locus-tag	class	description
CLOS_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLOS_RS00020	COG0592	DNA-directed DNA polymerase activity
CLOS_RS00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLOS_RS00040	COG0187	DNA topoisomerase II activity
CLOS_RS00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLOS_RS00050	COG1366	Belongs to the anti-sigma-factor antagonist family
CLOS_RS00055	COG2172	sigma factor antagonist activity
CLOS_RS00060	COG1191	sigma factor activity
CLOS_RS00080	COG1827	regulation of RNA biosynthetic process
CLOS_RS00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLOS_RS00115	COG0590	tRNA wobble adenosine to inosine editing
CLOS_RS00125	COG0095	Lipoate-protein ligase
CLOS_RS00140	COG0425	Belongs to the sulfur carrier protein TusA family
CLOS_RS00155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLOS_RS00160	COG3290	protein histidine kinase activity
CLOS_RS00160	COG3829	transcription factor binding
CLOS_RS00165	COG4656	Part of a membrane complex involved in electron transport
CLOS_RS00170	COG5275	peptidyl-tyrosine sulfation
CLOS_RS00170	COG0252	asparaginase activity
CLOS_RS00180	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CLOS_RS00185	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CLOS_RS00190	COG0252	asparaginase activity
CLOS_RS00190	COG5275	peptidyl-tyrosine sulfation
CLOS_RS00195	COG5275	peptidyl-tyrosine sulfation
CLOS_RS00195	COG0252	asparaginase activity
CLOS_RS00210	COG0360	Binds together with S18 to 16S ribosomal RNA
CLOS_RS00220	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLOS_RS00245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLOS_RS00255	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CLOS_RS00260	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CLOS_RS00340	COG0840	transmembrane signaling receptor activity
CLOS_RS00345	COG1937	Protein conserved in bacteria
CLOS_RS00360	COG4977	sequence-specific DNA binding
CLOS_RS00360	COG1917	Cupin 2, conserved barrel domain protein
CLOS_RS00365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CLOS_RS00385	COG1982	Orn Lys Arg decarboxylase major
CLOS_RS00390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CLOS_RS00395	COG3870	Protein conserved in bacteria
CLOS_RS00405	COG1774	PSP1 C-terminal conserved region
CLOS_RS00410	COG0493	'glutamate synthase
CLOS_RS00415	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CLOS_RS00420	COG0509	glycine decarboxylation via glycine cleavage system
CLOS_RS00425	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLOS_RS00430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLOS_RS00450	COG3426	butyrate kinase activity
CLOS_RS00455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLOS_RS00470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLOS_RS00485	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CLOS_RS00495	COG0646	methionine synthase
CLOS_RS00495	COG1410	methionine synthase
CLOS_RS00505	COG1695	Transcriptional regulator
CLOS_RS00515	COG0183	Belongs to the thiolase family
CLOS_RS00520	COG3290	protein histidine kinase activity
CLOS_RS00520	COG3829	transcription factor binding
CLOS_RS00530	COG2610	gluconate transmembrane transporter activity
CLOS_RS00535	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLOS_RS00540	COG1028	Short-chain dehydrogenase reductase Sdr
CLOS_RS00545	COG2030	dehydratase
CLOS_RS00550	COG1960	acyl-CoA dehydrogenase activity
CLOS_RS00555	COG2086	electron transfer activity
CLOS_RS00560	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLOS_RS00570	COG0745	RESPONSE REGULATOR receiver
CLOS_RS00575	COG5002	protein histidine kinase activity
CLOS_RS00595	COG0488	(ABC) transporter
CLOS_RS00620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CLOS_RS00645	COG3340	Belongs to the peptidase S51 family
CLOS_RS00685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLOS_RS00690	COG0745	RESPONSE REGULATOR receiver
CLOS_RS00705	COG2205	protein histidine kinase activity
CLOS_RS00710	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLOS_RS00715	COG2011	ABC-type metal ion transport system permease component
CLOS_RS00720	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CLOS_RS00725	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CLOS_RS00730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLOS_RS00790	COG1136	(ABC) transporter
CLOS_RS00795	COG0577	efflux transmembrane transporter activity
CLOS_RS00810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLOS_RS00825	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CLOS_RS00830	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CLOS_RS00850	COG2801	Transposase and inactivated derivatives
CLOS_RS00865	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLOS_RS00905	COG1595	DNA-templated transcription, initiation
CLOS_RS00915	COG1024	Enoyl-CoA hydratase
CLOS_RS00920	COG2610	gluconate transmembrane transporter activity
CLOS_RS00935	COG2086	electron transfer activity
CLOS_RS00940	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLOS_RS00945	COG3290	protein histidine kinase activity
CLOS_RS00945	COG3829	transcription factor binding
CLOS_RS00955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLOS_RS00955	COG0723	plastoquinol--plastocyanin reductase activity
CLOS_RS00970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLOS_RS00975	COG0534	Mate efflux family protein
CLOS_RS00980	COG1053	succinate dehydrogenase
CLOS_RS00980	COG3976	FMN-binding domain protein
CLOS_RS00985	COG2972	Histidine kinase
CLOS_RS00990	COG2207	Transcriptional regulator
CLOS_RS00990	COG4753	response regulator
CLOS_RS01000	COG0739	heme binding
CLOS_RS01005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOS_RS01010	COG0765	amino acid transport
CLOS_RS01015	COG1126	abc transporter atp-binding protein
CLOS_RS01020	COG0840	transmembrane signaling receptor activity
CLOS_RS01025	COG3829	transcription factor binding
CLOS_RS01030	COG1115	amino acid carrier protein
CLOS_RS01035	COG4187	Peptidase family M20/M25/M40
CLOS_RS01040	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CLOS_RS01045	COG1687	branched-chain amino acid
CLOS_RS01060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOS_RS01065	COG1120	ATPase activity
CLOS_RS01085	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOS_RS01095	COG4191	Histidine kinase
CLOS_RS01100	COG2204	response regulator
CLOS_RS01125	COG0746	molybdenum cofactor guanylyltransferase activity
CLOS_RS01135	COG0303	'Molybdopterin
CLOS_RS01150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOS_RS01155	COG1120	ATPase activity
CLOS_RS01160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLOS_RS01170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLOS_RS01185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLOS_RS01190	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CLOS_RS01215	COG0010	Belongs to the arginase family
CLOS_RS01235	COG5002	protein histidine kinase activity
CLOS_RS01240	COG2502	aspartate--ammonia ligase
CLOS_RS01245	COG1132	(ABC) transporter
CLOS_RS01270	COG1013	pyruvate-flavodoxin oxidoreductase activity
CLOS_RS01270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOS_RS01270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CLOS_RS01270	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLOS_RS01275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLOS_RS01280	COG2033	superoxide reductase activity
CLOS_RS01290	COG0840	transmembrane signaling receptor activity
CLOS_RS01295	COG0653	protein targeting
CLOS_RS01310	COG0243	molybdopterin cofactor binding
CLOS_RS01330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLOS_RS01335	COG0840	transmembrane signaling receptor activity
CLOS_RS01355	COG1971	Probably functions as a manganese efflux pump
CLOS_RS01365	COG0628	permease
CLOS_RS01370	COG1028	Short-chain dehydrogenase reductase Sdr
CLOS_RS01375	COG0183	Belongs to the thiolase family
CLOS_RS01385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLOS_RS01410	COG0840	transmembrane signaling receptor activity
CLOS_RS01415	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLOS_RS01425	COG0581	inorganic phosphate transmembrane transporter activity
CLOS_RS01430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLOS_RS01435	COG0704	Plays a role in the regulation of phosphate uptake
CLOS_RS01440	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CLOS_RS01455	COG1757	Na H antiporter
CLOS_RS01475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CLOS_RS01480	COG2385	sporulation resulting in formation of a cellular spore
CLOS_RS01485	COG4466	Protein conserved in bacteria
CLOS_RS01500	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CLOS_RS01505	COG1802	Transcriptional regulator
CLOS_RS01520	COG0697	spore germination
CLOS_RS01525	COG0814	amino acid
CLOS_RS01540	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLOS_RS01555	COG3835	regulator
CLOS_RS01565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLOS_RS01570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLOS_RS01575	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOS_RS01585	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLOS_RS01595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLOS_RS01615	COG2207	Transcriptional regulator
CLOS_RS01625	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CLOS_RS01635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOS_RS01665	COG0697	spore germination
CLOS_RS01675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOS_RS01680	COG1120	ATPase activity
CLOS_RS01685	COG1131	(ABC) transporter
CLOS_RS01690	COG0842	Transport permease protein
CLOS_RS01700	COG0745	RESPONSE REGULATOR receiver
CLOS_RS01705	COG5002	protein histidine kinase activity
CLOS_RS01710	COG1803	Methylglyoxal synthase
CLOS_RS01735	COG0534	Mate efflux family protein
CLOS_RS01765	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CLOS_RS01780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CLOS_RS01785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLOS_RS01820	COG2153	protein acetylation
CLOS_RS01850	COG0840	transmembrane signaling receptor activity
CLOS_RS01855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLOS_RS01870	COG0322	excinuclease ABC activity
CLOS_RS01885	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CLOS_RS01900	COG1335	isochorismatase
CLOS_RS01905	COG0163	prenyltransferase activity
CLOS_RS01910	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CLOS_RS01925	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CLOS_RS01945	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CLOS_RS01950	COG2252	PERMEase
CLOS_RS01955	COG0402	S-adenosylhomocysteine deaminase activity
CLOS_RS01980	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CLOS_RS01995	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CLOS_RS02000	COG1982	Orn Lys Arg decarboxylase major
CLOS_RS02005	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CLOS_RS02015	COG1607	acyl-coa hydrolase
CLOS_RS02025	COG0745	RESPONSE REGULATOR receiver
CLOS_RS02040	COG1902	pentaerythritol trinitrate reductase activity
CLOS_RS02060	COG0439	Biotin carboxylase
CLOS_RS02065	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLOS_RS02070	COG0825	malonyl-CoA metabolic process
CLOS_RS02080	COG1272	protein, Hemolysin III
CLOS_RS02090	COG1619	proteins homologs of microcin C7 resistance protein MccF
CLOS_RS02095	COG1473	amidohydrolase
CLOS_RS02105	COG2210	Belongs to the sulfur carrier protein TusA family
CLOS_RS02120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLOS_RS02125	COG1388	LysM domain
CLOS_RS02125	COG3858	chitin binding
CLOS_RS02135	COG2199	diguanylate cyclase activity
CLOS_RS02140	COG0116	Belongs to the methyltransferase superfamily
CLOS_RS02155	COG1408	metallophosphoesterase
CLOS_RS02160	COG3829	transcription factor binding
CLOS_RS02165	COG0604	alcohol dehydrogenase
CLOS_RS02180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLOS_RS02185	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CLOS_RS02190	COG5012	cobalamin binding
CLOS_RS02210	COG3279	Response regulator of the LytR AlgR family
CLOS_RS02235	COG0037	tRNA processing
CLOS_RS02240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLOS_RS02255	COG0427	acetyl-CoA hydrolase
CLOS_RS02260	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CLOS_RS02260	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CLOS_RS02265	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CLOS_RS02265	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CLOS_RS02275	COG0346	lactoylglutathione lyase activity
CLOS_RS02280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CLOS_RS02290	COG4770	biotin carboxylase activity
CLOS_RS02295	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CLOS_RS02300	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CLOS_RS02300	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CLOS_RS02310	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CLOS_RS02315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLOS_RS02325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLOS_RS02330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CLOS_RS02355	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLOS_RS02360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLOS_RS02365	COG3880	PFAM UvrB UvrC protein
CLOS_RS02370	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CLOS_RS02375	COG0542	response to heat
CLOS_RS02380	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CLOS_RS02395	COG1329	Transcriptional regulator
CLOS_RS02400	COG4956	integral membrane protein (PIN domain superfamily)
CLOS_RS02410	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLOS_RS02415	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CLOS_RS02420	COG0442	prolyl-tRNA aminoacylation
CLOS_RS02425	COG4086	secreted protein
CLOS_RS02430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLOS_RS02435	COG1045	serine acetyltransferase
CLOS_RS02440	COG0215	cysteine-tRNA ligase activity
CLOS_RS02460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLOS_RS02465	COG3688	RNA-binding protein containing a PIN domain
CLOS_RS02475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLOS_RS02480	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLOS_RS02490	COG0250	Participates in transcription elongation, termination and antitermination
CLOS_RS02495	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CLOS_RS02500	COG0081	regulation of translation
CLOS_RS02505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CLOS_RS02510	COG0222	ribosome binding
CLOS_RS02515	COG0085	RNA polymerase activity
CLOS_RS02520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLOS_RS02525	COG1358	cellular component organization or biogenesis
CLOS_RS02530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CLOS_RS02535	COG0049	tRNA binding
CLOS_RS02540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLOS_RS02545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLOS_RS02550	COG0051	transcription antitermination factor activity, RNA binding
CLOS_RS02555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLOS_RS02560	COG0088	Forms part of the polypeptide exit tunnel
CLOS_RS02565	COG0089	rRNA binding
CLOS_RS02570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CLOS_RS02575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CLOS_RS02580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CLOS_RS02585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CLOS_RS02590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLOS_RS02595	COG0255	Belongs to the universal ribosomal protein uL29 family
CLOS_RS02600	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLOS_RS02605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CLOS_RS02610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CLOS_RS02615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CLOS_RS02620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CLOS_RS02625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CLOS_RS02630	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CLOS_RS02635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLOS_RS02640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CLOS_RS02645	COG1841	ribosomal large subunit assembly
CLOS_RS02650	COG0200	Binds to the 23S rRNA
CLOS_RS02655	COG0201	protein transport
CLOS_RS02660	COG0563	adenylate kinase activity
CLOS_RS02665	COG0024	Methionine aminopeptidase
CLOS_RS02675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CLOS_RS02680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CLOS_RS02685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLOS_RS02690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLOS_RS02695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLOS_RS02700	COG0202	RNA polymerase activity
CLOS_RS02705	COG0203	ribosomal protein L17
CLOS_RS02710	COG1122	ATPase activity
CLOS_RS02720	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CLOS_RS02730	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CLOS_RS02735	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLOS_RS02745	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLOS_RS02760	COG0517	IMP dehydrogenase activity
CLOS_RS02760	COG0516	GMP reductase activity
CLOS_RS02770	COG2252	PERMEase
CLOS_RS02775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CLOS_RS02780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CLOS_RS02785	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CLOS_RS02790	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLOS_RS02795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLOS_RS02800	COG0138	bifunctional purine biosynthesis protein purh
CLOS_RS02805	COG0151	Belongs to the GarS family
CLOS_RS02815	COG0840	transmembrane signaling receptor activity
CLOS_RS02825	COG0527	aspartate kinase activity
CLOS_RS02835	COG1301	dicarboxylic acid transport
CLOS_RS02840	COG1794	racemase activity, acting on amino acids and derivatives
CLOS_RS02845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLOS_RS02850	COG0210	DNA helicase
CLOS_RS02855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLOS_RS02870	COG3069	C4-dicarboxylate transmembrane transporter activity
CLOS_RS02885	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CLOS_RS02900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CLOS_RS02905	COG0622	Phosphoesterase
CLOS_RS02960	COG2135	peptidase activity
CLOS_RS02980	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOS_RS02990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CLOS_RS02995	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLOS_RS03010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CLOS_RS03015	COG1660	Displays ATPase and GTPase activities
CLOS_RS03020	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CLOS_RS03025	COG2233	PERMEase
CLOS_RS03035	COG1481	regulation of sporulation
CLOS_RS03040	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CLOS_RS03055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLOS_RS03070	COG0205	6-phosphofructokinase activity
CLOS_RS03080	COG1309	transcriptional regulator
CLOS_RS03085	COG3976	FMN-binding domain protein
CLOS_RS03085	COG1053	succinate dehydrogenase
CLOS_RS03085	COG0431	NADPH-dependent FMN reductase
CLOS_RS03120	COG2801	Transposase and inactivated derivatives
CLOS_RS03145	COG1660	Displays ATPase and GTPase activities
CLOS_RS03150	COG1910	domain protein
CLOS_RS03195	COG2205	protein histidine kinase activity
CLOS_RS03200	COG0745	RESPONSE REGULATOR receiver
CLOS_RS03230	COG1592	Rubrerythrin
CLOS_RS03245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOS_RS03255	COG0569	domain protein
CLOS_RS03255	COG2985	domain, Protein
CLOS_RS03260	COG0045	succinate-CoA ligase (ADP-forming) activity
CLOS_RS03265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CLOS_RS03275	COG1012	belongs to the aldehyde dehydrogenase family
CLOS_RS03285	COG1609	Transcriptional regulator
CLOS_RS03290	COG3845	ABC transporter
CLOS_RS03305	COG1393	Belongs to the ArsC family
CLOS_RS03320	COG2031	fatty acid transporter
CLOS_RS03325	COG1960	acyl-CoA dehydrogenase activity
CLOS_RS03330	COG2086	electron transfer activity
CLOS_RS03335	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLOS_RS03340	COG0463	Glycosyl transferase, family 2
CLOS_RS03340	COG0457	Tetratricopeptide repeat
CLOS_RS03355	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CLOS_RS03360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLOS_RS03370	COG2188	Transcriptional regulator
CLOS_RS03400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLOS_RS03405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLOS_RS03405	COG1522	sequence-specific DNA binding
CLOS_RS03415	COG3118	belongs to the thioredoxin family
CLOS_RS03420	COG0492	ferredoxin-NADP+ reductase activity
CLOS_RS03425	COG0428	transporter
CLOS_RS03440	COG1164	Oligoendopeptidase f
CLOS_RS03450	COG2884	Cell division ATP-binding protein ftsE
CLOS_RS03455	COG2177	Part of the ABC transporter FtsEX involved in
CLOS_RS03460	COG0546	phosphoglycolate phosphatase activity
CLOS_RS03475	COG0789	Transcriptional regulator
CLOS_RS03485	COG0745	RESPONSE REGULATOR receiver
CLOS_RS03500	COG1151	hydroxylamine reductase activity
CLOS_RS03505	COG4536	flavin adenine dinucleotide binding
CLOS_RS03510	COG0488	(ABC) transporter
CLOS_RS03515	COG0569	domain protein
CLOS_RS03520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CLOS_RS03525	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CLOS_RS03530	COG2358	TRAP transporter, solute receptor (TAXI family
CLOS_RS03545	COG2364	Membrane
CLOS_RS03550	COG1876	peptidase activity
CLOS_RS03560	COG2207	Transcriptional regulator
CLOS_RS03565	COG1132	(ABC) transporter
CLOS_RS03565	COG2375	cellular response to nickel ion
CLOS_RS03570	COG1132	(ABC) transporter
CLOS_RS03585	COG1649	PFAM Uncharacterised BCR, COG1649
CLOS_RS03590	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CLOS_RS03590	COG0116	Belongs to the methyltransferase superfamily
CLOS_RS03595	COG0564	pseudouridine synthase activity
CLOS_RS03600	COG3973	AAA domain
CLOS_RS03605	COG1979	alcohol dehydrogenase
CLOS_RS03615	COG1595	DNA-templated transcription, initiation
CLOS_RS03635	COG3853	Toxic anion resistance protein (TelA)
CLOS_RS03650	COG2310	stress, protein
CLOS_RS03655	COG2310	stress, protein
CLOS_RS03670	COG1131	(ABC) transporter
CLOS_RS03685	COG1131	(ABC) transporter
CLOS_RS03700	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CLOS_RS03705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLOS_RS03720	COG1242	4 iron, 4 sulfur cluster binding
CLOS_RS03730	COG2357	RelA SpoT domain protein
CLOS_RS03740	COG0191	fructose-bisphosphate aldolase activity
CLOS_RS03745	COG1183	phosphatidylcholine synthase activity
CLOS_RS03750	COG1187	pseudouridine synthase activity
CLOS_RS03755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOS_RS03760	COG0765	amino acid transport
CLOS_RS03770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLOS_RS03775	COG0745	RESPONSE REGULATOR receiver
CLOS_RS03785	COG1136	(ABC) transporter
CLOS_RS03785	COG0577	efflux transmembrane transporter activity
CLOS_RS03820	COG2801	Transposase and inactivated derivatives
CLOS_RS03860	COG0583	DNA-binding transcription factor activity
CLOS_RS03865	COG0384	phenazine biosynthesis protein PhzF
CLOS_RS03875	COG4191	Histidine kinase
CLOS_RS03885	COG1115	amino acid carrier protein
CLOS_RS03895	COG1309	transcriptional regulator
CLOS_RS03910	COG1136	(ABC) transporter
CLOS_RS03915	COG0789	Transcriptional regulator
CLOS_RS03925	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CLOS_RS03935	COG4716	Myosin-crossreactive antigen
CLOS_RS03940	COG0714	Associated with various cellular activities
CLOS_RS03950	COG2304	oxidoreductase activity
CLOS_RS03965	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CLOS_RS03980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLOS_RS04005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CLOS_RS04020	COG2155	Conserved Protein
CLOS_RS04025	COG1396	sequence-specific DNA binding
CLOS_RS04050	COG1595	DNA-templated transcription, initiation
CLOS_RS04065	COG1846	Transcriptional regulator
CLOS_RS04075	COG0745	RESPONSE REGULATOR receiver
CLOS_RS04080	COG5002	protein histidine kinase activity
CLOS_RS04100	COG4917	ethanolamine utilization protein
CLOS_RS04105	COG2096	Adenosyltransferase
CLOS_RS04140	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CLOS_RS04145	COG1012	belongs to the aldehyde dehydrogenase family
CLOS_RS04145	COG1454	alcohol dehydrogenase
CLOS_RS04160	COG4869	propanediol catabolic process
CLOS_RS04170	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CLOS_RS04175	COG3192	ethanolamine utilization protein
CLOS_RS04205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CLOS_RS04215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLOS_RS04220	COG2378	regulation of single-species biofilm formation
CLOS_RS04260	COG4978	Transcriptional regulator
CLOS_RS04260	COG0789	Transcriptional regulator
CLOS_RS04265	COG1408	metallophosphoesterase
CLOS_RS04280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLOS_RS04285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLOS_RS04295	COG2059	Chromate
CLOS_RS04305	COG0583	DNA-binding transcription factor activity
CLOS_RS04310	COG0783	Belongs to the Dps family
CLOS_RS04320	COG0596	Alpha beta hydrolase
CLOS_RS04350	COG2720	vancomycin resistance protein
CLOS_RS04360	COG1982	Orn Lys Arg decarboxylase major
CLOS_RS04375	COG3314	Sporulation integral membrane protein YlbJ
CLOS_RS04385	COG0604	alcohol dehydrogenase
CLOS_RS04390	COG1846	Transcriptional regulator
CLOS_RS04395	COG1028	Short-chain dehydrogenase reductase Sdr
CLOS_RS04400	COG3274	enterobacterial common antigen metabolic process
CLOS_RS04415	COG0662	Cupin 2, conserved barrel domain protein
CLOS_RS04420	COG2508	Transcriptional regulator
CLOS_RS04440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CLOS_RS04450	COG2205	protein histidine kinase activity
CLOS_RS04455	COG0745	RESPONSE REGULATOR receiver
CLOS_RS04465	COG1492	cobalamin metabolic process
CLOS_RS04470	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CLOS_RS04475	COG0531	amino acid
CLOS_RS04485	COG2233	PERMEase
CLOS_RS04490	COG2508	Transcriptional regulator
CLOS_RS04495	COG3835	regulator
CLOS_RS04505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CLOS_RS04510	COG1304	FMN binding
CLOS_RS04520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLOS_RS04545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLOS_RS04550	COG0840	transmembrane signaling receptor activity
CLOS_RS04555	COG1971	Probably functions as a manganese efflux pump
CLOS_RS04560	COG0534	Mate efflux family protein
CLOS_RS04565	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CLOS_RS04575	COG0028	Belongs to the TPP enzyme family
CLOS_RS04595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLOS_RS04600	COG0482	sulfurtransferase activity
CLOS_RS04620	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOS_RS04630	COG0840	transmembrane signaling receptor activity
CLOS_RS04635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLOS_RS04640	COG3546	catalase activity
CLOS_RS04675	COG0681	Belongs to the peptidase S26 family
CLOS_RS04680	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLOS_RS04685	COG1067	ATP-dependent peptidase activity
CLOS_RS04690	COG0156	8-amino-7-oxononanoate synthase activity
CLOS_RS04695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLOS_RS04705	COG2720	vancomycin resistance protein
CLOS_RS04720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLOS_RS04725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOS_RS04730	COG1120	ATPase activity
CLOS_RS04735	COG0735	belongs to the Fur family
CLOS_RS04740	COG0561	phosphatase activity
CLOS_RS04745	COG0737	Belongs to the 5'-nucleotidase family
CLOS_RS04780	COG4948	Mandelate Racemase Muconate Lactonizing
CLOS_RS04815	COG1116	anion transmembrane transporter activity
CLOS_RS04820	COG0668	transmembrane transport
CLOS_RS04825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLOS_RS04830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CLOS_RS04845	COG1595	DNA-templated transcription, initiation
CLOS_RS04860	COG0745	RESPONSE REGULATOR receiver
CLOS_RS04865	COG5002	protein histidine kinase activity
CLOS_RS04870	COG0488	(ABC) transporter
CLOS_RS04875	COG1968	undecaprenyl-diphosphatase activity
CLOS_RS04890	COG4139	cobalamin transport
CLOS_RS04895	COG1120	ATPase activity
CLOS_RS04905	COG1307	EDD domain protein, DegV family
CLOS_RS04920	COG3118	belongs to the thioredoxin family
CLOS_RS04945	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CLOS_RS04960	COG1744	ABC transporter substrate-binding protein PnrA-like
CLOS_RS04965	COG1328	CTP reductase activity
CLOS_RS04970	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CLOS_RS04975	COG3845	ABC transporter
CLOS_RS04980	COG4603	Belongs to the binding-protein-dependent transport system permease family
CLOS_RS04985	COG1079	Belongs to the binding-protein-dependent transport system permease family
CLOS_RS04990	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CLOS_RS05000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CLOS_RS05005	COG0126	phosphoglycerate kinase activity
CLOS_RS05010	COG0149	triose-phosphate isomerase activity
CLOS_RS05015	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CLOS_RS05020	COG0148	phosphopyruvate hydratase activity
CLOS_RS05035	COG3326	Membrane
CLOS_RS05040	COG0557	exoribonuclease II activity
CLOS_RS05045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CLOS_RS05050	COG0514	ATP-dependent DNA helicase (RecQ)
CLOS_RS05055	COG1136	(ABC) transporter
CLOS_RS05060	COG0577	efflux transmembrane transporter activity
CLOS_RS05065	COG0745	RESPONSE REGULATOR receiver
CLOS_RS05085	COG0542	response to heat
CLOS_RS05110	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLOS_RS05120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLOS_RS05125	COG0564	pseudouridine synthase activity
CLOS_RS05130	COG0500	methyltransferase
CLOS_RS05135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLOS_RS05140	COG2205	protein histidine kinase activity
CLOS_RS05150	COG2200	EAL domain
CLOS_RS05160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOS_RS05160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOS_RS05165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLOS_RS05170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOS_RS05180	COG0500	methyltransferase
CLOS_RS05185	COG2362	D-Aminopeptidase
CLOS_RS05210	COG0310	cobalt ion transport
CLOS_RS05215	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
CLOS_RS05225	COG1122	ATPase activity
CLOS_RS05235	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CLOS_RS05275	COG2059	Chromate
CLOS_RS05285	COG0583	DNA-binding transcription factor activity
CLOS_RS05290	COG2391	methyltransferase activity
CLOS_RS05300	COG2391	methyltransferase activity
CLOS_RS05355	COG0037	tRNA processing
CLOS_RS05360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CLOS_RS05380	COG1983	PspC domain protein
CLOS_RS05395	COG2268	Band 7 protein
CLOS_RS05405	COG0582	viral genome integration into host DNA
CLOS_RS05415	COG1396	sequence-specific DNA binding
CLOS_RS05445	COG1484	DNA-dependent DNA replication
CLOS_RS05460	COG0840	transmembrane signaling receptor activity
CLOS_RS05510	COG2217	Heavy metal translocating P-type atpase
CLOS_RS05545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLOS_RS05550	COG0626	cystathionine gamma-synthase activity
CLOS_RS05555	COG1854	S-ribosylhomocysteine lyase activity
CLOS_RS05560	COG2226	methyltransferase
CLOS_RS05570	COG3852	Histidine kinase
CLOS_RS05575	COG2204	response regulator
CLOS_RS05595	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CLOS_RS05600	COG2264	protein methyltransferase activity
CLOS_RS05615	COG2217	Heavy metal translocating P-type atpase
CLOS_RS05640	COG1131	(ABC) transporter
CLOS_RS05650	COG1595	DNA-templated transcription, initiation
CLOS_RS05655	COG2226	methyltransferase
CLOS_RS05660	COG0746	molybdenum cofactor guanylyltransferase activity
CLOS_RS05665	COG0243	molybdopterin cofactor binding
CLOS_RS05670	COG0437	4 iron, 4 sulfur cluster binding
CLOS_RS05680	COG0437	4 iron, 4 sulfur cluster binding
CLOS_RS05690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLOS_RS05700	COG0303	'Molybdopterin
CLOS_RS05755	COG0798	PFAM Bile acid sodium symporter
CLOS_RS05765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLOS_RS05770	COG0573	inorganic phosphate transmembrane transporter activity
CLOS_RS05775	COG0581	inorganic phosphate transmembrane transporter activity
CLOS_RS05780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLOS_RS05785	COG0704	Plays a role in the regulation of phosphate uptake
CLOS_RS05800	COG0701	Predicted permease
CLOS_RS05845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLOS_RS05855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLOS_RS05865	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CLOS_RS05885	COG1285	pathogenesis
CLOS_RS05950	COG2333	competence protein COMEC
CLOS_RS05950	COG0658	competence protein
CLOS_RS05960	COG0588	phosphoglycerate mutase activity
CLOS_RS05980	COG2094	Belongs to the DNA glycosylase MPG family
CLOS_RS05985	COG1304	FMN binding
CLOS_RS05990	COG0726	polysaccharide deacetylase
CLOS_RS06000	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CLOS_RS06005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLOS_RS06010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLOS_RS06025	COG1164	Oligoendopeptidase f
CLOS_RS06045	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CLOS_RS06050	COG0564	pseudouridine synthase activity
CLOS_RS06060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLOS_RS06080	COG2244	polysaccharide biosynthetic process
CLOS_RS06085	COG2199	diguanylate cyclase activity
CLOS_RS06095	COG1132	(ABC) transporter
CLOS_RS06100	COG1132	(ABC) transporter
CLOS_RS06110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLOS_RS06115	COG1597	lipid kinase activity
CLOS_RS06120	COG1846	Transcriptional regulator
CLOS_RS06125	COG2199	diguanylate cyclase activity
CLOS_RS06125	COG2203	Gaf domain
CLOS_RS06130	COG2986	histidine ammonia-lyase
CLOS_RS06135	COG1228	amidohydrolase
CLOS_RS06150	COG0835	chemotaxis
CLOS_RS06165	COG2197	response regulator
CLOS_RS06170	COG1307	EDD domain protein, DegV family
CLOS_RS06175	COG0583	DNA-binding transcription factor activity
CLOS_RS06180	COG2357	RelA SpoT domain protein
CLOS_RS06195	COG1136	(ABC) transporter
CLOS_RS06200	COG1136	(ABC) transporter
CLOS_RS06200	COG0577	efflux transmembrane transporter activity
CLOS_RS06210	COG5002	protein histidine kinase activity
CLOS_RS06220	COG1595	DNA-templated transcription, initiation
CLOS_RS06230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLOS_RS06230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLOS_RS06260	COG0242	peptide deformylase activity
CLOS_RS06265	COG0402	S-adenosylhomocysteine deaminase activity
CLOS_RS06270	COG2703	oxygen carrier activity
CLOS_RS06290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CLOS_RS06295	COG0513	Belongs to the DEAD box helicase family
CLOS_RS06310	COG2333	competence protein COMEC
CLOS_RS06310	COG0658	competence protein
CLOS_RS06320	COG2333	competence protein COMEC
CLOS_RS06320	COG0658	competence protein
CLOS_RS06330	COG0268	Binds directly to 16S ribosomal RNA
CLOS_RS06350	COG0481	GTPase activity
CLOS_RS06355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLOS_RS06360	COG1420	regulation of RNA biosynthetic process
CLOS_RS06365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLOS_RS06370	COG0443	Heat shock 70 kDa protein
CLOS_RS06375	COG0484	heat shock protein binding
CLOS_RS06380	COG2264	protein methyltransferase activity
CLOS_RS06385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLOS_RS06390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLOS_RS06395	COG0537	adenosine 5'-monophosphoramidase activity
CLOS_RS06400	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CLOS_RS06405	COG1610	YqeY-like protein
CLOS_RS06415	COG4864	UPF0365 protein
CLOS_RS06435	COG1702	phosphate starvation-inducible protein PhoH
CLOS_RS06440	COG1480	7TM receptor with intracellular HD hydrolase
CLOS_RS06445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLOS_RS06450	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CLOS_RS06460	COG0295	cytidine deaminase activity
CLOS_RS06465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLOS_RS06470	COG1381	Involved in DNA repair and RecF pathway recombination
CLOS_RS06475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLOS_RS06480	COG0423	glycine-tRNA ligase activity
CLOS_RS06485	COG0517	IMP dehydrogenase activity
CLOS_RS06490	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CLOS_RS06495	COG0574	Belongs to the PEP-utilizing enzyme family
CLOS_RS06495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLOS_RS06500	COG0519	Catalyzes the synthesis of GMP from XMP
CLOS_RS06560	COG1695	Transcriptional regulator
CLOS_RS06580	COG3655	Transcriptional regulator
CLOS_RS06595	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CLOS_RS06600	COG0358	DNA primase activity
CLOS_RS06605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLOS_RS06615	COG2384	SAM-dependent methyltransferase
CLOS_RS06620	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CLOS_RS06630	COG0582	viral genome integration into host DNA
CLOS_RS06640	COG1917	Cupin 2, conserved barrel domain protein
CLOS_RS06640	COG1396	sequence-specific DNA binding
CLOS_RS06675	COG0358	DNA primase activity
CLOS_RS06820	COG2003	Belongs to the UPF0758 family
CLOS_RS06830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CLOS_RS06835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CLOS_RS06840	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CLOS_RS06855	COG0181	hydroxymethylbilane synthase activity
CLOS_RS06865	COG0113	porphobilinogen synthase activity
CLOS_RS06870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLOS_RS06880	COG1970	mechanosensitive ion channel activity
CLOS_RS06890	COG1966	Carbon starvation protein
CLOS_RS06895	COG3279	Response regulator of the LytR AlgR family
CLOS_RS06900	COG3275	phosphorelay sensor kinase activity
CLOS_RS06920	COG0494	nUDIX hydrolase
CLOS_RS06930	COG0601	transmembrane transport
CLOS_RS06935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOS_RS06940	COG0444	Belongs to the ABC transporter superfamily
CLOS_RS06945	COG4608	Belongs to the ABC transporter superfamily
CLOS_RS06955	COG2030	dehydratase
CLOS_RS06960	COG0747	negative chemotaxis
CLOS_RS06965	COG0601	transmembrane transport
CLOS_RS06970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOS_RS06975	COG0444	Belongs to the ABC transporter superfamily
CLOS_RS06980	COG4608	Belongs to the ABC transporter superfamily
CLOS_RS06985	COG2096	Adenosyltransferase
CLOS_RS06990	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CLOS_RS07010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CLOS_RS07015	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLOS_RS07020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLOS_RS07025	COG4869	propanediol catabolic process
CLOS_RS07030	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CLOS_RS07045	COG0012	GTP binding
CLOS_RS07060	COG0612	Peptidase, M16
CLOS_RS07065	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CLOS_RS07070	COG2001	Belongs to the MraZ family
CLOS_RS07075	COG0275	rRNA processing
CLOS_RS07085	COG0768	penicillin binding
CLOS_RS07090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLOS_RS07095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLOS_RS07100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLOS_RS07105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLOS_RS07110	COG0772	Belongs to the SEDS family
CLOS_RS07115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLOS_RS07120	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLOS_RS07140	COG3856	small basic protein
CLOS_RS07145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CLOS_RS07155	COG1191	sigma factor activity
CLOS_RS07160	COG1191	sigma factor activity
CLOS_RS07165	COG1873	PFAM PRC-barrel domain
CLOS_RS07170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CLOS_RS07175	COG1496	oxidoreductase activity
CLOS_RS07180	COG0745	RESPONSE REGULATOR receiver
CLOS_RS07185	COG5002	protein histidine kinase activity
CLOS_RS07215	COG1160	GTP binding
CLOS_RS07220	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CLOS_RS07225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CLOS_RS07230	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CLOS_RS07255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLOS_RS07260	COG1799	cell septum assembly
CLOS_RS07270	COG2302	S4 RNA-binding domain
CLOS_RS07275	COG3599	regulation of cell shape
CLOS_RS07280	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CLOS_RS07285	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLOS_RS07295	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CLOS_RS07300	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CLOS_RS07305	COG0564	pseudouridine synthase activity
CLOS_RS07310	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CLOS_RS07320	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CLOS_RS07325	COG1561	YicC-like family, N-terminal region
CLOS_RS07330	COG2052	Domain of unknown function (DUF370)
CLOS_RS07335	COG0194	GDP metabolic process
CLOS_RS07340	COG1758	RNA polymerase activity
CLOS_RS07345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CLOS_RS07350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLOS_RS07355	COG0242	peptide deformylase activity
CLOS_RS07360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLOS_RS07370	COG2738	Putative neutral zinc metallopeptidase
CLOS_RS07375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLOS_RS07375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLOS_RS07380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CLOS_RS07385	COG0631	protein serine/threonine phosphatase activity
CLOS_RS07390	COG2815	serine threonine protein kinase
CLOS_RS07390	COG0515	serine threonine protein kinase
CLOS_RS07395	COG1162	GTPase activity
CLOS_RS07400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CLOS_RS07405	COG1564	THIamine pyrophosphokinase
CLOS_RS07410	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLOS_RS07415	COG1302	Protein conserved in bacteria
CLOS_RS07420	COG1461	Dihydroxyacetone kinase
CLOS_RS07425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLOS_RS07430	COG0742	ribosomal rna small subunit methyltransferase
CLOS_RS07435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLOS_RS07445	COG3314	Sporulation integral membrane protein YlbJ
CLOS_RS07450	COG1323	Belongs to the UPF0348 family
CLOS_RS07455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLOS_RS07465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CLOS_RS07470	COG2030	dehydratase
CLOS_RS07475	COG0416	fatty acid biosynthetic process
CLOS_RS07480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLOS_RS07485	COG2070	2-Nitropropane dioxygenase
CLOS_RS07490	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLOS_RS07495	COG1028	Short-chain dehydrogenase reductase Sdr
CLOS_RS07500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLOS_RS07505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLOS_RS07510	COG0571	ribonuclease III activity
CLOS_RS07520	COG1196	nuclear chromosome segregation
CLOS_RS07525	COG0552	protein localization to endoplasmic reticulum
CLOS_RS07535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLOS_RS07540	COG0228	four-way junction DNA binding
CLOS_RS07545	COG1837	Belongs to the UPF0109 family
CLOS_RS07550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CLOS_RS07555	COG0336	Belongs to the RNA methyltransferase TrmD family
CLOS_RS07560	COG0335	large ribosomal subunit rRNA binding
CLOS_RS07565	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CLOS_RS07570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CLOS_RS07575	COG0792	nuclease activity
CLOS_RS07585	COG0758	DNA mediated transformation
CLOS_RS07590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLOS_RS07600	COG1815	bacterial-type flagellum-dependent cell motility
CLOS_RS07605	COG1558	bacterial-type flagellum-dependent cell motility
CLOS_RS07610	COG1677	Flagellar hook-basal body complex protein FliE
CLOS_RS07615	COG1766	The M ring may be actively involved in energy transduction
CLOS_RS07620	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLOS_RS07630	COG1157	protein secretion by the type III secretion system
CLOS_RS07650	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CLOS_RS07670	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CLOS_RS07675	COG1360	Flagellar Motor Protein
CLOS_RS07690	COG1776	CheC inhibitor of MCP methylation
CLOS_RS07690	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLOS_RS07695	COG2201	protein-glutamate methylesterase activity
CLOS_RS07705	COG1338	Plays a role in the flagellum-specific transport system
CLOS_RS07710	COG1987	bacterial-type flagellum assembly
CLOS_RS07715	COG1684	flagellar biosynthetic protein fliR
CLOS_RS07720	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLOS_RS07725	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLOS_RS07730	COG1419	protein localization to endoplasmic reticulum
CLOS_RS07740	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CLOS_RS07745	COG2201	protein-glutamate methylesterase activity
CLOS_RS07750	COG2198	Histidine kinase
CLOS_RS07750	COG0643	Histidine kinase
CLOS_RS07755	COG0835	chemotaxis
CLOS_RS07760	COG1776	CheC inhibitor of MCP methylation
CLOS_RS07765	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CLOS_RS07770	COG1191	sigma factor activity
CLOS_RS07785	COG0052	Belongs to the universal ribosomal protein uS2 family
CLOS_RS07790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLOS_RS07795	COG0528	UMP kinase activity
CLOS_RS07800	COG0233	cytoplasmic translational termination
CLOS_RS07815	COG4589	Belongs to the CDS family
CLOS_RS07820	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CLOS_RS07825	COG0750	zinc metalloprotease
CLOS_RS07835	COG0463	Glycosyl transferase, family 2
CLOS_RS07845	COG0779	Required for maturation of 30S ribosomal subunits
CLOS_RS07850	COG0195	Participates in both transcription termination and antitermination
CLOS_RS07855	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CLOS_RS07865	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CLOS_RS07870	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CLOS_RS07875	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CLOS_RS07880	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CLOS_RS07885	COG0196	riboflavin kinase activity
CLOS_RS07890	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLOS_RS07895	COG1185	polyribonucleotide nucleotidyltransferase activity
CLOS_RS07900	COG0726	polysaccharide deacetylase
CLOS_RS07905	COG0612	Peptidase, M16
CLOS_RS07915	COG0740	serine-type endopeptidase activity
CLOS_RS07920	COG1674	ftsk spoiiie
CLOS_RS07925	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CLOS_RS07930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLOS_RS07940	COG1418	mRNA catabolic process
CLOS_RS07945	COG2359	stage V sporulation protein S
CLOS_RS07950	COG0613	PHP domain protein
CLOS_RS07960	COG3858	chitin binding
CLOS_RS07965	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CLOS_RS07970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLOS_RS07975	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CLOS_RS07980	COG1923	regulation of RNA biosynthetic process
CLOS_RS07985	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLOS_RS07990	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CLOS_RS07995	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLOS_RS08000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLOS_RS08015	COG1363	Peptidase, m42
CLOS_RS08020	COG1363	Peptidase, m42
CLOS_RS08025	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLOS_RS08030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLOS_RS08030	COG0539	negative regulation of cytoplasmic translation
CLOS_RS08035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLOS_RS08040	COG0204	Acyl-transferase
CLOS_RS08045	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CLOS_RS08055	COG2081	HI0933 family
CLOS_RS08060	COG0406	alpha-ribazole phosphatase activity
CLOS_RS08065	COG1737	Transcriptional regulator
CLOS_RS08075	COG1013	pyruvate-flavodoxin oxidoreductase activity
CLOS_RS08080	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CLOS_RS08080	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLOS_RS08100	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CLOS_RS08110	COG1187	pseudouridine synthase activity
CLOS_RS08115	COG0445	tRNA wobble uridine modification
CLOS_RS08125	COG1686	Belongs to the peptidase S11 family
CLOS_RS08135	COG3874	Sporulation protein YtfJ
CLOS_RS08150	COG0010	Belongs to the arginase family
CLOS_RS08155	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CLOS_RS08160	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CLOS_RS08165	COG1686	Belongs to the peptidase S11 family
CLOS_RS08175	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CLOS_RS08185	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CLOS_RS08190	COG4974	Belongs to the 'phage' integrase family
CLOS_RS08215	COG0463	Glycosyl transferase, family 2
CLOS_RS08230	COG2137	regulation of response to DNA damage stimulus
CLOS_RS08240	COG0750	zinc metalloprotease
CLOS_RS08245	COG0497	DNA recombination
CLOS_RS08250	COG1438	arginine binding
CLOS_RS08255	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CLOS_RS08260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLOS_RS08265	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CLOS_RS08270	COG0142	geranyltranstransferase activity
CLOS_RS08275	COG1722	exodeoxyribonuclease VII activity
CLOS_RS08280	COG1570	exodeoxyribonuclease VII activity
CLOS_RS08285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLOS_RS08290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLOS_RS08295	COG1302	Protein conserved in bacteria
CLOS_RS08335	COG3854	ATPases associated with a variety of cellular activities
CLOS_RS08345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CLOS_RS08350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CLOS_RS08375	COG1361	Conserved repeat domain
CLOS_RS08395	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CLOS_RS08405	COG1459	type II secretion system
CLOS_RS08415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLOS_RS08420	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CLOS_RS08500	COG0768	penicillin binding
CLOS_RS08505	COG0572	uridine kinase
CLOS_RS08510	COG0826	peptidase U32
CLOS_RS08515	COG4122	O-methyltransferase activity
CLOS_RS08530	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLOS_RS08535	COG0735	belongs to the Fur family
CLOS_RS08540	COG3906	Belongs to the UPF0473 family
CLOS_RS08545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CLOS_RS08555	COG4472	Bacterial protein of unknown function (DUF965)
CLOS_RS08560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLOS_RS08565	COG0628	permease
CLOS_RS08585	COG1959	2 iron, 2 sulfur cluster binding
CLOS_RS08590	COG2340	Cysteine-rich secretory protein family
CLOS_RS08610	COG0326	Molecular chaperone. Has ATPase activity
CLOS_RS08620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLOS_RS08645	COG1234	tRNA 3'-trailer cleavage
CLOS_RS08670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLOS_RS08695	COG3457	Alanine racemase
CLOS_RS08705	COG5012	cobalamin binding
CLOS_RS08715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLOS_RS08725	COG3804	dihydrodipicolinate reductase
CLOS_RS08730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLOS_RS08750	COG1362	aminopeptidase activity
CLOS_RS08765	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CLOS_RS08775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLOS_RS08780	COG0124	histidyl-tRNA synthetase
CLOS_RS08785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLOS_RS08790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLOS_RS08795	COG1490	D-aminoacyl-tRNA deacylase activity
CLOS_RS08800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLOS_RS08805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLOS_RS08810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLOS_RS08810	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CLOS_RS08830	COG1862	Preprotein translocase
CLOS_RS08845	COG2247	cell wall binding repeat
CLOS_RS08845	COG2385	sporulation resulting in formation of a cellular spore
CLOS_RS08850	COG2255	four-way junction helicase activity
CLOS_RS08855	COG0632	four-way junction helicase activity
CLOS_RS08860	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CLOS_RS08865	COG1067	ATP-dependent peptidase activity
CLOS_RS08880	COG1268	BioY protein
CLOS_RS08885	COG1187	pseudouridine synthase activity
CLOS_RS08895	COG5002	protein histidine kinase activity
CLOS_RS08900	COG0745	RESPONSE REGULATOR receiver
CLOS_RS08910	COG1921	L-seryl-tRNASec selenium transferase activity
CLOS_RS08915	COG1115	amino acid carrier protein
CLOS_RS08920	COG0709	Synthesizes selenophosphate from selenide and ATP
CLOS_RS08925	COG1555	photosystem II stabilization
CLOS_RS08930	COG1686	Belongs to the peptidase S11 family
CLOS_RS08935	COG1760	l-serine dehydratase
CLOS_RS08940	COG1760	l-serine dehydratase
CLOS_RS08945	COG0251	oxidation-reduction process
CLOS_RS08955	COG0799	negative regulation of ribosome biogenesis
CLOS_RS08960	COG1316	TRANSCRIPTIONal
CLOS_RS08965	COG1713	HD superfamily hydrolase involved in NAD metabolism
CLOS_RS08980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLOS_RS08995	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CLOS_RS09025	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CLOS_RS09030	COG2894	cell division
CLOS_RS09035	COG0850	regulation of cytokinetic process
CLOS_RS09040	COG0768	penicillin binding
CLOS_RS09055	COG1077	Cell shape determining protein MreB Mrl
CLOS_RS09060	COG2003	Belongs to the UPF0758 family
CLOS_RS09065	COG0424	maF-like protein
CLOS_RS09080	COG1245	4Fe-4S binding domain
CLOS_RS09080	COG2878	Part of a membrane complex involved in electron transport
CLOS_RS09085	COG4657	Part of a membrane complex involved in electron transport
CLOS_RS09090	COG4660	Part of a membrane complex involved in electron transport
CLOS_RS09095	COG4659	FMN binding
CLOS_RS09100	COG4658	electron transport chain
CLOS_RS09105	COG4656	Part of a membrane complex involved in electron transport
CLOS_RS09115	COG1388	LysM domain
CLOS_RS09115	COG0791	NLP P60 protein
CLOS_RS09120	COG0217	transcriptional regulatory protein
CLOS_RS09125	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLOS_RS09135	COG0730	response to heat
CLOS_RS09145	COG1739	Uncharacterized protein family UPF0029
CLOS_RS09160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLOS_RS09200	COG1191	sigma factor activity
CLOS_RS09205	COG2172	sigma factor antagonist activity
CLOS_RS09215	COG0519	Catalyzes the synthesis of GMP from XMP
CLOS_RS09220	COG1335	isochorismatase
CLOS_RS09255	COG2851	Citrate transporter
CLOS_RS09260	COG3829	transcription factor binding
CLOS_RS09260	COG3290	protein histidine kinase activity
CLOS_RS09270	COG0534	Mate efflux family protein
CLOS_RS09275	COG0456	acetyltransferase
CLOS_RS09285	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLOS_RS09290	COG0315	cyclic pyranopterin monophosphate synthase activity
CLOS_RS09295	COG0301	tRNA thio-modification
CLOS_RS09300	COG1104	cysteine desulfurase activity
CLOS_RS09315	COG0210	DNA helicase
CLOS_RS09390	COG1396	sequence-specific DNA binding
CLOS_RS09515	COG0280	phosphate acetyltransferase
CLOS_RS09530	COG1032	radical SAM domain protein
CLOS_RS09550	COG1683	Conserved Protein
CLOS_RS09555	COG1193	negative regulation of DNA recombination
CLOS_RS09560	COG1217	gtp-binding protein TYPA
CLOS_RS09565	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CLOS_RS09570	COG2081	HI0933 family
CLOS_RS09575	COG1592	Rubrerythrin
CLOS_RS09585	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLOS_RS09590	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLOS_RS09840	COG3541	Predicted nucleotidyltransferase
CLOS_RS09855	COG2801	Transposase and inactivated derivatives
CLOS_RS10010	COG3177	Filamentation induced by cAMP protein fic
CLOS_RS10020	COG1475	DNA binding
CLOS_RS10025	COG1192	Involved in chromosome partitioning
CLOS_RS10040	COG2032	superoxide dismutase activity
CLOS_RS10085	COG0598	Magnesium transport protein CorA
CLOS_RS10090	COG2267	carboxylic ester hydrolase activity
CLOS_RS10095	COG1690	Belongs to the RtcB family
CLOS_RS10100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLOS_RS10105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLOS_RS10120	COG1546	Belongs to the CinA family
CLOS_RS10120	COG1058	Belongs to the CinA family
CLOS_RS10125	COG1388	LysM domain
CLOS_RS10125	COG3942	CHAP domain
CLOS_RS10135	COG1388	LysM domain
CLOS_RS10135	COG3858	chitin binding
CLOS_RS10140	COG1132	(ABC) transporter
CLOS_RS10145	COG1132	(ABC) transporter
CLOS_RS10165	COG0426	domain, Protein
CLOS_RS10170	COG2233	PERMEase
CLOS_RS10185	COG0083	homoserine kinase activity
CLOS_RS10190	COG4492	Belongs to the UPF0735 family
CLOS_RS10210	COG0835	chemotaxis
CLOS_RS10210	COG0784	Response regulator, receiver
CLOS_RS10235	COG3608	succinylglutamate desuccinylase aspartoacylase
CLOS_RS10235	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CLOS_RS10240	COG0534	Mate efflux family protein
CLOS_RS10245	COG1666	GTP binding
CLOS_RS10255	COG0826	peptidase U32
CLOS_RS10265	COG0072	phenylalanine-tRNA ligase activity
CLOS_RS10265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOS_RS10270	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CLOS_RS10275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLOS_RS10280	COG0569	domain protein
CLOS_RS10285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CLOS_RS10290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CLOS_RS10295	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CLOS_RS10300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CLOS_RS10310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLOS_RS10330	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLOS_RS10335	COG3344	reverse transcriptase
CLOS_RS10345	COG0222	ribosome binding
CLOS_RS10350	COG2801	Transposase and inactivated derivatives
CLOS_RS10405	COG5566	PFAM Mor transcription activator
CLOS_RS10420	COG2801	Transposase and inactivated derivatives
CLOS_RS10455	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CLOS_RS10465	COG1278	Cold shock
CLOS_RS10470	COG2226	methyltransferase
CLOS_RS10480	COG2066	Belongs to the glutaminase family
CLOS_RS10485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLOS_RS10490	COG0517	IMP dehydrogenase activity
CLOS_RS10505	COG2339	peptidase activity
CLOS_RS10515	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CLOS_RS10525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLOS_RS10530	COG0726	polysaccharide deacetylase
CLOS_RS10545	COG4175	Glycine betaine
CLOS_RS10545	COG0517	IMP dehydrogenase activity
CLOS_RS10550	COG1510	regulation of RNA biosynthetic process
CLOS_RS10555	COG0436	Aminotransferase
CLOS_RS10560	COG1283	sodium-dependent phosphate transmembrane transporter activity
CLOS_RS10580	COG0285	dihydrofolate synthase activity
CLOS_RS10605	COG1074	ATP-dependent DNA helicase activity
CLOS_RS10610	COG0443	Heat shock 70 kDa protein
CLOS_RS10625	COG0525	valine-tRNA ligase activity
CLOS_RS10630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLOS_RS10640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CLOS_RS10680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLOS_RS10690	COG2608	mercury ion transmembrane transporter activity
CLOS_RS10695	COG3681	Belongs to the UPF0597 family
CLOS_RS10700	COG3829	transcription factor binding
CLOS_RS10715	COG0384	phenazine biosynthesis protein PhzF
CLOS_RS10720	COG1741	Belongs to the pirin family
CLOS_RS10725	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLOS_RS10770	COG2244	polysaccharide biosynthetic process
CLOS_RS10775	COG0488	(ABC) transporter
CLOS_RS10785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CLOS_RS10810	COG2239	Acts as a magnesium transporter
CLOS_RS10815	COG0772	Belongs to the SEDS family
CLOS_RS10820	COG0840	transmembrane signaling receptor activity
CLOS_RS10850	COG0577	efflux transmembrane transporter activity
CLOS_RS10855	COG1136	(ABC) transporter
CLOS_RS10860	COG2205	protein histidine kinase activity
CLOS_RS10865	COG0745	RESPONSE REGULATOR receiver
CLOS_RS10870	COG3872	metal-dependent enzyme
CLOS_RS10885	COG0312	modulator of DNA gyrase
CLOS_RS10910	COG1116	anion transmembrane transporter activity
CLOS_RS10915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLOS_RS10945	COG2208	phosphoserine phosphatase activity
CLOS_RS10945	COG2770	Histidine kinase
CLOS_RS10950	COG1053	succinate dehydrogenase
CLOS_RS10950	COG3976	FMN-binding domain protein
CLOS_RS10960	COG1053	succinate dehydrogenase
CLOS_RS10960	COG3976	FMN-binding domain protein
CLOS_RS10965	COG4939	FMN-binding domain protein
CLOS_RS10970	COG1477	protein flavinylation
CLOS_RS10985	COG4242	Belongs to the peptidase S51 family
CLOS_RS10990	COG0726	polysaccharide deacetylase
CLOS_RS10995	COG1283	sodium-dependent phosphate transmembrane transporter activity
CLOS_RS11015	COG0746	molybdenum cofactor guanylyltransferase activity
CLOS_RS11020	COG2996	Protein conserved in bacteria
CLOS_RS11040	COG1307	EDD domain protein, DegV family
CLOS_RS11050	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLOS_RS11070	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CLOS_RS11070	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLOS_RS11075	COG1013	pyruvate-flavodoxin oxidoreductase activity
CLOS_RS11085	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CLOS_RS11090	COG0840	transmembrane signaling receptor activity
CLOS_RS11110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLOS_RS11120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLOS_RS11125	COG1121	(ABC) transporter
CLOS_RS11130	COG3443	Belongs to the bacterial solute-binding protein 9 family
CLOS_RS11130	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLOS_RS11135	COG0805	protein transport
CLOS_RS11150	COG2414	aldehyde ferredoxin oxidoreductase
CLOS_RS11155	COG0437	4 iron, 4 sulfur cluster binding
CLOS_RS11160	COG3608	succinylglutamate desuccinylase aspartoacylase
CLOS_RS11160	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CLOS_RS11165	COG2414	aldehyde ferredoxin oxidoreductase
CLOS_RS11170	COG0437	4 iron, 4 sulfur cluster binding
CLOS_RS11180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLOS_RS11185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLOS_RS11195	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CLOS_RS11200	COG1924	4 iron, 4 sulfur cluster binding
CLOS_RS11215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLOS_RS11220	COG3706	GGDEF domain
CLOS_RS11235	COG0285	dihydrofolate synthase activity
CLOS_RS11240	COG4608	Belongs to the ABC transporter superfamily
CLOS_RS11245	COG0444	Belongs to the ABC transporter superfamily
CLOS_RS11250	COG0601	transmembrane transport
CLOS_RS11255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOS_RS11260	COG2217	Heavy metal translocating P-type atpase
CLOS_RS11275	COG2205	protein histidine kinase activity
CLOS_RS11280	COG0745	RESPONSE REGULATOR receiver
CLOS_RS11290	COG1773	rubredoxin
CLOS_RS11300	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CLOS_RS11305	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CLOS_RS11310	COG0470	DNA polymerase III
CLOS_RS11310	COG1067	ATP-dependent peptidase activity
CLOS_RS11315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CLOS_RS11320	COG0740	serine-type endopeptidase activity
CLOS_RS11325	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLOS_RS11330	COG1278	Cold shock
CLOS_RS11340	COG0426	domain, Protein
CLOS_RS11350	COG0549	Belongs to the carbamate kinase family
CLOS_RS11360	COG1595	DNA-templated transcription, initiation
CLOS_RS11370	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CLOS_RS11375	COG0460	homoserine dehydrogenase
CLOS_RS11380	COG0540	Belongs to the ATCase OTCase family
CLOS_RS11390	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CLOS_RS11395	COG0167	dihydroorotate dehydrogenase activity
CLOS_RS11400	COG0543	2 iron, 2 sulfur cluster binding
CLOS_RS11405	COG0284	orotidine-5'-phosphate decarboxylase activity
CLOS_RS11410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CLOS_RS11420	COG2323	membrane
CLOS_RS11425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CLOS_RS11440	COG2199	diguanylate cyclase activity
CLOS_RS11440	COG2203	Gaf domain
CLOS_RS11455	COG0700	Nucleoside recognition
CLOS_RS11460	COG2715	membrane protein required for spore maturation
CLOS_RS11465	COG0840	transmembrane signaling receptor activity
CLOS_RS11490	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CLOS_RS11495	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CLOS_RS11500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLOS_RS11515	COG5564	TIM-barrel signal transduction protein
CLOS_RS11530	COG3192	ethanolamine utilization protein
CLOS_RS11535	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLOS_RS11560	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLOS_RS11565	COG0363	glucosamine-6-phosphate deaminase activity
CLOS_RS11620	COG2801	Transposase and inactivated derivatives
CLOS_RS11685	COG3290	protein histidine kinase activity
CLOS_RS11690	COG3279	Response regulator of the LytR AlgR family
CLOS_RS11700	COG3383	formate dehydrogenase (NAD+) activity
CLOS_RS11710	COG1034	ATP synthesis coupled electron transport
CLOS_RS11735	COG0322	excinuclease ABC activity
CLOS_RS11745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CLOS_RS11750	COG0556	nucleotide-excision repair
CLOS_RS11755	COG0793	Belongs to the peptidase S41A family
CLOS_RS11760	COG4942	peptidase
CLOS_RS11765	COG2177	Part of the ABC transporter FtsEX involved in
CLOS_RS11770	COG2884	Cell division ATP-binding protein ftsE
CLOS_RS11775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CLOS_RS11790	COG3958	Transketolase
CLOS_RS11795	COG3959	Transketolase, thiamine diphosphate binding domain
CLOS_RS11800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLOS_RS11805	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CLOS_RS11825	COG2337	Toxic component of a toxin-antitoxin (TA) module
CLOS_RS11835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLOS_RS11840	COG0736	holo-[acyl-carrier-protein] synthase activity
CLOS_RS11870	COG1910	domain protein
CLOS_RS11875	COG3842	ATPase activity
CLOS_RS11880	COG4149	molybdate abc transporter
CLOS_RS11885	COG0725	ABC transporter, periplasmic molybdate-binding protein
CLOS_RS11895	COG2056	Na+-H+ antiporter family
CLOS_RS11900	COG0531	amino acid
CLOS_RS11905	COG0419	ATPase involved in DNA repair
CLOS_RS11910	COG0420	3'-5' exonuclease activity
CLOS_RS11915	COG1074	ATP-dependent DNA helicase activity
CLOS_RS11920	COG1194	a g-specific adenine glycosylase
CLOS_RS11960	COG0488	(ABC) transporter
CLOS_RS11970	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CLOS_RS11980	COG4868	Belongs to the UPF0371 family
CLOS_RS11990	COG0436	Aminotransferase
CLOS_RS11995	COG3314	Sporulation integral membrane protein YlbJ
CLOS_RS12000	COG0371	Dehydrogenase
CLOS_RS12005	COG3976	FMN-binding domain protein
CLOS_RS12005	COG1053	succinate dehydrogenase
CLOS_RS12005	COG0431	NADPH-dependent FMN reductase
CLOS_RS12015	COG1994	Peptidase M50
CLOS_RS12020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLOS_RS12030	COG0697	spore germination
CLOS_RS12040	COG1363	Peptidase, m42
CLOS_RS12060	COG0708	Exodeoxyribonuclease III
CLOS_RS12075	COG2207	Transcriptional regulator
CLOS_RS12075	COG3708	Transcriptional regulator
CLOS_RS12110	COG1429	ligase activity, forming nitrogen-metal bonds
CLOS_RS12115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOS_RS12125	COG1592	Rubrerythrin
CLOS_RS12130	COG0688	phosphatidylethanolamine metabolic process
CLOS_RS12150	COG0710	3-dehydroquinate dehydratase activity
CLOS_RS12155	COG2070	2-Nitropropane dioxygenase
CLOS_RS12170	COG0017	Asparaginyl-tRNA synthetase
CLOS_RS12175	COG0583	DNA-binding transcription factor activity
CLOS_RS12185	COG1301	dicarboxylic acid transport
CLOS_RS12195	COG0726	polysaccharide deacetylase
CLOS_RS12205	COG0242	peptide deformylase activity
CLOS_RS12225	COG1695	Transcriptional regulator
CLOS_RS12230	COG2814	Major facilitator Superfamily
CLOS_RS12240	COG0346	lactoylglutathione lyase activity
CLOS_RS12255	COG0011	TIGRFAM Protein of
CLOS_RS12260	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CLOS_RS12270	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CLOS_RS12275	COG3290	protein histidine kinase activity
CLOS_RS12275	COG3829	transcription factor binding
CLOS_RS12280	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CLOS_RS12285	COG1333	cytochrome c biogenesis protein
CLOS_RS12290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CLOS_RS12305	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
CLOS_RS12315	COG0840	transmembrane signaling receptor activity
CLOS_RS12320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CLOS_RS12325	COG0628	permease
CLOS_RS12330	COG1472	Belongs to the glycosyl hydrolase 3 family
CLOS_RS12340	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CLOS_RS12350	COG1079	Belongs to the binding-protein-dependent transport system permease family
CLOS_RS12355	COG4603	Belongs to the binding-protein-dependent transport system permease family
CLOS_RS12360	COG3845	ABC transporter
CLOS_RS12365	COG1744	ABC transporter substrate-binding protein PnrA-like
CLOS_RS12375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLOS_RS12385	COG0840	transmembrane signaling receptor activity
CLOS_RS12395	COG4869	propanediol catabolic process
CLOS_RS12400	COG1454	alcohol dehydrogenase
CLOS_RS12400	COG1012	belongs to the aldehyde dehydrogenase family
CLOS_RS12405	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CLOS_RS12420	COG4656	Part of a membrane complex involved in electron transport
CLOS_RS12425	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CLOS_RS12450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CLOS_RS12455	COG1882	Formate acetyltransferase
CLOS_RS12460	COG1012	belongs to the aldehyde dehydrogenase family
CLOS_RS12460	COG1454	alcohol dehydrogenase
CLOS_RS12490	COG1454	alcohol dehydrogenase
CLOS_RS12490	COG1012	belongs to the aldehyde dehydrogenase family
CLOS_RS12495	COG3275	phosphorelay sensor kinase activity
CLOS_RS12530	COG3426	butyrate kinase activity
CLOS_RS12535	COG0280	phosphate acetyltransferase
CLOS_RS12540	COG3829	transcription factor binding
CLOS_RS12540	COG3290	protein histidine kinase activity
CLOS_RS12550	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CLOS_RS12555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLOS_RS12555	COG5322	oxidoreductase activity
CLOS_RS12835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CLOS_RS12845	COG2323	membrane
CLOS_RS12850	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CLOS_RS12855	COG4536	flavin adenine dinucleotide binding
CLOS_RS12860	COG1376	ErfK ybiS ycfS ynhG family protein
CLOS_RS12865	COG1120	ATPase activity
CLOS_RS12870	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOS_RS12875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOS_RS12890	COG0671	phosphoesterase, PA-phosphatase related
CLOS_RS12940	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CLOS_RS12945	COG3246	L-lysine catabolic process to acetate
CLOS_RS12950	COG0183	Belongs to the thiolase family
CLOS_RS12955	COG3290	protein histidine kinase activity
CLOS_RS12955	COG3829	transcription factor binding
CLOS_RS12965	COG0459	protein refolding
CLOS_RS12970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLOS_RS13000	COG1131	(ABC) transporter
CLOS_RS13005	COG0167	dihydroorotate dehydrogenase activity
CLOS_RS13015	COG0402	S-adenosylhomocysteine deaminase activity
CLOS_RS13020	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CLOS_RS13035	COG2221	Nitrite and sulphite reductase 4Fe-4S
CLOS_RS13050	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CLOS_RS13055	COG0488	(ABC) transporter
CLOS_RS13060	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLOS_RS13065	COG0456	acetyltransferase
CLOS_RS13070	COG1214	PFAM Peptidase M22, glycoprotease
CLOS_RS13075	COG0802	atpase or kinase
CLOS_RS13085	COG2207	Transcriptional regulator
CLOS_RS13085	COG4753	response regulator
CLOS_RS13090	COG4251	negative regulation of phosphorylation
CLOS_RS13095	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CLOS_RS13105	COG1228	amidohydrolase
CLOS_RS13110	COG2183	response to ionizing radiation
CLOS_RS13125	COG2257	FlhB HrpN YscU SpaS Family
CLOS_RS13140	COG0840	transmembrane signaling receptor activity
CLOS_RS13145	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CLOS_RS13150	COG0653	protein targeting
CLOS_RS13160	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CLOS_RS13170	COG1516	flagellar protein fliS
CLOS_RS13190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLOS_RS13195	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CLOS_RS13200	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CLOS_RS13205	COG3829	transcription factor binding
CLOS_RS13210	COG1757	Na H antiporter
CLOS_RS13220	COG0411	ABC transporter
CLOS_RS13270	COG2089	acid synthase
CLOS_RS13285	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CLOS_RS13290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLOS_RS13295	COG1086	Polysaccharide biosynthesis protein
CLOS_RS13310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLOS_RS13315	COG0840	transmembrane signaling receptor activity
CLOS_RS13330	COG4786	Flagellar basal body rod
CLOS_RS13330	COG1256	bacterial-type flagellum assembly
CLOS_RS13350	COG1040	competence protein
CLOS_RS13355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLOS_RS13375	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CLOS_RS13390	COG3906	Belongs to the UPF0473 family
CLOS_RS13400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLOS_RS13410	COG1177	transmembrane transport
CLOS_RS13415	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLOS_RS13420	COG3842	ATPase activity
CLOS_RS13430	COG1285	pathogenesis
CLOS_RS13435	COG2610	gluconate transmembrane transporter activity
CLOS_RS13445	COG3395	kinase activity
CLOS_RS13450	COG1349	DNA-binding transcription factor activity
CLOS_RS13455	COG3942	CHAP domain
CLOS_RS13455	COG1388	LysM domain
CLOS_RS13470	COG4786	Flagellar basal body rod
CLOS_RS13480	COG1609	Transcriptional regulator
CLOS_RS13490	COG2385	sporulation resulting in formation of a cellular spore
CLOS_RS13495	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLOS_RS13515	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CLOS_RS13520	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLOS_RS13525	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLOS_RS13530	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLOS_RS13535	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLOS_RS13540	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CLOS_RS13545	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLOS_RS13565	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLOS_RS13570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLOS_RS13575	COG2131	deaminase
CLOS_RS13580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CLOS_RS13585	COG0698	ribose 5-phosphate isomerase
CLOS_RS13590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLOS_RS13595	COG0009	L-threonylcarbamoyladenylate synthase
CLOS_RS13600	COG0768	penicillin binding
CLOS_RS13610	COG1716	ATPase activity
CLOS_RS13615	COG0428	transporter
CLOS_RS13620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CLOS_RS13625	COG2890	protein-(glutamine-N5) methyltransferase activity
CLOS_RS13630	COG3872	metal-dependent enzyme
CLOS_RS13635	COG0842	Transport permease protein
CLOS_RS13645	COG1131	(ABC) transporter
CLOS_RS13655	COG0495	leucyl-tRNA aminoacylation
CLOS_RS13665	COG1435	thymidine kinase activity
CLOS_RS13670	COG0254	rRNA binding
CLOS_RS13675	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLOS_RS13680	COG1126	abc transporter atp-binding protein
CLOS_RS13685	COG0765	amino acid transport
CLOS_RS13690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOS_RS13695	COG1494	fructose-1,6-bisphosphatase
CLOS_RS13700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CLOS_RS13705	COG3246	L-lysine catabolic process to acetate
CLOS_RS13710	COG1607	acyl-coa hydrolase
CLOS_RS13715	COG0733	neurotransmitter:sodium symporter activity
CLOS_RS13720	COG0733	neurotransmitter:sodium symporter activity
CLOS_RS13725	COG1361	Conserved repeat domain
CLOS_RS13730	COG2373	Large extracellular alpha-helical protein
CLOS_RS13765	COG0840	transmembrane signaling receptor activity
CLOS_RS13790	COG0577	efflux transmembrane transporter activity
CLOS_RS13790	COG1136	(ABC) transporter
CLOS_RS13800	COG1136	(ABC) transporter
CLOS_RS13815	COG1136	(ABC) transporter
CLOS_RS13835	COG4974	Belongs to the 'phage' integrase family
CLOS_RS13845	COG3328	transposase activity
CLOS_RS13860	COG2373	Large extracellular alpha-helical protein
CLOS_RS13865	COG2208	phosphoserine phosphatase activity
CLOS_RS13870	COG0248	Ppx GppA phosphatase
CLOS_RS13875	COG1098	S1 RNA binding domain
CLOS_RS13895	COG2385	sporulation resulting in formation of a cellular spore
CLOS_RS13900	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CLOS_RS13905	COG0776	regulation of translation
CLOS_RS13910	COG3956	TIGRFAM MazG family protein
CLOS_RS13915	COG2244	polysaccharide biosynthetic process
CLOS_RS13920	COG2002	toxin-antitoxin pair type II binding
CLOS_RS13930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLOS_RS13940	COG0193	aminoacyl-tRNA hydrolase activity
CLOS_RS13950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLOS_RS13955	COG2088	sporulation resulting in formation of a cellular spore
CLOS_RS13960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLOS_RS13965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLOS_RS13970	COG1316	TRANSCRIPTIONal
CLOS_RS13975	COG1305	Transglutaminase-like
CLOS_RS13985	COG0714	Associated with various cellular activities
CLOS_RS13990	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOS_RS13995	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CLOS_RS14005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLOS_RS14010	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CLOS_RS14015	COG3584	3D domain protein
CLOS_RS14015	COG3583	domain protein
CLOS_RS14025	COG0084	hydrolase, TatD family'
CLOS_RS14030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOS_RS14030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOS_RS14040	COG0700	Nucleoside recognition
CLOS_RS14045	COG2715	membrane protein required for spore maturation
CLOS_RS14050	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLOS_RS14055	COG2002	toxin-antitoxin pair type II binding
CLOS_RS14060	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CLOS_RS14065	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CLOS_RS14085	COG1191	sigma factor activity
CLOS_RS14090	COG1757	Na H antiporter
CLOS_RS14105	COG1132	(ABC) transporter
CLOS_RS14120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CLOS_RS14125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLOS_RS14130	COG0765	amino acid transport
CLOS_RS14145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOS_RS14160	COG1882	Formate acetyltransferase
CLOS_RS14165	COG1802	Transcriptional regulator
CLOS_RS14170	COG0431	NADPH-dependent FMN reductase
CLOS_RS14170	COG1053	succinate dehydrogenase
CLOS_RS14170	COG3976	FMN-binding domain protein
CLOS_RS14185	COG0352	thiamine-phosphate diphosphorylase activity
CLOS_RS14190	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CLOS_RS14195	COG0351	phosphomethylpyrimidine kinase
CLOS_RS14200	COG1028	Short-chain dehydrogenase reductase Sdr
CLOS_RS14210	COG1114	Component of the transport system for branched-chain amino acids
CLOS_RS14215	COG1193	negative regulation of DNA recombination
CLOS_RS14220	COG2205	protein histidine kinase activity
CLOS_RS14235	COG4120	Belongs to the binding-protein-dependent transport system permease family
CLOS_RS14250	COG0697	spore germination
CLOS_RS14260	COG1489	DNA binding
CLOS_RS14265	COG1671	Belongs to the UPF0178 family
CLOS_RS14270	COG1053	succinate dehydrogenase
CLOS_RS14275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLOS_RS14280	COG0039	L-malate dehydrogenase activity
CLOS_RS14300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLOS_RS14305	COG0785	Cytochrome C biogenesis protein
CLOS_RS14310	COG0697	spore germination
CLOS_RS14345	COG2832	Protein of unknown function (DUF454)
CLOS_RS14365	COG0519	Catalyzes the synthesis of GMP from XMP
CLOS_RS14370	COG0456	acetyltransferase
CLOS_RS14375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLOS_RS14385	COG1522	sequence-specific DNA binding
CLOS_RS14390	COG3844	kynureninase activity
CLOS_RS14395	COG2824	Alkylphosphonate utilization operon protein PhnA
CLOS_RS14410	COG0346	lactoylglutathione lyase activity
CLOS_RS14420	COG1757	Na H antiporter
CLOS_RS14425	COG0018	arginyl-trna synthetase
CLOS_RS14430	COG1011	Hydrolase
CLOS_RS14435	COG1115	amino acid carrier protein
CLOS_RS14440	COG0024	Methionine aminopeptidase
CLOS_RS14450	COG3708	Transcriptional regulator
CLOS_RS14450	COG2207	Transcriptional regulator
CLOS_RS14460	COG0697	spore germination
CLOS_RS14465	COG2207	Transcriptional regulator
CLOS_RS14470	COG0778	Nitroreductase
CLOS_RS14480	COG1131	(ABC) transporter
CLOS_RS14520	COG1307	EDD domain protein, DegV family
CLOS_RS14535	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CLOS_RS14540	COG1357	PFAM Pentapeptide repeats (8 copies)
CLOS_RS14555	COG2226	methyltransferase
CLOS_RS14585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CLOS_RS14605	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CLOS_RS14610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLOS_RS14615	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CLOS_RS14640	COG5002	protein histidine kinase activity
CLOS_RS14645	COG0745	RESPONSE REGULATOR receiver
CLOS_RS14655	COG1404	Belongs to the peptidase S8 family
CLOS_RS14660	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CLOS_RS14665	COG3706	GGDEF domain
CLOS_RS14675	COG3279	Response regulator of the LytR AlgR family
CLOS_RS14680	COG0745	RESPONSE REGULATOR receiver
CLOS_RS14680	COG2972	Histidine kinase
CLOS_RS14685	COG4942	peptidase
CLOS_RS14710	COG0305	Participates in initiation and elongation during chromosome replication
CLOS_RS14715	COG0359	binds to the 23S rRNA
CLOS_RS14720	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CLOS_RS14745	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CLOS_RS14750	COG2703	oxygen carrier activity
CLOS_RS14755	COG1592	Rubrerythrin
CLOS_RS14765	COG0484	heat shock protein binding
CLOS_RS14775	COG2819	hydrolase of the alpha beta superfamily
CLOS_RS14780	COG1120	ATPase activity
CLOS_RS14785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOS_RS14790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOS_RS14795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLOS_RS14810	COG0726	polysaccharide deacetylase
CLOS_RS14845	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLOS_RS14860	COG4191	Histidine kinase
CLOS_RS14915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLOS_RS14935	COG0494	nUDIX hydrolase
CLOS_RS14955	COG0456	acetyltransferase
CLOS_RS14970	COG2207	Transcriptional regulator
CLOS_RS14970	COG3708	Transcriptional regulator
CLOS_RS15010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CLOS_RS15015	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CLOS_RS15020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLOS_RS15040	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLOS_RS15045	COG2720	vancomycin resistance protein
CLOS_RS15060	COG1597	lipid kinase activity
CLOS_RS15070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLOS_RS15075	COG1475	DNA binding
CLOS_RS15080	COG1192	Involved in chromosome partitioning
CLOS_RS15090	COG0357	Ribosomal RNA small subunit methyltransferase G
CLOS_RS15095	COG0445	tRNA wobble uridine modification
CLOS_RS15100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLOS_RS15105	COG1847	R3H domain protein
CLOS_RS15110	COG0706	membrane insertase activity
CLOS_RS15115	COG0594	ribonuclease P activity
CLOS_RS15120	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CLOS_RS15155	COG3976	FMN-binding domain protein
CLOS_RS15155	COG1053	succinate dehydrogenase
CLOS_RS15160	COG2340	Cysteine-rich secretory protein family
CLOS_RS15190	COG2770	Histidine kinase
CLOS_RS15190	COG2205	protein histidine kinase activity
CLOS_RS15195	COG3706	GGDEF domain
CLOS_RS15215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLOS_RS15220	COG3706	GGDEF domain
CLOS_RS15230	COG3773	Cell wall hydrolase
CLOS_RS15235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLOS_RS15245	COG1399	metal-binding, possibly nucleic acid-binding protein
CLOS_RS15260	COG1994	Peptidase M50
CLOS_RS15275	COG3620	sequence-specific DNA binding
CLOS_RS15305	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CLOS_RS15320	COG3437	response regulator, receiver
CLOS_RS15330	COG2199	diguanylate cyclase activity
CLOS_RS15330	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLOS_RS15350	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CLOS_RS15360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLOS_RS15380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLOS_RS15385	COG0789	Transcriptional regulator
CLOS_RS15390	COG0456	acetyltransferase
CLOS_RS15390	COG0454	-acetyltransferase
CLOS_RS15395	COG0596	Alpha beta hydrolase
CLOS_RS15395	COG0508	dehydrogenase complex catalyzes the overall conversion of