locus-tag	class	description
VSAL_RS00105	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VSAL_RS00110	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VSAL_RS00115	COG0706	membrane insertase activity
VSAL_RS00120	COG0594	ribonuclease P activity
VSAL_RS00125	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VSAL_RS00130	COG1126	abc transporter atp-binding protein
VSAL_RS00145	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VSAL_RS00150	COG0592	DNA-directed DNA polymerase activity
VSAL_RS00155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VSAL_RS00160	COG0187	DNA topoisomerase II activity
VSAL_RS00170	COG4372	Transposase
VSAL_RS00190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VSAL_RS00290	COG0840	transmembrane signaling receptor activity
VSAL_RS00320	COG0606	chelatase, subunit chli
VSAL_RS00325	COG0204	Acyl-transferase
VSAL_RS00330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VSAL_RS00335	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VSAL_RS00345	COG3084	Protein conserved in bacteria
VSAL_RS00355	COG1272	protein, Hemolysin III
VSAL_RS00365	COG1278	Cold shock
VSAL_RS00380	COG3978	acetolactate synthase activity
VSAL_RS00400	COG1192	Involved in chromosome partitioning
VSAL_RS00470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VSAL_RS00475	COG0569	domain protein
VSAL_RS00480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VSAL_RS00480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VSAL_RS00490	COG0242	peptide deformylase activity
VSAL_RS00495	COG1652	LysM domain
VSAL_RS00500	COG0758	DNA mediated transformation
VSAL_RS00505	COG2922	Belongs to the Smg family
VSAL_RS00510	COG0551	DNA topoisomerase type I activity
VSAL_RS00515	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VSAL_RS00520	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VSAL_RS00525	COG0009	L-threonylcarbamoyladenylate synthase
VSAL_RS00530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VSAL_RS00540	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VSAL_RS00675	COG0583	DNA-binding transcription factor activity
VSAL_RS00680	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VSAL_RS00685	COG2960	long-chain fatty acid transporting porin activity
VSAL_RS00690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VSAL_RS00695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSAL_RS00700	COG1309	transcriptional regulator
VSAL_RS00705	COG0210	DNA helicase
VSAL_RS00750	COG0601	transmembrane transport
VSAL_RS00755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VSAL_RS00760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VSAL_RS00770	COG0517	IMP dehydrogenase activity
VSAL_RS00785	COG3711	transcriptional antiterminator
VSAL_RS00785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSAL_RS00800	COG3964	amidohydrolase
VSAL_RS00845	COG4372	Transposase
VSAL_RS00860	COG0515	serine threonine protein kinase
VSAL_RS00860	COG2815	serine threonine protein kinase
VSAL_RS00870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VSAL_RS00875	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VSAL_RS00890	COG1965	Belongs to the frataxin family
VSAL_RS00895	COG0019	diaminopimelate decarboxylase activity
VSAL_RS00900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VSAL_RS00910	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VSAL_RS00940	COG0076	glutamate decarboxylase activity
VSAL_RS00945	COG3486	L-lysine 6-monooxygenase (NADPH) activity
VSAL_RS00960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VSAL_RS00965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VSAL_RS00970	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VSAL_RS00990	COG4372	Transposase
VSAL_RS01000	COG0513	Belongs to the DEAD box helicase family
VSAL_RS01005	COG3118	belongs to the thioredoxin family
VSAL_RS01020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VSAL_RS01050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VSAL_RS01055	COG1368	sulfuric ester hydrolase activity
VSAL_RS01060	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VSAL_RS01080	COG1519	Transferase
VSAL_RS01115	COG2089	acid synthase
VSAL_RS01120	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VSAL_RS01125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VSAL_RS01140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VSAL_RS01170	COG1088	dTDP-glucose 4,6-dehydratase activity
VSAL_RS01175	COG3083	sulfuric ester hydrolase activity
VSAL_RS01180	COG3642	lipopolysaccharide core region biosynthetic process
VSAL_RS01185	COG0859	PFAM glycosyl transferase family 9
VSAL_RS01190	COG0463	Glycosyl transferase, family 2
VSAL_RS01195	COG0438	transferase activity, transferring glycosyl groups
VSAL_RS01200	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VSAL_RS01205	COG1368	sulfuric ester hydrolase activity
VSAL_RS01210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VSAL_RS01220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VSAL_RS01225	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VSAL_RS01230	COG2003	Belongs to the UPF0758 family
VSAL_RS01235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VSAL_RS01245	COG1560	Kdo2-lipid A biosynthetic process
VSAL_RS01250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VSAL_RS01255	COG2183	response to ionizing radiation
VSAL_RS01265	COG2267	carboxylic ester hydrolase activity
VSAL_RS01275	COG1040	competence protein
VSAL_RS01305	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VSAL_RS01310	COG1561	YicC-like family, N-terminal region
VSAL_RS01320	COG0194	GDP metabolic process
VSAL_RS01325	COG1758	RNA polymerase activity
VSAL_RS01330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VSAL_RS01335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VSAL_RS01340	COG4372	Transposase
VSAL_RS01355	COG3071	HemY protein
VSAL_RS01360	COG2959	enzyme of heme biosynthesis
VSAL_RS01365	COG1587	Uroporphyrinogen-III synthase
VSAL_RS01370	COG0181	hydroxymethylbilane synthase activity
VSAL_RS01380	COG0210	DNA helicase
VSAL_RS01385	COG2962	Rard protein
VSAL_RS01390	COG0514	ATP-dependent DNA helicase (RecQ)
VSAL_RS01400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VSAL_RS01405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VSAL_RS01405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VSAL_RS01410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VSAL_RS01425	COG3078	GTPase activator activity
VSAL_RS01450	COG4372	Transposase
VSAL_RS01455	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VSAL_RS01460	COG0438	transferase activity, transferring glycosyl groups
VSAL_RS01465	COG0463	Glycosyl transferase, family 2
VSAL_RS01470	COG0859	PFAM glycosyl transferase family 9
VSAL_RS01475	COG3642	lipopolysaccharide core region biosynthetic process
VSAL_RS01480	COG3083	sulfuric ester hydrolase activity
VSAL_RS01485	COG1088	dTDP-glucose 4,6-dehydratase activity
VSAL_RS01515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VSAL_RS01530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VSAL_RS01535	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VSAL_RS01540	COG2089	acid synthase
VSAL_RS01575	COG1519	Transferase
VSAL_RS01595	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VSAL_RS01630	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSAL_RS01660	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
VSAL_RS01660	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
VSAL_RS01680	COG2852	Protein conserved in bacteria
VSAL_RS01685	COG0149	triose-phosphate isomerase activity
VSAL_RS01705	COG1494	fructose-1,6-bisphosphatase
VSAL_RS01710	COG3074	FtsZ-dependent cytokinesis
VSAL_RS01725	COG4372	Transposase
VSAL_RS01730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VSAL_RS01735	COG1575	Belongs to the MenA family. Type 1 subfamily
VSAL_RS01740	COG3954	Phosphoribulokinase
VSAL_RS01745	COG3089	Belongs to the UPF0270 family
VSAL_RS01750	COG0429	hydrolase of the alpha beta-hydrolase fold
VSAL_RS01760	COG0488	(ABC) transporter
VSAL_RS01765	COG2249	NAD(P)H dehydrogenase (quinone) activity
VSAL_RS01780	COG1047	Peptidyl-prolyl cis-trans
VSAL_RS01785	COG2900	Belongs to the SlyX family
VSAL_RS01795	COG0545	Peptidyl-prolyl cis-trans isomerase
VSAL_RS01800	COG2964	Protein conserved in bacteria
VSAL_RS01805	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VSAL_RS01810	COG2923	Belongs to the DsrF TusC family
VSAL_RS01820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VSAL_RS01825	COG0049	tRNA binding
VSAL_RS01830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VSAL_RS01875	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VSAL_RS01880	COG0088	Forms part of the polypeptide exit tunnel
VSAL_RS01885	COG0089	rRNA binding
VSAL_RS01890	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VSAL_RS01895	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VSAL_RS01900	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VSAL_RS01905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VSAL_RS01910	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VSAL_RS01920	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VSAL_RS01925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VSAL_RS01930	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VSAL_RS01935	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VSAL_RS01940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VSAL_RS01945	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VSAL_RS01950	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VSAL_RS01955	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VSAL_RS01960	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VSAL_RS01965	COG1841	ribosomal large subunit assembly
VSAL_RS01970	COG0200	Binds to the 23S rRNA
VSAL_RS01975	COG0201	protein transport
VSAL_RS01985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VSAL_RS01995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VSAL_RS02000	COG0202	RNA polymerase activity
VSAL_RS02005	COG0203	ribosomal protein L17
VSAL_RS02010	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VSAL_RS02015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VSAL_RS02020	COG0163	prenyltransferase activity
VSAL_RS02025	COG4143	(ABC) transporter
VSAL_RS02030	COG1178	ABC-type Fe3 transport system permease component
VSAL_RS02035	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VSAL_RS02040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VSAL_RS02045	COG0564	pseudouridine synthase activity
VSAL_RS02050	COG0589	response to stress
VSAL_RS02070	COG1438	arginine binding
VSAL_RS02075	COG0039	L-malate dehydrogenase activity
VSAL_RS02080	COG0142	geranyltranstransferase activity
VSAL_RS02085	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VSAL_RS02090	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VSAL_RS02095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VSAL_RS02100	COG2966	Psort location CytoplasmicMembrane, score
VSAL_RS02105	COG3610	response to peptide
VSAL_RS02115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VSAL_RS02120	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VSAL_RS02125	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VSAL_RS02130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VSAL_RS02135	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VSAL_RS02140	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VSAL_RS02150	COG0066	3-isopropylmalate dehydratase activity
VSAL_RS02155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VSAL_RS02160	COG0473	3-isopropylmalate dehydrogenase activity
VSAL_RS02165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VSAL_RS02180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VSAL_RS02190	COG0305	Participates in initiation and elongation during chromosome replication
VSAL_RS02195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VSAL_RS02205	COG0166	Belongs to the GPI family
VSAL_RS02215	COG0735	belongs to the Fur family
VSAL_RS02235	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VSAL_RS02270	COG0582	viral genome integration into host DNA
VSAL_RS02290	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VSAL_RS02295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VSAL_RS02300	COG0175	sulfate reduction
VSAL_RS02310	COG0545	Peptidyl-prolyl cis-trans isomerase
VSAL_RS02315	COG3266	domain, Protein
VSAL_RS02315	COG3061	Opacity-associated protein A
VSAL_RS02325	COG2153	protein acetylation
VSAL_RS02375	COG0737	Belongs to the 5'-nucleotidase family
VSAL_RS02380	COG0175	sulfate reduction
VSAL_RS02385	COG2895	sulfate adenylyltransferase (ATP) activity
VSAL_RS02390	COG3273	potassium ion transport
VSAL_RS02390	COG0471	metal ion transport
VSAL_RS02395	COG0529	Catalyzes the synthesis of activated sulfate
VSAL_RS02410	COG0577	efflux transmembrane transporter activity
VSAL_RS02415	COG1136	(ABC) transporter
VSAL_RS02425	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VSAL_RS02435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VSAL_RS02440	COG0729	surface antigen
VSAL_RS02445	COG2911	Protein conserved in bacteria
VSAL_RS02505	COG4372	Transposase
VSAL_RS02540	COG0527	aspartate kinase activity
VSAL_RS02545	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VSAL_RS02555	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VSAL_RS02570	COG0438	transferase activity, transferring glycosyl groups
VSAL_RS02570	COG0297	glycogen (starch) synthase activity
VSAL_RS02575	COG0438	transferase activity, transferring glycosyl groups
VSAL_RS02630	COG0629	single-stranded DNA binding
VSAL_RS02650	COG2200	EAL domain
VSAL_RS02650	COG2199	diguanylate cyclase activity
VSAL_RS02675	COG3267	Type II secretory pathway component ExeA
VSAL_RS02675	COG3409	Peptidoglycan-binding domain 1 protein
VSAL_RS02690	COG1459	type II secretion system
VSAL_RS02700	COG2165	general secretion pathway protein
VSAL_RS02705	COG2165	general secretion pathway protein
VSAL_RS02710	COG2165	general secretion pathway protein
VSAL_RS02745	COG1077	Cell shape determining protein MreB Mrl
VSAL_RS02750	COG1792	Involved in formation and maintenance of cell shape
VSAL_RS02755	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VSAL_RS02760	COG0424	maF-like protein
VSAL_RS02765	COG1530	ribonuclease E activity
VSAL_RS02770	COG3164	Protein of unknown function
VSAL_RS02780	COG0312	modulator of DNA gyrase
VSAL_RS02790	COG0312	modulator of DNA gyrase
VSAL_RS02795	COG2239	Acts as a magnesium transporter
VSAL_RS02800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSAL_RS02805	COG1660	Displays ATPase and GTPase activities
VSAL_RS02825	COG1137	ATPase activity
VSAL_RS02830	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VSAL_RS02840	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VSAL_RS02845	COG0517	IMP dehydrogenase activity
VSAL_RS02845	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VSAL_RS02855	COG1127	ABC transporter
VSAL_RS02860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VSAL_RS02865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VSAL_RS02870	COG2854	intermembrane phospholipid transfer
VSAL_RS02880	COG5007	Belongs to the BolA IbaG family
VSAL_RS02885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VSAL_RS02920	COG0251	oxidation-reduction process
VSAL_RS02925	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VSAL_RS02930	COG0540	Belongs to the ATCase OTCase family
VSAL_RS02935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VSAL_RS02940	COG2235	arginine
VSAL_RS02955	COG0525	valine-tRNA ligase activity
VSAL_RS02960	COG2927	DNA polymerase III (CHI subunit)
VSAL_RS02965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VSAL_RS02970	COG0795	lipopolysaccharide-transporting ATPase activity
VSAL_RS02975	COG0795	lipopolysaccharide-transporting ATPase activity
VSAL_RS02995	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VSAL_RS03035	COG0741	lytic transglycosylase activity
VSAL_RS03040	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VSAL_RS03045	COG1194	a g-specific adenine glycosylase
VSAL_RS03050	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VSAL_RS03055	COG2066	Belongs to the glutaminase family
VSAL_RS03060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VSAL_RS03065	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VSAL_RS03080	COG0762	integral membrane protein
VSAL_RS03085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VSAL_RS03090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VSAL_RS03105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VSAL_RS03110	COG1678	Uncharacterized ACR, COG1678
VSAL_RS03115	COG0189	ligase activity
VSAL_RS03120	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VSAL_RS03125	COG2356	endonuclease I
VSAL_RS03130	COG3091	SprT-like family
VSAL_RS03135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VSAL_RS03140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VSAL_RS03145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VSAL_RS03150	COG0126	phosphoglycerate kinase activity
VSAL_RS03155	COG0191	fructose-bisphosphate aldolase activity
VSAL_RS03160	COG0513	Belongs to the DEAD box helicase family
VSAL_RS03165	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VSAL_RS03175	COG0716	FMN binding
VSAL_RS03180	COG4974	Belongs to the 'phage' integrase family
VSAL_RS03190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VSAL_RS03195	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VSAL_RS03200	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VSAL_RS03205	COG2204	response regulator
VSAL_RS03210	COG3066	DNA modification
VSAL_RS03215	COG0494	nUDIX hydrolase
VSAL_RS03225	COG0730	response to heat
VSAL_RS03230	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VSAL_RS03235	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VSAL_RS03240	COG1283	sodium-dependent phosphate transmembrane transporter activity
VSAL_RS03245	COG0583	DNA-binding transcription factor activity
VSAL_RS03250	COG0640	Transcriptional regulator
VSAL_RS03255	COG0268	Binds directly to 16S ribosomal RNA
VSAL_RS03260	COG0728	peptidoglycan biosynthetic process
VSAL_RS03265	COG0196	riboflavin kinase activity
VSAL_RS03270	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VSAL_RS03275	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VSAL_RS03280	COG1047	Peptidyl-prolyl cis-trans
VSAL_RS03285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VSAL_RS03290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VSAL_RS03295	COG0505	Belongs to the CarA family
VSAL_RS03300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VSAL_RS03305	COG2027	D-alanyl-D-alanine carboxypeptidase
VSAL_RS03310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VSAL_RS03315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VSAL_RS03320	COG1534	Rna-binding protein
VSAL_RS03325	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VSAL_RS03330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VSAL_RS03335	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VSAL_RS03340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VSAL_RS03345	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VSAL_RS03360	COG0779	Required for maturation of 30S ribosomal subunits
VSAL_RS03365	COG0195	Participates in both transcription termination and antitermination
VSAL_RS03370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VSAL_RS03375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VSAL_RS03380	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VSAL_RS03385	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VSAL_RS03390	COG1185	polyribonucleotide nucleotidyltransferase activity
VSAL_RS03400	COG0826	peptidase U32
VSAL_RS03405	COG0826	peptidase U32
VSAL_RS03415	COG3154	lipid carrier protein
VSAL_RS03435	COG0456	acetyltransferase
VSAL_RS03440	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VSAL_RS03445	COG0084	hydrolase, TatD family'
VSAL_RS03450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VSAL_RS03455	COG3385	transposase activity
VSAL_RS03465	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VSAL_RS03470	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VSAL_RS03475	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VSAL_RS03490	COG0560	Phosphoserine phosphatase
VSAL_RS03500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VSAL_RS03505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VSAL_RS03510	COG4628	conserved protein (DUF2132)
VSAL_RS03515	COG0402	S-adenosylhomocysteine deaminase activity
VSAL_RS03520	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VSAL_RS03525	COG1022	Amp-dependent synthetase and ligase
VSAL_RS03530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VSAL_RS03535	COG1546	Belongs to the CinA family
VSAL_RS03540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VSAL_RS03545	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VSAL_RS03555	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VSAL_RS03600	COG3630	sodium ion export across plasma membrane
VSAL_RS03605	COG0511	ligase activity, forming carbon-carbon bonds
VSAL_RS03605	COG5016	pyruvate
VSAL_RS03610	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VSAL_RS03615	COG1238	metal cluster binding
VSAL_RS03620	COG0612	Peptidase, M16
VSAL_RS03625	COG2918	glutathione biosynthetic process
VSAL_RS03635	COG1854	S-ribosylhomocysteine lyase activity
VSAL_RS03640	COG4536	flavin adenine dinucleotide binding
VSAL_RS03645	COG4137	Cytochrome C assembly protein
VSAL_RS03650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VSAL_RS03660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VSAL_RS03665	COG0336	Belongs to the RNA methyltransferase TrmD family
VSAL_RS03670	COG0335	large ribosomal subunit rRNA binding
VSAL_RS03680	COG1605	Chorismate mutase
VSAL_RS03680	COG0287	Prephenate dehydrogenase
VSAL_RS03685	COG0739	heme binding
VSAL_RS03705	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VSAL_RS03715	COG1605	Chorismate mutase
VSAL_RS03715	COG0077	Prephenate dehydratase
VSAL_RS03720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VSAL_RS03725	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSAL_RS03730	COG0564	pseudouridine synthase activity
VSAL_RS03735	COG1496	oxidoreductase activity
VSAL_RS03740	COG0542	response to heat
VSAL_RS03800	COG2059	Chromate
VSAL_RS03805	COG0583	DNA-binding transcription factor activity
VSAL_RS03815	COG2171	N-acyltransferase activity
VSAL_RS03820	COG3141	response to X-ray
VSAL_RS03830	COG0583	DNA-binding transcription factor activity
VSAL_RS03840	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VSAL_RS03845	COG1074	ATP-dependent DNA helicase activity
VSAL_RS03850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VSAL_RS03855	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VSAL_RS03860	COG0165	Argininosuccinate lyase
VSAL_RS03865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VSAL_RS03865	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VSAL_RS03875	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VSAL_RS03880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VSAL_RS03885	COG2166	iron-sulfur cluster assembly
VSAL_RS03890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VSAL_RS03895	COG0583	DNA-binding transcription factor activity
VSAL_RS03900	COG2363	Small membrane protein
VSAL_RS03905	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VSAL_RS03910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VSAL_RS03915	COG1611	Belongs to the LOG family
VSAL_RS03930	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VSAL_RS03930	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VSAL_RS03940	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VSAL_RS03945	COG1671	Belongs to the UPF0178 family
VSAL_RS03960	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VSAL_RS03965	COG2723	6-phospho-beta-galactosidase activity
VSAL_RS03970	COG1940	carbohydrate kinase activity
VSAL_RS03975	COG1447	Phosphotransferase system cellobiose-specific component IIA
VSAL_RS03980	COG1609	Transcriptional regulator
VSAL_RS04005	COG0564	pseudouridine synthase activity
VSAL_RS04010	COG0483	inositol monophosphate 1-phosphatase activity
VSAL_RS04020	COG1959	2 iron, 2 sulfur cluster binding
VSAL_RS04030	COG0822	iron-sulfur transferase activity
VSAL_RS04035	COG0316	Belongs to the HesB IscA family
VSAL_RS04040	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VSAL_RS04045	COG0443	Heat shock 70 kDa protein
VSAL_RS04050	COG0633	Ferredoxin
VSAL_RS04055	COG2975	iron-sulfur cluster assembly
VSAL_RS04060	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VSAL_RS04065	COG0105	UTP biosynthetic process
VSAL_RS04070	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VSAL_RS04085	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VSAL_RS04095	COG2976	Protein conserved in bacteria
VSAL_RS04100	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSAL_RS04105	COG1160	GTP binding
VSAL_RS04120	COG1570	exodeoxyribonuclease VII activity
VSAL_RS04125	COG0517	IMP dehydrogenase activity
VSAL_RS04125	COG0516	GMP reductase activity
VSAL_RS04130	COG0519	Catalyzes the synthesis of GMP from XMP
VSAL_RS04130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VSAL_RS04135	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VSAL_RS04140	COG2964	Protein conserved in bacteria
VSAL_RS04145	COG3681	Belongs to the UPF0597 family
VSAL_RS04150	COG0251	oxidation-reduction process
VSAL_RS04155	COG0814	amino acid
VSAL_RS04170	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VSAL_RS04185	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VSAL_RS04190	COG0047	phosphoribosylformylglycinamidine synthase activity
VSAL_RS04190	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VSAL_RS04200	COG2991	Protein conserved in bacteria
VSAL_RS04205	COG1342	Belongs to the UPF0251 family
VSAL_RS04225	COG3469	chitinase activity
VSAL_RS04225	COG3325	Belongs to the glycosyl hydrolase 18 family
VSAL_RS04230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VSAL_RS04240	COG0189	ligase activity
VSAL_RS04245	COG0189	ligase activity
VSAL_RS04245	COG4067	protein conserved in archaea
VSAL_RS04250	COG0733	neurotransmitter:sodium symporter activity
VSAL_RS04255	COG3397	chitin binding
VSAL_RS04320	COG3023	N-Acetylmuramoyl-L-alanine amidase
VSAL_RS04350	COG4372	Transposase
VSAL_RS04410	COG0012	GTP binding
VSAL_RS04415	COG0193	aminoacyl-tRNA hydrolase activity
VSAL_RS04420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VSAL_RS04425	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VSAL_RS04430	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VSAL_RS04435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VSAL_RS04440	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VSAL_RS04445	COG2890	protein-(glutamine-N5) methyltransferase activity
VSAL_RS04450	COG3094	Invasion gene expression up-regulator, SirB
VSAL_RS04455	COG2912	Transglutaminase-like superfamily
VSAL_RS04460	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VSAL_RS04465	COG1648	precorrin-2 dehydrogenase activity
VSAL_RS04465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VSAL_RS04480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VSAL_RS04505	COG2608	mercury ion transmembrane transporter activity
VSAL_RS04505	COG2217	Heavy metal translocating P-type atpase
VSAL_RS04510	COG0789	Transcriptional regulator
VSAL_RS04515	COG3118	belongs to the thioredoxin family
VSAL_RS04520	COG0300	oxidoreductase activity
VSAL_RS04525	COG1090	epimerase
VSAL_RS04530	COG0622	Phosphoesterase
VSAL_RS04535	COG3385	transposase activity
VSAL_RS04550	COG4372	Transposase
VSAL_RS04555	COG3385	transposase activity
VSAL_RS04565	COG3710	Transcriptional regulator
VSAL_RS04570	COG0326	Molecular chaperone. Has ATPase activity
VSAL_RS04575	COG0563	adenylate kinase activity
VSAL_RS04580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VSAL_RS04585	COG0544	peptidyl-prolyl cis-trans isomerase activity
VSAL_RS04590	COG0740	serine-type endopeptidase activity
VSAL_RS04610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VSAL_RS04615	COG0776	regulation of translation
VSAL_RS04620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VSAL_RS04625	COG1596	polysaccharide export
VSAL_RS04625	COG1555	photosystem II stabilization
VSAL_RS04630	COG3104	oligopeptide transport
VSAL_RS04635	COG0250	Participates in transcription elongation, termination and antitermination
VSAL_RS04640	COG0367	asparagine synthase
VSAL_RS04645	COG4651	solute:proton antiporter activity
VSAL_RS04645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VSAL_RS04650	COG1940	carbohydrate kinase activity
VSAL_RS04650	COG1846	Transcriptional regulator
VSAL_RS04655	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VSAL_RS04660	COG1263	PTS System
VSAL_RS04660	COG2190	(PTS) system
VSAL_RS04660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSAL_RS04665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VSAL_RS04670	COG0735	belongs to the Fur family
VSAL_RS04690	COG0596	Alpha beta hydrolase
VSAL_RS04695	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VSAL_RS04700	COG0033	Phosphoglucomutase
VSAL_RS04705	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VSAL_RS04710	COG0372	Belongs to the citrate synthase family
VSAL_RS04720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VSAL_RS04725	COG1053	succinate dehydrogenase
VSAL_RS04735	COG0567	Dehydrogenase, E1 component
VSAL_RS04740	COG0508	dehydrogenase complex catalyzes the overall conversion of
VSAL_RS04745	COG0045	succinate-CoA ligase (ADP-forming) activity
VSAL_RS04755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VSAL_RS04760	COG1121	(ABC) transporter
VSAL_RS04765	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VSAL_RS04770	COG0739	heme binding
VSAL_RS04780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VSAL_RS04785	COG1032	radical SAM domain protein
VSAL_RS04790	COG3069	C4-dicarboxylate transmembrane transporter activity
VSAL_RS04805	COG0583	DNA-binding transcription factor activity
VSAL_RS04820	COG3064	Membrane
VSAL_RS04825	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VSAL_RS04845	COG0444	Belongs to the ABC transporter superfamily
VSAL_RS04850	COG0747	negative chemotaxis
VSAL_RS04855	COG4239	(ABC) transporter, permease
VSAL_RS04860	COG4174	ABC transporter (Permease)
VSAL_RS04875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VSAL_RS04885	COG1012	belongs to the aldehyde dehydrogenase family
VSAL_RS04895	COG0583	DNA-binding transcription factor activity
VSAL_RS04925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VSAL_RS04930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VSAL_RS04935	COG2011	ABC-type metal ion transport system permease component
VSAL_RS04940	COG1464	Belongs to the NlpA lipoprotein family
VSAL_RS04945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VSAL_RS04950	COG0254	rRNA binding
VSAL_RS04955	COG1720	tRNA m6t6A37 methyltransferase activity
VSAL_RS04960	COG0442	prolyl-tRNA aminoacylation
VSAL_RS04965	COG2731	YhcH YjgK YiaL family protein
VSAL_RS04970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VSAL_RS04990	COG1737	Transcriptional regulator
VSAL_RS04995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VSAL_RS05010	COG3469	chitinase activity
VSAL_RS05030	COG0318	PFAM AMP-dependent synthetase and ligase
VSAL_RS05050	COG1214	PFAM Peptidase M22, glycoprotease
VSAL_RS05055	COG1199	ATP-dependent helicase activity
VSAL_RS05060	COG0788	formyltetrahydrofolate deformylase activity
VSAL_RS05065	COG0596	Alpha beta hydrolase
VSAL_RS05095	COG0840	transmembrane signaling receptor activity
VSAL_RS05100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VSAL_RS05105	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VSAL_RS05105	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VSAL_RS05120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VSAL_RS05125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VSAL_RS05130	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VSAL_RS05135	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VSAL_RS05145	COG2205	protein histidine kinase activity
VSAL_RS05145	COG0784	Response regulator, receiver
VSAL_RS05160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VSAL_RS05165	COG0142	geranyltranstransferase activity
VSAL_RS05170	COG1722	exodeoxyribonuclease VII activity
VSAL_RS05175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VSAL_RS05185	COG0301	tRNA thio-modification
VSAL_RS05185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VSAL_RS05200	COG0693	protein deglycase activity
VSAL_RS05205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VSAL_RS05215	COG2807	transmembrane transport
VSAL_RS05220	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VSAL_RS05230	COG2813	Specifically methylates the guanine in position
VSAL_RS05235	COG0271	Belongs to the BolA IbaG family
VSAL_RS05240	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VSAL_RS05245	COG1805	sodium ion transport
VSAL_RS05255	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VSAL_RS05260	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VSAL_RS05265	COG2871	sodium ion transport
VSAL_RS05270	COG1477	protein flavinylation
VSAL_RS05275	COG2991	Protein conserved in bacteria
VSAL_RS05280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VSAL_RS05325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VSAL_RS05350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VSAL_RS05360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VSAL_RS05365	COG2195	Cleaves the N-terminal amino acid of tripeptides
VSAL_RS05370	COG2252	PERMEase
VSAL_RS05375	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VSAL_RS05380	COG1073	alpha beta
VSAL_RS05385	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VSAL_RS05390	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VSAL_RS05395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VSAL_RS05400	COG0321	lipoyl(octanoyl) transferase activity
VSAL_RS05405	COG2921	Belongs to the UPF0250 family
VSAL_RS05410	COG1686	Belongs to the peptidase S11 family
VSAL_RS05415	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VSAL_RS05420	COG0772	Belongs to the SEDS family
VSAL_RS05425	COG0768	penicillin binding
VSAL_RS05430	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VSAL_RS05435	COG0799	negative regulation of ribosome biogenesis
VSAL_RS05440	COG1466	dna polymerase III delta subunit
VSAL_RS05450	COG0495	leucyl-tRNA aminoacylation
VSAL_RS05455	COG2888	peptidyl-tyrosine sulfation
VSAL_RS05460	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VSAL_RS05465	COG4535	Mg2 and Co2 transporter CorC
VSAL_RS05470	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VSAL_RS05475	COG1702	phosphate starvation-inducible protein PhoH
VSAL_RS05480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VSAL_RS05485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VSAL_RS05500	COG4372	Transposase
VSAL_RS05540	COG4974	Belongs to the 'phage' integrase family
VSAL_RS05625	COG4695	Portal protein
VSAL_RS05780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VSAL_RS05805	COG3083	sulfuric ester hydrolase activity
VSAL_RS05810	COG3082	Protein of unknown function (DUF1414)
VSAL_RS05815	COG3081	Nucleoid-associated protein
VSAL_RS05825	COG4372	Transposase
VSAL_RS05835	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VSAL_RS05840	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VSAL_RS05845	COG2894	cell division
VSAL_RS05850	COG0850	regulation of cytokinetic process
VSAL_RS05855	COG3100	YcgL domain-containing protein
VSAL_RS05860	COG2951	lytic endotransglycosylase activity
VSAL_RS05865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VSAL_RS05865	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VSAL_RS05870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VSAL_RS05875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VSAL_RS05880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VSAL_RS05895	COG0101	tRNA pseudouridine synthase activity
VSAL_RS05905	COG0285	dihydrofolate synthase activity
VSAL_RS05910	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VSAL_RS05915	COG1286	toxin biosynthetic process
VSAL_RS05920	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VSAL_RS05925	COG0583	DNA-binding transcription factor activity
VSAL_RS05930	COG0745	RESPONSE REGULATOR receiver
VSAL_RS05935	COG2832	Protein of unknown function (DUF454)
VSAL_RS05940	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VSAL_RS05945	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VSAL_RS05950	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VSAL_RS05955	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VSAL_RS05980	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VSAL_RS05990	COG0697	spore germination
VSAL_RS05995	COG1979	alcohol dehydrogenase
VSAL_RS06000	COG2207	Transcriptional regulator
VSAL_RS06005	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VSAL_RS06010	COG0436	Aminotransferase
VSAL_RS06015	COG1169	isochorismate synthase
VSAL_RS06020	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VSAL_RS06030	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VSAL_RS06035	COG1441	menaquinone biosynthetic process
VSAL_RS06160	COG3923	Primosomal replication protein n
VSAL_RS06165	COG0730	response to heat
VSAL_RS06170	COG1199	ATP-dependent helicase activity
VSAL_RS06180	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VSAL_RS06190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VSAL_RS06195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VSAL_RS06200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VSAL_RS06205	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VSAL_RS06205	COG0131	Imidazoleglycerol-phosphate dehydratase
VSAL_RS06210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VSAL_RS06215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VSAL_RS06220	COG0107	imidazoleglycerol-phosphate synthase activity
VSAL_RS06225	COG0140	phosphoribosyl-ATP diphosphatase activity
VSAL_RS06225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VSAL_RS06235	COG0564	pseudouridine synthase activity
VSAL_RS06240	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VSAL_RS06240	COG0116	Belongs to the methyltransferase superfamily
VSAL_RS06250	COG2350	Protein conserved in bacteria
VSAL_RS06260	COG2917	probably involved in intracellular septation
VSAL_RS06270	COG0159	tryptophan synthase activity
VSAL_RS06275	COG0133	tryptophan synthase activity
VSAL_RS06280	COG0135	phosphoribosylanthranilate isomerase activity
VSAL_RS06280	COG0134	indole-3-glycerol-phosphate synthase activity
VSAL_RS06285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VSAL_RS06290	COG0512	Glutamine amidotransferase of anthranilate synthase
VSAL_RS06295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VSAL_RS06300	COG0613	PHP domain protein
VSAL_RS06305	COG0009	L-threonylcarbamoyladenylate synthase
VSAL_RS06320	COG1187	pseudouridine synthase activity
VSAL_RS06325	COG1028	Short-chain dehydrogenase reductase Sdr
VSAL_RS06330	COG0616	signal peptide processing
VSAL_RS06340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VSAL_RS06345	COG0471	metal ion transport
VSAL_RS06435	COG3385	transposase activity
VSAL_RS06450	COG1280	lysine exporter protein (LysE YggA)
VSAL_RS06455	COG2207	Transcriptional regulator
VSAL_RS06455	COG1917	Cupin 2, conserved barrel domain protein
VSAL_RS06470	COG0179	Fumarylacetoacetate (FAA) hydrolase
VSAL_RS06485	COG2195	Cleaves the N-terminal amino acid of tripeptides
VSAL_RS06490	COG3069	C4-dicarboxylate transmembrane transporter activity
VSAL_RS06495	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VSAL_RS06505	COG0076	glutamate decarboxylase activity
VSAL_RS06510	COG2985	domain, Protein
VSAL_RS06515	COG0583	DNA-binding transcription factor activity
VSAL_RS06520	COG1741	Belongs to the pirin family
VSAL_RS06525	COG0435	Glutathione S-transferase
VSAL_RS06540	COG4667	esterase of the alpha-beta hydrolase superfamily
VSAL_RS06545	COG4372	Transposase
VSAL_RS06570	COG0673	inositol 2-dehydrogenase activity
VSAL_RS06575	COG4533	DNA binding
VSAL_RS06600	COG3655	Transcriptional regulator
VSAL_RS06655	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VSAL_RS06665	COG2358	TRAP transporter, solute receptor (TAXI family
VSAL_RS06685	COG0583	DNA-binding transcription factor activity
VSAL_RS06690	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VSAL_RS06700	COG1404	Belongs to the peptidase S8 family
VSAL_RS06720	COG1309	transcriptional regulator
VSAL_RS06730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VSAL_RS06770	COG0583	DNA-binding transcription factor activity
VSAL_RS06780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VSAL_RS06785	COG0484	heat shock protein binding
VSAL_RS06810	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VSAL_RS06820	COG4681	YaeQ
VSAL_RS06830	COG0583	DNA-binding transcription factor activity
VSAL_RS06875	COG2949	membrane
VSAL_RS06885	COG0281	malic enzyme
VSAL_RS06890	COG1643	Atp-dependent helicase
VSAL_RS06915	COG4372	Transposase
VSAL_RS06920	COG1301	dicarboxylic acid transport
VSAL_RS06925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VSAL_RS06960	COG0366	Alpha amylase catalytic
VSAL_RS06980	COG4372	Transposase
VSAL_RS06985	COG0840	transmembrane signaling receptor activity
VSAL_RS06990	COG0537	adenosine 5'-monophosphoramidase activity
VSAL_RS07025	COG2226	methyltransferase
VSAL_RS07035	COG2084	Dehydrogenase
VSAL_RS07040	COG2175	clavaminate synthase activity
VSAL_RS07045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VSAL_RS07070	COG1252	NADH dehydrogenase
VSAL_RS07075	COG0513	Belongs to the DEAD box helicase family
VSAL_RS07105	COG3279	Response regulator of the LytR AlgR family
VSAL_RS07110	COG3275	phosphorelay sensor kinase activity
VSAL_RS07115	COG1584	GPR1 FUN34 yaaH family protein
VSAL_RS07120	COG0501	Belongs to the peptidase M48B family
VSAL_RS07135	COG1301	dicarboxylic acid transport
VSAL_RS07140	COG0402	S-adenosylhomocysteine deaminase activity
VSAL_RS07145	COG2989	Protein conserved in bacteria
VSAL_RS07150	COG3108	Peptidase M15
VSAL_RS07155	COG0017	Asparaginyl-tRNA synthetase
VSAL_RS07160	COG0720	synthase
VSAL_RS07170	COG0420	3'-5' exonuclease activity
VSAL_RS07175	COG0419	ATPase involved in DNA repair
VSAL_RS07195	COG0814	amino acid
VSAL_RS07200	COG0814	amino acid
VSAL_RS07225	COG1760	l-serine dehydratase
VSAL_RS07230	COG0814	amino acid
VSAL_RS07255	COG3385	transposase activity
VSAL_RS07270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSAL_RS07285	COG0626	cystathionine gamma-synthase activity
VSAL_RS07300	COG3501	Rhs element vgr protein
VSAL_RS07340	COG1793	dna ligase
VSAL_RS07345	COG1609	Transcriptional regulator
VSAL_RS07350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VSAL_RS07355	COG1879	ABC-type sugar transport system periplasmic component
VSAL_RS07360	COG1172	Belongs to the binding-protein-dependent transport system permease family
VSAL_RS07365	COG1129	ABC transporter
VSAL_RS07370	COG1869	D-ribose catabolic process
VSAL_RS07415	COG0534	Mate efflux family protein
VSAL_RS07420	COG0307	riboflavin synthase, alpha
VSAL_RS07430	COG3001	Fructosamine kinase
VSAL_RS07440	COG0791	NLP P60 protein
VSAL_RS07445	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VSAL_RS07450	COG1187	pseudouridine synthase activity
VSAL_RS07460	COG3148	PFAM DTW domain containing protein
VSAL_RS07465	COG1940	carbohydrate kinase activity
VSAL_RS07470	COG0653	protein targeting
VSAL_RS07495	COG0303	'Molybdopterin
VSAL_RS07500	COG0746	molybdenum cofactor guanylyltransferase activity
VSAL_RS07505	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VSAL_RS07510	COG4662	Binding-protein-dependent transport system inner membrane component
VSAL_RS07525	COG3852	Histidine kinase
VSAL_RS07530	COG0346	lactoylglutathione lyase activity
VSAL_RS07550	COG0586	Pfam SNARE associated Golgi protein
VSAL_RS07555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VSAL_RS07565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VSAL_RS07595	COG4372	Transposase
VSAL_RS07620	COG2897	thiosulfate sulfurtransferase activity
VSAL_RS07660	COG0826	peptidase U32
VSAL_RS07695	COG4336	lyase activity
VSAL_RS07700	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VSAL_RS07705	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VSAL_RS07710	COG1984	allophanate hydrolase subunit 2
VSAL_RS07730	COG4372	Transposase
VSAL_RS07735	COG1914	H( )-stimulated, divalent metal cation uptake system
VSAL_RS07760	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VSAL_RS07790	COG0243	molybdopterin cofactor binding
VSAL_RS07790	COG3383	formate dehydrogenase (NAD+) activity
VSAL_RS07795	COG0437	4 iron, 4 sulfur cluster binding
VSAL_RS07805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VSAL_RS07885	COG2026	Addiction module toxin, RelE StbE family
VSAL_RS07905	COG0456	acetyltransferase
VSAL_RS07945	COG1028	Short-chain dehydrogenase reductase Sdr
VSAL_RS07955	COG4221	oxidoreductase activity
VSAL_RS07960	COG2258	MOSC domain
VSAL_RS08000	COG0454	-acetyltransferase
VSAL_RS08000	COG0456	acetyltransferase
VSAL_RS08030	COG3394	polysaccharide catabolic process
VSAL_RS08040	COG0110	maltose O-acetyltransferase activity
VSAL_RS08050	COG0384	phenazine biosynthesis protein PhzF
VSAL_RS08055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VSAL_RS08060	COG2226	methyltransferase
VSAL_RS08085	COG1418	mRNA catabolic process
VSAL_RS08090	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VSAL_RS08100	COG0534	Mate efflux family protein
VSAL_RS08105	COG0500	methyltransferase
VSAL_RS08150	COG1309	transcriptional regulator
VSAL_RS08170	COG0402	S-adenosylhomocysteine deaminase activity
VSAL_RS08190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VSAL_RS08200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VSAL_RS08200	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VSAL_RS08205	COG3008	intermembrane lipid transfer
VSAL_RS08210	COG2995	paraquat-inducible protein a
VSAL_RS08215	COG1132	(ABC) transporter
VSAL_RS08220	COG1956	GAF domain-containing protein
VSAL_RS08225	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VSAL_RS08255	COG0167	dihydroorotate dehydrogenase activity
VSAL_RS08265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VSAL_RS08265	COG0116	Belongs to the methyltransferase superfamily
VSAL_RS08275	COG0488	(ABC) transporter
VSAL_RS08290	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VSAL_RS08295	COG1067	ATP-dependent peptidase activity
VSAL_RS08300	COG3120	sequence-specific DNA binding
VSAL_RS08310	COG2205	protein histidine kinase activity
VSAL_RS08310	COG0784	Response regulator, receiver
VSAL_RS08325	COG3278	Belongs to the heme-copper respiratory oxidase family
VSAL_RS08340	COG2010	Cytochrome c
VSAL_RS08350	COG2217	Heavy metal translocating P-type atpase
VSAL_RS08365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VSAL_RS08370	COG0589	response to stress
VSAL_RS08375	COG0037	tRNA processing
VSAL_RS08390	COG4372	Transposase
VSAL_RS08410	COG3842	ATPase activity
VSAL_RS08420	COG1177	transmembrane transport
VSAL_RS08430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VSAL_RS08435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VSAL_RS08440	COG0583	DNA-binding transcription factor activity
VSAL_RS08445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VSAL_RS08480	COG0494	nUDIX hydrolase
VSAL_RS08550	COG1609	Transcriptional regulator
VSAL_RS08555	COG1757	Na H antiporter
VSAL_RS08560	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VSAL_RS08565	COG2207	Transcriptional regulator
VSAL_RS08565	COG1917	Cupin 2, conserved barrel domain protein
VSAL_RS08570	COG0697	spore germination
VSAL_RS08580	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VSAL_RS08585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSAL_RS08585	COG1263	PTS System
VSAL_RS08600	COG1609	Transcriptional regulator
VSAL_RS08630	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VSAL_RS08685	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
VSAL_RS08690	COG0840	transmembrane signaling receptor activity
VSAL_RS08735	COG2944	sequence-specific DNA binding
VSAL_RS08740	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
VSAL_RS08780	COG4372	Transposase
VSAL_RS08790	COG1446	asparaginase
VSAL_RS08795	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VSAL_RS08800	COG1447	Phosphotransferase system cellobiose-specific component IIA
VSAL_RS08815	COG4372	Transposase
VSAL_RS08835	COG0071	Belongs to the small heat shock protein (HSP20) family
VSAL_RS08855	COG4372	Transposase
VSAL_RS08865	COG0484	heat shock protein binding
VSAL_RS08870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VSAL_RS08890	COG2925	Exonuclease
VSAL_RS08910	COG0154	amidase activity
VSAL_RS08915	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VSAL_RS08920	COG1448	Aminotransferase
VSAL_RS08930	COG0583	DNA-binding transcription factor activity
VSAL_RS08970	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VSAL_RS08980	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VSAL_RS08990	COG1643	Atp-dependent helicase
VSAL_RS09020	COG1254	Belongs to the acylphosphatase family
VSAL_RS09035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VSAL_RS09050	COG0584	glycerophosphoryl diester phosphodiesterase
VSAL_RS09055	COG2271	Major facilitator Superfamily
VSAL_RS09090	COG0582	viral genome integration into host DNA
VSAL_RS09110	COG3706	GGDEF domain
VSAL_RS09125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VSAL_RS09130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VSAL_RS09135	COG1666	GTP binding
VSAL_RS09150	COG0776	regulation of translation
VSAL_RS09155	COG0072	phenylalanine-tRNA ligase activity
VSAL_RS09155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VSAL_RS09160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VSAL_RS09210	COG4104	PAAR repeat-containing protein
VSAL_RS09215	COG3501	Rhs element vgr protein
VSAL_RS09230	COG4372	Transposase
VSAL_RS09235	COG3501	Rhs element vgr protein
VSAL_RS09240	COG0748	coenzyme F420 binding
VSAL_RS09245	COG3721	Heme iron utilization protein
VSAL_RS09260	COG0811	peptide transport
VSAL_RS09265	COG0848	biopolymer transport protein
VSAL_RS09275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VSAL_RS09280	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VSAL_RS09285	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VSAL_RS09290	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VSAL_RS09295	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VSAL_RS09300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VSAL_RS09305	COG4326	sporulation control protein
VSAL_RS09315	COG3097	Belongs to the UPF0267 family
VSAL_RS09320	COG0443	Heat shock 70 kDa protein
VSAL_RS09345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VSAL_RS09350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VSAL_RS09370	COG0814	amino acid
VSAL_RS09380	COG3385	transposase activity
VSAL_RS09400	COG4372	Transposase
VSAL_RS09410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VSAL_RS09435	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VSAL_RS09440	COG1454	alcohol dehydrogenase
VSAL_RS09450	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VSAL_RS09480	COG1115	amino acid carrier protein
VSAL_RS09485	COG0668	transmembrane transport
VSAL_RS09490	COG1280	lysine exporter protein (LysE YggA)
VSAL_RS09495	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VSAL_RS09500	COG1396	sequence-specific DNA binding
VSAL_RS09505	COG3550	peptidyl-serine autophosphorylation
VSAL_RS09520	COG3046	protein related to deoxyribodipyrimidine photolyase
VSAL_RS09525	COG0625	glutathione transferase activity
VSAL_RS09550	COG1823	symporter activity
VSAL_RS09555	COG0500	methyltransferase
VSAL_RS09560	COG1213	nucleotidyl transferase
VSAL_RS09570	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VSAL_RS09595	COG0840	transmembrane signaling receptor activity
VSAL_RS09605	COG3706	GGDEF domain
VSAL_RS09620	COG0443	Heat shock 70 kDa protein
VSAL_RS09660	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VSAL_RS09665	COG4988	ABC transporter
VSAL_RS09670	COG0492	ferredoxin-NADP+ reductase activity
VSAL_RS09675	COG0686	Belongs to the AlaDH PNT family
VSAL_RS09690	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VSAL_RS09695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VSAL_RS09700	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VSAL_RS09705	COG3118	belongs to the thioredoxin family
VSAL_RS09715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VSAL_RS09725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VSAL_RS09730	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VSAL_RS09740	COG3139	Protein of unknown function (DUF1315)
VSAL_RS09745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VSAL_RS09750	COG1454	alcohol dehydrogenase
VSAL_RS09750	COG1012	belongs to the aldehyde dehydrogenase family
VSAL_RS09770	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VSAL_RS09780	COG2056	Na+-H+ antiporter family
VSAL_RS09785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VSAL_RS09800	COG0346	lactoylglutathione lyase activity
VSAL_RS09805	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VSAL_RS09810	COG4660	Part of a membrane complex involved in electron transport
VSAL_RS09815	COG4659	FMN binding
VSAL_RS09820	COG4658	electron transport chain
VSAL_RS09825	COG4656	Part of a membrane complex involved in electron transport
VSAL_RS09830	COG2878	Part of a membrane complex involved in electron transport
VSAL_RS09835	COG4657	Part of a membrane complex involved in electron transport
VSAL_RS09845	COG0556	nucleotide-excision repair
VSAL_RS09850	COG2204	response regulator
VSAL_RS09855	COG2198	Histidine kinase
VSAL_RS09860	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VSAL_RS09865	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VSAL_RS09870	COG0315	cyclic pyranopterin monophosphate synthase activity
VSAL_RS09875	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VSAL_RS09880	COG0314	molybdopterin synthase activity
VSAL_RS09895	COG0189	ligase activity
VSAL_RS09895	COG4067	protein conserved in archaea
VSAL_RS09900	COG0500	methyltransferase
VSAL_RS09905	COG4106	trans-aconitate 2-methyltransferase activity
VSAL_RS09910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VSAL_RS09915	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VSAL_RS09920	COG0632	four-way junction helicase activity
VSAL_RS09925	COG2255	four-way junction helicase activity
VSAL_RS09930	COG1271	oxidase subunit
VSAL_RS09935	COG1294	oxidase, subunit
VSAL_RS09950	COG0824	Thioesterase
VSAL_RS09955	COG0811	peptide transport
VSAL_RS09970	COG0823	Involved in the tonB-independent uptake of proteins
VSAL_RS09975	COG2885	chlorophyll binding
VSAL_RS09980	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VSAL_RS09985	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VSAL_RS09995	COG0662	Cupin 2, conserved barrel domain protein
VSAL_RS09995	COG2207	Transcriptional regulator
VSAL_RS10000	COG1566	PFAM secretion protein HlyD family protein
VSAL_RS10010	COG0628	permease
VSAL_RS10040	COG0768	penicillin binding
VSAL_RS10055	COG0768	penicillin binding
VSAL_RS10065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VSAL_RS10070	COG2153	protein acetylation
VSAL_RS10125	COG1475	DNA binding
VSAL_RS10150	COG4372	Transposase
VSAL_RS10155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VSAL_RS10160	COG0303	'Molybdopterin
VSAL_RS10165	COG0302	gtp cyclohydrolase
VSAL_RS10175	COG0733	neurotransmitter:sodium symporter activity
VSAL_RS10180	COG3012	SEC-C Motif Domain Protein
VSAL_RS10185	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VSAL_RS10190	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VSAL_RS10195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VSAL_RS10200	COG0215	cysteine-tRNA ligase activity
VSAL_RS10205	COG1435	thymidine kinase activity
VSAL_RS10240	COG0601	transmembrane transport
VSAL_RS10245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VSAL_RS10250	COG0444	Belongs to the ABC transporter superfamily
VSAL_RS10260	COG0840	transmembrane signaling receptor activity
VSAL_RS10265	COG2850	peptidyl-arginine hydroxylation
VSAL_RS10270	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VSAL_RS10275	COG3385	transposase activity
VSAL_RS10280	COG1882	Formate acetyltransferase
VSAL_RS10285	COG2116	formate transmembrane transporter activity
VSAL_RS10310	COG2999	glutathione oxidoreductase activity
VSAL_RS10340	COG1566	PFAM secretion protein HlyD family protein
VSAL_RS10350	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VSAL_RS10360	COG1522	sequence-specific DNA binding
VSAL_RS10365	COG1946	Acyl-CoA thioesterase
VSAL_RS10370	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VSAL_RS10385	COG0803	Belongs to the bacterial solute-binding protein 9 family
VSAL_RS10390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VSAL_RS10405	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
VSAL_RS10435	COG3070	regulator of competence-specific genes
VSAL_RS10440	COG1609	Transcriptional regulator
VSAL_RS10445	COG3381	protein complex oligomerization
VSAL_RS10450	COG0745	RESPONSE REGULATOR receiver
VSAL_RS10475	COG4720	Psort location CytoplasmicMembrane, score
VSAL_RS10510	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
VSAL_RS10520	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VSAL_RS10530	COG0437	4 iron, 4 sulfur cluster binding
VSAL_RS10535	COG3301	Polysulphide reductase, NrfD
VSAL_RS10540	COG1138	Cytochrome C-type biogenesis protein
VSAL_RS10550	COG3088	subunit of a heme lyase
VSAL_RS10550	COG4235	cytochrome complex assembly
VSAL_RS10560	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VSAL_RS10565	COG0583	DNA-binding transcription factor activity
VSAL_RS10570	COG0671	phosphoesterase, PA-phosphatase related
VSAL_RS10575	COG2067	long-chain fatty acid transport protein
VSAL_RS10630	COG2814	Major facilitator Superfamily
VSAL_RS10645	COG0534	Mate efflux family protein
VSAL_RS10650	COG1136	(ABC) transporter
VSAL_RS10665	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VSAL_RS10670	COG3385	transposase activity
VSAL_RS10675	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VSAL_RS10680	COG0569	domain protein
VSAL_RS10680	COG2985	domain, Protein
VSAL_RS10685	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VSAL_RS10690	COG1737	Transcriptional regulator
VSAL_RS10695	COG0076	glutamate decarboxylase activity
VSAL_RS10715	COG3070	regulator of competence-specific genes
VSAL_RS10745	COG4372	Transposase
VSAL_RS10760	COG2067	long-chain fatty acid transport protein
VSAL_RS10770	COG1051	belongs to the nudix hydrolase family
VSAL_RS10800	COG0670	Belongs to the BI1 family
VSAL_RS10805	COG1126	abc transporter atp-binding protein
VSAL_RS10810	COG0765	amino acid transport
VSAL_RS10815	COG4597	amino acid ABC transporter
VSAL_RS10820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VSAL_RS10825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VSAL_RS10825	COG1648	precorrin-2 dehydrogenase activity
VSAL_RS10830	COG2188	Transcriptional regulator
VSAL_RS10845	COG0247	lactate metabolic process
VSAL_RS10845	COG0277	FAD linked oxidase domain protein
VSAL_RS10855	COG0517	IMP dehydrogenase activity
VSAL_RS10855	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VSAL_RS10855	COG0617	tRNA 3'-terminal CCA addition
VSAL_RS10860	COG3344	reverse transcriptase
VSAL_RS10865	COG2217	Heavy metal translocating P-type atpase
VSAL_RS10870	COG3437	response regulator, receiver
VSAL_RS10905	COG0840	transmembrane signaling receptor activity
VSAL_RS10910	COG2258	MOSC domain
VSAL_RS10920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VSAL_RS10935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VSAL_RS10940	COG1061	Type III restriction enzyme res subunit
VSAL_RS10950	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VSAL_RS10980	COG1028	Short-chain dehydrogenase reductase Sdr
VSAL_RS10990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VSAL_RS11010	COG0824	Thioesterase
VSAL_RS11025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VSAL_RS11040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VSAL_RS11045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VSAL_RS11075	COG3102	Protein conserved in bacteria
VSAL_RS11080	COG0018	arginyl-trna synthetase
VSAL_RS11085	COG3092	negative regulation of chromosome organization
VSAL_RS11090	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VSAL_RS11095	COG0280	phosphate acetyltransferase
VSAL_RS11095	COG0857	belongs to the CobB CobQ family
VSAL_RS11100	COG4372	Transposase
VSAL_RS11125	COG0573	inorganic phosphate transmembrane transporter activity
VSAL_RS11130	COG0581	inorganic phosphate transmembrane transporter activity
VSAL_RS11135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VSAL_RS11170	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VSAL_RS11185	COG1879	ABC-type sugar transport system periplasmic component
VSAL_RS11190	COG1803	Methylglyoxal synthase
VSAL_RS11195	COG0210	DNA helicase
VSAL_RS11200	COG1289	transmembrane transporter activity
VSAL_RS11245	COG0322	excinuclease ABC activity
VSAL_RS11250	COG2197	response regulator
VSAL_RS11255	COG0417	DNA replication proofreading
VSAL_RS11265	COG1757	Na H antiporter
VSAL_RS11275	COG3713	MltA-interacting MipA family protein
VSAL_RS11280	COG2186	Transcriptional regulator
VSAL_RS11285	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VSAL_RS11290	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VSAL_RS11305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VSAL_RS11310	COG3706	GGDEF domain
VSAL_RS11320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VSAL_RS11325	COG1902	pentaerythritol trinitrate reductase activity
VSAL_RS11325	COG0446	pyridine nucleotide-disulphide oxidoreductase
VSAL_RS11330	COG0616	signal peptide processing
VSAL_RS11335	COG0252	asparaginase activity
VSAL_RS11340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VSAL_RS11360	COG4372	Transposase
VSAL_RS11365	COG1025	Belongs to the peptidase M16 family
VSAL_RS11370	COG2062	phosphohistidine phosphatase, SixA
VSAL_RS11375	COG2840	Smr protein MutS2
VSAL_RS11380	COG2890	protein-(glutamine-N5) methyltransferase activity
VSAL_RS11385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VSAL_RS11390	COG2860	membrane
VSAL_RS11395	COG1285	pathogenesis
VSAL_RS11400	COG3101	peptidyl-lysine hydroxylation
VSAL_RS11410	COG3706	GGDEF domain
VSAL_RS11420	COG1560	Kdo2-lipid A biosynthetic process
VSAL_RS11425	COG0038	chloride channel
VSAL_RS11435	COG4372	Transposase
VSAL_RS11455	COG2226	methyltransferase
VSAL_RS11460	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VSAL_RS11465	COG3013	Belongs to the UPF0304 family
VSAL_RS11470	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VSAL_RS11480	COG4565	transcriptional regulatory protein
VSAL_RS11485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VSAL_RS11495	COG0513	Belongs to the DEAD box helicase family
VSAL_RS11525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VSAL_RS11530	COG2915	High frequency lysogenization protein hflD homolog
VSAL_RS11540	COG3604	Transcriptional regulator
VSAL_RS11545	COG1773	rubredoxin
VSAL_RS11545	COG0426	domain, Protein
VSAL_RS11550	COG0446	pyridine nucleotide-disulphide oxidoreductase
VSAL_RS11555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VSAL_RS11570	COG1187	pseudouridine synthase activity
VSAL_RS11580	COG2719	SpoVR family
VSAL_RS11585	COG2718	Belongs to the UPF0229 family
VSAL_RS11590	COG2766	serine protein kinase
VSAL_RS11595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VSAL_RS11605	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VSAL_RS11615	COG1278	Cold shock
VSAL_RS11620	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VSAL_RS11625	COG0542	response to heat
VSAL_RS11630	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VSAL_RS11640	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VSAL_RS11645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VSAL_RS11650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VSAL_RS11655	COG0539	negative regulation of cytoplasmic translation
VSAL_RS11660	COG0776	regulation of translation
VSAL_RS11665	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VSAL_RS11670	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VSAL_RS11675	COG0284	orotidine-5'-phosphate decarboxylase activity
VSAL_RS11680	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VSAL_RS11680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VSAL_RS11685	COG0489	protein tyrosine kinase activity
VSAL_RS11690	COG0572	uridine kinase
VSAL_RS11700	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VSAL_RS11710	COG0659	secondary active sulfate transmembrane transporter activity
VSAL_RS11715	COG1530	ribonuclease E activity
VSAL_RS11720	COG0564	pseudouridine synthase activity
VSAL_RS11725	COG0424	maF-like protein
VSAL_RS11730	COG1399	metal-binding, possibly nucleic acid-binding protein
VSAL_RS11735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VSAL_RS11740	COG0416	fatty acid biosynthetic process
VSAL_RS11745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VSAL_RS11770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VSAL_RS11775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VSAL_RS11780	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VSAL_RS11785	COG0470	DNA polymerase III
VSAL_RS11790	COG0084	hydrolase, TatD family'
VSAL_RS11805	COG4372	Transposase
VSAL_RS11815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSAL_RS11815	COG1263	PTS System
VSAL_RS11825	COG0733	neurotransmitter:sodium symporter activity
VSAL_RS11865	COG4372	Transposase
VSAL_RS11870	COG4372	Transposase
VSAL_RS11885	COG1024	Enoyl-CoA hydratase
VSAL_RS11885	COG1250	3-hydroxyacyl-CoA dehydrogenase
VSAL_RS11895	COG2067	long-chain fatty acid transport protein
VSAL_RS11910	COG2853	Lipoprotein
VSAL_RS11925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VSAL_RS11930	COG1138	Cytochrome C-type biogenesis protein
VSAL_RS11935	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VSAL_RS11940	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VSAL_RS11945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VSAL_RS11950	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VSAL_RS11955	COG4133	protoheme IX ABC transporter activity
VSAL_RS11965	COG0835	chemotaxis
VSAL_RS11975	COG1192	Involved in chromosome partitioning
VSAL_RS11980	COG2201	protein-glutamate methylesterase activity
VSAL_RS11985	COG2198	Histidine kinase
VSAL_RS11985	COG0784	Response regulator, receiver
VSAL_RS11985	COG0643	Histidine kinase
VSAL_RS11990	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VSAL_RS12030	COG1684	flagellar biosynthetic protein fliR
VSAL_RS12035	COG1987	bacterial-type flagellum assembly
VSAL_RS12085	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VSAL_RS12095	COG1677	Flagellar hook-basal body complex protein FliE
VSAL_RS12115	COG1516	flagellar protein fliS
VSAL_RS12125	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VSAL_RS12135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VSAL_RS12140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VSAL_RS12145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VSAL_RS12180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VSAL_RS12205	COG1705	Flagellar rod assembly protein muramidase FlgJ
VSAL_RS12205	COG3951	Flagellar rod assembly protein muramidase FlgJ
VSAL_RS12210	COG1706	bacterial-type flagellum-dependent cell motility
VSAL_RS12215	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VSAL_RS12220	COG4786	Flagellar basal body rod
VSAL_RS12225	COG4787	bacterial-type flagellum-dependent cell motility
VSAL_RS12245	COG1815	bacterial-type flagellum-dependent cell motility
VSAL_RS12255	COG0835	chemotaxis
VSAL_RS12255	COG0784	Response regulator, receiver
VSAL_RS12265	COG2747	anti-sigma28 factor FlgM
VSAL_RS12300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VSAL_RS12315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VSAL_RS12320	COG3115	cell septum assembly
VSAL_RS12335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSAL_RS12340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VSAL_RS12345	COG2190	(PTS) system
VSAL_RS12350	COG2837	iron assimilation
VSAL_RS12370	COG3005	denitrification pathway
VSAL_RS12390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VSAL_RS12395	COG3850	Histidine kinase
VSAL_RS12400	COG2197	response regulator
VSAL_RS12425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VSAL_RS12430	COG1876	peptidase activity
VSAL_RS12440	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VSAL_RS12445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VSAL_RS12450	COG2716	regulation of RNA biosynthetic process
VSAL_RS12455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VSAL_RS12470	COG4783	chaperone-mediated protein folding
VSAL_RS12475	COG1393	Belongs to the ArsC family
VSAL_RS12495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VSAL_RS12500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VSAL_RS12505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VSAL_RS12510	COG0121	glutamine amidotransferase
VSAL_RS12515	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VSAL_RS12525	COG1960	acyl-CoA dehydrogenase activity
VSAL_RS12545	COG0328	RNA-DNA hybrid ribonuclease activity
VSAL_RS12550	COG2226	methyltransferase
VSAL_RS12555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VSAL_RS12560	COG1388	LysM domain
VSAL_RS12560	COG0741	lytic transglycosylase activity
VSAL_RS12565	COG4372	Transposase
VSAL_RS12585	COG3021	interspecies interaction between organisms
VSAL_RS12605	COG0825	malonyl-CoA metabolic process
VSAL_RS12610	COG0587	DNA-directed DNA polymerase activity
VSAL_RS12615	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VSAL_RS12620	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VSAL_RS12625	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VSAL_RS12635	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VSAL_RS12640	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VSAL_RS12650	COG0750	zinc metalloprotease
VSAL_RS12655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VSAL_RS12660	COG0575	Belongs to the CDS family
VSAL_RS12665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VSAL_RS12670	COG0233	cytoplasmic translational termination
VSAL_RS12675	COG0528	UMP kinase activity
VSAL_RS12680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VSAL_RS12685	COG0052	Belongs to the universal ribosomal protein uS2 family
VSAL_RS12690	COG0024	Methionine aminopeptidase
VSAL_RS12710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VSAL_RS12715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VSAL_RS12720	COG1862	Preprotein translocase
VSAL_RS12725	COG0343	queuine tRNA-ribosyltransferase activity
VSAL_RS12730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VSAL_RS12735	COG0517	IMP dehydrogenase activity
VSAL_RS12745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VSAL_RS12750	COG0583	DNA-binding transcription factor activity
VSAL_RS12755	COG0450	alkyl hydroperoxide reductase
VSAL_RS12760	COG3142	Participates in the control of copper homeostasis
VSAL_RS12765	COG3111	PFAM Bacterial OB fold (BOF) protein
VSAL_RS12805	COG0704	Plays a role in the regulation of phosphate uptake
VSAL_RS12810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VSAL_RS12815	COG0581	inorganic phosphate transmembrane transporter activity
VSAL_RS12830	COG5002	protein histidine kinase activity
VSAL_RS12835	COG0745	RESPONSE REGULATOR receiver
VSAL_RS12860	COG4372	Transposase
VSAL_RS12875	COG0477	Major facilitator Superfamily
VSAL_RS12885	COG1609	Transcriptional regulator
VSAL_RS12890	COG0826	peptidase U32
VSAL_RS12895	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VSAL_RS12915	COG0484	heat shock protein binding
VSAL_RS12930	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VSAL_RS12935	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VSAL_RS12940	COG0497	DNA recombination
VSAL_RS12945	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSAL_RS12950	COG2914	Belongs to the UPF0125 (RnfH) family
VSAL_RS12955	COG2867	negative regulation of translational initiation
VSAL_RS12960	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VSAL_RS12965	COG0582	viral genome integration into host DNA
VSAL_RS12995	COG4372	Transposase
VSAL_RS13000	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VSAL_RS13005	COG4372	Transposase
VSAL_RS13020	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VSAL_RS13025	COG1982	Orn Lys Arg decarboxylase major
VSAL_RS13030	COG0531	amino acid
VSAL_RS13035	COG1115	amino acid carrier protein
VSAL_RS13040	COG3710	Transcriptional regulator
VSAL_RS13050	COG2391	methyltransferase activity
VSAL_RS13065	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VSAL_RS13070	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VSAL_RS13075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VSAL_RS13080	COG5413	integral membrane protein
VSAL_RS13085	COG4135	transport system, permease component
VSAL_RS13090	COG4136	ATPase activity
VSAL_RS13095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VSAL_RS13100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VSAL_RS13105	COG1388	LysM domain
VSAL_RS13105	COG4942	peptidase
VSAL_RS13110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VSAL_RS13115	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VSAL_RS13120	COG0585	pseudouridine synthase activity
VSAL_RS13125	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VSAL_RS13130	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VSAL_RS13135	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VSAL_RS13140	COG0148	phosphopyruvate hydratase activity
VSAL_RS13145	COG0504	CTP synthase activity
VSAL_RS13150	COG3956	TIGRFAM MazG family protein
VSAL_RS13160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VSAL_RS13165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VSAL_RS13175	COG0736	holo-[acyl-carrier-protein] synthase activity
VSAL_RS13180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VSAL_RS13185	COG1381	Involved in DNA repair and RecF pathway recombination
VSAL_RS13190	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VSAL_RS13195	COG0571	ribonuclease III activity
VSAL_RS13205	COG0481	GTPase activity
VSAL_RS13225	COG1595	DNA-templated transcription, initiation
VSAL_RS13230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VSAL_RS13235	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VSAL_RS13240	COG0354	folic acid binding
VSAL_RS13250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VSAL_RS13255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VSAL_RS13260	COG3079	Belongs to the UPF0149 family
VSAL_RS13265	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VSAL_RS13270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VSAL_RS13275	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VSAL_RS13285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VSAL_RS13295	COG0668	transmembrane transport
VSAL_RS13300	COG3022	response to hydroperoxide
VSAL_RS13305	COG1115	amino acid carrier protein
VSAL_RS13320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VSAL_RS13330	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VSAL_RS13335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VSAL_RS13340	COG0083	homoserine kinase activity
VSAL_RS13350	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VSAL_RS13355	COG0745	RESPONSE REGULATOR receiver
VSAL_RS13365	COG0784	Response regulator, receiver
VSAL_RS13365	COG2198	Histidine kinase
VSAL_RS13365	COG5002	protein histidine kinase activity
VSAL_RS13375	COG0069	glutamate synthase activity
VSAL_RS13375	COG0067	glutamate synthase
VSAL_RS13375	COG0070	glutamate synthase
VSAL_RS13410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VSAL_RS13420	COG2860	membrane
VSAL_RS13425	COG0739	heme binding
VSAL_RS13440	COG0316	Belongs to the HesB IscA family
VSAL_RS13445	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VSAL_RS13450	COG0628	permease
VSAL_RS13455	COG2813	Specifically methylates the guanine in position
VSAL_RS13460	COG2205	protein histidine kinase activity
VSAL_RS13460	COG0784	Response regulator, receiver
VSAL_RS13480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VSAL_RS13485	COG0444	Belongs to the ABC transporter superfamily
VSAL_RS13490	COG4608	Belongs to the ABC transporter superfamily
VSAL_RS13500	COG2971	BadF BadG BcrA BcrD
VSAL_RS13515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VSAL_RS13520	COG3842	ATPase activity
VSAL_RS13530	COG1840	ABC-type Fe3 transport system, periplasmic component
VSAL_RS13535	COG0004	ammonium transporteR
VSAL_RS13545	COG3112	Uncharacterised protein family (UPF0231)
VSAL_RS13550	COG3835	regulator
VSAL_RS13555	COG2610	gluconate transmembrane transporter activity
VSAL_RS13560	COG1929	Belongs to the glycerate kinase type-1 family
VSAL_RS13565	COG1049	propionate catabolic process, 2-methylcitrate cycle
VSAL_RS13575	COG1752	Esterase of the alpha-beta hydrolase superfamily
VSAL_RS13580	COG4372	Transposase
VSAL_RS13650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VSAL_RS13655	COG1643	Atp-dependent helicase
VSAL_RS13660	COG1489	DNA binding
VSAL_RS13680	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VSAL_RS13685	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VSAL_RS13690	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VSAL_RS13695	COG4372	Transposase
VSAL_RS13710	COG0842	Transport permease protein
VSAL_RS13715	COG1131	(ABC) transporter
VSAL_RS13720	COG0288	reversible hydration of carbon dioxide
VSAL_RS13755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VSAL_RS13760	COG0508	dehydrogenase complex catalyzes the overall conversion of
VSAL_RS13765	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VSAL_RS13770	COG2186	Transcriptional regulator
VSAL_RS13780	COG0157	Belongs to the NadC ModD family
VSAL_RS13790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSAL_RS13805	COG0237	dephospho-CoA kinase activity
VSAL_RS13810	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VSAL_RS13815	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VSAL_RS13820	COG0494	nUDIX hydrolase
VSAL_RS13825	COG0653	protein targeting
VSAL_RS13835	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VSAL_RS13840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VSAL_RS13845	COG0849	cell division
VSAL_RS13850	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VSAL_RS13855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VSAL_RS13860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VSAL_RS13865	COG0772	Belongs to the SEDS family
VSAL_RS13870	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VSAL_RS13875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VSAL_RS13880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VSAL_RS13890	COG0768	penicillin binding
VSAL_RS13895	COG3116	cell division
VSAL_RS13900	COG0275	rRNA processing
VSAL_RS13905	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VSAL_RS13910	COG3107	peptidoglycan biosynthetic process
VSAL_RS13915	COG0792	nuclease activity
VSAL_RS13920	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VSAL_RS13930	COG2969	positive regulation of protein catabolic process
VSAL_RS13935	COG0625	glutathione transferase activity
VSAL_RS13940	COG2857	Cytochrome c1
VSAL_RS13945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VSAL_RS13950	COG0723	plastoquinol--plastocyanin reductase activity
VSAL_RS13955	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VSAL_RS13960	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VSAL_RS13965	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VSAL_RS13970	COG3105	Protein conserved in bacteria
VSAL_RS13975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VSAL_RS13980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VSAL_RS13990	COG0187	DNA topoisomerase II activity
VSAL_RS13995	COG3150	esterase
VSAL_RS14005	COG3151	Protein conserved in bacteria
VSAL_RS14010	COG0494	nUDIX hydrolase
VSAL_RS14015	COG1538	Outer membrane efflux protein
VSAL_RS14020	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VSAL_RS14020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VSAL_RS14025	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VSAL_RS14035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VSAL_RS14040	COG3025	triphosphatase activity
VSAL_RS14045	COG1392	Phosphate transport regulator
VSAL_RS14050	COG0306	phosphate transporter
VSAL_RS14055	COG4991	sh3 domain protein
VSAL_RS14060	COG4372	Transposase
VSAL_RS14080	COG3409	Peptidoglycan-binding domain 1 protein
VSAL_RS14080	COG3267	Type II secretory pathway component ExeA
VSAL_RS14085	COG0617	tRNA 3'-terminal CCA addition
VSAL_RS14090	COG1968	undecaprenyl-diphosphatase activity
VSAL_RS14095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VSAL_RS14100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VSAL_RS14105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VSAL_RS14110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VSAL_RS14120	COG1610	YqeY-like protein
VSAL_RS14125	COG0358	DNA primase activity
VSAL_RS14150	COG0318	PFAM AMP-dependent synthetase and ligase
VSAL_RS14175	COG3706	GGDEF domain
VSAL_RS14185	COG0028	Belongs to the TPP enzyme family
VSAL_RS14190	COG4372	Transposase
VSAL_RS14205	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VSAL_RS14205	COG0165	Argininosuccinate lyase
VSAL_RS14215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VSAL_RS14220	COG0678	peroxiredoxin activity
VSAL_RS14220	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VSAL_RS14230	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VSAL_RS14265	COG4796	Type ii and iii secretion system protein
VSAL_RS14270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VSAL_RS14275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VSAL_RS14285	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VSAL_RS14290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VSAL_RS14295	COG0546	phosphoglycolate phosphatase activity
VSAL_RS14300	COG0180	Tryptophanyl-tRNA synthetase
VSAL_RS14305	COG0512	Glutamine amidotransferase of anthranilate synthase
VSAL_RS14320	COG4372	Transposase
VSAL_RS14325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VSAL_RS14335	COG1012	belongs to the aldehyde dehydrogenase family
VSAL_RS14345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VSAL_RS14350	COG1765	OsmC-like protein
VSAL_RS14355	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VSAL_RS14370	COG1609	Transcriptional regulator
VSAL_RS14375	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VSAL_RS14380	COG0254	rRNA binding
VSAL_RS14385	COG0281	malic enzyme
VSAL_RS14395	COG0626	cystathionine gamma-synthase activity
VSAL_RS14400	COG0460	homoserine dehydrogenase
VSAL_RS14400	COG0527	aspartate kinase activity
VSAL_RS14405	COG0583	DNA-binding transcription factor activity
VSAL_RS14410	COG1022	Amp-dependent synthetase and ligase
VSAL_RS14425	COG4372	Transposase
VSAL_RS14430	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VSAL_RS14435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VSAL_RS14440	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VSAL_RS14450	COG0137	argininosuccinate synthase activity
VSAL_RS14455	COG4372	Transposase
VSAL_RS14470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VSAL_RS14475	COG0359	binds to the 23S rRNA
VSAL_RS14485	COG2965	DNA replication, synthesis of RNA primer
VSAL_RS14490	COG0360	Binds together with S18 to 16S ribosomal RNA
VSAL_RS14495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VSAL_RS14500	COG0557	exoribonuclease II activity
VSAL_RS14505	COG1959	2 iron, 2 sulfur cluster binding
VSAL_RS14510	COG1017	nitric oxide dioxygenase activity
VSAL_RS14510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VSAL_RS14515	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VSAL_RS14520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VSAL_RS14530	COG0330	HflC and HflK could
VSAL_RS14535	COG0330	HflC and HflK could
VSAL_RS14540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VSAL_RS14545	COG1923	regulation of RNA biosynthetic process
VSAL_RS14550	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VSAL_RS14555	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VSAL_RS14565	COG0802	atpase or kinase
VSAL_RS14570	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VSAL_RS14625	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VSAL_RS14630	COG1162	GTPase activity
VSAL_RS14635	COG0688	phosphatidylethanolamine metabolic process
VSAL_RS14645	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VSAL_RS14650	COG1053	succinate dehydrogenase
VSAL_RS14655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VSAL_RS14660	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VSAL_RS14665	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VSAL_RS14670	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VSAL_RS14675	COG1509	lysine 2,3-aminomutase activity
VSAL_RS14680	COG0205	6-phosphofructokinase activity
VSAL_RS14695	COG0745	RESPONSE REGULATOR receiver
VSAL_RS14700	COG2205	protein histidine kinase activity
VSAL_RS14705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VSAL_RS14710	COG1045	serine acetyltransferase
VSAL_RS14715	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VSAL_RS14720	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VSAL_RS14725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VSAL_RS14730	COG4942	peptidase
VSAL_RS14740	COG1027	Aspartate ammonia-lyase
VSAL_RS14765	COG4232	protein-disulfide reductase activity
VSAL_RS14770	COG0363	glucosamine-6-phosphate deaminase activity
VSAL_RS14775	COG2213	PTS system mannitol-specific
VSAL_RS14775	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSAL_RS14780	COG0246	Mannitol dehydrogenase
VSAL_RS14785	COG3722	fumarate hydratase activity
VSAL_RS14800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VSAL_RS14805	COG0640	Transcriptional regulator
VSAL_RS14810	COG2199	diguanylate cyclase activity
VSAL_RS14815	COG1252	NADH dehydrogenase
VSAL_RS14820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VSAL_RS14825	COG1349	DNA-binding transcription factor activity
VSAL_RS14835	COG2095	MarC family integral membrane protein
VSAL_RS14840	COG3385	transposase activity
VSAL_RS14850	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VSAL_RS14855	COG0784	Response regulator, receiver
VSAL_RS14855	COG2205	protein histidine kinase activity
VSAL_RS14855	COG2198	Histidine kinase
VSAL_RS14860	COG2814	Major facilitator Superfamily
VSAL_RS14875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VSAL_RS14880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VSAL_RS14885	COG0511	ligase activity, forming carbon-carbon bonds
VSAL_RS14890	COG0439	Biotin carboxylase
VSAL_RS14895	COG2264	protein methyltransferase activity
VSAL_RS14900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VSAL_RS14915	COG0789	Transcriptional regulator
VSAL_RS14920	COG0138	bifunctional purine biosynthesis protein purh
VSAL_RS14925	COG0151	Belongs to the GarS family
VSAL_RS14930	COG3385	transposase activity
VSAL_RS14945	COG1253	flavin adenine dinucleotide binding
VSAL_RS14950	COG3068	Protein conserved in bacteria
VSAL_RS14955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VSAL_RS14965	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VSAL_RS14970	COG2816	NAD+ diphosphatase activity
VSAL_RS15005	COG2197	response regulator
VSAL_RS15040	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VSAL_RS15045	COG0085	RNA polymerase activity
VSAL_RS15050	COG0222	ribosome binding
VSAL_RS15055	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VSAL_RS15060	COG0081	regulation of translation
VSAL_RS15065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VSAL_RS15070	COG0250	Participates in transcription elongation, termination and antitermination
VSAL_RS15075	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VSAL_RS15105	COG1072	(Pantothenic acid kinase))
VSAL_RS15115	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VSAL_RS15125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VSAL_RS15140	COG4372	Transposase
VSAL_RS15170	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VSAL_RS15185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VSAL_RS15195	COG1309	transcriptional regulator
VSAL_RS15200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VSAL_RS15205	COG0534	Mate efflux family protein
VSAL_RS15215	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VSAL_RS15220	COG2937	Belongs to the GPAT DAPAT family
VSAL_RS15225	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VSAL_RS15230	COG3161	chorismate lyase activity
VSAL_RS15240	COG0705	Rhomboid family
VSAL_RS15245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VSAL_RS15255	COG2177	Part of the ABC transporter FtsEX involved in
VSAL_RS15260	COG2884	Cell division ATP-binding protein ftsE
VSAL_RS15265	COG0552	protein localization to endoplasmic reticulum
VSAL_RS15270	COG0742	ribosomal rna small subunit methyltransferase
VSAL_RS15300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VSAL_RS15305	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VSAL_RS15305	COG0316	Belongs to the HesB IscA family
VSAL_RS15310	COG1218	3'(2'),5'-bisphosphate nucleotidase
VSAL_RS15315	COG0494	nUDIX hydrolase
VSAL_RS15325	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VSAL_RS15330	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VSAL_RS15335	COG3156	type II secretion system protein K
VSAL_RS15340	COG4795	General secretion pathway protein
VSAL_RS15345	COG2165	general secretion pathway protein
VSAL_RS15350	COG2165	general secretion pathway protein
VSAL_RS15355	COG2165	general secretion pathway protein
VSAL_RS15360	COG1459	type II secretion system
VSAL_RS15365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSAL_RS15375	COG3031	protein transport across the cell outer membrane
VSAL_RS15380	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VSAL_RS15385	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VSAL_RS15390	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VSAL_RS15400	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VSAL_RS15405	COG2267	carboxylic ester hydrolase activity
VSAL_RS15410	COG0561	phosphatase activity
VSAL_RS15430	COG0456	acetyltransferase
VSAL_RS15435	COG1490	D-aminoacyl-tRNA deacylase activity
VSAL_RS15440	COG1295	ribonuclease BN
VSAL_RS15445	COG1217	gtp-binding protein TYPA
VSAL_RS15450	COG0174	glutamine synthetase
VSAL_RS15465	COG4372	Transposase
VSAL_RS15470	COG1522	sequence-specific DNA binding
VSAL_RS15475	COG0742	ribosomal rna small subunit methyltransferase
VSAL_RS15480	COG0589	response to stress
VSAL_RS15485	COG1528	Iron-storage protein
VSAL_RS15495	COG2081	HI0933 family
VSAL_RS15500	COG2200	EAL domain
VSAL_RS15500	COG2199	diguanylate cyclase activity
VSAL_RS15500	COG3287	FIST C domain
VSAL_RS15515	COG4372	Transposase
VSAL_RS15520	COG2200	EAL domain
VSAL_RS15520	COG2199	diguanylate cyclase activity
VSAL_RS15520	COG3287	FIST C domain
VSAL_RS15525	COG3148	PFAM DTW domain containing protein
VSAL_RS15535	COG0800	Aldolase
VSAL_RS15560	COG0071	Belongs to the small heat shock protein (HSP20) family
VSAL_RS15565	COG3385	transposase activity
VSAL_RS15570	COG3977	Valine--pyruvate aminotransferase
VSAL_RS15575	COG0752	glycyl-tRNA synthetase alpha subunit
VSAL_RS15580	COG0751	glycine-tRNA ligase activity
VSAL_RS15585	COG0366	Alpha amylase catalytic
VSAL_RS15595	COG0425	Belongs to the sulfur carrier protein TusA family
VSAL_RS15610	COG0583	DNA-binding transcription factor activity
VSAL_RS15615	COG0604	alcohol dehydrogenase
VSAL_RS15625	COG0183	Belongs to the thiolase family
VSAL_RS15630	COG1250	3-hydroxyacyl-CoA dehydrogenase
VSAL_RS15630	COG1024	Enoyl-CoA hydratase
VSAL_RS15635	COG1739	Uncharacterized protein family UPF0029
VSAL_RS15640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VSAL_RS15645	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
VSAL_RS15660	COG0612	Peptidase, M16
VSAL_RS15670	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VSAL_RS15680	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VSAL_RS15685	COG0352	thiamine-phosphate diphosphorylase activity
VSAL_RS15690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VSAL_RS15695	COG2104	thiamine diphosphate biosynthetic process
VSAL_RS15700	COG2022	thiamine diphosphate biosynthetic process
VSAL_RS15705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VSAL_RS15715	COG0006	proline dipeptidase activity
VSAL_RS15715	COG0006	proline dipeptidase activity
VSAL_RS15740	COG1322	Protein conserved in bacteria
VSAL_RS15745	COG2226	methyltransferase
VSAL_RS15755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VSAL_RS15760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VSAL_RS15765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VSAL_RS15770	COG0805	protein transport
VSAL_RS15785	COG0084	hydrolase, TatD family'
VSAL_RS15815	COG5433	transposase activity
VSAL_RS15825	COG2089	acid synthase
VSAL_RS15840	COG2244	polysaccharide biosynthetic process
VSAL_RS15890	COG1216	Glycosyl transferase, family 2
VSAL_RS15905	COG0463	Glycosyl transferase, family 2
VSAL_RS15920	COG4641	Protein conserved in bacteria
VSAL_RS15920	COG0438	transferase activity, transferring glycosyl groups
VSAL_RS15930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VSAL_RS16005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VSAL_RS16015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VSAL_RS16020	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VSAL_RS16050	COG0534	Mate efflux family protein
VSAL_RS16060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VSAL_RS16065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VSAL_RS16070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VSAL_RS16075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VSAL_RS16080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VSAL_RS16085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VSAL_RS16090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VSAL_RS16100	COG0356	it plays a direct role in the translocation of protons across the membrane
VSAL_RS16105	COG3312	ion transport
VSAL_RS16110	COG1475	DNA binding
VSAL_RS16115	COG1192	Involved in chromosome partitioning
VSAL_RS16120	COG0357	Ribosomal RNA small subunit methyltransferase G
VSAL_RS16125	COG0445	tRNA wobble uridine modification
VSAL_RS16175	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VSAL_RS16780	COG2815	serine threonine protein kinase
VSAL_RS16780	COG0515	serine threonine protein kinase
VSAL_RS16795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VSAL_RS16945	COG0513	Belongs to the DEAD box helicase family
VSAL_RS17170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VSAL_RS17865	COG1178	ABC-type Fe3 transport system permease component
VSAL_RS18200	COG0737	Belongs to the 5'-nucleotidase family
VSAL_RS18230	COG0529	Catalyzes the synthesis of activated sulfate
VSAL_RS18420	COG0297	glycogen (starch) synthase activity
VSAL_RS18420	COG0438	transferase activity, transferring glycosyl groups
VSAL_RS18955	COG0191	fructose-bisphosphate aldolase activity
VSAL_RS19115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VSAL_RS19120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VSAL_RS19125	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VSAL_RS19130	COG2027	D-alanyl-D-alanine carboxypeptidase
VSAL_RS19420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VSAL_RS19445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VSAL_RS19660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VSAL_RS19720	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VSAL_RS19870	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSAL_RS20135	COG0012	GTP binding
VSAL_RS20280	COG0326	Molecular chaperone. Has ATPase activity
VSAL_RS20295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VSAL_RS20420	COG0735	belongs to the Fur family
VSAL_RS20465	COG0372	Belongs to the citrate synthase family
VSAL_RS20995	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VSAL_RS21005	COG1805	sodium ion transport
VSAL_RS21180	COG0768	penicillin binding
VSAL_RS21200	COG0495	leucyl-tRNA aminoacylation
VSAL_RS21465	COG3083	sulfuric ester hydrolase activity
VSAL_RS22120	COG0706	membrane insertase activity
VSAL_RS22170	COG0187	DNA topoisomerase II activity
VSAL_RS22280	COG3501	Rhs element vgr protein
VSAL_RS22280	COG3409	Peptidoglycan-binding domain 1 protein
VSAL_RS22300	COG5301	cellulose 1,4-beta-cellobiosidase activity
VSAL_RS22305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSAL_RS22305	COG1263	PTS System
VSAL_RS22310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSAL_RS22310	COG1263	PTS System
VSAL_RS22315	COG4934	collagen metabolic process
VSAL_RS22335	COG3706	GGDEF domain
VSAL_RS22505	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane