locus-tag	class	description
MLG_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MLG_RS00020	COG0592	DNA-directed DNA polymerase activity
MLG_RS00045	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MLG_RS00060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MLG_RS00065	COG0751	glycine-tRNA ligase activity
MLG_RS00070	COG0752	glycyl-tRNA synthetase alpha subunit
MLG_RS00075	COG0174	glutamine synthetase
MLG_RS00085	COG3852	Histidine kinase
MLG_RS00095	COG0602	queuosine metabolic process
MLG_RS00105	COG0459	protein refolding
MLG_RS00110	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MLG_RS00115	COG1324	tolerance protein
MLG_RS00120	COG4232	protein-disulfide reductase activity
MLG_RS00125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MLG_RS00130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MLG_RS00135	COG0511	ligase activity, forming carbon-carbon bonds
MLG_RS00140	COG0439	Biotin carboxylase
MLG_RS00150	COG0730	response to heat
MLG_RS00160	COG0617	tRNA 3'-terminal CCA addition
MLG_RS00170	COG0667	Aldo Keto reductase
MLG_RS00175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MLG_RS00180	COG2022	thiamine diphosphate biosynthetic process
MLG_RS00225	COG3501	Rhs element vgr protein
MLG_RS00275	COG3829	transcription factor binding
MLG_RS00310	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MLG_RS00325	COG1309	transcriptional regulator
MLG_RS00330	COG0604	alcohol dehydrogenase
MLG_RS00335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MLG_RS00340	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MLG_RS00350	COG2226	methyltransferase
MLG_RS00360	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MLG_RS00365	COG1166	arginine decarboxylase activity
MLG_RS00370	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MLG_RS00380	COG1714	RDD family
MLG_RS00385	COG0390	transport system, permease component
MLG_RS00390	COG3842	ATPase activity
MLG_RS00400	COG0004	ammonium transporteR
MLG_RS00410	COG2960	long-chain fatty acid transporting porin activity
MLG_RS00425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MLG_RS00435	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MLG_RS00440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MLG_RS00460	COG0633	Ferredoxin
MLG_RS00460	COG0543	2 iron, 2 sulfur cluster binding
MLG_RS00465	COG0477	Major facilitator Superfamily
MLG_RS00485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MLG_RS00510	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MLG_RS00510	COG0662	Cupin 2, conserved barrel domain protein
MLG_RS00535	COG2226	methyltransferase
MLG_RS00605	COG1132	(ABC) transporter
MLG_RS00615	COG0318	PFAM AMP-dependent synthetase and ligase
MLG_RS00640	COG1834	amidinotransferase
MLG_RS00650	COG1216	Glycosyl transferase, family 2
MLG_RS00655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MLG_RS00670	COG0438	transferase activity, transferring glycosyl groups
MLG_RS00675	COG0438	transferase activity, transferring glycosyl groups
MLG_RS00680	COG0367	asparagine synthase
MLG_RS00685	COG0438	transferase activity, transferring glycosyl groups
MLG_RS00710	COG3267	Type II secretory pathway component ExeA
MLG_RS00710	COG3409	Peptidoglycan-binding domain 1 protein
MLG_RS00720	COG0489	protein tyrosine kinase activity
MLG_RS00780	COG0643	Histidine kinase
MLG_RS00780	COG2198	Histidine kinase
MLG_RS00785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MLG_RS00800	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MLG_RS00810	COG3706	GGDEF domain
MLG_RS00815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MLG_RS00820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MLG_RS00825	COG0154	amidase activity
MLG_RS00830	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MLG_RS00835	COG1077	Cell shape determining protein MreB Mrl
MLG_RS00840	COG1792	Involved in formation and maintenance of cell shape
MLG_RS00850	COG0768	penicillin binding
MLG_RS00855	COG0772	Belongs to the SEDS family
MLG_RS00860	COG2951	lytic endotransglycosylase activity
MLG_RS00870	COG1686	Belongs to the peptidase S11 family
MLG_RS00880	COG2921	Belongs to the UPF0250 family
MLG_RS00885	COG0321	lipoyl(octanoyl) transferase activity
MLG_RS00895	COG0829	nickel cation binding
MLG_RS00900	COG0831	urea catabolic process
MLG_RS00905	COG0832	Belongs to the urease beta subunit family
MLG_RS00910	COG0804	urea catabolic process
MLG_RS00920	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MLG_RS00925	COG0830	nickel cation binding
MLG_RS00930	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MLG_RS00980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MLG_RS00990	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MLG_RS00995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MLG_RS01000	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MLG_RS01020	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MLG_RS01035	COG1309	transcriptional regulator
MLG_RS01050	COG1047	Peptidyl-prolyl cis-trans
MLG_RS01070	COG0437	4 iron, 4 sulfur cluster binding
MLG_RS01075	COG0243	molybdopterin cofactor binding
MLG_RS01090	COG4191	Histidine kinase
MLG_RS01100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MLG_RS01105	COG2967	ApaG domain
MLG_RS01110	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MLG_RS01120	COG1331	Highly conserved protein containing a thioredoxin domain
MLG_RS01125	COG1959	2 iron, 2 sulfur cluster binding
MLG_RS01135	COG0523	cobalamin synthesis protein
MLG_RS01155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MLG_RS01170	COG0069	glutamate synthase activity
MLG_RS01210	COG0823	Involved in the tonB-independent uptake of proteins
MLG_RS01230	COG0280	phosphate acetyltransferase
MLG_RS01230	COG0281	malic enzyme
MLG_RS01245	COG0492	ferredoxin-NADP+ reductase activity
MLG_RS01305	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MLG_RS01335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MLG_RS01345	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MLG_RS01350	COG0508	dehydrogenase complex catalyzes the overall conversion of
MLG_RS01355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MLG_RS01360	COG2890	protein-(glutamine-N5) methyltransferase activity
MLG_RS01370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MLG_RS01375	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MLG_RS01380	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MLG_RS01385	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MLG_RS01390	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MLG_RS01395	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MLG_RS01405	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MLG_RS01410	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MLG_RS01420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MLG_RS01425	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MLG_RS01430	COG0193	aminoacyl-tRNA hydrolase activity
MLG_RS01435	COG0012	GTP binding
MLG_RS01455	COG0166	Belongs to the GPI family
MLG_RS01465	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MLG_RS01470	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MLG_RS01475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MLG_RS01505	COG1612	heme a metabolic process
MLG_RS01510	COG0109	protoheme IX farnesyltransferase activity
MLG_RS01540	COG0277	FAD linked oxidase domain protein
MLG_RS01545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MLG_RS01565	COG0003	Pfam Anion-transporting ATPase
MLG_RS01575	COG1966	Carbon starvation protein
MLG_RS01580	COG0589	response to stress
MLG_RS01590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MLG_RS01595	COG3118	belongs to the thioredoxin family
MLG_RS01600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MLG_RS01605	COG0071	Belongs to the small heat shock protein (HSP20) family
MLG_RS01620	COG2217	Heavy metal translocating P-type atpase
MLG_RS01665	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MLG_RS01670	COG2885	chlorophyll binding
MLG_RS01680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MLG_RS01680	COG0425	Belongs to the sulfur carrier protein TusA family
MLG_RS01690	COG0616	signal peptide processing
MLG_RS01700	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MLG_RS01705	COG0123	including yeast histone deacetylase and acetoin utilization protein
MLG_RS01710	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MLG_RS01715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MLG_RS01715	COG2813	Specifically methylates the guanine in position
MLG_RS01720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MLG_RS01755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MLG_RS01760	COG0540	Belongs to the ATCase OTCase family
MLG_RS01765	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MLG_RS01770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MLG_RS01775	COG1678	Uncharacterized ACR, COG1678
MLG_RS01820	COG0840	transmembrane signaling receptor activity
MLG_RS01825	COG0643	Histidine kinase
MLG_RS01825	COG2198	Histidine kinase
MLG_RS01835	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MLG_RS01845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MLG_RS01845	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MLG_RS01860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MLG_RS01865	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MLG_RS01875	COG1011	Hydrolase
MLG_RS01880	COG0494	nUDIX hydrolase
MLG_RS01885	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MLG_RS01895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MLG_RS01900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MLG_RS01905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MLG_RS01905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MLG_RS01920	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MLG_RS01925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MLG_RS01930	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MLG_RS01945	COG4372	Transposase
MLG_RS01960	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MLG_RS01965	COG5265	(ABC) transporter
MLG_RS01970	COG5285	phytanoyl-CoA dioxygenase
MLG_RS01980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MLG_RS01985	COG1702	phosphate starvation-inducible protein PhoH
MLG_RS01990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MLG_RS01995	COG4535	Mg2 and Co2 transporter CorC
MLG_RS02000	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MLG_RS02010	COG0495	leucyl-tRNA aminoacylation
MLG_RS02020	COG1466	dna polymerase III delta subunit
MLG_RS02025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MLG_RS02030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MLG_RS02040	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MLG_RS02050	COG0424	maF-like protein
MLG_RS02070	COG0312	modulator of DNA gyrase
MLG_RS02075	COG0312	modulator of DNA gyrase
MLG_RS02095	COG2133	pyrroloquinoline quinone binding
MLG_RS02100	COG0129	dihydroxy-acid dehydratase activity
MLG_RS02105	COG2096	Adenosyltransferase
MLG_RS02130	COG1346	cytolysis
MLG_RS02135	COG1380	Effector of murein hydrolase LrgA
MLG_RS02145	COG0494	nUDIX hydrolase
MLG_RS02165	COG1981	membrane
MLG_RS02170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MLG_RS02180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MLG_RS02185	COG0316	Belongs to the HesB IscA family
MLG_RS02190	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MLG_RS02195	COG0739	heme binding
MLG_RS02200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MLG_RS02230	COG1362	aminopeptidase activity
MLG_RS02255	COG3243	poly(R)-hydroxyalkanoic acid synthase
MLG_RS02275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MLG_RS02295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MLG_RS02300	COG0081	regulation of translation
MLG_RS02305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MLG_RS02310	COG0222	ribosome binding
MLG_RS02315	COG0085	RNA polymerase activity
MLG_RS02320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MLG_RS02325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MLG_RS02330	COG0049	tRNA binding
MLG_RS02335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MLG_RS02340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MLG_RS02345	COG0051	transcription antitermination factor activity, RNA binding
MLG_RS02350	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MLG_RS02355	COG0088	Forms part of the polypeptide exit tunnel
MLG_RS02360	COG0089	rRNA binding
MLG_RS02365	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MLG_RS02370	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MLG_RS02375	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MLG_RS02380	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MLG_RS02385	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MLG_RS02390	COG0255	Belongs to the universal ribosomal protein uL29 family
MLG_RS02395	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MLG_RS02400	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MLG_RS02405	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MLG_RS02410	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MLG_RS02415	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MLG_RS02420	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MLG_RS02425	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MLG_RS02430	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MLG_RS02435	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MLG_RS02440	COG1841	ribosomal large subunit assembly
MLG_RS02445	COG0200	Binds to the 23S rRNA
MLG_RS02450	COG0201	protein transport
MLG_RS02455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MLG_RS02460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MLG_RS02465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MLG_RS02470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MLG_RS02475	COG0202	RNA polymerase activity
MLG_RS02480	COG0203	ribosomal protein L17
MLG_RS02495	COG0039	L-malate dehydrogenase activity
MLG_RS02505	COG0473	3-isopropylmalate dehydrogenase activity
MLG_RS02510	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MLG_RS02515	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MLG_RS02585	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MLG_RS02615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MLG_RS02635	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MLG_RS02640	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MLG_RS02665	COG1959	2 iron, 2 sulfur cluster binding
MLG_RS02665	COG1295	ribonuclease BN
MLG_RS02670	COG1254	Belongs to the acylphosphatase family
MLG_RS02720	COG3153	acetyltransferase
MLG_RS02720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MLG_RS02725	COG0729	surface antigen
MLG_RS02735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MLG_RS02740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MLG_RS02760	COG0442	prolyl-tRNA aminoacylation
MLG_RS02765	COG5001	Diguanylate cyclase
MLG_RS02765	COG3300	MHYT domain
MLG_RS02785	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MLG_RS02810	COG1183	phosphatidylcholine synthase activity
MLG_RS02815	COG0501	Belongs to the peptidase M48B family
MLG_RS02820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MLG_RS02825	COG1573	uracil-dna glycosylase
MLG_RS02830	COG1214	PFAM Peptidase M22, glycoprotease
MLG_RS02830	COG0456	acetyltransferase
MLG_RS02840	COG0525	valine-tRNA ligase activity
MLG_RS02855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MLG_RS02860	COG0795	lipopolysaccharide-transporting ATPase activity
MLG_RS02880	COG0617	tRNA 3'-terminal CCA addition
MLG_RS02885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MLG_RS02890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MLG_RS02895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MLG_RS02900	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MLG_RS02910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MLG_RS02910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MLG_RS02915	COG0802	atpase or kinase
MLG_RS02920	COG0860	N-Acetylmuramoyl-L-alanine amidase
MLG_RS02925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MLG_RS02930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MLG_RS02935	COG1923	regulation of RNA biosynthetic process
MLG_RS02940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MLG_RS02950	COG0330	HflC and HflK could
MLG_RS02955	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MLG_RS02960	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MLG_RS02975	COG0557	exoribonuclease II activity
MLG_RS02980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MLG_RS02985	COG0360	Binds together with S18 to 16S ribosomal RNA
MLG_RS02995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MLG_RS03005	COG0359	binds to the 23S rRNA
MLG_RS03015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MLG_RS03030	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MLG_RS03055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MLG_RS03070	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MLG_RS03075	COG1160	GTP binding
MLG_RS03080	COG0418	dihydroorotase activity
MLG_RS03090	COG3189	MarR family transcriptional regulator
MLG_RS03095	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
MLG_RS03100	COG0137	argininosuccinate synthase activity
MLG_RS03105	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MLG_RS03115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MLG_RS03125	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MLG_RS03135	COG2264	protein methyltransferase activity
MLG_RS03145	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MLG_RS03155	COG0151	Belongs to the GarS family
MLG_RS03185	COG0488	(ABC) transporter
MLG_RS03195	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MLG_RS03195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MLG_RS03210	COG0640	Transcriptional regulator
MLG_RS03215	COG1104	cysteine desulfurase activity
MLG_RS03220	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MLG_RS03225	COG2226	methyltransferase
MLG_RS03235	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MLG_RS03245	COG4251	negative regulation of phosphorylation
MLG_RS03245	COG5001	Diguanylate cyclase
MLG_RS03245	COG2203	Gaf domain
MLG_RS03245	COG3706	GGDEF domain
MLG_RS03255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MLG_RS03265	COG0243	molybdopterin cofactor binding
MLG_RS03280	COG0679	Auxin Efflux Carrier
MLG_RS03285	COG0582	viral genome integration into host DNA
MLG_RS03355	COG3501	Rhs element vgr protein
MLG_RS03370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MLG_RS03380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MLG_RS03385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MLG_RS03390	COG3263	regulation of cellular component size
MLG_RS03410	COG0517	IMP dehydrogenase activity
MLG_RS03425	COG0473	3-isopropylmalate dehydrogenase activity
MLG_RS03435	COG5002	protein histidine kinase activity
MLG_RS03445	COG2176	DNA-directed DNA polymerase activity
MLG_RS03445	COG5002	protein histidine kinase activity
MLG_RS03450	COG0745	RESPONSE REGULATOR receiver
MLG_RS03460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MLG_RS03470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MLG_RS03480	COG3852	Histidine kinase
MLG_RS03490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MLG_RS03500	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MLG_RS03505	COG1196	nuclear chromosome segregation
MLG_RS03515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MLG_RS03525	COG1509	lysine 2,3-aminomutase activity
MLG_RS03530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MLG_RS03535	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MLG_RS03545	COG0613	PHP domain protein
MLG_RS03550	COG0183	Belongs to the thiolase family
MLG_RS03555	COG5001	Diguanylate cyclase
MLG_RS03575	COG1570	exodeoxyribonuclease VII activity
MLG_RS03590	COG1013	pyruvate-flavodoxin oxidoreductase activity
MLG_RS03595	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MLG_RS03595	COG0674	pyruvate-flavodoxin oxidoreductase activity
MLG_RS03625	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MLG_RS03660	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MLG_RS03685	COG0501	Belongs to the peptidase M48B family
MLG_RS03700	COG2350	Protein conserved in bacteria
MLG_RS03705	COG0009	L-threonylcarbamoyladenylate synthase
MLG_RS03710	COG0180	Tryptophanyl-tRNA synthetase
MLG_RS03715	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MLG_RS03720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MLG_RS03730	COG1959	2 iron, 2 sulfur cluster binding
MLG_RS03735	COG0719	Fe-S assembly protein
MLG_RS03740	COG0396	ATPase activity
MLG_RS03745	COG0719	Fe-S assembly protein
MLG_RS03750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MLG_RS03770	COG0517	IMP dehydrogenase activity
MLG_RS03770	COG4175	Glycine betaine
MLG_RS03795	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MLG_RS03810	COG1320	monovalent cation:proton antiporter activity
MLG_RS03820	COG0713	ATP synthesis coupled electron transport
MLG_RS03825	COG0651	ATP synthesis coupled electron transport
MLG_RS03830	COG0651	ATP synthesis coupled electron transport
MLG_RS03840	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MLG_RS03850	COG3243	poly(R)-hydroxyalkanoic acid synthase
MLG_RS03855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MLG_RS03870	COG0398	Pfam SNARE associated Golgi protein
MLG_RS03885	COG1215	transferase activity, transferring glycosyl groups
MLG_RS03890	COG0640	Transcriptional regulator
MLG_RS03895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MLG_RS03925	COG0776	regulation of translation
MLG_RS03930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MLG_RS03930	COG0072	phenylalanine-tRNA ligase activity
MLG_RS03940	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MLG_RS03945	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MLG_RS03955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MLG_RS03970	COG4067	protein conserved in archaea
MLG_RS03970	COG0189	ligase activity
MLG_RS03990	COG2308	Evidence 4 Homologs of previously reported genes of
MLG_RS04035	COG0348	domain, Protein
MLG_RS04040	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
MLG_RS04050	COG1013	pyruvate-flavodoxin oxidoreductase activity
MLG_RS04055	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MLG_RS04055	COG0674	pyruvate-flavodoxin oxidoreductase activity
MLG_RS04120	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MLG_RS04130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MLG_RS04140	COG0489	protein tyrosine kinase activity
MLG_RS04140	COG3206	protein involved in exopolysaccharide biosynthesis
MLG_RS04155	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MLG_RS04160	COG1074	ATP-dependent DNA helicase activity
MLG_RS04165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MLG_RS04170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MLG_RS04175	COG0586	Pfam SNARE associated Golgi protein
MLG_RS04185	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MLG_RS04190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MLG_RS04195	COG4660	Part of a membrane complex involved in electron transport
MLG_RS04200	COG4659	FMN binding
MLG_RS04205	COG4658	electron transport chain
MLG_RS04215	COG2878	Part of a membrane complex involved in electron transport
MLG_RS04220	COG4657	Part of a membrane complex involved in electron transport
MLG_RS04225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MLG_RS04225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MLG_RS04230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MLG_RS04240	COG0501	Belongs to the peptidase M48B family
MLG_RS04245	COG1968	undecaprenyl-diphosphatase activity
MLG_RS04260	COG2239	Acts as a magnesium transporter
MLG_RS04265	COG0717	Belongs to the dCTP deaminase family
MLG_RS04285	COG0450	alkyl hydroperoxide reductase
MLG_RS04295	COG0720	synthase
MLG_RS04310	COG0142	geranyltranstransferase activity
MLG_RS04320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MLG_RS04335	COG3501	Rhs element vgr protein
MLG_RS04370	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MLG_RS04375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MLG_RS04380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MLG_RS04385	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MLG_RS04390	COG0268	Binds directly to 16S ribosomal RNA
MLG_RS04400	COG0196	riboflavin kinase activity
MLG_RS04405	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MLG_RS04415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MLG_RS04450	COG0688	phosphatidylethanolamine metabolic process
MLG_RS04470	COG2890	protein-(glutamine-N5) methyltransferase activity
MLG_RS04475	COG0501	Belongs to the peptidase M48B family
MLG_RS04490	COG0514	ATP-dependent DNA helicase (RecQ)
MLG_RS04515	COG1012	belongs to the aldehyde dehydrogenase family
MLG_RS04525	COG0436	Aminotransferase
MLG_RS04560	COG0228	four-way junction DNA binding
MLG_RS04565	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MLG_RS04570	COG0336	Belongs to the RNA methyltransferase TrmD family
MLG_RS04575	COG0335	large ribosomal subunit rRNA binding
MLG_RS04595	COG0835	chemotaxis
MLG_RS04595	COG0784	Response regulator, receiver
MLG_RS04605	COG1815	bacterial-type flagellum-dependent cell motility
MLG_RS04610	COG1558	bacterial-type flagellum-dependent cell motility
MLG_RS04620	COG1749	Flagellar hook protein flgE
MLG_RS04630	COG4786	Flagellar basal body rod
MLG_RS04645	COG1705	Flagellar rod assembly protein muramidase FlgJ
MLG_RS04645	COG3951	Flagellar rod assembly protein muramidase FlgJ
MLG_RS04665	COG1028	Short-chain dehydrogenase reductase Sdr
MLG_RS04670	COG1562	ergosterol biosynthetic process
MLG_RS04675	COG1181	Belongs to the D-alanine--D-alanine ligase family
MLG_RS04690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MLG_RS04695	COG0402	S-adenosylhomocysteine deaminase activity
MLG_RS04700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MLG_RS04705	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MLG_RS04710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MLG_RS04715	COG3047	cAMP biosynthetic process
MLG_RS04740	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MLG_RS04750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MLG_RS04760	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MLG_RS04765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MLG_RS04780	COG0287	Prephenate dehydrogenase
MLG_RS04785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MLG_RS04790	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MLG_RS04800	COG0776	regulation of translation
MLG_RS04810	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MLG_RS04815	COG0284	orotidine-5'-phosphate decarboxylase activity
MLG_RS04820	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MLG_RS04825	COG0586	Pfam SNARE associated Golgi protein
MLG_RS04845	COG1217	gtp-binding protein TYPA
MLG_RS04850	COG0037	tRNA processing
MLG_RS04855	COG1538	Outer membrane efflux protein
MLG_RS04860	COG1469	GTP cyclohydrolase I activity
MLG_RS04865	COG0142	geranyltranstransferase activity
MLG_RS04870	COG1722	exodeoxyribonuclease VII activity
MLG_RS04880	COG1518	maintenance of DNA repeat elements
MLG_RS04905	COG1203	CRISPR-associated helicase, Cas3
MLG_RS04915	COG0297	glycogen (starch) synthase activity
MLG_RS04920	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MLG_RS04925	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MLG_RS04985	COG1121	(ABC) transporter
MLG_RS05070	COG2198	Histidine kinase
MLG_RS05070	COG0784	Response regulator, receiver
MLG_RS05070	COG0643	Histidine kinase
MLG_RS05075	COG2201	protein-glutamate methylesterase activity
MLG_RS05080	COG1192	Involved in chromosome partitioning
MLG_RS05090	COG0835	chemotaxis
MLG_RS05100	COG1028	Short-chain dehydrogenase reductase Sdr
MLG_RS05105	COG1199	ATP-dependent helicase activity
MLG_RS05130	COG2181	nitrate reductase activity
MLG_RS05135	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
MLG_RS05140	COG1140	nitrate reductase beta subunit
MLG_RS05145	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MLG_RS05155	COG3850	Histidine kinase
MLG_RS05160	COG2197	response regulator
MLG_RS05165	COG2223	nitrite transmembrane transporter activity
MLG_RS05210	COG0519	Catalyzes the synthesis of GMP from XMP
MLG_RS05210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MLG_RS05215	COG0590	tRNA wobble adenosine to inosine editing
MLG_RS05220	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MLG_RS05230	COG2329	Antibiotic biosynthesis monooxygenase
MLG_RS05240	COG2832	Protein of unknown function (DUF454)
MLG_RS05245	COG1444	tRNA N-acetyltransferase activity
MLG_RS05250	COG0651	ATP synthesis coupled electron transport
MLG_RS05260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MLG_RS05265	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MLG_RS05280	COG4647	ligase activity
MLG_RS05285	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
MLG_RS05290	COG0145	ligase activity
MLG_RS05305	COG3108	Peptidase M15
MLG_RS05310	COG0301	tRNA thio-modification
MLG_RS05315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MLG_RS05320	COG1042	CoA-binding domain protein
MLG_RS05320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MLG_RS05320	COG0045	succinate-CoA ligase (ADP-forming) activity
MLG_RS05335	COG0346	lactoylglutathione lyase activity
MLG_RS05340	COG0803	Belongs to the bacterial solute-binding protein 9 family
MLG_RS05345	COG1121	(ABC) transporter
MLG_RS05350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MLG_RS05360	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MLG_RS05365	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MLG_RS05395	COG5001	Diguanylate cyclase
MLG_RS05400	COG5001	Diguanylate cyclase
MLG_RS05400	COG5002	protein histidine kinase activity
MLG_RS05400	COG3447	MASE1 domain protein
MLG_RS05425	COG1309	transcriptional regulator
MLG_RS05430	COG0543	2 iron, 2 sulfur cluster binding
MLG_RS05430	COG0493	'glutamate synthase
MLG_RS05495	COG3901	Regulator of nitric oxide reductase transcription
MLG_RS05495	COG0348	domain, Protein
MLG_RS05500	COG4263	nitrous-oxide reductase activity
MLG_RS05515	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MLG_RS05550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLG_RS05555	COG0601	transmembrane transport
MLG_RS05560	COG0747	negative chemotaxis
MLG_RS05565	COG0436	Aminotransferase
MLG_RS05590	COG1131	(ABC) transporter
MLG_RS05610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MLG_RS05615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MLG_RS05620	COG0840	transmembrane signaling receptor activity
MLG_RS05635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MLG_RS05640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MLG_RS05675	COG5002	protein histidine kinase activity
MLG_RS05675	COG5001	Diguanylate cyclase
MLG_RS05680	COG3973	AAA domain
MLG_RS05800	COG0573	inorganic phosphate transmembrane transporter activity
MLG_RS05805	COG0581	inorganic phosphate transmembrane transporter activity
MLG_RS05810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MLG_RS05815	COG0704	Plays a role in the regulation of phosphate uptake
MLG_RS05845	COG3501	Rhs element vgr protein
MLG_RS05890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MLG_RS05900	COG1199	ATP-dependent helicase activity
MLG_RS05920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MLG_RS05930	COG2010	Cytochrome c
MLG_RS05950	COG4536	flavin adenine dinucleotide binding
MLG_RS05955	COG0662	Cupin 2, conserved barrel domain protein
MLG_RS05960	COG1850	ribulose-bisphosphate carboxylase activity
MLG_RS05980	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MLG_RS05985	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MLG_RS05995	COG0587	DNA-directed DNA polymerase activity
MLG_RS06000	COG2814	Major facilitator Superfamily
MLG_RS06005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MLG_RS06005	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MLG_RS06025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MLG_RS06035	COG0011	TIGRFAM Protein of
MLG_RS06045	COG1509	lysine 2,3-aminomutase activity
MLG_RS06055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MLG_RS06070	COG1917	Cupin 2, conserved barrel domain protein
MLG_RS06075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MLG_RS06095	COG0735	belongs to the Fur family
MLG_RS06100	COG1121	(ABC) transporter
MLG_RS06105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MLG_RS06125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MLG_RS06140	COG1127	ABC transporter
MLG_RS06145	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MLG_RS06175	COG1546	Belongs to the CinA family
MLG_RS06175	COG1058	Belongs to the CinA family
MLG_RS06195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MLG_RS06200	COG0343	queuine tRNA-ribosyltransferase activity
MLG_RS06205	COG1862	Preprotein translocase
MLG_RS06210	COG1862	Preprotein translocase
MLG_RS06215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MLG_RS06230	COG2766	serine protein kinase
MLG_RS06235	COG2718	Belongs to the UPF0229 family
MLG_RS06240	COG2719	SpoVR family
MLG_RS06245	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MLG_RS06245	COG0678	peroxiredoxin activity
MLG_RS06255	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MLG_RS06260	COG2814	Major facilitator Superfamily
MLG_RS06265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MLG_RS06270	COG0066	3-isopropylmalate dehydratase activity
MLG_RS06275	COG0473	3-isopropylmalate dehydrogenase activity
MLG_RS06300	COG0135	phosphoribosylanthranilate isomerase activity
MLG_RS06305	COG0133	tryptophan synthase activity
MLG_RS06310	COG0159	tryptophan synthase activity
MLG_RS06315	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MLG_RS06320	COG0285	dihydrofolate synthase activity
MLG_RS06330	COG1286	toxin biosynthetic process
MLG_RS06350	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MLG_RS06360	COG0316	Belongs to the HesB IscA family
MLG_RS06365	COG0105	UTP biosynthetic process
MLG_RS06370	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MLG_RS06385	COG0124	histidyl-tRNA synthetase
MLG_RS06390	COG2976	Protein conserved in bacteria
MLG_RS06395	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MLG_RS06405	COG0563	adenylate kinase activity
MLG_RS06415	COG1335	isochorismatase
MLG_RS06425	COG2895	sulfate adenylyltransferase (ATP) activity
MLG_RS06425	COG0529	Catalyzes the synthesis of activated sulfate
MLG_RS06430	COG0175	sulfate reduction
MLG_RS06435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MLG_RS06435	COG1648	precorrin-2 dehydrogenase activity
MLG_RS06440	COG0175	sulfate reduction
MLG_RS06445	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MLG_RS06455	COG2863	cytochrome
MLG_RS06460	COG0446	pyridine nucleotide-disulphide oxidoreductase
MLG_RS06490	COG2715	membrane protein required for spore maturation
MLG_RS06505	COG0435	Glutathione S-transferase
MLG_RS06510	COG0655	NAD(P)H dehydrogenase (quinone) activity
MLG_RS06525	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MLG_RS06555	COG3383	formate dehydrogenase (NAD+) activity
MLG_RS06560	COG0437	4 iron, 4 sulfur cluster binding
MLG_RS06590	COG0432	Pfam Uncharacterised protein family UPF0047
MLG_RS06615	COG2414	aldehyde ferredoxin oxidoreductase
MLG_RS06620	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MLG_RS06625	COG0302	gtp cyclohydrolase
MLG_RS06630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MLG_RS06640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MLG_RS06655	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MLG_RS06660	COG0746	molybdenum cofactor guanylyltransferase activity
MLG_RS06670	COG0640	Transcriptional regulator
MLG_RS06680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MLG_RS06685	COG2204	response regulator
MLG_RS06700	COG0577	efflux transmembrane transporter activity
MLG_RS06710	COG0589	response to stress
MLG_RS06715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MLG_RS06720	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MLG_RS06730	COG1414	Transcriptional regulator
MLG_RS06740	COG2154	pterin-4-alpha-carbinolamine dehydratase
MLG_RS06745	COG0315	cyclic pyranopterin monophosphate synthase activity
MLG_RS06755	COG0588	phosphoglycerate mutase activity
MLG_RS06765	COG2954	triphosphatase activity
MLG_RS06775	COG1472	Belongs to the glycosyl hydrolase 3 family
MLG_RS06780	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MLG_RS06785	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MLG_RS06795	COG5508	conserved small protein
MLG_RS06815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MLG_RS06820	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MLG_RS06845	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MLG_RS06855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MLG_RS06860	COG0481	GTPase activity
MLG_RS06875	COG0571	ribonuclease III activity
MLG_RS06880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MLG_RS06885	COG1381	Involved in DNA repair and RecF pathway recombination
MLG_RS06890	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MLG_RS06895	COG0736	holo-[acyl-carrier-protein] synthase activity
MLG_RS06910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MLG_RS06915	COG0494	nUDIX hydrolase
MLG_RS06945	COG1573	uracil-dna glycosylase
MLG_RS06950	COG0322	excinuclease ABC activity
MLG_RS06955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MLG_RS06985	COG2095	MarC family integral membrane protein
MLG_RS06990	COG0300	oxidoreductase activity
MLG_RS06995	COG1994	Peptidase M50
MLG_RS06995	COG0517	IMP dehydrogenase activity
MLG_RS07005	COG1132	(ABC) transporter
MLG_RS07015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MLG_RS07025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MLG_RS07040	COG2204	response regulator
MLG_RS07045	COG0741	lytic transglycosylase activity
MLG_RS07060	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MLG_RS07065	COG2983	Belongs to the UPF0260 family
MLG_RS07070	COG2217	Heavy metal translocating P-type atpase
MLG_RS07095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MLG_RS07100	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MLG_RS07115	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MLG_RS07135	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MLG_RS07150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MLG_RS07165	COG0583	DNA-binding transcription factor activity
MLG_RS07170	COG3038	cytochrome b561
MLG_RS07185	COG1538	Outer membrane efflux protein
MLG_RS07195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MLG_RS07215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MLG_RS07230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MLG_RS07235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MLG_RS07240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MLG_RS07245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MLG_RS07250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MLG_RS07265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MLG_RS07270	COG0416	fatty acid biosynthetic process
MLG_RS07275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MLG_RS07280	COG1399	metal-binding, possibly nucleic acid-binding protein
MLG_RS07285	COG0424	maF-like protein
MLG_RS07290	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MLG_RS07290	COG0616	signal peptide processing
MLG_RS07295	COG0564	pseudouridine synthase activity
MLG_RS07305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MLG_RS07315	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MLG_RS07320	COG1663	tetraacyldisaccharide 4'-kinase activity
MLG_RS07325	COG0848	biopolymer transport protein
MLG_RS07330	COG0811	peptide transport
MLG_RS07335	COG2333	competence protein COMEC
MLG_RS07335	COG0658	competence protein
MLG_RS07345	COG1136	(ABC) transporter
MLG_RS07350	COG4591	ABC-type transport system involved in lipoprotein release permease component
MLG_RS07355	COG1489	DNA binding
MLG_RS07370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MLG_RS07375	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MLG_RS07380	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MLG_RS07385	COG0542	response to heat
MLG_RS07390	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MLG_RS07395	COG0583	DNA-binding transcription factor activity
MLG_RS07405	COG0482	sulfurtransferase activity
MLG_RS07410	COG2915	High frequency lysogenization protein hflD homolog
MLG_RS07435	COG3956	TIGRFAM MazG family protein
MLG_RS07440	COG1309	transcriptional regulator
MLG_RS07445	COG0625	glutathione transferase activity
MLG_RS07455	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MLG_RS07465	COG0167	dihydroorotate dehydrogenase activity
MLG_RS07470	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MLG_RS07475	COG2951	lytic endotransglycosylase activity
MLG_RS07490	COG1704	LemA family
MLG_RS07495	COG1752	Esterase of the alpha-beta hydrolase superfamily
MLG_RS07510	COG2183	response to ionizing radiation
MLG_RS07515	COG1643	Atp-dependent helicase
MLG_RS07555	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MLG_RS07560	COG0527	aspartate kinase activity
MLG_RS07565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MLG_RS07570	COG2137	regulation of response to DNA damage stimulus
MLG_RS07575	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MLG_RS07580	COG1546	Belongs to the CinA family
MLG_RS07585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MLG_RS07590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MLG_RS07595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MLG_RS07605	COG0330	HflC and HflK could
MLG_RS07610	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
MLG_RS07615	COG2166	iron-sulfur cluster assembly
MLG_RS07625	COG0446	pyridine nucleotide-disulphide oxidoreductase
MLG_RS07640	COG4251	negative regulation of phosphorylation
MLG_RS07645	COG2267	carboxylic ester hydrolase activity
MLG_RS07650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MLG_RS07660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLG_RS07665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MLG_RS07670	COG1162	GTPase activity
MLG_RS07675	COG1360	Flagellar Motor Protein
MLG_RS07690	COG0537	adenosine 5'-monophosphoramidase activity
MLG_RS07695	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MLG_RS07700	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MLG_RS07705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MLG_RS07710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MLG_RS07730	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MLG_RS07740	COG1067	ATP-dependent peptidase activity
MLG_RS07770	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MLG_RS07785	COG0463	Glycosyl transferase, family 2
MLG_RS07790	COG0521	Mo-molybdopterin cofactor biosynthetic process
MLG_RS07800	COG1073	alpha beta
MLG_RS07845	COG4372	Transposase
MLG_RS07855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MLG_RS07865	COG1196	nuclear chromosome segregation
MLG_RS07905	COG0463	Glycosyl transferase, family 2
MLG_RS07910	COG0521	Mo-molybdopterin cofactor biosynthetic process
MLG_RS07930	COG0129	dihydroxy-acid dehydratase activity
MLG_RS07955	COG0489	protein tyrosine kinase activity
MLG_RS07975	COG5000	phosphorelay sensor kinase activity
MLG_RS07975	COG3279	Response regulator of the LytR AlgR family
MLG_RS08005	COG3608	succinylglutamate desuccinylase aspartoacylase
MLG_RS08005	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MLG_RS08025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MLG_RS08050	COG1136	(ABC) transporter
MLG_RS08050	COG0577	efflux transmembrane transporter activity
MLG_RS08065	COG0084	hydrolase, TatD family'
MLG_RS08070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MLG_RS08095	COG0494	nUDIX hydrolase
MLG_RS08100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MLG_RS08130	COG0308	aminopeptidase N
MLG_RS08135	COG0793	Belongs to the peptidase S41A family
MLG_RS08140	COG1024	Enoyl-CoA hydratase
MLG_RS08170	COG1160	GTP binding
MLG_RS08185	COG2095	MarC family integral membrane protein
MLG_RS08200	COG1763	Mo-molybdopterin cofactor biosynthetic process
MLG_RS08210	COG0519	Catalyzes the synthesis of GMP from XMP
MLG_RS08210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MLG_RS08215	COG1193	negative regulation of DNA recombination
MLG_RS08230	COG2226	methyltransferase
MLG_RS08235	COG1671	Belongs to the UPF0178 family
MLG_RS08240	COG0513	Belongs to the DEAD box helicase family
MLG_RS08255	COG1881	PFAM PEBP family protein
MLG_RS08260	COG4251	negative regulation of phosphorylation
MLG_RS08275	COG4191	Histidine kinase
MLG_RS08310	COG1643	Atp-dependent helicase
MLG_RS08345	COG2226	methyltransferase
MLG_RS08350	COG1595	DNA-templated transcription, initiation
MLG_RS08360	COG2226	methyltransferase
MLG_RS08365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MLG_RS08365	COG0519	Catalyzes the synthesis of GMP from XMP
MLG_RS08390	COG4191	Histidine kinase
MLG_RS08395	COG4988	ABC transporter
MLG_RS08400	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MLG_RS08405	COG5001	Diguanylate cyclase
MLG_RS08410	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MLG_RS08445	COG2221	Nitrite and sulphite reductase 4Fe-4S
MLG_RS08450	COG2221	Nitrite and sulphite reductase 4Fe-4S
MLG_RS08455	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MLG_RS08460	COG2923	Belongs to the DsrF TusC family
MLG_RS08470	COG2920	part of a sulfur-relay system
MLG_RS08505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MLG_RS08510	COG1797	cobyrinic acid a,c-diamide synthase activity
MLG_RS08525	COG2197	response regulator
MLG_RS08530	COG4585	Histidine kinase
MLG_RS08540	COG0425	Belongs to the sulfur carrier protein TusA family
MLG_RS08550	COG0446	pyridine nucleotide-disulphide oxidoreductase
MLG_RS08555	COG0243	molybdopterin cofactor binding
MLG_RS08560	COG0437	4 iron, 4 sulfur cluster binding
MLG_RS08565	COG3302	dmso reductase anchor subunit
MLG_RS08570	COG3005	denitrification pathway
MLG_RS08575	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MLG_RS08575	COG1648	precorrin-2 dehydrogenase activity
MLG_RS08580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MLG_RS08595	COG4133	protoheme IX ABC transporter activity
MLG_RS08610	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MLG_RS08615	COG1138	Cytochrome C-type biogenesis protein
MLG_RS08620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MLG_RS08625	COG3088	subunit of a heme lyase
MLG_RS08630	COG4235	cytochrome complex assembly
MLG_RS08640	COG2027	D-alanyl-D-alanine carboxypeptidase
MLG_RS08650	COG0628	permease
MLG_RS08655	COG4191	Histidine kinase
MLG_RS08660	COG2204	response regulator
MLG_RS08675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MLG_RS08680	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MLG_RS08685	COG2146	nitrite reductase [NAD(P)H] activity
MLG_RS08690	COG0243	molybdopterin cofactor binding
MLG_RS08695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MLG_RS08695	COG1116	anion transmembrane transporter activity
MLG_RS08705	COG1116	anion transmembrane transporter activity
MLG_RS08720	COG3707	response regulator
MLG_RS08730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MLG_RS08735	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MLG_RS08740	COG1674	ftsk spoiiie
MLG_RS08745	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MLG_RS08750	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MLG_RS08760	COG1234	tRNA 3'-trailer cleavage
MLG_RS08770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MLG_RS08775	COG1960	acyl-CoA dehydrogenase activity
MLG_RS08790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MLG_RS08805	COG2081	HI0933 family
MLG_RS08810	COG0121	glutamine amidotransferase
MLG_RS08855	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MLG_RS08865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MLG_RS08875	COG1283	sodium-dependent phosphate transmembrane transporter activity
MLG_RS08945	COG1222	aaa ATPase
MLG_RS08975	COG1575	Belongs to the MenA family. Type 1 subfamily
MLG_RS09000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MLG_RS09020	COG2610	gluconate transmembrane transporter activity
MLG_RS09035	COG3977	Valine--pyruvate aminotransferase
MLG_RS09040	COG0038	chloride channel
MLG_RS09050	COG3239	Fatty acid desaturase
MLG_RS09055	COG1214	PFAM Peptidase M22, glycoprotease
MLG_RS09055	COG0456	acetyltransferase
MLG_RS09060	COG0640	Transcriptional regulator
MLG_RS09090	COG4372	Transposase
MLG_RS09115	COG2161	toxin-antitoxin pair type II binding
MLG_RS09150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MLG_RS09175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MLG_RS09185	COG3706	GGDEF domain
MLG_RS09195	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MLG_RS09205	COG0215	cysteine-tRNA ligase activity
MLG_RS09210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MLG_RS09215	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MLG_RS09220	COG0352	thiamine-phosphate diphosphorylase activity
MLG_RS09220	COG0351	phosphomethylpyrimidine kinase
MLG_RS09230	COG1999	signal sequence binding
MLG_RS09245	COG2738	Putative neutral zinc metallopeptidase
MLG_RS09250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MLG_RS09260	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MLG_RS09270	COG0436	Aminotransferase
MLG_RS09285	COG4942	peptidase
MLG_RS09285	COG1388	LysM domain
MLG_RS09290	COG1238	metal cluster binding
MLG_RS09295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MLG_RS09300	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MLG_RS09310	COG5001	Diguanylate cyclase
MLG_RS09310	COG3447	MASE1 domain protein
MLG_RS09310	COG5002	protein histidine kinase activity
MLG_RS09315	COG4566	intracellular signal transduction
MLG_RS09325	COG2197	response regulator
MLG_RS09330	COG0585	pseudouridine synthase activity
MLG_RS09335	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MLG_RS09340	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MLG_RS09345	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MLG_RS09350	COG0148	phosphopyruvate hydratase activity
MLG_RS09355	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MLG_RS09360	COG0504	CTP synthase activity
MLG_RS09365	COG0037	tRNA processing
MLG_RS09370	COG0825	malonyl-CoA metabolic process
MLG_RS09390	COG0848	biopolymer transport protein
MLG_RS09395	COG0811	peptide transport
MLG_RS09405	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MLG_RS09410	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MLG_RS09415	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MLG_RS09420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MLG_RS09440	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MLG_RS09445	COG0575	Belongs to the CDS family
MLG_RS09450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MLG_RS09455	COG0233	cytoplasmic translational termination
MLG_RS09460	COG0528	UMP kinase activity
MLG_RS09465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MLG_RS09470	COG0052	Belongs to the universal ribosomal protein uS2 family
MLG_RS09475	COG0024	Methionine aminopeptidase
MLG_RS09485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MLG_RS09490	COG2171	N-acyltransferase activity
MLG_RS09495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MLG_RS09510	COG0248	Ppx GppA phosphatase
MLG_RS09515	COG2062	phosphohistidine phosphatase, SixA
MLG_RS09530	COG2217	Heavy metal translocating P-type atpase
MLG_RS09540	COG0348	domain, Protein
MLG_RS09550	COG2010	Cytochrome c
MLG_RS09565	COG3278	Belongs to the heme-copper respiratory oxidase family
MLG_RS09570	COG0714	Associated with various cellular activities
MLG_RS09590	COG1959	2 iron, 2 sulfur cluster binding
MLG_RS09600	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MLG_RS09615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MLG_RS09625	COG0277	FAD linked oxidase domain protein
MLG_RS09630	COG0277	FAD linked oxidase domain protein
MLG_RS09635	COG0247	lactate metabolic process
MLG_RS09645	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MLG_RS09650	COG0484	heat shock protein binding
MLG_RS09655	COG0443	Heat shock 70 kDa protein
MLG_RS09660	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MLG_RS09665	COG1420	regulation of RNA biosynthetic process
MLG_RS09675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MLG_RS09680	COG0497	DNA recombination
MLG_RS09685	COG0735	belongs to the Fur family
MLG_RS09690	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MLG_RS09695	COG2914	Belongs to the UPF0125 (RnfH) family
MLG_RS09700	COG2867	negative regulation of translational initiation
MLG_RS09705	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MLG_RS09725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MLG_RS09725	COG4797	methyltransferase
MLG_RS09775	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MLG_RS09790	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MLG_RS09790	COG3608	succinylglutamate desuccinylase aspartoacylase
MLG_RS09805	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MLG_RS09810	COG5001	Diguanylate cyclase
MLG_RS09810	COG3300	MHYT domain
MLG_RS09840	COG0471	metal ion transport
MLG_RS09850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MLG_RS09875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MLG_RS09880	COG1185	polyribonucleotide nucleotidyltransferase activity
MLG_RS09885	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MLG_RS09890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MLG_RS09895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MLG_RS09900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MLG_RS09905	COG2251	uridine kinase activity
MLG_RS09905	COG0195	Participates in both transcription termination and antitermination
MLG_RS09910	COG0779	Required for maturation of 30S ribosomal subunits
MLG_RS09920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MLG_RS09920	COG0116	Belongs to the methyltransferase superfamily
MLG_RS09935	COG0564	pseudouridine synthase activity
MLG_RS09945	COG1007	ATP synthesis coupled electron transport
MLG_RS09960	COG0713	ATP synthesis coupled electron transport
MLG_RS09970	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MLG_RS09975	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MLG_RS09980	COG1034	ATP synthesis coupled electron transport
MLG_RS09995	COG0649	NAD binding
MLG_RS10000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MLG_RS10005	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MLG_RS10010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MLG_RS10020	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MLG_RS10025	COG0149	triose-phosphate isomerase activity
MLG_RS10030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MLG_RS10035	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MLG_RS10040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MLG_RS10045	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MLG_RS10055	COG1534	Rna-binding protein
MLG_RS10065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MLG_RS10075	COG0505	Belongs to the CarA family
MLG_RS10080	COG1131	(ABC) transporter
MLG_RS10085	COG0842	Transport permease protein
MLG_RS10105	COG0259	pyridoxamine-phosphate oxidase activity
MLG_RS10115	COG1011	Hydrolase
MLG_RS10120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MLG_RS10125	COG0328	RNA-DNA hybrid ribonuclease activity
MLG_RS10135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MLG_RS10140	COG1388	LysM domain
MLG_RS10140	COG0741	lytic transglycosylase activity
MLG_RS10145	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MLG_RS10150	COG2894	cell division
MLG_RS10155	COG0850	regulation of cytokinetic process
MLG_RS10180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MLG_RS10185	COG0617	tRNA 3'-terminal CCA addition
MLG_RS10185	COG0517	IMP dehydrogenase activity
MLG_RS10185	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MLG_RS10195	COG5002	protein histidine kinase activity
MLG_RS10195	COG2176	DNA-directed DNA polymerase activity
MLG_RS10200	COG0326	Molecular chaperone. Has ATPase activity
MLG_RS10225	COG2204	response regulator
MLG_RS10230	COG1024	Enoyl-CoA hydratase
MLG_RS10230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MLG_RS10240	COG0409	Hydrogenase expression formation protein
MLG_RS10250	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MLG_RS10260	COG0375	protein maturation
MLG_RS10280	COG1773	rubredoxin
MLG_RS10300	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
MLG_RS10310	COG4771	TonB-dependent receptor
MLG_RS10325	COG0310	cobalt ion transport
MLG_RS10335	COG1122	ATPase activity
MLG_RS10345	COG0028	Belongs to the TPP enzyme family
MLG_RS10350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MLG_RS10360	COG0560	Phosphoserine phosphatase
MLG_RS10360	COG3830	Belongs to the UPF0237 family
MLG_RS10365	COG3300	MHYT domain
MLG_RS10365	COG5001	Diguanylate cyclase
MLG_RS10375	COG1294	oxidase, subunit
MLG_RS10380	COG1271	oxidase subunit
MLG_RS10385	COG0730	response to heat
MLG_RS10405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MLG_RS10420	COG5002	protein histidine kinase activity
MLG_RS10420	COG2176	DNA-directed DNA polymerase activity
MLG_RS10445	COG3938	Belongs to the proline racemase family
MLG_RS10450	COG0604	alcohol dehydrogenase
MLG_RS10465	COG0668	transmembrane transport
MLG_RS10470	COG0309	Hydrogenase expression formation protein (HypE)
MLG_RS10480	COG1720	tRNA m6t6A37 methyltransferase activity
MLG_RS10485	COG5001	Diguanylate cyclase
MLG_RS10490	COG0352	thiamine-phosphate diphosphorylase activity
MLG_RS10495	COG1773	rubredoxin
MLG_RS10525	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MLG_RS10525	COG0617	tRNA 3'-terminal CCA addition
MLG_RS10525	COG0517	IMP dehydrogenase activity
MLG_RS10540	COG2199	diguanylate cyclase activity
MLG_RS10565	COG0237	dephospho-CoA kinase activity
MLG_RS10570	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MLG_RS10575	COG0494	nUDIX hydrolase
MLG_RS10580	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MLG_RS10585	COG0653	protein targeting
MLG_RS10600	COG1830	Aldolase
MLG_RS10605	COG2111	Na H antiporter
MLG_RS10605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MLG_RS10610	COG2111	Na H antiporter
MLG_RS10615	COG1006	Multisubunit Na H antiporter MnhC subunit
MLG_RS10620	COG0651	ATP synthesis coupled electron transport
MLG_RS10625	COG1863	multisubunit Na H antiporter MnhE subunit
MLG_RS10630	COG2212	antiporter activity
MLG_RS10635	COG1320	monovalent cation:proton antiporter activity
MLG_RS10645	COG0488	(ABC) transporter
MLG_RS10650	COG0788	formyltetrahydrofolate deformylase activity
MLG_RS10670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MLG_RS10675	COG0583	DNA-binding transcription factor activity
MLG_RS10680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MLG_RS10685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MLG_RS10695	COG0183	Belongs to the thiolase family
MLG_RS10710	COG2067	long-chain fatty acid transport protein
MLG_RS10715	COG0175	sulfate reduction
MLG_RS10740	COG0714	Associated with various cellular activities
MLG_RS10765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MLG_RS10770	COG1960	acyl-CoA dehydrogenase activity
MLG_RS10775	COG0183	Belongs to the thiolase family
MLG_RS10780	COG1024	Enoyl-CoA hydratase
MLG_RS10780	COG1250	3-hydroxyacyl-CoA dehydrogenase
MLG_RS10785	COG1022	Amp-dependent synthetase and ligase
MLG_RS10790	COG1960	acyl-CoA dehydrogenase activity
MLG_RS10795	COG1309	transcriptional regulator
MLG_RS10815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MLG_RS10820	COG3154	lipid carrier protein
MLG_RS10825	COG0826	peptidase U32
MLG_RS10830	COG0826	peptidase U32
MLG_RS10835	COG1063	alcohol dehydrogenase
MLG_RS10845	COG1126	abc transporter atp-binding protein
MLG_RS10850	COG0765	amino acid transport
MLG_RS10855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLG_RS10860	COG2135	peptidase activity
MLG_RS10885	COG1136	(ABC) transporter
MLG_RS10885	COG0577	efflux transmembrane transporter activity
MLG_RS10890	COG1136	(ABC) transporter
MLG_RS10890	COG0577	efflux transmembrane transporter activity
MLG_RS10915	COG4566	intracellular signal transduction
MLG_RS10960	COG4964	Belongs to the GSP D family
MLG_RS10980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MLG_RS10985	COG2274	protein secretion by the type I secretion system
MLG_RS11000	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MLG_RS11000	COG2885	chlorophyll binding
MLG_RS11005	COG5001	Diguanylate cyclase
MLG_RS11020	COG1739	Uncharacterized protein family UPF0029
MLG_RS11030	COG4608	Belongs to the ABC transporter superfamily
MLG_RS11035	COG0444	Belongs to the ABC transporter superfamily
MLG_RS11070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MLG_RS11080	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MLG_RS11095	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MLG_RS11100	COG1181	Belongs to the D-alanine--D-alanine ligase family
MLG_RS11105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MLG_RS11110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MLG_RS11115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MLG_RS11120	COG0772	Belongs to the SEDS family
MLG_RS11125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MLG_RS11130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MLG_RS11135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MLG_RS11140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MLG_RS11155	COG0275	rRNA processing
MLG_RS11160	COG2001	Belongs to the MraZ family
MLG_RS11165	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MLG_RS11175	COG0792	nuclease activity
MLG_RS11180	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MLG_RS11185	COG2969	positive regulation of protein catabolic process
MLG_RS11190	COG0625	glutathione transferase activity
MLG_RS11195	COG2857	Cytochrome c1
MLG_RS11200	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MLG_RS11205	COG0723	plastoquinol--plastocyanin reductase activity
MLG_RS11220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MLG_RS11230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MLG_RS11235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MLG_RS11255	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MLG_RS11260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MLG_RS11265	COG1127	ABC transporter
MLG_RS11270	COG0530	calcium, potassium:sodium antiporter activity
MLG_RS11280	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MLG_RS11290	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MLG_RS11295	COG1137	ATPase activity
MLG_RS11315	COG1660	Displays ATPase and GTPase activities
MLG_RS11330	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MLG_RS11335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MLG_RS11345	COG3243	poly(R)-hydroxyalkanoic acid synthase
MLG_RS11350	COG0742	ribosomal rna small subunit methyltransferase
MLG_RS11360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MLG_RS11365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MLG_RS11375	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MLG_RS11380	COG1765	OsmC-like protein
MLG_RS11390	COG0134	indole-3-glycerol-phosphate synthase activity
MLG_RS11395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MLG_RS11410	COG0546	phosphoglycolate phosphatase activity
MLG_RS11415	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MLG_RS11425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MLG_RS11435	COG0415	Belongs to the DNA photolyase family
MLG_RS11440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MLG_RS11445	COG0179	Fumarylacetoacetate (FAA) hydrolase
MLG_RS11450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MLG_RS11455	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MLG_RS11460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MLG_RS11465	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MLG_RS11475	COG0189	ligase activity
MLG_RS11475	COG4067	protein conserved in archaea
MLG_RS11480	COG0189	ligase activity
MLG_RS11495	COG4172	Belongs to the ABC transporter superfamily
MLG_RS11500	COG4239	(ABC) transporter, permease
MLG_RS11505	COG4174	ABC transporter (Permease)
MLG_RS11515	COG4166	transmembrane transport
MLG_RS11525	COG4771	TonB-dependent receptor
MLG_RS11540	COG1620	l-lactate permease
MLG_RS11550	COG1139	Iron-sulfur cluster binding protein
MLG_RS11555	COG0247	lactate metabolic process
MLG_RS11565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MLG_RS11590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MLG_RS11595	COG0740	serine-type endopeptidase activity
MLG_RS11600	COG0544	peptidyl-prolyl cis-trans isomerase activity
MLG_RS11640	COG4942	peptidase
MLG_RS11660	COG3550	peptidyl-serine autophosphorylation
MLG_RS11695	COG1396	sequence-specific DNA binding
MLG_RS11710	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MLG_RS11715	COG1196	nuclear chromosome segregation
MLG_RS11730	COG1088	dTDP-glucose 4,6-dehydratase activity
MLG_RS11735	COG1091	dTDP-4-dehydrorhamnose reductase activity
MLG_RS11750	COG1132	(ABC) transporter
MLG_RS11755	COG1086	Polysaccharide biosynthesis protein
MLG_RS11760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MLG_RS11765	COG1083	cytidylyl-transferase
MLG_RS11780	COG2089	acid synthase
MLG_RS11845	COG0175	sulfate reduction
MLG_RS11860	COG0471	metal ion transport
MLG_RS11860	COG3273	potassium ion transport
MLG_RS11870	COG1686	Belongs to the peptidase S11 family
MLG_RS11890	COG1215	transferase activity, transferring glycosyl groups
MLG_RS11900	COG1132	(ABC) transporter
MLG_RS11910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MLG_RS11920	COG4638	Rieske (2fe-2S)
MLG_RS11930	COG1012	belongs to the aldehyde dehydrogenase family
MLG_RS11935	COG0473	3-isopropylmalate dehydrogenase activity
MLG_RS11950	COG0438	transferase activity, transferring glycosyl groups
MLG_RS11955	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MLG_RS11970	COG2089	acid synthase
MLG_RS12010	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MLG_RS12015	COG0280	phosphate acetyltransferase
MLG_RS12020	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MLG_RS12025	COG3243	poly(R)-hydroxyalkanoic acid synthase
MLG_RS12060	COG3156	type II secretion system protein K
MLG_RS12090	COG1459	type II secretion system
MLG_RS12145	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MLG_RS12165	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MLG_RS12170	COG4181	ATPase activity
MLG_RS12185	COG2974	May be involved in recombination
MLG_RS12190	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MLG_RS12210	COG1047	Peptidyl-prolyl cis-trans
MLG_RS12220	COG3360	Dodecin
MLG_RS12230	COG3065	identical protein binding
MLG_RS12240	COG0288	reversible hydration of carbon dioxide
MLG_RS12255	COG0488	(ABC) transporter
MLG_RS12265	COG0243	molybdopterin cofactor binding
MLG_RS12270	COG0437	4 iron, 4 sulfur cluster binding
MLG_RS12300	COG2226	methyltransferase
MLG_RS12310	COG0156	8-amino-7-oxononanoate synthase activity
MLG_RS12315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MLG_RS12320	COG1040	competence protein
MLG_RS12325	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MLG_RS12330	COG3161	chorismate lyase activity
MLG_RS12335	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MLG_RS12345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MLG_RS12350	COG1758	RNA polymerase activity
MLG_RS12355	COG0194	GDP metabolic process
MLG_RS12360	COG1561	YicC-like family, N-terminal region
MLG_RS12365	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MLG_RS12370	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MLG_RS12375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MLG_RS12400	COG0154	amidase activity
MLG_RS12420	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MLG_RS12420	COG0316	Belongs to the HesB IscA family
MLG_RS12440	COG4569	acetaldehyde dehydrogenase (acetylating) activity
MLG_RS12445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MLG_RS12450	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MLG_RS12455	COG0678	peroxiredoxin activity
MLG_RS12455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MLG_RS12470	COG2409	Drug exporters of the RND superfamily
MLG_RS12500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MLG_RS12505	COG0047	phosphoribosylformylglycinamidine synthase activity
MLG_RS12505	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MLG_RS12510	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MLG_RS12515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MLG_RS12535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MLG_RS12540	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MLG_RS12550	COG4783	chaperone-mediated protein folding
MLG_RS12560	COG3243	poly(R)-hydroxyalkanoic acid synthase
MLG_RS12565	COG1028	Short-chain dehydrogenase reductase Sdr
MLG_RS12585	COG0318	PFAM AMP-dependent synthetase and ligase
MLG_RS12595	COG0217	transcriptional regulatory protein
MLG_RS12600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MLG_RS12605	COG0632	four-way junction helicase activity
MLG_RS12615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MLG_RS12630	COG2210	Belongs to the sulfur carrier protein TusA family
MLG_RS12690	COG0429	hydrolase of the alpha beta-hydrolase fold
MLG_RS12705	COG3383	formate dehydrogenase (NAD+) activity
MLG_RS12715	COG0346	lactoylglutathione lyase activity
MLG_RS12730	COG0358	DNA primase activity
MLG_RS12735	COG1610	YqeY-like protein
MLG_RS12740	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MLG_RS12745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MLG_RS12750	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MLG_RS12755	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MLG_RS12760	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MLG_RS12775	COG1515	deoxyribonuclease V activity
MLG_RS12795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MLG_RS12795	COG0543	2 iron, 2 sulfur cluster binding
MLG_RS12800	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MLG_RS12805	COG1943	Transposase
MLG_RS12810	COG0339	signal peptide processing
MLG_RS12815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MLG_RS12820	COG2945	thiolester hydrolase activity
MLG_RS12835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MLG_RS12850	COG3079	Belongs to the UPF0149 family
MLG_RS12855	COG0006	proline dipeptidase activity
MLG_RS12860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MLG_RS12865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MLG_RS12880	COG0045	succinate-CoA ligase (ADP-forming) activity
MLG_RS12885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MLG_RS12925	COG1458	PINc domain ribonuclease
MLG_RS12935	COG0542	response to heat
MLG_RS12955	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MLG_RS12960	COG2084	Dehydrogenase
MLG_RS12965	COG0693	protein deglycase activity
MLG_RS12970	COG2861	carbohydrate metabolic process
MLG_RS12975	COG0793	Belongs to the peptidase S41A family
MLG_RS12980	COG4942	peptidase
MLG_RS12990	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MLG_RS12995	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MLG_RS13000	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MLG_RS13010	COG1178	ABC-type Fe3 transport system permease component
MLG_RS13015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MLG_RS13020	COG0509	glycine decarboxylation via glycine cleavage system
MLG_RS13025	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MLG_RS13030	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MLG_RS13035	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MLG_RS13060	COG0493	'glutamate synthase
MLG_RS13060	COG0543	2 iron, 2 sulfur cluster binding
MLG_RS13070	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
MLG_RS13075	COG1116	anion transmembrane transporter activity
MLG_RS13080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MLG_RS13085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MLG_RS13085	COG1116	anion transmembrane transporter activity
MLG_RS13095	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MLG_RS13105	COG0523	cobalamin synthesis protein
MLG_RS13125	COG0022	dehydrogenase e1 component
MLG_RS13125	COG0508	dehydrogenase complex catalyzes the overall conversion of
MLG_RS13130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MLG_RS13150	COG2079	MmgE PrpD family protein
MLG_RS13160	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MLG_RS13165	COG0372	Belongs to the citrate synthase family
MLG_RS13170	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MLG_RS13175	COG0604	alcohol dehydrogenase
MLG_RS13205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MLG_RS13210	COG0140	phosphoribosyl-ATP diphosphatase activity
MLG_RS13215	COG0107	imidazoleglycerol-phosphate synthase activity
MLG_RS13220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MLG_RS13225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MLG_RS13230	COG0131	Imidazoleglycerol-phosphate dehydratase
MLG_RS13235	COG1490	D-aminoacyl-tRNA deacylase activity
MLG_RS13245	COG1560	Kdo2-lipid A biosynthetic process
MLG_RS13255	COG0569	domain protein
MLG_RS13260	COG2204	response regulator
MLG_RS13265	COG5000	phosphorelay sensor kinase activity
MLG_RS13280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MLG_RS13285	COG0242	peptide deformylase activity
MLG_RS13295	COG0758	DNA mediated transformation
MLG_RS13300	COG2922	Belongs to the Smg family
MLG_RS13305	COG1754	DNA topoisomerase type I activity
MLG_RS13305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MLG_RS13310	COG0009	L-threonylcarbamoyladenylate synthase
MLG_RS13315	COG0408	coproporphyrinogen oxidase activity
MLG_RS13325	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MLG_RS13335	COG1560	Kdo2-lipid A biosynthetic process
MLG_RS13340	COG1538	Outer membrane efflux protein
MLG_RS13345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MLG_RS13350	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MLG_RS13355	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MLG_RS13390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MLG_RS13395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MLG_RS13410	COG3706	GGDEF domain
MLG_RS13415	COG0405	Gamma-glutamyltransferase
MLG_RS13420	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MLG_RS13425	COG0742	ribosomal rna small subunit methyltransferase
MLG_RS13430	COG0612	Peptidase, M16
MLG_RS13435	COG0612	Peptidase, M16
MLG_RS13440	COG0552	protein localization to endoplasmic reticulum
MLG_RS13445	COG2884	Cell division ATP-binding protein ftsE
MLG_RS13450	COG2177	Part of the ABC transporter FtsEX involved in
MLG_RS13465	COG2003	Belongs to the UPF0758 family
MLG_RS13470	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MLG_RS13495	COG0181	hydroxymethylbilane synthase activity
MLG_RS13505	COG3275	phosphorelay sensor kinase activity
MLG_RS13510	COG0165	Argininosuccinate lyase
MLG_RS13515	COG0517	IMP dehydrogenase activity
MLG_RS13595	COG0521	Mo-molybdopterin cofactor biosynthetic process
MLG_RS13600	COG1562	ergosterol biosynthetic process
MLG_RS13605	COG3001	Fructosamine kinase
MLG_RS13610	COG2226	methyltransferase
MLG_RS13620	COG2982	Protein involved in outer membrane biogenesis
MLG_RS13625	COG1194	a g-specific adenine glycosylase
MLG_RS13630	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MLG_RS13640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MLG_RS13645	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MLG_RS13685	COG0183	Belongs to the thiolase family
MLG_RS13690	COG0589	response to stress
MLG_RS13700	COG0798	PFAM Bile acid sodium symporter
MLG_RS13715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MLG_RS13720	COG0640	Transcriptional regulator
MLG_RS13755	COG0659	secondary active sulfate transmembrane transporter activity
MLG_RS13765	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MLG_RS13770	COG2197	response regulator
MLG_RS13775	COG3851	Histidine kinase
MLG_RS13780	COG4772	TonB-dependent receptor
MLG_RS13790	COG1012	belongs to the aldehyde dehydrogenase family
MLG_RS13800	COG4772	TonB-dependent receptor
MLG_RS13815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLG_RS13840	COG3284	Transcriptional regulator
MLG_RS13845	COG2133	pyrroloquinoline quinone binding
MLG_RS13855	COG1122	ATPase activity
MLG_RS13890	COG0629	single-stranded DNA binding
MLG_RS13895	COG2814	Major facilitator Superfamily
MLG_RS13900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MLG_RS13905	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MLG_RS13915	COG0254	rRNA binding
MLG_RS13920	COG0372	Belongs to the citrate synthase family
MLG_RS13965	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MLG_RS13970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MLG_RS13975	COG0067	glutamate synthase
MLG_RS13975	COG0069	glutamate synthase activity
MLG_RS13975	COG0070	glutamate synthase
MLG_RS13980	COG0493	'glutamate synthase
MLG_RS13985	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MLG_RS14030	COG0018	arginyl-trna synthetase
MLG_RS14035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MLG_RS14045	COG2255	four-way junction helicase activity
MLG_RS14050	COG0235	Class ii aldolase
MLG_RS14055	COG2902	Dehydrogenase
MLG_RS14065	COG0596	Alpha beta hydrolase
MLG_RS14070	COG0708	Exodeoxyribonuclease III
MLG_RS14080	COG0668	transmembrane transport
MLG_RS14100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MLG_RS14105	COG1802	Transcriptional regulator
MLG_RS14110	COG0318	PFAM AMP-dependent synthetase and ligase
MLG_RS14120	COG0859	PFAM glycosyl transferase family 9
MLG_RS14125	COG0438	transferase activity, transferring glycosyl groups
MLG_RS14130	COG0515	serine threonine protein kinase
MLG_RS14170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MLG_RS14175	COG1132	(ABC) transporter
MLG_RS14185	COG1560	Kdo2-lipid A biosynthetic process
MLG_RS14190	COG0859	PFAM glycosyl transferase family 9
MLG_RS14205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MLG_RS14210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MLG_RS14210	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MLG_RS14215	COG2030	dehydratase
MLG_RS14220	COG1492	cobalamin metabolic process
MLG_RS14225	COG1797	cobyrinic acid a,c-diamide synthase activity
MLG_RS14235	COG4206	TonB-dependent receptor
MLG_RS14240	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MLG_RS14260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MLG_RS14265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLG_RS14270	COG1120	ATPase activity
MLG_RS14285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MLG_RS14290	COG0306	phosphate transporter
MLG_RS14295	COG1392	Phosphate transport regulator
MLG_RS14315	COG1360	Flagellar Motor Protein
MLG_RS14325	COG3954	Phosphoribulokinase
MLG_RS14330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MLG_RS14340	COG1850	ribulose-bisphosphate carboxylase activity
MLG_RS14360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MLG_RS14365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MLG_RS14370	COG0126	phosphoglycerate kinase activity
MLG_RS14375	COG0469	pyruvate kinase activity
MLG_RS14380	COG0191	fructose-bisphosphate aldolase activity
MLG_RS14390	COG0756	dUTP diphosphatase activity
MLG_RS14395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MLG_RS14400	COG0733	neurotransmitter:sodium symporter activity
MLG_RS14415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MLG_RS14420	COG1333	cytochrome c biogenesis protein
MLG_RS14435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MLG_RS14440	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
MLG_RS14445	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MLG_RS14455	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MLG_RS14475	COG0210	DNA helicase
MLG_RS14480	COG0583	DNA-binding transcription factor activity
MLG_RS14495	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MLG_RS14500	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MLG_RS14505	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MLG_RS14510	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MLG_RS14515	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MLG_RS14520	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MLG_RS14525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MLG_RS14535	COG0356	it plays a direct role in the translocation of protons across the membrane
MLG_RS14545	COG1475	DNA binding
MLG_RS14550	COG1192	Involved in chromosome partitioning
MLG_RS14555	COG0357	Ribosomal RNA small subunit methyltransferase G
MLG_RS14560	COG0445	tRNA wobble uridine modification
MLG_RS14565	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MLG_RS14570	COG0706	membrane insertase activity
MLG_RS14575	COG0594	ribonuclease P activity
MLG_RS14580	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MLG_RS14635	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MLG_RS14650	COG0330	HflC and HflK could
MLG_RS14655	COG1372	Participates in initiation and elongation during chromosome replication
MLG_RS14655	COG0305	Participates in initiation and elongation during chromosome replication
MLG_RS14680	COG3300	MHYT domain
MLG_RS14680	COG5001	Diguanylate cyclase
MLG_RS14685	COG3115	cell septum assembly
MLG_RS14690	COG3706	GGDEF domain
MLG_RS14720	COG4970	Tfp pilus assembly protein FimT
MLG_RS14765	COG3290	protein histidine kinase activity
MLG_RS14775	COG3706	GGDEF domain
MLG_RS14810	COG1530	ribonuclease E activity
MLG_RS14815	COG2885	chlorophyll binding
MLG_RS14815	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MLG_RS14855	COG0745	RESPONSE REGULATOR receiver
MLG_RS14860	COG5002	protein histidine kinase activity
MLG_RS14865	COG4191	Histidine kinase
MLG_RS14875	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MLG_RS14905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MLG_RS14910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MLG_RS14945	COG0425	Belongs to the sulfur carrier protein TusA family
MLG_RS14960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes