3X41_RS12645	COG1051	belongs to the nudix hydrolase family
K3X41_RS12650	COG0793	Belongs to the peptidase S41A family
K3X41_RS12660	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K3X41_RS12670	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K3X41_RS12675	COG0799	negative regulation of ribosome biogenesis
K3X41_RS12685	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3X41_RS12685	COG3264	Mechanosensitive ion channel
K3X41_RS12690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K3X41_RS12695	COG0066	3-isopropylmalate dehydratase activity
K3X41_RS12710	COG0473	3-isopropylmalate dehydrogenase activity
K3X41_RS12730	COG1960	acyl-CoA dehydrogenase activity
K3X41_RS12735	COG2329	Antibiotic biosynthesis monooxygenase
K3X41_RS12745	COG2233	PERMEase
K3X41_RS12750	COG0277	FAD linked oxidase domain protein
K3X41_RS12765	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3X41_RS12770	COG2186	Transcriptional regulator
K3X41_RS12775	COG0560	Phosphoserine phosphatase
K3X41_RS12785	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K3X41_RS12790	COG0765	amino acid transport
K3X41_RS12795	COG1126	abc transporter atp-binding protein
K3X41_RS12800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3X41_RS12810	COG4608	Belongs to the ABC transporter superfamily
K3X41_RS12815	COG0444	Belongs to the ABC transporter superfamily
K3X41_RS12820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X41_RS12825	COG0601	transmembrane transport
K3X41_RS12830	COG0747	negative chemotaxis
K3X41_RS12835	COG1802	Transcriptional regulator
K3X41_RS12860	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K3X41_RS12865	COG4172	Belongs to the ABC transporter superfamily
K3X41_RS12875	COG0601	transmembrane transport
K3X41_RS12885	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X41_RS12895	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3X41_RS12915	COG0798	PFAM Bile acid sodium symporter
K3X41_RS12920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K3X41_RS12930	COG1349	DNA-binding transcription factor activity
K3X41_RS12945	COG2010	Cytochrome c
K3X41_RS12965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K3X41_RS12970	COG2010	Cytochrome c
K3X41_RS12975	COG3391	amine dehydrogenase activity
K3X41_RS12980	COG1522	sequence-specific DNA binding
K3X41_RS12995	COG0535	radical SAM domain protein
K3X41_RS13010	COG2197	response regulator
K3X41_RS13020	COG1024	Enoyl-CoA hydratase
K3X41_RS13050	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K3X41_RS13065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K3X41_RS13085	COG1766	The M ring may be actively involved in energy transduction
K3X41_RS13095	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K3X41_RS13100	COG1338	Plays a role in the flagellum-specific transport system
K3X41_RS13105	COG4948	Mandelate Racemase Muconate Lactonizing
K3X41_RS13115	COG0583	DNA-binding transcription factor activity
K3X41_RS13120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X41_RS13125	COG0563	adenylate kinase activity
K3X41_RS13135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K3X41_RS13140	COG0517	IMP dehydrogenase activity
K3X41_RS13140	COG0617	tRNA 3'-terminal CCA addition
K3X41_RS13140	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K3X41_RS13150	COG2176	DNA-directed DNA polymerase activity
K3X41_RS13150	COG5002	protein histidine kinase activity
K3X41_RS13155	COG0243	molybdopterin cofactor binding
K3X41_RS13245	COG0183	Belongs to the thiolase family
K3X41_RS13285	COG1674	ftsk spoiiie
K3X41_RS13305	COG0154	amidase activity
K3X41_RS13310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K3X41_RS13320	COG2835	tetraacyldisaccharide 4'-kinase activity
K3X41_RS13335	COG0708	Exodeoxyribonuclease III
K3X41_RS13345	COG0789	Transcriptional regulator
K3X41_RS13355	COG0456	acetyltransferase
K3X41_RS13360	COG0745	RESPONSE REGULATOR receiver
K3X41_RS13375	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K3X41_RS13395	COG0495	leucyl-tRNA aminoacylation
K3X41_RS13410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X41_RS13410	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K3X41_RS13415	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3X41_RS13415	COG3264	Mechanosensitive ion channel
K3X41_RS13420	COG1024	Enoyl-CoA hydratase
K3X41_RS13425	COG4221	oxidoreductase activity
K3X41_RS13430	COG0312	modulator of DNA gyrase
K3X41_RS13435	COG0483	inositol monophosphate 1-phosphatase activity
K3X41_RS13440	COG1609	Transcriptional regulator
K3X41_RS13470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K3X41_RS13475	COG0297	glycogen (starch) synthase activity
K3X41_RS13485	COG0438	transferase activity, transferring glycosyl groups
K3X41_RS13510	COG0438	transferase activity, transferring glycosyl groups
K3X41_RS13540	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X41_RS13560	COG0662	Cupin 2, conserved barrel domain protein
K3X41_RS13560	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K3X41_RS13580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K3X41_RS13600	COG1194	a g-specific adenine glycosylase
K3X41_RS13610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K3X41_RS13615	COG3034	peptidoglycan biosynthetic process
K3X41_RS13620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K3X41_RS13625	COG0617	tRNA 3'-terminal CCA addition
K3X41_RS13630	COG0494	nUDIX hydrolase
K3X41_RS13640	COG0745	RESPONSE REGULATOR receiver
K3X41_RS13650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3X41_RS13660	COG0137	argininosuccinate synthase activity
K3X41_RS13675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3X41_RS13680	COG0473	3-isopropylmalate dehydrogenase activity
K3X41_RS13695	COG0435	Glutathione S-transferase
K3X41_RS13700	COG0281	malic enzyme
K3X41_RS13700	COG0280	phosphate acetyltransferase
K3X41_RS13705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K3X41_RS13710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K3X41_RS13715	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
K3X41_RS13720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K3X41_RS13725	COG1420	regulation of RNA biosynthetic process
K3X41_RS13730	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K3X41_RS13735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K3X41_RS13740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3X41_RS13755	COG0357	Ribosomal RNA small subunit methyltransferase G
K3X41_RS13760	COG0445	tRNA wobble uridine modification
K3X41_RS13765	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K3X41_RS13770	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K3X41_RS13775	COG1981	membrane
K3X41_RS13780	COG0424	maF-like protein
K3X41_RS13785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K3X41_RS13790	COG0237	dephospho-CoA kinase activity
K3X41_RS13795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K3X41_RS13805	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K3X41_RS13810	COG3030	protein affecting phage T7 exclusion by the F plasmid
K3X41_RS13835	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K3X41_RS13840	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K3X41_RS13855	COG1040	competence protein
K3X41_RS13865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K3X41_RS13880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K3X41_RS13900	COG0779	Required for maturation of 30S ribosomal subunits
K3X41_RS13915	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K3X41_RS13925	COG0494	nUDIX hydrolase
K3X41_RS13930	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K3X41_RS13935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K3X41_RS13940	COG0653	protein targeting
K3X41_RS13950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K3X41_RS13955	COG2003	Belongs to the UPF0758 family
K3X41_RS13960	COG0484	heat shock protein binding
K3X41_RS13965	COG0443	Heat shock 70 kDa protein
K3X41_RS13985	COG1218	3'(2'),5'-bisphosphate nucleotidase
K3X41_RS13990	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K3X41_RS14020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K3X41_RS14025	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K3X41_RS14030	COG1137	ATPase activity
K3X41_RS14050	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3X41_RS14060	COG0437	4 iron, 4 sulfur cluster binding
K3X41_RS14065	COG0243	molybdopterin cofactor binding
K3X41_RS14070	COG0657	acetylesterase activity
K3X41_RS14080	COG1663	tetraacyldisaccharide 4'-kinase activity
K3X41_RS14105	COG0714	Associated with various cellular activities
K3X41_RS14115	COG1845	cytochrome c oxidase, subunit III
K3X41_RS14125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3X41_RS14140	COG2226	methyltransferase
K3X41_RS14155	COG4263	nitrous-oxide reductase activity
K3X41_RS14180	COG0437	4 iron, 4 sulfur cluster binding
K3X41_RS14185	COG0348	domain, Protein
K3X41_RS14210	COG1999	signal sequence binding
K3X41_RS14235	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K3X41_RS14240	COG3178	'Phosphotransferase
K3X41_RS14245	COG0802	atpase or kinase
K3X41_RS14260	COG1999	signal sequence binding
K3X41_RS14265	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K3X41_RS14285	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K3X41_RS14295	COG1442	glycosyl transferase family 8
K3X41_RS14295	COG1216	Glycosyl transferase, family 2
K3X41_RS14305	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K3X41_RS14310	COG0133	tryptophan synthase activity
K3X41_RS14315	COG1652	LysM domain
K3X41_RS14345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K3X41_RS14350	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K3X41_RS14375	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K3X41_RS14415	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K3X41_RS14445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X41_RS14465	COG5598	trimethylamine methyltransferase
K3X41_RS14470	COG1902	pentaerythritol trinitrate reductase activity
K3X41_RS14470	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X41_RS14475	COG1902	pentaerythritol trinitrate reductase activity
K3X41_RS14475	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X41_RS14480	COG0129	dihydroxy-acid dehydratase activity
K3X41_RS14490	COG2175	clavaminate synthase activity
K3X41_RS14510	COG3243	poly(R)-hydroxyalkanoic acid synthase
K3X41_RS14525	COG1228	amidohydrolase
K3X41_RS14530	COG2986	histidine ammonia-lyase
K3X41_RS14540	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K3X41_RS14545	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3X41_RS14555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X41_RS14570	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K3X41_RS14575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3X41_RS14580	COG2808	Putative FMN-binding domain
K3X41_RS14625	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K3X41_RS14640	COG1028	Short-chain dehydrogenase reductase Sdr
K3X41_RS14645	COG0697	spore germination
K3X41_RS14650	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K3X41_RS14655	COG1418	mRNA catabolic process
K3X41_RS14675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K3X41_RS14680	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K3X41_RS14690	COG1960	acyl-CoA dehydrogenase activity
K3X41_RS14715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K3X41_RS14720	COG0142	geranyltranstransferase activity
K3X41_RS14725	COG1722	exodeoxyribonuclease VII activity
K3X41_RS14730	COG0123	including yeast histone deacetylase and acetoin utilization protein
K3X41_RS14740	COG0745	RESPONSE REGULATOR receiver
K3X41_RS14745	COG1846	Transcriptional regulator
K3X41_RS14750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K3X41_RS14770	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K3X41_RS14780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K3X41_RS14800	COG1968	undecaprenyl-diphosphatase activity
K3X41_RS14815	COG0564	pseudouridine synthase activity
K3X41_RS14860	COG0179	Fumarylacetoacetate (FAA) hydrolase
K3X41_RS14865	COG0625	glutathione transferase activity
K3X41_RS14870	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K3X41_RS14875	COG1360	Flagellar Motor Protein
K3X41_RS14880	COG4786	Flagellar basal body rod
K3X41_RS14895	COG1706	bacterial-type flagellum-dependent cell motility
K3X41_RS14905	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K3X41_RS14915	COG4786	Flagellar basal body rod
K3X41_RS14920	COG4786	Flagellar basal body rod
K3X41_RS14925	COG1987	bacterial-type flagellum assembly
K3X41_RS14930	COG1677	Flagellar hook-basal body complex protein FliE
K3X41_RS14935	COG1558	bacterial-type flagellum-dependent cell motility
K3X41_RS14985	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K3X41_RS14995	COG2226	methyltransferase
K3X41_RS15005	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K3X41_RS15010	COG1024	Enoyl-CoA hydratase
K3X41_RS15015	COG0268	Binds directly to 16S ribosomal RNA
K3X41_RS15025	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K3X41_RS15030	COG1459	type II secretion system
K3X41_RS15035	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K3X41_RS15060	COG1450	Type ii and iii secretion system protein
K3X41_RS15115	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K3X41_RS15155	COG1215	transferase activity, transferring glycosyl groups
K3X41_RS15170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K3X41_RS15180	COG0698	ribose 5-phosphate isomerase
K3X41_RS15190	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K3X41_RS15200	COG0729	surface antigen
K3X41_RS15215	COG0010	Belongs to the arginase family
K3X41_RS15225	COG2183	response to ionizing radiation
K3X41_RS15235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K3X41_RS15255	COG3842	ATPase activity
K3X41_RS15270	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3X41_RS15275	COG4149	molybdate abc transporter
K3X41_RS15280	COG0725	ABC transporter, periplasmic molybdate-binding protein
K3X41_RS15305	COG1115	amino acid carrier protein
K3X41_RS15315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X41_RS15320	COG0509	glycine decarboxylation via glycine cleavage system
K3X41_RS15325	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K3X41_RS15325	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K3X41_RS15340	COG1192	Involved in chromosome partitioning
K3X41_RS15350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K3X41_RS15355	COG4134	Bacterial extracellular solute-binding protein
K3X41_RS15360	COG4135	transport system, permease component
K3X41_RS15365	COG4136	ATPase activity
K3X41_RS15370	COG1122	ATPase activity
K3X41_RS15375	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K3X41_RS15380	COG1268	BioY protein
K3X41_RS15385	COG2351	hydroxyisourate hydrolase activity
K3X41_RS15390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K3X41_RS15415	COG1473	amidohydrolase
K3X41_RS15420	COG1522	sequence-specific DNA binding
K3X41_RS15425	COG2226	methyltransferase
K3X41_RS15435	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K3X41_RS15435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X41_RS15440	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K3X41_RS15445	COG0156	8-amino-7-oxononanoate synthase activity
K3X41_RS15450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K3X41_RS15460	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
K3X41_RS15460	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
K3X41_RS15460	COG0506	proline dehydrogenase activity
K3X41_RS15465	COG1522	sequence-specific DNA binding
K3X41_RS15470	COG1049	propionate catabolic process, 2-methylcitrate cycle
K3X41_RS15480	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K3X41_RS15490	COG0688	phosphatidylethanolamine metabolic process
K3X41_RS15495	COG1183	phosphatidylcholine synthase activity
K3X41_RS15505	COG0310	cobalt ion transport
K3X41_RS15510	COG0310	cobalt ion transport
K3X41_RS15520	COG1122	ATPase activity
K3X41_RS15530	COG0174	glutamine synthetase
K3X41_RS15535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X41_RS15540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X41_RS15545	COG3800	Transcriptional regulator
K3X41_RS15545	COG1396	sequence-specific DNA binding
K3X41_RS15550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3X41_RS15555	COG1960	acyl-CoA dehydrogenase activity
K3X41_RS15560	COG1012	belongs to the aldehyde dehydrogenase family
K3X41_RS15565	COG4566	intracellular signal transduction
K3X41_RS15575	COG2358	TRAP transporter, solute receptor (TAXI family
K3X41_RS15615	COG0395	ABC-type sugar transport system, permease component
K3X41_RS15620	COG1175	transmembrane transport
K3X41_RS15625	COG3842	ATPase activity
K3X41_RS15630	COG3842	ATPase activity
K3X41_RS15690	COG0134	indole-3-glycerol-phosphate synthase activity
K3X41_RS15695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K3X41_RS15700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3X41_RS15705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K3X41_RS15710	COG1960	acyl-CoA dehydrogenase activity
K3X41_RS15725	COG0662	Cupin 2, conserved barrel domain protein
K3X41_RS15735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3X41_RS15735	COG4191	Histidine kinase
K3X41_RS15750	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K3X41_RS15760	COG1136	(ABC) transporter
K3X41_RS15770	COG0745	RESPONSE REGULATOR receiver
K3X41_RS15775	COG0163	prenyltransferase activity
K3X41_RS15780	COG1280	lysine exporter protein (LysE YggA)