locus-tag	class	description
HYG86_RS00010	COG0039	L-malate dehydrogenase activity
HYG86_RS00015	COG3180	Ammonia monooxygenase
HYG86_RS00020	COG0405	Gamma-glutamyltransferase
HYG86_RS00030	COG1012	belongs to the aldehyde dehydrogenase family
HYG86_RS00035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYG86_RS00065	COG3328	transposase activity
HYG86_RS00090	COG3212	peptidase
HYG86_RS00095	COG1595	DNA-templated transcription, initiation
HYG86_RS00110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYG86_RS00130	COG0653	protein targeting
HYG86_RS00145	COG0242	peptide deformylase activity
HYG86_RS00170	COG1484	DNA-dependent DNA replication
HYG86_RS00210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYG86_RS00245	COG0464	growth
HYG86_RS00250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HYG86_RS00280	COG5632	N-Acetylmuramoyl-L-alanine amidase
HYG86_RS00280	COG3409	Peptidoglycan-binding domain 1 protein
HYG86_RS00355	COG0740	serine-type endopeptidase activity
HYG86_RS00365	COG4626	Terminase
HYG86_RS00365	COG1802	Transcriptional regulator
HYG86_RS00455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG86_RS00455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG86_RS00475	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYG86_RS00485	COG3561	AntA/AntB antirepressor
HYG86_RS00530	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HYG86_RS00545	COG4974	Belongs to the 'phage' integrase family
HYG86_RS00555	COG4974	Belongs to the 'phage' integrase family
HYG86_RS00580	COG4974	Belongs to the 'phage' integrase family
HYG86_RS00590	COG4974	Belongs to the 'phage' integrase family
HYG86_RS00610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYG86_RS00615	COG0728	peptidoglycan biosynthetic process
HYG86_RS00620	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HYG86_RS00635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HYG86_RS00660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HYG86_RS00665	COG2165	general secretion pathway protein
HYG86_RS00675	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYG86_RS00720	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYG86_RS00745	COG4974	Belongs to the 'phage' integrase family
HYG86_RS00755	COG4974	Belongs to the 'phage' integrase family
HYG86_RS00765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYG86_RS00770	COG0728	peptidoglycan biosynthetic process
HYG86_RS00780	COG2089	acid synthase
HYG86_RS00790	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HYG86_RS00795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HYG86_RS00800	COG3562	capsule polysaccharide
HYG86_RS00810	COG1086	Polysaccharide biosynthesis protein
HYG86_RS00815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYG86_RS00840	COG0297	glycogen (starch) synthase activity
HYG86_RS00855	COG0482	sulfurtransferase activity
HYG86_RS00865	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HYG86_RS00870	COG3457	Alanine racemase
HYG86_RS00875	COG0626	cystathionine gamma-synthase activity
HYG86_RS00880	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HYG86_RS00905	COG2188	Transcriptional regulator
HYG86_RS00910	COG3546	catalase activity
HYG86_RS00920	COG1136	(ABC) transporter
HYG86_RS00920	COG0577	efflux transmembrane transporter activity
HYG86_RS00925	COG1136	(ABC) transporter
HYG86_RS00930	COG0577	efflux transmembrane transporter activity
HYG86_RS00930	COG1136	(ABC) transporter
HYG86_RS00960	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HYG86_RS00970	COG0156	8-amino-7-oxononanoate synthase activity
HYG86_RS00980	COG1063	alcohol dehydrogenase
HYG86_RS00995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYG86_RS01000	COG2171	N-acyltransferase activity
HYG86_RS01010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYG86_RS01015	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HYG86_RS01020	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HYG86_RS01030	COG2239	Acts as a magnesium transporter
HYG86_RS01035	COG0305	Participates in initiation and elongation during chromosome replication
HYG86_RS01040	COG1484	DNA-dependent DNA replication
HYG86_RS01050	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG86_RS01055	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HYG86_RS01080	COG3852	Histidine kinase
HYG86_RS01125	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HYG86_RS01130	COG0105	UTP biosynthetic process
HYG86_RS01155	COG0328	RNA-DNA hybrid ribonuclease activity
HYG86_RS01175	COG0577	efflux transmembrane transporter activity
HYG86_RS01175	COG1136	(ABC) transporter
HYG86_RS01220	COG3279	Response regulator of the LytR AlgR family
HYG86_RS01225	COG3290	protein histidine kinase activity
HYG86_RS01230	COG1472	Belongs to the glycosyl hydrolase 3 family
HYG86_RS01240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYG86_RS01250	COG1704	LemA family
HYG86_RS01275	COG0577	efflux transmembrane transporter activity
HYG86_RS01275	COG1136	(ABC) transporter
HYG86_RS01280	COG0784	Response regulator, receiver
HYG86_RS01280	COG2205	protein histidine kinase activity
HYG86_RS01285	COG0745	RESPONSE REGULATOR receiver
HYG86_RS01290	COG3480	Lon protease (S16) C-terminal proteolytic domain
HYG86_RS01310	COG0704	Plays a role in the regulation of phosphate uptake
HYG86_RS01320	COG0581	inorganic phosphate transmembrane transporter activity
HYG86_RS01325	COG0573	inorganic phosphate transmembrane transporter activity
HYG86_RS01330	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HYG86_RS01345	COG0613	PHP domain protein
HYG86_RS01350	COG3480	Lon protease (S16) C-terminal proteolytic domain
HYG86_RS01390	COG3344	reverse transcriptase
HYG86_RS01430	COG1131	(ABC) transporter
HYG86_RS01440	COG1595	DNA-templated transcription, initiation
HYG86_RS01450	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HYG86_RS01455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HYG86_RS01460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HYG86_RS01465	COG1160	GTP binding
HYG86_RS01505	COG1304	FMN binding
HYG86_RS01510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HYG86_RS01510	COG0539	negative regulation of cytoplasmic translation
HYG86_RS01520	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HYG86_RS01535	COG2813	Specifically methylates the guanine in position
HYG86_RS01545	COG1120	ATPase activity
HYG86_RS01550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG86_RS01560	COG0751	glycine-tRNA ligase activity
HYG86_RS01575	COG1381	Involved in DNA repair and RecF pathway recombination
HYG86_RS01580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HYG86_RS01590	COG3879	Bacterial protein of unknown function (DUF881)
HYG86_RS01595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HYG86_RS01600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HYG86_RS01605	COG1480	7TM receptor with intracellular HD hydrolase
HYG86_RS01610	COG1702	phosphate starvation-inducible protein PhoH
HYG86_RS01630	COG4864	UPF0365 protein
HYG86_RS01635	COG1030	water channel activity
HYG86_RS01640	COG1610	YqeY-like protein
HYG86_RS01660	COG0537	adenosine 5'-monophosphoramidase activity
HYG86_RS01670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYG86_RS01675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HYG86_RS01680	COG2264	protein methyltransferase activity
HYG86_RS01685	COG0484	heat shock protein binding
HYG86_RS01690	COG0443	Heat shock 70 kDa protein
HYG86_RS01700	COG1420	regulation of RNA biosynthetic process
HYG86_RS01705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYG86_RS01710	COG0481	GTPase activity
HYG86_RS01735	COG0268	Binds directly to 16S ribosomal RNA
HYG86_RS01745	COG2333	competence protein COMEC
HYG86_RS01745	COG0658	competence protein
HYG86_RS01755	COG3409	Peptidoglycan-binding domain 1 protein
HYG86_RS01755	COG3773	Cell wall hydrolase
HYG86_RS01760	COG0243	molybdopterin cofactor binding
HYG86_RS01765	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYG86_RS01770	COG1555	photosystem II stabilization
HYG86_RS01770	COG1596	polysaccharide export
HYG86_RS01785	COG2226	methyltransferase
HYG86_RS01790	COG0799	negative regulation of ribosome biogenesis
HYG86_RS01805	COG1534	Rna-binding protein
HYG86_RS01810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYG86_RS01820	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HYG86_RS01830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HYG86_RS01850	COG1994	Peptidase M50
HYG86_RS01865	COG0772	Belongs to the SEDS family
HYG86_RS01870	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HYG86_RS01875	COG2894	cell division
HYG86_RS01880	COG0850	regulation of cytokinetic process
HYG86_RS01885	COG0768	penicillin binding
HYG86_RS01895	COG1792	Involved in formation and maintenance of cell shape
HYG86_RS01900	COG1077	Cell shape determining protein MreB Mrl
HYG86_RS01905	COG2003	Belongs to the UPF0758 family
HYG86_RS01910	COG0424	maF-like protein
HYG86_RS01935	COG0521	Mo-molybdopterin cofactor biosynthetic process
HYG86_RS01940	COG2111	Na H antiporter
HYG86_RS01940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HYG86_RS01945	COG0651	ATP synthesis coupled electron transport
HYG86_RS01950	COG0651	ATP synthesis coupled electron transport
HYG86_RS01960	COG2111	Na H antiporter
HYG86_RS01975	COG1320	monovalent cation:proton antiporter activity
HYG86_RS01980	COG2212	antiporter activity
HYG86_RS01985	COG1863	multisubunit Na H antiporter MnhE subunit
HYG86_RS01990	COG2878	Part of a membrane complex involved in electron transport
HYG86_RS01990	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYG86_RS01995	COG4657	Part of a membrane complex involved in electron transport
HYG86_RS02000	COG4660	Part of a membrane complex involved in electron transport
HYG86_RS02005	COG3976	FMN-binding domain protein
HYG86_RS02005	COG1053	succinate dehydrogenase
HYG86_RS02005	COG0431	NADPH-dependent FMN reductase
HYG86_RS02010	COG4658	electron transport chain
HYG86_RS02015	COG4656	Part of a membrane complex involved in electron transport
HYG86_RS02020	COG1027	Aspartate ammonia-lyase
HYG86_RS02025	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HYG86_RS02045	COG5002	protein histidine kinase activity
HYG86_RS02055	COG0587	DNA-directed DNA polymerase activity
HYG86_RS02100	COG1122	ATPase activity
HYG86_RS02115	COG2323	membrane
HYG86_RS02140	COG0457	Tetratricopeptide repeat
HYG86_RS02145	COG0285	dihydrofolate synthase activity
HYG86_RS02150	COG0525	valine-tRNA ligase activity
HYG86_RS02180	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HYG86_RS02190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYG86_RS02195	COG1116	anion transmembrane transporter activity
HYG86_RS02200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYG86_RS02240	COG0456	acetyltransferase
HYG86_RS02245	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HYG86_RS02250	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HYG86_RS02255	COG0470	DNA polymerase III
HYG86_RS02255	COG1067	ATP-dependent peptidase activity
HYG86_RS02260	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HYG86_RS02265	COG0740	serine-type endopeptidase activity
HYG86_RS02270	COG0544	peptidyl-prolyl cis-trans isomerase activity
HYG86_RS02330	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HYG86_RS02370	COG4865	methylaspartate mutase activity
HYG86_RS02380	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG86_RS02390	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HYG86_RS02395	COG0534	Mate efflux family protein
HYG86_RS02400	COG1846	Transcriptional regulator
HYG86_RS02405	COG5002	protein histidine kinase activity
HYG86_RS02415	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HYG86_RS02420	COG5002	protein histidine kinase activity
HYG86_RS02425	COG0745	RESPONSE REGULATOR receiver
HYG86_RS02430	COG2201	protein-glutamate methylesterase activity
HYG86_RS02440	COG0840	transmembrane signaling receptor activity
HYG86_RS02480	COG0312	modulator of DNA gyrase
HYG86_RS02485	COG0312	modulator of DNA gyrase
HYG86_RS02510	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYG86_RS02520	COG0301	tRNA thio-modification
HYG86_RS02545	COG1533	DNA photolyase activity
HYG86_RS02560	COG5002	protein histidine kinase activity
HYG86_RS02565	COG0745	RESPONSE REGULATOR receiver
HYG86_RS02575	COG2431	L-lysine efflux transmembrane transporter activity
HYG86_RS02595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HYG86_RS02605	COG2223	nitrite transmembrane transporter activity
HYG86_RS02610	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HYG86_RS02615	COG1518	maintenance of DNA repeat elements
HYG86_RS02665	COG0840	transmembrane signaling receptor activity
HYG86_RS02665	COG3290	protein histidine kinase activity
HYG86_RS02670	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYG86_RS02680	COG1773	rubredoxin
HYG86_RS02680	COG0426	domain, Protein
HYG86_RS02690	COG0824	Thioesterase
HYG86_RS02705	COG0840	transmembrane signaling receptor activity
HYG86_RS02710	COG0840	transmembrane signaling receptor activity
HYG86_RS02720	COG3033	Beta-eliminating lyase
HYG86_RS02730	COG1408	metallophosphoesterase
HYG86_RS02750	COG0297	glycogen (starch) synthase activity
HYG86_RS02755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HYG86_RS02760	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HYG86_RS02765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYG86_RS02770	COG0626	cystathionine gamma-synthase activity
HYG86_RS02775	COG1854	S-ribosylhomocysteine lyase activity
HYG86_RS02780	COG2226	methyltransferase
HYG86_RS02800	COG2199	diguanylate cyclase activity
HYG86_RS02800	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYG86_RS02810	COG1032	radical SAM domain protein
HYG86_RS02830	COG0493	'glutamate synthase
HYG86_RS02845	COG0697	spore germination
HYG86_RS02865	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYG86_RS02885	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HYG86_RS02890	COG0534	Mate efflux family protein
HYG86_RS02895	COG3679	Belongs to the UPF0342 family
HYG86_RS02900	COG0667	Aldo Keto reductase
HYG86_RS02905	COG1757	Na H antiporter
HYG86_RS02915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYG86_RS02920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HYG86_RS02925	COG1328	CTP reductase activity
HYG86_RS02940	COG1132	(ABC) transporter
HYG86_RS02945	COG1132	(ABC) transporter
HYG86_RS02950	COG1592	Rubrerythrin
HYG86_RS02955	COG0285	dihydrofolate synthase activity
HYG86_RS02960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYG86_RS02965	COG1773	rubredoxin
HYG86_RS02980	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HYG86_RS03000	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HYG86_RS03005	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HYG86_RS03010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HYG86_RS03025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYG86_RS03035	COG3842	ATPase activity
HYG86_RS03040	COG1178	ABC-type Fe3 transport system permease component
HYG86_RS03050	COG0668	transmembrane transport
HYG86_RS03055	COG1473	amidohydrolase
HYG86_RS03080	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HYG86_RS03085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HYG86_RS03095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYG86_RS03105	COG2267	carboxylic ester hydrolase activity
HYG86_RS03120	COG0456	acetyltransferase
HYG86_RS03150	COG0277	FAD linked oxidase domain protein
HYG86_RS03155	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYG86_RS03160	COG2086	electron transfer activity
HYG86_RS03165	COG3875	lactate racemase activity
HYG86_RS03170	COG2186	Transcriptional regulator
HYG86_RS03175	COG1620	l-lactate permease
HYG86_RS03180	COG0745	RESPONSE REGULATOR receiver
HYG86_RS03185	COG3850	Histidine kinase
HYG86_RS03185	COG5002	protein histidine kinase activity
HYG86_RS03190	COG1228	amidohydrolase
HYG86_RS03195	COG1228	amidohydrolase
HYG86_RS03220	COG4537	Required for transformation and DNA binding
HYG86_RS03225	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HYG86_RS03245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG86_RS03250	COG2274	protein secretion by the type I secretion system
HYG86_RS03275	COG1132	(ABC) transporter
HYG86_RS03285	COG1132	(ABC) transporter
HYG86_RS03295	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HYG86_RS03300	COG1120	ATPase activity
HYG86_RS03305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG86_RS03315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYG86_RS03325	COG1492	cobalamin metabolic process
HYG86_RS03335	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HYG86_RS03340	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HYG86_RS03355	COG1797	cobyrinic acid a,c-diamide synthase activity
HYG86_RS03360	COG1164	Oligoendopeptidase f
HYG86_RS03370	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HYG86_RS03375	COG0351	phosphomethylpyrimidine kinase
HYG86_RS03385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG86_RS03390	COG0427	acetyl-CoA hydrolase
HYG86_RS03405	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG86_RS03435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG86_RS03440	COG2030	dehydratase
HYG86_RS03450	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYG86_RS03455	COG2086	electron transfer activity
HYG86_RS03460	COG1960	acyl-CoA dehydrogenase activity
HYG86_RS03465	COG0183	Belongs to the thiolase family
HYG86_RS03470	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYG86_RS03475	COG1024	Enoyl-CoA hydratase
HYG86_RS03490	COG1695	Transcriptional regulator
HYG86_RS03500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG86_RS03515	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HYG86_RS03520	COG4770	biotin carboxylase activity
HYG86_RS03530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYG86_RS03535	COG0346	lactoylglutathione lyase activity
HYG86_RS03540	COG1703	isobutyryl-CoA mutase activity
HYG86_RS03545	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG86_RS03545	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG86_RS03550	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG86_RS03550	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG86_RS03560	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYG86_RS03565	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYG86_RS03565	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYG86_RS03585	COG0494	nUDIX hydrolase
HYG86_RS03595	COG0733	neurotransmitter:sodium symporter activity
HYG86_RS03600	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HYG86_RS03605	COG2364	Membrane
HYG86_RS03610	COG3459	Glycosyltransferase 36 associated
HYG86_RS03615	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYG86_RS03640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYG86_RS03645	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HYG86_RS03710	COG1063	alcohol dehydrogenase
HYG86_RS03725	COG0702	epimerase
HYG86_RS03730	COG1846	Transcriptional regulator
HYG86_RS03750	COG1131	(ABC) transporter
HYG86_RS03755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYG86_RS03780	COG2502	aspartate--ammonia ligase
HYG86_RS03785	COG1773	rubredoxin
HYG86_RS03785	COG1592	Rubrerythrin
HYG86_RS03810	COG2197	response regulator
HYG86_RS03815	COG4585	Histidine kinase
HYG86_RS03820	COG1053	succinate dehydrogenase
HYG86_RS03825	COG1876	peptidase activity
HYG86_RS03830	COG0840	transmembrane signaling receptor activity
HYG86_RS03835	COG0456	acetyltransferase
HYG86_RS03840	COG0488	(ABC) transporter
HYG86_RS03855	COG1028	Short-chain dehydrogenase reductase Sdr
HYG86_RS03865	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HYG86_RS03890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_RS03895	COG0561	phosphatase activity
HYG86_RS03900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_RS03905	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_RS03915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYG86_RS03920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYG86_RS03930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_RS03935	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_RS03940	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HYG86_RS03940	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HYG86_RS03940	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HYG86_RS03940	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HYG86_RS03945	COG1486	melibiose metabolic process
HYG86_RS03950	COG1447	Phosphotransferase system cellobiose-specific component IIA
HYG86_RS03955	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_RS03960	COG1486	melibiose metabolic process
HYG86_RS03985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYG86_RS03990	COG0561	phosphatase activity
HYG86_RS04005	COG4656	Part of a membrane complex involved in electron transport
HYG86_RS04020	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HYG86_RS04035	COG4869	propanediol catabolic process
HYG86_RS04085	COG4753	response regulator
HYG86_RS04085	COG2207	Transcriptional regulator
HYG86_RS04090	COG2972	Histidine kinase
HYG86_RS04110	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYG86_RS04110	COG1902	pentaerythritol trinitrate reductase activity
HYG86_RS04120	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HYG86_RS04135	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYG86_RS04140	COG1129	ABC transporter
HYG86_RS04145	COG1609	Transcriptional regulator
HYG86_RS04150	COG4214	carbohydrate transport
HYG86_RS04160	COG4213	ABC transporter substrate-binding protein
HYG86_RS04165	COG4213	ABC transporter substrate-binding protein
HYG86_RS04170	COG2207	Transcriptional regulator
HYG86_RS04170	COG4753	response regulator
HYG86_RS04175	COG3275	phosphorelay sensor kinase activity
HYG86_RS04200	COG0768	penicillin binding
HYG86_RS04230	COG4536	flavin adenine dinucleotide binding
HYG86_RS04260	COG1940	carbohydrate kinase activity
HYG86_RS04265	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYG86_RS04275	COG1278	Cold shock
HYG86_RS04280	COG1278	Cold shock
HYG86_RS04285	COG0110	maltose O-acetyltransferase activity
HYG86_RS04290	COG3711	transcriptional antiterminator
HYG86_RS04295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYG86_RS04295	COG2190	(PTS) system
HYG86_RS04295	COG1263	PTS System
HYG86_RS04305	COG3870	Protein conserved in bacteria
HYG86_RS04320	COG1737	Transcriptional regulator
HYG86_RS04325	COG2723	6-phospho-beta-galactosidase activity
HYG86_RS04330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_RS04345	COG1595	DNA-templated transcription, initiation
HYG86_RS04355	COG3708	Transcriptional regulator
HYG86_RS04355	COG2207	Transcriptional regulator
HYG86_RS04380	COG0561	phosphatase activity
HYG86_RS04390	COG1408	metallophosphoesterase
HYG86_RS04405	COG5002	protein histidine kinase activity
HYG86_RS04410	COG0745	RESPONSE REGULATOR receiver
HYG86_RS04420	COG2801	Transposase and inactivated derivatives
HYG86_RS04425	COG3328	transposase activity
HYG86_RS04440	COG5002	protein histidine kinase activity
HYG86_RS04475	COG4279	zinc finger
HYG86_RS04480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYG86_RS04485	COG1406	Chemotaxis phosphatase CheX
HYG86_RS04500	COG0135	phosphoribosylanthranilate isomerase activity
HYG86_RS04505	COG0135	phosphoribosylanthranilate isomerase activity
HYG86_RS04525	COG3328	transposase activity
HYG86_RS04555	COG3328	transposase activity
HYG86_RS04580	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HYG86_RS04585	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HYG86_RS04590	COG0732	type I restriction modification DNA specificity domain
HYG86_RS04610	COG1121	(ABC) transporter
HYG86_RS04670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG86_RS04670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG86_RS04765	COG1802	Transcriptional regulator
HYG86_RS04765	COG4626	Terminase
HYG86_RS04770	COG4695	Portal protein
HYG86_RS04965	COG0456	acetyltransferase
HYG86_RS04990	COG3173	Aminoglycoside phosphotransferase
HYG86_RS04995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYG86_RS05025	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG86_RS05050	COG0789	Transcriptional regulator
HYG86_RS05070	COG3708	Transcriptional regulator
HYG86_RS05070	COG2207	Transcriptional regulator
HYG86_RS05090	COG5658	integral membrane protein
HYG86_RS05120	COG0488	(ABC) transporter
HYG86_RS05130	COG0840	transmembrane signaling receptor activity
HYG86_RS05140	COG5646	InterPro IPR014922
HYG86_RS05150	COG1131	(ABC) transporter
HYG86_RS05190	COG1595	DNA-templated transcription, initiation
HYG86_RS05200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HYG86_RS05205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYG86_RS05215	COG1368	sulfuric ester hydrolase activity
HYG86_RS05275	COG1070	Carbohydrate kinase
HYG86_RS05280	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HYG86_RS05315	COG1307	EDD domain protein, DegV family
HYG86_RS05325	COG2801	Transposase and inactivated derivatives
HYG86_RS05355	COG1668	transmembrane transport
HYG86_RS05360	COG4152	abc transporter atp-binding protein
HYG86_RS05385	COG1120	ATPase activity
HYG86_RS05390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG86_RS05395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG86_RS05400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYG86_RS05445	COG3655	Transcriptional regulator
HYG86_RS05470	COG3708	Transcriptional regulator
HYG86_RS05470	COG2207	Transcriptional regulator
HYG86_RS05475	COG0840	transmembrane signaling receptor activity
HYG86_RS05490	COG0450	alkyl hydroperoxide reductase
HYG86_RS05500	COG1357	PFAM Pentapeptide repeats (8 copies)
HYG86_RS05515	COG0431	NADPH-dependent FMN reductase
HYG86_RS05515	COG3976	FMN-binding domain protein
HYG86_RS05515	COG1053	succinate dehydrogenase
HYG86_RS05520	COG1309	transcriptional regulator
HYG86_RS05545	COG4604	ABC transporter, ATP-binding protein
HYG86_RS05550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG86_RS05560	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HYG86_RS05565	COG0375	protein maturation
HYG86_RS05590	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HYG86_RS05605	COG1177	transmembrane transport
HYG86_RS05610	COG1176	ABC-type spermidine putrescine transport system, permease component I
HYG86_RS05615	COG3842	ATPase activity
HYG86_RS05640	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HYG86_RS05670	COG3153	acetyltransferase
HYG86_RS05675	COG0084	hydrolase, TatD family'
HYG86_RS05680	COG2378	regulation of single-species biofilm formation
HYG86_RS05705	COG1982	Orn Lys Arg decarboxylase major
HYG86_RS05785	COG3328	transposase activity
HYG86_RS05825	COG5002	protein histidine kinase activity
HYG86_RS05830	COG0745	RESPONSE REGULATOR receiver
HYG86_RS05835	COG1136	(ABC) transporter
HYG86_RS05840	COG0577	efflux transmembrane transporter activity
HYG86_RS05850	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYG86_RS05855	COG1301	dicarboxylic acid transport
HYG86_RS05870	COG1395	domain, Protein
HYG86_RS05920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HYG86_RS06025	COG4974	Belongs to the 'phage' integrase family
HYG86_RS06035	COG4974	Belongs to the 'phage' integrase family
HYG86_RS06085	COG2801	Transposase and inactivated derivatives
HYG86_RS06120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HYG86_RS06125	COG0557	exoribonuclease II activity
HYG86_RS06140	COG0288	reversible hydration of carbon dioxide
HYG86_RS06150	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HYG86_RS06155	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYG86_RS06170	COG0148	phosphopyruvate hydratase activity
HYG86_RS06175	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HYG86_RS06180	COG0149	triose-phosphate isomerase activity
HYG86_RS06185	COG0126	phosphoglycerate kinase activity
HYG86_RS06195	COG2390	Transcriptional regulator
HYG86_RS06205	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HYG86_RS06210	COG0254	rRNA binding
HYG86_RS06215	COG1481	regulation of sporulation
HYG86_RS06220	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HYG86_RS06235	COG1940	carbohydrate kinase activity
HYG86_RS06255	COG1307	EDD domain protein, DegV family
HYG86_RS06260	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HYG86_RS06265	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HYG86_RS06270	COG3639	organic phosphonate transmembrane transporter activity
HYG86_RS06275	COG3118	belongs to the thioredoxin family
HYG86_RS06290	COG1653	transport
HYG86_RS06310	COG0438	transferase activity, transferring glycosyl groups
HYG86_RS06315	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HYG86_RS06320	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HYG86_RS06330	COG2801	Transposase and inactivated derivatives
HYG86_RS06340	COG1950	PFAM Membrane protein of
HYG86_RS06350	COG2340	Cysteine-rich secretory protein family
HYG86_RS06360	COG2197	response regulator
HYG86_RS06380	COG0390	transport system, permease component
HYG86_RS06385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HYG86_RS06390	COG4608	Belongs to the ABC transporter superfamily
HYG86_RS06395	COG0444	Belongs to the ABC transporter superfamily
HYG86_RS06400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG86_RS06410	COG0747	negative chemotaxis
HYG86_RS06420	COG1132	(ABC) transporter
HYG86_RS06425	COG1132	(ABC) transporter
HYG86_RS06460	COG0322	excinuclease ABC activity
HYG86_RS06465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYG86_RS06470	COG0556	nucleotide-excision repair
HYG86_RS06480	COG0793	Belongs to the peptidase S41A family
HYG86_RS06480	COG3409	Peptidoglycan-binding domain 1 protein
HYG86_RS06485	COG0739	heme binding
HYG86_RS06485	COG0741	lytic transglycosylase activity
HYG86_RS06485	COG1196	nuclear chromosome segregation
HYG86_RS06490	COG2177	Part of the ABC transporter FtsEX involved in
HYG86_RS06495	COG2884	Cell division ATP-binding protein ftsE
HYG86_RS06505	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HYG86_RS06505	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HYG86_RS06515	COG3958	Transketolase
HYG86_RS06520	COG3959	Transketolase, thiamine diphosphate binding domain
HYG86_RS06525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYG86_RS06540	COG0653	protein targeting
HYG86_RS06550	COG1983	PspC domain protein
HYG86_RS06560	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HYG86_RS06565	COG0840	transmembrane signaling receptor activity
HYG86_RS06575	COG0438	transferase activity, transferring glycosyl groups
HYG86_RS06580	COG0463	Glycosyl transferase, family 2
HYG86_RS06580	COG0457	Tetratricopeptide repeat
HYG86_RS06590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG86_RS06595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG86_RS06605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HYG86_RS06610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HYG86_RS06620	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HYG86_RS06625	COG1334	flagellar protein FlaG
HYG86_RS06640	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HYG86_RS06645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG86_RS06650	COG1256	bacterial-type flagellum assembly
HYG86_RS06650	COG4786	Flagellar basal body rod
HYG86_RS06660	COG2747	anti-sigma28 factor FlgM
HYG86_RS06670	COG1040	competence protein
HYG86_RS06695	COG2199	diguanylate cyclase activity
HYG86_RS06695	COG2203	Gaf domain
HYG86_RS06700	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYG86_RS06700	COG2199	diguanylate cyclase activity
HYG86_RS06705	COG0463	Glycosyl transferase, family 2
HYG86_RS06710	COG2197	response regulator
HYG86_RS06715	COG4585	Histidine kinase
HYG86_RS06720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYG86_RS06725	COG0561	phosphatase activity
HYG86_RS06730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYG86_RS06735	COG2707	UPF0756 membrane protein
HYG86_RS06745	COG1473	amidohydrolase
HYG86_RS06750	COG1592	Rubrerythrin
HYG86_RS06750	COG1773	rubredoxin
HYG86_RS06755	COG1592	Rubrerythrin
HYG86_RS06780	COG0814	amino acid
HYG86_RS06785	COG0697	spore germination
HYG86_RS06790	COG1597	lipid kinase activity
HYG86_RS06805	COG0697	spore germination
HYG86_RS06815	COG1121	(ABC) transporter
HYG86_RS06820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYG86_RS06860	COG0697	spore germination
HYG86_RS06865	COG0436	Aminotransferase
HYG86_RS06875	COG1164	Oligoendopeptidase f
HYG86_RS06880	COG1773	rubredoxin
HYG86_RS06895	COG1131	(ABC) transporter
HYG86_RS06900	COG0561	phosphatase activity
HYG86_RS06905	COG0745	RESPONSE REGULATOR receiver
HYG86_RS06910	COG5002	protein histidine kinase activity
HYG86_RS06920	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HYG86_RS06920	COG0617	tRNA 3'-terminal CCA addition
HYG86_RS06920	COG0517	IMP dehydrogenase activity
HYG86_RS06930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYG86_RS06940	COG0668	transmembrane transport
HYG86_RS06945	COG1489	DNA binding
HYG86_RS06955	COG0488	(ABC) transporter
HYG86_RS06965	COG0438	transferase activity, transferring glycosyl groups
HYG86_RS06985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HYG86_RS06990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HYG86_RS06995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HYG86_RS07000	COG0456	acetyltransferase
HYG86_RS07005	COG1214	PFAM Peptidase M22, glycoprotease
HYG86_RS07010	COG0802	atpase or kinase
HYG86_RS07060	COG1404	Belongs to the peptidase S8 family
HYG86_RS07065	COG1162	GTPase activity
HYG86_RS07070	COG0588	phosphoglycerate mutase activity
HYG86_RS07090	COG0402	S-adenosylhomocysteine deaminase activity
HYG86_RS07095	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HYG86_RS07105	COG2183	response to ionizing radiation
HYG86_RS07110	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYG86_RS07125	COG2337	Toxic component of a toxin-antitoxin (TA) module
HYG86_RS07130	COG0864	Transcriptional regulator
HYG86_RS07135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HYG86_RS07145	COG0517	IMP dehydrogenase activity
HYG86_RS07145	COG0617	tRNA 3'-terminal CCA addition
HYG86_RS07145	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HYG86_RS07150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HYG86_RS07150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HYG86_RS07165	COG1505	serine-type exopeptidase activity
HYG86_RS07170	COG0488	(ABC) transporter
HYG86_RS07180	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYG86_RS07190	COG0367	asparagine synthase
HYG86_RS07205	COG2362	D-Aminopeptidase
HYG86_RS07215	COG1136	(ABC) transporter
HYG86_RS07225	COG1595	DNA-templated transcription, initiation
HYG86_RS07235	COG0667	Aldo Keto reductase
HYG86_RS07240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYG86_RS07245	COG1876	peptidase activity
HYG86_RS07255	COG2205	protein histidine kinase activity
HYG86_RS07285	COG2197	response regulator
HYG86_RS07315	COG2197	response regulator
HYG86_RS07330	COG1929	Belongs to the glycerate kinase type-1 family
HYG86_RS07335	COG1132	(ABC) transporter
HYG86_RS07340	COG1132	(ABC) transporter
HYG86_RS07360	COG0006	proline dipeptidase activity
HYG86_RS07365	COG0406	alpha-ribazole phosphatase activity
HYG86_RS07370	COG4464	protein tyrosine phosphatase activity
HYG86_RS07400	COG2267	carboxylic ester hydrolase activity
HYG86_RS07445	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYG86_RS07460	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HYG86_RS07465	COG2217	Heavy metal translocating P-type atpase
HYG86_RS07470	COG0640	Transcriptional regulator
HYG86_RS07490	COG0170	dolichyl monophosphate biosynthetic process
HYG86_RS07510	COG1940	carbohydrate kinase activity
HYG86_RS07515	COG2723	6-phospho-beta-galactosidase activity
HYG86_RS07520	COG3394	polysaccharide catabolic process
HYG86_RS07525	COG1447	Phosphotransferase system cellobiose-specific component IIA
HYG86_RS07530	COG1486	melibiose metabolic process
HYG86_RS07540	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_RS07545	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_RS07550	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HYG86_RS07550	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HYG86_RS07555	COG0019	diaminopimelate decarboxylase activity
HYG86_RS07560	COG2715	membrane protein required for spore maturation
HYG86_RS07565	COG0700	Nucleoside recognition
HYG86_RS07570	COG1619	proteins homologs of microcin C7 resistance protein MccF
HYG86_RS07575	COG1473	amidohydrolase
HYG86_RS07580	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYG86_RS07585	COG1482	cell wall glycoprotein biosynthetic process
HYG86_RS07590	COG0673	inositol 2-dehydrogenase activity
HYG86_RS07600	COG4536	flavin adenine dinucleotide binding
HYG86_RS07620	COG0789	Transcriptional regulator
HYG86_RS07630	COG1846	Transcriptional regulator
HYG86_RS07650	COG0577	efflux transmembrane transporter activity
HYG86_RS07650	COG1136	(ABC) transporter
HYG86_RS07685	COG1151	hydroxylamine reductase activity
HYG86_RS07695	COG5566	PFAM Mor transcription activator
HYG86_RS07700	COG0653	protein targeting
HYG86_RS07715	COG0564	pseudouridine synthase activity
HYG86_RS07735	COG1408	metallophosphoesterase
HYG86_RS07745	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HYG86_RS07760	COG1136	(ABC) transporter
HYG86_RS07765	COG1115	amino acid carrier protein
HYG86_RS07785	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HYG86_RS07795	COG1757	Na H antiporter
HYG86_RS07810	COG5002	protein histidine kinase activity
HYG86_RS07820	COG2721	sulfolactate sulfo-lyase activity
HYG86_RS07825	COG2721	sulfolactate sulfo-lyase activity
HYG86_RS07840	COG1131	(ABC) transporter
HYG86_RS07855	COG0006	proline dipeptidase activity
HYG86_RS07860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HYG86_RS07865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HYG86_RS07870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HYG86_RS07875	COG1473	amidohydrolase
HYG86_RS07880	COG1414	Transcriptional regulator
HYG86_RS07915	COG0778	Nitroreductase
HYG86_RS07925	COG1307	EDD domain protein, DegV family
HYG86_RS07930	COG1063	alcohol dehydrogenase
HYG86_RS07940	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYG86_RS07940	COG2213	PTS system mannitol-specific
HYG86_RS07945	COG3711	transcriptional antiterminator
HYG86_RS07990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYG86_RS07995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYG86_RS08000	COG4856	YbbR-like protein
HYG86_RS08005	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HYG86_RS08030	COG2235	arginine
HYG86_RS08035	COG0010	Belongs to the arginase family
HYG86_RS08040	COG3457	Alanine racemase
HYG86_RS08050	COG5012	cobalamin binding
HYG86_RS08075	COG3829	transcription factor binding
HYG86_RS08080	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HYG86_RS08085	COG0697	spore germination
HYG86_RS08100	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG86_RS08105	COG3973	AAA domain
HYG86_RS08120	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HYG86_RS08125	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HYG86_RS08130	COG0101	tRNA pseudouridine synthase activity
HYG86_RS08135	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HYG86_RS08140	COG1122	ATPase activity
HYG86_RS08145	COG1122	ATPase activity
HYG86_RS08155	COG0202	RNA polymerase activity
HYG86_RS08160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYG86_RS08170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HYG86_RS08175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HYG86_RS08190	COG0024	Methionine aminopeptidase
HYG86_RS08195	COG0563	adenylate kinase activity
HYG86_RS08200	COG0201	protein transport
HYG86_RS08210	COG1841	ribosomal large subunit assembly
HYG86_RS08215	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HYG86_RS08220	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HYG86_RS08225	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HYG86_RS08230	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HYG86_RS08235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYG86_RS08240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HYG86_RS08245	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HYG86_RS08255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HYG86_RS08260	COG0255	Belongs to the universal ribosomal protein uL29 family
HYG86_RS08265	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HYG86_RS08270	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HYG86_RS08280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HYG86_RS08290	COG0089	rRNA binding
HYG86_RS08295	COG0088	Forms part of the polypeptide exit tunnel
HYG86_RS08300	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HYG86_RS08305	COG0051	transcription antitermination factor activity, RNA binding
HYG86_RS08310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYG86_RS08315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYG86_RS08320	COG0049	tRNA binding
HYG86_RS08325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HYG86_RS08330	COG1358	cellular component organization or biogenesis
HYG86_RS08335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HYG86_RS08340	COG0085	RNA polymerase activity
HYG86_RS08350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HYG86_RS08355	COG0081	regulation of translation
HYG86_RS08360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HYG86_RS08365	COG0250	Participates in transcription elongation, termination and antitermination
HYG86_RS08370	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYG86_RS08375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYG86_RS08380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYG86_RS08415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYG86_RS08425	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HYG86_RS08430	COG0215	cysteine-tRNA ligase activity
HYG86_RS08435	COG1045	serine acetyltransferase
HYG86_RS08440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYG86_RS08450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HYG86_RS08455	COG4956	integral membrane protein (PIN domain superfamily)
HYG86_RS08460	COG1329	Transcriptional regulator
HYG86_RS08470	COG1183	phosphatidylcholine synthase activity
HYG86_RS08475	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HYG86_RS08480	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HYG86_RS08490	COG0542	response to heat
HYG86_RS08495	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HYG86_RS08500	COG3880	PFAM UvrB UvrC protein
HYG86_RS08515	COG1126	abc transporter atp-binding protein
HYG86_RS08520	COG0765	amino acid transport
HYG86_RS08525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYG86_RS08535	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HYG86_RS08540	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HYG86_RS08610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HYG86_RS08615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYG86_RS08620	COG5322	oxidoreductase activity
HYG86_RS08620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYG86_RS08635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYG86_RS08650	COG1832	CoA-binding protein
HYG86_RS08660	COG0393	Putative heavy-metal-binding
HYG86_RS08670	COG1131	(ABC) transporter
HYG86_RS08675	COG1725	Transcriptional regulator
HYG86_RS08680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYG86_RS08685	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HYG86_RS08690	COG0157	Belongs to the NadC ModD family
HYG86_RS08695	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HYG86_RS08700	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HYG86_RS08710	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HYG86_RS08715	COG1228	amidohydrolase
HYG86_RS08725	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HYG86_RS08730	COG2986	histidine ammonia-lyase
HYG86_RS08735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYG86_RS08740	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HYG86_RS08745	COG0037	tRNA processing
HYG86_RS08780	COG1098	S1 RNA binding domain
HYG86_RS08800	COG2385	sporulation resulting in formation of a cellular spore
HYG86_RS08805	COG0776	regulation of translation
HYG86_RS08810	COG3956	TIGRFAM MazG family protein
HYG86_RS08815	COG2244	polysaccharide biosynthetic process
HYG86_RS08820	COG2002	toxin-antitoxin pair type II binding
HYG86_RS08830	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HYG86_RS08840	COG0516	GMP reductase activity
HYG86_RS08840	COG0517	IMP dehydrogenase activity
HYG86_RS08845	COG0193	aminoacyl-tRNA hydrolase activity
HYG86_RS08850	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYG86_RS08855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYG86_RS08860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HYG86_RS08865	COG2088	sporulation resulting in formation of a cellular spore
HYG86_RS08870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HYG86_RS08875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYG86_RS08885	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HYG86_RS08890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYG86_RS08890	COG0189	ligase activity
HYG86_RS08905	COG1376	ErfK ybiS ycfS ynhG family protein
HYG86_RS08910	COG2340	Cysteine-rich secretory protein family
HYG86_RS08925	COG4466	Protein conserved in bacteria
HYG86_RS08930	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG86_RS08950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HYG86_RS08955	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HYG86_RS08960	COG0084	hydrolase, TatD family'
HYG86_RS08965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG86_RS08965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG86_RS08985	COG2002	toxin-antitoxin pair type II binding
HYG86_RS08990	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HYG86_RS08995	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HYG86_RS09000	COG4467	Involved in initiation control of chromosome replication
HYG86_RS09005	COG1774	PSP1 C-terminal conserved region
HYG86_RS09015	COG3870	Protein conserved in bacteria
HYG86_RS09025	COG1982	Orn Lys Arg decarboxylase major
HYG86_RS09045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYG86_RS09175	COG5484	DNA packaging
HYG86_RS09175	COG3728	DNA packaging
HYG86_RS09230	COG0629	single-stranded DNA binding
HYG86_RS09235	COG3584	3D domain protein
HYG86_RS09235	COG1388	LysM domain
HYG86_RS09345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYG86_RS09350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYG86_RS09360	COG0517	IMP dehydrogenase activity
HYG86_RS09360	COG0516	GMP reductase activity
HYG86_RS09400	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYG86_RS09430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HYG86_RS09435	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HYG86_RS09440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYG86_RS09480	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HYG86_RS09485	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HYG86_RS09490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYG86_RS09505	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HYG86_RS09510	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYG86_RS09510	COG1328	CTP reductase activity
HYG86_RS09515	COG0602	queuosine metabolic process
HYG86_RS09540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYG86_RS09545	COG0187	DNA topoisomerase II activity
HYG86_RS09560	COG2501	S4 domain
HYG86_RS09565	COG0592	DNA-directed DNA polymerase activity
HYG86_RS09570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HYG86_RS09575	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HYG86_RS09580	COG0594	ribonuclease P activity
HYG86_RS09590	COG0706	membrane insertase activity
HYG86_RS09595	COG1847	R3H domain protein
HYG86_RS09600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HYG86_RS09605	COG0445	tRNA wobble uridine modification
HYG86_RS09610	COG0357	Ribosomal RNA small subunit methyltransferase G
HYG86_RS09620	COG1192	Involved in chromosome partitioning
HYG86_RS09625	COG1475	DNA binding
HYG86_RS09635	COG1811	Na channel or pump
HYG86_RS09640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HYG86_RS09655	COG0739	heme binding
HYG86_RS09655	COG1196	nuclear chromosome segregation
HYG86_RS09655	COG0741	lytic transglycosylase activity
HYG86_RS09675	COG3949	Membrane
HYG86_RS09705	COG4481	Protein conserved in bacteria
HYG86_RS09710	COG0360	Binds together with S18 to 16S ribosomal RNA
HYG86_RS09715	COG0629	single-stranded DNA binding
HYG86_RS09720	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYG86_RS09740	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYG86_RS09750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HYG86_RS09775	COG1283	sodium-dependent phosphate transmembrane transporter activity
HYG86_RS09780	COG0791	NLP P60 protein
HYG86_RS09780	COG1388	LysM domain
HYG86_RS09790	COG0745	RESPONSE REGULATOR receiver
HYG86_RS09795	COG5002	protein histidine kinase activity
HYG86_RS09805	COG4853	Protein conserved in bacteria
HYG86_RS09815	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HYG86_RS09820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYG86_RS09835	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HYG86_RS09870	COG2226	methyltransferase
HYG86_RS09890	COG5002	protein histidine kinase activity
HYG86_RS09895	COG0745	RESPONSE REGULATOR receiver
HYG86_RS09905	COG1309	transcriptional regulator
HYG86_RS09910	COG2814	Major facilitator Superfamily
HYG86_RS09930	COG0017	Asparaginyl-tRNA synthetase
HYG86_RS09940	COG3708	Transcriptional regulator
HYG86_RS09940	COG2207	Transcriptional regulator
HYG86_RS09945	COG1132	(ABC) transporter
HYG86_RS09950	COG1132	(ABC) transporter
HYG86_RS09960	COG2226	methyltransferase
HYG86_RS09965	COG2884	Cell division ATP-binding protein ftsE
HYG86_RS09970	COG2177	Part of the ABC transporter FtsEX involved in
HYG86_RS09985	COG0673	inositol 2-dehydrogenase activity
HYG86_RS10000	COG0514	ATP-dependent DNA helicase (RecQ)
HYG86_RS10010	COG0534	Mate efflux family protein
HYG86_RS10015	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYG86_RS10020	COG2706	6-phosphogluconolactonase activity
HYG86_RS10045	COG4286	Uncharacterised protein family (UPF0160)
HYG86_RS10050	COG1132	(ABC) transporter
HYG86_RS10055	COG1132	(ABC) transporter
HYG86_RS10060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYG86_RS10085	COG3871	stress protein (general stress protein 26)
HYG86_RS10090	COG2814	Major facilitator Superfamily
HYG86_RS10100	COG0488	(ABC) transporter
HYG86_RS10110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYG86_RS10110	COG0723	plastoquinol--plastocyanin reductase activity
HYG86_RS10120	COG1187	pseudouridine synthase activity
HYG86_RS10125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYG86_RS10125	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HYG86_RS10145	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYG86_RS10170	COG2323	membrane
HYG86_RS10190	COG1151	hydroxylamine reductase activity
HYG86_RS10205	COG1902	pentaerythritol trinitrate reductase activity
HYG86_RS10210	COG0420	3'-5' exonuclease activity
HYG86_RS10215	COG4717	serine-type aminopeptidase activity
HYG86_RS10220	COG0423	glycine-tRNA ligase activity
HYG86_RS10230	COG0114	fumarate hydratase activity
HYG86_RS10235	COG1199	ATP-dependent helicase activity
HYG86_RS10245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYG86_RS10250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYG86_RS10260	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYG86_RS10265	COG0010	Belongs to the arginase family
HYG86_RS10280	COG3829	transcription factor binding
HYG86_RS10285	COG0604	alcohol dehydrogenase
HYG86_RS10300	COG1193	negative regulation of DNA recombination
HYG86_RS10305	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HYG86_RS10310	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG86_RS10315	COG0504	CTP synthase activity
HYG86_RS10325	COG2204	response regulator
HYG86_RS10330	COG1494	fructose-1,6-bisphosphatase
HYG86_RS10335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYG86_RS10340	COG1494	fructose-1,6-bisphosphatase
HYG86_RS10345	COG0530	calcium, potassium:sodium antiporter activity
HYG86_RS10350	COG4942	peptidase
HYG86_RS10370	COG1435	thymidine kinase activity
HYG86_RS10375	COG3872	metal-dependent enzyme
HYG86_RS10380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HYG86_RS10385	COG2890	protein-(glutamine-N5) methyltransferase activity
HYG86_RS10390	COG1191	sigma factor activity
HYG86_RS10400	COG2801	Transposase and inactivated derivatives
HYG86_RS10410	COG1959	2 iron, 2 sulfur cluster binding
HYG86_RS10415	COG1104	cysteine desulfurase activity
HYG86_RS10420	COG0822	iron-sulfur transferase activity
HYG86_RS10430	COG0425	Belongs to the sulfur carrier protein TusA family
HYG86_RS10445	COG1283	sodium-dependent phosphate transmembrane transporter activity
HYG86_RS10450	COG0735	belongs to the Fur family
HYG86_RS10460	COG0009	L-threonylcarbamoyladenylate synthase
HYG86_RS10465	COG1971	Probably functions as a manganese efflux pump
HYG86_RS10475	COG0840	transmembrane signaling receptor activity
HYG86_RS10480	COG0698	ribose 5-phosphate isomerase
HYG86_RS10485	COG4475	Protein of unknown function (DUF436)
HYG86_RS10490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HYG86_RS10495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HYG86_RS10515	COG1607	acyl-coa hydrolase
HYG86_RS10520	COG3246	L-lysine catabolic process to acetate
HYG86_RS10545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HYG86_RS10550	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYG86_RS10555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HYG86_RS10560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HYG86_RS10565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HYG86_RS10570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HYG86_RS10575	COG5506	Protein of unknown function (DUF1694)
HYG86_RS10585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYG86_RS10590	COG2385	sporulation resulting in formation of a cellular spore
HYG86_RS10600	COG1609	Transcriptional regulator
HYG86_RS10670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYG86_RS10680	COG1496	oxidoreductase activity
HYG86_RS10685	COG0251	oxidation-reduction process
HYG86_RS10690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYG86_RS10700	COG3275	phosphorelay sensor kinase activity
HYG86_RS10705	COG3279	Response regulator of the LytR AlgR family
HYG86_RS10710	COG1966	Carbon starvation protein
HYG86_RS10725	COG3118	belongs to the thioredoxin family
HYG86_RS10760	COG2801	Transposase and inactivated derivatives
HYG86_RS10765	COG0426	domain, Protein
HYG86_RS10790	COG0583	DNA-binding transcription factor activity
HYG86_RS10795	COG0709	Synthesizes selenophosphate from selenide and ATP
HYG86_RS10805	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HYG86_RS10825	COG0303	'Molybdopterin
HYG86_RS10830	COG1910	domain protein
HYG86_RS10835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HYG86_RS10840	COG0459	protein refolding
HYG86_RS10845	COG0714	Associated with various cellular activities
HYG86_RS10850	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HYG86_RS10880	COG2801	Transposase and inactivated derivatives
HYG86_RS10895	COG3177	Filamentation induced by cAMP protein fic
HYG86_RS10950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HYG86_RS10955	COG2252	PERMEase
HYG86_RS10960	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HYG86_RS10965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HYG86_RS10970	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYG86_RS10975	COG0047	phosphoribosylformylglycinamidine synthase activity
HYG86_RS10980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYG86_RS10985	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HYG86_RS10990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HYG86_RS10995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HYG86_RS11000	COG0138	bifunctional purine biosynthesis protein purh
HYG86_RS11005	COG0151	Belongs to the GarS family
HYG86_RS11030	COG0534	Mate efflux family protein
HYG86_RS11040	COG3290	protein histidine kinase activity
HYG86_RS11040	COG3829	transcription factor binding
HYG86_RS11060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYG86_RS11070	COG2376	Dihydroxyacetone kinase
HYG86_RS11080	COG1233	COG1233 Phytoene dehydrogenase and related
HYG86_RS11085	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HYG86_RS11105	COG1592	Rubrerythrin
HYG86_RS11105	COG1773	rubredoxin
HYG86_RS11120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HYG86_RS11130	COG4496	protein, YerC YecD
HYG86_RS11135	COG1454	alcohol dehydrogenase
HYG86_RS11145	COG0210	DNA helicase
HYG86_RS11150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYG86_RS11180	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HYG86_RS11200	COG5002	protein histidine kinase activity
HYG86_RS11205	COG1136	(ABC) transporter
HYG86_RS11220	COG1028	Short-chain dehydrogenase reductase Sdr
HYG86_RS11225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYG86_RS11265	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HYG86_RS11270	COG0363	glucosamine-6-phosphate deaminase activity
HYG86_RS11275	COG1737	Transcriptional regulator
HYG86_RS11285	COG1263	PTS System
HYG86_RS11285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYG86_RS11310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HYG86_RS11315	COG4974	Belongs to the 'phage' integrase family
HYG86_RS11415	COG1937	Protein conserved in bacteria
HYG86_RS11420	COG2217	Heavy metal translocating P-type atpase
HYG86_RS11460	COG0534	Mate efflux family protein
HYG86_RS11465	COG1937	Protein conserved in bacteria
HYG86_RS11470	COG1136	(ABC) transporter
HYG86_RS11475	COG0577	efflux transmembrane transporter activity
HYG86_RS11525	COG0783	Belongs to the Dps family
HYG86_RS11530	COG3620	sequence-specific DNA binding
HYG86_RS11550	COG1132	(ABC) transporter
HYG86_RS11570	COG3848	Pyruvate phosphate dikinase
HYG86_RS11570	COG0574	Belongs to the PEP-utilizing enzyme family
HYG86_RS11575	COG0488	(ABC) transporter
HYG86_RS11605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYG86_RS11610	COG0805	protein transport
HYG86_RS11615	COG3976	FMN-binding domain protein
HYG86_RS11615	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HYG86_RS11620	COG2391	methyltransferase activity
HYG86_RS11630	COG2391	methyltransferase activity
HYG86_RS11635	COG0583	DNA-binding transcription factor activity
HYG86_RS11660	COG0493	'glutamate synthase
HYG86_RS11665	COG3279	Response regulator of the LytR AlgR family
HYG86_RS11690	COG2207	Transcriptional regulator
HYG86_RS11705	COG2207	Transcriptional regulator
HYG86_RS11705	COG3708	Transcriptional regulator
HYG86_RS11715	COG0667	Aldo Keto reductase
HYG86_RS11745	COG3620	sequence-specific DNA binding
HYG86_RS11760	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HYG86_RS11770	COG0813	purine-nucleoside phosphorylase activity
HYG86_RS11775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYG86_RS11780	COG1595	DNA-templated transcription, initiation
HYG86_RS11790	COG1131	(ABC) transporter
HYG86_RS11810	COG0667	Aldo Keto reductase
HYG86_RS11820	COG0656	L-ascorbic acid biosynthetic process
HYG86_RS11830	COG0667	Aldo Keto reductase
HYG86_RS11850	COG1309	transcriptional regulator
HYG86_RS11865	COG0789	Transcriptional regulator
HYG86_RS11870	COG0667	Aldo Keto reductase
HYG86_RS11875	COG2723	6-phospho-beta-galactosidase activity
HYG86_RS11905	COG0484	heat shock protein binding
HYG86_RS11910	COG0840	transmembrane signaling receptor activity
HYG86_RS11915	COG3326	Membrane
HYG86_RS11920	COG3973	AAA domain
HYG86_RS11925	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HYG86_RS11935	COG0346	lactoylglutathione lyase activity
HYG86_RS11945	COG2268	Band 7 protein
HYG86_RS11980	COG4895	conserved protein (DUF2196)
HYG86_RS11990	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HYG86_RS12000	COG1476	TRANSCRIPTIONal
HYG86_RS12025	COG2801	Transposase and inactivated derivatives
HYG86_RS12030	COG0745	RESPONSE REGULATOR receiver
HYG86_RS12045	COG2205	protein histidine kinase activity
HYG86_RS12060	COG4989	oxidoreductase activity
HYG86_RS12080	COG0784	Response regulator, receiver
HYG86_RS12080	COG3437	response regulator, receiver
HYG86_RS12085	COG2169	Transcriptional regulator
HYG86_RS12090	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG86_RS12095	COG4605	iron ion homeostasis
HYG86_RS12100	COG4604	ABC transporter, ATP-binding protein
HYG86_RS12105	COG4607	ABC-type enterochelin transport system periplasmic component
HYG86_RS12110	COG2996	Protein conserved in bacteria
HYG86_RS12125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYG86_RS12160	COG1349	DNA-binding transcription factor activity
HYG86_RS12175	COG0058	SHG alpha-glucan phosphorylase activity
HYG86_RS12190	COG1175	transmembrane transport
HYG86_RS12195	COG3833	ABC-type maltose transport systems, permease component
HYG86_RS12200	COG3842	ATPase activity
HYG86_RS12205	COG1609	Transcriptional regulator
HYG86_RS12225	COG0187	DNA topoisomerase II activity
HYG86_RS12245	COG0385	Bile acid
HYG86_RS12250	COG1132	(ABC) transporter
HYG86_RS12300	COG1309	transcriptional regulator
HYG86_RS12305	COG1131	(ABC) transporter
HYG86_RS12320	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HYG86_RS12350	COG0384	phenazine biosynthesis protein PhzF
HYG86_RS12380	COG0012	GTP binding
HYG86_RS12385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYG86_RS12385	COG1263	PTS System
HYG86_RS12390	COG0366	Alpha amylase catalytic
HYG86_RS12395	COG2188	Transcriptional regulator
HYG86_RS12405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HYG86_RS12410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYG86_RS12415	COG1757	Na H antiporter
HYG86_RS12420	COG2323	membrane
HYG86_RS12430	COG1725	Transcriptional regulator
HYG86_RS12435	COG1131	(ABC) transporter
HYG86_RS12445	COG0753	catalase activity
HYG86_RS12445	COG0693	protein deglycase activity
HYG86_RS12450	COG2832	Protein of unknown function (DUF454)
HYG86_RS12465	COG0626	cystathionine gamma-synthase activity
HYG86_RS12490	COG3875	lactate racemase activity
HYG86_RS12495	COG1464	Belongs to the NlpA lipoprotein family
HYG86_RS12500	COG0436	Aminotransferase
HYG86_RS12505	COG2011	ABC-type metal ion transport system permease component
HYG86_RS12510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HYG86_RS12515	COG2909	trisaccharide binding
HYG86_RS12530	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HYG86_RS12535	COG1757	Na H antiporter
HYG86_RS12560	COG1368	sulfuric ester hydrolase activity
HYG86_RS12565	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HYG86_RS12635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYG86_RS12640	COG1132	(ABC) transporter
HYG86_RS12645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYG86_RS12655	COG4585	Histidine kinase
HYG86_RS12660	COG2197	response regulator
HYG86_RS12665	COG1943	Transposase
HYG86_RS12670	COG1131	(ABC) transporter
HYG86_RS12690	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYG86_RS12715	COG1725	Transcriptional regulator
HYG86_RS12720	COG1131	(ABC) transporter
HYG86_RS12740	COG0488	(ABC) transporter
HYG86_RS12755	COG2966	Psort location CytoplasmicMembrane, score
HYG86_RS12765	COG0116	Belongs to the methyltransferase superfamily
HYG86_RS12790	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HYG86_RS12795	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYG86_RS12795	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYG86_RS12800	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYG86_RS12810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYG86_RS12815	COG0166	Belongs to the GPI family
HYG86_RS12825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYG86_RS12835	COG0584	glycerophosphoryl diester phosphodiesterase
HYG86_RS12840	COG2211	Major facilitator Superfamily
HYG86_RS12845	COG1523	belongs to the glycosyl hydrolase 13 family
HYG86_RS12870	COG2813	Specifically methylates the guanine in position
HYG86_RS12880	COG0564	pseudouridine synthase activity
HYG86_RS12885	COG1615	UPF0182 protein
HYG86_RS12925	COG1136	(ABC) transporter
HYG86_RS12970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYG86_RS12980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYG86_RS12995	COG1278	Cold shock
HYG86_RS13000	COG1595	DNA-templated transcription, initiation
HYG86_RS13020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HYG86_RS13035	COG1739	Uncharacterized protein family UPF0029
HYG86_RS13050	COG0735	belongs to the Fur family
HYG86_RS13060	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HYG86_RS13065	COG0366	Alpha amylase catalytic
HYG86_RS13065	COG1874	Beta-galactosidase
HYG86_RS13070	COG0791	NLP P60 protein
HYG86_RS13070	COG1388	LysM domain
HYG86_RS13070	COG3103	Sh3 type 3 domain protein
HYG86_RS13080	COG4109	DRTGG domain
HYG86_RS13095	COG0688	phosphatidylethanolamine metabolic process
HYG86_RS13110	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HYG86_RS13115	COG0281	malic enzyme
HYG86_RS13155	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYG86_RS13175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG86_RS13185	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYG86_RS13190	COG1028	Short-chain dehydrogenase reductase Sdr
HYG86_RS13195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYG86_RS13205	COG0511	ligase activity, forming carbon-carbon bonds
HYG86_RS13210	COG0439	Biotin carboxylase
HYG86_RS13215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HYG86_RS13220	COG0825	malonyl-CoA metabolic process
HYG86_RS13225	COG0733	neurotransmitter:sodium symporter activity
HYG86_RS13230	COG3679	Belongs to the UPF0342 family
HYG86_RS13240	COG2221	Nitrite and sulphite reductase 4Fe-4S
HYG86_RS13245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYG86_RS13245	COG1522	sequence-specific DNA binding
HYG86_RS13250	COG2313	pseudouridylate synthase activity
HYG86_RS13255	COG0612	Peptidase, M16
HYG86_RS13260	COG0612	Peptidase, M16
HYG86_RS13285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYG86_RS13290	COG1595	DNA-templated transcription, initiation
HYG86_RS13300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG86_RS13300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG86_RS13305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HYG86_RS13310	COG1971	Probably functions as a manganese efflux pump
HYG86_RS13315	COG0237	dephospho-CoA kinase activity
HYG86_RS13320	COG0741	lytic transglycosylase activity
HYG86_RS13335	COG0601	transmembrane transport
HYG86_RS13340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG86_RS13345	COG0444	Belongs to the ABC transporter superfamily
HYG86_RS13350	COG4608	Belongs to the ABC transporter superfamily
HYG86_RS13420	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HYG86_RS13425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HYG86_RS13430	COG0569	domain protein
HYG86_RS13435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYG86_RS13440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HYG86_RS13445	COG0072	phenylalanine-tRNA ligase activity
HYG86_RS13445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG86_RS13455	COG1286	toxin biosynthetic process
HYG86_RS13460	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYG86_RS13460	COG1796	DNA polymerase
HYG86_RS13465	COG1193	negative regulation of DNA recombination
HYG86_RS13470	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HYG86_RS13475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYG86_RS13520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYG86_RS13525	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HYG86_RS13555	COG1683	Conserved Protein
HYG86_RS13560	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYG86_RS13565	COG0217	transcriptional regulatory protein
HYG86_RS13575	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HYG86_RS13585	COG2255	four-way junction helicase activity
HYG86_RS13595	COG1191	sigma factor activity
HYG86_RS13605	COG2247	cell wall binding repeat
HYG86_RS13605	COG2385	sporulation resulting in formation of a cellular spore
HYG86_RS13615	COG0343	queuine tRNA-ribosyltransferase activity
HYG86_RS13620	COG1862	Preprotein translocase
HYG86_RS13645	COG0488	(ABC) transporter
HYG86_RS13650	COG0367	asparagine synthase
HYG86_RS13655	COG2059	Chromate
HYG86_RS13670	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYG86_RS13705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYG86_RS13710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYG86_RS13715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HYG86_RS13715	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HYG86_RS13720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYG86_RS13725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYG86_RS13730	COG1490	D-aminoacyl-tRNA deacylase activity
HYG86_RS13735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYG86_RS13755	COG2801	Transposase and inactivated derivatives
HYG86_RS13765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYG86_RS13770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HYG86_RS13785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYG86_RS13790	COG1757	Na H antiporter
HYG86_RS13800	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HYG86_RS13825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HYG86_RS13835	COG1307	EDD domain protein, DegV family
HYG86_RS13845	COG3839	Belongs to the ABC transporter superfamily
HYG86_RS13865	COG3290	protein histidine kinase activity
HYG86_RS13865	COG3829	transcription factor binding
HYG86_RS13885	COG0183	Belongs to the thiolase family
HYG86_RS13890	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HYG86_RS13900	COG2031	fatty acid transporter
HYG86_RS13920	COG0778	Nitroreductase
HYG86_RS13935	COG0488	(ABC) transporter
HYG86_RS13950	COG2873	o-acetylhomoserine
HYG86_RS13980	COG1840	ABC-type Fe3 transport system, periplasmic component
HYG86_RS13990	COG3842	ATPase activity
HYG86_RS14000	COG3711	transcriptional antiterminator
HYG86_RS14020	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HYG86_RS14035	COG2199	diguanylate cyclase activity
HYG86_RS14050	COG1396	sequence-specific DNA binding
HYG86_RS14055	COG0561	phosphatase activity
HYG86_RS14070	COG3829	transcription factor binding
HYG86_RS14070	COG3290	protein histidine kinase activity
HYG86_RS14080	COG1151	hydroxylamine reductase activity
HYG86_RS14095	COG0024	Methionine aminopeptidase
HYG86_RS14105	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HYG86_RS14115	COG1070	Carbohydrate kinase
HYG86_RS14120	COG1316	TRANSCRIPTIONal
HYG86_RS14130	COG1263	PTS System
HYG86_RS14130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYG86_RS14135	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYG86_RS14150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYG86_RS14165	COG1131	(ABC) transporter
HYG86_RS14170	COG1725	Transcriptional regulator
HYG86_RS14175	COG0628	permease
HYG86_RS14180	COG1253	flavin adenine dinucleotide binding
HYG86_RS14185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYG86_RS14190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYG86_RS14200	COG3037	sugar-specific permease SgaT UlaA
HYG86_RS14205	COG3959	Transketolase, thiamine diphosphate binding domain
HYG86_RS14210	COG3958	Transketolase
HYG86_RS14220	COG2378	regulation of single-species biofilm formation
HYG86_RS14240	COG1131	(ABC) transporter
HYG86_RS14255	COG4585	Histidine kinase
HYG86_RS14260	COG2197	response regulator
HYG86_RS14280	COG1233	COG1233 Phytoene dehydrogenase and related
HYG86_RS14370	COG1131	(ABC) transporter
HYG86_RS14390	COG0251	oxidation-reduction process
HYG86_RS14405	COG2364	Membrane
HYG86_RS14415	COG2361	Protein of unknown function DUF86
HYG86_RS14460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYG86_RS14465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG86_RS14470	COG1120	ATPase activity
HYG86_RS14475	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HYG86_RS14490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HYG86_RS14495	COG0066	3-isopropylmalate dehydratase activity
HYG86_RS14540	COG0840	transmembrane signaling receptor activity
HYG86_RS14550	COG3328	transposase activity
HYG86_RS14555	COG2364	Membrane
HYG86_RS14610	COG0513	Belongs to the DEAD box helicase family
HYG86_RS14680	COG2105	PFAM AIG2 family protein
HYG86_RS14730	COG0484	heat shock protein binding
HYG86_RS14735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYG86_RS14735	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HYG86_RS14760	COG2105	PFAM AIG2 family protein
HYG86_RS14775	COG1131	(ABC) transporter
HYG86_RS14780	COG4585	Histidine kinase
HYG86_RS14785	COG2197	response regulator
HYG86_RS14810	COG1114	Component of the transport system for branched-chain amino acids
HYG86_RS14820	COG0386	Belongs to the glutathione peroxidase family
HYG86_RS14835	COG1131	(ABC) transporter
HYG86_RS14855	COG4585	Histidine kinase
HYG86_RS14860	COG2197	response regulator
HYG86_RS14885	COG0840	transmembrane signaling receptor activity
HYG86_RS14905	COG1151	hydroxylamine reductase activity
HYG86_RS14930	COG3022	response to hydroperoxide
HYG86_RS14935	COG0840	transmembrane signaling receptor activity
HYG86_RS14940	COG0484	heat shock protein binding
HYG86_RS14960	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HYG86_RS14965	COG1131	(ABC) transporter
HYG86_RS14985	COG1309	transcriptional regulator
HYG86_RS14995	COG4555	ABC transporter
HYG86_RS15005	COG4555	ABC transporter
HYG86_RS15020	COG3314	Sporulation integral membrane protein YlbJ
HYG86_RS15050	COG0697	spore germination
HYG86_RS15060	COG1196	nuclear chromosome segregation
HYG86_RS15060	COG0741	lytic transglycosylase activity
HYG86_RS15060	COG0739	heme binding
HYG86_RS15085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYG86_RS15090	COG0840	transmembrane signaling receptor activity
HYG86_RS15120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYG86_RS15125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYG86_RS15130	COG0656	L-ascorbic acid biosynthetic process
HYG86_RS15135	COG0840	transmembrane signaling receptor activity
HYG86_RS15145	COG2081	HI0933 family
HYG86_RS15165	COG1074	ATP-dependent DNA helicase activity
HYG86_RS15190	COG0124	histidyl-tRNA synthetase
HYG86_RS15205	COG1307	EDD domain protein, DegV family
HYG86_RS15230	COG0513	Belongs to the DEAD box helicase family
HYG86_RS15245	COG3409	Peptidoglycan-binding domain 1 protein
HYG86_RS15245	COG3773	Cell wall hydrolase
HYG86_RS15260	COG4260	virion core protein, lumpy skin disease virus
HYG86_RS15275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYG86_RS15300	COG1032	radical SAM domain protein
HYG86_RS15320	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HYG86_RS15330	COG0312	modulator of DNA gyrase
HYG86_RS15335	COG0668	transmembrane transport
HYG86_RS15340	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HYG86_RS15345	COG0534	Mate efflux family protein
HYG86_RS15360	COG1131	(ABC) transporter
HYG86_RS15380	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HYG86_RS15390	COG0778	Nitroreductase
HYG86_RS15395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYG86_RS15400	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYG86_RS15405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYG86_RS15425	COG4191	Histidine kinase
HYG86_RS15430	COG2204	response regulator
HYG86_RS15460	COG0745	RESPONSE REGULATOR receiver
HYG86_RS15465	COG5002	protein histidine kinase activity
HYG86_RS15470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HYG86_RS15480	COG3328	transposase activity
HYG86_RS15505	COG0697	spore germination
HYG86_RS15510	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HYG86_RS15530	COG0628	permease
HYG86_RS15535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYG86_RS15540	COG4472	Bacterial protein of unknown function (DUF965)
HYG86_RS15545	COG0667	Aldo Keto reductase
HYG86_RS15555	COG3906	Belongs to the UPF0473 family
HYG86_RS15560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HYG86_RS15565	COG0826	peptidase U32
HYG86_RS15570	COG0572	uridine kinase
HYG86_RS15575	COG0768	penicillin binding
HYG86_RS15585	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HYG86_RS15595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HYG86_RS15605	COG1459	type II secretion system
HYG86_RS15640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HYG86_RS15650	COG2801	Transposase and inactivated derivatives
HYG86_RS15670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HYG86_RS15680	COG1459	type II secretion system
HYG86_RS15700	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HYG86_RS15740	COG1131	(ABC) transporter
HYG86_RS15755	COG0714	Associated with various cellular activities
HYG86_RS15795	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYG86_RS15805	COG3404	Formiminotransferase-cyclodeaminase
HYG86_RS15820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HYG86_RS15825	COG0509	glycine decarboxylation via glycine cleavage system
HYG86_RS15830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYG86_RS15835	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYG86_RS15840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYG86_RS15845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HYG86_RS15850	COG0006	proline dipeptidase activity
HYG86_RS15855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HYG86_RS15865	COG3854	ATPases associated with a variety of cellular activities
HYG86_RS15905	COG1302	Protein conserved in bacteria
HYG86_RS15925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HYG86_RS15935	COG0493	'glutamate synthase
HYG86_RS15940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HYG86_RS15945	COG1570	exodeoxyribonuclease VII activity
HYG86_RS15950	COG1722	exodeoxyribonuclease VII activity
HYG86_RS15960	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HYG86_RS15970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HYG86_RS15975	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HYG86_RS15985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HYG86_RS15990	COG0497	DNA recombination
HYG86_RS15995	COG0750	zinc metalloprotease
HYG86_RS16000	COG0745	RESPONSE REGULATOR receiver
HYG86_RS16025	COG3829	transcription factor binding
HYG86_RS16025	COG3290	protein histidine kinase activity
HYG86_RS16035	COG3426	butyrate kinase activity
HYG86_RS16040	COG0280	phosphate acetyltransferase
HYG86_RS16050	COG3426	butyrate kinase activity
HYG86_RS16065	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYG86_RS16065	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYG86_RS16080	COG1067	ATP-dependent peptidase activity
HYG86_RS16090	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYG86_RS16100	COG1379	DNA repair
HYG86_RS16105	COG1300	Membrane
HYG86_RS16115	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HYG86_RS16120	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HYG86_RS16125	COG1592	Rubrerythrin
HYG86_RS16135	COG4974	Belongs to the 'phage' integrase family
HYG86_RS16140	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HYG86_RS16150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HYG86_RS16155	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HYG86_RS16160	COG1686	Belongs to the peptidase S11 family
HYG86_RS16170	COG2172	sigma factor antagonist activity
HYG86_RS16190	COG3360	Dodecin
HYG86_RS16200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG86_RS16220	COG0697	spore germination
HYG86_RS16235	COG1924	4 iron, 4 sulfur cluster binding
HYG86_RS16240	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HYG86_RS16240	COG3620	sequence-specific DNA binding
HYG86_RS16240	COG0617	tRNA 3'-terminal CCA addition
HYG86_RS16245	COG1994	Peptidase M50
HYG86_RS16250	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HYG86_RS16255	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HYG86_RS16265	COG3874	Sporulation protein YtfJ
HYG86_RS16270	COG1686	Belongs to the peptidase S11 family
HYG86_RS16275	COG2715	membrane protein required for spore maturation
HYG86_RS16280	COG0700	Nucleoside recognition
HYG86_RS16290	COG0445	tRNA wobble uridine modification
HYG86_RS16300	COG1187	pseudouridine synthase activity
HYG86_RS16305	COG0517	IMP dehydrogenase activity
HYG86_RS16310	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HYG86_RS16315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYG86_RS16315	COG0574	Belongs to the PEP-utilizing enzyme family
HYG86_RS16320	COG1686	Belongs to the peptidase S11 family
HYG86_RS16325	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HYG86_RS16330	COG1671	Belongs to the UPF0178 family
HYG86_RS16360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYG86_RS16380	COG0534	Mate efflux family protein
HYG86_RS16400	COG4224	UPF0291 protein
HYG86_RS16405	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYG86_RS16415	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
HYG86_RS16440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYG86_RS16445	COG0495	leucyl-tRNA aminoacylation
HYG86_RS16455	COG1217	gtp-binding protein TYPA
HYG86_RS16465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYG86_RS16485	COG2385	sporulation resulting in formation of a cellular spore
HYG86_RS16505	COG1141	Ferredoxin
HYG86_RS16515	COG0142	geranyltranstransferase activity
HYG86_RS16530	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HYG86_RS16535	COG0540	Belongs to the ATCase OTCase family
HYG86_RS16550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYG86_RS16555	COG0284	orotidine-5'-phosphate decarboxylase activity
HYG86_RS16560	COG0505	Belongs to the CarA family
HYG86_RS16565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HYG86_RS16570	COG0543	2 iron, 2 sulfur cluster binding
HYG86_RS16575	COG0167	dihydroorotate dehydrogenase activity
HYG86_RS16585	COG1854	S-ribosylhomocysteine lyase activity
HYG86_RS16610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYG86_RS16615	COG2244	polysaccharide biosynthetic process
HYG86_RS16625	COG0492	ferredoxin-NADP+ reductase activity
HYG86_RS16630	COG1363	Peptidase, m42
HYG86_RS16640	COG2323	membrane
HYG86_RS16655	COG1765	OsmC-like protein
HYG86_RS16660	COG1959	2 iron, 2 sulfur cluster binding
HYG86_RS16670	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HYG86_RS16675	COG1937	Protein conserved in bacteria
HYG86_RS16685	COG0785	Cytochrome C biogenesis protein
HYG86_RS16690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HYG86_RS16705	COG2001	Belongs to the MraZ family
HYG86_RS16710	COG0275	rRNA processing
HYG86_RS16720	COG0768	penicillin binding
HYG86_RS16725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYG86_RS16730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYG86_RS16735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYG86_RS16745	COG0772	Belongs to the SEDS family
HYG86_RS16750	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYG86_RS16755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYG86_RS16765	COG3879	Bacterial protein of unknown function (DUF881)
HYG86_RS16770	COG3856	small basic protein
HYG86_RS16775	COG0849	cell division
HYG86_RS16780	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HYG86_RS16790	COG1191	sigma factor activity
HYG86_RS16820	COG1191	sigma factor activity
HYG86_RS16830	COG1873	PFAM PRC-barrel domain
HYG86_RS16835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYG86_RS16845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HYG86_RS16855	COG2302	S4 RNA-binding domain
HYG86_RS16860	COG3599	regulation of cell shape
HYG86_RS16875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HYG86_RS16880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HYG86_RS16885	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HYG86_RS16895	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HYG86_RS16900	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HYG86_RS16905	COG0564	pseudouridine synthase activity
HYG86_RS16910	COG2233	PERMEase
HYG86_RS16920	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HYG86_RS16925	COG1561	YicC-like family, N-terminal region
HYG86_RS16930	COG2052	Domain of unknown function (DUF370)
HYG86_RS16935	COG0194	GDP metabolic process
HYG86_RS16940	COG1758	RNA polymerase activity
HYG86_RS16945	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HYG86_RS16950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HYG86_RS16955	COG0242	peptide deformylase activity
HYG86_RS16960	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HYG86_RS16970	COG2738	Putative neutral zinc metallopeptidase
HYG86_RS16975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYG86_RS16975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYG86_RS16985	COG0631	protein serine/threonine phosphatase activity
HYG86_RS16990	COG2815	serine threonine protein kinase
HYG86_RS16990	COG0515	serine threonine protein kinase
HYG86_RS16995	COG1162	GTPase activity
HYG86_RS17000	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYG86_RS17010	COG3859	Proton-coupled thiamine transporter YuaJ
HYG86_RS17020	COG0622	Phosphoesterase
HYG86_RS17030	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYG86_RS17035	COG1302	Protein conserved in bacteria
HYG86_RS17040	COG1461	Dihydroxyacetone kinase
HYG86_RS17050	COG1760	l-serine dehydratase
HYG86_RS17055	COG1760	l-serine dehydratase
HYG86_RS17060	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HYG86_RS17075	COG0742	ribosomal rna small subunit methyltransferase
HYG86_RS17080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HYG86_RS17085	COG3314	Sporulation integral membrane protein YlbJ
HYG86_RS17090	COG1752	Esterase of the alpha-beta hydrolase superfamily
HYG86_RS17095	COG3480	Lon protease (S16) C-terminal proteolytic domain
HYG86_RS17100	COG1323	Belongs to the UPF0348 family
HYG86_RS17105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HYG86_RS17115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HYG86_RS17125	COG0416	fatty acid biosynthetic process
HYG86_RS17130	COG1307	EDD domain protein, DegV family
HYG86_RS17135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYG86_RS17140	COG0571	ribonuclease III activity
HYG86_RS17145	COG1196	nuclear chromosome segregation
HYG86_RS17150	COG0552	protein localization to endoplasmic reticulum
HYG86_RS17155	COG1595	DNA-templated transcription, initiation
HYG86_RS17160	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HYG86_RS17165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HYG86_RS17185	COG0336	Belongs to the RNA methyltransferase TrmD family
HYG86_RS17190	COG0335	large ribosomal subunit rRNA binding
HYG86_RS17200	COG0681	Belongs to the peptidase S26 family
HYG86_RS17205	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HYG86_RS17220	COG0792	nuclease activity
HYG86_RS17235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYG86_RS17240	COG0606	chelatase, subunit chli
HYG86_RS17245	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HYG86_RS17255	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYG86_RS17260	COG1363	Peptidase, m42
HYG86_RS17265	COG1363	Peptidase, m42
HYG86_RS17280	COG1803	Methylglyoxal synthase
HYG86_RS17285	COG0018	arginyl-trna synthetase
HYG86_RS17290	COG1509	lysine 2,3-aminomutase activity
HYG86_RS17295	COG0758	DNA mediated transformation
HYG86_RS17300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYG86_RS17305	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HYG86_RS17310	COG4974	Belongs to the 'phage' integrase family
HYG86_RS17320	COG1815	bacterial-type flagellum-dependent cell motility
HYG86_RS17325	COG1558	bacterial-type flagellum-dependent cell motility
HYG86_RS17330	COG1677	Flagellar hook-basal body complex protein FliE
HYG86_RS17340	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYG86_RS17350	COG1157	protein secretion by the type III secretion system
HYG86_RS17370	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HYG86_RS17380	COG4786	Flagellar basal body rod
HYG86_RS17385	COG1582	Flagellar protein (FlbD)
HYG86_RS17395	COG1360	Flagellar Motor Protein
HYG86_RS17405	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYG86_RS17410	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYG86_RS17410	COG1776	CheC inhibitor of MCP methylation
HYG86_RS17415	COG2201	protein-glutamate methylesterase activity
HYG86_RS17420	COG3190	flagellar
HYG86_RS17425	COG1338	Plays a role in the flagellum-specific transport system
HYG86_RS17430	COG1987	bacterial-type flagellum assembly
HYG86_RS17435	COG1684	flagellar biosynthetic protein fliR
HYG86_RS17440	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYG86_RS17445	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYG86_RS17450	COG1419	protein localization to endoplasmic reticulum
HYG86_RS17455	COG0455	bacterial-type flagellum organization
HYG86_RS17465	COG2198	Histidine kinase
HYG86_RS17465	COG0643	Histidine kinase
HYG86_RS17470	COG0835	chemotaxis
HYG86_RS17475	COG1776	CheC inhibitor of MCP methylation
HYG86_RS17480	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HYG86_RS17485	COG1191	sigma factor activity
HYG86_RS17515	COG0052	Belongs to the universal ribosomal protein uS2 family
HYG86_RS17520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYG86_RS17525	COG0528	UMP kinase activity
HYG86_RS17530	COG0233	cytoplasmic translational termination
HYG86_RS17545	COG0575	Belongs to the CDS family
HYG86_RS17555	COG0750	zinc metalloprotease
HYG86_RS17560	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HYG86_RS17565	COG0442	prolyl-tRNA aminoacylation
HYG86_RS17570	COG0463	Glycosyl transferase, family 2
HYG86_RS17575	COG1285	pathogenesis
HYG86_RS17585	COG0779	Required for maturation of 30S ribosomal subunits
HYG86_RS17590	COG0195	Participates in both transcription termination and antitermination
HYG86_RS17595	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HYG86_RS17600	COG1358	cellular component organization or biogenesis
HYG86_RS17605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HYG86_RS17610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HYG86_RS17620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HYG86_RS17625	COG0196	riboflavin kinase activity
HYG86_RS17630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HYG86_RS17635	COG1185	polyribonucleotide nucleotidyltransferase activity
HYG86_RS17640	COG0726	polysaccharide deacetylase
HYG86_RS17650	COG1873	PFAM PRC-barrel domain
HYG86_RS17660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYG86_RS17665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HYG86_RS17670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HYG86_RS17675	COG0527	aspartate kinase activity
HYG86_RS17680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYG86_RS17700	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HYG86_RS17705	COG0740	serine-type endopeptidase activity
HYG86_RS17715	COG1968	undecaprenyl-diphosphatase activity
HYG86_RS17725	COG2188	Transcriptional regulator
HYG86_RS17730	COG1744	ABC transporter substrate-binding protein PnrA-like
HYG86_RS17735	COG3845	ABC transporter
HYG86_RS17740	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYG86_RS17745	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYG86_RS17750	COG0789	Transcriptional regulator
HYG86_RS17755	COG0174	glutamine synthetase
HYG86_RS17770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYG86_RS17775	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYG86_RS17785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYG86_RS17790	COG1058	Belongs to the CinA family
HYG86_RS17790	COG1546	Belongs to the CinA family
HYG86_RS17800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HYG86_RS17815	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYG86_RS17830	COG1418	mRNA catabolic process
HYG86_RS17835	COG1692	metallophosphoesterase
HYG86_RS17840	COG2359	stage V sporulation protein S
HYG86_RS17850	COG0613	PHP domain protein
HYG86_RS17865	COG4869	propanediol catabolic process
HYG86_RS17880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYG86_RS17885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYG86_RS17895	COG2136	Putative SAM-dependent methyltransferase
HYG86_RS17895	COG2521	methyltransferase
HYG86_RS17900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HYG86_RS17905	COG1923	regulation of RNA biosynthetic process
HYG86_RS17910	COG0464	growth
HYG86_RS17915	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HYG86_RS17930	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HYG86_RS17940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYG86_RS17950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HYG86_RS18010	COG1053	succinate dehydrogenase
HYG86_RS18015	COG2257	FlhB HrpN YscU SpaS Family
HYG86_RS18030	COG0840	transmembrane signaling receptor activity
HYG86_RS18045	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HYG86_RS18055	COG0728	peptidoglycan biosynthetic process
HYG86_RS18060	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HYG86_RS18065	COG0708	Exodeoxyribonuclease III
HYG86_RS18075	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HYG86_RS18080	COG0489	protein tyrosine kinase activity
HYG86_RS18090	COG0326	Molecular chaperone. Has ATPase activity
HYG86_RS18095	COG0322	excinuclease ABC activity
HYG86_RS18115	COG2385	sporulation resulting in formation of a cellular spore
HYG86_RS18140	COG0537	adenosine 5'-monophosphoramidase activity
HYG86_RS18145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HYG86_RS18155	COG0653	protein targeting
HYG86_RS18170	COG1388	LysM domain
HYG86_RS18170	COG1705	Flagellar rod assembly protein muramidase FlgJ
HYG86_RS18210	COG0823	Involved in the tonB-independent uptake of proteins
HYG86_RS18210	COG1506	peptidase
HYG86_RS18210	COG4946	Tricorn protease homolog
HYG86_RS18240	COG0537	adenosine 5'-monophosphoramidase activity