locus-tag	class	description
MY523_RS00010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MY523_RS00020	COG1355	regulation of microtubule-based process
MY523_RS00025	COG2078	PFAM AMMECR1 domain protein
MY523_RS00025	COG3885	ferrous iron binding
MY523_RS00035	COG0142	geranyltranstransferase activity
MY523_RS00040	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MY523_RS00050	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MY523_RS00055	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MY523_RS00060	COG0268	Binds directly to 16S ribosomal RNA
MY523_RS00065	COG0728	peptidoglycan biosynthetic process
MY523_RS00070	COG0196	riboflavin kinase activity
MY523_RS00075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MY523_RS00085	COG1047	Peptidyl-prolyl cis-trans
MY523_RS00090	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MY523_RS00135	COG4969	Belongs to the N-Me-Phe pilin family
MY523_RS00140	COG4968	Prepilin-type N-terminal cleavage methylation domain
MY523_RS00160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MY523_RS00160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MY523_RS00195	COG0028	Belongs to the TPP enzyme family
MY523_RS00210	COG1183	phosphatidylcholine synthase activity
MY523_RS00220	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
MY523_RS00245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MY523_RS00255	COG0456	acetyltransferase
MY523_RS00260	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
MY523_RS00265	COG4191	Histidine kinase
MY523_RS00270	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MY523_RS00275	COG0084	hydrolase, TatD family'
MY523_RS00280	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MY523_RS00285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MY523_RS00290	COG0723	plastoquinol--plastocyanin reductase activity
MY523_RS00295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MY523_RS00300	COG2857	Cytochrome c1
MY523_RS00305	COG0625	glutathione transferase activity
MY523_RS00310	COG2969	positive regulation of protein catabolic process
MY523_RS00315	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MY523_RS00320	COG0792	nuclease activity
MY523_RS00325	COG3107	peptidoglycan biosynthetic process
MY523_RS00330	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MY523_RS00340	COG2001	Belongs to the MraZ family
MY523_RS00345	COG0275	rRNA processing
MY523_RS00360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MY523_RS00365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MY523_RS00370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MY523_RS00375	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MY523_RS00380	COG0772	Belongs to the SEDS family
MY523_RS00385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MY523_RS00390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MY523_RS00395	COG1181	Belongs to the D-alanine--D-alanine ligase family
MY523_RS00400	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MY523_RS00415	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MY523_RS00425	COG0739	heme binding
MY523_RS00430	COG0653	protein targeting
MY523_RS00435	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MY523_RS00440	COG0352	thiamine-phosphate diphosphorylase activity
MY523_RS00445	COG0315	cyclic pyranopterin monophosphate synthase activity
MY523_RS00450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MY523_RS00455	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MY523_RS00460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MY523_RS00465	COG0142	geranyltranstransferase activity
MY523_RS00475	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MY523_RS00495	COG0730	response to heat
MY523_RS00500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MY523_RS00505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MY523_RS00510	COG0840	transmembrane signaling receptor activity
MY523_RS00510	COG0840	transmembrane signaling receptor activity
MY523_RS00515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MY523_RS00520	COG0129	dihydroxy-acid dehydratase activity
MY523_RS00530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MY523_RS00545	COG0586	Pfam SNARE associated Golgi protein
MY523_RS00550	COG3706	GGDEF domain
MY523_RS00560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MY523_RS00565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MY523_RS00575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MY523_RS00580	COG0768	penicillin binding
MY523_RS00585	COG0772	Belongs to the SEDS family
MY523_RS00590	COG2951	lytic endotransglycosylase activity
MY523_RS00595	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MY523_RS00600	COG1686	Belongs to the peptidase S11 family
MY523_RS00610	COG2921	Belongs to the UPF0250 family
MY523_RS00635	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MY523_RS00645	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MY523_RS00675	COG0217	transcriptional regulatory protein
MY523_RS00680	COG1187	pseudouridine synthase activity
MY523_RS00720	COG0346	lactoylglutathione lyase activity
MY523_RS00725	COG0243	molybdopterin cofactor binding
MY523_RS00735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MY523_RS00740	COG2223	nitrite transmembrane transporter activity
MY523_RS00745	COG2223	nitrite transmembrane transporter activity
MY523_RS00750	COG2815	serine threonine protein kinase
MY523_RS00750	COG0515	serine threonine protein kinase
MY523_RS00755	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MY523_RS00820	COG4372	Transposase
MY523_RS00860	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MY523_RS00865	COG0583	DNA-binding transcription factor activity
MY523_RS00870	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MY523_RS00905	COG0427	acetyl-CoA hydrolase
MY523_RS00910	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MY523_RS00925	COG1136	(ABC) transporter
MY523_RS00925	COG0577	efflux transmembrane transporter activity
MY523_RS00940	COG4753	response regulator
MY523_RS00940	COG2207	Transcriptional regulator
MY523_RS00965	COG0243	molybdopterin cofactor binding
MY523_RS00970	COG0437	4 iron, 4 sulfur cluster binding
MY523_RS00985	COG3609	addiction module antidote protein, CC2985 family
MY523_RS01005	COG0523	cobalamin synthesis protein
MY523_RS01050	COG0028	Belongs to the TPP enzyme family
MY523_RS01075	COG0789	Transcriptional regulator
MY523_RS01075	COG4978	Transcriptional regulator
MY523_RS01080	COG0500	methyltransferase
MY523_RS01125	COG1309	transcriptional regulator
MY523_RS01130	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MY523_RS01145	COG0583	DNA-binding transcription factor activity
MY523_RS01160	COG0205	6-phosphofructokinase activity
MY523_RS01185	COG2166	iron-sulfur cluster assembly
MY523_RS01200	COG0316	Belongs to the HesB IscA family
MY523_RS01210	COG0719	Fe-S assembly protein
MY523_RS01215	COG0396	ATPase activity
MY523_RS01220	COG0719	Fe-S assembly protein
MY523_RS01240	COG2719	SpoVR family
MY523_RS01245	COG2718	Belongs to the UPF0229 family
MY523_RS01250	COG2766	serine protein kinase
MY523_RS01255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MY523_RS01260	COG0432	Pfam Uncharacterised protein family UPF0047
MY523_RS01265	COG2205	protein histidine kinase activity
MY523_RS01265	COG0784	Response regulator, receiver
MY523_RS01265	COG5002	protein histidine kinase activity
MY523_RS01280	COG4399	Belongs to the UPF0754 family
MY523_RS01290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MY523_RS01295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MY523_RS01300	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MY523_RS01305	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MY523_RS01310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MY523_RS01320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MY523_RS01325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MY523_RS01330	COG0126	phosphoglycerate kinase activity
MY523_RS01335	COG0191	fructose-bisphosphate aldolase activity
MY523_RS01345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MY523_RS01355	COG0513	Belongs to the DEAD box helicase family
MY523_RS01385	COG2885	chlorophyll binding
MY523_RS01390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MY523_RS01395	COG0277	FAD linked oxidase domain protein
MY523_RS01400	COG0179	Fumarylacetoacetate (FAA) hydrolase
MY523_RS01415	COG1187	pseudouridine synthase activity
MY523_RS01420	COG1285	pathogenesis
MY523_RS01450	COG0189	ligase activity
MY523_RS01460	COG3264	Mechanosensitive ion channel
MY523_RS01460	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MY523_RS01465	COG0598	Magnesium transport protein CorA
MY523_RS01475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MY523_RS01480	COG2252	PERMEase
MY523_RS01495	COG0189	ligase activity
MY523_RS01495	COG4067	protein conserved in archaea
MY523_RS01505	COG0189	ligase activity
MY523_RS01515	COG0583	DNA-binding transcription factor activity
MY523_RS01545	COG1028	Short-chain dehydrogenase reductase Sdr
MY523_RS01555	COG1024	Enoyl-CoA hydratase
MY523_RS01565	COG1960	acyl-CoA dehydrogenase activity
MY523_RS01570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MY523_RS01575	COG1028	Short-chain dehydrogenase reductase Sdr
MY523_RS01585	COG1309	transcriptional regulator
MY523_RS01645	COG1401	restriction endodeoxyribonuclease activity
MY523_RS01650	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MY523_RS01660	COG0732	type I restriction modification DNA specificity domain
MY523_RS01665	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MY523_RS01685	COG3609	addiction module antidote protein, CC2985 family
MY523_RS01725	COG0439	Biotin carboxylase
MY523_RS01745	COG1132	(ABC) transporter
MY523_RS01800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MY523_RS01835	COG0419	ATPase involved in DNA repair
MY523_RS01840	COG0420	3'-5' exonuclease activity
MY523_RS01845	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MY523_RS01855	COG1012	belongs to the aldehyde dehydrogenase family
MY523_RS01875	COG4175	Glycine betaine
MY523_RS01890	COG0493	'glutamate synthase
MY523_RS01900	COG1061	Type III restriction enzyme res subunit
MY523_RS01905	COG0204	Acyl-transferase
MY523_RS01910	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
MY523_RS01930	COG0513	Belongs to the DEAD box helicase family
MY523_RS01935	COG1187	pseudouridine synthase activity
MY523_RS02015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MY523_RS02025	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MY523_RS02030	COG0347	Belongs to the P(II) protein family
MY523_RS02040	COG0789	Transcriptional regulator
MY523_RS02045	COG2217	Heavy metal translocating P-type atpase
MY523_RS02080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MY523_RS02095	COG1136	(ABC) transporter
MY523_RS02100	COG0577	efflux transmembrane transporter activity
MY523_RS02115	COG2132	Multicopper oxidase
MY523_RS02165	COG1231	oxidoreductase activity
MY523_RS02170	COG0484	heat shock protein binding
MY523_RS02175	COG0789	Transcriptional regulator
MY523_RS02180	COG1280	lysine exporter protein (LysE YggA)
MY523_RS02190	COG0791	NLP P60 protein
MY523_RS02230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MY523_RS02310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MY523_RS02325	COG0840	transmembrane signaling receptor activity
MY523_RS02340	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MY523_RS02360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MY523_RS02365	COG0488	(ABC) transporter
MY523_RS02400	COG0417	DNA replication proofreading
MY523_RS02410	COG3228	Belongs to the MtfA family
MY523_RS02425	COG3850	Histidine kinase
MY523_RS02425	COG4999	Histidine kinase
MY523_RS02425	COG2205	protein histidine kinase activity
MY523_RS02425	COG3437	response regulator, receiver
MY523_RS02460	COG2816	NAD+ diphosphatase activity
MY523_RS02465	COG3588	fructose-bisphosphate aldolase
MY523_RS02470	COG1022	Amp-dependent synthetase and ligase
MY523_RS02475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MY523_RS02480	COG3091	SprT-like family
MY523_RS02500	COG2199	diguanylate cyclase activity
MY523_RS02500	COG2200	EAL domain
MY523_RS02505	COG3038	cytochrome b561
MY523_RS02510	COG2353	YceI-like domain
MY523_RS02550	COG0745	RESPONSE REGULATOR receiver
MY523_RS02555	COG2205	protein histidine kinase activity
MY523_RS02570	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MY523_RS02575	COG3842	ATPase activity
MY523_RS02580	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MY523_RS02585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MY523_RS02595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MY523_RS02610	COG4536	flavin adenine dinucleotide binding
MY523_RS02615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MY523_RS02620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MY523_RS02625	COG0228	four-way junction DNA binding
MY523_RS02630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MY523_RS02640	COG0335	large ribosomal subunit rRNA binding
MY523_RS02645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MY523_RS02650	COG0436	Aminotransferase
MY523_RS02665	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MY523_RS02670	COG0824	Thioesterase
MY523_RS02680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MY523_RS02685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MY523_RS02690	COG1639	'signal transduction protein
MY523_RS02735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MY523_RS02755	COG0481	GTPase activity
MY523_RS02760	COG0681	Belongs to the peptidase S26 family
MY523_RS02770	COG0571	ribonuclease III activity
MY523_RS02780	COG1381	Involved in DNA repair and RecF pathway recombination
MY523_RS02785	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MY523_RS02790	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MY523_RS02795	COG0154	amidase activity
MY523_RS02800	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MY523_RS02805	COG1077	Cell shape determining protein MreB Mrl
MY523_RS02810	COG1792	Involved in formation and maintenance of cell shape
MY523_RS02815	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MY523_RS02820	COG0424	maF-like protein
MY523_RS02825	COG1530	ribonuclease E activity
MY523_RS02835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MY523_RS02840	COG3028	Belongs to the UPF0307 family
MY523_RS02845	COG2239	Acts as a magnesium transporter
MY523_RS02850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MY523_RS02855	COG1660	Displays ATPase and GTPase activities
MY523_RS02875	COG1137	ATPase activity
MY523_RS02900	COG1127	ABC transporter
MY523_RS02905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MY523_RS02910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MY523_RS02925	COG5007	Belongs to the BolA IbaG family
MY523_RS02930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MY523_RS02935	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MY523_RS02945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MY523_RS02955	COG3105	Protein conserved in bacteria
MY523_RS02960	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MY523_RS02970	COG0183	Belongs to the thiolase family
MY523_RS02985	COG2197	response regulator
MY523_RS03020	COG0640	Transcriptional regulator
MY523_RS03030	COG5002	protein histidine kinase activity
MY523_RS03030	COG2205	protein histidine kinase activity
MY523_RS03030	COG0784	Response regulator, receiver
MY523_RS03045	COG1720	tRNA m6t6A37 methyltransferase activity
MY523_RS03050	COG1346	cytolysis
MY523_RS03055	COG1380	Effector of murein hydrolase LrgA
MY523_RS03065	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MY523_RS03070	COG0237	dephospho-CoA kinase activity
MY523_RS03105	COG0463	Glycosyl transferase, family 2
MY523_RS03110	COG0438	transferase activity, transferring glycosyl groups
MY523_RS03115	COG0367	asparagine synthase
MY523_RS03125	COG2089	acid synthase
MY523_RS03130	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MY523_RS03140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MY523_RS03175	COG2226	methyltransferase
MY523_RS03195	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MY523_RS03200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MY523_RS03210	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MY523_RS03230	COG1088	dTDP-glucose 4,6-dehydratase activity
MY523_RS03245	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MY523_RS03270	COG0529	Catalyzes the synthesis of activated sulfate
MY523_RS03275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MY523_RS03295	COG2165	general secretion pathway protein
MY523_RS03325	COG1450	Type ii and iii secretion system protein
MY523_RS03335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MY523_RS03365	COG1216	Glycosyl transferase, family 2
MY523_RS03365	COG0438	transferase activity, transferring glycosyl groups
MY523_RS03410	COG1086	Polysaccharide biosynthesis protein
MY523_RS03435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MY523_RS03445	COG0662	Cupin 2, conserved barrel domain protein
MY523_RS03445	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MY523_RS03455	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
MY523_RS03500	COG2900	Belongs to the SlyX family
MY523_RS03520	COG2226	methyltransferase
MY523_RS03525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MY523_RS03530	COG2171	N-acyltransferase activity
MY523_RS03535	COG1393	Belongs to the ArsC family
MY523_RS03540	COG0436	Aminotransferase
MY523_RS03545	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MY523_RS03550	COG0024	Methionine aminopeptidase
MY523_RS03555	COG0052	Belongs to the universal ribosomal protein uS2 family
MY523_RS03560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MY523_RS03565	COG0528	UMP kinase activity
MY523_RS03570	COG0233	cytoplasmic translational termination
MY523_RS03585	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MY523_RS03595	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MY523_RS03605	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MY523_RS03610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MY523_RS03615	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MY523_RS03620	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MY523_RS03635	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MY523_RS03640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MY523_RS03645	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MY523_RS03660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MY523_RS03670	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MY523_RS03675	COG0439	Biotin carboxylase
MY523_RS03680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MY523_RS03695	COG3154	lipid carrier protein
MY523_RS03700	COG1242	4 iron, 4 sulfur cluster binding
MY523_RS03705	COG0826	peptidase U32
MY523_RS03710	COG0826	peptidase U32
MY523_RS03725	COG1203	CRISPR-associated helicase, Cas3
MY523_RS03760	COG1518	maintenance of DNA repeat elements
MY523_RS03765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MY523_RS03780	COG1067	ATP-dependent peptidase activity
MY523_RS03800	COG4566	intracellular signal transduction
MY523_RS03805	COG4191	Histidine kinase
MY523_RS03815	COG2962	Rard protein
MY523_RS03820	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MY523_RS03850	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MY523_RS03855	COG0372	Belongs to the citrate synthase family
MY523_RS03860	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MY523_RS03875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MY523_RS03875	COG3153	acetyltransferase
MY523_RS03880	COG2133	pyrroloquinoline quinone binding
MY523_RS03890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MY523_RS03900	COG1028	Short-chain dehydrogenase reductase Sdr
MY523_RS03940	COG4771	TonB-dependent receptor
MY523_RS03945	COG0222	ribosome binding
MY523_RS03955	COG0596	Alpha beta hydrolase
MY523_RS03955	COG0508	dehydrogenase complex catalyzes the overall conversion of
MY523_RS03960	COG1309	transcriptional regulator
MY523_RS03970	COG2738	Putative neutral zinc metallopeptidase
MY523_RS04020	COG2161	toxin-antitoxin pair type II binding
MY523_RS04025	COG4115	mRNA cleavage
MY523_RS04105	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MY523_RS04115	COG0563	adenylate kinase activity
MY523_RS04120	COG1214	PFAM Peptidase M22, glycoprotease
MY523_RS04125	COG1968	undecaprenyl-diphosphatase activity
MY523_RS04135	COG0742	ribosomal rna small subunit methyltransferase
MY523_RS04140	COG2937	Belongs to the GPAT DAPAT family
MY523_RS04145	COG1131	(ABC) transporter
MY523_RS04160	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MY523_RS04185	COG4191	Histidine kinase
MY523_RS04210	COG1120	ATPase activity
MY523_RS04215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MY523_RS04220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MY523_RS04225	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MY523_RS04250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MY523_RS04265	COG0583	DNA-binding transcription factor activity
MY523_RS04270	COG1960	acyl-CoA dehydrogenase activity
MY523_RS04275	COG1028	Short-chain dehydrogenase reductase Sdr
MY523_RS04290	COG1028	Short-chain dehydrogenase reductase Sdr
MY523_RS04300	COG2200	EAL domain
MY523_RS04300	COG2199	diguanylate cyclase activity
MY523_RS04305	COG1785	Belongs to the alkaline phosphatase family
MY523_RS04320	COG1573	uracil-dna glycosylase
MY523_RS04330	COG1785	Belongs to the alkaline phosphatase family
MY523_RS04350	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
MY523_RS04355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MY523_RS04385	COG0204	Acyl-transferase
MY523_RS04410	COG2259	Doxx family
MY523_RS04430	COG0469	pyruvate kinase activity
MY523_RS04435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MY523_RS04440	COG2996	Protein conserved in bacteria
MY523_RS04455	COG0668	transmembrane transport
MY523_RS04460	COG1643	Atp-dependent helicase
MY523_RS04470	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MY523_RS04475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MY523_RS04495	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MY523_RS04515	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MY523_RS04555	COG1940	carbohydrate kinase activity
MY523_RS04570	COG0525	valine-tRNA ligase activity
MY523_RS04585	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MY523_RS04590	COG0795	lipopolysaccharide-transporting ATPase activity
MY523_RS04595	COG0795	lipopolysaccharide-transporting ATPase activity
MY523_RS04615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MY523_RS04625	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MY523_RS04645	COG3630	sodium ion export across plasma membrane
MY523_RS04650	COG0511	ligase activity, forming carbon-carbon bonds
MY523_RS04650	COG5016	pyruvate
MY523_RS04655	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MY523_RS04685	COG1677	Flagellar hook-basal body complex protein FliE
MY523_RS04720	COG0745	RESPONSE REGULATOR receiver
MY523_RS04725	COG2198	Histidine kinase
MY523_RS04725	COG0643	Histidine kinase
MY523_RS04730	COG0835	chemotaxis
MY523_RS04740	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MY523_RS04745	COG2201	protein-glutamate methylesterase activity
MY523_RS04785	COG3190	flagellar
MY523_RS04795	COG1987	bacterial-type flagellum assembly
MY523_RS04835	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MY523_RS04840	COG0643	Histidine kinase
MY523_RS04840	COG0784	Response regulator, receiver
MY523_RS04840	COG2198	Histidine kinase
MY523_RS04845	COG2201	protein-glutamate methylesterase activity
MY523_RS04850	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MY523_RS04860	COG1192	Involved in chromosome partitioning
MY523_RS04875	COG0835	chemotaxis
MY523_RS04885	COG2257	FlhB HrpN YscU SpaS Family
MY523_RS04895	COG4133	protoheme IX ABC transporter activity
MY523_RS04915	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MY523_RS04920	COG1138	Cytochrome C-type biogenesis protein
MY523_RS04940	COG1028	Short-chain dehydrogenase reductase Sdr
MY523_RS04945	COG0546	phosphoglycolate phosphatase activity
MY523_RS04950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MY523_RS04955	COG0402	S-adenosylhomocysteine deaminase activity
MY523_RS04960	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MY523_RS04980	COG1024	Enoyl-CoA hydratase
MY523_RS04980	COG1250	3-hydroxyacyl-CoA dehydrogenase
MY523_RS04985	COG0183	Belongs to the thiolase family
MY523_RS05005	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MY523_RS05010	COG0047	phosphoribosylformylglycinamidine synthase activity
MY523_RS05010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MY523_RS05030	COG3313	Fe-S protein
MY523_RS05035	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MY523_RS05070	COG2925	Exonuclease
MY523_RS05085	COG1028	Short-chain dehydrogenase reductase Sdr
MY523_RS05100	COG0631	protein serine/threonine phosphatase activity
MY523_RS05125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MY523_RS05140	COG2204	response regulator
MY523_RS05155	COG0778	Nitroreductase
MY523_RS05160	COG2015	COG2015, Alkyl sulfatase and related hydrolases
MY523_RS05165	COG0653	protein targeting
MY523_RS05170	COG0515	serine threonine protein kinase
MY523_RS05185	COG0450	alkyl hydroperoxide reductase
MY523_RS05190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MY523_RS05195	COG0418	dihydroorotase activity
MY523_RS05205	COG0137	argininosuccinate synthase activity
MY523_RS05215	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MY523_RS05225	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MY523_RS05225	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
MY523_RS05240	COG2154	pterin-4-alpha-carbinolamine dehydratase
MY523_RS05245	COG0788	formyltetrahydrofolate deformylase activity
MY523_RS05260	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MY523_RS05265	COG0077	Prephenate dehydratase
MY523_RS05265	COG1605	Chorismate mutase
MY523_RS05270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MY523_RS05275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MY523_RS05280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MY523_RS05290	COG0776	regulation of translation
MY523_RS05300	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MY523_RS05305	COG0284	orotidine-5'-phosphate decarboxylase activity
MY523_RS05315	COG0436	Aminotransferase
MY523_RS05320	COG0556	nucleotide-excision repair
MY523_RS05325	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MY523_RS05335	COG0167	dihydroorotate dehydrogenase activity
MY523_RS05340	COG3130	regulation of translation
MY523_RS05345	COG0116	Belongs to the methyltransferase superfamily
MY523_RS05345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MY523_RS05370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MY523_RS05375	COG1362	aminopeptidase activity
MY523_RS05395	COG0429	hydrolase of the alpha beta-hydrolase fold
MY523_RS05405	COG4181	ATPase activity
MY523_RS05410	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MY523_RS05440	COG1024	Enoyl-CoA hydratase
MY523_RS05465	COG4974	Belongs to the 'phage' integrase family
MY523_RS05470	COG0517	IMP dehydrogenase activity
MY523_RS05485	COG3344	reverse transcriptase
MY523_RS05525	COG3547	Transposase (IS116 IS110 IS902 family)
MY523_RS05565	COG0326	Molecular chaperone. Has ATPase activity
MY523_RS05595	COG3177	Filamentation induced by cAMP protein fic
MY523_RS05600	COG2837	iron assimilation
MY523_RS05605	COG3706	GGDEF domain
MY523_RS05610	COG2201	protein-glutamate methylesterase activity
MY523_RS05645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MY523_RS05660	COG0023	Translation Initiation Factor
MY523_RS05665	COG5265	(ABC) transporter
MY523_RS05670	COG2824	Alkylphosphonate utilization operon protein PhnA
MY523_RS05675	COG1360	Flagellar Motor Protein
MY523_RS05685	COG2226	methyltransferase
MY523_RS05690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MY523_RS05700	COG2814	Major facilitator Superfamily
MY523_RS05705	COG3012	SEC-C Motif Domain Protein
MY523_RS05710	COG0778	Nitroreductase
MY523_RS05715	COG0596	Alpha beta hydrolase
MY523_RS05720	COG2081	HI0933 family
MY523_RS05755	COG3106	COG3106 Predicted ATPase
MY523_RS05760	COG3768	UPF0283 membrane protein
MY523_RS05780	COG0789	Transcriptional regulator
MY523_RS05790	COG4067	protein conserved in archaea
MY523_RS05790	COG0189	ligase activity
MY523_RS05800	COG0189	ligase activity
MY523_RS05820	COG1278	Cold shock
MY523_RS05870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MY523_RS05875	COG0564	pseudouridine synthase activity
MY523_RS05880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MY523_RS05885	COG0564	pseudouridine synthase activity
MY523_RS05905	COG2813	Specifically methylates the guanine in position
MY523_RS05915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MY523_RS05920	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MY523_RS05925	COG1607	acyl-coa hydrolase
MY523_RS05930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MY523_RS05965	COG0829	nickel cation binding
MY523_RS05970	COG0831	urea catabolic process
MY523_RS05975	COG0832	Belongs to the urease beta subunit family
MY523_RS05980	COG0804	urea catabolic process
MY523_RS05990	COG0830	nickel cation binding
MY523_RS05995	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MY523_RS06015	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
MY523_RS06020	COG2813	Specifically methylates the guanine in position
MY523_RS06025	COG0307	riboflavin synthase, alpha
MY523_RS06035	COG0617	tRNA 3'-terminal CCA addition
MY523_RS06035	COG0517	IMP dehydrogenase activity
MY523_RS06035	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MY523_RS06045	COG0004	ammonium transporteR
MY523_RS06060	COG1472	Belongs to the glycosyl hydrolase 3 family
MY523_RS06065	COG0668	transmembrane transport
MY523_RS06070	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MY523_RS06085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MY523_RS06095	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MY523_RS06100	COG1805	sodium ion transport
MY523_RS06115	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MY523_RS06120	COG2871	sodium ion transport
MY523_RS06125	COG1477	protein flavinylation
MY523_RS06130	COG2991	Protein conserved in bacteria
MY523_RS06135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MY523_RS06140	COG0584	glycerophosphoryl diester phosphodiesterase
MY523_RS06150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MY523_RS06155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MY523_RS06170	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
MY523_RS06175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MY523_RS06180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MY523_RS06215	COG0574	Belongs to the PEP-utilizing enzyme family
MY523_RS06215	COG3848	Pyruvate phosphate dikinase
MY523_RS06225	COG0318	PFAM AMP-dependent synthetase and ligase
MY523_RS06260	COG1803	Methylglyoxal synthase
MY523_RS06270	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MY523_RS06285	COG0702	epimerase
MY523_RS06290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MY523_RS06305	COG2350	Protein conserved in bacteria
MY523_RS06310	COG0613	PHP domain protein
MY523_RS06320	COG1530	ribonuclease E activity
MY523_RS06325	COG0564	pseudouridine synthase activity
MY523_RS06345	COG1399	metal-binding, possibly nucleic acid-binding protein
MY523_RS06350	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MY523_RS06355	COG0416	fatty acid biosynthetic process
MY523_RS06360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MY523_RS06370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MY523_RS06375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MY523_RS06380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MY523_RS06385	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MY523_RS06390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MY523_RS06395	COG0501	Belongs to the peptidase M48B family
MY523_RS06405	COG0604	alcohol dehydrogenase
MY523_RS06410	COG1703	isobutyryl-CoA mutase activity
MY523_RS06415	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MY523_RS06415	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MY523_RS06425	COG3321	synthase
MY523_RS06425	COG0604	alcohol dehydrogenase
MY523_RS06425	COG1028	Short-chain dehydrogenase reductase Sdr
MY523_RS06430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MY523_RS06435	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
MY523_RS06445	COG0604	alcohol dehydrogenase
MY523_RS06445	COG1028	Short-chain dehydrogenase reductase Sdr
MY523_RS06445	COG3321	synthase
MY523_RS06455	COG2239	Acts as a magnesium transporter
MY523_RS06470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MY523_RS06480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MY523_RS06485	COG0215	cysteine-tRNA ligase activity
MY523_RS06490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MY523_RS06515	COG0544	peptidyl-prolyl cis-trans isomerase activity
MY523_RS06520	COG0740	serine-type endopeptidase activity
MY523_RS06525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MY523_RS06530	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MY523_RS06540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MY523_RS06565	COG0726	polysaccharide deacetylase
MY523_RS06570	COG0484	heat shock protein binding
MY523_RS06580	COG1309	transcriptional regulator
MY523_RS06585	COG0037	tRNA processing
MY523_RS06600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MY523_RS06630	COG0348	domain, Protein
MY523_RS06635	COG2010	Cytochrome c
MY523_RS06650	COG3278	Belongs to the heme-copper respiratory oxidase family
MY523_RS06655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MY523_RS06660	COG0840	transmembrane signaling receptor activity
MY523_RS06665	COG2203	Gaf domain
MY523_RS06665	COG3706	GGDEF domain
MY523_RS06665	COG4251	negative regulation of phosphorylation
MY523_RS06665	COG5001	Diguanylate cyclase
MY523_RS06690	COG3101	peptidyl-lysine hydroxylation
MY523_RS06700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MY523_RS06715	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MY523_RS06725	COG0436	Aminotransferase
MY523_RS06735	COG1082	Xylose isomerase domain protein TIM barrel
MY523_RS06785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MY523_RS06800	COG1166	arginine decarboxylase activity
MY523_RS06815	COG0386	Belongs to the glutathione peroxidase family
MY523_RS06820	COG1846	Transcriptional regulator
MY523_RS06835	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MY523_RS06840	COG1074	ATP-dependent DNA helicase activity
MY523_RS06845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MY523_RS06865	COG0745	RESPONSE REGULATOR receiver
MY523_RS06880	COG1999	signal sequence binding
MY523_RS06910	COG0659	secondary active sulfate transmembrane transporter activity
MY523_RS06940	COG0583	DNA-binding transcription factor activity
MY523_RS06945	COG1960	acyl-CoA dehydrogenase activity
MY523_RS06950	COG0022	dehydrogenase e1 component
MY523_RS07035	COG4372	Transposase
MY523_RS07130	COG1012	belongs to the aldehyde dehydrogenase family
MY523_RS07140	COG1121	(ABC) transporter
MY523_RS07145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MY523_RS07160	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
MY523_RS07165	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MY523_RS07185	COG0730	response to heat
MY523_RS07200	COG0583	DNA-binding transcription factor activity
MY523_RS07260	COG1595	DNA-templated transcription, initiation
MY523_RS07270	COG0674	pyruvate-flavodoxin oxidoreductase activity
MY523_RS07270	COG1013	pyruvate-flavodoxin oxidoreductase activity
MY523_RS07270	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MY523_RS07270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MY523_RS07280	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MY523_RS07285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MY523_RS07285	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MY523_RS07290	COG0529	Catalyzes the synthesis of activated sulfate
MY523_RS07295	COG0471	metal ion transport
MY523_RS07295	COG3273	potassium ion transport
MY523_RS07300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MY523_RS07325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MY523_RS07330	COG1587	Uroporphyrinogen-III synthase
MY523_RS07340	COG0438	transferase activity, transferring glycosyl groups
MY523_RS07370	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MY523_RS07380	COG2244	polysaccharide biosynthetic process
MY523_RS07400	COG0463	Glycosyl transferase, family 2
MY523_RS07430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MY523_RS07455	COG0489	protein tyrosine kinase activity
MY523_RS07460	COG3267	Type II secretory pathway component ExeA
MY523_RS07460	COG3409	Peptidoglycan-binding domain 1 protein
MY523_RS07535	COG1960	acyl-CoA dehydrogenase activity
MY523_RS07540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MY523_RS07545	COG1024	Enoyl-CoA hydratase
MY523_RS07550	COG4770	biotin carboxylase activity
MY523_RS07560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MY523_RS07595	COG2188	Transcriptional regulator
MY523_RS07600	COG1840	ABC-type Fe3 transport system, periplasmic component
MY523_RS07605	COG3842	ATPase activity
MY523_RS07615	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MY523_RS07620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MY523_RS07630	COG0560	Phosphoserine phosphatase
MY523_RS07645	COG2062	phosphohistidine phosphatase, SixA
MY523_RS07655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MY523_RS07675	COG0708	Exodeoxyribonuclease III
MY523_RS07680	COG1309	transcriptional regulator
MY523_RS07695	COG0204	Acyl-transferase
MY523_RS07710	COG4191	Histidine kinase
MY523_RS07715	COG2204	response regulator
MY523_RS07745	COG4974	Belongs to the 'phage' integrase family
MY523_RS07755	COG0800	Aldolase
MY523_RS07760	COG0129	dihydroxy-acid dehydratase activity
MY523_RS07765	COG0363	glucosamine-6-phosphate deaminase activity
MY523_RS07770	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MY523_RS07775	COG2116	formate transmembrane transporter activity
MY523_RS07780	COG0515	serine threonine protein kinase
MY523_RS07780	COG2815	serine threonine protein kinase
MY523_RS07785	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
MY523_RS07790	COG0071	Belongs to the small heat shock protein (HSP20) family
MY523_RS07800	COG0446	pyridine nucleotide-disulphide oxidoreductase
MY523_RS07800	COG1902	pentaerythritol trinitrate reductase activity
MY523_RS07810	COG0328	RNA-DNA hybrid ribonuclease activity
MY523_RS07830	COG0739	heme binding
MY523_RS07830	COG0741	lytic transglycosylase activity
MY523_RS07830	COG1196	nuclear chromosome segregation
MY523_RS07840	COG1960	acyl-CoA dehydrogenase activity
MY523_RS07860	COG1215	transferase activity, transferring glycosyl groups
MY523_RS07870	COG1216	Glycosyl transferase, family 2
MY523_RS07925	COG0463	Glycosyl transferase, family 2
MY523_RS07935	COG0438	transferase activity, transferring glycosyl groups
MY523_RS07940	COG0438	transferase activity, transferring glycosyl groups
MY523_RS07955	COG0463	Glycosyl transferase, family 2
MY523_RS07955	COG1216	Glycosyl transferase, family 2
MY523_RS07965	COG1215	transferase activity, transferring glycosyl groups
MY523_RS08000	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MY523_RS08005	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MY523_RS08015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MY523_RS08020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MY523_RS08025	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MY523_RS08030	COG2835	tetraacyldisaccharide 4'-kinase activity
MY523_RS08035	COG1663	tetraacyldisaccharide 4'-kinase activity
MY523_RS08040	COG1132	(ABC) transporter
MY523_RS08045	COG0848	biopolymer transport protein
MY523_RS08050	COG0811	peptide transport
MY523_RS08055	COG2333	competence protein COMEC
MY523_RS08055	COG0658	competence protein
MY523_RS08065	COG1136	(ABC) transporter
MY523_RS08070	COG4591	ABC-type transport system involved in lipoprotein release permease component
MY523_RS08085	COG2957	Belongs to the agmatine deiminase family
MY523_RS08095	COG0714	Associated with various cellular activities
MY523_RS08100	COG0492	ferredoxin-NADP+ reductase activity
MY523_RS08105	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MY523_RS08110	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MY523_RS08115	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MY523_RS08120	COG0542	response to heat
MY523_RS08125	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MY523_RS08145	COG0482	sulfurtransferase activity
MY523_RS08150	COG2915	High frequency lysogenization protein hflD homolog
MY523_RS08160	COG2850	peptidyl-arginine hydroxylation
MY523_RS08195	COG1979	alcohol dehydrogenase
MY523_RS08205	COG0583	DNA-binding transcription factor activity
MY523_RS08210	COG1169	isochorismate synthase
MY523_RS08215	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MY523_RS08225	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MY523_RS08230	COG1441	menaquinone biosynthetic process
MY523_RS08245	COG1451	nucleotide metabolic process
MY523_RS08280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MY523_RS08310	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MY523_RS08315	COG2923	Belongs to the DsrF TusC family
MY523_RS08330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MY523_RS08335	COG4399	Belongs to the UPF0754 family
MY523_RS08340	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MY523_RS08340	COG0316	Belongs to the HesB IscA family
MY523_RS08350	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MY523_RS08365	COG0616	signal peptide processing
MY523_RS08390	COG0328	RNA-DNA hybrid ribonuclease activity
MY523_RS08400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MY523_RS08405	COG0741	lytic transglycosylase activity
MY523_RS08405	COG1388	LysM domain
MY523_RS08415	COG4166	transmembrane transport
MY523_RS08420	COG4166	transmembrane transport
MY523_RS08425	COG4174	ABC transporter (Permease)
MY523_RS08430	COG4239	(ABC) transporter, permease
MY523_RS08435	COG4172	Belongs to the ABC transporter superfamily
MY523_RS08470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MY523_RS08470	COG1648	precorrin-2 dehydrogenase activity
MY523_RS08475	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MY523_RS08480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MY523_RS08485	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MY523_RS08490	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MY523_RS08495	COG1674	ftsk spoiiie
MY523_RS08510	COG1286	toxin biosynthetic process
MY523_RS08520	COG0285	dihydrofolate synthase activity
MY523_RS08525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MY523_RS08530	COG0159	tryptophan synthase activity
MY523_RS08540	COG0135	phosphoribosylanthranilate isomerase activity
MY523_RS08560	COG0473	3-isopropylmalate dehydrogenase activity
MY523_RS08565	COG0066	3-isopropylmalate dehydratase activity
MY523_RS08570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MY523_RS08580	COG3243	poly(R)-hydroxyalkanoic acid synthase
MY523_RS08595	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MY523_RS08620	COG0084	hydrolase, TatD family'
MY523_RS08700	COG0730	response to heat
MY523_RS08705	COG2909	trisaccharide binding
MY523_RS08710	COG1199	ATP-dependent helicase activity
MY523_RS08715	COG3266	domain, Protein
MY523_RS08730	COG2853	Lipoprotein
MY523_RS08740	COG1643	Atp-dependent helicase
MY523_RS08745	COG0318	PFAM AMP-dependent synthetase and ligase
MY523_RS08750	COG2267	carboxylic ester hydrolase activity
MY523_RS08755	COG2030	dehydratase
MY523_RS08775	COG0811	peptide transport
MY523_RS08810	COG0542	response to heat
MY523_RS08815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MY523_RS08820	COG0121	glutamine amidotransferase
MY523_RS08840	COG2983	Belongs to the UPF0260 family
MY523_RS08845	COG3100	YcgL domain-containing protein
MY523_RS08850	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MY523_RS08855	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MY523_RS08860	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MY523_RS08865	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MY523_RS08870	COG1294	oxidase, subunit
MY523_RS08875	COG1271	oxidase subunit
MY523_RS08880	COG3852	Histidine kinase
MY523_RS08885	COG2204	response regulator
MY523_RS08890	COG0667	Aldo Keto reductase
MY523_RS08900	COG1309	transcriptional regulator
MY523_RS08940	COG1733	regulation of RNA biosynthetic process
MY523_RS08945	COG2267	carboxylic ester hydrolase activity
MY523_RS08995	COG3436	PFAM IS66 Orf2 family protein
MY523_RS09005	COG1960	acyl-CoA dehydrogenase activity
MY523_RS09020	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MY523_RS09035	COG4221	oxidoreductase activity
MY523_RS09050	COG0415	Belongs to the DNA photolyase family
MY523_RS09055	COG1595	DNA-templated transcription, initiation
MY523_RS09065	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MY523_RS09070	COG0784	Response regulator, receiver
MY523_RS09070	COG0835	chemotaxis
MY523_RS09095	COG3706	GGDEF domain
MY523_RS09095	COG4251	negative regulation of phosphorylation
MY523_RS09095	COG5001	Diguanylate cyclase
MY523_RS09095	COG2203	Gaf domain
MY523_RS09105	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MY523_RS09105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MY523_RS09110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MY523_RS09115	COG3115	cell septum assembly
MY523_RS09140	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MY523_RS09150	COG0180	Tryptophanyl-tRNA synthetase
MY523_RS09155	COG3344	reverse transcriptase
MY523_RS09175	COG0045	succinate-CoA ligase (ADP-forming) activity
MY523_RS09200	COG1053	succinate dehydrogenase
MY523_RS09205	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MY523_RS09230	COG0183	Belongs to the thiolase family
MY523_RS09235	COG1250	3-hydroxyacyl-CoA dehydrogenase
MY523_RS09235	COG1024	Enoyl-CoA hydratase
MY523_RS09250	COG0589	response to stress
MY523_RS09260	COG0488	(ABC) transporter
MY523_RS09270	COG0633	Ferredoxin
MY523_RS09270	COG3217	Mosc domain protein beta barrel domain protein
MY523_RS09275	COG0784	Response regulator, receiver
MY523_RS09275	COG0835	chemotaxis
MY523_RS09305	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MY523_RS09315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MY523_RS09335	COG2976	Protein conserved in bacteria
MY523_RS09340	COG0124	histidyl-tRNA synthetase
MY523_RS09345	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MY523_RS09350	COG1426	Protein conserved in bacteria
MY523_RS09360	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MY523_RS09365	COG0105	UTP biosynthetic process
MY523_RS09370	COG1104	cysteine desulfurase activity
MY523_RS09395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MY523_RS09405	COG1862	Preprotein translocase
MY523_RS09410	COG0343	queuine tRNA-ribosyltransferase activity
MY523_RS09415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MY523_RS09445	COG1706	bacterial-type flagellum-dependent cell motility
MY523_RS09450	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MY523_RS09455	COG4786	Flagellar basal body rod
MY523_RS09460	COG4787	bacterial-type flagellum-dependent cell motility
MY523_RS09470	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MY523_RS09480	COG1815	bacterial-type flagellum-dependent cell motility
MY523_RS09500	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MY523_RS09500	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MY523_RS09505	COG0842	Transport permease protein
MY523_RS09510	COG1131	(ABC) transporter
MY523_RS09535	COG1840	ABC-type Fe3 transport system, periplasmic component
MY523_RS09540	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MY523_RS09560	COG4120	Belongs to the binding-protein-dependent transport system permease family
MY523_RS09570	COG0515	serine threonine protein kinase
MY523_RS09570	COG2815	serine threonine protein kinase
MY523_RS09575	COG0631	protein serine/threonine phosphatase activity
MY523_RS09610	COG0438	transferase activity, transferring glycosyl groups
MY523_RS09690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MY523_RS09700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MY523_RS09705	COG2716	regulation of RNA biosynthetic process
MY523_RS09710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MY523_RS09735	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MY523_RS09750	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
MY523_RS09760	COG0823	Involved in the tonB-independent uptake of proteins
MY523_RS09760	COG5616	cAMP biosynthetic process
MY523_RS09780	COG0824	Thioesterase
MY523_RS09785	COG2255	four-way junction helicase activity
MY523_RS09790	COG0632	four-way junction helicase activity
MY523_RS09795	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MY523_RS09800	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MY523_RS09810	COG2198	Histidine kinase
MY523_RS09810	COG0643	Histidine kinase
MY523_RS09840	COG0519	Catalyzes the synthesis of GMP from XMP
MY523_RS09840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MY523_RS09850	COG1570	exodeoxyribonuclease VII activity
MY523_RS09860	COG0442	prolyl-tRNA aminoacylation
MY523_RS09880	COG0714	Associated with various cellular activities
MY523_RS09900	COG2304	oxidoreductase activity
MY523_RS09920	COG3022	response to hydroperoxide
MY523_RS09930	COG2974	May be involved in recombination
MY523_RS09950	COG0045	succinate-CoA ligase (ADP-forming) activity
MY523_RS09950	COG1042	CoA-binding domain protein
MY523_RS09950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MY523_RS09955	COG0123	including yeast histone deacetylase and acetoin utilization protein
MY523_RS09965	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MY523_RS10010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MY523_RS10115	COG0009	L-threonylcarbamoyladenylate synthase
MY523_RS10120	COG0271	Belongs to the BolA IbaG family
MY523_RS10125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MY523_RS10140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MY523_RS10140	COG4191	Histidine kinase
MY523_RS10150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MY523_RS10160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MY523_RS10165	COG1028	Short-chain dehydrogenase reductase Sdr
MY523_RS10180	COG1639	'signal transduction protein
MY523_RS10185	COG1234	tRNA 3'-trailer cleavage
MY523_RS10220	COG2010	Cytochrome c
MY523_RS10225	COG2010	Cytochrome c
MY523_RS10260	COG2010	Cytochrome c
MY523_RS10290	COG0535	radical SAM domain protein
MY523_RS10295	COG1648	precorrin-2 dehydrogenase activity
MY523_RS10295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MY523_RS10315	COG0714	Associated with various cellular activities
MY523_RS10330	COG5002	protein histidine kinase activity
MY523_RS10330	COG5001	Diguanylate cyclase
MY523_RS10335	COG1322	Protein conserved in bacteria
MY523_RS10360	COG2199	diguanylate cyclase activity
MY523_RS10360	COG2203	Gaf domain
MY523_RS10415	COG0776	regulation of translation
MY523_RS10420	COG0072	phenylalanine-tRNA ligase activity
MY523_RS10420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MY523_RS10425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MY523_RS10430	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MY523_RS10435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MY523_RS10440	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MY523_RS10445	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MY523_RS10455	COG2358	TRAP transporter, solute receptor (TAXI family
MY523_RS10475	COG0308	aminopeptidase N
MY523_RS10490	COG0705	Rhomboid family
MY523_RS10495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MY523_RS10500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MY523_RS10510	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MY523_RS10575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MY523_RS10585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MY523_RS10595	COG1704	LemA family
MY523_RS10600	COG0501	Belongs to the peptidase M48B family
MY523_RS10620	COG0459	protein refolding
MY523_RS10625	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MY523_RS10630	COG3030	protein affecting phage T7 exclusion by the F plasmid
MY523_RS10635	COG1028	Short-chain dehydrogenase reductase Sdr
MY523_RS10645	COG2211	Major facilitator Superfamily
MY523_RS10650	COG1666	GTP binding
MY523_RS10655	COG0745	RESPONSE REGULATOR receiver
MY523_RS10660	COG1070	Carbohydrate kinase
MY523_RS10665	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MY523_RS10680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MY523_RS10685	COG2207	Transcriptional regulator
MY523_RS10690	COG3706	GGDEF domain
MY523_RS10780	COG1960	acyl-CoA dehydrogenase activity
MY523_RS10790	COG1054	Belongs to the UPF0176 family
MY523_RS10795	COG3706	GGDEF domain
MY523_RS10805	COG0534	Mate efflux family protein
MY523_RS10815	COG2226	methyltransferase
MY523_RS10825	COG1960	acyl-CoA dehydrogenase activity
MY523_RS10830	COG3977	Valine--pyruvate aminotransferase
MY523_RS10840	COG0235	Class ii aldolase
MY523_RS10845	COG2814	Major facilitator Superfamily
MY523_RS10850	COG0717	Belongs to the dCTP deaminase family
MY523_RS10855	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MY523_RS10870	COG1216	Glycosyl transferase, family 2
MY523_RS10870	COG1442	glycosyl transferase family 8
MY523_RS10875	COG1215	transferase activity, transferring glycosyl groups
MY523_RS10885	COG0438	transferase activity, transferring glycosyl groups
MY523_RS10885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MY523_RS10910	COG0726	polysaccharide deacetylase
MY523_RS10915	COG4619	ABC transporter
MY523_RS10920	COG0390	transport system, permease component
MY523_RS10935	COG0489	protein tyrosine kinase activity
MY523_RS10940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MY523_RS10940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MY523_RS10945	COG4657	Part of a membrane complex involved in electron transport
MY523_RS10950	COG2878	Part of a membrane complex involved in electron transport
MY523_RS10955	COG4656	Part of a membrane complex involved in electron transport
MY523_RS10960	COG4658	electron transport chain
MY523_RS10965	COG4659	FMN binding
MY523_RS10970	COG4660	Part of a membrane complex involved in electron transport
MY523_RS10975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MY523_RS10985	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MY523_RS11020	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MY523_RS11025	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MY523_RS11030	COG0585	pseudouridine synthase activity
MY523_RS11035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MY523_RS11040	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MY523_RS11045	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MY523_RS11050	COG0148	phosphopyruvate hydratase activity
MY523_RS11060	COG0504	CTP synthase activity
MY523_RS11065	COG0037	tRNA processing
MY523_RS11070	COG0825	malonyl-CoA metabolic process
MY523_RS11120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MY523_RS11125	COG1393	Belongs to the ArsC family
MY523_RS11140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MY523_RS11195	COG2885	chlorophyll binding
MY523_RS11225	COG0515	serine threonine protein kinase
MY523_RS11225	COG2815	serine threonine protein kinase
MY523_RS11230	COG0631	protein serine/threonine phosphatase activity
MY523_RS11260	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MY523_RS11270	COG2840	Smr protein MutS2
MY523_RS11275	COG0517	IMP dehydrogenase activity
MY523_RS11275	COG0516	GMP reductase activity
MY523_RS11280	COG2176	DNA-directed DNA polymerase activity
MY523_RS11290	COG3706	GGDEF domain
MY523_RS11295	COG2059	Chromate
MY523_RS11305	COG0517	IMP dehydrogenase activity
MY523_RS11310	COG2176	DNA-directed DNA polymerase activity
MY523_RS11315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MY523_RS11330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MY523_RS11340	COG2205	protein histidine kinase activity
MY523_RS11340	COG0784	Response regulator, receiver
MY523_RS11355	COG4251	negative regulation of phosphorylation
MY523_RS11360	COG0784	Response regulator, receiver
MY523_RS11365	COG5002	protein histidine kinase activity
MY523_RS11365	COG5001	Diguanylate cyclase
MY523_RS11405	COG0028	Belongs to the TPP enzyme family
MY523_RS11410	COG3956	TIGRFAM MazG family protein
MY523_RS11415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MY523_RS11420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MY523_RS11430	COG5002	protein histidine kinase activity
MY523_RS11430	COG0784	Response regulator, receiver
MY523_RS11430	COG2205	protein histidine kinase activity
MY523_RS11435	COG0784	Response regulator, receiver
MY523_RS11435	COG2205	protein histidine kinase activity
MY523_RS11435	COG5002	protein histidine kinase activity
MY523_RS11455	COG0175	sulfate reduction
MY523_RS11465	COG3081	Nucleoid-associated protein
MY523_RS11485	COG0366	Alpha amylase catalytic
MY523_RS11490	COG1215	transferase activity, transferring glycosyl groups
MY523_RS11495	COG3769	mannosylglycerate metabolic process
MY523_RS11510	COG0534	Mate efflux family protein
MY523_RS11515	COG2909	trisaccharide binding
MY523_RS11520	COG0513	Belongs to the DEAD box helicase family
MY523_RS11525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MY523_RS11530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MY523_RS11545	COG1702	phosphate starvation-inducible protein PhoH
MY523_RS11550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MY523_RS11555	COG4535	Mg2 and Co2 transporter CorC
MY523_RS11610	COG3344	reverse transcriptase
MY523_RS11645	COG0495	leucyl-tRNA aminoacylation
MY523_RS11650	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
MY523_RS11655	COG1466	dna polymerase III delta subunit
MY523_RS11670	COG1960	acyl-CoA dehydrogenase activity
MY523_RS11675	COG1960	acyl-CoA dehydrogenase activity
MY523_RS11690	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MY523_RS11700	COG2267	carboxylic ester hydrolase activity
MY523_RS11705	COG0156	8-amino-7-oxononanoate synthase activity
MY523_RS11710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MY523_RS11720	COG0716	FMN binding
MY523_RS11735	COG1120	ATPase activity
MY523_RS11740	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MY523_RS11750	COG4774	siderophore transport
MY523_RS11760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MY523_RS11765	COG1121	(ABC) transporter
MY523_RS11795	COG0811	peptide transport
MY523_RS11800	COG0811	peptide transport
MY523_RS11805	COG0848	biopolymer transport protein
MY523_RS11830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MY523_RS11835	COG1116	anion transmembrane transporter activity
MY523_RS11870	COG2193	ferroxidase activity
MY523_RS11880	COG2906	2 iron, 2 sulfur cluster binding
MY523_RS11885	COG1492	cobalamin metabolic process
MY523_RS11900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MY523_RS11910	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MY523_RS11915	COG2223	nitrite transmembrane transporter activity
MY523_RS11930	COG1960	acyl-CoA dehydrogenase activity
MY523_RS11940	COG0748	coenzyme F420 binding
MY523_RS11950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MY523_RS11995	COG0183	Belongs to the thiolase family
MY523_RS12005	COG1785	Belongs to the alkaline phosphatase family
MY523_RS12010	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MY523_RS12015	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MY523_RS12025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MY523_RS12030	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MY523_RS12035	COG4942	peptidase
MY523_RS12045	COG2861	carbohydrate metabolic process
MY523_RS12055	COG0107	imidazoleglycerol-phosphate synthase activity
MY523_RS12060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MY523_RS12065	COG0131	Imidazoleglycerol-phosphate dehydratase
MY523_RS12085	COG5001	Diguanylate cyclase
MY523_RS12085	COG4251	negative regulation of phosphorylation
MY523_RS12085	COG3706	GGDEF domain
MY523_RS12085	COG2203	Gaf domain
MY523_RS12090	COG0745	RESPONSE REGULATOR receiver
MY523_RS12095	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MY523_RS12135	COG5001	Diguanylate cyclase
MY523_RS12135	COG4251	negative regulation of phosphorylation
MY523_RS12135	COG3706	GGDEF domain
MY523_RS12135	COG2203	Gaf domain
MY523_RS12160	COG4160	amino acid transport
MY523_RS12165	COG2988	succinylglutamate desuccinylase activity
MY523_RS12170	COG3724	N-succinylarginine dihydrolase activity
MY523_RS12175	COG1012	belongs to the aldehyde dehydrogenase family
MY523_RS12190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MY523_RS12195	COG0840	transmembrane signaling receptor activity
MY523_RS12205	COG0579	oxidoreductase
MY523_RS12245	COG4106	trans-aconitate 2-methyltransferase activity
MY523_RS12250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MY523_RS12255	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MY523_RS12260	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MY523_RS12270	COG0330	HflC and HflK could
MY523_RS12275	COG0330	HflC and HflK could
MY523_RS12280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MY523_RS12285	COG1923	regulation of RNA biosynthetic process
MY523_RS12290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MY523_RS12295	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MY523_RS12300	COG0860	N-Acetylmuramoyl-L-alanine amidase
MY523_RS12305	COG0802	atpase or kinase
MY523_RS12310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MY523_RS12310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MY523_RS12320	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MY523_RS12325	COG1162	GTPase activity
MY523_RS12350	COG0688	phosphatidylethanolamine metabolic process
MY523_RS12355	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MY523_RS12360	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MY523_RS12365	COG1509	lysine 2,3-aminomutase activity
MY523_RS12390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MY523_RS12395	COG0850	regulation of cytokinetic process
MY523_RS12400	COG2894	cell division
MY523_RS12425	COG1309	transcriptional regulator
MY523_RS12430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MY523_RS12435	COG0583	DNA-binding transcription factor activity
MY523_RS12445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MY523_RS12465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MY523_RS12470	COG2890	protein-(glutamine-N5) methyltransferase activity
MY523_RS12475	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MY523_RS12480	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MY523_RS12490	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MY523_RS12495	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MY523_RS12505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MY523_RS12510	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MY523_RS12515	COG0193	aminoacyl-tRNA hydrolase activity
MY523_RS12520	COG0012	GTP binding
MY523_RS12525	COG4974	Belongs to the 'phage' integrase family
MY523_RS12680	COG3344	reverse transcriptase
MY523_RS12760	COG5001	Diguanylate cyclase
MY523_RS12760	COG2203	Gaf domain
MY523_RS12760	COG3706	GGDEF domain
MY523_RS12760	COG4251	negative regulation of phosphorylation
MY523_RS12795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MY523_RS12800	COG3047	cAMP biosynthetic process
MY523_RS12810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MY523_RS12815	COG0305	Participates in initiation and elongation during chromosome replication
MY523_RS12820	COG0359	binds to the 23S rRNA
MY523_RS12830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MY523_RS12835	COG0360	Binds together with S18 to 16S ribosomal RNA
MY523_RS12840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MY523_RS12845	COG0557	exoribonuclease II activity
MY523_RS12920	COG1199	ATP-dependent helicase activity
MY523_RS12920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MY523_RS12950	COG1136	(ABC) transporter
MY523_RS12950	COG0577	efflux transmembrane transporter activity
MY523_RS12960	COG0577	efflux transmembrane transporter activity
MY523_RS12960	COG1136	(ABC) transporter
MY523_RS12990	COG4372	Transposase
MY523_RS12995	COG1607	acyl-coa hydrolase
MY523_RS13015	COG0435	Glutathione S-transferase
MY523_RS13020	COG0583	DNA-binding transcription factor activity
MY523_RS13040	COG0247	lactate metabolic process
MY523_RS13045	COG1139	Iron-sulfur cluster binding protein
MY523_RS13115	COG1073	alpha beta
MY523_RS13120	COG1185	polyribonucleotide nucleotidyltransferase activity
MY523_RS13125	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MY523_RS13130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MY523_RS13135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MY523_RS13140	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MY523_RS13140	COG3064	Membrane
MY523_RS13145	COG0195	Participates in both transcription termination and antitermination
MY523_RS13165	COG0149	triose-phosphate isomerase activity
MY523_RS13170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MY523_RS13175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MY523_RS13180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MY523_RS13185	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MY523_RS13195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MY523_RS13205	COG0505	Belongs to the CarA family
MY523_RS13210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MY523_RS13215	COG0484	heat shock protein binding
MY523_RS13220	COG0443	Heat shock 70 kDa protein
MY523_RS13225	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MY523_RS13230	COG0497	DNA recombination
MY523_RS13245	COG2914	Belongs to the UPF0125 (RnfH) family
MY523_RS13255	COG0733	neurotransmitter:sodium symporter activity
MY523_RS13260	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MY523_RS13295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MY523_RS13300	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MY523_RS13365	COG2204	response regulator
MY523_RS13465	COG2207	Transcriptional regulator
MY523_RS13480	COG0071	Belongs to the small heat shock protein (HSP20) family
MY523_RS13505	COG1942	4-Oxalocrotonate Tautomerase
MY523_RS13515	COG1090	epimerase
MY523_RS13520	COG0789	Transcriptional regulator
MY523_RS13540	COG2204	response regulator
MY523_RS13550	COG2205	protein histidine kinase activity
MY523_RS13560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MY523_RS13575	COG0514	ATP-dependent DNA helicase (RecQ)
MY523_RS13610	COG0628	permease
MY523_RS13645	COG3706	GGDEF domain
MY523_RS13650	COG3268	Saccharopine dehydrogenase
MY523_RS13655	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MY523_RS13670	COG1408	metallophosphoesterase
MY523_RS13705	COG1024	Enoyl-CoA hydratase
MY523_RS13715	COG0318	PFAM AMP-dependent synthetase and ligase
MY523_RS13725	COG2226	methyltransferase
MY523_RS13735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MY523_RS13740	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MY523_RS13745	COG0140	phosphoribosyl-ATP diphosphatase activity
MY523_RS13750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MY523_RS13755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MY523_RS13765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MY523_RS13785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MY523_RS13790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MY523_RS13795	COG0006	proline dipeptidase activity
MY523_RS13820	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MY523_RS13830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MY523_RS13880	COG2814	Major facilitator Superfamily
MY523_RS13885	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MY523_RS13890	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MY523_RS13930	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MY523_RS13945	COG0784	Response regulator, receiver
MY523_RS13945	COG2205	protein histidine kinase activity
MY523_RS13950	COG1960	acyl-CoA dehydrogenase activity
MY523_RS13965	COG3901	Regulator of nitric oxide reductase transcription
MY523_RS13965	COG0348	domain, Protein
MY523_RS13985	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MY523_RS14010	COG5001	Diguanylate cyclase
MY523_RS14010	COG3300	MHYT domain
MY523_RS14020	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MY523_RS14025	COG0511	ligase activity, forming carbon-carbon bonds
MY523_RS14035	COG2264	protein methyltransferase activity
MY523_RS14055	COG0138	bifunctional purine biosynthesis protein purh
MY523_RS14060	COG0151	Belongs to the GarS family
MY523_RS14085	COG0786	glutamate:sodium symporter activity
MY523_RS14095	COG0678	peroxiredoxin activity
MY523_RS14095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MY523_RS14105	COG0840	transmembrane signaling receptor activity
MY523_RS14115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MY523_RS14130	COG0077	Prephenate dehydratase
MY523_RS14130	COG1605	Chorismate mutase
MY523_RS14135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MY523_RS14140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MY523_RS14145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MY523_RS14170	COG1309	transcriptional regulator
MY523_RS14175	COG2022	thiamine diphosphate biosynthetic process
MY523_RS14185	COG2363	Small membrane protein
MY523_RS14190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MY523_RS14195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MY523_RS14200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MY523_RS14205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MY523_RS14210	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MY523_RS14215	COG3178	'Phosphotransferase
MY523_RS14230	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MY523_RS14235	COG0546	phosphoglycolate phosphatase activity
MY523_RS14240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MY523_RS14250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MY523_RS14255	COG0134	indole-3-glycerol-phosphate synthase activity
MY523_RS14265	COG0625	glutathione transferase activity
MY523_RS14270	COG0625	glutathione transferase activity
MY523_RS14285	COG0745	RESPONSE REGULATOR receiver
MY523_RS14295	COG0745	RESPONSE REGULATOR receiver
MY523_RS14300	COG5002	protein histidine kinase activity
MY523_RS14305	COG0741	lytic transglycosylase activity
MY523_RS14310	COG0435	Glutathione S-transferase
MY523_RS14320	COG3118	belongs to the thioredoxin family
MY523_RS14330	COG3001	Fructosamine kinase
MY523_RS14375	COG0659	secondary active sulfate transmembrane transporter activity
MY523_RS14380	COG0318	PFAM AMP-dependent synthetase and ligase
MY523_RS14400	COG4269	membrane
MY523_RS14420	COG0318	PFAM AMP-dependent synthetase and ligase
MY523_RS14435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MY523_RS14450	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MY523_RS14455	COG0210	DNA helicase
MY523_RS14485	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MY523_RS14495	COG1794	racemase activity, acting on amino acids and derivatives
MY523_RS14500	COG2315	Protein conserved in bacteria
MY523_RS14505	COG0517	IMP dehydrogenase activity
MY523_RS14505	COG0516	GMP reductase activity
MY523_RS14515	COG3842	ATPase activity
MY523_RS14520	COG1176	ABC-type spermidine putrescine transport system, permease component I
MY523_RS14525	COG1177	transmembrane transport
MY523_RS14530	COG0519	Catalyzes the synthesis of GMP from XMP
MY523_RS14540	COG1012	belongs to the aldehyde dehydrogenase family
MY523_RS14555	COG0604	alcohol dehydrogenase
MY523_RS14565	COG0686	Belongs to the AlaDH PNT family
MY523_RS14585	COG1272	protein, Hemolysin III
MY523_RS14590	COG1858	cytochrome C peroxidase
MY523_RS14595	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MY523_RS14625	COG1454	alcohol dehydrogenase
MY523_RS14660	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MY523_RS14685	COG4191	Histidine kinase
MY523_RS14685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MY523_RS14690	COG0784	Response regulator, receiver
MY523_RS14690	COG3437	response regulator, receiver
MY523_RS14695	COG0301	tRNA thio-modification
MY523_RS14695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MY523_RS14700	COG1611	Belongs to the LOG family
MY523_RS14715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MY523_RS14730	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MY523_RS14745	COG1960	acyl-CoA dehydrogenase activity
MY523_RS14750	COG1024	Enoyl-CoA hydratase
MY523_RS14755	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MY523_RS14775	COG0210	DNA helicase
MY523_RS14790	COG2072	flavoprotein involved in K transport
MY523_RS14795	COG1752	Esterase of the alpha-beta hydrolase superfamily
MY523_RS14830	COG3344	reverse transcriptase
MY523_RS14895	COG2885	chlorophyll binding
MY523_RS14915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MY523_RS14930	COG0745	RESPONSE REGULATOR receiver
MY523_RS14935	COG2205	protein histidine kinase activity
MY523_RS14990	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MY523_RS15000	COG2177	Part of the ABC transporter FtsEX involved in
MY523_RS15005	COG2884	Cell division ATP-binding protein ftsE
MY523_RS15010	COG0552	protein localization to endoplasmic reticulum
MY523_RS15015	COG0742	ribosomal rna small subunit methyltransferase
MY523_RS15025	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MY523_RS15040	COG1011	Hydrolase
MY523_RS15045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MY523_RS15050	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MY523_RS15055	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MY523_RS15085	COG1555	photosystem II stabilization
MY523_RS15090	COG2095	MarC family integral membrane protein
MY523_RS15100	COG0540	Belongs to the ATCase OTCase family
MY523_RS15110	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MY523_RS15115	COG1678	Uncharacterized ACR, COG1678
MY523_RS15125	COG0189	ligase activity
MY523_RS15145	COG0840	transmembrane signaling receptor activity
MY523_RS15155	COG0643	Histidine kinase
MY523_RS15155	COG2198	Histidine kinase
MY523_RS15160	COG2201	protein-glutamate methylesterase activity
MY523_RS15180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MY523_RS15190	COG0204	Acyl-transferase
MY523_RS15210	COG1309	transcriptional regulator
MY523_RS15215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MY523_RS15225	COG0840	transmembrane signaling receptor activity
MY523_RS15240	COG2918	glutathione biosynthetic process
MY523_RS15250	COG2183	response to ionizing radiation
MY523_RS15270	COG1943	Transposase
MY523_RS15275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MY523_RS15280	COG1695	Transcriptional regulator
MY523_RS15405	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MY523_RS15430	COG3437	response regulator, receiver
MY523_RS15430	COG2205	protein histidine kinase activity
MY523_RS15430	COG3850	Histidine kinase
MY523_RS15430	COG4999	Histidine kinase
MY523_RS15440	COG2823	Periplasmic or secreted lipoprotein
MY523_RS15455	COG1597	lipid kinase activity
MY523_RS15455	COG1803	Methylglyoxal synthase
MY523_RS15470	COG1511	domain protein
MY523_RS15470	COG3264	Mechanosensitive ion channel
MY523_RS15490	COG4221	oxidoreductase activity
MY523_RS15500	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
MY523_RS15505	COG0657	acetylesterase activity
MY523_RS15515	COG1760	l-serine dehydratase
MY523_RS15545	COG3274	enterobacterial common antigen metabolic process
MY523_RS15550	COG0069	glutamate synthase activity
MY523_RS15565	COG1127	ABC transporter
MY523_RS15570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MY523_RS15580	COG4335	DNA alkylation repair
MY523_RS15640	COG2205	protein histidine kinase activity
MY523_RS15645	COG0745	RESPONSE REGULATOR receiver
MY523_RS15650	COG2911	Protein conserved in bacteria
MY523_RS15670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MY523_RS15680	COG0508	dehydrogenase complex catalyzes the overall conversion of
MY523_RS15740	COG3344	reverse transcriptase
MY523_RS15800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MY523_RS15815	COG1752	Esterase of the alpha-beta hydrolase superfamily
MY523_RS15825	COG5001	Diguanylate cyclase
MY523_RS15825	COG3300	MHYT domain
MY523_RS15830	COG4206	TonB-dependent receptor
MY523_RS15845	COG1120	ATPase activity
MY523_RS15860	COG0784	Response regulator, receiver
MY523_RS15860	COG2198	Histidine kinase
MY523_RS15860	COG2205	protein histidine kinase activity
MY523_RS15870	COG1011	Hydrolase
MY523_RS15880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MY523_RS15885	COG0019	diaminopimelate decarboxylase activity
MY523_RS15900	COG5001	Diguanylate cyclase
MY523_RS15900	COG5002	protein histidine kinase activity
MY523_RS15900	COG3447	MASE1 domain protein
MY523_RS15905	COG0165	Argininosuccinate lyase
MY523_RS15910	COG3275	phosphorelay sensor kinase activity
MY523_RS15920	COG0181	hydroxymethylbilane synthase activity
MY523_RS15930	COG2959	enzyme of heme biosynthesis
MY523_RS15935	COG3071	HemY protein
MY523_RS15945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MY523_RS15960	COG0521	Mo-molybdopterin cofactor biosynthetic process
MY523_RS15965	COG0303	'Molybdopterin
MY523_RS15970	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MY523_RS15975	COG0314	molybdopterin synthase activity
MY523_RS15980	COG0746	molybdenum cofactor guanylyltransferase activity
MY523_RS15995	COG0625	glutathione transferase activity
MY523_RS16005	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MY523_RS16015	COG2197	response regulator
MY523_RS16020	COG3850	Histidine kinase
MY523_RS16035	COG0243	molybdopterin cofactor binding
MY523_RS16040	COG0437	4 iron, 4 sulfur cluster binding
MY523_RS16045	COG0348	domain, Protein
MY523_RS16050	COG3043	anaerobic respiration
MY523_RS16055	COG3005	denitrification pathway
MY523_RS16080	COG0488	(ABC) transporter
MY523_RS16115	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MY523_RS16130	COG0302	gtp cyclohydrolase
MY523_RS16135	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MY523_RS16140	COG1832	CoA-binding protein
MY523_RS16160	COG2827	Endonuclease containing a URI domain
MY523_RS16185	COG1272	protein, Hemolysin III
MY523_RS16215	COG0789	Transcriptional regulator
MY523_RS16220	COG2217	Heavy metal translocating P-type atpase
MY523_RS16265	COG4191	Histidine kinase
MY523_RS16275	COG4251	negative regulation of phosphorylation
MY523_RS16275	COG3706	GGDEF domain
MY523_RS16275	COG2203	Gaf domain
MY523_RS16275	COG5001	Diguanylate cyclase
MY523_RS16290	COG0133	tryptophan synthase activity
MY523_RS16295	COG3549	Plasmid maintenance system killer
MY523_RS16300	COG3093	addiction module antidote protein HigA
MY523_RS16325	COG0534	Mate efflux family protein
MY523_RS16335	COG0500	methyltransferase
MY523_RS16360	COG1902	pentaerythritol trinitrate reductase activity
MY523_RS16360	COG0446	pyridine nucleotide-disulphide oxidoreductase
MY523_RS16400	COG2304	oxidoreductase activity
MY523_RS16420	COG4191	Histidine kinase
MY523_RS16425	COG0604	alcohol dehydrogenase
MY523_RS16425	COG1028	Short-chain dehydrogenase reductase Sdr
MY523_RS16425	COG3321	synthase
MY523_RS16435	COG2095	MarC family integral membrane protein
MY523_RS16465	COG1309	transcriptional regulator
MY523_RS16480	COG0840	transmembrane signaling receptor activity
MY523_RS16485	COG0443	Heat shock 70 kDa protein
MY523_RS16525	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MY523_RS16550	COG2169	Transcriptional regulator
MY523_RS16550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MY523_RS16590	COG1017	nitric oxide dioxygenase activity
MY523_RS16590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MY523_RS16595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MY523_RS16595	COG5322	oxidoreductase activity
MY523_RS16600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MY523_RS16630	COG0471	metal ion transport
MY523_RS16630	COG0490	domain, Protein
MY523_RS16655	COG2814	Major facilitator Superfamily
MY523_RS16675	COG0583	DNA-binding transcription factor activity
MY523_RS16715	COG0348	domain, Protein
MY523_RS16730	COG1280	lysine exporter protein (LysE YggA)
MY523_RS16735	COG0443	Heat shock 70 kDa protein
MY523_RS16740	COG0443	Heat shock 70 kDa protein
MY523_RS16755	COG1162	GTPase activity
MY523_RS16780	COG1252	NADH dehydrogenase
MY523_RS16790	COG0583	DNA-binding transcription factor activity
MY523_RS16840	COG0697	spore germination
MY523_RS16845	COG1279	arginine transmembrane transporter activity
MY523_RS16855	COG0545	Peptidyl-prolyl cis-trans isomerase
MY523_RS16875	COG2703	oxygen carrier activity
MY523_RS16915	COG1028	Short-chain dehydrogenase reductase Sdr
MY523_RS16920	COG2111	Na H antiporter
MY523_RS16920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MY523_RS16925	COG1006	Multisubunit Na H antiporter MnhC subunit
MY523_RS16930	COG0651	ATP synthesis coupled electron transport
MY523_RS16935	COG1863	multisubunit Na H antiporter MnhE subunit
MY523_RS16940	COG2212	antiporter activity
MY523_RS16975	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MY523_RS16995	COG1269	ATP hydrolysis coupled proton transport
MY523_RS17010	COG1230	cation diffusion facilitator family transporter
MY523_RS17040	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MY523_RS17115	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
MY523_RS17120	COG1178	ABC-type Fe3 transport system permease component
MY523_RS17145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MY523_RS17155	COG0745	RESPONSE REGULATOR receiver
MY523_RS17180	COG4636	protein conserved in cyanobacteria
MY523_RS17205	COG1132	(ABC) transporter
MY523_RS17220	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MY523_RS17235	COG1752	Esterase of the alpha-beta hydrolase superfamily
MY523_RS17240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MY523_RS17275	COG2205	protein histidine kinase activity
MY523_RS17275	COG0784	Response regulator, receiver
MY523_RS17275	COG5002	protein histidine kinase activity
MY523_RS17355	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MY523_RS17360	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
MY523_RS17365	COG3454	Phosphonate metabolism
MY523_RS17370	COG4778	phosphonate C-P lyase system protein PhnL
MY523_RS17375	COG4107	phosphonate C-P lyase system protein PhnK
MY523_RS17385	COG3626	phosphonate metabolism
MY523_RS17390	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
MY523_RS17395	COG3624	Phosphonate C-P lyase system protein PhnG
MY523_RS17400	COG2188	Transcriptional regulator
MY523_RS17405	COG3639	organic phosphonate transmembrane transporter activity
MY523_RS17410	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
MY523_RS17420	COG2095	MarC family integral membrane protein
MY523_RS17435	COG0848	biopolymer transport protein
MY523_RS17440	COG0811	peptide transport
MY523_RS17445	COG0811	peptide transport
MY523_RS17475	COG2189	Belongs to the N(4) N(6)-methyltransferase family
MY523_RS17485	COG3609	addiction module antidote protein, CC2985 family
MY523_RS17550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MY523_RS17555	COG1773	rubredoxin
MY523_RS17560	COG1773	rubredoxin
MY523_RS17605	COG3384	dioxygenase
MY523_RS17700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MY523_RS17715	COG0705	Rhomboid family
MY523_RS17740	COG1842	Phage shock protein A
MY523_RS17785	COG1797	cobyrinic acid a,c-diamide synthase activity
MY523_RS17800	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MY523_RS17880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MY523_RS17885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MY523_RS17890	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MY523_RS17895	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MY523_RS17900	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MY523_RS17905	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MY523_RS17910	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MY523_RS17915	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MY523_RS17925	COG0356	it plays a direct role in the translocation of protons across the membrane
MY523_RS17935	COG1475	DNA binding
MY523_RS17940	COG1192	Involved in chromosome partitioning
MY523_RS17945	COG0357	Ribosomal RNA small subunit methyltransferase G
MY523_RS17950	COG0445	tRNA wobble uridine modification
MY523_RS17960	COG0426	domain, Protein
MY523_RS17960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MY523_RS17970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MY523_RS17975	COG0706	membrane insertase activity
MY523_RS17980	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MY523_RS17985	COG0594	ribonuclease P activity
MY523_RS17995	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MY523_RS18000	COG0592	DNA-directed DNA polymerase activity
MY523_RS18015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MY523_RS18045	COG1560	Kdo2-lipid A biosynthetic process
MY523_RS18050	COG0751	glycine-tRNA ligase activity
MY523_RS18055	COG0752	glycyl-tRNA synthetase alpha subunit
MY523_RS18090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MY523_RS18095	COG0569	domain protein
MY523_RS18105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MY523_RS18110	COG0242	peptide deformylase activity
MY523_RS18120	COG0758	DNA mediated transformation
MY523_RS18125	COG0009	L-threonylcarbamoyladenylate synthase
MY523_RS18135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MY523_RS18140	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MY523_RS18155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MY523_RS18160	COG0339	signal peptide processing
MY523_RS18180	COG0534	Mate efflux family protein
MY523_RS18220	COG1612	heme a metabolic process
MY523_RS18225	COG0109	protoheme IX farnesyltransferase activity
MY523_RS18230	COG3920	Histidine kinase
MY523_RS18245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MY523_RS18270	COG2015	COG2015, Alkyl sulfatase and related hydrolases
MY523_RS18280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MY523_RS18300	COG0784	Response regulator, receiver
MY523_RS18300	COG2205	protein histidine kinase activity
MY523_RS18310	COG0745	RESPONSE REGULATOR receiver
MY523_RS18405	COG0784	Response regulator, receiver
MY523_RS18405	COG2205	protein histidine kinase activity
MY523_RS18410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MY523_RS18415	COG0602	queuosine metabolic process
MY523_RS18420	COG0243	molybdopterin cofactor binding
MY523_RS18435	COG0583	DNA-binding transcription factor activity
MY523_RS18475	COG2195	Cleaves the N-terminal amino acid of tripeptides
MY523_RS18480	COG3360	Dodecin
MY523_RS18490	COG3550	peptidyl-serine autophosphorylation
MY523_RS18520	COG0318	PFAM AMP-dependent synthetase and ligase
MY523_RS18545	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MY523_RS18550	COG0513	Belongs to the DEAD box helicase family
MY523_RS18560	COG0017	Asparaginyl-tRNA synthetase
MY523_RS18565	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MY523_RS18565	COG0392	lysyltransferase activity
MY523_RS18590	COG0545	Peptidyl-prolyl cis-trans isomerase
MY523_RS18620	COG0583	DNA-binding transcription factor activity
MY523_RS18625	COG4608	Belongs to the ABC transporter superfamily
MY523_RS18630	COG0444	Belongs to the ABC transporter superfamily
MY523_RS18635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MY523_RS18640	COG0601	transmembrane transport
MY523_RS18645	COG0747	negative chemotaxis
MY523_RS18660	COG0579	oxidoreductase
MY523_RS18685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MY523_RS18725	COG2354	Protein conserved in bacteria
MY523_RS18730	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MY523_RS18740	COG0583	DNA-binding transcription factor activity
MY523_RS18765	COG2832	Protein of unknown function (DUF454)
MY523_RS18775	COG2026	Addiction module toxin, RelE StbE family
MY523_RS18780	COG0840	transmembrane signaling receptor activity
MY523_RS18785	COG1047	Peptidyl-prolyl cis-trans
MY523_RS18805	COG1942	4-Oxalocrotonate Tautomerase
MY523_RS18810	COG3177	Filamentation induced by cAMP protein fic
MY523_RS18815	COG3530	Putative quorum-sensing-regulated virulence factor
MY523_RS18835	COG0545	Peptidyl-prolyl cis-trans isomerase
MY523_RS18840	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MY523_RS18855	COG2197	response regulator
MY523_RS18895	COG5002	protein histidine kinase activity
MY523_RS18900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MY523_RS18920	COG1739	Uncharacterized protein family UPF0029
MY523_RS18945	COG3220	belongs to the UPF0276 family
MY523_RS18960	COG1942	4-Oxalocrotonate Tautomerase
MY523_RS18965	COG0477	Major facilitator Superfamily
MY523_RS18970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MY523_RS18970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MY523_RS18985	COG0745	RESPONSE REGULATOR receiver
MY523_RS18990	COG5002	protein histidine kinase activity
MY523_RS19005	COG3655	Transcriptional regulator
MY523_RS19010	COG0753	catalase activity
MY523_RS19025	COG4251	negative regulation of phosphorylation
MY523_RS19030	COG0784	Response regulator, receiver
MY523_RS19035	COG0730	response to heat
MY523_RS19060	COG4681	YaeQ
MY523_RS19070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MY523_RS19085	COG2205	protein histidine kinase activity
MY523_RS19085	COG3437	response regulator, receiver
MY523_RS19085	COG3850	Histidine kinase
MY523_RS19085	COG4999	Histidine kinase
MY523_RS19095	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MY523_RS19100	COG4221	oxidoreductase activity
MY523_RS19120	COG0346	lactoylglutathione lyase activity
MY523_RS19180	COG3344	reverse transcriptase
MY523_RS19190	COG0517	IMP dehydrogenase activity
MY523_RS19195	COG4974	Belongs to the 'phage' integrase family
MY523_RS19200	COG0033	Phosphoglucomutase
MY523_RS19210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MY523_RS19215	COG3122	Protein conserved in bacteria
MY523_RS19280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MY523_RS19285	COG3089	Belongs to the UPF0270 family
MY523_RS19290	COG1250	3-hydroxyacyl-CoA dehydrogenase
MY523_RS19290	COG1024	Enoyl-CoA hydratase
MY523_RS19315	COG2204	response regulator
MY523_RS19325	COG2378	regulation of single-species biofilm formation
MY523_RS19360	COG1671	Belongs to the UPF0178 family
MY523_RS19370	COG1278	Cold shock
MY523_RS19395	COG3123	guanosine phosphorylase activity
MY523_RS19420	COG1278	Cold shock
MY523_RS19430	COG3647	Membrane
MY523_RS19450	COG0596	Alpha beta hydrolase
MY523_RS19465	COG3344	reverse transcriptase
MY523_RS19495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MY523_RS19500	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MY523_RS19505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MY523_RS19510	COG2204	response regulator
MY523_RS19515	COG4191	Histidine kinase
MY523_RS19545	COG4115	mRNA cleavage
MY523_RS19550	COG2161	toxin-antitoxin pair type II binding
MY523_RS19565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MY523_RS19575	COG1126	abc transporter atp-binding protein
MY523_RS19580	COG0765	amino acid transport
MY523_RS19585	COG4597	amino acid ABC transporter
MY523_RS19590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MY523_RS19600	COG3148	PFAM DTW domain containing protein
MY523_RS19625	COG2337	Toxic component of a toxin-antitoxin (TA) module
MY523_RS19630	COG2336	PFAM SpoVT AbrB
MY523_RS19645	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MY523_RS19655	COG1960	acyl-CoA dehydrogenase activity
MY523_RS19670	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MY523_RS19685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MY523_RS19695	COG1166	arginine decarboxylase activity
MY523_RS19700	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MY523_RS19720	COG0004	ammonium transporteR
MY523_RS19725	COG0347	Belongs to the P(II) protein family
MY523_RS19735	COG0606	chelatase, subunit chli
MY523_RS19745	COG1116	anion transmembrane transporter activity
MY523_RS19755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MY523_RS19755	COG1116	anion transmembrane transporter activity
MY523_RS19765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MY523_RS19770	COG0590	tRNA wobble adenosine to inosine editing
MY523_RS19775	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MY523_RS19785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MY523_RS19790	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MY523_RS19800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MY523_RS19800	COG2813	Specifically methylates the guanine in position
MY523_RS19805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MY523_RS19815	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MY523_RS19855	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MY523_RS19860	COG0826	peptidase U32
MY523_RS19880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MY523_RS19890	COG1025	Belongs to the peptidase M16 family
MY523_RS19895	COG2771	luxR family
MY523_RS19915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MY523_RS19925	COG1538	Outer membrane efflux protein
MY523_RS19935	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MY523_RS19940	COG1561	YicC-like family, N-terminal region
MY523_RS19965	COG3550	peptidyl-serine autophosphorylation
MY523_RS19970	COG3620	sequence-specific DNA binding
MY523_RS19975	COG1024	Enoyl-CoA hydratase
MY523_RS19980	COG1902	pentaerythritol trinitrate reductase activity
MY523_RS19980	COG0446	pyridine nucleotide-disulphide oxidoreductase
MY523_RS19990	COG1309	transcriptional regulator
MY523_RS19995	COG3177	Filamentation induced by cAMP protein fic
MY523_RS20010	COG3436	PFAM IS66 Orf2 family protein
MY523_RS20025	COG0494	nUDIX hydrolase
MY523_RS20040	COG5001	Diguanylate cyclase
MY523_RS20040	COG4251	negative regulation of phosphorylation
MY523_RS20040	COG3706	GGDEF domain
MY523_RS20040	COG2203	Gaf domain
MY523_RS20050	COG1758	RNA polymerase activity
MY523_RS20055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MY523_RS20070	COG0583	DNA-binding transcription factor activity
MY523_RS20075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MY523_RS20195	COG1610	YqeY-like protein
MY523_RS20200	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MY523_RS20205	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MY523_RS20210	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MY523_RS20215	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MY523_RS20220	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MY523_RS20220	COG0302	gtp cyclohydrolase
MY523_RS20225	COG0166	Belongs to the GPI family
MY523_RS20230	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MY523_RS20235	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MY523_RS20245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MY523_RS20255	COG2204	response regulator
MY523_RS20260	COG4191	Histidine kinase
MY523_RS20265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MY523_RS20270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MY523_RS20305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MY523_RS20320	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MY523_RS20325	COG0352	thiamine-phosphate diphosphorylase activity
MY523_RS20330	COG0351	phosphomethylpyrimidine kinase
MY523_RS20330	COG0352	thiamine-phosphate diphosphorylase activity
MY523_RS20335	COG1981	membrane
MY523_RS20345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MY523_RS20360	COG0316	Belongs to the HesB IscA family
MY523_RS20370	COG0739	heme binding
MY523_RS20375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MY523_RS20440	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MY523_RS20440	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MY523_RS20485	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MY523_RS20490	COG0081	regulation of translation
MY523_RS20495	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MY523_RS20500	COG0222	ribosome binding
MY523_RS20505	COG0085	RNA polymerase activity
MY523_RS20510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MY523_RS20515	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MY523_RS20520	COG0049	tRNA binding
MY523_RS20525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MY523_RS20530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MY523_RS20535	COG0051	transcription antitermination factor activity, RNA binding
MY523_RS20540	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MY523_RS20545	COG0088	Forms part of the polypeptide exit tunnel
MY523_RS20550	COG0089	rRNA binding
MY523_RS20555	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MY523_RS20560	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MY523_RS20565	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MY523_RS20570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MY523_RS20575	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MY523_RS20580	COG0255	Belongs to the universal ribosomal protein uL29 family
MY523_RS20585	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MY523_RS20590	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MY523_RS20595	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MY523_RS20600	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MY523_RS20605	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MY523_RS20610	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MY523_RS20615	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MY523_RS20620	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MY523_RS20625	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MY523_RS20630	COG1841	ribosomal large subunit assembly
MY523_RS20635	COG0200	Binds to the 23S rRNA
MY523_RS20645	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MY523_RS20650	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MY523_RS20655	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MY523_RS20660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MY523_RS20665	COG0202	RNA polymerase activity
MY523_RS20670	COG0203	ribosomal protein L17
MY523_RS20680	COG2814	Major facilitator Superfamily
MY523_RS20695	COG0527	aspartate kinase activity
MY523_RS20700	COG1917	Cupin 2, conserved barrel domain protein
MY523_RS20710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MY523_RS20720	COG1846	Transcriptional regulator
MY523_RS20750	COG3267	Type II secretory pathway component ExeA
MY523_RS20750	COG3409	Peptidoglycan-binding domain 1 protein
MY523_RS20760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MY523_RS20765	COG1459	type II secretion system
MY523_RS20810	COG2204	response regulator
MY523_RS20815	COG3852	Histidine kinase
MY523_RS20825	COG0174	glutamine synthetase
MY523_RS20830	COG1217	gtp-binding protein TYPA
MY523_RS20840	COG1490	D-aminoacyl-tRNA deacylase activity
MY523_RS20850	COG4116	CYTH
MY523_RS20885	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MY523_RS20905	COG0110	maltose O-acetyltransferase activity
MY523_RS20915	COG1696	Membrane protein involved in D-alanine export
MY523_RS20930	COG1216	Glycosyl transferase, family 2
MY523_RS20930	COG1442	glycosyl transferase family 8
MY523_RS20945	COG0726	polysaccharide deacetylase
MY523_RS20960	COG1519	Transferase
MY523_RS20965	COG1538	Outer membrane efflux protein
MY523_RS20970	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MY523_RS20975	COG0494	nUDIX hydrolase
MY523_RS20985	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MY523_RS20990	COG3150	esterase
MY523_RS20995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MY523_RS21000	COG0509	glycine decarboxylation via glycine cleavage system
MY523_RS21005	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MY523_RS21010	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MY523_RS21035	COG0494	nUDIX hydrolase
MY523_RS21040	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
MY523_RS21055	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MY523_RS21060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MY523_RS21070	COG0018	arginyl-trna synthetase
MY523_RS21075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MY523_RS21080	COG0254	rRNA binding
MY523_RS21090	COG0281	malic enzyme
MY523_RS21095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MY523_RS21100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MY523_RS21105	COG2003	Belongs to the UPF0758 family
MY523_RS21110	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MY523_RS21115	COG0756	dUTP diphosphatase activity
MY523_RS21125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MY523_RS21130	COG3706	GGDEF domain
MY523_RS21145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MY523_RS21145	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MY523_RS21155	COG5001	Diguanylate cyclase
MY523_RS21155	COG5002	protein histidine kinase activity
MY523_RS21160	COG3954	Phosphoribulokinase
MY523_RS21170	COG1765	OsmC-like protein
MY523_RS21185	COG0288	reversible hydration of carbon dioxide
MY523_RS21200	COG1607	acyl-coa hydrolase
MY523_RS21225	COG0581	inorganic phosphate transmembrane transporter activity
MY523_RS21230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MY523_RS21250	COG0537	adenosine 5'-monophosphoramidase activity
MY523_RS21255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MY523_RS21265	COG0668	transmembrane transport
MY523_RS21270	COG0709	Synthesizes selenophosphate from selenide and ATP
MY523_RS21275	COG3639	organic phosphonate transmembrane transporter activity
MY523_RS21280	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MY523_RS21285	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
MY523_RS21290	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
MY523_RS21305	COG0564	pseudouridine synthase activity
MY523_RS21340	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MY523_RS21345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MY523_RS21350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MY523_RS21355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MY523_RS21375	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MY523_RS21380	COG3161	chorismate lyase activity
MY523_RS21410	COG1946	Acyl-CoA thioesterase
MY523_RS21435	COG0306	phosphate transporter
MY523_RS21440	COG2203	Gaf domain
MY523_RS21440	COG3706	GGDEF domain
MY523_RS21440	COG4251	negative regulation of phosphorylation
MY523_RS21440	COG5001	Diguanylate cyclase
MY523_RS21455	COG0076	glutamate decarboxylase activity
MY523_RS21490	COG1960	acyl-CoA dehydrogenase activity
MY523_RS21500	COG1309	transcriptional regulator
MY523_RS21510	COG1444	tRNA N-acetyltransferase activity
MY523_RS21555	COG0628	permease
MY523_RS21575	COG0405	Gamma-glutamyltransferase
MY523_RS21580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MY523_RS21585	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MY523_RS21600	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MY523_RS21660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MY523_RS21665	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MY523_RS21675	COG0067	glutamate synthase
MY523_RS21675	COG0069	glutamate synthase activity
MY523_RS21675	COG0070	glutamate synthase
MY523_RS21680	COG0493	'glutamate synthase
MY523_RS21685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MY523_RS21700	COG3344	reverse transcriptase
MY523_RS21720	COG0488	(ABC) transporter
MY523_RS21725	COG1742	UPF0060 membrane protein
MY523_RS21735	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MY523_RS21745	COG0640	Transcriptional regulator
MY523_RS21750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MY523_RS21755	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MY523_RS21760	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MY523_RS21760	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MY523_RS21775	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MY523_RS21780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons