locus-tag	class	description
BPOF4_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BPOF4_RS00010	COG0592	DNA-directed DNA polymerase activity
BPOF4_RS00015	COG2501	S4 domain
BPOF4_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BPOF4_RS00030	COG0187	DNA topoisomerase II activity
BPOF4_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BPOF4_RS00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BPOF4_RS00065	COG0516	GMP reductase activity
BPOF4_RS00065	COG0517	IMP dehydrogenase activity
BPOF4_RS00075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BPOF4_RS00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BPOF4_RS00085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BPOF4_RS00090	COG4608	Belongs to the ABC transporter superfamily
BPOF4_RS00095	COG0444	Belongs to the ABC transporter superfamily
BPOF4_RS00100	COG0601	transmembrane transport
BPOF4_RS00105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BPOF4_RS00110	COG0747	negative chemotaxis
BPOF4_RS00120	COG0590	tRNA wobble adenosine to inosine editing
BPOF4_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BPOF4_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BPOF4_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BPOF4_RS00170	COG1982	Orn Lys Arg decarboxylase major
BPOF4_RS00175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BPOF4_RS00180	COG3870	Protein conserved in bacteria
BPOF4_RS00185	COG0470	DNA polymerase III
BPOF4_RS00190	COG1774	PSP1 C-terminal conserved region
BPOF4_RS00195	COG4467	Involved in initiation control of chromosome replication
BPOF4_RS00200	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BPOF4_RS00205	COG2827	Endonuclease containing a URI domain
BPOF4_RS00210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BPOF4_RS00215	COG2002	toxin-antitoxin pair type II binding
BPOF4_RS00230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BPOF4_RS00230	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BPOF4_RS00235	COG0084	hydrolase, TatD family'
BPOF4_RS00240	COG3583	domain protein
BPOF4_RS00240	COG3584	3D domain protein
BPOF4_RS00250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BPOF4_RS00260	COG4466	Protein conserved in bacteria
BPOF4_RS00270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BPOF4_RS00275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BPOF4_RS00280	COG0251	oxidation-reduction process
BPOF4_RS00285	COG2088	sporulation resulting in formation of a cellular spore
BPOF4_RS00290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BPOF4_RS00295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BPOF4_RS00300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BPOF4_RS00305	COG0193	aminoacyl-tRNA hydrolase activity
BPOF4_RS00315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BPOF4_RS00320	COG2002	toxin-antitoxin pair type II binding
BPOF4_RS00325	COG2244	polysaccharide biosynthetic process
BPOF4_RS00330	COG3956	TIGRFAM MazG family protein
BPOF4_RS00335	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BPOF4_RS00355	COG1098	S1 RNA binding domain
BPOF4_RS00365	COG2208	phosphoserine phosphatase activity
BPOF4_RS00370	COG2304	oxidoreductase activity
BPOF4_RS00375	COG0515	serine threonine protein kinase
BPOF4_RS00380	COG2966	Psort location CytoplasmicMembrane, score
BPOF4_RS00390	COG0037	tRNA processing
BPOF4_RS00395	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BPOF4_RS00400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BPOF4_RS00405	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BPOF4_RS00410	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BPOF4_RS00415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BPOF4_RS00420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BPOF4_RS00425	COG0512	Glutamine amidotransferase of anthranilate synthase
BPOF4_RS00430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BPOF4_RS00435	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BPOF4_RS00440	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BPOF4_RS00445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BPOF4_RS00450	COG1396	sequence-specific DNA binding
BPOF4_RS00455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BPOF4_RS00460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BPOF4_RS00485	COG3880	PFAM UvrB UvrC protein
BPOF4_RS00490	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BPOF4_RS00495	COG0542	response to heat
BPOF4_RS00500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BPOF4_RS00505	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BPOF4_RS00510	COG4956	integral membrane protein (PIN domain superfamily)
BPOF4_RS00515	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BPOF4_RS00525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BPOF4_RS00530	COG1045	serine acetyltransferase
BPOF4_RS00535	COG0215	cysteine-tRNA ligase activity
BPOF4_RS00545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BPOF4_RS00550	COG3688	RNA-binding protein containing a PIN domain
BPOF4_RS00560	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BPOF4_RS00565	COG0250	Participates in transcription elongation, termination and antitermination
BPOF4_RS00570	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BPOF4_RS00575	COG0081	regulation of translation
BPOF4_RS00580	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BPOF4_RS00585	COG0222	ribosome binding
BPOF4_RS00590	COG2813	Specifically methylates the guanine in position
BPOF4_RS00595	COG0085	RNA polymerase activity
BPOF4_RS00600	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BPOF4_RS00605	COG1358	cellular component organization or biogenesis
BPOF4_RS00610	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BPOF4_RS00615	COG0049	tRNA binding
BPOF4_RS00620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BPOF4_RS00625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BPOF4_RS00630	COG0051	transcription antitermination factor activity, RNA binding
BPOF4_RS00635	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BPOF4_RS00640	COG0088	Forms part of the polypeptide exit tunnel
BPOF4_RS00645	COG0089	rRNA binding
BPOF4_RS00650	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BPOF4_RS00655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BPOF4_RS00660	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BPOF4_RS00665	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BPOF4_RS00670	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BPOF4_RS00675	COG0255	Belongs to the universal ribosomal protein uL29 family
BPOF4_RS00680	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BPOF4_RS00685	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BPOF4_RS00690	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BPOF4_RS00695	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BPOF4_RS00700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BPOF4_RS00705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BPOF4_RS00710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BPOF4_RS00715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BPOF4_RS00720	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BPOF4_RS00725	COG1841	ribosomal large subunit assembly
BPOF4_RS00730	COG0200	Binds to the 23S rRNA
BPOF4_RS00735	COG0201	protein transport
BPOF4_RS00740	COG0563	adenylate kinase activity
BPOF4_RS00745	COG0024	Methionine aminopeptidase
BPOF4_RS00755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BPOF4_RS00760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BPOF4_RS00765	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BPOF4_RS00770	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BPOF4_RS00775	COG0202	RNA polymerase activity
BPOF4_RS00780	COG0203	ribosomal protein L17
BPOF4_RS00785	COG1122	ATPase activity
BPOF4_RS00790	COG1122	ATPase activity
BPOF4_RS00795	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BPOF4_RS00800	COG0101	tRNA pseudouridine synthase activity
BPOF4_RS00805	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BPOF4_RS00810	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BPOF4_RS00845	COG0860	N-Acetylmuramoyl-L-alanine amidase
BPOF4_RS00850	COG0489	protein tyrosine kinase activity
BPOF4_RS00860	COG2194	sulfuric ester hydrolase activity
BPOF4_RS00865	COG0726	polysaccharide deacetylase
BPOF4_RS00945	COG1595	DNA-templated transcription, initiation
BPOF4_RS00950	COG5662	AntiSigma factor
BPOF4_RS00955	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BPOF4_RS00960	COG4856	YbbR-like protein
BPOF4_RS00965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BPOF4_RS00970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BPOF4_RS00975	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BPOF4_RS00980	COG2404	hydrolase activity, acting on ester bonds
BPOF4_RS00985	COG1376	ErfK ybiS ycfS ynhG family protein
BPOF4_RS00995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BPOF4_RS01015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BPOF4_RS01020	COG1528	Iron-storage protein
BPOF4_RS01025	COG2233	PERMEase
BPOF4_RS01040	COG2329	Antibiotic biosynthesis monooxygenase
BPOF4_RS01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BPOF4_RS01050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BPOF4_RS01080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BPOF4_RS01090	COG1082	Xylose isomerase domain protein TIM barrel
BPOF4_RS01115	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BPOF4_RS01120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BPOF4_RS01125	COG0765	amino acid transport
BPOF4_RS01130	COG1126	abc transporter atp-binding protein
BPOF4_RS01135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BPOF4_RS01140	COG2011	ABC-type metal ion transport system permease component
BPOF4_RS01145	COG1464	Belongs to the NlpA lipoprotein family
BPOF4_RS01150	COG0747	negative chemotaxis
BPOF4_RS01160	COG0493	'glutamate synthase
BPOF4_RS01165	COG0167	dihydroorotate dehydrogenase activity
BPOF4_RS01165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BPOF4_RS01185	COG2508	Transcriptional regulator
BPOF4_RS01190	COG1012	belongs to the aldehyde dehydrogenase family
BPOF4_RS01195	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BPOF4_RS01210	COG1404	Belongs to the peptidase S8 family
BPOF4_RS01230	COG1733	regulation of RNA biosynthetic process
BPOF4_RS01235	COG0655	NAD(P)H dehydrogenase (quinone) activity
BPOF4_RS01240	COG0589	response to stress
BPOF4_RS01250	COG2239	Acts as a magnesium transporter
BPOF4_RS01255	COG3842	ATPase activity
BPOF4_RS01260	COG2182	Extracellular solute-binding protein
BPOF4_RS01265	COG1178	ABC-type Fe3 transport system permease component
BPOF4_RS01280	COG0803	Belongs to the bacterial solute-binding protein 9 family
BPOF4_RS01285	COG0705	Rhomboid family
BPOF4_RS01290	COG0736	holo-[acyl-carrier-protein] synthase activity
BPOF4_RS01295	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BPOF4_RS01300	COG0864	Transcriptional regulator
BPOF4_RS01305	COG2337	Toxic component of a toxin-antitoxin (TA) module
BPOF4_RS01310	COG1366	Belongs to the anti-sigma-factor antagonist family
BPOF4_RS01315	COG1366	Belongs to the anti-sigma-factor antagonist family
BPOF4_RS01320	COG2172	sigma factor antagonist activity
BPOF4_RS01325	COG2208	phosphoserine phosphatase activity
BPOF4_RS01330	COG1366	Belongs to the anti-sigma-factor antagonist family
BPOF4_RS01335	COG2172	sigma factor antagonist activity
BPOF4_RS01340	COG1191	sigma factor activity
BPOF4_RS01350	COG2183	response to ionizing radiation
BPOF4_RS01355	COG3091	SprT-like family
BPOF4_RS01445	COG0626	cystathionine gamma-synthase activity
BPOF4_RS01460	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BPOF4_RS01465	COG0802	atpase or kinase
BPOF4_RS01470	COG1214	PFAM Peptidase M22, glycoprotease
BPOF4_RS01475	COG0456	acetyltransferase
BPOF4_RS01480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BPOF4_RS01495	COG0488	(ABC) transporter
BPOF4_RS01500	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BPOF4_RS01505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BPOF4_RS01510	COG0805	protein transport
BPOF4_RS01515	COG2814	Major facilitator Superfamily
BPOF4_RS01520	COG1271	oxidase subunit
BPOF4_RS01525	COG1294	oxidase, subunit
BPOF4_RS01535	COG3835	regulator
BPOF4_RS01540	COG2610	gluconate transmembrane transporter activity
BPOF4_RS01545	COG1929	Belongs to the glycerate kinase type-1 family
BPOF4_RS01555	COG1266	CAAX protease self-immunity
BPOF4_RS01560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BPOF4_RS01565	COG0459	protein refolding
BPOF4_RS01570	COG0446	pyridine nucleotide-disulphide oxidoreductase
BPOF4_RS01575	COG0583	DNA-binding transcription factor activity
BPOF4_RS01580	COG0730	response to heat
BPOF4_RS01585	COG0804	urea catabolic process
BPOF4_RS01595	COG0831	urea catabolic process
BPOF4_RS01600	COG2851	Citrate transporter
BPOF4_RS01605	COG4565	transcriptional regulatory protein
BPOF4_RS01610	COG3290	protein histidine kinase activity
BPOF4_RS01635	COG4842	Belongs to the WXG100 family
BPOF4_RS01640	COG5417	Belongs to the EsaB family
BPOF4_RS01645	COG4499	WXG100 protein secretion system (Wss), protein YukC
BPOF4_RS01650	COG1674	ftsk spoiiie
BPOF4_RS01655	COG1511	domain protein
BPOF4_RS01710	COG2897	thiosulfate sulfurtransferase activity
BPOF4_RS01715	COG1846	Transcriptional regulator
BPOF4_RS01720	COG0490	domain, Protein
BPOF4_RS01725	COG0475	glutathione-regulated potassium exporter activity
BPOF4_RS01730	COG2357	RelA SpoT domain protein
BPOF4_RS01735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BPOF4_RS01740	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BPOF4_RS01745	COG1957	nucleoside hydrolase
BPOF4_RS01750	COG1132	(ABC) transporter
BPOF4_RS01755	COG2226	methyltransferase
BPOF4_RS01775	COG0714	Associated with various cellular activities
BPOF4_RS01780	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BPOF4_RS01785	COG1305	Transglutaminase-like
BPOF4_RS01790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BPOF4_RS01790	COG0519	Catalyzes the synthesis of GMP from XMP
BPOF4_RS01795	COG2252	PERMEase
BPOF4_RS01830	COG2258	MOSC domain
BPOF4_RS01835	COG3424	synthase
BPOF4_RS01840	COG1755	Isoprenylcysteine carboxyl methyltransferase
BPOF4_RS01845	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BPOF4_RS01855	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BPOF4_RS01860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BPOF4_RS01865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BPOF4_RS01870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BPOF4_RS01875	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BPOF4_RS01880	COG0047	phosphoribosylformylglycinamidine synthase activity
BPOF4_RS01885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BPOF4_RS01890	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BPOF4_RS01895	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BPOF4_RS01900	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BPOF4_RS01905	COG0138	bifunctional purine biosynthesis protein purh
BPOF4_RS01910	COG0151	Belongs to the GarS family
BPOF4_RS01920	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BPOF4_RS01925	COG1470	cell adhesion involved in biofilm formation
BPOF4_RS01930	COG4496	protein, YerC YecD
BPOF4_RS01935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BPOF4_RS01945	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BPOF4_RS01950	COG3835	regulator
BPOF4_RS01955	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BPOF4_RS01970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BPOF4_RS01975	COG0686	Belongs to the AlaDH PNT family
BPOF4_RS01980	COG2508	Transcriptional regulator
BPOF4_RS01980	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BPOF4_RS01985	COG1115	amino acid carrier protein
BPOF4_RS02005	COG0393	Putative heavy-metal-binding
BPOF4_RS02010	COG0688	phosphatidylethanolamine metabolic process
BPOF4_RS02020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BPOF4_RS02025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BPOF4_RS02035	COG0385	Bile acid
BPOF4_RS02040	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BPOF4_RS02045	COG0210	DNA helicase
BPOF4_RS02050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BPOF4_RS02055	COG4851	CamS sex pheromone cAM373 precursor
BPOF4_RS02060	COG1744	ABC transporter substrate-binding protein PnrA-like
BPOF4_RS02065	COG3845	ABC transporter
BPOF4_RS02070	COG4603	Belongs to the binding-protein-dependent transport system permease family
BPOF4_RS02075	COG1079	Belongs to the binding-protein-dependent transport system permease family
BPOF4_RS02080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BPOF4_RS02085	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BPOF4_RS02090	COG0154	amidase activity
BPOF4_RS02095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BPOF4_RS02100	COG1597	lipid kinase activity
BPOF4_RS02110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BPOF4_RS02130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BPOF4_RS02160	COG0577	efflux transmembrane transporter activity
BPOF4_RS02165	COG1136	(ABC) transporter
BPOF4_RS02170	COG0642	Histidine kinase
BPOF4_RS02175	COG0745	RESPONSE REGULATOR receiver
BPOF4_RS02205	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BPOF4_RS02215	COG3239	Fatty acid desaturase
BPOF4_RS02220	COG4585	Histidine kinase
BPOF4_RS02225	COG2197	response regulator
BPOF4_RS02240	COG3119	arylsulfatase activity
BPOF4_RS02255	COG0745	RESPONSE REGULATOR receiver
BPOF4_RS02305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BPOF4_RS02315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BPOF4_RS02340	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BPOF4_RS02345	COG1984	allophanate hydrolase subunit 2
BPOF4_RS02350	COG1414	Transcriptional regulator
BPOF4_RS02355	COG1914	H( )-stimulated, divalent metal cation uptake system
BPOF4_RS02360	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BPOF4_RS02365	COG1214	PFAM Peptidase M22, glycoprotease
BPOF4_RS02365	COG0456	acetyltransferase
BPOF4_RS02390	COG2066	Belongs to the glutaminase family
BPOF4_RS02405	COG3314	Sporulation integral membrane protein YlbJ
BPOF4_RS02410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BPOF4_RS02415	COG0840	transmembrane signaling receptor activity
BPOF4_RS02435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BPOF4_RS02440	COG0733	neurotransmitter:sodium symporter activity
BPOF4_RS02450	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BPOF4_RS02460	COG1309	transcriptional regulator
BPOF4_RS02470	COG1132	(ABC) transporter
BPOF4_RS02475	COG1132	(ABC) transporter
BPOF4_RS02490	COG1012	belongs to the aldehyde dehydrogenase family
BPOF4_RS02500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BPOF4_RS02510	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BPOF4_RS02520	COG1115	amino acid carrier protein
BPOF4_RS02525	COG2244	polysaccharide biosynthetic process
BPOF4_RS02530	COG1263	PTS System
BPOF4_RS02530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BPOF4_RS02535	COG0366	Alpha amylase catalytic
BPOF4_RS02540	COG2188	Transcriptional regulator
BPOF4_RS02545	COG0386	Belongs to the glutathione peroxidase family
BPOF4_RS02550	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BPOF4_RS02555	COG0488	(ABC) transporter
BPOF4_RS02565	COG1349	DNA-binding transcription factor activity
BPOF4_RS02570	COG1105	Belongs to the carbohydrate kinase PfkB family
BPOF4_RS02575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BPOF4_RS02575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BPOF4_RS02575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BPOF4_RS02580	COG0154	amidase activity
BPOF4_RS02585	COG3859	Proton-coupled thiamine transporter YuaJ
BPOF4_RS02590	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BPOF4_RS02595	COG1404	Belongs to the peptidase S8 family
BPOF4_RS02610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BPOF4_RS02625	COG1077	Cell shape determining protein MreB Mrl
BPOF4_RS02630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BPOF4_RS02630	COG1263	PTS System
BPOF4_RS02630	COG2190	(PTS) system
BPOF4_RS02635	COG3711	transcriptional antiterminator
BPOF4_RS02640	COG3011	Protein conserved in bacteria
BPOF4_RS02645	COG0733	neurotransmitter:sodium symporter activity
BPOF4_RS02660	COG1104	cysteine desulfurase activity
BPOF4_RS02665	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BPOF4_RS02670	COG0157	Belongs to the NadC ModD family
BPOF4_RS02675	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BPOF4_RS02680	COG0534	Mate efflux family protein
BPOF4_RS02690	COG0328	RNA-DNA hybrid ribonuclease activity
BPOF4_RS02690	COG3341	Caulimovirus viroplasmin
BPOF4_RS02695	COG1012	belongs to the aldehyde dehydrogenase family
BPOF4_RS02705	COG0753	catalase activity
BPOF4_RS02725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BPOF4_RS02730	COG0405	Gamma-glutamyltransferase
BPOF4_RS02735	COG1522	sequence-specific DNA binding
BPOF4_RS02740	COG2059	Chromate
BPOF4_RS02745	COG2059	Chromate
BPOF4_RS02755	COG0840	transmembrane signaling receptor activity
BPOF4_RS02760	COG1294	oxidase, subunit
BPOF4_RS02765	COG1271	oxidase subunit
BPOF4_RS02775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BPOF4_RS02785	COG0477	Major facilitator Superfamily
BPOF4_RS02795	COG0534	Mate efflux family protein
BPOF4_RS02800	COG2364	Membrane
BPOF4_RS02810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BPOF4_RS02820	COG0535	radical SAM domain protein
BPOF4_RS02835	COG1278	Cold shock
BPOF4_RS02855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BPOF4_RS02870	COG4989	oxidoreductase activity
BPOF4_RS02875	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS02880	COG4187	Peptidase family M20/M25/M40
BPOF4_RS02890	COG1126	abc transporter atp-binding protein
BPOF4_RS02895	COG0765	amino acid transport
BPOF4_RS02900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BPOF4_RS02910	COG1917	Cupin 2, conserved barrel domain protein
BPOF4_RS02915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BPOF4_RS02920	COG0456	acetyltransferase
BPOF4_RS02930	COG1090	epimerase
BPOF4_RS02935	COG2137	regulation of response to DNA damage stimulus
BPOF4_RS02950	COG1988	membrane-bound metal-dependent
BPOF4_RS02960	COG1194	a g-specific adenine glycosylase
BPOF4_RS02965	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS02975	COG0604	alcohol dehydrogenase
BPOF4_RS02980	COG0436	Aminotransferase
BPOF4_RS02990	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS03000	COG3557	Belongs to the UPF0374 family
BPOF4_RS03005	COG1132	(ABC) transporter
BPOF4_RS03010	COG4129	membrane
BPOF4_RS03015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BPOF4_RS03025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BPOF4_RS03030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BPOF4_RS03035	COG3870	Protein conserved in bacteria
BPOF4_RS03040	COG0735	belongs to the Fur family
BPOF4_RS03150	COG0129	dihydroxy-acid dehydratase activity
BPOF4_RS03165	COG2149	membrane
BPOF4_RS03185	COG5002	protein histidine kinase activity
BPOF4_RS03190	COG0737	Belongs to the 5'-nucleotidase family
BPOF4_RS03200	COG1012	belongs to the aldehyde dehydrogenase family
BPOF4_RS03205	COG0783	Belongs to the Dps family
BPOF4_RS03210	COG3382	B3 4 domain protein
BPOF4_RS03215	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BPOF4_RS03220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BPOF4_RS03230	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BPOF4_RS03245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BPOF4_RS03250	COG2766	serine protein kinase
BPOF4_RS03255	COG2718	Belongs to the UPF0229 family
BPOF4_RS03275	COG1120	ATPase activity
BPOF4_RS03290	COG2311	Membrane
BPOF4_RS03300	COG0436	Aminotransferase
BPOF4_RS03305	COG3546	catalase activity
BPOF4_RS03310	COG0473	3-isopropylmalate dehydrogenase activity
BPOF4_RS03315	COG0179	Fumarylacetoacetate (FAA) hydrolase
BPOF4_RS03320	COG2226	methyltransferase
BPOF4_RS03325	COG1115	amino acid carrier protein
BPOF4_RS03330	COG2610	gluconate transmembrane transporter activity
BPOF4_RS03335	COG0584	glycerophosphoryl diester phosphodiesterase
BPOF4_RS03355	COG0058	SHG alpha-glucan phosphorylase activity
BPOF4_RS03360	COG0297	glycogen (starch) synthase activity
BPOF4_RS03365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BPOF4_RS03370	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BPOF4_RS03385	COG3153	acetyltransferase
BPOF4_RS03385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BPOF4_RS03395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BPOF4_RS03400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BPOF4_RS03405	COG1619	proteins homologs of microcin C7 resistance protein MccF
BPOF4_RS03410	COG2719	SpoVR family
BPOF4_RS03420	COG1132	(ABC) transporter
BPOF4_RS03425	COG1132	(ABC) transporter
BPOF4_RS03430	COG0745	RESPONSE REGULATOR receiver
BPOF4_RS03435	COG5002	protein histidine kinase activity
BPOF4_RS03435	COG3850	Histidine kinase
BPOF4_RS03455	COG5001	Diguanylate cyclase
BPOF4_RS03460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BPOF4_RS03465	COG0733	neurotransmitter:sodium symporter activity
BPOF4_RS03470	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BPOF4_RS03475	COG1960	acyl-CoA dehydrogenase activity
BPOF4_RS03480	COG0318	PFAM AMP-dependent synthetase and ligase
BPOF4_RS03485	COG0439	Biotin carboxylase
BPOF4_RS03490	COG0511	ligase activity, forming carbon-carbon bonds
BPOF4_RS03495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BPOF4_RS03500	COG1024	Enoyl-CoA hydratase
BPOF4_RS03505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BPOF4_RS03510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BPOF4_RS03520	COG3842	ATPase activity
BPOF4_RS03525	COG2508	Transcriptional regulator
BPOF4_RS03545	COG4399	Belongs to the UPF0754 family
BPOF4_RS03550	COG3679	Belongs to the UPF0342 family
BPOF4_RS03560	COG0561	phosphatase activity
BPOF4_RS03580	COG1121	(ABC) transporter
BPOF4_RS03585	COG4152	abc transporter atp-binding protein
BPOF4_RS03590	COG1668	transmembrane transport
BPOF4_RS03600	COG0706	membrane insertase activity
BPOF4_RS03610	COG0745	RESPONSE REGULATOR receiver
BPOF4_RS03615	COG2770	Histidine kinase
BPOF4_RS03615	COG2205	protein histidine kinase activity
BPOF4_RS03620	COG2814	Major facilitator Superfamily
BPOF4_RS03625	COG3481	metal-dependent phosphohydrolase, HD sub domain
BPOF4_RS03635	COG2323	membrane
BPOF4_RS03640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BPOF4_RS03660	COG1846	Transcriptional regulator
BPOF4_RS03680	COG0537	adenosine 5'-monophosphoramidase activity
BPOF4_RS03685	COG0318	PFAM AMP-dependent synthetase and ligase
BPOF4_RS03705	COG1131	(ABC) transporter
BPOF4_RS03710	COG4473	ABC transporter
BPOF4_RS03720	COG0785	Cytochrome C biogenesis protein
BPOF4_RS03730	COG1842	Phage shock protein A
BPOF4_RS03740	COG4758	membrane
BPOF4_RS03745	COG4585	Histidine kinase
BPOF4_RS03750	COG2197	response regulator
BPOF4_RS03755	COG2329	Antibiotic biosynthesis monooxygenase
BPOF4_RS03760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BPOF4_RS03765	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BPOF4_RS03770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BPOF4_RS03775	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BPOF4_RS03800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BPOF4_RS03805	COG4492	Belongs to the UPF0735 family
BPOF4_RS03810	COG0077	Prephenate dehydratase
BPOF4_RS03815	COG1827	regulation of RNA biosynthetic process
BPOF4_RS03835	COG0632	four-way junction helicase activity
BPOF4_RS03840	COG2255	four-way junction helicase activity
BPOF4_RS03850	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BPOF4_RS03855	COG0343	queuine tRNA-ribosyltransferase activity
BPOF4_RS03860	COG1862	Preprotein translocase
BPOF4_RS03870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BPOF4_RS03875	COG2323	membrane
BPOF4_RS03890	COG2244	polysaccharide biosynthetic process
BPOF4_RS03910	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BPOF4_RS03915	COG5416	Lipopolysaccharide assembly protein A domain
BPOF4_RS03920	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BPOF4_RS03920	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BPOF4_RS03925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BPOF4_RS03930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BPOF4_RS03945	COG0124	histidyl-tRNA synthetase
BPOF4_RS03950	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BPOF4_RS03955	COG0460	homoserine dehydrogenase
BPOF4_RS03965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BPOF4_RS03975	COG5002	protein histidine kinase activity
BPOF4_RS03980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BPOF4_RS03985	COG2364	Membrane
BPOF4_RS03990	COG1959	2 iron, 2 sulfur cluster binding
BPOF4_RS03995	COG1104	cysteine desulfurase activity
BPOF4_RS04000	COG0482	sulfurtransferase activity
BPOF4_RS04010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BPOF4_RS04030	COG0628	permease
BPOF4_RS04035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BPOF4_RS04040	COG4472	Bacterial protein of unknown function (DUF965)
BPOF4_RS04045	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BPOF4_RS04050	COG3906	Belongs to the UPF0473 family
BPOF4_RS04055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BPOF4_RS04060	COG4122	O-methyltransferase activity
BPOF4_RS04065	COG0826	peptidase U32
BPOF4_RS04070	COG0826	peptidase U32
BPOF4_RS04075	COG0572	uridine kinase
BPOF4_RS04080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BPOF4_RS04085	COG1960	acyl-CoA dehydrogenase activity
BPOF4_RS04100	COG2217	Heavy metal translocating P-type atpase
BPOF4_RS04135	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BPOF4_RS04150	COG3052	prosthetic group binding
BPOF4_RS04175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BPOF4_RS04205	COG0542	response to heat
BPOF4_RS04210	COG0791	NLP P60 protein
BPOF4_RS04220	COG0840	transmembrane signaling receptor activity
BPOF4_RS04235	COG4948	Mandelate Racemase Muconate Lactonizing
BPOF4_RS04280	COG1131	(ABC) transporter
BPOF4_RS04285	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BPOF4_RS04295	COG0277	FAD linked oxidase domain protein
BPOF4_RS04300	COG2378	regulation of single-species biofilm formation
BPOF4_RS04330	COG1131	(ABC) transporter
BPOF4_RS04335	COG3559	Exporter of polyketide antibiotics
BPOF4_RS04340	COG1595	DNA-templated transcription, initiation
BPOF4_RS04370	COG0814	amino acid
BPOF4_RS04380	COG0697	spore germination
BPOF4_RS04395	COG1132	(ABC) transporter
BPOF4_RS04400	COG4946	Tricorn protease homolog
BPOF4_RS04400	COG1506	peptidase
BPOF4_RS04400	COG0823	Involved in the tonB-independent uptake of proteins
BPOF4_RS04425	COG1288	antiporter activity
BPOF4_RS04450	COG0582	viral genome integration into host DNA
BPOF4_RS04455	COG3263	regulation of cellular component size
BPOF4_RS04475	COG0745	RESPONSE REGULATOR receiver
BPOF4_RS04505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BPOF4_RS04505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BPOF4_RS04515	COG0501	Belongs to the peptidase M48B family
BPOF4_RS04520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BPOF4_RS04520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BPOF4_RS04525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BPOF4_RS04540	COG0561	phosphatase activity
BPOF4_RS04555	COG1454	alcohol dehydrogenase
BPOF4_RS04565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BPOF4_RS04570	COG0583	DNA-binding transcription factor activity
BPOF4_RS04595	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS04620	COG0789	Transcriptional regulator
BPOF4_RS04635	COG4565	transcriptional regulatory protein
BPOF4_RS04640	COG3290	protein histidine kinase activity
BPOF4_RS04660	COG0039	L-malate dehydrogenase activity
BPOF4_RS04670	COG0583	DNA-binding transcription factor activity
BPOF4_RS04675	COG0028	Belongs to the TPP enzyme family
BPOF4_RS04680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BPOF4_RS04685	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BPOF4_RS04690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BPOF4_RS04700	COG1012	belongs to the aldehyde dehydrogenase family
BPOF4_RS04715	COG2807	transmembrane transport
BPOF4_RS04720	COG1414	Transcriptional regulator
BPOF4_RS04740	COG1414	Transcriptional regulator
BPOF4_RS04780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BPOF4_RS04795	COG1620	l-lactate permease
BPOF4_RS04800	COG0247	lactate metabolic process
BPOF4_RS04805	COG1139	Iron-sulfur cluster binding protein
BPOF4_RS04810	COG1556	Lactate utilization protein
BPOF4_RS04815	COG2186	Transcriptional regulator
BPOF4_RS04820	COG3361	conserved protein (COG2071)
BPOF4_RS04830	COG2271	Major facilitator Superfamily
BPOF4_RS04875	COG2234	aminopeptidase activity
BPOF4_RS04935	COG2188	Transcriptional regulator
BPOF4_RS04940	COG1486	melibiose metabolic process
BPOF4_RS04945	COG2190	(PTS) system
BPOF4_RS04945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BPOF4_RS04945	COG1263	PTS System
BPOF4_RS04950	COG0697	spore germination
BPOF4_RS04965	COG3383	formate dehydrogenase (NAD+) activity
BPOF4_RS04985	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BPOF4_RS04995	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BPOF4_RS05010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BPOF4_RS05020	COG2814	Major facilitator Superfamily
BPOF4_RS05025	COG0494	nUDIX hydrolase
BPOF4_RS05030	COG1846	Transcriptional regulator
BPOF4_RS05035	COG0095	Lipoate-protein ligase
BPOF4_RS05050	COG0456	acetyltransferase
BPOF4_RS05060	COG1366	Belongs to the anti-sigma-factor antagonist family
BPOF4_RS05080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BPOF4_RS05095	COG5002	protein histidine kinase activity
BPOF4_RS05105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BPOF4_RS05110	COG0785	Cytochrome C biogenesis protein
BPOF4_RS05125	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
BPOF4_RS05130	COG1388	LysM domain
BPOF4_RS05140	COG2267	carboxylic ester hydrolase activity
BPOF4_RS05150	COG0840	transmembrane signaling receptor activity
BPOF4_RS05155	COG2205	protein histidine kinase activity
BPOF4_RS05165	COG0784	Response regulator, receiver
BPOF4_RS05165	COG2198	Histidine kinase
BPOF4_RS05165	COG5002	protein histidine kinase activity
BPOF4_RS05170	COG3279	Response regulator of the LytR AlgR family
BPOF4_RS05205	COG2205	protein histidine kinase activity
BPOF4_RS05205	COG0784	Response regulator, receiver
BPOF4_RS05205	COG5002	protein histidine kinase activity
BPOF4_RS05210	COG0671	phosphoesterase, PA-phosphatase related
BPOF4_RS05215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BPOF4_RS05220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BPOF4_RS05245	COG0656	L-ascorbic acid biosynthetic process
BPOF4_RS05250	COG1785	Belongs to the alkaline phosphatase family
BPOF4_RS05260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BPOF4_RS05265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BPOF4_RS05270	COG1116	anion transmembrane transporter activity
BPOF4_RS05275	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BPOF4_RS05280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BPOF4_RS05285	COG0776	regulation of translation
BPOF4_RS05290	COG1183	phosphatidylcholine synthase activity
BPOF4_RS05300	COG1320	monovalent cation:proton antiporter activity
BPOF4_RS05305	COG2212	antiporter activity
BPOF4_RS05310	COG1863	multisubunit Na H antiporter MnhE subunit
BPOF4_RS05315	COG0651	ATP synthesis coupled electron transport
BPOF4_RS05320	COG1006	Multisubunit Na H antiporter MnhC subunit
BPOF4_RS05325	COG2111	Na H antiporter
BPOF4_RS05330	COG2111	Na H antiporter
BPOF4_RS05330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BPOF4_RS05345	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BPOF4_RS05350	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BPOF4_RS05355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BPOF4_RS05360	COG1534	Rna-binding protein
BPOF4_RS05365	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BPOF4_RS05370	COG1713	HD superfamily hydrolase involved in NAD metabolism
BPOF4_RS05375	COG0799	negative regulation of ribosome biogenesis
BPOF4_RS05380	COG2996	Protein conserved in bacteria
BPOF4_RS05385	COG2226	methyltransferase
BPOF4_RS05390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BPOF4_RS05400	COG1555	photosystem II stabilization
BPOF4_RS05400	COG1596	polysaccharide export
BPOF4_RS05405	COG2131	deaminase
BPOF4_RS05410	COG2333	competence protein COMEC
BPOF4_RS05410	COG0658	competence protein
BPOF4_RS05420	COG1466	dna polymerase III delta subunit
BPOF4_RS05425	COG0268	Binds directly to 16S ribosomal RNA
BPOF4_RS05430	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BPOF4_RS05435	COG0860	N-Acetylmuramoyl-L-alanine amidase
BPOF4_RS05445	COG0481	GTPase activity
BPOF4_RS05450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BPOF4_RS05455	COG1420	regulation of RNA biosynthetic process
BPOF4_RS05460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BPOF4_RS05465	COG0443	Heat shock 70 kDa protein
BPOF4_RS05470	COG0484	heat shock protein binding
BPOF4_RS05475	COG2264	protein methyltransferase activity
BPOF4_RS05480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BPOF4_RS05485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BPOF4_RS05490	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BPOF4_RS05500	COG0697	spore germination
BPOF4_RS05510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BPOF4_RS05515	COG1937	Protein conserved in bacteria
BPOF4_RS05520	COG1309	transcriptional regulator
BPOF4_RS05525	COG0183	Belongs to the thiolase family
BPOF4_RS05535	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS05540	COG0318	PFAM AMP-dependent synthetase and ligase
BPOF4_RS05545	COG2610	gluconate transmembrane transporter activity
BPOF4_RS05550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BPOF4_RS05555	COG1285	pathogenesis
BPOF4_RS05560	COG1937	Protein conserved in bacteria
BPOF4_RS05565	COG0425	Belongs to the sulfur carrier protein TusA family
BPOF4_RS05565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BPOF4_RS05575	COG0425	Belongs to the sulfur carrier protein TusA family
BPOF4_RS05585	COG0288	reversible hydration of carbon dioxide
BPOF4_RS05590	COG2210	Belongs to the sulfur carrier protein TusA family
BPOF4_RS05595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BPOF4_RS05600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BPOF4_RS05610	COG1595	DNA-templated transcription, initiation
BPOF4_RS05620	COG2824	Alkylphosphonate utilization operon protein PhnA
BPOF4_RS05630	COG1283	sodium-dependent phosphate transmembrane transporter activity
BPOF4_RS05640	COG0318	PFAM AMP-dependent synthetase and ligase
BPOF4_RS05650	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS05665	COG1250	3-hydroxyacyl-CoA dehydrogenase
BPOF4_RS05670	COG1024	Enoyl-CoA hydratase
BPOF4_RS05680	COG2045	Belongs to the ComB family
BPOF4_RS05685	COG1960	acyl-CoA dehydrogenase activity
BPOF4_RS05695	COG1024	Enoyl-CoA hydratase
BPOF4_RS05730	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BPOF4_RS05735	COG1610	YqeY-like protein
BPOF4_RS05740	COG1030	water channel activity
BPOF4_RS05745	COG4864	UPF0365 protein
BPOF4_RS05765	COG1702	phosphate starvation-inducible protein PhoH
BPOF4_RS05770	COG1480	7TM receptor with intracellular HD hydrolase
BPOF4_RS05775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BPOF4_RS05780	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BPOF4_RS05790	COG0295	cytidine deaminase activity
BPOF4_RS05795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BPOF4_RS05800	COG1381	Involved in DNA repair and RecF pathway recombination
BPOF4_RS05805	COG0752	glycyl-tRNA synthetase alpha subunit
BPOF4_RS05810	COG0751	glycine-tRNA ligase activity
BPOF4_RS05815	COG0517	IMP dehydrogenase activity
BPOF4_RS05820	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BPOF4_RS05825	COG1671	Belongs to the UPF0178 family
BPOF4_RS05830	COG0358	DNA primase activity
BPOF4_RS05835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BPOF4_RS05845	COG2010	Cytochrome c
BPOF4_RS05850	COG2384	SAM-dependent methyltransferase
BPOF4_RS05855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BPOF4_RS05860	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BPOF4_RS05865	COG1329	Transcriptional regulator
BPOF4_RS05875	COG0513	Belongs to the DEAD box helicase family
BPOF4_RS05880	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BPOF4_RS05890	COG5002	protein histidine kinase activity
BPOF4_RS05895	COG1121	(ABC) transporter
BPOF4_RS05900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BPOF4_RS05910	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BPOF4_RS05920	COG1121	(ABC) transporter
BPOF4_RS05925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BPOF4_RS05930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BPOF4_RS05935	COG0735	belongs to the Fur family
BPOF4_RS05945	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BPOF4_RS05950	COG4709	membrane
BPOF4_RS05955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BPOF4_RS05960	COG1388	LysM domain
BPOF4_RS05965	COG2814	Major facilitator Superfamily
BPOF4_RS05970	COG4086	secreted protein
BPOF4_RS05985	COG0704	Plays a role in the regulation of phosphate uptake
BPOF4_RS06015	COG1968	undecaprenyl-diphosphatase activity
BPOF4_RS06020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BPOF4_RS06025	COG0477	Major facilitator Superfamily
BPOF4_RS06030	COG0768	penicillin binding
BPOF4_RS06055	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BPOF4_RS06065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BPOF4_RS06070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BPOF4_RS06080	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BPOF4_RS06090	COG1757	Na H antiporter
BPOF4_RS06105	COG0457	Tetratricopeptide repeat
BPOF4_RS06105	COG0705	Rhomboid family
BPOF4_RS06115	COG0697	spore germination
BPOF4_RS06135	COG1940	carbohydrate kinase activity
BPOF4_RS06140	COG1027	Aspartate ammonia-lyase
BPOF4_RS06150	COG0352	thiamine-phosphate diphosphorylase activity
BPOF4_RS06160	COG2022	thiamine diphosphate biosynthetic process
BPOF4_RS06165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BPOF4_RS06165	COG2022	thiamine diphosphate biosynthetic process
BPOF4_RS06170	COG0351	phosphomethylpyrimidine kinase
BPOF4_RS06175	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BPOF4_RS06180	COG0390	transport system, permease component
BPOF4_RS06195	COG2153	protein acetylation
BPOF4_RS06200	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BPOF4_RS06205	COG2382	esterase
BPOF4_RS06210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BPOF4_RS06220	COG0114	fumarate hydratase activity
BPOF4_RS06225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BPOF4_RS06230	COG1725	Transcriptional regulator
BPOF4_RS06235	COG1131	(ABC) transporter
BPOF4_RS06245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BPOF4_RS06260	COG2818	Glycosylase
BPOF4_RS06300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BPOF4_RS06315	COG5002	protein histidine kinase activity
BPOF4_RS06320	COG0745	RESPONSE REGULATOR receiver
BPOF4_RS06350	COG0730	response to heat
BPOF4_RS06365	COG1280	lysine exporter protein (LysE YggA)
BPOF4_RS06375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BPOF4_RS06380	COG0765	amino acid transport
BPOF4_RS06385	COG1126	abc transporter atp-binding protein
BPOF4_RS06390	COG4129	membrane
BPOF4_RS06395	COG1376	ErfK ybiS ycfS ynhG family protein
BPOF4_RS06400	COG0346	lactoylglutathione lyase activity
BPOF4_RS06405	COG2195	Cleaves the N-terminal amino acid of tripeptides
BPOF4_RS06425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BPOF4_RS06435	COG2257	FlhB HrpN YscU SpaS Family
BPOF4_RS06450	COG1728	Protein conserved in bacteria
BPOF4_RS06465	COG1902	pentaerythritol trinitrate reductase activity
BPOF4_RS06470	COG0517	IMP dehydrogenase activity
BPOF4_RS06485	COG0175	sulfate reduction
BPOF4_RS06490	COG2046	Belongs to the sulfate adenylyltransferase family
BPOF4_RS06495	COG0306	phosphate transporter
BPOF4_RS06500	COG0529	Catalyzes the synthesis of activated sulfate
BPOF4_RS06515	COG2861	carbohydrate metabolic process
BPOF4_RS06520	COG0789	Transcriptional regulator
BPOF4_RS06525	COG1587	Uroporphyrinogen-III synthase
BPOF4_RS06525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BPOF4_RS06540	COG1469	GTP cyclohydrolase I activity
BPOF4_RS06550	COG0527	aspartate kinase activity
BPOF4_RS06575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BPOF4_RS06580	COG0300	oxidoreductase activity
BPOF4_RS06590	COG0367	asparagine synthase
BPOF4_RS06595	COG1309	transcriptional regulator
BPOF4_RS06600	COG1511	domain protein
BPOF4_RS06630	COG0745	RESPONSE REGULATOR receiver
BPOF4_RS06635	COG5002	protein histidine kinase activity
BPOF4_RS06655	COG1562	ergosterol biosynthetic process
BPOF4_RS06680	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS06685	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS06695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BPOF4_RS06700	COG4166	transmembrane transport
BPOF4_RS06705	COG2190	(PTS) system
BPOF4_RS06710	COG3711	transcriptional antiterminator
BPOF4_RS06715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BPOF4_RS06730	COG1966	Carbon starvation protein
BPOF4_RS06740	COG0701	Predicted permease
BPOF4_RS06745	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BPOF4_RS06750	COG0523	cobalamin synthesis protein
BPOF4_RS06755	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BPOF4_RS06760	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BPOF4_RS06765	COG1850	ribulose-bisphosphate carboxylase activity
BPOF4_RS06770	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BPOF4_RS06775	COG0235	Class ii aldolase
BPOF4_RS06780	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BPOF4_RS06790	COG0702	epimerase
BPOF4_RS06800	COG1968	undecaprenyl-diphosphatase activity
BPOF4_RS06805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BPOF4_RS06815	COG0494	nUDIX hydrolase
BPOF4_RS06820	COG0626	cystathionine gamma-synthase activity
BPOF4_RS06825	COG1300	Membrane
BPOF4_RS06830	COG0735	belongs to the Fur family
BPOF4_RS06840	COG4974	Belongs to the 'phage' integrase family
BPOF4_RS06845	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BPOF4_RS06865	COG1764	response to oxidative stress
BPOF4_RS06875	COG1988	membrane-bound metal-dependent
BPOF4_RS06880	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BPOF4_RS06895	COG1301	dicarboxylic acid transport
BPOF4_RS06905	COG1686	Belongs to the peptidase S11 family
BPOF4_RS06915	COG2172	sigma factor antagonist activity
BPOF4_RS06940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BPOF4_RS06955	COG0697	spore germination
BPOF4_RS06965	COG0019	diaminopimelate decarboxylase activity
BPOF4_RS06970	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BPOF4_RS06975	COG0006	proline dipeptidase activity
BPOF4_RS06985	COG1131	(ABC) transporter
BPOF4_RS06990	COG1725	Transcriptional regulator
BPOF4_RS07010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BPOF4_RS07010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BPOF4_RS07015	COG0307	riboflavin synthase, alpha
BPOF4_RS07020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BPOF4_RS07020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BPOF4_RS07025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BPOF4_RS07030	COG0456	acetyltransferase
BPOF4_RS07035	COG1547	Domain of unknown function (DUF309)
BPOF4_RS07040	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BPOF4_RS07045	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BPOF4_RS07050	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BPOF4_RS07060	COG2323	membrane
BPOF4_RS07085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BPOF4_RS07100	COG2323	membrane
BPOF4_RS07105	COG2323	membrane
BPOF4_RS07110	COG1686	Belongs to the peptidase S11 family
BPOF4_RS07115	COG2715	membrane protein required for spore maturation
BPOF4_RS07120	COG0700	Nucleoside recognition
BPOF4_RS07125	COG1187	pseudouridine synthase activity
BPOF4_RS07130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BPOF4_RS07135	COG1333	cytochrome c biogenesis protein
BPOF4_RS07140	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BPOF4_RS07145	COG0745	RESPONSE REGULATOR receiver
BPOF4_RS07150	COG5002	protein histidine kinase activity
BPOF4_RS07160	COG0534	Mate efflux family protein
BPOF4_RS07165	COG5577	PFAM Coat F domain
BPOF4_RS07175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BPOF4_RS07180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BPOF4_RS07185	COG1120	ATPase activity
BPOF4_RS07190	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BPOF4_RS07195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BPOF4_RS07200	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
BPOF4_RS07205	COG1492	cobalamin metabolic process
BPOF4_RS07210	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BPOF4_RS07225	COG2096	Adenosyltransferase
BPOF4_RS07230	COG2720	vancomycin resistance protein
BPOF4_RS07250	COG0739	heme binding
BPOF4_RS07260	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BPOF4_RS07265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BPOF4_RS07275	COG1141	Ferredoxin
BPOF4_RS07285	COG0514	ATP-dependent DNA helicase (RecQ)
BPOF4_RS07310	COG1473	amidohydrolase
BPOF4_RS07330	COG1408	metallophosphoesterase
BPOF4_RS07335	COG0789	Transcriptional regulator
BPOF4_RS07340	COG4862	establishment of competence for transformation
BPOF4_RS07345	COG1181	Belongs to the D-alanine--D-alanine ligase family
BPOF4_RS07350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BPOF4_RS07355	COG0492	ferredoxin-NADP+ reductase activity
BPOF4_RS07360	COG0252	asparaginase activity
BPOF4_RS07365	COG2339	peptidase activity
BPOF4_RS07370	COG0626	cystathionine gamma-synthase activity
BPOF4_RS07375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BPOF4_RS07375	COG0646	methionine synthase
BPOF4_RS07380	COG1410	methionine synthase
BPOF4_RS07380	COG0646	methionine synthase
BPOF4_RS07385	COG3409	Peptidoglycan-binding domain 1 protein
BPOF4_RS07385	COG3773	Cell wall hydrolase
BPOF4_RS07390	COG2959	enzyme of heme biosynthesis
BPOF4_RS07400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BPOF4_RS07405	COG0204	Acyl-transferase
BPOF4_RS07415	COG1304	FMN binding
BPOF4_RS07425	COG1160	GTP binding
BPOF4_RS07430	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BPOF4_RS07435	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BPOF4_RS07455	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BPOF4_RS07465	COG0142	geranyltranstransferase activity
BPOF4_RS07470	COG2226	methyltransferase
BPOF4_RS07480	COG0163	prenyltransferase activity
BPOF4_RS07485	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BPOF4_RS07490	COG0142	geranyltranstransferase activity
BPOF4_RS07495	COG0105	UTP biosynthetic process
BPOF4_RS07500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BPOF4_RS07505	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BPOF4_RS07510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BPOF4_RS07515	COG4401	Chorismate mutase type I
BPOF4_RS07525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BPOF4_RS07530	COG0134	indole-3-glycerol-phosphate synthase activity
BPOF4_RS07535	COG0135	phosphoribosylanthranilate isomerase activity
BPOF4_RS07540	COG0133	tryptophan synthase activity
BPOF4_RS07545	COG0159	tryptophan synthase activity
BPOF4_RS07550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BPOF4_RS07555	COG0287	Prephenate dehydrogenase
BPOF4_RS07560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BPOF4_RS07570	COG0457	Tetratricopeptide repeat
BPOF4_RS07575	COG5582	Belongs to the UPF0302 family
BPOF4_RS07585	COG0723	plastoquinol--plastocyanin reductase activity
BPOF4_RS07590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BPOF4_RS07595	COG2010	Cytochrome c
BPOF4_RS07595	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BPOF4_RS07600	COG4347	Protein of unknown function (DUF1405)
BPOF4_RS07610	COG2738	Putative neutral zinc metallopeptidase
BPOF4_RS07615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BPOF4_RS07620	COG1694	Mazg nucleotide pyrophosphohydrolase
BPOF4_RS07625	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BPOF4_RS07630	COG1803	Methylglyoxal synthase
BPOF4_RS07635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BPOF4_RS07640	COG0438	transferase activity, transferring glycosyl groups
BPOF4_RS07645	COG0617	tRNA 3'-terminal CCA addition
BPOF4_RS07660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BPOF4_RS07665	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BPOF4_RS07670	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BPOF4_RS07680	COG1199	ATP-dependent helicase activity
BPOF4_RS07680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BPOF4_RS07690	COG0402	S-adenosylhomocysteine deaminase activity
BPOF4_RS07700	COG0436	Aminotransferase
BPOF4_RS07705	COG0017	Asparaginyl-tRNA synthetase
BPOF4_RS07710	COG3935	DnaD domain protein
BPOF4_RS07715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BPOF4_RS07725	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BPOF4_RS07735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BPOF4_RS07735	COG4499	WXG100 protein secretion system (Wss), protein YukC
BPOF4_RS07740	COG3331	DNA recombination
BPOF4_RS07750	COG0789	Transcriptional regulator
BPOF4_RS07765	COG2860	membrane
BPOF4_RS07775	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BPOF4_RS07780	COG0784	Response regulator, receiver
BPOF4_RS07780	COG0835	chemotaxis
BPOF4_RS07785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BPOF4_RS07790	COG1234	tRNA 3'-trailer cleavage
BPOF4_RS07820	COG1413	lyase activity
BPOF4_RS07830	COG3402	PFAM membrane-flanked domain
BPOF4_RS07835	COG3428	Bacterial PH domain
BPOF4_RS07845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BPOF4_RS07865	COG0067	glutamate synthase
BPOF4_RS07865	COG0069	glutamate synthase activity
BPOF4_RS07865	COG0070	glutamate synthase
BPOF4_RS07870	COG0493	'glutamate synthase
BPOF4_RS07900	COG2508	Transcriptional regulator
BPOF4_RS07910	COG0460	homoserine dehydrogenase
BPOF4_RS07915	COG1012	belongs to the aldehyde dehydrogenase family
BPOF4_RS07920	COG0006	proline dipeptidase activity
BPOF4_RS07930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BPOF4_RS07945	COG0561	phosphatase activity
BPOF4_RS07955	COG1278	Cold shock
BPOF4_RS07960	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BPOF4_RS07965	COG1278	Cold shock
BPOF4_RS07970	COG0789	Transcriptional regulator
BPOF4_RS07975	COG1960	acyl-CoA dehydrogenase activity
BPOF4_RS08005	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BPOF4_RS08010	COG1205	dead DEAH box helicase
BPOF4_RS08010	COG1111	helicase
BPOF4_RS08015	COG3359	exonuclease
BPOF4_RS08025	COG4474	Belongs to the UPF0398 family
BPOF4_RS08030	COG3599	regulation of cell shape
BPOF4_RS08035	COG0328	RNA-DNA hybrid ribonuclease activity
BPOF4_RS08040	COG0116	Belongs to the methyltransferase superfamily
BPOF4_RS08055	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BPOF4_RS08065	COG5522	Integral membrane protein (intg_mem_TP0381)
BPOF4_RS08070	COG4974	Belongs to the 'phage' integrase family
BPOF4_RS08075	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
BPOF4_RS08080	COG0156	8-amino-7-oxononanoate synthase activity
BPOF4_RS08085	COG2124	cytochrome p450
BPOF4_RS08090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BPOF4_RS08095	COG0183	Belongs to the thiolase family
BPOF4_RS08100	COG3290	protein histidine kinase activity
BPOF4_RS08100	COG3829	transcription factor binding
BPOF4_RS08110	COG2610	gluconate transmembrane transporter activity
BPOF4_RS08115	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS08120	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS08125	COG0517	IMP dehydrogenase activity
BPOF4_RS08125	COG1125	glycine betaine transport
BPOF4_RS08130	COG1174	glycine betaine transport
BPOF4_RS08140	COG1832	CoA-binding protein
BPOF4_RS08150	COG0187	DNA topoisomerase II activity
BPOF4_RS08155	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BPOF4_RS08160	COG0628	permease
BPOF4_RS08170	COG0596	Alpha beta hydrolase
BPOF4_RS08185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BPOF4_RS08200	COG0596	Alpha beta hydrolase
BPOF4_RS08205	COG0406	alpha-ribazole phosphatase activity
BPOF4_RS08240	COG1012	belongs to the aldehyde dehydrogenase family
BPOF4_RS08250	COG0110	maltose O-acetyltransferase activity
BPOF4_RS08255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BPOF4_RS08265	COG3037	sugar-specific permease SgaT UlaA
BPOF4_RS08295	COG0076	glutamate decarboxylase activity
BPOF4_RS08320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BPOF4_RS08325	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BPOF4_RS08335	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS08345	COG2226	methyltransferase
BPOF4_RS08355	COG1595	DNA-templated transcription, initiation
BPOF4_RS08360	COG1366	Belongs to the anti-sigma-factor antagonist family
BPOF4_RS08385	COG1595	DNA-templated transcription, initiation
BPOF4_RS08440	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BPOF4_RS08440	COG0456	acetyltransferase
BPOF4_RS08490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BPOF4_RS08515	COG1104	cysteine desulfurase activity
BPOF4_RS08520	COG0697	spore germination
BPOF4_RS08525	COG1366	Belongs to the anti-sigma-factor antagonist family
BPOF4_RS08550	COG1131	(ABC) transporter
BPOF4_RS08570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BPOF4_RS08575	COG0010	Belongs to the arginase family
BPOF4_RS08580	COG1228	amidohydrolase
BPOF4_RS08585	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BPOF4_RS08610	COG0737	Belongs to the 5'-nucleotidase family
BPOF4_RS08640	COG2056	Na+-H+ antiporter family
BPOF4_RS08645	COG2986	histidine ammonia-lyase
BPOF4_RS08675	COG2153	protein acetylation
BPOF4_RS08680	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BPOF4_RS08705	COG0662	Cupin 2, conserved barrel domain protein
BPOF4_RS08710	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BPOF4_RS08720	COG3546	catalase activity
BPOF4_RS08735	COG0300	oxidoreductase activity
BPOF4_RS08785	COG1253	flavin adenine dinucleotide binding
BPOF4_RS08795	COG0577	efflux transmembrane transporter activity
BPOF4_RS08800	COG1136	(ABC) transporter
BPOF4_RS08805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BPOF4_RS08810	COG1253	flavin adenine dinucleotide binding
BPOF4_RS08825	COG1408	metallophosphoesterase
BPOF4_RS08830	COG4608	Belongs to the ABC transporter superfamily
BPOF4_RS08845	COG0601	transmembrane transport
BPOF4_RS08855	COG0717	Belongs to the dCTP deaminase family
BPOF4_RS08860	COG0523	cobalamin synthesis protein
BPOF4_RS08865	COG1012	belongs to the aldehyde dehydrogenase family
BPOF4_RS08870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BPOF4_RS08875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BPOF4_RS08880	COG3973	AAA domain
BPOF4_RS08895	COG0322	excinuclease ABC activity
BPOF4_RS08900	COG1278	Cold shock
BPOF4_RS08920	COG4978	Transcriptional regulator
BPOF4_RS08920	COG0789	Transcriptional regulator
BPOF4_RS08925	COG2211	Major facilitator Superfamily
BPOF4_RS08970	COG1366	Belongs to the anti-sigma-factor antagonist family
BPOF4_RS08980	COG1329	Transcriptional regulator
BPOF4_RS08995	COG2135	peptidase activity
BPOF4_RS09035	COG1061	Type III restriction enzyme res subunit
BPOF4_RS09045	COG1484	DNA-dependent DNA replication
BPOF4_RS09050	COG2390	Transcriptional regulator
BPOF4_RS09050	COG4584	PFAM Integrase catalytic
BPOF4_RS09065	COG0537	adenosine 5'-monophosphoramidase activity
BPOF4_RS09075	COG0494	nUDIX hydrolase
BPOF4_RS09110	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BPOF4_RS09125	COG2195	Cleaves the N-terminal amino acid of tripeptides
BPOF4_RS09220	COG0494	nUDIX hydrolase
BPOF4_RS09235	COG2202	Pas domain
BPOF4_RS09235	COG1366	Belongs to the anti-sigma-factor antagonist family
BPOF4_RS09285	COG1366	Belongs to the anti-sigma-factor antagonist family
BPOF4_RS09315	COG0733	neurotransmitter:sodium symporter activity
BPOF4_RS09355	COG3173	Aminoglycoside phosphotransferase
BPOF4_RS09380	COG2259	Doxx family
BPOF4_RS09385	COG2514	catechol 2,3-dioxygenase activity
BPOF4_RS09390	COG1733	regulation of RNA biosynthetic process
BPOF4_RS09410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BPOF4_RS09410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BPOF4_RS09440	COG2207	Transcriptional regulator
BPOF4_RS09440	COG3708	Transcriptional regulator
BPOF4_RS09455	COG0534	Mate efflux family protein
BPOF4_RS09485	COG0464	growth
BPOF4_RS09495	COG1595	DNA-templated transcription, initiation
BPOF4_RS09505	COG0604	alcohol dehydrogenase
BPOF4_RS09510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BPOF4_RS09535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BPOF4_RS09545	COG0659	secondary active sulfate transmembrane transporter activity
BPOF4_RS09550	COG0318	PFAM AMP-dependent synthetase and ligase
BPOF4_RS09560	COG0183	Belongs to the thiolase family
BPOF4_RS09610	COG1522	sequence-specific DNA binding
BPOF4_RS09655	COG2304	oxidoreductase activity
BPOF4_RS09670	COG1253	flavin adenine dinucleotide binding
BPOF4_RS09695	COG0842	Transport permease protein
BPOF4_RS09705	COG1131	(ABC) transporter
BPOF4_RS09710	COG2197	response regulator
BPOF4_RS09715	COG4585	Histidine kinase
BPOF4_RS09740	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
BPOF4_RS09745	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
BPOF4_RS09755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BPOF4_RS09760	COG0318	PFAM AMP-dependent synthetase and ligase
BPOF4_RS09765	COG3876	Protein conserved in bacteria
BPOF4_RS09770	COG1472	Belongs to the glycosyl hydrolase 3 family
BPOF4_RS09780	COG1263	PTS System
BPOF4_RS09780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BPOF4_RS09785	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BPOF4_RS09790	COG1737	Transcriptional regulator
BPOF4_RS09825	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BPOF4_RS09850	COG1609	Transcriptional regulator
BPOF4_RS09860	COG5578	integral membrane protein
BPOF4_RS09865	COG0395	ABC-type sugar transport system, permease component
BPOF4_RS09870	COG1175	transmembrane transport
BPOF4_RS09880	COG2723	6-phospho-beta-galactosidase activity
BPOF4_RS09900	COG2217	Heavy metal translocating P-type atpase
BPOF4_RS09910	COG1937	Protein conserved in bacteria
BPOF4_RS09915	COG1120	ATPase activity
BPOF4_RS09920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BPOF4_RS09925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BPOF4_RS09930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BPOF4_RS09945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BPOF4_RS09950	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS09955	COG0798	PFAM Bile acid sodium symporter
BPOF4_RS09965	COG3493	citrate carrier protein
BPOF4_RS09980	COG3290	protein histidine kinase activity
BPOF4_RS09985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BPOF4_RS09995	COG0659	secondary active sulfate transmembrane transporter activity
BPOF4_RS10025	COG2318	DinB family
BPOF4_RS10035	COG0402	S-adenosylhomocysteine deaminase activity
BPOF4_RS10045	COG0583	DNA-binding transcription factor activity
BPOF4_RS10060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BPOF4_RS10070	COG2312	Erythromycin esterase
BPOF4_RS10090	COG0515	serine threonine protein kinase
BPOF4_RS10090	COG2815	serine threonine protein kinase
BPOF4_RS10120	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BPOF4_RS10125	COG0785	Cytochrome C biogenesis protein
BPOF4_RS10155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BPOF4_RS10160	COG2808	Putative FMN-binding domain
BPOF4_RS10175	COG2323	membrane
BPOF4_RS10180	COG4821	SIS domain
BPOF4_RS10185	COG2188	Transcriptional regulator
BPOF4_RS10190	COG0363	glucosamine-6-phosphate deaminase activity
BPOF4_RS10195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BPOF4_RS10200	COG1263	PTS System
BPOF4_RS10200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BPOF4_RS10230	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BPOF4_RS10235	COG4145	pantothenate transmembrane transporter activity
BPOF4_RS10245	COG2720	vancomycin resistance protein
BPOF4_RS10255	COG1388	LysM domain
BPOF4_RS10255	COG3858	chitin binding
BPOF4_RS10265	COG0432	Pfam Uncharacterised protein family UPF0047
BPOF4_RS10270	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BPOF4_RS10275	COG1793	dna ligase
BPOF4_RS10275	COG3285	dna ligase
BPOF4_RS10280	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BPOF4_RS10285	COG4988	ABC transporter
BPOF4_RS10305	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BPOF4_RS10310	COG5002	protein histidine kinase activity
BPOF4_RS10315	COG0745	RESPONSE REGULATOR receiver
BPOF4_RS10335	COG0840	transmembrane signaling receptor activity
BPOF4_RS10345	COG0183	Belongs to the thiolase family
BPOF4_RS10350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BPOF4_RS10365	COG2340	Cysteine-rich secretory protein family
BPOF4_RS10370	COG1215	transferase activity, transferring glycosyl groups
BPOF4_RS10400	COG0561	phosphatase activity
BPOF4_RS10415	COG0708	Exodeoxyribonuclease III
BPOF4_RS10420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BPOF4_RS10425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BPOF4_RS10430	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BPOF4_RS10435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BPOF4_RS10445	COG1509	lysine 2,3-aminomutase activity
BPOF4_RS10450	COG0456	acetyltransferase
BPOF4_RS10455	COG3829	transcription factor binding
BPOF4_RS10465	COG0655	NAD(P)H dehydrogenase (quinone) activity
BPOF4_RS10470	COG1199	ATP-dependent helicase activity
BPOF4_RS10475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BPOF4_RS10490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BPOF4_RS10500	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BPOF4_RS10520	COG1597	lipid kinase activity
BPOF4_RS10530	COG2094	Belongs to the DNA glycosylase MPG family
BPOF4_RS10535	COG0604	alcohol dehydrogenase
BPOF4_RS10540	COG1587	Uroporphyrinogen-III synthase
BPOF4_RS10545	COG1164	Oligoendopeptidase f
BPOF4_RS10565	COG3069	C4-dicarboxylate transmembrane transporter activity
BPOF4_RS10590	COG0436	Aminotransferase
BPOF4_RS10610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BPOF4_RS10615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BPOF4_RS10625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BPOF4_RS10640	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BPOF4_RS10650	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BPOF4_RS10675	COG3118	belongs to the thioredoxin family
BPOF4_RS10685	COG0514	ATP-dependent DNA helicase (RecQ)
BPOF4_RS10695	COG0488	(ABC) transporter
BPOF4_RS10700	COG0180	Tryptophanyl-tRNA synthetase
BPOF4_RS10705	COG0697	spore germination
BPOF4_RS10715	COG0586	Pfam SNARE associated Golgi protein
BPOF4_RS10725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BPOF4_RS10730	COG0508	dehydrogenase complex catalyzes the overall conversion of
BPOF4_RS10735	COG0567	Dehydrogenase, E1 component
BPOF4_RS10745	COG2391	methyltransferase activity
BPOF4_RS10755	COG0778	Nitroreductase
BPOF4_RS10765	COG0500	methyltransferase
BPOF4_RS10770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BPOF4_RS10810	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BPOF4_RS10820	COG0720	synthase
BPOF4_RS10825	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BPOF4_RS10830	COG2309	aminopeptidase activity
BPOF4_RS10850	COG1309	transcriptional regulator
BPOF4_RS10860	COG0657	acetylesterase activity
BPOF4_RS10865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BPOF4_RS10885	COG4841	protein insertion into membrane
BPOF4_RS10895	COG0835	chemotaxis
BPOF4_RS10895	COG0784	Response regulator, receiver
BPOF4_RS10910	COG0071	Belongs to the small heat shock protein (HSP20) family
BPOF4_RS10940	COG2200	EAL domain
BPOF4_RS10945	COG2267	carboxylic ester hydrolase activity
BPOF4_RS10950	COG2770	Histidine kinase
BPOF4_RS10950	COG3437	response regulator, receiver
BPOF4_RS10955	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BPOF4_RS10975	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BPOF4_RS10995	COG0824	Thioesterase
BPOF4_RS11000	COG0464	growth
BPOF4_RS11005	COG0697	spore germination
BPOF4_RS11020	COG0398	Pfam SNARE associated Golgi protein
BPOF4_RS11035	COG2323	membrane
BPOF4_RS11055	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BPOF4_RS11075	COG1607	acyl-coa hydrolase
BPOF4_RS11095	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BPOF4_RS11105	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BPOF4_RS11130	COG1408	metallophosphoesterase
BPOF4_RS11140	COG4499	WXG100 protein secretion system (Wss), protein YukC
BPOF4_RS11140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BPOF4_RS11145	COG1388	LysM domain
BPOF4_RS11145	COG3584	3D domain protein
BPOF4_RS11160	COG0686	Belongs to the AlaDH PNT family
BPOF4_RS11170	COG4846	Membrane protein involved in cytochrome C biogenesis
BPOF4_RS11180	COG1132	(ABC) transporter
BPOF4_RS11185	COG1132	(ABC) transporter
BPOF4_RS11190	COG3763	UPF0154 protein
BPOF4_RS11200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BPOF4_RS11205	COG4224	UPF0291 protein
BPOF4_RS11210	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BPOF4_RS11220	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BPOF4_RS11240	COG0174	glutamine synthetase
BPOF4_RS11245	COG0789	Transcriptional regulator
BPOF4_RS11250	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BPOF4_RS11255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BPOF4_RS11260	COG0464	growth
BPOF4_RS11270	COG1923	regulation of RNA biosynthetic process
BPOF4_RS11275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BPOF4_RS11280	COG2136	Putative SAM-dependent methyltransferase
BPOF4_RS11280	COG2521	methyltransferase
BPOF4_RS11285	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BPOF4_RS11290	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BPOF4_RS11300	COG4550	Control of competence regulator ComK, YlbF/YmcA
BPOF4_RS11305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BPOF4_RS11310	COG1013	pyruvate-flavodoxin oxidoreductase activity
BPOF4_RS11315	COG0674	pyruvate-flavodoxin oxidoreductase activity
BPOF4_RS11315	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BPOF4_RS11320	COG2359	stage V sporulation protein S
BPOF4_RS11325	COG1692	metallophosphoesterase
BPOF4_RS11330	COG1418	mRNA catabolic process
BPOF4_RS11345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BPOF4_RS11355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BPOF4_RS11360	COG0513	Belongs to the DEAD box helicase family
BPOF4_RS11365	COG1058	Belongs to the CinA family
BPOF4_RS11365	COG1546	Belongs to the CinA family
BPOF4_RS11370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BPOF4_RS11375	COG1666	GTP binding
BPOF4_RS11380	COG1426	Protein conserved in bacteria
BPOF4_RS11395	COG0300	oxidoreductase activity
BPOF4_RS11400	COG0612	Peptidase, M16
BPOF4_RS11405	COG0612	Peptidase, M16
BPOF4_RS11410	COG2188	Transcriptional regulator
BPOF4_RS11415	COG1674	ftsk spoiiie
BPOF4_RS11425	COG0740	serine-type endopeptidase activity
BPOF4_RS11430	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BPOF4_RS11435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BPOF4_RS11440	COG0527	aspartate kinase activity
BPOF4_RS11445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BPOF4_RS11450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BPOF4_RS11455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BPOF4_RS11460	COG1873	PFAM PRC-barrel domain
BPOF4_RS11465	COG0612	Peptidase, M16
BPOF4_RS11470	COG0726	polysaccharide deacetylase
BPOF4_RS11475	COG1185	polyribonucleotide nucleotidyltransferase activity
BPOF4_RS11480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BPOF4_RS11485	COG0196	riboflavin kinase activity
BPOF4_RS11490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BPOF4_RS11495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BPOF4_RS11505	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BPOF4_RS11510	COG1358	cellular component organization or biogenesis
BPOF4_RS11515	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BPOF4_RS11520	COG0195	Participates in both transcription termination and antitermination
BPOF4_RS11525	COG0779	Required for maturation of 30S ribosomal subunits
BPOF4_RS11530	COG2176	DNA-directed DNA polymerase activity
BPOF4_RS11535	COG0442	prolyl-tRNA aminoacylation
BPOF4_RS11540	COG0750	zinc metalloprotease
BPOF4_RS11545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BPOF4_RS11550	COG4589	Belongs to the CDS family
BPOF4_RS11555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BPOF4_RS11560	COG0233	cytoplasmic translational termination
BPOF4_RS11565	COG0528	UMP kinase activity
BPOF4_RS11570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BPOF4_RS11575	COG0052	Belongs to the universal ribosomal protein uS2 family
BPOF4_RS11595	COG1191	sigma factor activity
BPOF4_RS11600	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BPOF4_RS11605	COG1776	CheC inhibitor of MCP methylation
BPOF4_RS11610	COG2201	protein-glutamate methylesterase activity
BPOF4_RS11615	COG0455	bacterial-type flagellum organization
BPOF4_RS11620	COG1419	protein localization to endoplasmic reticulum
BPOF4_RS11625	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BPOF4_RS11630	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BPOF4_RS11635	COG1684	flagellar biosynthetic protein fliR
BPOF4_RS11640	COG1987	bacterial-type flagellum assembly
BPOF4_RS11645	COG1338	Plays a role in the flagellum-specific transport system
BPOF4_RS11655	COG2201	protein-glutamate methylesterase activity
BPOF4_RS11660	COG1776	CheC inhibitor of MCP methylation
BPOF4_RS11660	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BPOF4_RS11665	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BPOF4_RS11675	COG1582	Flagellar protein (FlbD)
BPOF4_RS11680	COG4786	Flagellar basal body rod
BPOF4_RS11690	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BPOF4_RS11710	COG1157	protein secretion by the type III secretion system
BPOF4_RS11715	COG1317	bacterial-type flagellum organization
BPOF4_RS11720	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BPOF4_RS11725	COG1766	The M ring may be actively involved in energy transduction
BPOF4_RS11730	COG1677	Flagellar hook-basal body complex protein FliE
BPOF4_RS11735	COG1558	bacterial-type flagellum-dependent cell motility
BPOF4_RS11740	COG1815	bacterial-type flagellum-dependent cell motility
BPOF4_RS11745	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BPOF4_RS11750	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BPOF4_RS11755	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BPOF4_RS11760	COG4974	Belongs to the 'phage' integrase family
BPOF4_RS11765	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BPOF4_RS11770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BPOF4_RS11775	COG0758	DNA mediated transformation
BPOF4_RS11780	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BPOF4_RS11785	COG0045	succinate-CoA ligase (ADP-forming) activity
BPOF4_RS11790	COG2257	FlhB HrpN YscU SpaS Family
BPOF4_RS11800	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BPOF4_RS11815	COG0335	large ribosomal subunit rRNA binding
BPOF4_RS11820	COG0336	Belongs to the RNA methyltransferase TrmD family
BPOF4_RS11825	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BPOF4_RS11835	COG1837	Belongs to the UPF0109 family
BPOF4_RS11840	COG0228	four-way junction DNA binding
BPOF4_RS11845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BPOF4_RS11850	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BPOF4_RS11855	COG0552	protein localization to endoplasmic reticulum
BPOF4_RS11860	COG1196	nuclear chromosome segregation
BPOF4_RS11865	COG4840	Belongs to the UPF0435 family
BPOF4_RS11870	COG0571	ribonuclease III activity
BPOF4_RS11875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BPOF4_RS11880	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS11885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BPOF4_RS11890	COG0416	fatty acid biosynthetic process
BPOF4_RS11895	COG1349	DNA-binding transcription factor activity
BPOF4_RS11900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BPOF4_RS11905	COG1760	l-serine dehydratase
BPOF4_RS11910	COG1760	l-serine dehydratase
BPOF4_RS11915	COG1307	EDD domain protein, DegV family
BPOF4_RS11920	COG1461	Dihydroxyacetone kinase
BPOF4_RS11925	COG1302	Protein conserved in bacteria
BPOF4_RS11930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BPOF4_RS11940	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BPOF4_RS11945	COG1162	GTPase activity
BPOF4_RS11950	COG0515	serine threonine protein kinase
BPOF4_RS11950	COG2815	serine threonine protein kinase
BPOF4_RS11955	COG0631	protein serine/threonine phosphatase activity
BPOF4_RS11960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BPOF4_RS11960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BPOF4_RS11965	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BPOF4_RS11970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BPOF4_RS11975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BPOF4_RS11980	COG1758	RNA polymerase activity
BPOF4_RS11985	COG0194	GDP metabolic process
BPOF4_RS11990	COG2052	Domain of unknown function (DUF370)
BPOF4_RS11995	COG1561	YicC-like family, N-terminal region
BPOF4_RS12000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BPOF4_RS12010	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BPOF4_RS12015	COG2223	nitrite transmembrane transporter activity
BPOF4_RS12020	COG5609	conserved protein (DUF2294)
BPOF4_RS12035	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BPOF4_RS12040	COG0284	orotidine-5'-phosphate decarboxylase activity
BPOF4_RS12045	COG0167	dihydroorotate dehydrogenase activity
BPOF4_RS12050	COG0543	2 iron, 2 sulfur cluster binding
BPOF4_RS12055	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BPOF4_RS12060	COG0505	Belongs to the CarA family
BPOF4_RS12065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BPOF4_RS12070	COG0540	Belongs to the ATCase OTCase family
BPOF4_RS12075	COG2233	PERMEase
BPOF4_RS12080	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BPOF4_RS12085	COG0564	pseudouridine synthase activity
BPOF4_RS12090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BPOF4_RS12095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BPOF4_RS12100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BPOF4_RS12105	COG3599	regulation of cell shape
BPOF4_RS12110	COG2302	S4 RNA-binding domain
BPOF4_RS12115	COG0762	integral membrane protein
BPOF4_RS12120	COG1799	cell septum assembly
BPOF4_RS12125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BPOF4_RS12130	COG1496	oxidoreductase activity
BPOF4_RS12135	COG1873	PFAM PRC-barrel domain
BPOF4_RS12140	COG1191	sigma factor activity
BPOF4_RS12145	COG1191	sigma factor activity
BPOF4_RS12155	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BPOF4_RS12160	COG0849	cell division
BPOF4_RS12165	COG3856	small basic protein
BPOF4_RS12170	COG3879	Bacterial protein of unknown function (DUF881)
BPOF4_RS12175	COG3879	Bacterial protein of unknown function (DUF881)
BPOF4_RS12180	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BPOF4_RS12185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BPOF4_RS12190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BPOF4_RS12195	COG0772	Belongs to the SEDS family
BPOF4_RS12200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BPOF4_RS12205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BPOF4_RS12210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BPOF4_RS12215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BPOF4_RS12220	COG0768	penicillin binding
BPOF4_RS12225	COG0768	penicillin binding
BPOF4_RS12235	COG0275	rRNA processing
BPOF4_RS12240	COG2001	Belongs to the MraZ family
BPOF4_RS12245	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BPOF4_RS12255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BPOF4_RS12260	COG0454	-acetyltransferase
BPOF4_RS12270	COG1024	Enoyl-CoA hydratase
BPOF4_RS12275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BPOF4_RS12280	COG1399	metal-binding, possibly nucleic acid-binding protein
BPOF4_RS12285	COG1323	Belongs to the UPF0348 family
BPOF4_RS12290	COG3480	Lon protease (S16) C-terminal proteolytic domain
BPOF4_RS12295	COG1752	Esterase of the alpha-beta hydrolase superfamily
BPOF4_RS12300	COG3314	Sporulation integral membrane protein YlbJ
BPOF4_RS12305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BPOF4_RS12310	COG0742	ribosomal rna small subunit methyltransferase
BPOF4_RS12320	COG2814	Major facilitator Superfamily
BPOF4_RS12325	COG4471	UPF0298 protein
BPOF4_RS12335	COG3679	Belongs to the UPF0342 family
BPOF4_RS12340	COG4294	response to UV
BPOF4_RS12370	COG2340	Cysteine-rich secretory protein family
BPOF4_RS12395	COG0628	permease
BPOF4_RS12400	COG2322	membrane
BPOF4_RS12405	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BPOF4_RS12410	COG1845	cytochrome c oxidase, subunit III
BPOF4_RS12415	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BPOF4_RS12420	COG2010	Cytochrome c
BPOF4_RS12420	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BPOF4_RS12425	COG0109	protoheme IX farnesyltransferase activity
BPOF4_RS12430	COG1612	heme a metabolic process
BPOF4_RS12435	COG0415	Belongs to the DNA photolyase family
BPOF4_RS12440	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BPOF4_RS12450	COG4838	Belongs to the UPF0358 family
BPOF4_RS12455	COG2066	Belongs to the glutaminase family
BPOF4_RS12460	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BPOF4_RS12465	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BPOF4_RS12475	COG4896	Protein conserved in bacteria
BPOF4_RS12485	COG1217	gtp-binding protein TYPA
BPOF4_RS12495	COG0483	inositol monophosphate 1-phosphatase activity
BPOF4_RS12505	COG4493	Belongs to the UPF0637 family
BPOF4_RS12510	COG4476	Belongs to the UPF0223 family
BPOF4_RS12520	COG1982	Orn Lys Arg decarboxylase major
BPOF4_RS12535	COG0726	polysaccharide deacetylase
BPOF4_RS12540	COG4129	membrane
BPOF4_RS12545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BPOF4_RS12570	COG0022	dehydrogenase e1 component
BPOF4_RS12590	COG0242	peptide deformylase activity
BPOF4_RS12595	COG5503	Protein of unknown function (DUF1447)
BPOF4_RS12600	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BPOF4_RS12605	COG0569	domain protein
BPOF4_RS12610	COG0450	alkyl hydroperoxide reductase
BPOF4_RS12615	COG0668	transmembrane transport
BPOF4_RS12630	COG1473	amidohydrolase
BPOF4_RS12635	COG2171	N-acyltransferase activity
BPOF4_RS12645	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BPOF4_RS12645	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BPOF4_RS12650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BPOF4_RS12650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BPOF4_RS12655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BPOF4_RS12660	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BPOF4_RS12665	COG1737	Transcriptional regulator
BPOF4_RS12670	COG1070	Carbohydrate kinase
BPOF4_RS12675	COG2224	Isocitrate lyase
BPOF4_RS12685	COG2814	Major facilitator Superfamily
BPOF4_RS12690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BPOF4_RS12695	COG0668	transmembrane transport
BPOF4_RS12705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BPOF4_RS12710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BPOF4_RS12740	COG1797	cobyrinic acid a,c-diamide synthase activity
BPOF4_RS12760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BPOF4_RS12760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BPOF4_RS12765	COG2210	Belongs to the sulfur carrier protein TusA family
BPOF4_RS12790	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
BPOF4_RS12800	COG0309	Hydrogenase expression formation protein (HypE)
BPOF4_RS12805	COG0409	Hydrogenase expression formation protein
BPOF4_RS12810	COG0298	carbon dioxide binding
BPOF4_RS12815	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BPOF4_RS12820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BPOF4_RS12825	COG0375	protein maturation
BPOF4_RS12830	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BPOF4_RS12835	COG3383	formate dehydrogenase (NAD+) activity
BPOF4_RS12840	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BPOF4_RS12860	COG4191	Histidine kinase
BPOF4_RS12865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BPOF4_RS12905	COG0508	dehydrogenase complex catalyzes the overall conversion of
BPOF4_RS12910	COG0022	dehydrogenase e1 component
BPOF4_RS12915	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BPOF4_RS12920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BPOF4_RS12925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BPOF4_RS12930	COG3829	transcription factor binding
BPOF4_RS12930	COG3290	protein histidine kinase activity
BPOF4_RS12945	COG1215	transferase activity, transferring glycosyl groups
BPOF4_RS12955	COG0745	RESPONSE REGULATOR receiver
BPOF4_RS12970	COG0750	zinc metalloprotease
BPOF4_RS12975	COG0497	DNA recombination
BPOF4_RS12980	COG1438	arginine binding
BPOF4_RS12985	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BPOF4_RS12990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BPOF4_RS13000	COG0142	geranyltranstransferase activity
BPOF4_RS13005	COG1722	exodeoxyribonuclease VII activity
BPOF4_RS13010	COG1570	exodeoxyribonuclease VII activity
BPOF4_RS13015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BPOF4_RS13020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BPOF4_RS13025	COG1302	Protein conserved in bacteria
BPOF4_RS13030	COG0439	Biotin carboxylase
BPOF4_RS13035	COG0511	ligase activity, forming carbon-carbon bonds
BPOF4_RS13080	COG3854	ATPases associated with a variety of cellular activities
BPOF4_RS13090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BPOF4_RS13095	COG0006	proline dipeptidase activity
BPOF4_RS13100	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BPOF4_RS13115	COG1752	Esterase of the alpha-beta hydrolase superfamily
BPOF4_RS13120	COG1321	iron dependent repressor
BPOF4_RS13125	COG1533	DNA photolyase activity
BPOF4_RS13130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BPOF4_RS13140	COG0095	Lipoate-protein ligase
BPOF4_RS13145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BPOF4_RS13150	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BPOF4_RS13155	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BPOF4_RS13160	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BPOF4_RS13165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BPOF4_RS13180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BPOF4_RS13195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BPOF4_RS13220	COG4537	Required for transformation and DNA binding
BPOF4_RS13225	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BPOF4_RS13310	COG1459	type II secretion system
BPOF4_RS13315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BPOF4_RS13325	COG1970	mechanosensitive ion channel activity
BPOF4_RS13330	COG1403	HNH endonuclease
BPOF4_RS13340	COG0210	DNA helicase
BPOF4_RS13345	COG1418	mRNA catabolic process
BPOF4_RS13375	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BPOF4_RS13390	COG0589	response to stress
BPOF4_RS13390	COG0475	glutathione-regulated potassium exporter activity
BPOF4_RS13395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BPOF4_RS13405	COG0564	pseudouridine synthase activity
BPOF4_RS13410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BPOF4_RS13415	COG2357	RelA SpoT domain protein
BPOF4_RS13435	COG0243	molybdopterin cofactor binding
BPOF4_RS13440	COG2346	COG2346, Truncated hemoglobins
BPOF4_RS13445	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BPOF4_RS13450	COG1164	Oligoendopeptidase f
BPOF4_RS13455	COG4469	Competence protein
BPOF4_RS13460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BPOF4_RS13465	COG4862	establishment of competence for transformation
BPOF4_RS13470	COG0861	Integral membrane protein TerC family
BPOF4_RS13475	COG1393	Belongs to the ArsC family
BPOF4_RS13480	COG0456	acetyltransferase
BPOF4_RS13495	COG1272	protein, Hemolysin III
BPOF4_RS13500	COG1418	mRNA catabolic process
BPOF4_RS13505	COG0530	calcium, potassium:sodium antiporter activity
BPOF4_RS13520	COG1063	alcohol dehydrogenase
BPOF4_RS13535	COG0180	Tryptophanyl-tRNA synthetase
BPOF4_RS13560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BPOF4_RS13565	COG0400	carboxylic ester hydrolase activity
BPOF4_RS13570	COG0346	lactoylglutathione lyase activity
BPOF4_RS13580	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
BPOF4_RS13585	COG1072	(Pantothenic acid kinase))
BPOF4_RS13590	COG1686	Belongs to the peptidase S11 family
BPOF4_RS13595	COG2340	Cysteine-rich secretory protein family
BPOF4_RS13600	COG3773	Cell wall hydrolase
BPOF4_RS13610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BPOF4_RS13610	COG3620	sequence-specific DNA binding
BPOF4_RS13610	COG0617	tRNA 3'-terminal CCA addition
BPOF4_RS13615	COG0427	acetyl-CoA hydrolase
BPOF4_RS13625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BPOF4_RS13630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BPOF4_RS13655	COG1744	ABC transporter substrate-binding protein PnrA-like
BPOF4_RS13660	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BPOF4_RS13680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BPOF4_RS13685	COG2267	carboxylic ester hydrolase activity
BPOF4_RS13695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BPOF4_RS13700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BPOF4_RS13705	COG0505	Belongs to the CarA family
BPOF4_RS13715	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BPOF4_RS13720	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BPOF4_RS13725	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BPOF4_RS13740	COG1999	signal sequence binding
BPOF4_RS13745	COG3336	cytochrome c oxidase
BPOF4_RS13750	COG0561	phosphatase activity
BPOF4_RS13770	COG1966	Carbon starvation protein
BPOF4_RS13775	COG3279	Response regulator of the LytR AlgR family
BPOF4_RS13780	COG3275	phosphorelay sensor kinase activity
BPOF4_RS13785	COG1396	sequence-specific DNA binding
BPOF4_RS13790	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BPOF4_RS13805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BPOF4_RS13820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BPOF4_RS13825	COG1073	alpha beta
BPOF4_RS13840	COG0425	Belongs to the sulfur carrier protein TusA family
BPOF4_RS13840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BPOF4_RS13845	COG0628	permease
BPOF4_RS13850	COG1609	Transcriptional regulator
BPOF4_RS13855	COG3833	ABC-type maltose transport systems, permease component
BPOF4_RS13860	COG1175	transmembrane transport
BPOF4_RS13870	COG0366	Alpha amylase catalytic
BPOF4_RS13880	COG0534	Mate efflux family protein
BPOF4_RS13890	COG2358	TRAP transporter, solute receptor (TAXI family
BPOF4_RS13905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BPOF4_RS13915	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS13930	COG2358	TRAP transporter, solute receptor (TAXI family
BPOF4_RS13935	COG2204	response regulator
BPOF4_RS13940	COG5002	protein histidine kinase activity
BPOF4_RS13950	COG0778	Nitroreductase
BPOF4_RS13965	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BPOF4_RS13965	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BPOF4_RS13975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BPOF4_RS13980	COG0511	ligase activity, forming carbon-carbon bonds
BPOF4_RS13985	COG1309	transcriptional regulator
BPOF4_RS13990	COG1834	amidinotransferase
BPOF4_RS14000	COG0523	cobalamin synthesis protein
BPOF4_RS14030	COG1555	photosystem II stabilization
BPOF4_RS14030	COG3568	Endonuclease Exonuclease Phosphatase
BPOF4_RS14035	COG2201	protein-glutamate methylesterase activity
BPOF4_RS14040	COG0835	chemotaxis
BPOF4_RS14045	COG0643	Histidine kinase
BPOF4_RS14045	COG2198	Histidine kinase
BPOF4_RS14050	COG5001	Diguanylate cyclase
BPOF4_RS14050	COG3300	MHYT domain
BPOF4_RS14065	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BPOF4_RS14070	COG3639	organic phosphonate transmembrane transporter activity
BPOF4_RS14075	COG3639	organic phosphonate transmembrane transporter activity
BPOF4_RS14085	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BPOF4_RS14090	COG2153	protein acetylation
BPOF4_RS14110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BPOF4_RS14115	COG3829	transcription factor binding
BPOF4_RS14120	COG0506	proline dehydrogenase activity
BPOF4_RS14130	COG0704	Plays a role in the regulation of phosphate uptake
BPOF4_RS14135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BPOF4_RS14140	COG0581	inorganic phosphate transmembrane transporter activity
BPOF4_RS14145	COG0573	inorganic phosphate transmembrane transporter activity
BPOF4_RS14150	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BPOF4_RS14155	COG0840	transmembrane signaling receptor activity
BPOF4_RS14160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BPOF4_RS14165	COG1607	acyl-coa hydrolase
BPOF4_RS14175	COG2239	Acts as a magnesium transporter
BPOF4_RS14190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BPOF4_RS14195	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BPOF4_RS14200	COG0640	Transcriptional regulator
BPOF4_RS14205	COG0640	Transcriptional regulator
BPOF4_RS14220	COG1234	tRNA 3'-trailer cleavage
BPOF4_RS14225	COG1228	amidohydrolase
BPOF4_RS14235	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BPOF4_RS14240	COG2868	ribosomal protein
BPOF4_RS14245	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BPOF4_RS14255	COG1994	Peptidase M50
BPOF4_RS14260	COG0739	heme binding
BPOF4_RS14265	COG0746	molybdenum cofactor guanylyltransferase activity
BPOF4_RS14270	COG0667	Aldo Keto reductase
BPOF4_RS14275	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BPOF4_RS14280	COG0314	molybdopterin synthase activity
BPOF4_RS14285	COG1763	Mo-molybdopterin cofactor biosynthetic process
BPOF4_RS14290	COG0303	'Molybdopterin
BPOF4_RS14295	COG0521	Mo-molybdopterin cofactor biosynthetic process
BPOF4_RS14300	COG0315	cyclic pyranopterin monophosphate synthase activity
BPOF4_RS14305	COG0693	protein deglycase activity
BPOF4_RS14310	COG2894	cell division
BPOF4_RS14315	COG0850	regulation of cytokinetic process
BPOF4_RS14320	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BPOF4_RS14325	COG1792	Involved in formation and maintenance of cell shape
BPOF4_RS14330	COG1077	Cell shape determining protein MreB Mrl
BPOF4_RS14335	COG2003	Belongs to the UPF0758 family
BPOF4_RS14340	COG0424	maF-like protein
BPOF4_RS14365	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BPOF4_RS14375	COG1459	type II secretion system
BPOF4_RS14385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BPOF4_RS14400	COG0285	dihydrofolate synthase activity
BPOF4_RS14405	COG0525	valine-tRNA ligase activity
BPOF4_RS14425	COG1388	LysM domain
BPOF4_RS14425	COG1388	LysM domain
BPOF4_RS14430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BPOF4_RS14435	COG0113	porphobilinogen synthase activity
BPOF4_RS14440	COG1587	Uroporphyrinogen-III synthase
BPOF4_RS14445	COG0181	hydroxymethylbilane synthase activity
BPOF4_RS14450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BPOF4_RS14455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BPOF4_RS14465	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BPOF4_RS14470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BPOF4_RS14475	COG1067	ATP-dependent peptidase activity
BPOF4_RS14475	COG0470	DNA polymerase III
BPOF4_RS14480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BPOF4_RS14485	COG0544	peptidyl-prolyl cis-trans isomerase activity
BPOF4_RS14490	COG0457	Tetratricopeptide repeat
BPOF4_RS14490	COG1477	protein flavinylation
BPOF4_RS14495	COG0840	transmembrane signaling receptor activity
BPOF4_RS14500	COG0066	3-isopropylmalate dehydratase activity
BPOF4_RS14505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BPOF4_RS14510	COG0473	3-isopropylmalate dehydrogenase activity
BPOF4_RS14515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BPOF4_RS14520	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BPOF4_RS14525	COG0440	acetolactate synthase activity
BPOF4_RS14530	COG0028	Belongs to the TPP enzyme family
BPOF4_RS14535	COG0129	dihydroxy-acid dehydratase activity
BPOF4_RS14560	COG0622	Phosphoesterase
BPOF4_RS14565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BPOF4_RS14570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BPOF4_RS14575	COG5401	PFAM Sporulation and spore germination
BPOF4_RS14585	COG1846	Transcriptional regulator
BPOF4_RS14590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BPOF4_RS14595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BPOF4_RS14600	COG3711	transcriptional antiterminator
BPOF4_RS14605	COG2197	response regulator
BPOF4_RS14610	COG0824	Thioesterase
BPOF4_RS14615	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BPOF4_RS14620	COG1053	succinate dehydrogenase
BPOF4_RS14625	COG2009	succinate dehydrogenase
BPOF4_RS14630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BPOF4_RS14635	COG1719	4-vinyl reductase, 4VR
BPOF4_RS14640	COG0527	aspartate kinase activity
BPOF4_RS14645	COG0322	excinuclease ABC activity
BPOF4_RS14650	COG3118	belongs to the thioredoxin family
BPOF4_RS14655	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BPOF4_RS14660	COG2086	electron transfer activity
BPOF4_RS14665	COG1024	Enoyl-CoA hydratase
BPOF4_RS14670	COG1309	transcriptional regulator
BPOF4_RS14675	COG0318	PFAM AMP-dependent synthetase and ligase
BPOF4_RS14680	COG0318	PFAM AMP-dependent synthetase and ligase
BPOF4_RS14685	COG3766	membrane
BPOF4_RS14690	COG1193	negative regulation of DNA recombination
BPOF4_RS14695	COG1796	DNA polymerase
BPOF4_RS14695	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BPOF4_RS14715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BPOF4_RS14715	COG0072	phenylalanine-tRNA ligase activity
BPOF4_RS14720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BPOF4_RS14725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BPOF4_RS14735	COG1363	Peptidase, m42
BPOF4_RS14755	COG3326	Membrane
BPOF4_RS14760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BPOF4_RS14765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BPOF4_RS14770	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BPOF4_RS14775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BPOF4_RS14785	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BPOF4_RS14790	COG1484	DNA-dependent DNA replication
BPOF4_RS14795	COG3611	Membrane attachment protein
BPOF4_RS14800	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BPOF4_RS14810	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BPOF4_RS14815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BPOF4_RS14820	COG0237	dephospho-CoA kinase activity
BPOF4_RS14825	COG1971	Probably functions as a manganese efflux pump
BPOF4_RS14835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BPOF4_RS14835	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BPOF4_RS14840	COG0330	HflC and HflK could
BPOF4_RS14845	COG0330	HflC and HflK could
BPOF4_RS14850	COG5002	protein histidine kinase activity
BPOF4_RS14855	COG0745	RESPONSE REGULATOR receiver
BPOF4_RS14860	COG0039	L-malate dehydrogenase activity
BPOF4_RS14865	COG0538	isocitrate dehydrogenase activity
BPOF4_RS14870	COG0372	Belongs to the citrate synthase family
BPOF4_RS14875	COG2707	UPF0756 membrane protein
BPOF4_RS14880	COG3030	protein affecting phage T7 exclusion by the F plasmid
BPOF4_RS14890	COG0205	6-phosphofructokinase activity
BPOF4_RS14895	COG0825	malonyl-CoA metabolic process
BPOF4_RS14900	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BPOF4_RS14905	COG2186	Transcriptional regulator
BPOF4_RS14910	COG0281	malic enzyme
BPOF4_RS14915	COG0587	DNA-directed DNA polymerase activity
BPOF4_RS14935	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BPOF4_RS14945	COG4109	DRTGG domain
BPOF4_RS14955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BPOF4_RS14960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BPOF4_RS14970	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS14975	COG0165	Argininosuccinate lyase
BPOF4_RS14980	COG0137	argininosuccinate synthase activity
BPOF4_RS14990	COG2217	Heavy metal translocating P-type atpase
BPOF4_RS15000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BPOF4_RS15005	COG0827	DNA restriction-modification system
BPOF4_RS15010	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BPOF4_RS15015	COG3874	Sporulation protein YtfJ
BPOF4_RS15025	COG1714	RDD family
BPOF4_RS15030	COG0616	signal peptide processing
BPOF4_RS15035	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BPOF4_RS15040	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BPOF4_RS15045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BPOF4_RS15055	COG0301	tRNA thio-modification
BPOF4_RS15060	COG1104	cysteine desulfurase activity
BPOF4_RS15065	COG1114	Component of the transport system for branched-chain amino acids
BPOF4_RS15070	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BPOF4_RS15075	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BPOF4_RS15080	COG1309	transcriptional regulator
BPOF4_RS15085	COG1956	GAF domain-containing protein
BPOF4_RS15090	COG2203	Gaf domain
BPOF4_RS15090	COG2199	diguanylate cyclase activity
BPOF4_RS15095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BPOF4_RS15120	COG4916	TIR domain
BPOF4_RS15180	COG1484	DNA-dependent DNA replication
BPOF4_RS15195	COG4584	PFAM Integrase catalytic
BPOF4_RS15195	COG2390	Transcriptional regulator
BPOF4_RS15200	COG1484	DNA-dependent DNA replication
BPOF4_RS15225	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BPOF4_RS15235	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BPOF4_RS15280	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BPOF4_RS15285	COG4499	WXG100 protein secretion system (Wss), protein YukC
BPOF4_RS15285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BPOF4_RS15290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BPOF4_RS15295	COG0454	-acetyltransferase
BPOF4_RS15300	COG0517	IMP dehydrogenase activity
BPOF4_RS15305	COG0123	including yeast histone deacetylase and acetoin utilization protein
BPOF4_RS15310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BPOF4_RS15320	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BPOF4_RS15325	COG1609	Transcriptional regulator
BPOF4_RS15330	COG1605	Chorismate mutase
BPOF4_RS15330	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BPOF4_RS15335	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS15340	COG4980	gas vesicle protein
BPOF4_RS15350	COG2309	aminopeptidase activity
BPOF4_RS15355	COG1063	alcohol dehydrogenase
BPOF4_RS15365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BPOF4_RS15375	COG1674	ftsk spoiiie
BPOF4_RS15380	COG4848	Belongs to the UPF0354 family
BPOF4_RS15385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BPOF4_RS15400	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BPOF4_RS15405	COG1363	Peptidase, m42
BPOF4_RS15415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BPOF4_RS15430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BPOF4_RS15465	COG2909	trisaccharide binding
BPOF4_RS15475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BPOF4_RS15485	COG0510	thiamine kinase activity
BPOF4_RS15490	COG0788	formyltetrahydrofolate deformylase activity
BPOF4_RS15505	COG1346	cytolysis
BPOF4_RS15510	COG1380	Effector of murein hydrolase LrgA
BPOF4_RS15520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BPOF4_RS15525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BPOF4_RS15530	COG1349	DNA-binding transcription factor activity
BPOF4_RS15535	COG1187	pseudouridine synthase activity
BPOF4_RS15545	COG0772	Belongs to the SEDS family
BPOF4_RS15550	COG0772	Belongs to the SEDS family
BPOF4_RS15555	COG2244	polysaccharide biosynthetic process
BPOF4_RS15560	COG2081	HI0933 family
BPOF4_RS15565	COG0495	leucyl-tRNA aminoacylation
BPOF4_RS15570	COG2814	Major facilitator Superfamily
BPOF4_RS15575	COG1242	4 iron, 4 sulfur cluster binding
BPOF4_RS15580	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BPOF4_RS15585	COG0288	reversible hydration of carbon dioxide
BPOF4_RS15590	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS15600	COG2267	carboxylic ester hydrolase activity
BPOF4_RS15605	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BPOF4_RS15610	COG0671	phosphoesterase, PA-phosphatase related
BPOF4_RS15615	COG0438	transferase activity, transferring glycosyl groups
BPOF4_RS15625	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BPOF4_RS15630	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BPOF4_RS15640	COG1506	peptidase
BPOF4_RS15645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BPOF4_RS15650	COG1116	anion transmembrane transporter activity
BPOF4_RS15655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BPOF4_RS15660	COG0494	nUDIX hydrolase
BPOF4_RS15665	COG2814	Major facilitator Superfamily
BPOF4_RS15675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BPOF4_RS15680	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BPOF4_RS15685	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BPOF4_RS15690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BPOF4_RS15700	COG1523	belongs to the glycosyl hydrolase 13 family
BPOF4_RS15705	COG3237	CsbD-like
BPOF4_RS15710	COG0488	(ABC) transporter
BPOF4_RS15720	COG1428	Deoxynucleoside kinase
BPOF4_RS15725	COG1428	Deoxynucleoside kinase
BPOF4_RS15735	COG1231	oxidoreductase activity
BPOF4_RS15760	COG2197	response regulator
BPOF4_RS15765	COG2203	Gaf domain
BPOF4_RS15765	COG4585	Histidine kinase
BPOF4_RS15775	COG2223	nitrite transmembrane transporter activity
BPOF4_RS15785	COG1131	(ABC) transporter
BPOF4_RS15805	COG0395	ABC-type sugar transport system, permease component
BPOF4_RS15835	COG3546	catalase activity
BPOF4_RS15840	COG1609	Transcriptional regulator
BPOF4_RS15845	COG4876	unkown
BPOF4_RS15850	COG0517	IMP dehydrogenase activity
BPOF4_RS15985	COG4974	Belongs to the 'phage' integrase family
BPOF4_RS15995	COG1994	Peptidase M50
BPOF4_RS16010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BPOF4_RS16020	COG0166	Belongs to the GPI family
BPOF4_RS16025	COG1979	alcohol dehydrogenase
BPOF4_RS16030	COG2155	Conserved Protein
BPOF4_RS16035	COG1098	S1 RNA binding domain
BPOF4_RS16045	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BPOF4_RS16060	COG0436	Aminotransferase
BPOF4_RS16065	COG1522	sequence-specific DNA binding
BPOF4_RS16070	COG1335	isochorismatase
BPOF4_RS16075	COG0778	Nitroreductase
BPOF4_RS16080	COG0366	Alpha amylase catalytic
BPOF4_RS16085	COG1854	S-ribosylhomocysteine lyase activity
BPOF4_RS16100	COG1295	ribonuclease BN
BPOF4_RS16105	COG0776	regulation of translation
BPOF4_RS16110	COG1714	RDD family
BPOF4_RS16115	COG1268	BioY protein
BPOF4_RS16120	COG2056	Na+-H+ antiporter family
BPOF4_RS16125	COG1378	Sugar-specific transcriptional regulator TrmB
BPOF4_RS16130	COG2814	Major facilitator Superfamily
BPOF4_RS16140	COG0288	reversible hydration of carbon dioxide
BPOF4_RS16150	COG5609	conserved protein (DUF2294)
BPOF4_RS16155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BPOF4_RS16170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BPOF4_RS16175	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BPOF4_RS16180	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BPOF4_RS16185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BPOF4_RS16190	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BPOF4_RS16200	COG3584	3D domain protein
BPOF4_RS16205	COG0840	transmembrane signaling receptor activity
BPOF4_RS16210	COG1744	ABC transporter substrate-binding protein PnrA-like
BPOF4_RS16220	COG2323	membrane
BPOF4_RS16230	COG1252	NADH dehydrogenase
BPOF4_RS16235	COG0492	ferredoxin-NADP+ reductase activity
BPOF4_RS16240	COG0316	Belongs to the HesB IscA family
BPOF4_RS16250	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BPOF4_RS16255	COG0039	L-malate dehydrogenase activity
BPOF4_RS16260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BPOF4_RS16270	COG4844	belongs to the
BPOF4_RS16275	COG1252	NADH dehydrogenase
BPOF4_RS16280	COG4837	Protein of unknown function (DUF1462)
BPOF4_RS16285	COG1028	Short-chain dehydrogenase reductase Sdr
BPOF4_RS16290	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BPOF4_RS16300	COG0083	homoserine kinase activity
BPOF4_RS16305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BPOF4_RS16310	COG0460	homoserine dehydrogenase
BPOF4_RS16315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BPOF4_RS16320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BPOF4_RS16325	COG0647	UMP catabolic process
BPOF4_RS16335	COG2445	Protein of unknown function DUF86
BPOF4_RS16340	COG1494	fructose-1,6-bisphosphatase
BPOF4_RS16355	COG4470	Protein conserved in bacteria
BPOF4_RS16380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BPOF4_RS16385	COG0739	heme binding
BPOF4_RS16390	COG0733	neurotransmitter:sodium symporter activity
BPOF4_RS16395	COG1757	Na H antiporter
BPOF4_RS16405	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BPOF4_RS16410	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BPOF4_RS16420	COG3377	Domain of unknown function (DUF1805)
BPOF4_RS16425	COG0737	Belongs to the 5'-nucleotidase family
BPOF4_RS16430	COG0730	response to heat
BPOF4_RS16435	COG1801	Protein of unknown function DUF72
BPOF4_RS16440	COG0719	Fe-S assembly protein
BPOF4_RS16445	COG0822	iron-sulfur transferase activity
BPOF4_RS16450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BPOF4_RS16455	COG0719	Fe-S assembly protein
BPOF4_RS16460	COG0396	ATPase activity
BPOF4_RS16465	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BPOF4_RS16470	COG1464	Belongs to the NlpA lipoprotein family
BPOF4_RS16475	COG2011	ABC-type metal ion transport system permease component
BPOF4_RS16480	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BPOF4_RS16495	COG0509	glycine decarboxylation via glycine cleavage system
BPOF4_RS16500	COG1393	Belongs to the ArsC family
BPOF4_RS16505	COG1960	acyl-CoA dehydrogenase activity
BPOF4_RS16510	COG0183	Belongs to the thiolase family
BPOF4_RS16515	COG1024	Enoyl-CoA hydratase
BPOF4_RS16515	COG1250	3-hydroxyacyl-CoA dehydrogenase
BPOF4_RS16525	COG5577	PFAM Coat F domain
BPOF4_RS16535	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BPOF4_RS16540	COG3711	transcriptional antiterminator
BPOF4_RS16555	COG1131	(ABC) transporter
BPOF4_RS16585	COG1301	dicarboxylic acid transport
BPOF4_RS16590	COG1063	alcohol dehydrogenase
BPOF4_RS16595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BPOF4_RS16605	COG1316	TRANSCRIPTIONal
BPOF4_RS16630	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BPOF4_RS16635	COG0557	exoribonuclease II activity
BPOF4_RS16640	COG1647	Serine aminopeptidase, S33
BPOF4_RS16650	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BPOF4_RS16655	COG0148	phosphopyruvate hydratase activity
BPOF4_RS16660	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BPOF4_RS16670	COG0126	phosphoglycerate kinase activity
BPOF4_RS16675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BPOF4_RS16690	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BPOF4_RS16695	COG0740	serine-type endopeptidase activity
BPOF4_RS16700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BPOF4_RS16705	COG1481	regulation of sporulation
BPOF4_RS16710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BPOF4_RS16715	COG1660	Displays ATPase and GTPase activities
BPOF4_RS16720	COG1051	belongs to the nudix hydrolase family
BPOF4_RS16725	COG0492	ferredoxin-NADP+ reductase activity
BPOF4_RS16730	COG0457	Tetratricopeptide repeat
BPOF4_RS16740	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BPOF4_RS16740	COG0140	phosphoribosyl-ATP diphosphatase activity
BPOF4_RS16745	COG0107	imidazoleglycerol-phosphate synthase activity
BPOF4_RS16750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BPOF4_RS16755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BPOF4_RS16760	COG0131	Imidazoleglycerol-phosphate dehydratase
BPOF4_RS16765	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BPOF4_RS16770	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BPOF4_RS16775	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BPOF4_RS16780	COG0110	maltose O-acetyltransferase activity
BPOF4_RS16785	COG0546	phosphoglycolate phosphatase activity
BPOF4_RS16790	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BPOF4_RS16795	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BPOF4_RS16800	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BPOF4_RS16805	COG1950	PFAM Membrane protein of
BPOF4_RS16810	COG1983	PspC domain protein
BPOF4_RS16815	COG3595	metallopeptidase activity
BPOF4_RS16820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BPOF4_RS16825	COG0556	nucleotide-excision repair
BPOF4_RS16835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BPOF4_RS16840	COG0793	Belongs to the peptidase S41A family
BPOF4_RS16840	COG3409	Peptidoglycan-binding domain 1 protein
BPOF4_RS16845	COG2223	nitrite transmembrane transporter activity
BPOF4_RS16850	COG0243	molybdopterin cofactor binding
BPOF4_RS16855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BPOF4_RS16860	COG0739	heme binding
BPOF4_RS16865	COG2177	Part of the ABC transporter FtsEX involved in
BPOF4_RS16870	COG2884	Cell division ATP-binding protein ftsE
BPOF4_RS16875	COG2010	Cytochrome c
BPOF4_RS16880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BPOF4_RS16890	COG0653	protein targeting
BPOF4_RS16895	COG3290	protein histidine kinase activity
BPOF4_RS16900	COG4565	transcriptional regulatory protein
BPOF4_RS16905	COG0471	metal ion transport
BPOF4_RS16915	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BPOF4_RS16920	COG1278	Cold shock
BPOF4_RS16935	COG1516	flagellar protein fliS
BPOF4_RS16945	COG2146	nitrite reductase [NAD(P)H] activity
BPOF4_RS16950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BPOF4_RS16955	COG2116	formate transmembrane transporter activity
BPOF4_RS16960	COG1587	Uroporphyrinogen-III synthase
BPOF4_RS16960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BPOF4_RS16965	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BPOF4_RS16995	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BPOF4_RS17005	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BPOF4_RS17010	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BPOF4_RS17030	COG1256	bacterial-type flagellum assembly
BPOF4_RS17030	COG4786	Flagellar basal body rod
BPOF4_RS17040	COG2747	anti-sigma28 factor FlgM
BPOF4_RS17050	COG1040	competence protein
BPOF4_RS17055	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BPOF4_RS17060	COG1307	EDD domain protein, DegV family
BPOF4_RS17075	COG1739	Uncharacterized protein family UPF0029
BPOF4_RS17080	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BPOF4_RS17085	COG1522	sequence-specific DNA binding
BPOF4_RS17090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BPOF4_RS17095	COG0601	transmembrane transport
BPOF4_RS17105	COG4608	Belongs to the ABC transporter superfamily
BPOF4_RS17110	COG0444	Belongs to the ABC transporter superfamily
BPOF4_RS17115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BPOF4_RS17120	COG0601	transmembrane transport
BPOF4_RS17125	COG0747	negative chemotaxis
BPOF4_RS17130	COG4608	Belongs to the ABC transporter superfamily
BPOF4_RS17135	COG0444	Belongs to the ABC transporter superfamily
BPOF4_RS17140	COG1316	TRANSCRIPTIONal
BPOF4_RS17145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BPOF4_RS17160	COG2244	polysaccharide biosynthetic process
BPOF4_RS17165	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BPOF4_RS17170	COG0653	protein targeting
BPOF4_RS17185	COG4193	domain, Protein
BPOF4_RS17185	COG5263	repeat protein
BPOF4_RS17190	COG1361	Conserved repeat domain
BPOF4_RS17200	COG1404	Belongs to the peptidase S8 family
BPOF4_RS17215	COG1696	Membrane protein involved in D-alanine export
BPOF4_RS17220	COG0010	Belongs to the arginase family
BPOF4_RS17235	COG0840	transmembrane signaling receptor activity
BPOF4_RS17240	COG0577	efflux transmembrane transporter activity
BPOF4_RS17245	COG1136	(ABC) transporter
BPOF4_RS17250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BPOF4_RS17260	COG1404	Belongs to the peptidase S8 family
BPOF4_RS17270	COG2340	Cysteine-rich secretory protein family
BPOF4_RS17295	COG0737	Belongs to the 5'-nucleotidase family
BPOF4_RS17305	COG0737	Belongs to the 5'-nucleotidase family
BPOF4_RS17310	COG3266	domain, Protein
BPOF4_RS17310	COG2911	Protein conserved in bacteria
BPOF4_RS17310	COG1361	Conserved repeat domain
BPOF4_RS17315	COG1388	LysM domain
BPOF4_RS17315	COG0791	NLP P60 protein
BPOF4_RS17320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BPOF4_RS17405	COG1361	Conserved repeat domain
BPOF4_RS17415	COG2801	Transposase and inactivated derivatives
BPOF4_RS17425	COG0791	NLP P60 protein
BPOF4_RS17425	COG1388	LysM domain
BPOF4_RS17435	COG4124	Belongs to the glycosyl hydrolase 26 family
BPOF4_RS17440	COG1649	PFAM Uncharacterised BCR, COG1649
BPOF4_RS17440	COG0726	polysaccharide deacetylase
BPOF4_RS17455	COG0791	NLP P60 protein
BPOF4_RS17455	COG1388	LysM domain
BPOF4_RS17465	COG0489	protein tyrosine kinase activity
BPOF4_RS17470	COG3944	biosynthesis protein
BPOF4_RS17500	COG3177	Filamentation induced by cAMP protein fic
BPOF4_RS17505	COG0653	protein targeting
BPOF4_RS17525	COG0367	asparagine synthase
BPOF4_RS17530	COG0745	RESPONSE REGULATOR receiver
BPOF4_RS17535	COG5002	protein histidine kinase activity
BPOF4_RS17555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BPOF4_RS17615	COG0531	amino acid
BPOF4_RS17650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BPOF4_RS17660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BPOF4_RS17665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BPOF4_RS17670	COG1609	Transcriptional regulator
BPOF4_RS17800	COG4372	Transposase
BPOF4_RS17825	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BPOF4_RS17840	COG2244	polysaccharide biosynthetic process
BPOF4_RS17850	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BPOF4_RS17855	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BPOF4_RS17865	COG1045	serine acetyltransferase
BPOF4_RS17870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BPOF4_RS17875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BPOF4_RS17885	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BPOF4_RS17900	COG4464	protein tyrosine phosphatase activity
BPOF4_RS17925	COG0791	NLP P60 protein
BPOF4_RS17930	COG2843	Capsule synthesis protein
BPOF4_RS17940	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BPOF4_RS17950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BPOF4_RS17995	COG1316	TRANSCRIPTIONal
BPOF4_RS18020	COG4786	Flagellar basal body rod
BPOF4_RS18025	COG4786	Flagellar basal body rod
BPOF4_RS18030	COG1077	Cell shape determining protein MreB Mrl
BPOF4_RS18035	COG1609	Transcriptional regulator
BPOF4_RS18040	COG2176	DNA-directed DNA polymerase activity
BPOF4_RS18045	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BPOF4_RS18050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BPOF4_RS18070	COG0739	heme binding
BPOF4_RS18080	COG2385	sporulation resulting in formation of a cellular spore
BPOF4_RS18090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BPOF4_RS18100	COG4836	Membrane
BPOF4_RS18105	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BPOF4_RS18110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BPOF4_RS18115	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BPOF4_RS18120	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BPOF4_RS18125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BPOF4_RS18130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BPOF4_RS18135	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BPOF4_RS18140	COG0356	it plays a direct role in the translocation of protons across the membrane
BPOF4_RS18160	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BPOF4_RS18165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BPOF4_RS18170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BPOF4_RS18175	COG4475	Protein of unknown function (DUF436)
BPOF4_RS18180	COG0698	ribose 5-phosphate isomerase
BPOF4_RS18185	COG0840	transmembrane signaling receptor activity
BPOF4_RS18190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BPOF4_RS18195	COG1971	Probably functions as a manganese efflux pump
BPOF4_RS18200	COG0009	L-threonylcarbamoyladenylate synthase
BPOF4_RS18220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BPOF4_RS18225	COG0446	pyridine nucleotide-disulphide oxidoreductase
BPOF4_RS18230	COG0840	transmembrane signaling receptor activity
BPOF4_RS18240	COG1435	thymidine kinase activity
BPOF4_RS18245	COG0254	rRNA binding
BPOF4_RS18250	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BPOF4_RS18255	COG1494	fructose-1,6-bisphosphatase
BPOF4_RS18260	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BPOF4_RS18265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BPOF4_RS18270	COG0191	fructose-bisphosphate aldolase activity
BPOF4_RS18275	COG2204	response regulator
BPOF4_RS18285	COG0504	CTP synthase activity
BPOF4_RS18290	COG3343	RNA polymerase activity
BPOF4_RS18295	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BPOF4_RS18295	COG1703	isobutyryl-CoA mutase activity
BPOF4_RS18295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BPOF4_RS18305	COG1960	acyl-CoA dehydrogenase activity
BPOF4_RS18310	COG1960	acyl-CoA dehydrogenase activity
BPOF4_RS18315	COG1250	3-hydroxyacyl-CoA dehydrogenase
BPOF4_RS18320	COG0183	Belongs to the thiolase family
BPOF4_RS18325	COG2181	nitrate reductase activity
BPOF4_RS18325	COG0247	lactate metabolic process
BPOF4_RS18330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BPOF4_RS18340	COG0569	domain protein
BPOF4_RS18345	COG2323	membrane
BPOF4_RS18360	COG2839	Protein conserved in bacteria
BPOF4_RS18365	COG0018	arginyl-trna synthetase
BPOF4_RS18375	COG0010	Belongs to the arginase family
BPOF4_RS18380	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BPOF4_RS18385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BPOF4_RS18400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BPOF4_RS18405	COG3829	transcription factor binding
BPOF4_RS18410	COG3871	stress protein (general stress protein 26)
BPOF4_RS18430	COG3465	dGTPase activity
BPOF4_RS18435	COG1078	dGTPase activity
BPOF4_RS18440	COG1301	dicarboxylic acid transport
BPOF4_RS18445	COG4844	belongs to the
BPOF4_RS18450	COG0095	Lipoate-protein ligase
BPOF4_RS18460	COG0280	phosphate acetyltransferase
BPOF4_RS18465	COG1024	Enoyl-CoA hydratase
BPOF4_RS18470	COG3253	May function as heme-dependent peroxidase
BPOF4_RS18475	COG5001	Diguanylate cyclase
BPOF4_RS18475	COG3300	MHYT domain
BPOF4_RS18480	COG1522	sequence-specific DNA binding
BPOF4_RS18490	COG3773	Cell wall hydrolase
BPOF4_RS18505	COG2363	Small membrane protein
BPOF4_RS18510	COG0456	acetyltransferase
BPOF4_RS18525	COG0789	Transcriptional regulator
BPOF4_RS18530	COG2176	DNA-directed DNA polymerase activity
BPOF4_RS18540	COG0004	ammonium transporteR
BPOF4_RS18545	COG5577	PFAM Coat F domain
BPOF4_RS18555	COG0656	L-ascorbic acid biosynthetic process
BPOF4_RS18560	COG4149	molybdate abc transporter
BPOF4_RS18570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BPOF4_RS18575	COG1404	Belongs to the peptidase S8 family
BPOF4_RS18580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BPOF4_RS18580	COG1263	PTS System
BPOF4_RS18585	COG4221	oxidoreductase activity
BPOF4_RS18590	COG3314	Sporulation integral membrane protein YlbJ
BPOF4_RS18595	COG1621	beta-fructofuranosidase activity
BPOF4_RS18605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BPOF4_RS18610	COG0351	phosphomethylpyrimidine kinase
BPOF4_RS18615	COG2962	Rard protein
BPOF4_RS18630	COG2084	Dehydrogenase
BPOF4_RS18635	COG4607	ABC-type enterochelin transport system periplasmic component
BPOF4_RS18640	COG4604	ABC transporter, ATP-binding protein
BPOF4_RS18645	COG4605	iron ion homeostasis
BPOF4_RS18650	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BPOF4_RS18655	COG0513	Belongs to the DEAD box helicase family
BPOF4_RS18660	COG0366	Alpha amylase catalytic
BPOF4_RS18665	COG2190	(PTS) system
BPOF4_RS18665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BPOF4_RS18665	COG1263	PTS System
BPOF4_RS18680	COG2124	cytochrome p450
BPOF4_RS18685	COG3243	poly(R)-hydroxyalkanoic acid synthase
BPOF4_RS18695	COG2124	cytochrome p450
BPOF4_RS18700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BPOF4_RS18710	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BPOF4_RS18715	COG0723	plastoquinol--plastocyanin reductase activity
BPOF4_RS18715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BPOF4_RS18720	COG4895	conserved protein (DUF2196)
BPOF4_RS18725	COG0346	lactoylglutathione lyase activity
BPOF4_RS18730	COG0840	transmembrane signaling receptor activity
BPOF4_RS18735	COG0551	DNA topoisomerase type I activity
BPOF4_RS18735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BPOF4_RS18740	COG2076	Multidrug Resistance protein
BPOF4_RS18745	COG2076	Multidrug Resistance protein
BPOF4_RS18765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BPOF4_RS18775	COG1012	belongs to the aldehyde dehydrogenase family
BPOF4_RS18800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BPOF4_RS18805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BPOF4_RS18810	COG1454	alcohol dehydrogenase
BPOF4_RS18835	COG0747	negative chemotaxis
BPOF4_RS18840	COG0753	catalase activity
BPOF4_RS18930	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BPOF4_RS18935	COG5002	protein histidine kinase activity
BPOF4_RS18940	COG0693	protein deglycase activity
BPOF4_RS18950	COG2323	membrane
BPOF4_RS18955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BPOF4_RS18960	COG3314	Sporulation integral membrane protein YlbJ
BPOF4_RS18975	COG0579	oxidoreductase
BPOF4_RS18980	COG4682	membrane
BPOF4_RS18985	COG0450	alkyl hydroperoxide reductase
BPOF4_RS18990	COG3634	alkyl hydroperoxide reductase activity
BPOF4_RS19000	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BPOF4_RS19025	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BPOF4_RS19035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BPOF4_RS19040	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BPOF4_RS19045	COG4853	Protein conserved in bacteria
BPOF4_RS19055	COG5002	protein histidine kinase activity
BPOF4_RS19060	COG0745	RESPONSE REGULATOR receiver
BPOF4_RS19090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BPOF4_RS19095	COG0305	Participates in initiation and elongation during chromosome replication
BPOF4_RS19100	COG0359	binds to the 23S rRNA
BPOF4_RS19105	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BPOF4_RS19110	COG4241	membrane
BPOF4_RS19115	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BPOF4_RS19120	COG0629	single-stranded DNA binding
BPOF4_RS19125	COG0360	Binds together with S18 to 16S ribosomal RNA
BPOF4_RS19130	COG0012	GTP binding
BPOF4_RS19135	COG4481	Protein conserved in bacteria
BPOF4_RS19140	COG3949	Membrane
BPOF4_RS19155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BPOF4_RS19160	COG1475	DNA binding
BPOF4_RS19165	COG1192	Involved in chromosome partitioning
BPOF4_RS19170	COG1475	DNA binding
BPOF4_RS19175	COG0357	Ribosomal RNA small subunit methyltransferase G
BPOF4_RS19180	COG0445	tRNA wobble uridine modification
BPOF4_RS19185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BPOF4_RS19190	COG1847	R3H domain protein
BPOF4_RS19195	COG0706	membrane insertase activity
BPOF4_RS19200	COG0594	ribonuclease P activity
BPOF4_RS19205	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BPOF4_RS19235	COG0783	Belongs to the Dps family
BPOF4_RS19240	COG0840	transmembrane signaling receptor activity
BPOF4_RS19250	COG5444	nuclease activity
BPOF4_RS19260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BPOF4_RS19320	COG1793	dna ligase
BPOF4_RS19355	COG0629	single-stranded DNA binding
BPOF4_RS19370	COG4974	Belongs to the 'phage' integrase family
BPOF4_RS19375	COG4974	Belongs to the 'phage' integrase family
BPOF4_RS19380	COG4956	integral membrane protein (PIN domain superfamily)
BPOF4_RS19415	COG2217	Heavy metal translocating P-type atpase
BPOF4_RS19430	COG0717	Belongs to the dCTP deaminase family
BPOF4_RS19455	COG3344	reverse transcriptase
BPOF4_RS19460	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BPOF4_RS19460	COG0456	acetyltransferase
BPOF4_RS19470	COG4584	PFAM Integrase catalytic
BPOF4_RS19470	COG2390	Transcriptional regulator
BPOF4_RS19475	COG1484	DNA-dependent DNA replication
BPOF4_RS19490	COG3879	Bacterial protein of unknown function (DUF881)
BPOF4_RS19520	COG5002	protein histidine kinase activity
BPOF4_RS19525	COG0745	RESPONSE REGULATOR receiver
BPOF4_RS19540	COG3336	cytochrome c oxidase
BPOF4_RS19580	COG0398	Pfam SNARE associated Golgi protein
BPOF4_RS19605	COG1876	peptidase activity
BPOF4_RS19630	COG0860	N-Acetylmuramoyl-L-alanine amidase
BPOF4_RS19645	COG0367	asparagine synthase
BPOF4_RS19655	COG0785	Cytochrome C biogenesis protein
BPOF4_RS19660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BPOF4_RS19665	COG1333	cytochrome c biogenesis protein
BPOF4_RS19670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BPOF4_RS19675	COG5002	protein histidine kinase activity
BPOF4_RS19680	COG0745	RESPONSE REGULATOR receiver
BPOF4_RS19690	COG0803	Belongs to the bacterial solute-binding protein 9 family
BPOF4_RS19690	COG3443	Belongs to the bacterial solute-binding protein 9 family
BPOF4_RS19695	COG2132	Multicopper oxidase
BPOF4_RS19705	COG0803	Belongs to the bacterial solute-binding protein 9 family
BPOF4_RS19710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BPOF4_RS19715	COG1121	(ABC) transporter
BPOF4_RS19740	COG4974	Belongs to the 'phage' integrase family
BPOF4_RS19800	COG2274	protein secretion by the type I secretion system
BPOF4_RS19940	COG0561	phosphatase activity
BPOF4_RS19945	COG2364	Membrane
BPOF4_RS19950	COG1609	Transcriptional regulator
BPOF4_RS20015	COG2003	Belongs to the UPF0758 family
BPOF4_RS20020	COG0629	single-stranded DNA binding
BPOF4_RS20180	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BPOF4_RS20195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BPOF4_RS20380	COG1466	dna polymerase III delta subunit
BPOF4_RS20385	COG0592	DNA-directed DNA polymerase activity
BPOF4_RS20510	COG1051	belongs to the nudix hydrolase family
BPOF4_RS20525	COG1484	DNA-dependent DNA replication
BPOF4_RS20530	COG2390	Transcriptional regulator
BPOF4_RS20530	COG4584	PFAM Integrase catalytic
BPOF4_RS20565	COG1609	Transcriptional regulator
BPOF4_RS20570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BPOF4_RS20575	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BPOF4_RS20575	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BPOF4_RS20580	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BPOF4_RS20580	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BPOF4_RS20585	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BPOF4_RS20595	COG1012	belongs to the aldehyde dehydrogenase family
BPOF4_RS20600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BPOF4_RS20605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BPOF4_RS20640	COG0582	viral genome integration into host DNA
BPOF4_RS20645	COG3263	regulation of cellular component size
BPOF4_RS20660	COG0628	permease
BPOF4_RS20675	COG0704	Plays a role in the regulation of phosphate uptake
BPOF4_RS20700	COG1366	Belongs to the anti-sigma-factor antagonist family
BPOF4_RS20715	COG1609	Transcriptional regulator
BPOF4_RS20820	COG4974	Belongs to the 'phage' integrase family
BPOF4_RS20925	COG0433	COG0433 Predicted ATPase
BPOF4_RS20940	COG0791	NLP P60 protein
BPOF4_RS20940	COG0741	lytic transglycosylase activity
BPOF4_RS20950	COG2002	toxin-antitoxin pair type II binding
BPOF4_RS20980	COG0791	NLP P60 protein
BPOF4_RS20980	COG0741	lytic transglycosylase activity
BPOF4_RS21010	COG1131	(ABC) transporter
BPOF4_RS21060	COG3850	Histidine kinase
BPOF4_RS21060	COG5002	protein histidine kinase activity
BPOF4_RS21070	COG5444	nuclease activity
BPOF4_RS21075	COG3706	GGDEF domain
BPOF4_RS21090	COG3212	peptidase
BPOF4_RS21095	COG3290	protein histidine kinase activity
BPOF4_RS21115	COG4948	Mandelate Racemase Muconate Lactonizing
BPOF4_RS21130	COG0671	phosphoesterase, PA-phosphatase related
BPOF4_RS21135	COG0745	RESPONSE REGULATOR receiver
BPOF4_RS21155	COG4191	Histidine kinase
BPOF4_RS21175	COG1405	negative regulation of cell septum assembly
BPOF4_RS21175	COG3012	SEC-C Motif Domain Protein
BPOF4_RS21205	COG4191	Histidine kinase
BPOF4_RS21210	COG4191	Histidine kinase
BPOF4_RS21230	COG3190	flagellar
BPOF4_RS21235	COG0741	lytic transglycosylase activity
BPOF4_RS21285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BPOF4_RS21285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BPOF4_RS21290	COG2247	cell wall binding repeat
BPOF4_RS21290	COG0860	N-Acetylmuramoyl-L-alanine amidase
BPOF4_RS21300	COG1686	Belongs to the peptidase S11 family
BPOF4_RS21310	COG1404	Belongs to the peptidase S8 family
BPOF4_RS21315	COG0860	N-Acetylmuramoyl-L-alanine amidase
BPOF4_RS21325	COG2340	Cysteine-rich secretory protein family
BPOF4_RS21360	COG1196	nuclear chromosome segregation
BPOF4_RS21360	COG0741	lytic transglycosylase activity
BPOF4_RS21360	COG0739	heme binding
BPOF4_RS21370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BPOF4_RS21390	COG1361	Conserved repeat domain
BPOF4_RS21405	COG3583	domain protein
BPOF4_RS21405	COG3584	3D domain protein
BPOF4_RS21455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BPOF4_RS21585	COG3093	addiction module antidote protein HigA
BPOF4_RS21685	COG4969	Belongs to the N-Me-Phe pilin family
BPOF4_RS21885	COG4191	Histidine kinase
BPOF4_RS21890	COG5002	protein histidine kinase activity
BPOF4_RS22410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BPOF4_RS22410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BPOF4_RS22415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BPOF4_RS22415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BPOF4_RS22565	COG1366	Belongs to the anti-sigma-factor antagonist family
BPOF4_RS22575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BPOF4_RS22575	COG2207	Transcriptional regulator
BPOF4_RS22610	COG0813	purine-nucleoside phosphorylase activity
BPOF4_RS22630	COG0011	TIGRFAM Protein of
BPOF4_RS22710	COG2226	methyltransferase
BPOF4_RS22730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone