locus-tag	class	description
AMET_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AMET_RS00010	COG0592	DNA-directed DNA polymerase activity
AMET_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMET_RS00030	COG0187	DNA topoisomerase II activity
AMET_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AMET_RS00040	COG1366	Belongs to the anti-sigma-factor antagonist family
AMET_RS00085	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMET_RS00090	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMET_RS00110	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AMET_RS00115	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AMET_RS00120	COG0157	Belongs to the NadC ModD family
AMET_RS00125	COG1827	regulation of RNA biosynthetic process
AMET_RS00135	COG1615	UPF0182 protein
AMET_RS00145	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AMET_RS00160	COG0590	tRNA wobble adenosine to inosine editing
AMET_RS00170	COG0425	Belongs to the sulfur carrier protein TusA family
AMET_RS00180	COG0668	transmembrane transport
AMET_RS00190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMET_RS00195	COG0360	Binds together with S18 to 16S ribosomal RNA
AMET_RS00205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AMET_RS00275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMET_RS00280	COG1288	antiporter activity
AMET_RS00285	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AMET_RS00295	COG0840	transmembrane signaling receptor activity
AMET_RS00310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AMET_RS00315	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AMET_RS00325	COG1522	sequence-specific DNA binding
AMET_RS00330	COG1522	sequence-specific DNA binding
AMET_RS00335	COG0535	radical SAM domain protein
AMET_RS00340	COG0535	radical SAM domain protein
AMET_RS00345	COG2855	membrane
AMET_RS00360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMET_RS00365	COG2873	o-acetylhomoserine
AMET_RS00370	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AMET_RS00375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMET_RS00375	COG1648	precorrin-2 dehydrogenase activity
AMET_RS00380	COG0181	hydroxymethylbilane synthase activity
AMET_RS00390	COG0113	porphobilinogen synthase activity
AMET_RS00395	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AMET_RS00405	COG1797	cobyrinic acid a,c-diamide synthase activity
AMET_RS00430	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AMET_RS00485	COG1982	Orn Lys Arg decarboxylase major
AMET_RS00490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AMET_RS00495	COG3870	Protein conserved in bacteria
AMET_RS00505	COG1774	PSP1 C-terminal conserved region
AMET_RS00510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMET_RS00515	COG1191	sigma factor activity
AMET_RS00520	COG2755	lipolytic protein G-D-S-L family
AMET_RS00530	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AMET_RS00535	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AMET_RS00540	COG2002	toxin-antitoxin pair type II binding
AMET_RS00545	COG0617	tRNA 3'-terminal CCA addition
AMET_RS00550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AMET_RS00555	COG2715	membrane protein required for spore maturation
AMET_RS00560	COG0700	Nucleoside recognition
AMET_RS00565	COG3191	aminopeptidase activity
AMET_RS00570	COG4512	PFAM Accessory gene regulator B
AMET_RS00585	COG0577	efflux transmembrane transporter activity
AMET_RS00585	COG1136	(ABC) transporter
AMET_RS00590	COG3290	protein histidine kinase activity
AMET_RS00595	COG3279	Response regulator of the LytR AlgR family
AMET_RS00615	COG1595	DNA-templated transcription, initiation
AMET_RS00625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMET_RS00625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMET_RS00630	COG0084	hydrolase, TatD family'
AMET_RS00655	COG4372	Transposase
AMET_RS00715	COG2217	Heavy metal translocating P-type atpase
AMET_RS00725	COG1725	Transcriptional regulator
AMET_RS00730	COG1131	(ABC) transporter
AMET_RS00740	COG2340	Cysteine-rich secretory protein family
AMET_RS00745	COG3583	domain protein
AMET_RS00745	COG3584	3D domain protein
AMET_RS00755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMET_RS00765	COG0530	calcium, potassium:sodium antiporter activity
AMET_RS00795	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AMET_RS00800	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AMET_RS00805	COG2195	Cleaves the N-terminal amino acid of tripeptides
AMET_RS00810	COG1982	Orn Lys Arg decarboxylase major
AMET_RS00815	COG0714	Associated with various cellular activities
AMET_RS00825	COG1305	Transglutaminase-like
AMET_RS00835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMET_RS00840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMET_RS00845	COG2088	sporulation resulting in formation of a cellular spore
AMET_RS00850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AMET_RS00860	COG0193	aminoacyl-tRNA hydrolase activity
AMET_RS00870	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AMET_RS00880	COG2002	toxin-antitoxin pair type II binding
AMET_RS00890	COG3956	TIGRFAM MazG family protein
AMET_RS00895	COG0776	regulation of translation
AMET_RS00900	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AMET_RS00910	COG2385	sporulation resulting in formation of a cellular spore
AMET_RS00930	COG1098	S1 RNA binding domain
AMET_RS00950	COG0793	Belongs to the peptidase S41A family
AMET_RS00955	COG2373	Large extracellular alpha-helical protein
AMET_RS00975	COG1361	Conserved repeat domain
AMET_RS00980	COG0504	CTP synthase activity
AMET_RS01010	COG1309	transcriptional regulator
AMET_RS01025	COG3206	protein involved in exopolysaccharide biosynthesis
AMET_RS01025	COG0489	protein tyrosine kinase activity
AMET_RS01065	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AMET_RS01080	COG0604	alcohol dehydrogenase
AMET_RS01090	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AMET_RS01095	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AMET_RS01110	COG3307	-O-antigen
AMET_RS01130	COG0728	peptidoglycan biosynthetic process
AMET_RS01145	COG1316	TRANSCRIPTIONal
AMET_RS01150	COG5464	transposase or invertase
AMET_RS01160	COG0606	chelatase, subunit chli
AMET_RS01165	COG0758	DNA mediated transformation
AMET_RS01180	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AMET_RS01180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMET_RS01190	COG3395	kinase activity
AMET_RS01195	COG1454	alcohol dehydrogenase
AMET_RS01200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AMET_RS01205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMET_RS01230	COG1131	(ABC) transporter
AMET_RS01290	COG1406	Chemotaxis phosphatase CheX
AMET_RS01300	COG0840	transmembrane signaling receptor activity
AMET_RS01330	COG4303	Ethanolamine ammonia lyase large subunit
AMET_RS01350	COG1012	belongs to the aldehyde dehydrogenase family
AMET_RS01350	COG1454	alcohol dehydrogenase
AMET_RS01365	COG4869	propanediol catabolic process
AMET_RS01370	COG4820	ethanolamine utilization protein (EutJ)
AMET_RS01385	COG4656	Part of a membrane complex involved in electron transport
AMET_RS01395	COG3192	ethanolamine utilization protein
AMET_RS01410	COG4716	Myosin-crossreactive antigen
AMET_RS01435	COG1086	Polysaccharide biosynthesis protein
AMET_RS01455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMET_RS01460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMET_RS01485	COG0745	RESPONSE REGULATOR receiver
AMET_RS01490	COG5002	protein histidine kinase activity
AMET_RS01490	COG3850	Histidine kinase
AMET_RS01520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AMET_RS01530	COG1360	Flagellar Motor Protein
AMET_RS01555	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMET_RS01570	COG0463	Glycosyl transferase, family 2
AMET_RS01575	COG2246	polysaccharide biosynthetic process
AMET_RS01610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMET_RS01615	COG1309	transcriptional regulator
AMET_RS01620	COG0733	neurotransmitter:sodium symporter activity
AMET_RS01630	COG1607	acyl-coa hydrolase
AMET_RS01635	COG3246	L-lysine catabolic process to acetate
AMET_RS01640	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AMET_RS01650	COG1494	fructose-1,6-bisphosphatase
AMET_RS01655	COG1494	fructose-1,6-bisphosphatase
AMET_RS01660	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AMET_RS01665	COG0254	rRNA binding
AMET_RS01670	COG1435	thymidine kinase activity
AMET_RS01695	COG2890	protein-(glutamine-N5) methyltransferase activity
AMET_RS01700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AMET_RS01710	COG1716	ATPase activity
AMET_RS01720	COG0768	penicillin binding
AMET_RS01725	COG0009	L-threonylcarbamoyladenylate synthase
AMET_RS01735	COG0698	ribose 5-phosphate isomerase
AMET_RS01740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AMET_RS01745	COG0590	tRNA wobble adenosine to inosine editing
AMET_RS01750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMET_RS01755	COG0733	neurotransmitter:sodium symporter activity
AMET_RS01760	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AMET_RS01790	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AMET_RS01795	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMET_RS01800	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AMET_RS01805	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AMET_RS01810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AMET_RS01815	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AMET_RS01835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AMET_RS01840	COG2385	sporulation resulting in formation of a cellular spore
AMET_RS01860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMET_RS01865	COG1609	Transcriptional regulator
AMET_RS01870	COG1077	Cell shape determining protein MreB Mrl
AMET_RS01875	COG1136	(ABC) transporter
AMET_RS01885	COG1136	(ABC) transporter
AMET_RS01885	COG0577	efflux transmembrane transporter activity
AMET_RS01890	COG4786	Flagellar basal body rod
AMET_RS01905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMET_RS01920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AMET_RS01975	COG2842	Transposition protein
AMET_RS02015	COG1191	sigma factor activity
AMET_RS02060	COG3409	Peptidoglycan-binding domain 1 protein
AMET_RS02060	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMET_RS02230	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AMET_RS02235	COG3949	Membrane
AMET_RS02240	COG0277	FAD linked oxidase domain protein
AMET_RS02265	COG0484	heat shock protein binding
AMET_RS02275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMET_RS02275	COG0519	Catalyzes the synthesis of GMP from XMP
AMET_RS02280	COG1609	Transcriptional regulator
AMET_RS02285	COG1879	ABC-type sugar transport system periplasmic component
AMET_RS02290	COG1129	ABC transporter
AMET_RS02295	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMET_RS02305	COG0673	inositol 2-dehydrogenase activity
AMET_RS02325	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AMET_RS02345	COG0840	transmembrane signaling receptor activity
AMET_RS02375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMET_RS02375	COG2080	2 iron, 2 sulfur cluster binding
AMET_RS02390	COG4948	Mandelate Racemase Muconate Lactonizing
AMET_RS02395	COG1619	proteins homologs of microcin C7 resistance protein MccF
AMET_RS02410	COG1053	succinate dehydrogenase
AMET_RS02410	COG3976	FMN-binding domain protein
AMET_RS02415	COG1691	(AIR) carboxylase
AMET_RS02420	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AMET_RS02425	COG1606	tRNA processing
AMET_RS02430	COG4187	Peptidase family M20/M25/M40
AMET_RS02435	COG0045	succinate-CoA ligase (ADP-forming) activity
AMET_RS02440	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AMET_RS02460	COG2197	response regulator
AMET_RS02495	COG1361	Conserved repeat domain
AMET_RS02515	COG1414	Transcriptional regulator
AMET_RS02520	COG2610	gluconate transmembrane transporter activity
AMET_RS02525	COG0129	dihydroxy-acid dehydratase activity
AMET_RS02530	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMET_RS02535	COG0436	Aminotransferase
AMET_RS02545	COG1882	Formate acetyltransferase
AMET_RS02550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AMET_RS02570	COG0753	catalase activity
AMET_RS02570	COG0693	protein deglycase activity
AMET_RS02585	COG0697	spore germination
AMET_RS02590	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AMET_RS02595	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AMET_RS02600	COG3639	organic phosphonate transmembrane transporter activity
AMET_RS02610	COG2884	Cell division ATP-binding protein ftsE
AMET_RS02620	COG0326	Molecular chaperone. Has ATPase activity
AMET_RS02640	COG1122	ATPase activity
AMET_RS02670	COG0406	alpha-ribazole phosphatase activity
AMET_RS02675	COG0393	Putative heavy-metal-binding
AMET_RS02705	COG3875	lactate racemase activity
AMET_RS02710	COG3949	Membrane
AMET_RS02730	COG0737	Belongs to the 5'-nucleotidase family
AMET_RS02740	COG2207	Transcriptional regulator
AMET_RS02750	COG0745	RESPONSE REGULATOR receiver
AMET_RS02755	COG3850	Histidine kinase
AMET_RS02755	COG5002	protein histidine kinase activity
AMET_RS02770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMET_RS02780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMET_RS02780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMET_RS02785	COG1802	Transcriptional regulator
AMET_RS02790	COG1063	alcohol dehydrogenase
AMET_RS02795	COG0246	Mannitol dehydrogenase
AMET_RS02800	COG2721	sulfolactate sulfo-lyase activity
AMET_RS02805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMET_RS02810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMET_RS02820	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMET_RS02825	COG0584	glycerophosphoryl diester phosphodiesterase
AMET_RS02835	COG1285	pathogenesis
AMET_RS02840	COG3875	lactate racemase activity
AMET_RS02845	COG4492	Belongs to the UPF0735 family
AMET_RS02850	COG0460	homoserine dehydrogenase
AMET_RS02855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMET_RS02860	COG0083	homoserine kinase activity
AMET_RS02865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMET_RS02870	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AMET_RS02875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AMET_RS02880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AMET_RS02885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMET_RS02890	COG0131	Imidazoleglycerol-phosphate dehydratase
AMET_RS02895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AMET_RS02900	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AMET_RS02905	COG0107	imidazoleglycerol-phosphate synthase activity
AMET_RS02910	COG0140	phosphoribosyl-ATP diphosphatase activity
AMET_RS02910	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AMET_RS02915	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AMET_RS02920	COG0733	neurotransmitter:sodium symporter activity
AMET_RS02925	COG3290	protein histidine kinase activity
AMET_RS02925	COG0840	transmembrane signaling receptor activity
AMET_RS02940	COG0708	Exodeoxyribonuclease III
AMET_RS02945	COG1609	Transcriptional regulator
AMET_RS02950	COG1129	ABC transporter
AMET_RS02965	COG1063	alcohol dehydrogenase
AMET_RS02970	COG1070	Carbohydrate kinase
AMET_RS02975	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AMET_RS02985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AMET_RS03015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMET_RS03030	COG0745	RESPONSE REGULATOR receiver
AMET_RS03050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMET_RS03055	COG1766	The M ring may be actively involved in energy transduction
AMET_RS03060	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AMET_RS03070	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AMET_RS03075	COG1776	CheC inhibitor of MCP methylation
AMET_RS03075	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AMET_RS03080	COG2201	protein-glutamate methylesterase activity
AMET_RS03085	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AMET_RS03095	COG4978	Transcriptional regulator
AMET_RS03095	COG0789	Transcriptional regulator
AMET_RS03100	COG3279	Response regulator of the LytR AlgR family
AMET_RS03210	COG2358	TRAP transporter, solute receptor (TAXI family
AMET_RS03215	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AMET_RS03220	COG0287	Prephenate dehydrogenase
AMET_RS03225	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AMET_RS03230	COG0077	Prephenate dehydratase
AMET_RS03230	COG1605	Chorismate mutase
AMET_RS03235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AMET_RS03240	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AMET_RS03245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMET_RS03250	COG0165	Argininosuccinate lyase
AMET_RS03255	COG0137	argininosuccinate synthase activity
AMET_RS03265	COG5002	protein histidine kinase activity
AMET_RS03270	COG0745	RESPONSE REGULATOR receiver
AMET_RS03290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMET_RS03295	COG1288	antiporter activity
AMET_RS03300	COG1533	DNA photolyase activity
AMET_RS03310	COG4656	Part of a membrane complex involved in electron transport
AMET_RS03315	COG5275	peptidyl-tyrosine sulfation
AMET_RS03315	COG0252	asparaginase activity
AMET_RS03325	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AMET_RS03330	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AMET_RS03335	COG5275	peptidyl-tyrosine sulfation
AMET_RS03335	COG0252	asparaginase activity
AMET_RS03340	COG0252	asparaginase activity
AMET_RS03340	COG5275	peptidyl-tyrosine sulfation
AMET_RS03355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AMET_RS03360	COG0442	prolyl-tRNA aminoacylation
AMET_RS03365	COG0840	transmembrane signaling receptor activity
AMET_RS03375	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMET_RS03380	COG2379	hydroxypyruvate reductase
AMET_RS03405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMET_RS03415	COG2508	Transcriptional regulator
AMET_RS03425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AMET_RS03430	COG1304	FMN binding
AMET_RS03435	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AMET_RS03445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMET_RS03455	COG1757	Na H antiporter
AMET_RS03470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AMET_RS03475	COG0531	amino acid
AMET_RS03485	COG3290	protein histidine kinase activity
AMET_RS03485	COG3829	transcription factor binding
AMET_RS03495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMET_RS03495	COG1522	sequence-specific DNA binding
AMET_RS03500	COG2313	pseudouridylate synthase activity
AMET_RS03505	COG5000	phosphorelay sensor kinase activity
AMET_RS03510	COG3906	Belongs to the UPF0473 family
AMET_RS03520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMET_RS03525	COG0745	RESPONSE REGULATOR receiver
AMET_RS03530	COG5002	protein histidine kinase activity
AMET_RS03560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMET_RS03585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AMET_RS03610	COG1256	bacterial-type flagellum assembly
AMET_RS03610	COG4786	Flagellar basal body rod
AMET_RS03615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AMET_RS03625	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AMET_RS03630	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AMET_RS03715	COG1773	rubredoxin
AMET_RS03715	COG1592	Rubrerythrin
AMET_RS03720	COG3437	response regulator, receiver
AMET_RS03720	COG2770	Histidine kinase
AMET_RS03745	COG3314	Sporulation integral membrane protein YlbJ
AMET_RS03755	COG3976	FMN-binding domain protein
AMET_RS03755	COG1053	succinate dehydrogenase
AMET_RS03755	COG0431	NADPH-dependent FMN reductase
AMET_RS03760	COG0778	Nitroreductase
AMET_RS03765	COG1307	EDD domain protein, DegV family
AMET_RS03780	COG0277	FAD linked oxidase domain protein
AMET_RS03785	COG2086	electron transfer activity
AMET_RS03790	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AMET_RS03795	COG0786	glutamate:sodium symporter activity
AMET_RS03805	COG0454	-acetyltransferase
AMET_RS03805	COG0456	acetyltransferase
AMET_RS03815	COG1639	'signal transduction protein
AMET_RS03830	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AMET_RS03840	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AMET_RS03850	COG2358	TRAP transporter, solute receptor (TAXI family
AMET_RS03870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMET_RS03880	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AMET_RS03885	COG1516	flagellar protein fliS
AMET_RS03895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AMET_RS03905	COG0653	protein targeting
AMET_RS03910	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AMET_RS03930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AMET_RS03940	COG1368	sulfuric ester hydrolase activity
AMET_RS03945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMET_RS03950	COG2183	response to ionizing radiation
AMET_RS03955	COG2271	Major facilitator Superfamily
AMET_RS03965	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AMET_RS03970	COG0802	atpase or kinase
AMET_RS03975	COG1214	PFAM Peptidase M22, glycoprotease
AMET_RS03980	COG0456	acetyltransferase
AMET_RS03995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AMET_RS04000	COG0488	(ABC) transporter
AMET_RS04005	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AMET_RS04015	COG2221	Nitrite and sulphite reductase 4Fe-4S
AMET_RS04035	COG1620	l-lactate permease
AMET_RS04040	COG2186	Transcriptional regulator
AMET_RS04045	COG2086	electron transfer activity
AMET_RS04050	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AMET_RS04055	COG0277	FAD linked oxidase domain protein
AMET_RS04060	COG0011	TIGRFAM Protein of
AMET_RS04065	COG1131	(ABC) transporter
AMET_RS04075	COG1349	DNA-binding transcription factor activity
AMET_RS04085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMET_RS04085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMET_RS04085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMET_RS04095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMET_RS04110	COG1811	Na channel or pump
AMET_RS04115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AMET_RS04120	COG0459	protein refolding
AMET_RS04125	COG0582	viral genome integration into host DNA
AMET_RS04185	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AMET_RS04195	COG0732	type I restriction modification DNA specificity domain
AMET_RS04275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMET_RS04305	COG0756	dUTP diphosphatase activity
AMET_RS04310	COG0697	spore germination
AMET_RS04330	COG4974	Belongs to the 'phage' integrase family
AMET_RS04365	COG1396	sequence-specific DNA binding
AMET_RS04375	COG2207	Transcriptional regulator
AMET_RS04380	COG0697	spore germination
AMET_RS04385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMET_RS04390	COG0561	phosphatase activity
AMET_RS04395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMET_RS04405	COG3842	ATPase activity
AMET_RS04410	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AMET_RS04420	COG1175	transmembrane transport
AMET_RS04425	COG0395	ABC-type sugar transport system, permease component
AMET_RS04435	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AMET_RS04440	COG1028	Short-chain dehydrogenase reductase Sdr
AMET_RS04445	COG1609	Transcriptional regulator
AMET_RS04460	COG5577	PFAM Coat F domain
AMET_RS04485	COG0517	IMP dehydrogenase activity
AMET_RS04485	COG0516	GMP reductase activity
AMET_RS04490	COG0519	Catalyzes the synthesis of GMP from XMP
AMET_RS04490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMET_RS04505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AMET_RS04515	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMET_RS04515	COG0519	Catalyzes the synthesis of GMP from XMP
AMET_RS04520	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AMET_RS04525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AMET_RS04530	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMET_RS04535	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMET_RS04540	COG0047	phosphoribosylformylglycinamidine synthase activity
AMET_RS04545	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMET_RS04550	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AMET_RS04555	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AMET_RS04560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AMET_RS04565	COG0138	bifunctional purine biosynthesis protein purh
AMET_RS04570	COG0151	Belongs to the GarS family
AMET_RS04590	COG1464	Belongs to the NlpA lipoprotein family
AMET_RS04595	COG2011	ABC-type metal ion transport system permease component
AMET_RS04600	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMET_RS04605	COG4496	protein, YerC YecD
AMET_RS04610	COG0527	aspartate kinase activity
AMET_RS04630	COG0210	DNA helicase
AMET_RS04635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMET_RS04645	COG1592	Rubrerythrin
AMET_RS04670	COG3069	C4-dicarboxylate transmembrane transporter activity
AMET_RS04685	COG2247	cell wall binding repeat
AMET_RS04685	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMET_RS04690	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AMET_RS04695	COG5401	PFAM Sporulation and spore germination
AMET_RS04700	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AMET_RS04710	COG0622	Phosphoesterase
AMET_RS04760	COG1361	Conserved repeat domain
AMET_RS04760	COG2911	Protein conserved in bacteria
AMET_RS04760	COG3266	domain, Protein
AMET_RS04790	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMET_RS04800	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMET_RS04805	COG0647	UMP catabolic process
AMET_RS04815	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMET_RS04825	COG1285	pathogenesis
AMET_RS04830	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AMET_RS04840	COG0583	DNA-binding transcription factor activity
AMET_RS04865	COG0798	PFAM Bile acid sodium symporter
AMET_RS04890	COG0746	molybdenum cofactor guanylyltransferase activity
AMET_RS04895	COG0243	molybdopterin cofactor binding
AMET_RS04900	COG0437	4 iron, 4 sulfur cluster binding
AMET_RS04915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMET_RS04925	COG0303	'Molybdopterin
AMET_RS04935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMET_RS04940	COG0805	protein transport
AMET_RS04945	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AMET_RS04950	COG1185	polyribonucleotide nucleotidyltransferase activity
AMET_RS04965	COG3973	AAA domain
AMET_RS04975	COG1185	polyribonucleotide nucleotidyltransferase activity
AMET_RS04980	COG0494	nUDIX hydrolase
AMET_RS04995	COG0659	secondary active sulfate transmembrane transporter activity
AMET_RS05005	COG5002	protein histidine kinase activity
AMET_RS05010	COG2198	Histidine kinase
AMET_RS05010	COG0784	Response regulator, receiver
AMET_RS05010	COG5002	protein histidine kinase activity
AMET_RS05020	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AMET_RS05025	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AMET_RS05040	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMET_RS05040	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMET_RS05045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AMET_RS05080	COG1316	TRANSCRIPTIONal
AMET_RS05085	COG2208	phosphoserine phosphatase activity
AMET_RS05210	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AMET_RS05215	COG3344	reverse transcriptase
AMET_RS05245	COG1164	Oligoendopeptidase f
AMET_RS05250	COG3153	acetyltransferase
AMET_RS05250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMET_RS05260	COG0544	peptidyl-prolyl cis-trans isomerase activity
AMET_RS05265	COG0740	serine-type endopeptidase activity
AMET_RS05270	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AMET_RS05275	COG2059	Chromate
AMET_RS05280	COG2059	Chromate
AMET_RS05285	COG0470	DNA polymerase III
AMET_RS05285	COG1067	ATP-dependent peptidase activity
AMET_RS05290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AMET_RS05295	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AMET_RS05300	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AMET_RS05305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AMET_RS05320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AMET_RS05320	COG0512	Glutamine amidotransferase of anthranilate synthase
AMET_RS05325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AMET_RS05330	COG0134	indole-3-glycerol-phosphate synthase activity
AMET_RS05335	COG0135	phosphoribosylanthranilate isomerase activity
AMET_RS05340	COG0133	tryptophan synthase activity
AMET_RS05345	COG0159	tryptophan synthase activity
AMET_RS05350	COG1773	rubredoxin
AMET_RS05355	COG2309	aminopeptidase activity
AMET_RS05370	COG2364	Membrane
AMET_RS05395	COG2217	Heavy metal translocating P-type atpase
AMET_RS05420	COG0745	RESPONSE REGULATOR receiver
AMET_RS05425	COG2205	protein histidine kinase activity
AMET_RS05445	COG0248	Ppx GppA phosphatase
AMET_RS05475	COG1846	Transcriptional regulator
AMET_RS05480	COG0534	Mate efflux family protein
AMET_RS05505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMET_RS05510	COG4166	transmembrane transport
AMET_RS05515	COG0444	Belongs to the ABC transporter superfamily
AMET_RS05520	COG4608	Belongs to the ABC transporter superfamily
AMET_RS05525	COG0534	Mate efflux family protein
AMET_RS05530	COG3608	succinylglutamate desuccinylase aspartoacylase
AMET_RS05580	COG0601	transmembrane transport
AMET_RS05590	COG0444	Belongs to the ABC transporter superfamily
AMET_RS05600	COG0534	Mate efflux family protein
AMET_RS05640	COG1320	monovalent cation:proton antiporter activity
AMET_RS05660	COG1006	Multisubunit Na H antiporter MnhC subunit
AMET_RS05670	COG2188	Transcriptional regulator
AMET_RS05675	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
AMET_RS05685	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
AMET_RS05695	COG3627	carbon phosphorus lyase activity
AMET_RS05700	COG4107	phosphonate C-P lyase system protein PhnK
AMET_RS05705	COG3454	Phosphonate metabolism
AMET_RS05710	COG4778	phosphonate C-P lyase system protein PhnL
AMET_RS05720	COG3639	organic phosphonate transmembrane transporter activity
AMET_RS05725	COG3639	organic phosphonate transmembrane transporter activity
AMET_RS05730	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AMET_RS05745	COG2199	diguanylate cyclase activity
AMET_RS05745	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AMET_RS05755	COG3706	GGDEF domain
AMET_RS05760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMET_RS05775	COG1924	4 iron, 4 sulfur cluster binding
AMET_RS05785	COG1121	(ABC) transporter
AMET_RS05790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMET_RS05805	COG1151	hydroxylamine reductase activity
AMET_RS05850	COG2340	Cysteine-rich secretory protein family
AMET_RS05855	COG0840	transmembrane signaling receptor activity
AMET_RS05865	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AMET_RS05875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AMET_RS05880	COG1473	amidohydrolase
AMET_RS05885	COG1414	Transcriptional regulator
AMET_RS05890	COG0006	proline dipeptidase activity
AMET_RS05910	COG1013	pyruvate-flavodoxin oxidoreductase activity
AMET_RS05915	COG0674	pyruvate-flavodoxin oxidoreductase activity
AMET_RS05940	COG1285	pathogenesis
AMET_RS05945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AMET_RS05970	COG0534	Mate efflux family protein
AMET_RS05975	COG1013	pyruvate-flavodoxin oxidoreductase activity
AMET_RS05980	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AMET_RS05980	COG0674	pyruvate-flavodoxin oxidoreductase activity
AMET_RS06015	COG2996	Protein conserved in bacteria
AMET_RS06035	COG1592	Rubrerythrin
AMET_RS06035	COG1773	rubredoxin
AMET_RS06045	COG4242	Belongs to the peptidase S51 family
AMET_RS06065	COG0701	Predicted permease
AMET_RS06085	COG1477	protein flavinylation
AMET_RS06095	COG1376	ErfK ybiS ycfS ynhG family protein
AMET_RS06100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AMET_RS06115	COG1126	abc transporter atp-binding protein
AMET_RS06130	COG1285	pathogenesis
AMET_RS06140	COG0352	thiamine-phosphate diphosphorylase activity
AMET_RS06150	COG0352	thiamine-phosphate diphosphorylase activity
AMET_RS06155	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AMET_RS06160	COG0351	phosphomethylpyrimidine kinase
AMET_RS06160	COG0352	thiamine-phosphate diphosphorylase activity
AMET_RS06185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMET_RS06190	COG2208	phosphoserine phosphatase activity
AMET_RS06195	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AMET_RS06195	COG2199	diguanylate cyclase activity
AMET_RS06200	COG3711	transcriptional antiterminator
AMET_RS06205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMET_RS06210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMET_RS06215	COG1414	Transcriptional regulator
AMET_RS06220	COG0800	Aldolase
AMET_RS06235	COG2188	Transcriptional regulator
AMET_RS06245	COG3181	Tripartite tricarboxylate transporter family receptor
AMET_RS06255	COG0129	dihydroxy-acid dehydratase activity
AMET_RS06280	COG0398	Pfam SNARE associated Golgi protein
AMET_RS06295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMET_RS06330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AMET_RS06335	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AMET_RS06350	COG0697	spore germination
AMET_RS06365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMET_RS06375	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMET_RS06380	COG1904	glucuronate isomerase
AMET_RS06385	COG1312	Catalyzes the dehydration of D-mannonate
AMET_RS06390	COG0246	Mannitol dehydrogenase
AMET_RS06400	COG1116	anion transmembrane transporter activity
AMET_RS06405	COG1278	Cold shock
AMET_RS06435	COG1472	Belongs to the glycosyl hydrolase 3 family
AMET_RS06445	COG4565	transcriptional regulatory protein
AMET_RS06450	COG0281	malic enzyme
AMET_RS06455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMET_RS06510	COG0728	peptidoglycan biosynthetic process
AMET_RS06520	COG0473	3-isopropylmalate dehydrogenase activity
AMET_RS06525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMET_RS06530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMET_RS06540	COG1725	Transcriptional regulator
AMET_RS06545	COG1131	(ABC) transporter
AMET_RS06555	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AMET_RS06560	COG3639	organic phosphonate transmembrane transporter activity
AMET_RS06565	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AMET_RS06575	COG0243	molybdopterin cofactor binding
AMET_RS06580	COG0437	4 iron, 4 sulfur cluster binding
AMET_RS06585	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMET_RS06595	COG2081	HI0933 family
AMET_RS06600	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AMET_RS06610	COG2210	Belongs to the sulfur carrier protein TusA family
AMET_RS06615	COG1309	transcriptional regulator
AMET_RS06630	COG4536	flavin adenine dinucleotide binding
AMET_RS06640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMET_RS06650	COG0561	phosphatase activity
AMET_RS06655	COG1053	succinate dehydrogenase
AMET_RS06660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMET_RS06685	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AMET_RS06695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMET_RS06700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMET_RS06715	COG3872	metal-dependent enzyme
AMET_RS06740	COG0772	Belongs to the SEDS family
AMET_RS06745	COG2239	Acts as a magnesium transporter
AMET_RS06755	COG2959	enzyme of heme biosynthesis
AMET_RS06790	COG0166	Belongs to the GPI family
AMET_RS06795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AMET_RS06800	COG3275	phosphorelay sensor kinase activity
AMET_RS06805	COG3279	Response regulator of the LytR AlgR family
AMET_RS06815	COG1966	Carbon starvation protein
AMET_RS06825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMET_RS06830	COG2244	polysaccharide biosynthetic process
AMET_RS06880	COG3976	FMN-binding domain protein
AMET_RS06880	COG1053	succinate dehydrogenase
AMET_RS06900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMET_RS06910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMET_RS06915	COG0525	valine-tRNA ligase activity
AMET_RS06920	COG0285	dihydrofolate synthase activity
AMET_RS06930	COG4974	Belongs to the 'phage' integrase family
AMET_RS06950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AMET_RS06980	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AMET_RS07005	COG0693	protein deglycase activity
AMET_RS07015	COG1357	PFAM Pentapeptide repeats (8 copies)
AMET_RS07020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMET_RS07030	COG2720	vancomycin resistance protein
AMET_RS07055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMET_RS07075	COG0346	lactoylglutathione lyase activity
AMET_RS07080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMET_RS07100	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMET_RS07105	COG4335	DNA alkylation repair
AMET_RS07130	COG1151	hydroxylamine reductase activity
AMET_RS07135	COG0589	response to stress
AMET_RS07145	COG0840	transmembrane signaling receptor activity
AMET_RS07155	COG0488	(ABC) transporter
AMET_RS07190	COG5002	protein histidine kinase activity
AMET_RS07195	COG1136	(ABC) transporter
AMET_RS07200	COG0577	efflux transmembrane transporter activity
AMET_RS07215	COG1342	Belongs to the UPF0251 family
AMET_RS07245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMET_RS07250	COG0840	transmembrane signaling receptor activity
AMET_RS07275	COG4977	sequence-specific DNA binding
AMET_RS07315	COG1846	Transcriptional regulator
AMET_RS07320	COG0003	Pfam Anion-transporting ATPase
AMET_RS07380	COG2311	Membrane
AMET_RS07425	COG3559	Exporter of polyketide antibiotics
AMET_RS07430	COG1131	(ABC) transporter
AMET_RS07435	COG1309	transcriptional regulator
AMET_RS07445	COG2207	Transcriptional regulator
AMET_RS07445	COG3708	Transcriptional regulator
AMET_RS07450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMET_RS07455	COG0745	RESPONSE REGULATOR receiver
AMET_RS07460	COG5002	protein histidine kinase activity
AMET_RS07470	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AMET_RS07475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMET_RS07490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMET_RS07500	COG0456	acetyltransferase
AMET_RS07520	COG5002	protein histidine kinase activity
AMET_RS07550	COG0574	Belongs to the PEP-utilizing enzyme family
AMET_RS07550	COG3848	Pyruvate phosphate dikinase
AMET_RS07555	COG2814	Major facilitator Superfamily
AMET_RS07575	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMET_RS07575	COG4124	Belongs to the glycosyl hydrolase 26 family
AMET_RS07590	COG3266	domain, Protein
AMET_RS07590	COG2911	Protein conserved in bacteria
AMET_RS07590	COG1361	Conserved repeat domain
AMET_RS07600	COG0488	(ABC) transporter
AMET_RS07610	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AMET_RS07625	COG1132	(ABC) transporter
AMET_RS07635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMET_RS07665	COG0488	(ABC) transporter
AMET_RS07670	COG0577	efflux transmembrane transporter activity
AMET_RS07675	COG1136	(ABC) transporter
AMET_RS07680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMET_RS07685	COG4585	Histidine kinase
AMET_RS07695	COG2197	response regulator
AMET_RS07700	COG2311	Membrane
AMET_RS07710	COG3314	Sporulation integral membrane protein YlbJ
AMET_RS07715	COG1695	Transcriptional regulator
AMET_RS07740	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AMET_RS07765	COG0840	transmembrane signaling receptor activity
AMET_RS07785	COG0346	lactoylglutathione lyase activity
AMET_RS07790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AMET_RS07820	COG0390	transport system, permease component
AMET_RS07830	COG1695	Transcriptional regulator
AMET_RS07855	COG4974	Belongs to the 'phage' integrase family
AMET_RS07895	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AMET_RS07945	COG3328	transposase activity
AMET_RS07955	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AMET_RS07970	COG1283	sodium-dependent phosphate transmembrane transporter activity
AMET_RS07975	COG0436	Aminotransferase
AMET_RS07980	COG0726	polysaccharide deacetylase
AMET_RS07995	COG1956	GAF domain-containing protein
AMET_RS08000	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AMET_RS08015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMET_RS08025	COG2226	methyltransferase
AMET_RS08030	COG1278	Cold shock
AMET_RS08035	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AMET_RS08065	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMET_RS08080	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AMET_RS08085	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AMET_RS08090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AMET_RS08095	COG0569	domain protein
AMET_RS08100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMET_RS08105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMET_RS08110	COG0072	phenylalanine-tRNA ligase activity
AMET_RS08110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMET_RS08120	COG0826	peptidase U32
AMET_RS08130	COG1121	(ABC) transporter
AMET_RS08135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMET_RS08140	COG0803	Belongs to the bacterial solute-binding protein 9 family
AMET_RS08155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMET_RS08160	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMET_RS08180	COG0398	Pfam SNARE associated Golgi protein
AMET_RS08195	COG1454	alcohol dehydrogenase
AMET_RS08215	COG2878	Part of a membrane complex involved in electron transport
AMET_RS08245	COG1518	maintenance of DNA repeat elements
AMET_RS08250	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AMET_RS08260	COG0039	L-malate dehydrogenase activity
AMET_RS08265	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AMET_RS08275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMET_RS08280	COG0765	amino acid transport
AMET_RS08285	COG1126	abc transporter atp-binding protein
AMET_RS08290	COG1013	pyruvate-flavodoxin oxidoreductase activity
AMET_RS08290	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AMET_RS08290	COG0674	pyruvate-flavodoxin oxidoreductase activity
AMET_RS08290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMET_RS08300	COG0058	SHG alpha-glucan phosphorylase activity
AMET_RS08315	COG1595	DNA-templated transcription, initiation
AMET_RS08340	COG1136	(ABC) transporter
AMET_RS08345	COG0577	efflux transmembrane transporter activity
AMET_RS08355	COG0745	RESPONSE REGULATOR receiver
AMET_RS08360	COG2205	protein histidine kinase activity
AMET_RS08370	COG2878	Part of a membrane complex involved in electron transport
AMET_RS08375	COG1408	metallophosphoesterase
AMET_RS08385	COG0426	domain, Protein
AMET_RS08390	COG0456	acetyltransferase
AMET_RS08400	COG0604	alcohol dehydrogenase
AMET_RS08420	COG1058	Belongs to the CinA family
AMET_RS08420	COG1546	Belongs to the CinA family
AMET_RS08430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMET_RS08435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AMET_RS08440	COG3616	Alanine racemase, N-terminal domain
AMET_RS08445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMET_RS08450	COG1217	gtp-binding protein TYPA
AMET_RS08460	COG1193	negative regulation of DNA recombination
AMET_RS08465	COG1683	Conserved Protein
AMET_RS08470	COG0018	arginyl-trna synthetase
AMET_RS08475	COG0840	transmembrane signaling receptor activity
AMET_RS08490	COG0534	Mate efflux family protein
AMET_RS08510	COG1032	radical SAM domain protein
AMET_RS08530	COG0280	phosphate acetyltransferase
AMET_RS08645	COG0737	Belongs to the 5'-nucleotidase family
AMET_RS08650	COG3842	ATPase activity
AMET_RS08655	COG1175	transmembrane transport
AMET_RS08660	COG0395	ABC-type sugar transport system, permease component
AMET_RS08665	COG1653	transport
AMET_RS08670	COG1185	polyribonucleotide nucleotidyltransferase activity
AMET_RS08715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMET_RS08720	COG2333	competence protein COMEC
AMET_RS08720	COG0658	competence protein
AMET_RS08745	COG2304	oxidoreductase activity
AMET_RS08755	COG1484	DNA-dependent DNA replication
AMET_RS08760	COG2390	Transcriptional regulator
AMET_RS08760	COG4584	PFAM Integrase catalytic
AMET_RS08770	COG2226	methyltransferase
AMET_RS08775	COG0346	lactoylglutathione lyase activity
AMET_RS08830	COG0745	RESPONSE REGULATOR receiver
AMET_RS08835	COG5002	protein histidine kinase activity
AMET_RS08865	COG4221	oxidoreductase activity
AMET_RS08870	COG1408	metallophosphoesterase
AMET_RS08875	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMET_RS08890	COG3385	transposase activity
AMET_RS08955	COG1595	DNA-templated transcription, initiation
AMET_RS08980	COG1595	DNA-templated transcription, initiation
AMET_RS09090	COG0798	PFAM Bile acid sodium symporter
AMET_RS09115	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AMET_RS09130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMET_RS09145	COG0640	Transcriptional regulator
AMET_RS09170	COG1131	(ABC) transporter
AMET_RS09195	COG1595	DNA-templated transcription, initiation
AMET_RS09230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMET_RS09285	COG1846	Transcriptional regulator
AMET_RS09300	COG0601	transmembrane transport
AMET_RS09305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMET_RS09310	COG0444	Belongs to the ABC transporter superfamily
AMET_RS09315	COG4608	Belongs to the ABC transporter superfamily
AMET_RS09320	COG0747	negative chemotaxis
AMET_RS09330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMET_RS09365	COG1595	DNA-templated transcription, initiation
AMET_RS09405	COG3620	sequence-specific DNA binding
AMET_RS09425	COG3173	Aminoglycoside phosphotransferase
AMET_RS09435	COG1309	transcriptional regulator
AMET_RS09460	COG1309	transcriptional regulator
AMET_RS09465	COG3848	Pyruvate phosphate dikinase
AMET_RS09465	COG0574	Belongs to the PEP-utilizing enzyme family
AMET_RS09470	COG0745	RESPONSE REGULATOR receiver
AMET_RS09530	COG2842	Transposition protein
AMET_RS09570	COG1191	sigma factor activity
AMET_RS09615	COG3409	Peptidoglycan-binding domain 1 protein
AMET_RS09615	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMET_RS09795	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMET_RS09815	COG1882	Formate acetyltransferase
AMET_RS09820	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AMET_RS09845	COG0745	RESPONSE REGULATOR receiver
AMET_RS09890	COG1131	(ABC) transporter
AMET_RS09905	COG0601	transmembrane transport
AMET_RS09915	COG0747	negative chemotaxis
AMET_RS09920	COG0444	Belongs to the ABC transporter superfamily
AMET_RS09925	COG4608	Belongs to the ABC transporter superfamily
AMET_RS09935	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMET_RS09945	COG0640	Transcriptional regulator
AMET_RS09955	COG1151	hydroxylamine reductase activity
AMET_RS09965	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AMET_RS09970	COG3404	Formiminotransferase-cyclodeaminase
AMET_RS09975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMET_RS09990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMET_RS10020	COG0509	glycine decarboxylation via glycine cleavage system
AMET_RS10055	COG0601	transmembrane transport
AMET_RS10060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMET_RS10065	COG1136	(ABC) transporter
AMET_RS10065	COG0577	efflux transmembrane transporter activity
AMET_RS10085	COG0739	heme binding
AMET_RS10085	COG1196	nuclear chromosome segregation
AMET_RS10085	COG0741	lytic transglycosylase activity
AMET_RS10105	COG0601	transmembrane transport
AMET_RS10110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMET_RS10115	COG0444	Belongs to the ABC transporter superfamily
AMET_RS10145	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AMET_RS10155	COG0534	Mate efflux family protein
AMET_RS10170	COG0739	heme binding
AMET_RS10170	COG0741	lytic transglycosylase activity
AMET_RS10170	COG1196	nuclear chromosome segregation
AMET_RS10175	COG0662	Cupin 2, conserved barrel domain protein
AMET_RS10180	COG3290	protein histidine kinase activity
AMET_RS10180	COG3829	transcription factor binding
AMET_RS10185	COG0747	negative chemotaxis
AMET_RS10190	COG0601	transmembrane transport
AMET_RS10195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMET_RS10200	COG0444	Belongs to the ABC transporter superfamily
AMET_RS10205	COG4608	Belongs to the ABC transporter superfamily
AMET_RS10215	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AMET_RS10220	COG2362	D-Aminopeptidase
AMET_RS10225	COG0784	Response regulator, receiver
AMET_RS10225	COG2205	protein histidine kinase activity
AMET_RS10225	COG2198	Histidine kinase
AMET_RS10230	COG1309	transcriptional regulator
AMET_RS10240	COG1846	Transcriptional regulator
AMET_RS10275	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AMET_RS10280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMET_RS10305	COG5012	cobalamin binding
AMET_RS10320	COG3314	Sporulation integral membrane protein YlbJ
AMET_RS10335	COG5012	cobalamin binding
AMET_RS10340	COG2211	Major facilitator Superfamily
AMET_RS10350	COG5012	cobalamin binding
AMET_RS10355	COG2188	Transcriptional regulator
AMET_RS10390	COG3655	Transcriptional regulator
AMET_RS10410	COG3655	Transcriptional regulator
AMET_RS10460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMET_RS10475	COG1404	Belongs to the peptidase S8 family
AMET_RS10595	COG0202	RNA polymerase activity
AMET_RS10620	COG1595	DNA-templated transcription, initiation
AMET_RS10645	COG0668	transmembrane transport
AMET_RS10650	COG1418	mRNA catabolic process
AMET_RS10665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMET_RS10670	COG0302	gtp cyclohydrolase
AMET_RS10675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMET_RS10680	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AMET_RS10685	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AMET_RS10690	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AMET_RS10715	COG2268	Band 7 protein
AMET_RS10720	COG0124	histidyl-tRNA synthetase
AMET_RS10725	COG3706	GGDEF domain
AMET_RS10730	COG3885	ferrous iron binding
AMET_RS10730	COG2078	PFAM AMMECR1 domain protein
AMET_RS10740	COG1132	(ABC) transporter
AMET_RS10760	COG0706	membrane insertase activity
AMET_RS10765	COG0628	permease
AMET_RS10770	COG2357	RelA SpoT domain protein
AMET_RS10775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMET_RS10780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMET_RS10840	COG1518	maintenance of DNA repeat elements
AMET_RS10845	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AMET_RS10850	COG0436	Aminotransferase
AMET_RS10870	COG1361	Conserved repeat domain
AMET_RS10875	COG0210	DNA helicase
AMET_RS10895	COG0301	tRNA thio-modification
AMET_RS10900	COG0315	cyclic pyranopterin monophosphate synthase activity
AMET_RS10905	COG0521	Mo-molybdopterin cofactor biosynthetic process
AMET_RS10910	COG1950	PFAM Membrane protein of
AMET_RS10915	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AMET_RS10930	COG2172	sigma factor antagonist activity
AMET_RS10960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMET_RS10985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AMET_RS11005	COG1739	Uncharacterized protein family UPF0029
AMET_RS11020	COG0730	response to heat
AMET_RS11025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMET_RS11030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AMET_RS11035	COG0217	transcriptional regulatory protein
AMET_RS11045	COG4974	Belongs to the 'phage' integrase family
AMET_RS11145	COG1476	TRANSCRIPTIONal
AMET_RS11155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMET_RS11170	COG0456	acetyltransferase
AMET_RS11225	COG0217	transcriptional regulatory protein
AMET_RS11260	COG2205	protein histidine kinase activity
AMET_RS11260	COG0784	Response regulator, receiver
AMET_RS11265	COG4656	Part of a membrane complex involved in electron transport
AMET_RS11270	COG4658	electron transport chain
AMET_RS11275	COG4659	FMN binding
AMET_RS11280	COG4660	Part of a membrane complex involved in electron transport
AMET_RS11285	COG4657	Part of a membrane complex involved in electron transport
AMET_RS11290	COG1245	4Fe-4S binding domain
AMET_RS11290	COG2878	Part of a membrane complex involved in electron transport
AMET_RS11305	COG0424	maF-like protein
AMET_RS11310	COG2003	Belongs to the UPF0758 family
AMET_RS11315	COG1077	Cell shape determining protein MreB Mrl
AMET_RS11330	COG0768	penicillin binding
AMET_RS11335	COG0850	regulation of cytokinetic process
AMET_RS11340	COG2894	cell division
AMET_RS11345	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AMET_RS11350	COG1803	Methylglyoxal synthase
AMET_RS11360	COG1994	Peptidase M50
AMET_RS11380	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AMET_RS11390	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AMET_RS11400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AMET_RS11415	COG1713	HD superfamily hydrolase involved in NAD metabolism
AMET_RS11425	COG0530	calcium, potassium:sodium antiporter activity
AMET_RS11430	COG0799	negative regulation of ribosome biogenesis
AMET_RS11435	COG0495	leucyl-tRNA aminoacylation
AMET_RS11445	COG0251	oxidation-reduction process
AMET_RS11450	COG1760	l-serine dehydratase
AMET_RS11455	COG1760	l-serine dehydratase
AMET_RS11460	COG1686	Belongs to the peptidase S11 family
AMET_RS11470	COG0709	Synthesizes selenophosphate from selenide and ATP
AMET_RS11475	COG1115	amino acid carrier protein
AMET_RS11480	COG1921	L-seryl-tRNASec selenium transferase activity
AMET_RS11490	COG0745	RESPONSE REGULATOR receiver
AMET_RS11495	COG5002	protein histidine kinase activity
AMET_RS11535	COG2155	Conserved Protein
AMET_RS11555	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AMET_RS11560	COG0632	four-way junction helicase activity
AMET_RS11565	COG2255	four-way junction helicase activity
AMET_RS11570	COG2385	sporulation resulting in formation of a cellular spore
AMET_RS11575	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AMET_RS11580	COG0343	queuine tRNA-ribosyltransferase activity
AMET_RS11585	COG1862	Preprotein translocase
AMET_RS11605	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMET_RS11610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMET_RS11620	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AMET_RS11620	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AMET_RS11625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMET_RS11630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMET_RS11635	COG1490	D-aminoacyl-tRNA deacylase activity
AMET_RS11640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMET_RS11650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMET_RS11655	COG0124	histidyl-tRNA synthetase
AMET_RS11660	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AMET_RS11670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AMET_RS11690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMET_RS11695	COG3829	transcription factor binding
AMET_RS11700	COG3804	dihydrodipicolinate reductase
AMET_RS11710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMET_RS11720	COG5012	cobalamin binding
AMET_RS11730	COG3457	Alanine racemase
AMET_RS11775	COG0464	growth
AMET_RS11890	COG3409	Peptidoglycan-binding domain 1 protein
AMET_RS11890	COG3773	Cell wall hydrolase
AMET_RS12015	COG3299	homolog of phage Mu protein gp47
AMET_RS12085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AMET_RS12105	COG2340	Cysteine-rich secretory protein family
AMET_RS12110	COG1091	dTDP-4-dehydrorhamnose reductase activity
AMET_RS12115	COG1959	2 iron, 2 sulfur cluster binding
AMET_RS12125	COG0822	iron-sulfur transferase activity
AMET_RS12135	COG0628	permease
AMET_RS12140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMET_RS12145	COG4472	Bacterial protein of unknown function (DUF965)
AMET_RS12155	COG0667	Aldo Keto reductase
AMET_RS12160	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AMET_RS12165	COG3906	Belongs to the UPF0473 family
AMET_RS12175	COG1489	DNA binding
AMET_RS12180	COG0735	belongs to the Fur family
AMET_RS12185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AMET_RS12200	COG4122	O-methyltransferase activity
AMET_RS12205	COG0826	peptidase U32
AMET_RS12210	COG0572	uridine kinase
AMET_RS12215	COG0768	penicillin binding
AMET_RS12260	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AMET_RS12265	COG4970	Tfp pilus assembly protein FimT
AMET_RS12290	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AMET_RS12295	COG0006	proline dipeptidase activity
AMET_RS12300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMET_RS12310	COG3854	ATPases associated with a variety of cellular activities
AMET_RS12350	COG1302	Protein conserved in bacteria
AMET_RS12355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMET_RS12360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AMET_RS12365	COG1570	exodeoxyribonuclease VII activity
AMET_RS12370	COG1722	exodeoxyribonuclease VII activity
AMET_RS12375	COG0142	geranyltranstransferase activity
AMET_RS12380	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AMET_RS12390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AMET_RS12395	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AMET_RS12400	COG1438	arginine binding
AMET_RS12405	COG0497	DNA recombination
AMET_RS12410	COG0750	zinc metalloprotease
AMET_RS12425	COG2137	regulation of response to DNA damage stimulus
AMET_RS12440	COG0463	Glycosyl transferase, family 2
AMET_RS12455	COG0494	nUDIX hydrolase
AMET_RS12460	COG1300	Membrane
AMET_RS12465	COG4974	Belongs to the 'phage' integrase family
AMET_RS12470	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AMET_RS12475	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AMET_RS12480	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AMET_RS12490	COG1686	Belongs to the peptidase S11 family
AMET_RS12495	COG3620	sequence-specific DNA binding
AMET_RS12495	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AMET_RS12495	COG0617	tRNA 3'-terminal CCA addition
AMET_RS12500	COG1994	Peptidase M50
AMET_RS12505	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AMET_RS12510	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AMET_RS12515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AMET_RS12520	COG4974	Belongs to the 'phage' integrase family
AMET_RS12525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMET_RS12535	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AMET_RS12550	COG1160	GTP binding
AMET_RS12555	COG0464	growth
AMET_RS12560	COG1923	regulation of RNA biosynthetic process
AMET_RS12565	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMET_RS12570	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AMET_RS12575	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AMET_RS12580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMET_RS12640	COG3299	homolog of phage Mu protein gp47
AMET_RS12770	COG0629	single-stranded DNA binding
AMET_RS12870	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMET_RS12890	COG1396	sequence-specific DNA binding
AMET_RS12905	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AMET_RS12910	COG0436	Aminotransferase
AMET_RS12935	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AMET_RS12940	COG0539	negative regulation of cytoplasmic translation
AMET_RS12945	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMET_RS12950	COG0204	Acyl-transferase
AMET_RS12955	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AMET_RS12965	COG2081	HI0933 family
AMET_RS12975	COG1737	Transcriptional regulator
AMET_RS12985	COG1013	pyruvate-flavodoxin oxidoreductase activity
AMET_RS12990	COG0674	pyruvate-flavodoxin oxidoreductase activity
AMET_RS12990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AMET_RS13000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AMET_RS13020	COG1187	pseudouridine synthase activity
AMET_RS13025	COG0445	tRNA wobble uridine modification
AMET_RS13035	COG1686	Belongs to the peptidase S11 family
AMET_RS13045	COG3874	Sporulation protein YtfJ
AMET_RS13060	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AMET_RS13065	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AMET_RS13095	COG0613	PHP domain protein
AMET_RS13100	COG2359	stage V sporulation protein S
AMET_RS13105	COG1418	mRNA catabolic process
AMET_RS13115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMET_RS13120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMET_RS13125	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AMET_RS13130	COG1674	ftsk spoiiie
AMET_RS13135	COG0740	serine-type endopeptidase activity
AMET_RS13145	COG0612	Peptidase, M16
AMET_RS13150	COG0726	polysaccharide deacetylase
AMET_RS13155	COG1185	polyribonucleotide nucleotidyltransferase activity
AMET_RS13160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AMET_RS13165	COG0196	riboflavin kinase activity
AMET_RS13170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AMET_RS13175	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AMET_RS13180	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AMET_RS13185	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AMET_RS13200	COG0195	Participates in both transcription termination and antitermination
AMET_RS13205	COG0779	Required for maturation of 30S ribosomal subunits
AMET_RS13220	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AMET_RS13225	COG0750	zinc metalloprotease
AMET_RS13230	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AMET_RS13235	COG4589	Belongs to the CDS family
AMET_RS13250	COG0233	cytoplasmic translational termination
AMET_RS13255	COG0528	UMP kinase activity
AMET_RS13260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMET_RS13265	COG0052	Belongs to the universal ribosomal protein uS2 family
AMET_RS13290	COG1191	sigma factor activity
AMET_RS13295	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AMET_RS13300	COG1776	CheC inhibitor of MCP methylation
AMET_RS13310	COG0643	Histidine kinase
AMET_RS13310	COG2198	Histidine kinase
AMET_RS13315	COG2201	protein-glutamate methylesterase activity
AMET_RS13325	COG0455	bacterial-type flagellum organization
AMET_RS13330	COG1419	protein localization to endoplasmic reticulum
AMET_RS13335	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AMET_RS13340	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AMET_RS13345	COG1684	flagellar biosynthetic protein fliR
AMET_RS13350	COG1987	bacterial-type flagellum assembly
AMET_RS13355	COG1338	Plays a role in the flagellum-specific transport system
AMET_RS13365	COG2201	protein-glutamate methylesterase activity
AMET_RS13370	COG1776	CheC inhibitor of MCP methylation
AMET_RS13370	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AMET_RS13375	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AMET_RS13430	COG1157	protein secretion by the type III secretion system
AMET_RS13440	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AMET_RS13445	COG1766	The M ring may be actively involved in energy transduction
AMET_RS13450	COG1677	Flagellar hook-basal body complex protein FliE
AMET_RS13455	COG1558	bacterial-type flagellum-dependent cell motility
AMET_RS13460	COG1815	bacterial-type flagellum-dependent cell motility
AMET_RS13470	COG0840	transmembrane signaling receptor activity
AMET_RS13485	COG0784	Response regulator, receiver
AMET_RS13485	COG0835	chemotaxis
AMET_RS13505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMET_RS13510	COG0758	DNA mediated transformation
AMET_RS13520	COG1509	lysine 2,3-aminomutase activity
AMET_RS13525	COG0792	nuclease activity
AMET_RS13530	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AMET_RS13535	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AMET_RS13540	COG0335	large ribosomal subunit rRNA binding
AMET_RS13545	COG0336	Belongs to the RNA methyltransferase TrmD family
AMET_RS13550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AMET_RS13555	COG1837	Belongs to the UPF0109 family
AMET_RS13560	COG0228	four-way junction DNA binding
AMET_RS13565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AMET_RS13575	COG0552	protein localization to endoplasmic reticulum
AMET_RS13580	COG1196	nuclear chromosome segregation
AMET_RS13590	COG0571	ribonuclease III activity
AMET_RS13595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMET_RS13600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMET_RS13605	COG1028	Short-chain dehydrogenase reductase Sdr
AMET_RS13610	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AMET_RS13620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMET_RS13625	COG0416	fatty acid biosynthetic process
AMET_RS13630	COG2030	dehydratase
AMET_RS13635	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AMET_RS13645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AMET_RS13650	COG1323	Belongs to the UPF0348 family
AMET_RS13655	COG3314	Sporulation integral membrane protein YlbJ
AMET_RS13665	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AMET_RS13670	COG0742	ribosomal rna small subunit methyltransferase
AMET_RS13680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AMET_RS13685	COG1461	Dihydroxyacetone kinase
AMET_RS13690	COG1302	Protein conserved in bacteria
AMET_RS13695	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AMET_RS13710	COG1564	THIamine pyrophosphokinase
AMET_RS13715	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AMET_RS13720	COG1162	GTPase activity
AMET_RS13725	COG0515	serine threonine protein kinase
AMET_RS13725	COG2815	serine threonine protein kinase
AMET_RS13730	COG0631	protein serine/threonine phosphatase activity
AMET_RS13735	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AMET_RS13740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AMET_RS13740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMET_RS13745	COG2738	Putative neutral zinc metallopeptidase
AMET_RS13755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AMET_RS13760	COG0242	peptide deformylase activity
AMET_RS13765	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AMET_RS13770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AMET_RS13775	COG1758	RNA polymerase activity
AMET_RS13780	COG0194	GDP metabolic process
AMET_RS13785	COG2052	Domain of unknown function (DUF370)
AMET_RS13790	COG1561	YicC-like family, N-terminal region
AMET_RS13795	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AMET_RS13805	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AMET_RS13810	COG0564	pseudouridine synthase activity
AMET_RS13815	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AMET_RS13820	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AMET_RS13830	COG3599	regulation of cell shape
AMET_RS13835	COG2302	S4 RNA-binding domain
AMET_RS13845	COG1799	cell septum assembly
AMET_RS13850	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AMET_RS13865	COG0517	IMP dehydrogenase activity
AMET_RS13865	COG4175	Glycine betaine
AMET_RS13870	COG4176	ABC-type proline glycine betaine transport system permease component
AMET_RS13885	COG4214	carbohydrate transport
AMET_RS13895	COG4213	ABC transporter substrate-binding protein
AMET_RS13900	COG4213	ABC transporter substrate-binding protein
AMET_RS13905	COG2207	Transcriptional regulator
AMET_RS13905	COG4753	response regulator
AMET_RS13910	COG2972	Histidine kinase
AMET_RS13925	COG0584	glycerophosphoryl diester phosphodiesterase
AMET_RS13930	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AMET_RS13935	COG0542	response to heat
AMET_RS13945	COG1704	LemA family
AMET_RS13950	COG1388	LysM domain
AMET_RS13950	COG0791	NLP P60 protein
AMET_RS14070	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AMET_RS14075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMET_RS14080	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AMET_RS14085	COG1160	GTP binding
AMET_RS14125	COG5002	protein histidine kinase activity
AMET_RS14130	COG0745	RESPONSE REGULATOR receiver
AMET_RS14140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMET_RS14145	COG1873	PFAM PRC-barrel domain
AMET_RS14150	COG1191	sigma factor activity
AMET_RS14155	COG1191	sigma factor activity
AMET_RS14165	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AMET_RS14190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AMET_RS14195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AMET_RS14200	COG0772	Belongs to the SEDS family
AMET_RS14205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMET_RS14210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMET_RS14215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AMET_RS14220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AMET_RS14225	COG0768	penicillin binding
AMET_RS14235	COG0275	rRNA processing
AMET_RS14240	COG2001	Belongs to the MraZ family
AMET_RS14245	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AMET_RS14250	COG0612	Peptidase, M16
AMET_RS14255	COG0612	Peptidase, M16
AMET_RS14275	COG0012	GTP binding
AMET_RS14280	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AMET_RS14285	COG4869	propanediol catabolic process
AMET_RS14305	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AMET_RS14310	COG2096	Adenosyltransferase
AMET_RS14315	COG4608	Belongs to the ABC transporter superfamily
AMET_RS14320	COG0444	Belongs to the ABC transporter superfamily
AMET_RS14325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMET_RS14330	COG0601	transmembrane transport
AMET_RS14335	COG0747	negative chemotaxis
AMET_RS14345	COG4608	Belongs to the ABC transporter superfamily
AMET_RS14350	COG0444	Belongs to the ABC transporter superfamily
AMET_RS14355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMET_RS14360	COG0601	transmembrane transport
AMET_RS14365	COG0747	negative chemotaxis
AMET_RS14380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMET_RS14385	COG1333	cytochrome c biogenesis protein
AMET_RS14425	COG1595	DNA-templated transcription, initiation
AMET_RS14445	COG0789	Transcriptional regulator
AMET_RS14455	COG1051	belongs to the nudix hydrolase family
AMET_RS14460	COG0840	transmembrane signaling receptor activity
AMET_RS14465	COG0793	Belongs to the peptidase S41A family
AMET_RS14490	COG0546	phosphoglycolate phosphatase activity
AMET_RS14495	COG1473	amidohydrolase
AMET_RS14505	COG0840	transmembrane signaling receptor activity
AMET_RS14515	COG0058	SHG alpha-glucan phosphorylase activity
AMET_RS14520	COG0297	glycogen (starch) synthase activity
AMET_RS14525	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AMET_RS14530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AMET_RS14535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMET_RS14550	COG0513	Belongs to the DEAD box helicase family
AMET_RS14555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMET_RS14560	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMET_RS14570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMET_RS14585	COG2084	Dehydrogenase
AMET_RS14595	COG0679	Auxin Efflux Carrier
AMET_RS14600	COG0066	3-isopropylmalate dehydratase activity
AMET_RS14605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMET_RS14615	COG0281	malic enzyme
AMET_RS14625	COG3290	protein histidine kinase activity
AMET_RS14630	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AMET_RS14635	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AMET_RS14655	COG1984	allophanate hydrolase subunit 2
AMET_RS14660	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AMET_RS14665	COG4336	lyase activity
AMET_RS14670	COG1914	H( )-stimulated, divalent metal cation uptake system
AMET_RS14675	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AMET_RS14680	COG2204	response regulator
AMET_RS14685	COG3852	Histidine kinase
AMET_RS14690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMET_RS14720	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AMET_RS14725	COG2384	SAM-dependent methyltransferase
AMET_RS14735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMET_RS14740	COG0358	DNA primase activity
AMET_RS14745	COG1671	Belongs to the UPF0178 family
AMET_RS14750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AMET_RS14760	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AMET_RS14765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMET_RS14770	COG1053	succinate dehydrogenase
AMET_RS14770	COG3976	FMN-binding domain protein
AMET_RS14770	COG0431	NADPH-dependent FMN reductase
AMET_RS14775	COG0745	RESPONSE REGULATOR receiver
AMET_RS14780	COG5002	protein histidine kinase activity
AMET_RS14795	COG0574	Belongs to the PEP-utilizing enzyme family
AMET_RS14795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMET_RS14800	COG1309	transcriptional regulator
AMET_RS14805	COG3976	FMN-binding domain protein
AMET_RS14805	COG1053	succinate dehydrogenase
AMET_RS14805	COG0431	NADPH-dependent FMN reductase
AMET_RS14815	COG0574	Belongs to the PEP-utilizing enzyme family
AMET_RS14815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMET_RS14825	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AMET_RS14830	COG0716	FMN binding
AMET_RS14835	COG1937	Protein conserved in bacteria
AMET_RS14840	COG0534	Mate efflux family protein
AMET_RS14850	COG1695	Transcriptional regulator
AMET_RS14855	COG0574	Belongs to the PEP-utilizing enzyme family
AMET_RS14855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMET_RS14860	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AMET_RS14865	COG0517	IMP dehydrogenase activity
AMET_RS14870	COG0423	glycine-tRNA ligase activity
AMET_RS14875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMET_RS14880	COG1381	Involved in DNA repair and RecF pathway recombination
AMET_RS14885	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AMET_RS14890	COG0295	cytidine deaminase activity
AMET_RS14895	COG1470	cell adhesion involved in biofilm formation
AMET_RS14905	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AMET_RS14910	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AMET_RS14915	COG1480	7TM receptor with intracellular HD hydrolase
AMET_RS14920	COG1702	phosphate starvation-inducible protein PhoH
AMET_RS14940	COG4864	UPF0365 protein
AMET_RS14945	COG1030	water channel activity
AMET_RS14965	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AMET_RS14970	COG0537	adenosine 5'-monophosphoramidase activity
AMET_RS14975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMET_RS14980	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AMET_RS14985	COG2264	protein methyltransferase activity
AMET_RS14990	COG0484	heat shock protein binding
AMET_RS14995	COG0443	Heat shock 70 kDa protein
AMET_RS15000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMET_RS15005	COG1420	regulation of RNA biosynthetic process
AMET_RS15010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMET_RS15015	COG0481	GTPase activity
AMET_RS15030	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AMET_RS15035	COG0268	Binds directly to 16S ribosomal RNA
AMET_RS15045	COG2333	competence protein COMEC
AMET_RS15045	COG0658	competence protein
AMET_RS15055	COG1234	tRNA 3'-trailer cleavage
AMET_RS15065	COG0658	competence protein
AMET_RS15065	COG2333	competence protein COMEC
AMET_RS15100	COG0842	Transport permease protein
AMET_RS15105	COG1131	(ABC) transporter
AMET_RS15110	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AMET_RS15115	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AMET_RS15120	COG0513	Belongs to the DEAD box helicase family
AMET_RS15130	COG0697	spore germination
AMET_RS15145	COG0577	efflux transmembrane transporter activity
AMET_RS15150	COG1136	(ABC) transporter
AMET_RS15160	COG1285	pathogenesis
AMET_RS15185	COG5002	protein histidine kinase activity
AMET_RS15190	COG0745	RESPONSE REGULATOR receiver
AMET_RS15200	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AMET_RS15205	COG2086	electron transfer activity
AMET_RS15210	COG1960	acyl-CoA dehydrogenase activity
AMET_RS15215	COG2030	dehydratase
AMET_RS15260	COG0330	HflC and HflK could
AMET_RS15280	COG0187	DNA topoisomerase II activity
AMET_RS15310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AMET_RS15315	COG0584	glycerophosphoryl diester phosphodiesterase
AMET_RS15325	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AMET_RS15355	COG0747	negative chemotaxis
AMET_RS15365	COG0237	dephospho-CoA kinase activity
AMET_RS15370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMET_RS15370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMET_RS15385	COG1988	membrane-bound metal-dependent
AMET_RS15435	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AMET_RS15440	COG0583	DNA-binding transcription factor activity
AMET_RS15450	COG1362	aminopeptidase activity
AMET_RS15455	COG2197	response regulator
AMET_RS15485	COG1228	amidohydrolase
AMET_RS15490	COG2986	histidine ammonia-lyase
AMET_RS15500	COG1846	Transcriptional regulator
AMET_RS15505	COG0739	heme binding
AMET_RS15515	COG1597	lipid kinase activity
AMET_RS15520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMET_RS15540	COG1132	(ABC) transporter
AMET_RS15545	COG1132	(ABC) transporter
AMET_RS15550	COG2235	arginine
AMET_RS15555	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AMET_RS15565	COG1716	ATPase activity
AMET_RS15565	COG5001	Diguanylate cyclase
AMET_RS15575	COG1796	DNA polymerase
AMET_RS15575	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AMET_RS15585	COG0303	'Molybdopterin
AMET_RS15590	COG0303	'Molybdopterin
AMET_RS15595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMET_RS15615	COG0564	pseudouridine synthase activity
AMET_RS15620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMET_RS15625	COG1301	dicarboxylic acid transport
AMET_RS15630	COG2201	protein-glutamate methylesterase activity
AMET_RS15635	COG4191	Histidine kinase
AMET_RS15665	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AMET_RS15695	COG4659	FMN binding
AMET_RS15725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMET_RS15735	COG2171	N-acyltransferase activity
AMET_RS15740	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AMET_RS15745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMET_RS15750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AMET_RS15760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMET_RS15770	COG0697	spore germination
AMET_RS15785	COG0095	Lipoate-protein ligase
AMET_RS15805	COG5002	protein histidine kinase activity
AMET_RS15810	COG0745	RESPONSE REGULATOR receiver
AMET_RS15820	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
AMET_RS15825	COG0697	spore germination
AMET_RS15830	COG2851	Citrate transporter
AMET_RS15835	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AMET_RS15840	COG0583	DNA-binding transcription factor activity
AMET_RS15845	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AMET_RS15850	COG0511	ligase activity, forming carbon-carbon bonds
AMET_RS15860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMET_RS15890	COG3052	prosthetic group binding
AMET_RS15910	COG0281	malic enzyme
AMET_RS15920	COG3850	Histidine kinase
AMET_RS15960	COG1268	BioY protein
AMET_RS15965	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AMET_RS15970	COG0840	transmembrane signaling receptor activity
AMET_RS15980	COG2239	Acts as a magnesium transporter
AMET_RS16015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AMET_RS16020	COG2204	response regulator
AMET_RS16025	COG3852	Histidine kinase
AMET_RS16035	COG2205	protein histidine kinase activity
AMET_RS16085	COG1388	LysM domain
AMET_RS16085	COG3858	chitin binding
AMET_RS16090	COG2217	Heavy metal translocating P-type atpase
AMET_RS16095	COG2217	Heavy metal translocating P-type atpase
AMET_RS16120	COG2226	methyltransferase
AMET_RS16125	COG1032	radical SAM domain protein
AMET_RS16130	COG3546	catalase activity
AMET_RS16145	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AMET_RS16180	COG4134	Bacterial extracellular solute-binding protein
AMET_RS16190	COG0398	Pfam SNARE associated Golgi protein
AMET_RS16205	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AMET_RS16225	COG0732	type I restriction modification DNA specificity domain
AMET_RS16235	COG0569	domain protein
AMET_RS16245	COG0745	RESPONSE REGULATOR receiver
AMET_RS16250	COG2205	protein histidine kinase activity
AMET_RS16260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AMET_RS16280	COG2056	Na+-H+ antiporter family
AMET_RS16285	COG1983	PspC domain protein
AMET_RS16295	COG5578	integral membrane protein
AMET_RS16300	COG3507	Belongs to the glycosyl hydrolase 43 family
AMET_RS16305	COG0395	ABC-type sugar transport system, permease component
AMET_RS16325	COG2972	Histidine kinase
AMET_RS16330	COG3842	ATPase activity
AMET_RS16340	COG1876	peptidase activity
AMET_RS16345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMET_RS16355	COG0444	Belongs to the ABC transporter superfamily
AMET_RS16360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMET_RS16365	COG0601	transmembrane transport
AMET_RS16380	COG2878	Part of a membrane complex involved in electron transport
AMET_RS16385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMET_RS16390	COG0037	tRNA processing
AMET_RS16395	COG0488	(ABC) transporter
AMET_RS16405	COG0006	proline dipeptidase activity
AMET_RS16425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMET_RS16480	COG1598	PFAM Uncharacterised protein family UPF0150
AMET_RS16505	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AMET_RS16520	COG0517	IMP dehydrogenase activity
AMET_RS16535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMET_RS16560	COG0488	(ABC) transporter
AMET_RS16565	COG0488	(ABC) transporter
AMET_RS16570	COG0646	methionine synthase
AMET_RS16570	COG1410	methionine synthase
AMET_RS16580	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AMET_RS16585	COG2873	o-acetylhomoserine
AMET_RS16590	COG2340	Cysteine-rich secretory protein family
AMET_RS16595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AMET_RS16600	COG0505	Belongs to the CarA family
AMET_RS16605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMET_RS16610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AMET_RS16615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AMET_RS16620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AMET_RS16640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMET_RS16645	COG0154	amidase activity
AMET_RS16650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMET_RS16655	COG0017	Asparaginyl-tRNA synthetase
AMET_RS16660	COG0347	Belongs to the P(II) protein family
AMET_RS16665	COG0004	ammonium transporteR
AMET_RS16670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMET_RS16690	COG0067	glutamate synthase
AMET_RS16690	COG0069	glutamate synthase activity
AMET_RS16690	COG0070	glutamate synthase
AMET_RS16695	COG3830	Belongs to the UPF0237 family
AMET_RS16700	COG2848	UPF0210 protein
AMET_RS16705	COG0028	Belongs to the TPP enzyme family
AMET_RS16710	COG0129	dihydroxy-acid dehydratase activity
AMET_RS16715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AMET_RS16720	COG0440	acetolactate synthase activity
AMET_RS16725	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMET_RS16735	COG0463	Glycosyl transferase, family 2
AMET_RS16735	COG0457	Tetratricopeptide repeat
AMET_RS16740	COG0527	aspartate kinase activity
AMET_RS16750	COG3051	citrate lyase alpha subunit
AMET_RS16760	COG3052	prosthetic group binding
AMET_RS16765	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AMET_RS16765	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AMET_RS16795	COG0028	Belongs to the TPP enzyme family
AMET_RS16800	COG0440	acetolactate synthase activity
AMET_RS16805	COG4868	Belongs to the UPF0371 family
AMET_RS16835	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AMET_RS16840	COG1686	Belongs to the peptidase S11 family
AMET_RS16910	COG0438	transferase activity, transferring glycosyl groups
AMET_RS16915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMET_RS16920	COG4641	Protein conserved in bacteria
AMET_RS16920	COG1388	LysM domain
AMET_RS16935	COG0189	ligase activity
AMET_RS16955	COG0463	Glycosyl transferase, family 2
AMET_RS16965	COG0438	transferase activity, transferring glycosyl groups
AMET_RS16975	COG1307	EDD domain protein, DegV family
AMET_RS16980	COG0473	3-isopropylmalate dehydrogenase activity
AMET_RS16985	COG0066	3-isopropylmalate dehydratase activity
AMET_RS16990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMET_RS16995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMET_RS17005	COG0431	NADPH-dependent FMN reductase
AMET_RS17005	COG1053	succinate dehydrogenase
AMET_RS17005	COG3976	FMN-binding domain protein
AMET_RS17010	COG1757	Na H antiporter
AMET_RS17015	COG1666	GTP binding
AMET_RS17025	COG4807	Protein conserved in bacteria
AMET_RS17035	COG0783	Belongs to the Dps family
AMET_RS17040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AMET_RS17045	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AMET_RS17050	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AMET_RS17055	COG0363	glucosamine-6-phosphate deaminase activity
AMET_RS17060	COG1361	Conserved repeat domain
AMET_RS17100	COG2165	general secretion pathway protein
AMET_RS17105	COG1459	type II secretion system
AMET_RS17115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMET_RS17125	COG1032	radical SAM domain protein
AMET_RS17130	COG1032	radical SAM domain protein
AMET_RS17160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AMET_RS17185	COG0529	Catalyzes the synthesis of activated sulfate
AMET_RS17190	COG0471	metal ion transport
AMET_RS17200	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMET_RS17210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AMET_RS17220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AMET_RS17275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMET_RS17285	COG1433	Dinitrogenase iron-molybdenum cofactor
AMET_RS17285	COG0535	radical SAM domain protein
AMET_RS17310	COG0347	Belongs to the P(II) protein family
AMET_RS17320	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AMET_RS17345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMET_RS17345	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMET_RS17350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMET_RS17350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMET_RS17355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMET_RS17360	COG0129	dihydroxy-acid dehydratase activity
AMET_RS17365	COG2207	Transcriptional regulator
AMET_RS17365	COG4753	response regulator
AMET_RS17375	COG3459	Glycosyltransferase 36 associated
AMET_RS17380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMET_RS17405	COG0803	Belongs to the bacterial solute-binding protein 9 family
AMET_RS17415	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AMET_RS17435	COG0577	efflux transmembrane transporter activity
AMET_RS17440	COG1136	(ABC) transporter
AMET_RS17445	COG0577	efflux transmembrane transporter activity
AMET_RS17450	COG1136	(ABC) transporter
AMET_RS17455	COG2205	protein histidine kinase activity
AMET_RS17460	COG0745	RESPONSE REGULATOR receiver
AMET_RS17490	COG3279	Response regulator of the LytR AlgR family
AMET_RS17520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AMET_RS17530	COG0557	exoribonuclease II activity
AMET_RS17550	COG0148	phosphopyruvate hydratase activity
AMET_RS17560	COG0149	triose-phosphate isomerase activity
AMET_RS17565	COG0126	phosphoglycerate kinase activity
AMET_RS17575	COG2390	Transcriptional regulator
AMET_RS17580	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AMET_RS17585	COG1079	Belongs to the binding-protein-dependent transport system permease family
AMET_RS17590	COG4603	Belongs to the binding-protein-dependent transport system permease family
AMET_RS17595	COG3845	ABC transporter
AMET_RS17600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AMET_RS17605	COG1328	CTP reductase activity
AMET_RS17610	COG1744	ABC transporter substrate-binding protein PnrA-like
AMET_RS17625	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AMET_RS17650	COG3118	belongs to the thioredoxin family
AMET_RS17670	COG1307	EDD domain protein, DegV family
AMET_RS17675	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AMET_RS17690	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AMET_RS17695	COG0673	inositol 2-dehydrogenase activity
AMET_RS17705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMET_RS17710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AMET_RS17715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AMET_RS17730	COG0737	Belongs to the 5'-nucleotidase family
AMET_RS17735	COG0737	Belongs to the 5'-nucleotidase family
AMET_RS17750	COG0735	belongs to the Fur family
AMET_RS17755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMET_RS17760	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMET_RS17765	COG1492	cobalamin metabolic process
AMET_RS17770	COG1120	ATPase activity
AMET_RS17775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMET_RS17780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AMET_RS17790	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AMET_RS17820	COG2720	vancomycin resistance protein
AMET_RS17830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AMET_RS17855	COG0681	Belongs to the peptidase S26 family
AMET_RS17860	COG0156	8-amino-7-oxononanoate synthase activity
AMET_RS17865	COG1067	ATP-dependent peptidase activity
AMET_RS17875	COG0681	Belongs to the peptidase S26 family
AMET_RS17900	COG2066	Belongs to the glutaminase family
AMET_RS17910	COG0517	IMP dehydrogenase activity
AMET_RS17915	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AMET_RS17920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AMET_RS17925	COG0681	Belongs to the peptidase S26 family
AMET_RS17940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMET_RS17945	COG2339	peptidase activity
AMET_RS17950	COG2249	NAD(P)H dehydrogenase (quinone) activity
AMET_RS17955	COG3546	catalase activity
AMET_RS17970	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AMET_RS17975	COG0456	acetyltransferase
AMET_RS17980	COG0482	sulfurtransferase activity
AMET_RS17985	COG1126	abc transporter atp-binding protein
AMET_RS17990	COG0765	amino acid transport
AMET_RS17995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMET_RS18000	COG0791	NLP P60 protein
AMET_RS18015	COG4187	Peptidase family M20/M25/M40
AMET_RS18030	COG1649	PFAM Uncharacterised BCR, COG1649
AMET_RS18040	COG1187	pseudouridine synthase activity
AMET_RS18050	COG1183	phosphatidylcholine synthase activity
AMET_RS18055	COG0191	fructose-bisphosphate aldolase activity
AMET_RS18070	COG2357	RelA SpoT domain protein
AMET_RS18085	COG1242	4 iron, 4 sulfur cluster binding
AMET_RS18100	COG1361	Conserved repeat domain
AMET_RS18105	COG1705	Flagellar rod assembly protein muramidase FlgJ
AMET_RS18105	COG1388	LysM domain
AMET_RS18110	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AMET_RS18120	COG2155	Conserved Protein
AMET_RS18130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMET_RS18145	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AMET_RS18155	COG0697	spore germination
AMET_RS18170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMET_RS18195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMET_RS18205	COG1757	Na H antiporter
AMET_RS18215	COG0626	cystathionine gamma-synthase activity
AMET_RS18220	COG0626	cystathionine gamma-synthase activity
AMET_RS18225	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AMET_RS18230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AMET_RS18235	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMET_RS18240	COG5002	protein histidine kinase activity
AMET_RS18260	COG2197	response regulator
AMET_RS18265	COG4585	Histidine kinase
AMET_RS18280	COG1131	(ABC) transporter
AMET_RS18300	COG0426	domain, Protein
AMET_RS18310	COG0038	chloride channel
AMET_RS18315	COG2323	membrane
AMET_RS18320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMET_RS18325	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMET_RS18330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMET_RS18340	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AMET_RS18365	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AMET_RS18370	COG1473	amidohydrolase
AMET_RS18380	COG4895	conserved protein (DUF2196)
AMET_RS18385	COG0697	spore germination
AMET_RS18395	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AMET_RS18405	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMET_RS18410	COG0405	Gamma-glutamyltransferase
AMET_RS18415	COG3875	lactate racemase activity
AMET_RS18420	COG0277	FAD linked oxidase domain protein
AMET_RS18425	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AMET_RS18430	COG2086	electron transfer activity
AMET_RS18435	COG2186	Transcriptional regulator
AMET_RS18440	COG1620	l-lactate permease
AMET_RS18455	COG0840	transmembrane signaling receptor activity
AMET_RS18470	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AMET_RS18485	COG0835	chemotaxis
AMET_RS18495	COG1131	(ABC) transporter
AMET_RS18505	COG1151	hydroxylamine reductase activity
AMET_RS18510	COG0437	4 iron, 4 sulfur cluster binding
AMET_RS18515	COG3829	transcription factor binding
AMET_RS18515	COG3290	protein histidine kinase activity
AMET_RS18520	COG1164	Oligoendopeptidase f
AMET_RS18530	COG1199	ATP-dependent helicase activity
AMET_RS18540	COG1120	ATPase activity
AMET_RS18545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMET_RS18550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMET_RS18555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AMET_RS18565	COG0275	rRNA processing
AMET_RS18570	COG0840	transmembrane signaling receptor activity
AMET_RS18585	COG0653	protein targeting
AMET_RS18605	COG0246	Mannitol dehydrogenase
AMET_RS18610	COG1312	Catalyzes the dehydration of D-mannonate
AMET_RS18630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMET_RS18635	COG1802	Transcriptional regulator
AMET_RS18640	COG4279	zinc finger
AMET_RS18645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AMET_RS18660	COG1070	Carbohydrate kinase
AMET_RS18665	COG1940	carbohydrate kinase activity
AMET_RS18670	COG2115	Belongs to the xylose isomerase family
AMET_RS18675	COG4214	carbohydrate transport
AMET_RS18685	COG4213	ABC transporter substrate-binding protein
AMET_RS18690	COG2017	converts alpha-aldose to the beta-anomer
AMET_RS18705	COG3279	Response regulator of the LytR AlgR family
AMET_RS18710	COG2972	Histidine kinase
AMET_RS18715	COG0534	Mate efflux family protein
AMET_RS18720	COG1132	(ABC) transporter
AMET_RS18725	COG1132	(ABC) transporter
AMET_RS18725	COG2375	cellular response to nickel ion
AMET_RS18745	COG1595	DNA-templated transcription, initiation
AMET_RS18775	COG2378	regulation of single-species biofilm formation
AMET_RS18800	COG4869	propanediol catabolic process
AMET_RS18805	COG1012	belongs to the aldehyde dehydrogenase family
AMET_RS18805	COG1454	alcohol dehydrogenase
AMET_RS18810	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AMET_RS18825	COG4656	Part of a membrane complex involved in electron transport
AMET_RS18830	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
AMET_RS18860	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AMET_RS18865	COG1882	Formate acetyltransferase
AMET_RS18900	COG2972	Histidine kinase
AMET_RS18910	COG2207	Transcriptional regulator
AMET_RS18915	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMET_RS18955	COG2119	membrane
AMET_RS18970	COG3976	FMN-binding domain protein
AMET_RS18970	COG1053	succinate dehydrogenase
AMET_RS18990	COG1053	succinate dehydrogenase
AMET_RS19005	COG1132	(ABC) transporter
AMET_RS19015	COG1131	(ABC) transporter
AMET_RS19045	COG0534	Mate efflux family protein
AMET_RS19050	COG1129	ABC transporter
AMET_RS19065	COG0840	transmembrane signaling receptor activity
AMET_RS19105	COG3875	lactate racemase activity
AMET_RS19110	COG1464	Belongs to the NlpA lipoprotein family
AMET_RS19115	COG2011	ABC-type metal ion transport system permease component
AMET_RS19120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMET_RS19185	COG1131	(ABC) transporter
AMET_RS19315	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AMET_RS19320	COG0789	Transcriptional regulator
AMET_RS19355	COG1131	(ABC) transporter
AMET_RS19410	COG0577	efflux transmembrane transporter activity
AMET_RS19415	COG1136	(ABC) transporter
AMET_RS19420	COG0642	Histidine kinase
AMET_RS19425	COG0745	RESPONSE REGULATOR receiver
AMET_RS19485	COG3843	relaxase mobilization nuclease domain protein
AMET_RS19505	COG0551	DNA topoisomerase type I activity
AMET_RS19505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMET_RS19510	COG0551	DNA topoisomerase type I activity
AMET_RS19510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMET_RS19520	COG1196	nuclear chromosome segregation
AMET_RS19610	COG1475	DNA binding
AMET_RS19615	COG1192	Involved in chromosome partitioning
AMET_RS19620	COG0798	PFAM Bile acid sodium symporter
AMET_RS19675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMET_RS19675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMET_RS19775	COG4695	Portal protein
AMET_RS19790	COG4626	Terminase
AMET_RS19790	COG1802	Transcriptional regulator
AMET_RS19905	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AMET_RS19945	COG0824	Thioesterase
AMET_RS19970	COG0205	6-phosphofructokinase activity
AMET_RS19995	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AMET_RS20000	COG1428	Deoxynucleoside kinase
AMET_RS20005	COG1428	Deoxynucleoside kinase
AMET_RS20055	COG3290	protein histidine kinase activity
AMET_RS20065	COG1481	regulation of sporulation
AMET_RS20075	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AMET_RS20080	COG1660	Displays ATPase and GTPase activities
AMET_RS20085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AMET_RS20100	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AMET_RS20110	COG3383	formate dehydrogenase (NAD+) activity
AMET_RS20140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AMET_RS20145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AMET_RS20150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AMET_RS20185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMET_RS20195	COG2376	Dihydroxyacetone kinase
AMET_RS20215	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMET_RS20230	COG1940	carbohydrate kinase activity
AMET_RS20235	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AMET_RS20240	COG1983	PspC domain protein
AMET_RS20245	COG0322	excinuclease ABC activity
AMET_RS20255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMET_RS20260	COG0556	nucleotide-excision repair
AMET_RS20265	COG0793	Belongs to the peptidase S41A family
AMET_RS20270	COG0739	heme binding
AMET_RS20275	COG2177	Part of the ABC transporter FtsEX involved in
AMET_RS20280	COG2884	Cell division ATP-binding protein ftsE
AMET_RS20285	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AMET_RS20290	COG1067	ATP-dependent peptidase activity
AMET_RS20295	COG1388	LysM domain
AMET_RS20295	COG3942	CHAP domain
AMET_RS20310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AMET_RS20315	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AMET_RS20335	COG2337	Toxic component of a toxin-antitoxin (TA) module
AMET_RS20355	COG0736	holo-[acyl-carrier-protein] synthase activity
AMET_RS20370	COG0651	ATP synthesis coupled electron transport
AMET_RS20375	COG0651	ATP synthesis coupled electron transport
AMET_RS20380	COG0651	ATP synthesis coupled electron transport
AMET_RS20390	COG2111	Na H antiporter
AMET_RS20405	COG1320	monovalent cation:proton antiporter activity
AMET_RS20410	COG2212	antiporter activity
AMET_RS20415	COG1863	multisubunit Na H antiporter MnhE subunit
AMET_RS20435	COG4555	ABC transporter
AMET_RS20445	COG0517	IMP dehydrogenase activity
AMET_RS20450	COG0419	ATPase involved in DNA repair
AMET_RS20455	COG0420	3'-5' exonuclease activity
AMET_RS20460	COG1074	ATP-dependent DNA helicase activity
AMET_RS20475	COG0577	efflux transmembrane transporter activity
AMET_RS20475	COG1136	(ABC) transporter
AMET_RS20490	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AMET_RS20510	COG1592	Rubrerythrin
AMET_RS20520	COG0363	glucosamine-6-phosphate deaminase activity
AMET_RS20525	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AMET_RS20530	COG3394	polysaccharide catabolic process
AMET_RS20535	COG1486	melibiose metabolic process
AMET_RS20540	COG1447	Phosphotransferase system cellobiose-specific component IIA
AMET_RS20545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AMET_RS20550	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AMET_RS20555	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AMET_RS20560	COG1737	Transcriptional regulator
AMET_RS20565	COG2971	BadF BadG BcrA BcrD
AMET_RS20580	COG1447	Phosphotransferase system cellobiose-specific component IIA
AMET_RS20585	COG1486	melibiose metabolic process
AMET_RS20590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AMET_RS20600	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AMET_RS20600	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AMET_RS20605	COG0688	phosphatidylethanolamine metabolic process
AMET_RS20615	COG0540	Belongs to the ATCase OTCase family
AMET_RS20625	COG2197	response regulator
AMET_RS20630	COG4585	Histidine kinase
AMET_RS20645	COG1131	(ABC) transporter
AMET_RS20650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AMET_RS20655	COG0167	dihydroorotate dehydrogenase activity
AMET_RS20660	COG0543	2 iron, 2 sulfur cluster binding
AMET_RS20675	COG0284	orotidine-5'-phosphate decarboxylase activity
AMET_RS20680	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMET_RS20690	COG2362	D-Aminopeptidase
AMET_RS20695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMET_RS20700	COG0017	Asparaginyl-tRNA synthetase
AMET_RS20710	COG0789	Transcriptional regulator
AMET_RS20735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMET_RS20755	COG0813	purine-nucleoside phosphorylase activity
AMET_RS20760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMET_RS20765	COG0534	Mate efflux family protein
AMET_RS20775	COG0352	thiamine-phosphate diphosphorylase activity
AMET_RS20780	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AMET_RS20790	COG2022	thiamine diphosphate biosynthetic process
AMET_RS20835	COG2851	Citrate transporter
AMET_RS20840	COG3829	transcription factor binding
AMET_RS20840	COG3290	protein histidine kinase activity
AMET_RS20850	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AMET_RS20855	COG3829	transcription factor binding
AMET_RS20855	COG3290	protein histidine kinase activity
AMET_RS20865	COG1595	DNA-templated transcription, initiation
AMET_RS20875	COG0726	polysaccharide deacetylase
AMET_RS20880	COG2309	aminopeptidase activity
AMET_RS20885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMET_RS20890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AMET_RS20895	COG0534	Mate efflux family protein
AMET_RS20905	COG1794	racemase activity, acting on amino acids and derivatives
AMET_RS20915	COG1272	protein, Hemolysin III
AMET_RS20925	COG1295	ribonuclease BN
AMET_RS20945	COG2154	pterin-4-alpha-carbinolamine dehydratase
AMET_RS20950	COG1063	alcohol dehydrogenase
AMET_RS20965	COG3711	transcriptional antiterminator
AMET_RS20985	COG0473	3-isopropylmalate dehydrogenase activity
AMET_RS20990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMET_RS21015	COG0456	acetyltransferase
AMET_RS21050	COG1418	mRNA catabolic process
AMET_RS21065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AMET_RS21105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMET_RS21110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMET_RS21115	COG1966	Carbon starvation protein
AMET_RS21150	COG3426	butyrate kinase activity
AMET_RS21155	COG0280	phosphate acetyltransferase
AMET_RS21160	COG3426	butyrate kinase activity
AMET_RS21170	COG3290	protein histidine kinase activity
AMET_RS21170	COG3829	transcription factor binding
AMET_RS21180	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AMET_RS21190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMET_RS21190	COG5322	oxidoreductase activity
AMET_RS21610	COG1971	Probably functions as a manganese efflux pump
AMET_RS21650	COG2119	membrane
AMET_RS21655	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AMET_RS21675	COG2323	membrane
AMET_RS21680	COG1902	pentaerythritol trinitrate reductase activity
AMET_RS21685	COG1473	amidohydrolase
AMET_RS21690	COG0019	diaminopimelate decarboxylase activity
AMET_RS21700	COG1968	undecaprenyl-diphosphatase activity
AMET_RS21865	COG3409	Peptidoglycan-binding domain 1 protein
AMET_RS21865	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMET_RS21910	COG1191	sigma factor activity
AMET_RS21950	COG2842	Transposition protein
AMET_RS21990	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AMET_RS21995	COG1694	Mazg nucleotide pyrophosphohydrolase
AMET_RS22005	COG0367	asparagine synthase
AMET_RS22010	COG1253	flavin adenine dinucleotide binding
AMET_RS22020	COG1376	ErfK ybiS ycfS ynhG family protein
AMET_RS22060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AMET_RS22065	COG0569	domain protein
AMET_RS22085	COG3706	GGDEF domain
AMET_RS22085	COG4251	negative regulation of phosphorylation
AMET_RS22085	COG2203	Gaf domain
AMET_RS22085	COG5001	Diguanylate cyclase
AMET_RS22100	COG0789	Transcriptional regulator
AMET_RS22100	COG4978	Transcriptional regulator
AMET_RS22105	COG0010	Belongs to the arginase family
AMET_RS22110	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AMET_RS22115	COG0321	lipoyl(octanoyl) transferase activity
AMET_RS22145	COG0583	DNA-binding transcription factor activity
AMET_RS22160	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AMET_RS22170	COG1592	Rubrerythrin
AMET_RS22175	COG2861	carbohydrate metabolic process
AMET_RS22185	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMET_RS22195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AMET_RS22200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AMET_RS22210	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AMET_RS22220	COG1122	ATPase activity
AMET_RS22225	COG0203	ribosomal protein L17
AMET_RS22230	COG0202	RNA polymerase activity
AMET_RS22235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AMET_RS22240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AMET_RS22245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AMET_RS22250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AMET_RS22255	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AMET_RS22265	COG0024	Methionine aminopeptidase
AMET_RS22270	COG0563	adenylate kinase activity
AMET_RS22275	COG0201	protein transport
AMET_RS22280	COG0200	Binds to the 23S rRNA
AMET_RS22285	COG1841	ribosomal large subunit assembly
AMET_RS22290	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AMET_RS22295	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AMET_RS22300	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AMET_RS22305	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AMET_RS22310	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AMET_RS22315	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AMET_RS22320	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AMET_RS22325	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AMET_RS22330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AMET_RS22335	COG0255	Belongs to the universal ribosomal protein uL29 family
AMET_RS22340	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AMET_RS22345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AMET_RS22350	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AMET_RS22355	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AMET_RS22360	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AMET_RS22365	COG0089	rRNA binding
AMET_RS22370	COG0088	Forms part of the polypeptide exit tunnel
AMET_RS22375	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AMET_RS22380	COG0051	transcription antitermination factor activity, RNA binding
AMET_RS22385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMET_RS22390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMET_RS22395	COG0049	tRNA binding
AMET_RS22400	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AMET_RS22405	COG1358	cellular component organization or biogenesis
AMET_RS22410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AMET_RS22415	COG0085	RNA polymerase activity
AMET_RS22420	COG0222	ribosome binding
AMET_RS22425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AMET_RS22430	COG0081	regulation of translation
AMET_RS22435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMET_RS22440	COG0250	Participates in transcription elongation, termination and antitermination
AMET_RS22450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMET_RS22460	COG3688	RNA-binding protein containing a PIN domain
AMET_RS22465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMET_RS22485	COG0215	cysteine-tRNA ligase activity
AMET_RS22490	COG1045	serine acetyltransferase
AMET_RS22495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMET_RS22495	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AMET_RS22500	COG4086	secreted protein
AMET_RS22505	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AMET_RS22510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMET_RS22515	COG4956	integral membrane protein (PIN domain superfamily)
AMET_RS22520	COG1329	Transcriptional regulator
AMET_RS22530	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AMET_RS22535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AMET_RS22540	COG0542	response to heat
AMET_RS22545	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AMET_RS22550	COG3880	PFAM UvrB UvrC protein
AMET_RS22555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMET_RS22560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMET_RS22565	COG2032	superoxide dismutase activity
AMET_RS22575	COG0038	chloride channel
AMET_RS22595	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMET_RS22615	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AMET_RS22620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMET_RS22630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AMET_RS22635	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AMET_RS22645	COG0840	transmembrane signaling receptor activity
AMET_RS22650	COG2610	gluconate transmembrane transporter activity
AMET_RS22660	COG3829	transcription factor binding
AMET_RS22660	COG3290	protein histidine kinase activity
AMET_RS22665	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AMET_RS22665	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AMET_RS22670	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AMET_RS22675	COG0511	ligase activity, forming carbon-carbon bonds
AMET_RS22685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMET_RS22690	COG0346	lactoylglutathione lyase activity
AMET_RS22700	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMET_RS22700	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMET_RS22705	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMET_RS22705	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMET_RS22710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMET_RS22715	COG0037	tRNA processing
AMET_RS22725	COG2304	oxidoreductase activity
AMET_RS22730	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMET_RS22735	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AMET_RS22740	COG1193	negative regulation of DNA recombination
AMET_RS22755	COG0604	alcohol dehydrogenase
AMET_RS22760	COG3829	transcription factor binding
AMET_RS22765	COG0116	Belongs to the methyltransferase superfamily
AMET_RS22775	COG1408	metallophosphoesterase
AMET_RS22785	COG1151	hydroxylamine reductase activity
AMET_RS22800	COG0436	Aminotransferase
AMET_RS22805	COG3608	succinylglutamate desuccinylase aspartoacylase
AMET_RS22805	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AMET_RS22810	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AMET_RS22810	COG3608	succinylglutamate desuccinylase aspartoacylase
AMET_RS22815	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AMET_RS22825	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AMET_RS22850	COG0402	S-adenosylhomocysteine deaminase activity
AMET_RS22855	COG2252	PERMEase
AMET_RS22860	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AMET_RS22880	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AMET_RS22895	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AMET_RS22900	COG0163	prenyltransferase activity
AMET_RS22915	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AMET_RS22925	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AMET_RS22930	COG3835	regulator
AMET_RS22935	COG3404	Formiminotransferase-cyclodeaminase
AMET_RS22975	COG0814	amino acid
AMET_RS22980	COG0814	amino acid
AMET_RS22990	COG0697	spore germination
AMET_RS23000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMET_RS23010	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AMET_RS23030	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AMET_RS23035	COG2235	arginine
AMET_RS23040	COG4466	Protein conserved in bacteria
AMET_RS23045	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMET_RS23065	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMET_RS23070	COG1757	Na H antiporter
AMET_RS23080	COG3976	FMN-binding domain protein
AMET_RS23080	COG1053	succinate dehydrogenase
AMET_RS23080	COG0431	NADPH-dependent FMN reductase
AMET_RS23085	COG0704	Plays a role in the regulation of phosphate uptake
AMET_RS23090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMET_RS23095	COG0581	inorganic phosphate transmembrane transporter activity
AMET_RS23100	COG0573	inorganic phosphate transmembrane transporter activity
AMET_RS23105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AMET_RS23110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMET_RS23120	COG3842	ATPase activity
AMET_RS23135	COG0183	Belongs to the thiolase family
AMET_RS23140	COG1028	Short-chain dehydrogenase reductase Sdr
AMET_RS23145	COG0628	permease
AMET_RS23150	COG2323	membrane
AMET_RS23175	COG0840	transmembrane signaling receptor activity
AMET_RS23200	COG2414	aldehyde ferredoxin oxidoreductase
AMET_RS23215	COG3383	formate dehydrogenase (NAD+) activity
AMET_RS23225	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AMET_RS23235	COG0653	protein targeting
AMET_RS23240	COG0534	Mate efflux family protein
AMET_RS23250	COG2033	superoxide reductase activity
AMET_RS23260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMET_RS23270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMET_RS23270	COG1013	pyruvate-flavodoxin oxidoreductase activity
AMET_RS23270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AMET_RS23270	COG0674	pyruvate-flavodoxin oxidoreductase activity
AMET_RS23275	COG1132	(ABC) transporter
AMET_RS23300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMET_RS23300	COG0723	plastoquinol--plastocyanin reductase activity
AMET_RS23310	COG3681	Belongs to the UPF0597 family
AMET_RS23315	COG3829	transcription factor binding
AMET_RS23320	COG2070	2-Nitropropane dioxygenase
AMET_RS23340	COG1309	transcriptional regulator
AMET_RS23355	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMET_RS23360	COG1917	Cupin 2, conserved barrel domain protein
AMET_RS23360	COG4977	sequence-specific DNA binding
AMET_RS23400	COG1595	DNA-templated transcription, initiation
AMET_RS23455	COG1595	DNA-templated transcription, initiation
AMET_RS23465	COG0514	ATP-dependent DNA helicase (RecQ)
AMET_RS23470	COG0346	lactoylglutathione lyase activity
AMET_RS23480	COG1187	pseudouridine synthase activity
AMET_RS23485	COG0513	Belongs to the DEAD box helicase family
AMET_RS23500	COG2358	TRAP transporter, solute receptor (TAXI family
AMET_RS23530	COG2391	methyltransferase activity
AMET_RS23540	COG2391	methyltransferase activity
AMET_RS23550	COG0697	spore germination
AMET_RS23555	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AMET_RS23570	COG1124	(ABC) transporter
AMET_RS23580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMET_RS23590	COG0747	negative chemotaxis
AMET_RS23595	COG2814	Major facilitator Superfamily
AMET_RS23605	COG2514	catechol 2,3-dioxygenase activity
AMET_RS23610	COG0456	acetyltransferase
AMET_RS23620	COG0697	spore germination
AMET_RS23625	COG0745	RESPONSE REGULATOR receiver
AMET_RS23670	COG3842	ATPase activity
AMET_RS23690	COG0395	ABC-type sugar transport system, permease component
AMET_RS23695	COG1175	transmembrane transport
AMET_RS23700	COG1136	(ABC) transporter
AMET_RS23705	COG0577	efflux transmembrane transporter activity
AMET_RS23710	COG5002	protein histidine kinase activity
AMET_RS23715	COG0745	RESPONSE REGULATOR receiver
AMET_RS23720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AMET_RS23725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMET_RS23730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AMET_RS23760	COG0745	RESPONSE REGULATOR receiver
AMET_RS23770	COG1404	Belongs to the peptidase S8 family
AMET_RS23775	COG0739	heme binding
AMET_RS23805	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AMET_RS23820	COG0305	Participates in initiation and elongation during chromosome replication
AMET_RS23825	COG0359	binds to the 23S rRNA
AMET_RS23830	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AMET_RS23860	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AMET_RS23875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AMET_RS23880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AMET_RS23885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AMET_RS23900	COG3949	Membrane
AMET_RS23915	COG1597	lipid kinase activity
AMET_RS23925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMET_RS23930	COG0384	phenazine biosynthesis protein PhzF
AMET_RS23935	COG1475	DNA binding
AMET_RS23940	COG1192	Involved in chromosome partitioning
AMET_RS23955	COG0357	Ribosomal RNA small subunit methyltransferase G
AMET_RS23960	COG0445	tRNA wobble uridine modification
AMET_RS23965	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AMET_RS23970	COG1847	R3H domain protein
AMET_RS23975	COG0706	membrane insertase activity
AMET_RS23980	COG0594	ribonuclease P activity
AMET_RS23985	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AMET_RS24015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMET_RS24030	COG4537	Required for transformation and DNA binding
AMET_RS24045	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AMET_RS24050	COG3266	domain, Protein
AMET_RS24050	COG2911	Protein conserved in bacteria
AMET_RS24050	COG1361	Conserved repeat domain
AMET_RS24055	COG1361	Conserved repeat domain
AMET_RS24090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMET_RS24135	COG0246	Mannitol dehydrogenase
AMET_RS24140	COG1555	photosystem II stabilization
AMET_RS24140	COG1596	polysaccharide export
AMET_RS24150	COG0840	transmembrane signaling receptor activity
AMET_RS24155	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AMET_RS24155	COG2199	diguanylate cyclase activity
AMET_RS24165	COG2972	Histidine kinase
AMET_RS24175	COG0803	Belongs to the bacterial solute-binding protein 9 family
AMET_RS24190	COG3437	response regulator, receiver
AMET_RS24195	COG5002	protein histidine kinase activity
AMET_RS24200	COG0658	competence protein
AMET_RS24200	COG2333	competence protein COMEC
AMET_RS24205	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMET_RS24240	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AMET_RS24260	COG0726	polysaccharide deacetylase
AMET_RS24350	COG1316	TRANSCRIPTIONal
AMET_RS24385	COG5484	DNA packaging
AMET_RS24395	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AMET_RS24410	COG0840	transmembrane signaling receptor activity
AMET_RS24425	COG1376	ErfK ybiS ycfS ynhG family protein
AMET_RS24430	COG3773	Cell wall hydrolase
AMET_RS24440	COG0745	RESPONSE REGULATOR receiver
AMET_RS24445	COG5001	Diguanylate cyclase
AMET_RS24450	COG0791	NLP P60 protein
AMET_RS24450	COG1388	LysM domain
AMET_RS24465	COG2897	thiosulfate sulfurtransferase activity
AMET_RS24470	COG2897	thiosulfate sulfurtransferase activity
AMET_RS24475	COG3835	regulator
AMET_RS24495	COG2226	methyltransferase
AMET_RS24500	COG2234	aminopeptidase activity
AMET_RS24525	COG1309	transcriptional regulator
AMET_RS24605	COG3852	Histidine kinase
AMET_RS24625	COG5002	protein histidine kinase activity
AMET_RS24630	COG5002	protein histidine kinase activity
AMET_RS24635	COG5002	protein histidine kinase activity
AMET_RS24645	COG1846	Transcriptional regulator
AMET_RS24670	COG4129	membrane