locus-tag	class	description
K3556_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K3556_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K3556_RS00025	COG1280	lysine exporter protein (LysE YggA)
K3556_RS00055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K3556_RS00060	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K3556_RS00065	COG2350	Protein conserved in bacteria
K3556_RS00085	COG1652	LysM domain
K3556_RS00090	COG0133	tryptophan synthase activity
K3556_RS00100	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K3556_RS00105	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K3556_RS00120	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K3556_RS00125	COG1999	signal sequence binding
K3556_RS00135	COG2205	protein histidine kinase activity
K3556_RS00140	COG0802	atpase or kinase
K3556_RS00145	COG3178	'Phosphotransferase
K3556_RS00150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K3556_RS00160	COG1074	ATP-dependent DNA helicase activity
K3556_RS00180	COG3034	peptidoglycan biosynthetic process
K3556_RS00185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K3556_RS00190	COG0617	tRNA 3'-terminal CCA addition
K3556_RS00195	COG0494	nUDIX hydrolase
K3556_RS00205	COG0494	nUDIX hydrolase
K3556_RS00210	COG0745	RESPONSE REGULATOR receiver
K3556_RS00220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3556_RS00230	COG0137	argininosuccinate synthase activity
K3556_RS00245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3556_RS00250	COG0473	3-isopropylmalate dehydrogenase activity
K3556_RS00265	COG0280	phosphate acetyltransferase
K3556_RS00265	COG0281	malic enzyme
K3556_RS00270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K3556_RS00275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K3556_RS00280	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K3556_RS00285	COG1420	regulation of RNA biosynthetic process
K3556_RS00290	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K3556_RS00295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K3556_RS00300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3556_RS00315	COG0357	Ribosomal RNA small subunit methyltransferase G
K3556_RS00320	COG0445	tRNA wobble uridine modification
K3556_RS00325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K3556_RS00330	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K3556_RS00335	COG1981	membrane
K3556_RS00340	COG0424	maF-like protein
K3556_RS00345	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K3556_RS00350	COG0237	dephospho-CoA kinase activity
K3556_RS00355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K3556_RS00360	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K3556_RS00365	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K3556_RS00395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K3556_RS00400	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K3556_RS00425	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K3556_RS00430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K3556_RS00445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K3556_RS00455	COG0779	Required for maturation of 30S ribosomal subunits
K3556_RS00470	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K3556_RS00480	COG0494	nUDIX hydrolase
K3556_RS00485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K3556_RS00490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K3556_RS00495	COG0653	protein targeting
K3556_RS00505	COG2003	Belongs to the UPF0758 family
K3556_RS00515	COG0443	Heat shock 70 kDa protein
K3556_RS00530	COG1218	3'(2'),5'-bisphosphate nucleotidase
K3556_RS00535	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K3556_RS00565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K3556_RS00570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K3556_RS00575	COG1137	ATPase activity
K3556_RS00600	COG0437	4 iron, 4 sulfur cluster binding
K3556_RS00605	COG0243	molybdopterin cofactor binding
K3556_RS00620	COG1663	tetraacyldisaccharide 4'-kinase activity
K3556_RS00625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K3556_RS00655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K3556_RS00675	COG3257	ureidoglycine aminohydrolase activity
K3556_RS00680	COG1414	Transcriptional regulator
K3556_RS00685	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K3556_RS00690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3556_RS00695	COG3616	Alanine racemase, N-terminal domain
K3556_RS00700	COG2423	ornithine cyclodeaminase activity
K3556_RS00705	COG0281	malic enzyme
K3556_RS00705	COG0280	phosphate acetyltransferase
K3556_RS00715	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
K3556_RS00725	COG2351	hydroxyisourate hydrolase activity
K3556_RS00730	COG0583	DNA-binding transcription factor activity
K3556_RS00745	COG0583	DNA-binding transcription factor activity
K3556_RS00770	COG0402	S-adenosylhomocysteine deaminase activity
K3556_RS00780	COG1609	Transcriptional regulator
K3556_RS00790	COG0312	modulator of DNA gyrase
K3556_RS00800	COG1024	Enoyl-CoA hydratase
K3556_RS00805	COG3264	Mechanosensitive ion channel
K3556_RS00805	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3556_RS00815	COG0625	glutathione transferase activity
K3556_RS00830	COG0495	leucyl-tRNA aminoacylation
K3556_RS00845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K3556_RS00860	COG0745	RESPONSE REGULATOR receiver
K3556_RS00875	COG0789	Transcriptional regulator
K3556_RS00885	COG0708	Exodeoxyribonuclease III
K3556_RS00900	COG2835	tetraacyldisaccharide 4'-kinase activity
K3556_RS00905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K3556_RS00915	COG0436	Aminotransferase
K3556_RS00920	COG1674	ftsk spoiiie
K3556_RS00955	COG1366	Belongs to the anti-sigma-factor antagonist family
K3556_RS00960	COG0183	Belongs to the thiolase family
K3556_RS00965	COG1956	GAF domain-containing protein
K3556_RS01005	COG0564	pseudouridine synthase activity
K3556_RS01025	COG0450	alkyl hydroperoxide reductase
K3556_RS01050	COG0179	Fumarylacetoacetate (FAA) hydrolase
K3556_RS01055	COG0625	glutathione transferase activity
K3556_RS01060	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K3556_RS01085	COG1706	bacterial-type flagellum-dependent cell motility
K3556_RS01105	COG1840	ABC-type Fe3 transport system, periplasmic component
K3556_RS01110	COG3842	ATPase activity
K3556_RS01125	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K3556_RS01135	COG1012	belongs to the aldehyde dehydrogenase family
K3556_RS01150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K3556_RS01180	COG4176	ABC-type proline glycine betaine transport system permease component
K3556_RS01185	COG3448	diguanylate cyclase activity
K3556_RS01185	COG4175	Glycine betaine
K3556_RS01195	COG1349	DNA-binding transcription factor activity
K3556_RS01200	COG1522	sequence-specific DNA binding
K3556_RS01205	COG1473	amidohydrolase
K3556_RS01210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3556_RS01265	COG0280	phosphate acetyltransferase
K3556_RS01275	COG4584	PFAM Integrase catalytic
K3556_RS01280	COG1484	DNA-dependent DNA replication
K3556_RS01315	COG1414	Transcriptional regulator
K3556_RS01325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3556_RS01330	COG1960	acyl-CoA dehydrogenase activity
K3556_RS01335	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3556_RS01345	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K3556_RS01345	COG0662	Cupin 2, conserved barrel domain protein
K3556_RS01355	COG2340	Cysteine-rich secretory protein family
K3556_RS01360	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K3556_RS01370	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K3556_RS01390	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K3556_RS01395	COG1091	dTDP-4-dehydrorhamnose reductase activity
K3556_RS01405	COG0438	transferase activity, transferring glycosyl groups
K3556_RS01405	COG1216	Glycosyl transferase, family 2
K3556_RS01455	COG1054	Belongs to the UPF0176 family
K3556_RS01460	COG1335	isochorismatase
K3556_RS01465	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K3556_RS01490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3556_RS01500	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K3556_RS01510	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
K3556_RS01530	COG0514	ATP-dependent DNA helicase (RecQ)
K3556_RS01560	COG3622	Belongs to the hyi family
K3556_RS01570	COG3718	enzyme involved in inositol metabolism
K3556_RS01585	COG3962	Belongs to the TPP enzyme family
K3556_RS01590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3556_RS01600	COG1172	Belongs to the binding-protein-dependent transport system permease family
K3556_RS01610	COG0673	inositol 2-dehydrogenase activity
K3556_RS01615	COG1609	Transcriptional regulator
K3556_RS01620	COG1028	Short-chain dehydrogenase reductase Sdr
K3556_RS01620	COG3321	synthase
K3556_RS01620	COG0604	alcohol dehydrogenase
K3556_RS01630	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K3556_RS01635	COG2423	ornithine cyclodeaminase activity
K3556_RS01660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K3556_RS01725	COG0028	Belongs to the TPP enzyme family
K3556_RS01740	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K3556_RS01740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3556_RS01750	COG0741	lytic transglycosylase activity
K3556_RS01755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3556_RS01760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K3556_RS01765	COG0303	'Molybdopterin
K3556_RS01770	COG0746	molybdenum cofactor guanylyltransferase activity
K3556_RS01775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K3556_RS01815	COG1960	acyl-CoA dehydrogenase activity
K3556_RS01820	COG0009	L-threonylcarbamoyladenylate synthase
K3556_RS01870	COG0415	Belongs to the DNA photolyase family
K3556_RS01885	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K3556_RS01890	COG0242	peptide deformylase activity
K3556_RS01895	COG0242	peptide deformylase activity
K3556_RS01900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K3556_RS01915	COG0328	RNA-DNA hybrid ribonuclease activity
K3556_RS01925	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K3556_RS01935	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K3556_RS01940	COG1758	RNA polymerase activity
K3556_RS01955	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K3556_RS01960	COG1280	lysine exporter protein (LysE YggA)
K3556_RS01965	COG0736	holo-[acyl-carrier-protein] synthase activity
K3556_RS01970	COG0681	Belongs to the peptidase S26 family
K3556_RS01975	COG0571	ribonuclease III activity
K3556_RS01980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K3556_RS01990	COG1381	Involved in DNA repair and RecF pathway recombination
K3556_RS02015	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K3556_RS02020	COG0745	RESPONSE REGULATOR receiver
K3556_RS02025	COG2205	protein histidine kinase activity
K3556_RS02035	COG1660	Displays ATPase and GTPase activities
K3556_RS02055	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3556_RS02075	COG2096	Adenosyltransferase
K3556_RS02085	COG0300	oxidoreductase activity
K3556_RS02095	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K3556_RS02105	COG0501	Belongs to the peptidase M48B family
K3556_RS02110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K3556_RS02130	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K3556_RS02135	COG0250	Participates in transcription elongation, termination and antitermination
K3556_RS02140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K3556_RS02145	COG0081	regulation of translation
K3556_RS02165	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K3556_RS02170	COG0222	ribosome binding
K3556_RS02175	COG0085	RNA polymerase activity
K3556_RS02180	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K3556_RS02190	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K3556_RS02195	COG0049	tRNA binding
K3556_RS02200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K3556_RS02205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K3556_RS02215	COG0051	transcription antitermination factor activity, RNA binding
K3556_RS02220	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K3556_RS02225	COG0088	Forms part of the polypeptide exit tunnel
K3556_RS02230	COG0089	rRNA binding
K3556_RS02260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K3556_RS02265	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K3556_RS02270	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K3556_RS02275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K3556_RS02280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K3556_RS02310	COG0255	Belongs to the universal ribosomal protein uL29 family
K3556_RS02315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K3556_RS02320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K3556_RS02325	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K3556_RS02330	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K3556_RS02335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K3556_RS02340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K3556_RS02345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K3556_RS02350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K3556_RS02355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K3556_RS02360	COG1841	ribosomal large subunit assembly
K3556_RS02380	COG0200	Binds to the 23S rRNA
K3556_RS02385	COG0201	protein transport
K3556_RS02390	COG0563	adenylate kinase activity
K3556_RS02395	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K3556_RS02400	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K3556_RS02405	COG0202	RNA polymerase activity
K3556_RS02410	COG0203	ribosomal protein L17
K3556_RS02420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K3556_RS02430	COG0564	pseudouridine synthase activity
K3556_RS02435	COG0546	phosphoglycolate phosphatase activity
K3556_RS02445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3556_RS02450	COG4597	amino acid ABC transporter
K3556_RS02455	COG0765	amino acid transport
K3556_RS02460	COG1126	abc transporter atp-binding protein
K3556_RS02485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K3556_RS02490	COG1028	Short-chain dehydrogenase reductase Sdr
K3556_RS02495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K3556_RS02505	COG0706	membrane insertase activity
K3556_RS02515	COG0037	tRNA processing
K3556_RS02530	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K3556_RS02535	COG0594	ribonuclease P activity
K3556_RS02540	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K3556_RS02555	COG5002	protein histidine kinase activity
K3556_RS02565	COG3119	arylsulfatase activity
K3556_RS02575	COG5598	trimethylamine methyltransferase
K3556_RS02580	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3556_RS02580	COG1902	pentaerythritol trinitrate reductase activity
K3556_RS02590	COG2885	chlorophyll binding
K3556_RS02595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K3556_RS02600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K3556_RS02630	COG0277	FAD linked oxidase domain protein
K3556_RS02635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K3556_RS02645	COG1739	Uncharacterized protein family UPF0029
K3556_RS02655	COG1435	thymidine kinase activity
K3556_RS02665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3556_RS02685	COG1136	(ABC) transporter
K3556_RS02705	COG0187	DNA topoisomerase II activity
K3556_RS02715	COG0101	tRNA pseudouridine synthase activity
K3556_RS02720	COG3106	COG3106 Predicted ATPase
K3556_RS02725	COG0456	acetyltransferase
K3556_RS02730	COG3768	UPF0283 membrane protein
K3556_RS02740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K3556_RS02755	COG1131	(ABC) transporter
K3556_RS02760	COG0842	Transport permease protein
K3556_RS02765	COG0616	signal peptide processing
K3556_RS02765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3556_RS02775	COG1028	Short-chain dehydrogenase reductase Sdr
K3556_RS02780	COG0322	excinuclease ABC activity
K3556_RS02785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K3556_RS02795	COG0314	molybdopterin synthase activity
K3556_RS02800	COG1183	phosphatidylcholine synthase activity
K3556_RS02805	COG4974	Belongs to the 'phage' integrase family
K3556_RS02815	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K3556_RS02835	COG2391	methyltransferase activity
K3556_RS02845	COG2264	protein methyltransferase activity
K3556_RS02875	COG1570	exodeoxyribonuclease VII activity
K3556_RS02880	COG1187	pseudouridine synthase activity
K3556_RS02885	COG0590	tRNA wobble adenosine to inosine editing
K3556_RS02890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K3556_RS02895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K3556_RS02900	COG0154	amidase activity
K3556_RS02910	COG3023	N-Acetylmuramoyl-L-alanine amidase
K3556_RS02920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K3556_RS02930	COG0670	Belongs to the BI1 family
K3556_RS02940	COG0583	DNA-binding transcription factor activity
K3556_RS02945	COG1028	Short-chain dehydrogenase reductase Sdr
K3556_RS02945	COG3321	synthase
K3556_RS02945	COG0604	alcohol dehydrogenase
K3556_RS02955	COG0483	inositol monophosphate 1-phosphatase activity
K3556_RS02970	COG0402	S-adenosylhomocysteine deaminase activity
K3556_RS02975	COG2239	Acts as a magnesium transporter
K3556_RS02980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K3556_RS02985	COG1692	metallophosphoesterase
K3556_RS02990	COG0471	metal ion transport
K3556_RS02990	COG3273	potassium ion transport
K3556_RS02995	COG0471	metal ion transport
K3556_RS02995	COG3273	potassium ion transport
K3556_RS03010	COG0217	transcriptional regulatory protein
K3556_RS03025	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K3556_RS03080	COG1012	belongs to the aldehyde dehydrogenase family
K3556_RS03090	COG4166	transmembrane transport
K3556_RS03095	COG0601	transmembrane transport
K3556_RS03100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3556_RS03105	COG0444	Belongs to the ABC transporter superfamily
K3556_RS03130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K3556_RS03130	COG1042	CoA-binding domain protein
K3556_RS03130	COG0045	succinate-CoA ligase (ADP-forming) activity
K3556_RS03135	COG0123	including yeast histone deacetylase and acetoin utilization protein
K3556_RS03140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3556_RS03155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3556_RS03160	COG1079	Belongs to the binding-protein-dependent transport system permease family
K3556_RS03165	COG4603	Belongs to the binding-protein-dependent transport system permease family
K3556_RS03170	COG3845	ABC transporter
K3556_RS03180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3556_RS03200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3556_RS03205	COG2900	Belongs to the SlyX family
K3556_RS03210	COG0124	histidyl-tRNA synthetase
K3556_RS03220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K3556_RS03240	COG0180	Tryptophanyl-tRNA synthetase
K3556_RS03255	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K3556_RS03265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K3556_RS03270	COG0792	nuclease activity
K3556_RS03275	COG0189	ligase activity
K3556_RS03285	COG0606	chelatase, subunit chli
K3556_RS03310	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K3556_RS03320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K3556_RS03330	COG0339	signal peptide processing
K3556_RS03335	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K3556_RS03370	COG3118	belongs to the thioredoxin family
K3556_RS03395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K3556_RS03395	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K3556_RS03400	COG0509	glycine decarboxylation via glycine cleavage system
K3556_RS03405	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3556_RS03425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3556_RS03440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K3556_RS03455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3556_RS03460	COG2814	Major facilitator Superfamily
K3556_RS03480	COG0768	penicillin binding
K3556_RS03485	COG0772	Belongs to the SEDS family
K3556_RS03495	COG1490	D-aminoacyl-tRNA deacylase activity
K3556_RS03520	COG3853	Toxic anion resistance protein (TelA)
K3556_RS03545	COG0552	protein localization to endoplasmic reticulum
K3556_RS03555	COG2917	probably involved in intracellular septation
K3556_RS03560	COG0625	glutathione transferase activity
K3556_RS03570	COG1469	GTP cyclohydrolase I activity
K3556_RS03580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K3556_RS03590	COG0752	glycyl-tRNA synthetase alpha subunit
K3556_RS03600	COG0751	glycine-tRNA ligase activity
K3556_RS03605	COG0574	Belongs to the PEP-utilizing enzyme family
K3556_RS03605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K3556_RS03620	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K3556_RS03625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K3556_RS03640	COG0640	Transcriptional regulator
K3556_RS03650	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K3556_RS03675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K3556_RS03685	COG1802	Transcriptional regulator
K3556_RS03695	COG0505	Belongs to the CarA family
K3556_RS03725	COG3474	cytochrome
K3556_RS03730	COG0321	lipoyl(octanoyl) transferase activity
K3556_RS03740	COG0583	DNA-binding transcription factor activity
K3556_RS03755	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K3556_RS03765	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
K3556_RS03765	COG0028	Belongs to the TPP enzyme family
K3556_RS03785	COG1028	Short-chain dehydrogenase reductase Sdr
K3556_RS03790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K3556_RS03795	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3556_RS03795	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3556_RS03800	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3556_RS03815	COG1609	Transcriptional regulator
K3556_RS03825	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K3556_RS03845	COG0356	it plays a direct role in the translocation of protons across the membrane
K3556_RS03850	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K3556_RS03855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K3556_RS03860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K3556_RS03870	COG2885	chlorophyll binding
K3556_RS03880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K3556_RS03885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3556_RS03910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3556_RS03910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3556_RS03930	COG4175	Glycine betaine
K3556_RS03950	COG3119	arylsulfatase activity
K3556_RS03970	COG1396	sequence-specific DNA binding
K3556_RS03970	COG3800	Transcriptional regulator
K3556_RS03980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K3556_RS04000	COG4770	biotin carboxylase activity
K3556_RS04015	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3556_RS04015	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3556_RS04030	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K3556_RS04045	COG0248	Ppx GppA phosphatase
K3556_RS04050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K3556_RS04060	COG0628	permease
K3556_RS04070	COG0442	prolyl-tRNA aminoacylation
K3556_RS04085	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K3556_RS04090	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K3556_RS04100	COG0071	Belongs to the small heat shock protein (HSP20) family
K3556_RS04110	COG0529	Catalyzes the synthesis of activated sulfate
K3556_RS04110	COG2046	Belongs to the sulfate adenylyltransferase family
K3556_RS04120	COG0492	ferredoxin-NADP+ reductase activity
K3556_RS04125	COG1522	sequence-specific DNA binding
K3556_RS04130	COG1496	oxidoreductase activity
K3556_RS04140	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K3556_RS04160	COG1573	uracil-dna glycosylase
K3556_RS04175	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3556_RS04190	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K3556_RS04195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K3556_RS04210	COG3618	amidohydrolase
K3556_RS04220	COG3842	ATPase activity
K3556_RS04230	COG1175	transmembrane transport
K3556_RS04235	COG0395	ABC-type sugar transport system, permease component
K3556_RS04255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K3556_RS04265	COG1028	Short-chain dehydrogenase reductase Sdr
K3556_RS04270	COG1609	Transcriptional regulator
K3556_RS04290	COG2267	carboxylic ester hydrolase activity
K3556_RS04300	COG2154	pterin-4-alpha-carbinolamine dehydratase
K3556_RS04335	COG2197	response regulator
K3556_RS04340	COG0583	DNA-binding transcription factor activity
K3556_RS04350	COG3384	dioxygenase
K3556_RS04385	COG4214	carbohydrate transport
K3556_RS04395	COG1609	Transcriptional regulator
K3556_RS04400	COG0673	inositol 2-dehydrogenase activity
K3556_RS04410	COG0673	inositol 2-dehydrogenase activity
K3556_RS04415	COG3962	Belongs to the TPP enzyme family
K3556_RS04425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3556_RS04440	COG0673	inositol 2-dehydrogenase activity
K3556_RS04455	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K3556_RS04505	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K3556_RS04505	COG2221	Nitrite and sulphite reductase 4Fe-4S
K3556_RS04515	COG0243	molybdopterin cofactor binding
K3556_RS04520	COG0437	4 iron, 4 sulfur cluster binding
K3556_RS04525	COG0348	domain, Protein
K3556_RS04535	COG3005	denitrification pathway
K3556_RS04540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K3556_RS04545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K3556_RS04550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K3556_RS04570	COG1309	transcriptional regulator
K3556_RS04575	COG1309	transcriptional regulator
K3556_RS04585	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K3556_RS04585	COG0167	dihydroorotate dehydrogenase activity
K3556_RS04590	COG0493	'glutamate synthase
K3556_RS04615	COG0556	nucleotide-excision repair
K3556_RS04635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K3556_RS04640	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K3556_RS04645	COG2204	response regulator
K3556_RS04655	COG0281	malic enzyme
K3556_RS04655	COG0280	phosphate acetyltransferase
K3556_RS04665	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K3556_RS04670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K3556_RS04675	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K3556_RS04700	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3556_RS04700	COG1024	Enoyl-CoA hydratase
K3556_RS04710	COG0183	Belongs to the thiolase family
K3556_RS04715	COG0625	glutathione transferase activity
K3556_RS04725	COG1960	acyl-CoA dehydrogenase activity
K3556_RS04755	COG0534	Mate efflux family protein
K3556_RS04760	COG1393	Belongs to the ArsC family
K3556_RS04775	COG0737	Belongs to the 5'-nucleotidase family
K3556_RS04785	COG2135	peptidase activity
K3556_RS04790	COG0318	PFAM AMP-dependent synthetase and ligase
K3556_RS04795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3556_RS04800	COG0174	glutamine synthetase
K3556_RS04805	COG1177	transmembrane transport
K3556_RS04810	COG1176	ABC-type spermidine putrescine transport system, permease component I
K3556_RS04815	COG3842	ATPase activity
K3556_RS04835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3556_RS04840	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3556_RS04845	COG4149	molybdate abc transporter
K3556_RS04850	COG0725	ABC transporter, periplasmic molybdate-binding protein
K3556_RS04855	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3556_RS04860	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3556_RS04870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K3556_RS04885	COG1492	cobalamin metabolic process
K3556_RS04895	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K3556_RS04905	COG0354	folic acid binding
K3556_RS04910	COG1132	(ABC) transporter
K3556_RS04920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K3556_RS04925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K3556_RS04935	COG0525	valine-tRNA ligase activity
K3556_RS04945	COG0033	Phosphoglucomutase
K3556_RS04960	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K3556_RS04965	COG0583	DNA-binding transcription factor activity
K3556_RS04970	COG0483	inositol monophosphate 1-phosphatase activity
K3556_RS04990	COG1522	sequence-specific DNA binding
K3556_RS05005	COG0012	GTP binding
K3556_RS05015	COG0159	tryptophan synthase activity
K3556_RS05025	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3556_RS05025	COG1618	nucleotide phosphatase activity, acting on free nucleotides
K3556_RS05035	COG4452	Inner membrane protein CreD
K3556_RS05040	COG0659	secondary active sulfate transmembrane transporter activity
K3556_RS05045	COG0813	purine-nucleoside phosphorylase activity
K3556_RS05055	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3556_RS05055	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3556_RS05060	COG2937	Belongs to the GPAT DAPAT family
K3556_RS05065	COG0604	alcohol dehydrogenase
K3556_RS05095	COG0730	response to heat
K3556_RS05105	COG1079	Belongs to the binding-protein-dependent transport system permease family
K3556_RS05110	COG4603	Belongs to the binding-protein-dependent transport system permease family
K3556_RS05115	COG3845	ABC transporter
K3556_RS05120	COG1744	ABC transporter substrate-binding protein PnrA-like
K3556_RS05130	COG1214	PFAM Peptidase M22, glycoprotease
K3556_RS05135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K3556_RS05160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K3556_RS05180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3556_RS05185	COG4311	Sarcosine oxidase, delta subunit
K3556_RS05190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3556_RS05190	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3556_RS05200	COG4977	sequence-specific DNA binding
K3556_RS05210	COG1012	belongs to the aldehyde dehydrogenase family
K3556_RS05230	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K3556_RS05235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K3556_RS05240	COG1126	abc transporter atp-binding protein
K3556_RS05245	COG0765	amino acid transport
K3556_RS05250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3556_RS05260	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
K3556_RS05265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K3556_RS05275	COG3842	ATPase activity
K3556_RS05285	COG1176	ABC-type spermidine putrescine transport system, permease component I
K3556_RS05290	COG1177	transmembrane transport
K3556_RS05295	COG0740	serine-type endopeptidase activity
K3556_RS05300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K3556_RS05310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K3556_RS05320	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K3556_RS05325	COG0439	Biotin carboxylase
K3556_RS05330	COG0511	ligase activity, forming carbon-carbon bonds
K3556_RS05350	COG1396	sequence-specific DNA binding
K3556_RS05350	COG3800	Transcriptional regulator
K3556_RS05355	COG0745	RESPONSE REGULATOR receiver
K3556_RS05365	COG5002	protein histidine kinase activity
K3556_RS05375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K3556_RS05385	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3556_RS05385	COG1024	Enoyl-CoA hydratase
K3556_RS05395	COG3750	Belongs to the UPF0335 family
K3556_RS05415	COG0583	DNA-binding transcription factor activity
K3556_RS05420	COG4336	lyase activity
K3556_RS05435	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3556_RS05450	COG1984	allophanate hydrolase subunit 2
K3556_RS05475	COG1012	belongs to the aldehyde dehydrogenase family
K3556_RS05475	COG2030	dehydratase
K3556_RS05485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K3556_RS05490	COG2151	metal-sulfur cluster biosynthetic enzyme
K3556_RS05500	COG3460	Phenylacetate-CoA oxygenase
K3556_RS05505	COG3396	Phenylacetate-CoA oxygenase
K3556_RS05520	COG1234	tRNA 3'-trailer cleavage
K3556_RS05525	COG0084	hydrolase, TatD family'
K3556_RS05535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K3556_RS05540	COG1686	Belongs to the peptidase S11 family
K3556_RS05570	COG0069	glutamate synthase activity
K3556_RS05580	COG2226	methyltransferase
K3556_RS05610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3556_RS05620	COG1858	cytochrome C peroxidase
K3556_RS05625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3556_RS05640	COG0673	inositol 2-dehydrogenase activity
K3556_RS05645	COG2017	converts alpha-aldose to the beta-anomer
K3556_RS05655	COG0277	FAD linked oxidase domain protein
K3556_RS05670	COG0642	Histidine kinase
K3556_RS05675	COG2197	response regulator
K3556_RS05690	COG2239	Acts as a magnesium transporter
K3556_RS05695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3556_RS05700	COG1396	sequence-specific DNA binding
K3556_RS05700	COG1917	Cupin 2, conserved barrel domain protein
K3556_RS05725	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3556_RS05760	COG0583	DNA-binding transcription factor activity
K3556_RS05770	COG0747	negative chemotaxis
K3556_RS05775	COG0601	transmembrane transport
K3556_RS05780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3556_RS05785	COG0444	Belongs to the ABC transporter superfamily
K3556_RS05790	COG4608	Belongs to the ABC transporter superfamily
K3556_RS05795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3556_RS05795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K3556_RS05820	COG1396	sequence-specific DNA binding
K3556_RS05825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3556_RS05830	COG1960	acyl-CoA dehydrogenase activity
K3556_RS05840	COG0735	belongs to the Fur family
K3556_RS05845	COG1121	(ABC) transporter
K3556_RS05850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K3556_RS05855	COG0280	phosphate acetyltransferase
K3556_RS05860	COG0280	phosphate acetyltransferase
K3556_RS05865	COG0028	Belongs to the TPP enzyme family
K3556_RS05870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3556_RS05885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3556_RS05890	COG1802	Transcriptional regulator
K3556_RS05895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3556_RS05895	COG0519	Catalyzes the synthesis of GMP from XMP
K3556_RS05945	COG1012	belongs to the aldehyde dehydrogenase family
K3556_RS05950	COG5441	Belongs to the UPF0261 family
K3556_RS05960	COG1846	Transcriptional regulator
K3556_RS05995	COG0667	Aldo Keto reductase
K3556_RS06000	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K3556_RS06010	COG0625	glutathione transferase activity
K3556_RS06020	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K3556_RS06030	COG2326	polyphosphate kinase activity
K3556_RS06035	COG2951	lytic endotransglycosylase activity
K3556_RS06040	COG0534	Mate efflux family protein
K3556_RS06065	COG1846	Transcriptional regulator
K3556_RS06075	COG0346	lactoylglutathione lyase activity
K3556_RS06080	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K3556_RS06090	COG1278	Cold shock
K3556_RS06095	COG1393	Belongs to the ArsC family
K3556_RS06115	COG3220	belongs to the UPF0276 family
K3556_RS06125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K3556_RS06135	COG2267	carboxylic ester hydrolase activity
K3556_RS06145	COG3243	poly(R)-hydroxyalkanoic acid synthase
K3556_RS06160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K3556_RS06165	COG0303	'Molybdopterin
K3556_RS06175	COG0134	indole-3-glycerol-phosphate synthase activity
K3556_RS06180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K3556_RS06205	COG0148	phosphopyruvate hydratase activity
K3556_RS06210	COG0697	spore germination
K3556_RS06240	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K3556_RS06245	COG0456	acetyltransferase
K3556_RS06250	COG1957	nucleoside hydrolase
K3556_RS06260	COG2081	HI0933 family
K3556_RS06265	COG0316	Belongs to the HesB IscA family
K3556_RS06270	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K3556_RS06275	COG0018	arginyl-trna synthetase
K3556_RS06285	COG1472	Belongs to the glycosyl hydrolase 3 family
K3556_RS06290	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K3556_RS06295	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K3556_RS06305	COG1183	phosphatidylcholine synthase activity
K3556_RS06310	COG0688	phosphatidylethanolamine metabolic process
K3556_RS06315	COG0717	Belongs to the dCTP deaminase family
K3556_RS06330	COG0776	regulation of translation
K3556_RS06335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K3556_RS06340	COG0416	fatty acid biosynthetic process
K3556_RS06345	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K3556_RS06365	COG0488	(ABC) transporter
K3556_RS06375	COG1272	protein, Hemolysin III
K3556_RS06380	COG0076	glutamate decarboxylase activity
K3556_RS06385	COG0149	triose-phosphate isomerase activity
K3556_RS06390	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
K3556_RS06400	COG0316	Belongs to the HesB IscA family
K3556_RS06405	COG2151	metal-sulfur cluster biosynthetic enzyme
K3556_RS06415	COG0343	queuine tRNA-ribosyltransferase activity
K3556_RS06420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K3556_RS06470	COG0156	8-amino-7-oxononanoate synthase activity
K3556_RS06480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K3556_RS06495	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K3556_RS06500	COG4235	cytochrome complex assembly
K3556_RS06505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3556_RS06515	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3556_RS06515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3556_RS06560	COG5265	(ABC) transporter
K3556_RS06565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3556_RS06585	COG1160	GTP binding
K3556_RS06590	COG0737	Belongs to the 5'-nucleotidase family
K3556_RS06600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K3556_RS06605	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K3556_RS06610	COG1028	Short-chain dehydrogenase reductase Sdr
K3556_RS06615	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K3556_RS06635	COG1127	ABC transporter
K3556_RS06640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K3556_RS06680	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K3556_RS06695	COG0544	peptidyl-prolyl cis-trans isomerase activity
K3556_RS06705	COG0584	glycerophosphoryl diester phosphodiesterase
K3556_RS06715	COG0359	binds to the 23S rRNA
K3556_RS06720	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K3556_RS06725	COG0360	Binds together with S18 to 16S ribosomal RNA
K3556_RS06735	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K3556_RS06745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3556_RS06750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K3556_RS06755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K3556_RS06760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K3556_RS06775	COG4695	Portal protein
K3556_RS06850	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K3556_RS06865	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3556_RS06870	COG0022	dehydrogenase e1 component
K3556_RS06870	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3556_RS06875	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K3556_RS06880	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K3556_RS06885	COG3588	fructose-bisphosphate aldolase
K3556_RS06920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K3556_RS06930	COG0436	Aminotransferase
K3556_RS06935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K3556_RS06940	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K3556_RS06980	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K3556_RS06990	COG0308	aminopeptidase N
K3556_RS06995	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K3556_RS07020	COG0436	Aminotransferase
K3556_RS07025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K3556_RS07025	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3556_RS07035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K3556_RS07060	COG1741	Belongs to the pirin family
K3556_RS07080	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K3556_RS07095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K3556_RS07100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K3556_RS07105	COG0531	amino acid
K3556_RS07120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K3556_RS07125	COG1181	Belongs to the D-alanine--D-alanine ligase family
K3556_RS07130	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K3556_RS07135	COG0849	cell division
K3556_RS07140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K3556_RS07145	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K3556_RS07150	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3556_RS07160	COG0277	FAD linked oxidase domain protein
K3556_RS07170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K3556_RS07175	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K3556_RS07185	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K3556_RS07200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K3556_RS07210	COG3577	Aspartyl protease
K3556_RS07215	COG2095	MarC family integral membrane protein
K3556_RS07220	COG0488	(ABC) transporter
K3556_RS07230	COG0105	UTP biosynthetic process
K3556_RS07270	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K3556_RS07295	COG0328	RNA-DNA hybrid ribonuclease activity
K3556_RS07305	COG0582	viral genome integration into host DNA
K3556_RS07395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K3556_RS07415	COG0577	efflux transmembrane transporter activity
K3556_RS07415	COG1136	(ABC) transporter
K3556_RS07420	COG1136	(ABC) transporter
K3556_RS07435	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K3556_RS07440	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K3556_RS07450	COG2166	iron-sulfur cluster assembly
K3556_RS07465	COG5012	cobalamin binding
K3556_RS07475	COG0646	methionine synthase
K3556_RS07475	COG1410	methionine synthase
K3556_RS07480	COG0392	lysyltransferase activity
K3556_RS07490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K3556_RS07495	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K3556_RS07500	COG0047	phosphoribosylformylglycinamidine synthase activity
K3556_RS07510	COG2204	response regulator
K3556_RS07535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3556_RS07545	COG0006	proline dipeptidase activity
K3556_RS07550	COG3608	succinylglutamate desuccinylase aspartoacylase
K3556_RS07555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3556_RS07560	COG0189	ligase activity
K3556_RS07560	COG4067	protein conserved in archaea
K3556_RS07565	COG0189	ligase activity
K3556_RS07575	COG0598	Magnesium transport protein CorA
K3556_RS07580	COG0800	Aldolase
K3556_RS07585	COG0129	dihydroxy-acid dehydratase activity
K3556_RS07645	COG0542	response to heat
K3556_RS07655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K3556_RS07680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K3556_RS07685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K3556_RS07695	COG1217	gtp-binding protein TYPA
K3556_RS07700	COG2076	Multidrug Resistance protein
K3556_RS07705	COG1522	sequence-specific DNA binding
K3556_RS07715	COG0121	glutamine amidotransferase
K3556_RS07720	COG1024	Enoyl-CoA hydratase
K3556_RS07735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K3556_RS07780	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3556_RS07785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3556_RS07800	COG0433	COG0433 Predicted ATPase
K3556_RS07810	COG4536	flavin adenine dinucleotide binding
K3556_RS07820	COG0004	ammonium transporteR
K3556_RS07825	COG1546	Belongs to the CinA family
K3556_RS07825	COG1058	Belongs to the CinA family
K3556_RS07835	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K3556_RS07835	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K3556_RS07840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K3556_RS07845	COG3852	Histidine kinase
K3556_RS07850	COG2204	response regulator
K3556_RS07855	COG5000	phosphorelay sensor kinase activity
K3556_RS07860	COG2204	response regulator
K3556_RS07865	COG0569	domain protein
K3556_RS07880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K3556_RS07885	COG2366	antibiotic biosynthetic process
K3556_RS07890	COG2084	Dehydrogenase
K3556_RS07910	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K3556_RS07915	COG2814	Major facilitator Superfamily
K3556_RS07940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3556_RS07940	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3556_RS07945	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3556_RS07945	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3556_RS07950	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3556_RS07960	COG0798	PFAM Bile acid sodium symporter
K3556_RS07970	COG1028	Short-chain dehydrogenase reductase Sdr
K3556_RS07990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K3556_RS07995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K3556_RS08010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K3556_RS08015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3556_RS08020	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K3556_RS08025	COG0346	lactoylglutathione lyase activity
K3556_RS08035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K3556_RS08040	COG1612	heme a metabolic process
K3556_RS08045	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K3556_RS08070	COG2945	thiolester hydrolase activity
K3556_RS08075	COG1959	2 iron, 2 sulfur cluster binding
K3556_RS08080	COG1104	cysteine desulfurase activity
K3556_RS08085	COG0719	Fe-S assembly protein
K3556_RS08095	COG0393	Putative heavy-metal-binding
K3556_RS08100	COG0396	ATPase activity
K3556_RS08105	COG0719	Fe-S assembly protein
K3556_RS08120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K3556_RS08125	COG1309	transcriptional regulator
K3556_RS08130	COG2326	polyphosphate kinase activity
K3556_RS08135	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K3556_RS08170	COG0519	Catalyzes the synthesis of GMP from XMP
K3556_RS08170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3556_RS08175	COG5598	trimethylamine methyltransferase
K3556_RS08195	COG5002	protein histidine kinase activity
K3556_RS08205	COG0573	inorganic phosphate transmembrane transporter activity
K3556_RS08215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K3556_RS08225	COG0745	RESPONSE REGULATOR receiver
K3556_RS08235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K3556_RS08245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K3556_RS08250	COG0052	Belongs to the universal ribosomal protein uS2 family
K3556_RS08255	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K3556_RS08255	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K3556_RS08260	COG2313	pseudouridylate synthase activity
K3556_RS08265	COG0745	RESPONSE REGULATOR receiver
K3556_RS08275	COG0482	sulfurtransferase activity
K3556_RS08280	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3556_RS08285	COG3494	Protein of unknown function (DUF1009)
K3556_RS08290	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3556_RS08295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K3556_RS08305	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3556_RS08315	COG0750	zinc metalloprotease
K3556_RS08320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K3556_RS08330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K3556_RS08335	COG0233	cytoplasmic translational termination
K3556_RS08340	COG0528	UMP kinase activity
K3556_RS08345	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K3556_RS08365	COG0741	lytic transglycosylase activity
K3556_RS08370	COG0629	single-stranded DNA binding
K3556_RS08375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K3556_RS08380	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K3556_RS08395	COG4974	Belongs to the 'phage' integrase family
K3556_RS08415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K3556_RS08425	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K3556_RS08445	COG0194	GDP metabolic process
K3556_RS08450	COG1561	YicC-like family, N-terminal region
K3556_RS08460	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K3556_RS08515	COG0626	cystathionine gamma-synthase activity
K3556_RS08540	COG2321	neutral zinc metallopeptidase
K3556_RS08545	COG1238	metal cluster binding
K3556_RS08590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K3556_RS08595	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K3556_RS08600	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K3556_RS08620	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K3556_RS08625	COG3743	rRNA binding
K3556_RS08625	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K3556_RS08630	COG0457	Tetratricopeptide repeat
K3556_RS08655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3556_RS08655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3556_RS08665	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3556_RS08670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3556_RS08685	COG1012	belongs to the aldehyde dehydrogenase family
K3556_RS08690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K3556_RS08695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K3556_RS08700	COG2267	carboxylic ester hydrolase activity
K3556_RS08710	COG0583	DNA-binding transcription factor activity
K3556_RS08735	COG1012	belongs to the aldehyde dehydrogenase family
K3556_RS08740	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K3556_RS08745	COG0248	Ppx GppA phosphatase
K3556_RS08755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K3556_RS08760	COG0646	methionine synthase
K3556_RS08760	COG1410	methionine synthase
K3556_RS08765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3556_RS08785	COG0730	response to heat
K3556_RS08790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K3556_RS08805	COG1061	Type III restriction enzyme res subunit
K3556_RS08810	COG1002	Type II restriction enzyme, methylase subunits
K3556_RS08825	COG0328	RNA-DNA hybrid ribonuclease activity
K3556_RS08925	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3556_RS08945	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K3556_RS08950	COG0737	Belongs to the 5'-nucleotidase family
K3556_RS08955	COG3258	Cytochrome c
K3556_RS08975	COG0785	Cytochrome C biogenesis protein
K3556_RS08990	COG2391	methyltransferase activity
K3556_RS09010	COG1278	Cold shock
K3556_RS09020	COG2873	o-acetylhomoserine
K3556_RS09025	COG2968	Membrane
K3556_RS09040	COG1522	sequence-specific DNA binding
K3556_RS09045	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K3556_RS09050	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K3556_RS09055	COG1329	Transcriptional regulator
K3556_RS09060	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K3556_RS09065	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K3556_RS09075	COG0457	Tetratricopeptide repeat
K3556_RS09090	COG0166	Belongs to the GPI family
K3556_RS09100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K3556_RS09130	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K3556_RS09140	COG1797	cobyrinic acid a,c-diamide synthase activity
K3556_RS09145	COG2814	Major facilitator Superfamily
K3556_RS09150	COG4175	Glycine betaine
K3556_RS09150	COG0517	IMP dehydrogenase activity
K3556_RS09155	COG4176	ABC-type proline glycine betaine transport system permease component
K3556_RS09170	COG2188	Transcriptional regulator
K3556_RS09200	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K3556_RS09210	COG3038	cytochrome b561
K3556_RS09225	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K3556_RS09230	COG0028	Belongs to the TPP enzyme family
K3556_RS09235	COG0440	acetolactate synthase activity
K3556_RS09245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K3556_RS09265	COG0259	pyridoxamine-phosphate oxidase activity
K3556_RS09270	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K3556_RS09275	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K3556_RS09285	COG2890	protein-(glutamine-N5) methyltransferase activity
K3556_RS09290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K3556_RS09305	COG0010	Belongs to the arginase family
K3556_RS09310	COG1473	amidohydrolase
K3556_RS09315	COG3956	TIGRFAM MazG family protein
K3556_RS09320	COG1840	ABC-type Fe3 transport system, periplasmic component
K3556_RS09345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K3556_RS09355	COG2814	Major facilitator Superfamily
K3556_RS09360	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K3556_RS09370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K3556_RS09375	COG2833	Protein of unknown function (DUF455)
K3556_RS09380	COG0739	heme binding
K3556_RS09400	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K3556_RS09410	COG3842	ATPase activity
K3556_RS09415	COG0366	Alpha amylase catalytic
K3556_RS09420	COG0395	ABC-type sugar transport system, permease component
K3556_RS09425	COG1175	transmembrane transport
K3556_RS09430	COG1653	transport
K3556_RS09435	COG1609	Transcriptional regulator
K3556_RS09440	COG2723	6-phospho-beta-galactosidase activity
K3556_RS09445	COG0837	glucose binding
K3556_RS09460	COG3246	L-lysine catabolic process to acetate
K3556_RS09470	COG0824	Thioesterase
K3556_RS09470	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3556_RS09475	COG1960	acyl-CoA dehydrogenase activity
K3556_RS09490	COG3273	potassium ion transport
K3556_RS09490	COG0471	metal ion transport
K3556_RS09495	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K3556_RS09500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K3556_RS09505	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
K3556_RS09510	COG1940	carbohydrate kinase activity
K3556_RS09515	COG2222	sugar isomerase
K3556_RS09520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K3556_RS09525	COG0673	inositol 2-dehydrogenase activity
K3556_RS09530	COG3842	ATPase activity
K3556_RS09540	COG0395	ABC-type sugar transport system, permease component
K3556_RS09550	COG2188	Transcriptional regulator
K3556_RS09560	COG3842	ATPase activity
K3556_RS09565	COG0395	ABC-type sugar transport system, permease component
K3556_RS09570	COG1175	transmembrane transport
K3556_RS09595	COG0306	phosphate transporter
K3556_RS09610	COG3842	ATPase activity
K3556_RS09615	COG1177	transmembrane transport
K3556_RS09645	COG2072	flavoprotein involved in K transport
K3556_RS09655	COG1522	sequence-specific DNA binding
K3556_RS09660	COG1063	alcohol dehydrogenase
K3556_RS09665	COG0156	8-amino-7-oxononanoate synthase activity
K3556_RS09675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K3556_RS09680	COG3264	Mechanosensitive ion channel
K3556_RS09680	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3556_RS09690	COG0494	nUDIX hydrolase
K3556_RS09700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K3556_RS09705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K3556_RS09710	COG0071	Belongs to the small heat shock protein (HSP20) family
K3556_RS09715	COG0604	alcohol dehydrogenase
K3556_RS09720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3556_RS09735	COG1802	Transcriptional regulator
K3556_RS09740	COG2340	Cysteine-rich secretory protein family
K3556_RS09770	COG2059	Chromate
K3556_RS09780	COG0114	fumarate hydratase activity
K3556_RS09805	COG0785	Cytochrome C biogenesis protein
K3556_RS09810	COG0425	Belongs to the sulfur carrier protein TusA family
K3556_RS09815	COG1530	ribonuclease E activity
K3556_RS09820	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K3556_RS09825	COG1164	Oligoendopeptidase f
K3556_RS09840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K3556_RS09860	COG0564	pseudouridine synthase activity
K3556_RS09900	COG2133	pyrroloquinoline quinone binding
K3556_RS09915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K3556_RS09920	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K3556_RS09935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K3556_RS09960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K3556_RS09960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K3556_RS09965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K3556_RS09975	COG0432	Pfam Uncharacterised protein family UPF0047
K3556_RS09985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K3556_RS09990	COG0358	DNA primase activity
K3556_RS10020	COG1335	isochorismatase
K3556_RS10025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K3556_RS10035	COG5001	Diguanylate cyclase
K3556_RS10035	COG5002	protein histidine kinase activity
K3556_RS10035	COG3447	MASE1 domain protein
K3556_RS10045	COG0546	phosphoglycolate phosphatase activity
K3556_RS10055	COG3706	GGDEF domain
K3556_RS10100	COG0667	Aldo Keto reductase
K3556_RS10105	COG1028	Short-chain dehydrogenase reductase Sdr
K3556_RS10110	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K3556_RS10125	COG0513	Belongs to the DEAD box helicase family
K3556_RS10135	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K3556_RS10145	COG1007	ATP synthesis coupled electron transport
K3556_RS10160	COG0713	ATP synthesis coupled electron transport
K3556_RS10175	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3556_RS10180	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K3556_RS10205	COG3743	rRNA binding
K3556_RS10205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K3556_RS10215	COG0649	NAD binding
K3556_RS10225	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3556_RS10230	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3556_RS10240	COG1024	Enoyl-CoA hydratase
K3556_RS10255	COG4770	biotin carboxylase activity
K3556_RS10265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K3556_RS10275	COG1960	acyl-CoA dehydrogenase activity
K3556_RS10280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K3556_RS10285	COG0546	phosphoglycolate phosphatase activity
K3556_RS10290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K3556_RS10310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3556_RS10320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K3556_RS10325	COG1473	amidohydrolase
K3556_RS10335	COG0601	transmembrane transport
K3556_RS10340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3556_RS10345	COG2391	methyltransferase activity
K3556_RS10360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K3556_RS10370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K3556_RS10390	COG2001	Belongs to the MraZ family
K3556_RS10395	COG0489	protein tyrosine kinase activity
K3556_RS10410	COG0210	DNA helicase
K3556_RS10415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K3556_RS10445	COG2994	toxin metabolic process
K3556_RS10460	COG0277	FAD linked oxidase domain protein
K3556_RS10465	COG1028	Short-chain dehydrogenase reductase Sdr
K3556_RS10475	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K3556_RS10475	COG0546	phosphoglycolate phosphatase activity
K3556_RS10500	COG4964	Belongs to the GSP D family
K3556_RS10555	COG1201	RNA secondary structure unwinding
K3556_RS10570	COG1024	Enoyl-CoA hydratase
K3556_RS10585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K3556_RS10590	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K3556_RS10605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K3556_RS10610	COG0037	tRNA processing
K3556_RS10620	COG2885	chlorophyll binding
K3556_RS10630	COG3142	Participates in the control of copper homeostasis
K3556_RS10640	COG0848	biopolymer transport protein
K3556_RS10650	COG0824	Thioesterase
K3556_RS10665	COG2255	four-way junction helicase activity
K3556_RS10670	COG0632	four-way junction helicase activity
K3556_RS10675	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K3556_RS10685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K3556_RS10690	COG3239	Fatty acid desaturase
K3556_RS10700	COG0330	HflC and HflK could
K3556_RS10705	COG0330	HflC and HflK could
K3556_RS10715	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K3556_RS10720	COG2832	Protein of unknown function (DUF454)
K3556_RS10725	COG1760	l-serine dehydratase
K3556_RS10745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K3556_RS10755	COG0504	CTP synthase activity
K3556_RS10785	COG4160	amino acid transport
K3556_RS10790	COG0519	Catalyzes the synthesis of GMP from XMP
K3556_RS10795	COG0174	glutamine synthetase
K3556_RS10800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K3556_RS10805	COG0583	DNA-binding transcription factor activity
K3556_RS10810	COG0658	competence protein
K3556_RS10810	COG2333	competence protein COMEC
K3556_RS10815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3556_RS10830	COG1024	Enoyl-CoA hydratase
K3556_RS10835	COG3088	subunit of a heme lyase
K3556_RS10840	COG1138	Cytochrome C-type biogenesis protein
K3556_RS10865	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K3556_RS10870	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K3556_RS10875	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K3556_RS10890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K3556_RS10905	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K3556_RS10925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K3556_RS10935	COG2354	Protein conserved in bacteria
K3556_RS10960	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K3556_RS10965	COG0517	IMP dehydrogenase activity
K3556_RS10965	COG0617	tRNA 3'-terminal CCA addition
K3556_RS10965	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K3556_RS10985	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
K3556_RS11005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3556_RS11015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3556_RS11020	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3556_RS11025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3556_RS11040	COG2124	cytochrome p450
K3556_RS11045	COG1522	sequence-specific DNA binding
K3556_RS11055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K3556_RS11060	COG0175	sulfate reduction
K3556_RS11090	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K3556_RS11095	COG2226	methyltransferase
K3556_RS11100	COG0583	DNA-binding transcription factor activity
K3556_RS11110	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K3556_RS11110	COG3608	succinylglutamate desuccinylase aspartoacylase
K3556_RS11125	COG0418	dihydroorotase activity
K3556_RS11130	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K3556_RS11145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K3556_RS11175	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K3556_RS11180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3556_RS11190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K3556_RS11195	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K3556_RS11200	COG4133	protoheme IX ABC transporter activity
K3556_RS11205	COG3737	Protein of unknown function (DUF498/DUF598)
K3556_RS11215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K3556_RS11220	COG1862	Preprotein translocase
K3556_RS11230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K3556_RS11240	COG0805	protein transport
K3556_RS11250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K3556_RS11255	COG3842	ATPase activity
K3556_RS11260	COG2814	Major facilitator Superfamily
K3556_RS11265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3556_RS11305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K3556_RS11310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K3556_RS11315	COG0659	secondary active sulfate transmembrane transporter activity
K3556_RS11320	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K3556_RS11325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K3556_RS11340	COG0612	Peptidase, M16
K3556_RS11350	COG3346	SURF1 family
K3556_RS11360	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K3556_RS11370	COG0109	protoheme IX farnesyltransferase activity
K3556_RS11380	COG0312	modulator of DNA gyrase
K3556_RS11385	COG0758	DNA mediated transformation
K3556_RS11385	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K3556_RS11390	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K3556_RS11395	COG2267	carboxylic ester hydrolase activity
K3556_RS11410	COG1396	sequence-specific DNA binding
K3556_RS11425	COG0131	Imidazoleglycerol-phosphate dehydratase
K3556_RS11430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K3556_RS11440	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K3556_RS11450	COG0107	imidazoleglycerol-phosphate synthase activity
K3556_RS11455	COG0140	phosphoribosyl-ATP diphosphatase activity
K3556_RS11460	COG1832	CoA-binding protein
K3556_RS11470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K3556_RS11485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K3556_RS11485	COG0512	Glutamine amidotransferase of anthranilate synthase
K3556_RS11490	COG3971	2-oxopent-4-enoate hydratase activity
K3556_RS11495	COG0179	Fumarylacetoacetate (FAA) hydrolase
K3556_RS11500	COG3384	dioxygenase
K3556_RS11505	COG1012	belongs to the aldehyde dehydrogenase family
K3556_RS11515	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K3556_RS11525	COG0251	oxidation-reduction process
K3556_RS11535	COG0583	DNA-binding transcription factor activity
K3556_RS11540	COG2515	1-aminocyclopropane-1-carboxylate deaminase
K3556_RS11550	COG0251	oxidation-reduction process
K3556_RS11555	COG0583	DNA-binding transcription factor activity
K3556_RS11565	COG3448	diguanylate cyclase activity
K3556_RS11565	COG4175	Glycine betaine
K3556_RS11570	COG4176	ABC-type proline glycine betaine transport system permease component
K3556_RS11575	COG2267	carboxylic ester hydrolase activity
K3556_RS11585	COG1840	ABC-type Fe3 transport system, periplasmic component
K3556_RS11595	COG3842	ATPase activity
K3556_RS11615	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K3556_RS11630	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K3556_RS11640	COG5328	Belongs to the UPF0262 family
K3556_RS11645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K3556_RS11655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K3556_RS11685	COG0318	PFAM AMP-dependent synthetase and ligase
K3556_RS11690	COG1132	(ABC) transporter
K3556_RS11710	COG1054	Belongs to the UPF0176 family
K3556_RS11730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K3556_RS11750	COG0228	four-way junction DNA binding
K3556_RS11755	COG0778	Nitroreductase
K3556_RS11765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K3556_RS11775	COG0336	Belongs to the RNA methyltransferase TrmD family
K3556_RS11785	COG0335	large ribosomal subunit rRNA binding
K3556_RS11790	COG0254	rRNA binding
K3556_RS11800	COG2151	metal-sulfur cluster biosynthetic enzyme
K3556_RS11800	COG0489	protein tyrosine kinase activity
K3556_RS11805	COG0601	transmembrane transport
K3556_RS11810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3556_RS11835	COG3191	aminopeptidase activity
K3556_RS11860	COG2304	oxidoreductase activity
K3556_RS11865	COG0697	spore germination
K3556_RS11870	COG0071	Belongs to the small heat shock protein (HSP20) family
K3556_RS11885	COG0247	lactate metabolic process
K3556_RS11890	COG0277	FAD linked oxidase domain protein
K3556_RS11895	COG0277	FAD linked oxidase domain protein
K3556_RS11920	COG0714	Associated with various cellular activities
K3556_RS11930	COG3938	Belongs to the proline racemase family
K3556_RS11935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K3556_RS11935	COG0116	Belongs to the methyltransferase superfamily
K3556_RS11940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3556_RS11945	COG1126	abc transporter atp-binding protein
K3556_RS11950	COG0765	amino acid transport
K3556_RS11955	COG5002	protein histidine kinase activity
K3556_RS11955	COG2176	DNA-directed DNA polymerase activity
K3556_RS11965	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
K3556_RS11970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K3556_RS11985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3556_RS12000	COG0318	PFAM AMP-dependent synthetase and ligase
K3556_RS12005	COG3842	ATPase activity
K3556_RS12010	COG0395	ABC-type sugar transport system, permease component
K3556_RS12015	COG1175	transmembrane transport
K3556_RS12055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3556_RS12115	COG3639	organic phosphonate transmembrane transporter activity
K3556_RS12120	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K3556_RS12130	COG0546	phosphoglycolate phosphatase activity
K3556_RS12165	COG1115	amino acid carrier protein
K3556_RS12185	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3556_RS12190	COG0567	Dehydrogenase, E1 component
K3556_RS12205	COG0045	succinate-CoA ligase (ADP-forming) activity
K3556_RS12210	COG0039	L-malate dehydrogenase activity
K3556_RS12220	COG2301	Belongs to the HpcH HpaI aldolase family
K3556_RS12235	COG2030	dehydratase
K3556_RS12265	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K3556_RS12270	COG4181	ATPase activity
K3556_RS12280	COG2197	response regulator
K3556_RS12300	COG0348	domain, Protein
K3556_RS12305	COG2010	Cytochrome c
K3556_RS12330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3556_RS12335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3556_RS12355	COG0459	protein refolding
K3556_RS12360	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K3556_RS12370	COG1227	inorganic diphosphatase activity
K3556_RS12385	COG2030	dehydratase
K3556_RS12390	COG0196	riboflavin kinase activity
K3556_RS12400	COG2983	Belongs to the UPF0260 family
K3556_RS12410	COG0596	Alpha beta hydrolase
K3556_RS12435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K3556_RS12440	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K3556_RS12445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K3556_RS12450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K3556_RS12455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K3556_RS12470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K3556_RS12490	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
K3556_RS12505	COG0287	Prephenate dehydrogenase
K3556_RS12510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K3556_RS12515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K3556_RS12530	COG1338	Plays a role in the flagellum-specific transport system
K3556_RS12535	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K3556_RS12545	COG1766	The M ring may be actively involved in energy transduction
K3556_RS12565	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K3556_RS12580	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K3556_RS12585	COG1684	flagellar biosynthetic protein fliR
K3556_RS12590	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K3556_RS12600	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K3556_RS12605	COG0193	aminoacyl-tRNA hydrolase activity
K3556_RS12620	COG0133	tryptophan synthase activity
K3556_RS12625	COG0135	phosphoribosylanthranilate isomerase activity
K3556_RS12635	COG0776	regulation of translation
K3556_RS12640	COG0539	negative regulation of cytoplasmic translation
K3556_RS12650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K3556_RS12655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K3556_RS12660	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K3556_RS12665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K3556_RS12670	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K3556_RS12675	COG4535	Mg2 and Co2 transporter CorC
K3556_RS12680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K3556_RS12685	COG1702	phosphate starvation-inducible protein PhoH
K3556_RS12690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3556_RS12700	COG1047	Peptidyl-prolyl cis-trans
K3556_RS12710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K3556_RS12715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K3556_RS12720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K3556_RS12750	COG4948	Mandelate Racemase Muconate Lactonizing
K3556_RS12770	COG2824	Alkylphosphonate utilization operon protein PhnA
K3556_RS12780	COG0481	GTPase activity
K3556_RS12790	COG1522	sequence-specific DNA binding
K3556_RS12800	COG1105	Belongs to the carbohydrate kinase PfkB family
K3556_RS12810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K3556_RS12825	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K3556_RS12840	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K3556_RS12855	COG1132	(ABC) transporter
K3556_RS12860	COG1703	isobutyryl-CoA mutase activity
K3556_RS12865	COG1643	Atp-dependent helicase
K3556_RS12875	COG0306	phosphate transporter
K3556_RS12880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K3556_RS12885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K3556_RS12900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3556_RS12930	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K3556_RS12940	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K3556_RS12950	COG0346	lactoylglutathione lyase activity
K3556_RS12970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K3556_RS12985	COG0560	Phosphoserine phosphatase
K3556_RS12985	COG3830	Belongs to the UPF0237 family
K3556_RS13005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K3556_RS13010	COG4191	Histidine kinase
K3556_RS13035	COG2171	N-acyltransferase activity
K3556_RS13060	COG0557	exoribonuclease II activity
K3556_RS13065	COG2951	lytic endotransglycosylase activity
K3556_RS13085	COG1051	belongs to the nudix hydrolase family
K3556_RS13090	COG0793	Belongs to the peptidase S41A family
K3556_RS13100	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K3556_RS13105	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K3556_RS13110	COG0799	negative regulation of ribosome biogenesis
K3556_RS13115	COG3264	Mechanosensitive ion channel
K3556_RS13115	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3556_RS13120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K3556_RS13130	COG0066	3-isopropylmalate dehydratase activity
K3556_RS13145	COG0473	3-isopropylmalate dehydrogenase activity
K3556_RS13185	COG0463	Glycosyl transferase, family 2
K3556_RS13205	COG0435	Glutathione S-transferase
K3556_RS13215	COG1522	sequence-specific DNA binding
K3556_RS13240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K3556_RS13245	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K3556_RS13255	COG0300	oxidoreductase activity
K3556_RS13260	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K3556_RS13265	COG3806	Anti-sigma factor
K3556_RS13270	COG1595	DNA-templated transcription, initiation
K3556_RS13280	COG0778	Nitroreductase
K3556_RS13290	COG1872	DUF167
K3556_RS13295	COG3152	Membrane
K3556_RS13300	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K3556_RS13315	COG0540	Belongs to the ATCase OTCase family
K3556_RS13320	COG1573	uracil-dna glycosylase
K3556_RS13330	COG0521	Mo-molybdopterin cofactor biosynthetic process
K3556_RS13340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3556_RS13350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K3556_RS13365	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K3556_RS13370	COG0142	geranyltranstransferase activity
K3556_RS13395	COG1028	Short-chain dehydrogenase reductase Sdr
K3556_RS13405	COG2771	luxR family
K3556_RS13405	COG2200	EAL domain
K3556_RS13410	COG2818	Glycosylase
K3556_RS13415	COG2951	lytic endotransglycosylase activity
K3556_RS13420	COG0165	Argininosuccinate lyase
K3556_RS13425	COG0019	diaminopimelate decarboxylase activity
K3556_RS13435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K3556_RS13445	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K3556_RS13455	COG1162	GTPase activity
K3556_RS13465	COG0737	Belongs to the 5'-nucleotidase family
K3556_RS13480	COG0077	Prephenate dehydratase
K3556_RS13490	COG4166	transmembrane transport
K3556_RS13495	COG4174	ABC transporter (Permease)
K3556_RS13500	COG4239	(ABC) transporter, permease
K3556_RS13505	COG4172	Belongs to the ABC transporter superfamily
K3556_RS13510	COG1686	Belongs to the peptidase S11 family
K3556_RS13520	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K3556_RS13525	COG2813	Specifically methylates the guanine in position
K3556_RS13540	COG0408	coproporphyrinogen oxidase activity
K3556_RS13550	COG0183	Belongs to the thiolase family
K3556_RS13555	COG0181	hydroxymethylbilane synthase activity
K3556_RS13560	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K3556_RS13570	COG0513	Belongs to the DEAD box helicase family
K3556_RS13575	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K3556_RS13595	COG4589	Belongs to the CDS family
K3556_RS13605	COG0288	reversible hydration of carbon dioxide
K3556_RS13615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K3556_RS13620	COG0791	NLP P60 protein
K3556_RS13630	COG2050	protein possibly involved in aromatic compounds catabolism
K3556_RS13655	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K3556_RS13670	COG0679	Auxin Efflux Carrier
K3556_RS13680	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K3556_RS13685	COG1671	Belongs to the UPF0178 family
K3556_RS13695	COG2897	thiosulfate sulfurtransferase activity
K3556_RS13715	COG0004	ammonium transporteR
K3556_RS13720	COG0347	Belongs to the P(II) protein family
K3556_RS13725	COG4953	penicillin-binding protein 1C
K3556_RS13760	COG0678	peroxiredoxin activity
K3556_RS13760	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K3556_RS13770	COG0742	ribosomal rna small subunit methyltransferase
K3556_RS13775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3556_RS13780	COG0024	Methionine aminopeptidase
K3556_RS13785	COG1489	DNA binding
K3556_RS13790	COG1546	Belongs to the CinA family
K3556_RS13790	COG1058	Belongs to the CinA family
K3556_RS13810	COG0583	DNA-binding transcription factor activity
K3556_RS13820	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3556_RS13820	COG1902	pentaerythritol trinitrate reductase activity
K3556_RS13845	COG1266	CAAX protease self-immunity
K3556_RS13850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K3556_RS13855	COG0285	dihydrofolate synthase activity
K3556_RS13860	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K3556_RS13865	COG2271	Major facilitator Superfamily
K3556_RS13870	COG1522	sequence-specific DNA binding
K3556_RS13875	COG0686	Belongs to the AlaDH PNT family
K3556_RS13890	COG1970	mechanosensitive ion channel activity
K3556_RS13900	COG0072	phenylalanine-tRNA ligase activity
K3556_RS13900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3556_RS13915	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K3556_RS13925	COG3795	YCII-related domain
K3556_RS13940	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K3556_RS13945	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K3556_RS13955	COG0469	pyruvate kinase activity
K3556_RS13990	COG4948	Mandelate Racemase Muconate Lactonizing
K3556_RS14010	COG0825	malonyl-CoA metabolic process
K3556_RS14015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K3556_RS14035	COG2884	Cell division ATP-binding protein ftsE
K3556_RS14190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K3556_RS14195	COG0069	glutamate synthase activity
K3556_RS14210	COG0284	orotidine-5'-phosphate decarboxylase activity
K3556_RS14235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K3556_RS14250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K3556_RS14280	COG0559	Belongs to the binding-protein-dependent transport system permease family
K3556_RS14320	COG3383	formate dehydrogenase (NAD+) activity
K3556_RS14345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K3556_RS14395	COG1309	transcriptional regulator
K3556_RS14400	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K3556_RS14405	COG1611	Belongs to the LOG family
K3556_RS14410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K3556_RS14415	COG1129	ABC transporter
K3556_RS14415	COG0842	Transport permease protein
K3556_RS14420	COG0842	Transport permease protein
K3556_RS14445	COG0612	Peptidase, M16
K3556_RS14450	COG0612	Peptidase, M16
K3556_RS14460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K3556_RS14465	COG0138	bifunctional purine biosynthesis protein purh
K3556_RS14475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K3556_RS14485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K3556_RS14490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K3556_RS14495	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K3556_RS14500	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K3556_RS14520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K3556_RS14530	COG1185	polyribonucleotide nucleotidyltransferase activity
K3556_RS14550	COG3842	ATPase activity
K3556_RS14595	COG3181	Tripartite tricarboxylate transporter family receptor
K3556_RS14605	COG0642	Histidine kinase
K3556_RS14615	COG0129	dihydroxy-acid dehydratase activity
K3556_RS14620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K3556_RS14625	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K3556_RS14630	COG1132	(ABC) transporter
K3556_RS14670	COG3206	protein involved in exopolysaccharide biosynthesis
K3556_RS14670	COG0489	protein tyrosine kinase activity
K3556_RS14675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K3556_RS14695	COG0583	DNA-binding transcription factor activity
K3556_RS14700	COG4608	Belongs to the ABC transporter superfamily
K3556_RS14710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3556_RS14715	COG0601	transmembrane transport
K3556_RS14730	COG1309	transcriptional regulator
K3556_RS14810	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K3556_RS14815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3556_RS14850	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K3556_RS14860	COG4143	(ABC) transporter
K3556_RS14865	COG0697	spore germination
K3556_RS14870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K3556_RS14890	COG0776	regulation of translation
K3556_RS14895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K3556_RS14900	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K3556_RS14910	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K3556_RS14915	COG0142	geranyltranstransferase activity
K3556_RS14920	COG1722	exodeoxyribonuclease VII activity
K3556_RS14925	COG0123	including yeast histone deacetylase and acetoin utilization protein
K3556_RS14930	COG0745	RESPONSE REGULATOR receiver
K3556_RS14935	COG1846	Transcriptional regulator
K3556_RS14950	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K3556_RS14960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K3556_RS14980	COG1968	undecaprenyl-diphosphatase activity
K3556_RS15055	COG3842	ATPase activity
K3556_RS15060	COG3842	ATPase activity
K3556_RS15065	COG1175	transmembrane transport
K3556_RS15070	COG0395	ABC-type sugar transport system, permease component
K3556_RS15100	COG1072	(Pantothenic acid kinase))
K3556_RS15110	COG1070	Carbohydrate kinase
K3556_RS15135	COG1175	transmembrane transport
K3556_RS15150	COG2111	Na H antiporter
K3556_RS15150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K3556_RS15155	COG1006	Multisubunit Na H antiporter MnhC subunit
K3556_RS15160	COG0651	ATP synthesis coupled electron transport
K3556_RS15165	COG1863	multisubunit Na H antiporter MnhE subunit
K3556_RS15170	COG2212	antiporter activity
K3556_RS15175	COG1320	monovalent cation:proton antiporter activity
K3556_RS15180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K3556_RS15185	COG1744	ABC transporter substrate-binding protein PnrA-like
K3556_RS15190	COG3845	ABC transporter
K3556_RS15195	COG4603	Belongs to the binding-protein-dependent transport system permease family
K3556_RS15200	COG1079	Belongs to the binding-protein-dependent transport system permease family
K3556_RS15205	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K3556_RS15210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K3556_RS15210	COG0574	Belongs to the PEP-utilizing enzyme family
K3556_RS15220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3556_RS15230	COG4191	Histidine kinase
K3556_RS15230	COG0784	Response regulator, receiver
K3556_RS15255	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3556_RS15260	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3556_RS15260	COG0022	dehydrogenase e1 component
K3556_RS15265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3556_RS15285	COG3273	potassium ion transport
K3556_RS15285	COG0471	metal ion transport
K3556_RS15290	COG1067	ATP-dependent peptidase activity
K3556_RS15300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K3556_RS15310	COG0784	Response regulator, receiver
K3556_RS15310	COG4191	Histidine kinase
K3556_RS15315	COG3243	poly(R)-hydroxyalkanoic acid synthase
K3556_RS15330	COG0189	ligase activity
K3556_RS15330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K3556_RS15335	COG4242	Belongs to the peptidase S51 family
K3556_RS15340	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K3556_RS15345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K3556_RS15365	COG1414	Transcriptional regulator
K3556_RS15375	COG1175	transmembrane transport
K3556_RS15380	COG0395	ABC-type sugar transport system, permease component
K3556_RS15390	COG0129	dihydroxy-acid dehydratase activity
K3556_RS15395	COG1028	Short-chain dehydrogenase reductase Sdr
K3556_RS15400	COG3734	2-keto-3-deoxy-galactonokinase
K3556_RS15405	COG0800	Aldolase
K3556_RS15410	COG3386	PFAM SMP-30 Gluconolaconase
K3556_RS15435	COG1477	protein flavinylation
K3556_RS15440	COG2871	sodium ion transport
K3556_RS15445	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K3556_RS15450	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K3556_RS15455	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K3556_RS15460	COG1805	sodium ion transport
K3556_RS15505	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3556_RS15515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3556_RS15520	COG4166	transmembrane transport
K3556_RS15525	COG0601	transmembrane transport
K3556_RS15530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3556_RS15555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3556_RS15560	COG3938	Belongs to the proline racemase family
K3556_RS15565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3556_RS15575	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K3556_RS15585	COG4786	Flagellar basal body rod
K3556_RS15590	COG4786	Flagellar basal body rod
K3556_RS15595	COG1987	bacterial-type flagellum assembly
K3556_RS15600	COG1677	Flagellar hook-basal body complex protein FliE
K3556_RS15605	COG1558	bacterial-type flagellum-dependent cell motility
K3556_RS15625	COG5443	negative regulation of bacterial-type flagellum assembly
K3556_RS15655	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K3556_RS15670	COG2226	methyltransferase
K3556_RS15675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K3556_RS15680	COG1024	Enoyl-CoA hydratase
K3556_RS15685	COG0268	Binds directly to 16S ribosomal RNA
K3556_RS15695	COG1268	BioY protein
K3556_RS15700	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K3556_RS15705	COG1122	ATPase activity
K3556_RS15715	COG2175	clavaminate synthase activity
K3556_RS15745	COG0738	Major facilitator superfamily
K3556_RS15765	COG0310	cobalt ion transport
K3556_RS15775	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K3556_RS15780	COG1122	ATPase activity
K3556_RS15785	COG4136	ATPase activity
K3556_RS15790	COG4135	transport system, permease component
K3556_RS15795	COG4134	Bacterial extracellular solute-binding protein
K3556_RS15805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K3556_RS15810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K3556_RS15875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K3556_RS15920	COG1215	transferase activity, transferring glycosyl groups
K3556_RS15955	COG3409	Peptidoglycan-binding domain 1 protein
K3556_RS15955	COG3267	Type II secretory pathway component ExeA
K3556_RS15975	COG0705	Rhomboid family
K3556_RS15975	COG0457	Tetratricopeptide repeat
K3556_RS16040	COG4584	PFAM Integrase catalytic
K3556_RS16045	COG1484	DNA-dependent DNA replication
K3556_RS16080	COG3654	unkown
K3556_RS16100	COG4227	nucleotidyltransferase activity
K3556_RS16200	COG0729	surface antigen
K3556_RS16250	COG0300	oxidoreductase activity
K3556_RS16250	COG0318	PFAM AMP-dependent synthetase and ligase
K3556_RS16250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K3556_RS16250	COG1028	Short-chain dehydrogenase reductase Sdr
K3556_RS16250	COG3321	synthase
K3556_RS16285	COG2010	Cytochrome c
K3556_RS16300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K3556_RS16305	COG2010	Cytochrome c
K3556_RS16310	COG3391	amine dehydrogenase activity
K3556_RS16315	COG1522	sequence-specific DNA binding
K3556_RS16330	COG0535	radical SAM domain protein
K3556_RS16350	COG0156	8-amino-7-oxononanoate synthase activity
K3556_RS16375	COG1845	cytochrome c oxidase, subunit III
K3556_RS16385	COG0714	Associated with various cellular activities
K3556_RS16390	COG3256	nitric oxide reductase
K3556_RS16405	COG1028	Short-chain dehydrogenase reductase Sdr
K3556_RS16430	COG3909	cytochrome
K3556_RS16435	COG2010	Cytochrome c