locus-tag	class	description
HYG84_RS00005	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HYG84_RS00015	COG2508	Transcriptional regulator
HYG84_RS00020	COG2233	PERMEase
HYG84_RS00040	COG0534	Mate efflux family protein
HYG84_RS00050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYG84_RS00055	COG1309	transcriptional regulator
HYG84_RS00060	COG1214	PFAM Peptidase M22, glycoprotease
HYG84_RS00060	COG0456	acetyltransferase
HYG84_RS00070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYG84_RS00080	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HYG84_RS00090	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HYG84_RS00095	COG5012	cobalamin binding
HYG84_RS00105	COG0484	heat shock protein binding
HYG84_RS00120	COG2205	protein histidine kinase activity
HYG84_RS00125	COG0745	RESPONSE REGULATOR receiver
HYG84_RS00135	COG1136	(ABC) transporter
HYG84_RS00150	COG1982	Orn Lys Arg decarboxylase major
HYG84_RS00160	COG2720	vancomycin resistance protein
HYG84_RS00175	COG3192	ethanolamine utilization protein
HYG84_RS00180	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HYG84_RS00190	COG4869	propanediol catabolic process
HYG84_RS00205	COG1454	alcohol dehydrogenase
HYG84_RS00205	COG1012	belongs to the aldehyde dehydrogenase family
HYG84_RS00225	COG4303	Ethanolamine ammonia lyase large subunit
HYG84_RS00245	COG2096	Adenosyltransferase
HYG84_RS00250	COG4917	ethanolamine utilization protein
HYG84_RS00290	COG1595	DNA-templated transcription, initiation
HYG84_RS00295	COG0384	phenazine biosynthesis protein PhzF
HYG84_RS00335	COG2323	membrane
HYG84_RS00355	COG1187	pseudouridine synthase activity
HYG84_RS00360	COG1183	phosphatidylcholine synthase activity
HYG84_RS00365	COG0191	fructose-bisphosphate aldolase activity
HYG84_RS00375	COG2357	RelA SpoT domain protein
HYG84_RS00395	COG1242	4 iron, 4 sulfur cluster binding
HYG84_RS00415	COG1131	(ABC) transporter
HYG84_RS00420	COG1309	transcriptional regulator
HYG84_RS00425	COG3693	PFAM glycoside hydrolase, family 10
HYG84_RS00445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYG84_RS00455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYG84_RS00465	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HYG84_RS00485	COG1725	Transcriptional regulator
HYG84_RS00500	COG2310	stress, protein
HYG84_RS00505	COG2310	stress, protein
HYG84_RS00520	COG3853	Toxic anion resistance protein (TelA)
HYG84_RS00540	COG1595	DNA-templated transcription, initiation
HYG84_RS00545	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HYG84_RS00560	COG1979	alcohol dehydrogenase
HYG84_RS00575	COG3973	AAA domain
HYG84_RS00580	COG0564	pseudouridine synthase activity
HYG84_RS00585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HYG84_RS00585	COG0116	Belongs to the methyltransferase superfamily
HYG84_RS00605	COG1649	PFAM Uncharacterised BCR, COG1649
HYG84_RS00610	COG1132	(ABC) transporter
HYG84_RS00615	COG1132	(ABC) transporter
HYG84_RS00625	COG2207	Transcriptional regulator
HYG84_RS00630	COG1876	peptidase activity
HYG84_RS00635	COG1773	rubredoxin
HYG84_RS00640	COG2364	Membrane
HYG84_RS00670	COG2358	TRAP transporter, solute receptor (TAXI family
HYG84_RS00680	COG3263	regulation of cellular component size
HYG84_RS00695	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HYG84_RS00700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HYG84_RS00730	COG0596	Alpha beta hydrolase
HYG84_RS00735	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYG84_RS00740	COG2086	electron transfer activity
HYG84_RS00745	COG1960	acyl-CoA dehydrogenase activity
HYG84_RS00755	COG0569	domain protein
HYG84_RS00760	COG0488	(ABC) transporter
HYG84_RS00765	COG1690	Belongs to the RtcB family
HYG84_RS00770	COG4536	flavin adenine dinucleotide binding
HYG84_RS00775	COG0351	phosphomethylpyrimidine kinase
HYG84_RS00775	COG0352	thiamine-phosphate diphosphorylase activity
HYG84_RS00780	COG1671	Belongs to the UPF0178 family
HYG84_RS00785	COG0789	Transcriptional regulator
HYG84_RS00795	COG1132	(ABC) transporter
HYG84_RS00815	COG1215	transferase activity, transferring glycosyl groups
HYG84_RS00820	COG0463	Glycosyl transferase, family 2
HYG84_RS00825	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYG84_RS00835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYG84_RS00840	COG0546	phosphoglycolate phosphatase activity
HYG84_RS00845	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HYG84_RS00860	COG1164	Oligoendopeptidase f
HYG84_RS00875	COG1757	Na H antiporter
HYG84_RS00880	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYG84_RS00895	COG0492	ferredoxin-NADP+ reductase activity
HYG84_RS00900	COG3118	belongs to the thioredoxin family
HYG84_RS00915	COG1136	(ABC) transporter
HYG84_RS00920	COG1136	(ABC) transporter
HYG84_RS00920	COG0577	efflux transmembrane transporter activity
HYG84_RS00925	COG0745	RESPONSE REGULATOR receiver
HYG84_RS00930	COG5002	protein histidine kinase activity
HYG84_RS00945	COG2233	PERMEase
HYG84_RS00970	COG1595	DNA-templated transcription, initiation
HYG84_RS00975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HYG84_RS00985	COG1131	(ABC) transporter
HYG84_RS01005	COG1131	(ABC) transporter
HYG84_RS01020	COG0531	amino acid
HYG84_RS01025	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HYG84_RS01035	COG1595	DNA-templated transcription, initiation
HYG84_RS01055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HYG84_RS01060	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HYG84_RS01065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYG84_RS01075	COG1316	TRANSCRIPTIONal
HYG84_RS01085	COG0662	Cupin 2, conserved barrel domain protein
HYG84_RS01115	COG2304	oxidoreductase activity
HYG84_RS01125	COG0714	Associated with various cellular activities
HYG84_RS01130	COG4716	Myosin-crossreactive antigen
HYG84_RS01190	COG4978	Transcriptional regulator
HYG84_RS01190	COG0789	Transcriptional regulator
HYG84_RS01210	COG0488	(ABC) transporter
HYG84_RS01230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HYG84_RS01260	COG5002	protein histidine kinase activity
HYG84_RS01265	COG0745	RESPONSE REGULATOR receiver
HYG84_RS01310	COG5566	PFAM Mor transcription activator
HYG84_RS01335	COG1131	(ABC) transporter
HYG84_RS01445	COG4974	Belongs to the 'phage' integrase family
HYG84_RS01470	COG0824	Thioesterase
HYG84_RS01480	COG0205	6-phosphofructokinase activity
HYG84_RS01490	COG0587	DNA-directed DNA polymerase activity
HYG84_RS01505	COG1136	(ABC) transporter
HYG84_RS01520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HYG84_RS01525	COG1481	regulation of sporulation
HYG84_RS01535	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HYG84_RS01540	COG1660	Displays ATPase and GTPase activities
HYG84_RS01545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYG84_RS01555	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYG84_RS01575	COG0322	excinuclease ABC activity
HYG84_RS01585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYG84_RS01590	COG0556	nucleotide-excision repair
HYG84_RS01600	COG0793	Belongs to the peptidase S41A family
HYG84_RS01605	COG0739	heme binding
HYG84_RS01610	COG2177	Part of the ABC transporter FtsEX involved in
HYG84_RS01615	COG2884	Cell division ATP-binding protein ftsE
HYG84_RS01620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYG84_RS01625	COG3394	polysaccharide catabolic process
HYG84_RS01630	COG1486	melibiose metabolic process
HYG84_RS01635	COG1447	Phosphotransferase system cellobiose-specific component IIA
HYG84_RS01640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG84_RS01650	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HYG84_RS01650	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HYG84_RS01665	COG3958	Transketolase
HYG84_RS01670	COG3959	Transketolase, thiamine diphosphate binding domain
HYG84_RS01675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYG84_RS01700	COG2337	Toxic component of a toxin-antitoxin (TA) module
HYG84_RS01720	COG0736	holo-[acyl-carrier-protein] synthase activity
HYG84_RS01735	COG4608	Belongs to the ABC transporter superfamily
HYG84_RS01740	COG0444	Belongs to the ABC transporter superfamily
HYG84_RS01745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG84_RS01750	COG0601	transmembrane transport
HYG84_RS01755	COG4166	transmembrane transport
HYG84_RS01765	COG1132	(ABC) transporter
HYG84_RS01770	COG0747	negative chemotaxis
HYG84_RS01775	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HYG84_RS01825	COG0745	RESPONSE REGULATOR receiver
HYG84_RS01830	COG2205	protein histidine kinase activity
HYG84_RS01850	COG3344	reverse transcriptase
HYG84_RS01855	COG0747	negative chemotaxis
HYG84_RS01860	COG0384	phenazine biosynthesis protein PhzF
HYG84_RS01870	COG0726	polysaccharide deacetylase
HYG84_RS01875	COG0419	ATPase involved in DNA repair
HYG84_RS01880	COG0420	3'-5' exonuclease activity
HYG84_RS01885	COG1074	ATP-dependent DNA helicase activity
HYG84_RS01890	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HYG84_RS01910	COG1132	(ABC) transporter
HYG84_RS01915	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYG84_RS01940	COG0642	Histidine kinase
HYG84_RS01945	COG0745	RESPONSE REGULATOR receiver
HYG84_RS01965	COG4868	Belongs to the UPF0371 family
HYG84_RS01975	COG1994	Peptidase M50
HYG84_RS01980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYG84_RS01990	COG1363	Peptidase, m42
HYG84_RS02000	COG0708	Exodeoxyribonuclease III
HYG84_RS02005	COG1533	DNA photolyase activity
HYG84_RS02010	COG2207	Transcriptional regulator
HYG84_RS02010	COG3708	Transcriptional regulator
HYG84_RS02015	COG2226	methyltransferase
HYG84_RS02045	COG1846	Transcriptional regulator
HYG84_RS02050	COG0604	alcohol dehydrogenase
HYG84_RS02060	COG1794	racemase activity, acting on amino acids and derivatives
HYG84_RS02070	COG3829	transcription factor binding
HYG84_RS02075	COG5002	protein histidine kinase activity
HYG84_RS02080	COG0745	RESPONSE REGULATOR receiver
HYG84_RS02115	COG1592	Rubrerythrin
HYG84_RS02120	COG0363	glucosamine-6-phosphate deaminase activity
HYG84_RS02130	COG1737	Transcriptional regulator
HYG84_RS02140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYG84_RS02140	COG1263	PTS System
HYG84_RS02150	COG0688	phosphatidylethanolamine metabolic process
HYG84_RS02160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HYG84_RS02165	COG0167	dihydroorotate dehydrogenase activity
HYG84_RS02170	COG0543	2 iron, 2 sulfur cluster binding
HYG84_RS02175	COG0284	orotidine-5'-phosphate decarboxylase activity
HYG84_RS02180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYG84_RS02190	COG1408	metallophosphoesterase
HYG84_RS02200	COG2070	2-Nitropropane dioxygenase
HYG84_RS02225	COG2274	protein secretion by the type I secretion system
HYG84_RS02230	COG0017	Asparaginyl-tRNA synthetase
HYG84_RS02240	COG0726	polysaccharide deacetylase
HYG84_RS02245	COG2508	Transcriptional regulator
HYG84_RS02250	COG0549	Belongs to the carbamate kinase family
HYG84_RS02255	COG1301	dicarboxylic acid transport
HYG84_RS02265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HYG84_RS02270	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HYG84_RS02275	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HYG84_RS02280	COG3257	ureidoglycine aminohydrolase activity
HYG84_RS02285	COG2271	Major facilitator Superfamily
HYG84_RS02290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYG84_RS02305	COG0534	Mate efflux family protein
HYG84_RS02310	COG0772	Belongs to the SEDS family
HYG84_RS02315	COG1695	Transcriptional regulator
HYG84_RS02330	COG2814	Major facilitator Superfamily
HYG84_RS02350	COG1704	LemA family
HYG84_RS02365	COG1595	DNA-templated transcription, initiation
HYG84_RS02370	COG0011	TIGRFAM Protein of
HYG84_RS02385	COG1131	(ABC) transporter
HYG84_RS02390	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HYG84_RS02400	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HYG84_RS02405	COG3829	transcription factor binding
HYG84_RS02405	COG3290	protein histidine kinase activity
HYG84_RS02415	COG1333	cytochrome c biogenesis protein
HYG84_RS02425	COG0577	efflux transmembrane transporter activity
HYG84_RS02430	COG1136	(ABC) transporter
HYG84_RS02435	COG5002	protein histidine kinase activity
HYG84_RS02440	COG0745	RESPONSE REGULATOR receiver
HYG84_RS02460	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HYG84_RS02465	COG2056	Na+-H+ antiporter family
HYG84_RS02470	COG1472	Belongs to the glycosyl hydrolase 3 family
HYG84_RS02475	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HYG84_RS02485	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYG84_RS02490	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYG84_RS02495	COG3845	ABC transporter
HYG84_RS02500	COG1744	ABC transporter substrate-binding protein PnrA-like
HYG84_RS02515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYG84_RS02530	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYG84_RS02545	COG3426	butyrate kinase activity
HYG84_RS02550	COG0280	phosphate acetyltransferase
HYG84_RS02555	COG3829	transcription factor binding
HYG84_RS02555	COG3290	protein histidine kinase activity
HYG84_RS02565	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HYG84_RS02575	COG5322	oxidoreductase activity
HYG84_RS02575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYG84_RS02860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HYG84_RS02870	COG2323	membrane
HYG84_RS02875	COG1968	undecaprenyl-diphosphatase activity
HYG84_RS02880	COG4536	flavin adenine dinucleotide binding
HYG84_RS02885	COG1376	ErfK ybiS ycfS ynhG family protein
HYG84_RS02900	COG4149	molybdate abc transporter
HYG84_RS02905	COG0725	ABC transporter, periplasmic molybdate-binding protein
HYG84_RS02920	COG3409	Peptidoglycan-binding domain 1 protein
HYG84_RS02920	COG5632	N-Acetylmuramoyl-L-alanine amidase
HYG84_RS02950	COG3299	homolog of phage Mu protein gp47
HYG84_RS02970	COG2823	Periplasmic or secreted lipoprotein
HYG84_RS02970	COG1652	LysM domain
HYG84_RS03015	COG1396	sequence-specific DNA binding
HYG84_RS03015	COG1917	Cupin 2, conserved barrel domain protein
HYG84_RS03070	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HYG84_RS03080	COG3645	SOS response
HYG84_RS03095	COG4974	Belongs to the 'phage' integrase family
HYG84_RS03100	COG0459	protein refolding
HYG84_RS03105	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HYG84_RS03110	COG1811	Na channel or pump
HYG84_RS03140	COG1131	(ABC) transporter
HYG84_RS03145	COG1346	cytolysis
HYG84_RS03165	COG2221	Nitrite and sulphite reductase 4Fe-4S
HYG84_RS03180	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HYG84_RS03185	COG0488	(ABC) transporter
HYG84_RS03190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HYG84_RS03200	COG0456	acetyltransferase
HYG84_RS03205	COG1214	PFAM Peptidase M22, glycoprotease
HYG84_RS03210	COG0802	atpase or kinase
HYG84_RS03215	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HYG84_RS03230	COG2183	response to ionizing radiation
HYG84_RS03240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG84_RS03260	COG0840	transmembrane signaling receptor activity
HYG84_RS03270	COG0653	protein targeting
HYG84_RS03280	COG2199	diguanylate cyclase activity
HYG84_RS03280	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYG84_RS03290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HYG84_RS03300	COG1516	flagellar protein fliS
HYG84_RS03305	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HYG84_RS03320	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYG84_RS03325	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HYG84_RS03330	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HYG84_RS03335	COG3829	transcription factor binding
HYG84_RS03340	COG1757	Na H antiporter
HYG84_RS03360	COG1592	Rubrerythrin
HYG84_RS03360	COG1773	rubredoxin
HYG84_RS03370	COG0346	lactoylglutathione lyase activity
HYG84_RS03400	COG0457	Tetratricopeptide repeat
HYG84_RS03400	COG0463	Glycosyl transferase, family 2
HYG84_RS03405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG84_RS03415	COG1256	bacterial-type flagellum assembly
HYG84_RS03415	COG4786	Flagellar basal body rod
HYG84_RS03435	COG1040	competence protein
HYG84_RS03440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYG84_RS03465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYG84_RS03510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYG84_RS03520	COG0671	phosphoesterase, PA-phosphatase related
HYG84_RS03525	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HYG84_RS03530	COG1177	transmembrane transport
HYG84_RS03535	COG1176	ABC-type spermidine putrescine transport system, permease component I
HYG84_RS03540	COG3842	ATPase activity
HYG84_RS03545	COG5577	PFAM Coat F domain
HYG84_RS03550	COG0281	malic enzyme
HYG84_RS03555	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HYG84_RS03560	COG1486	melibiose metabolic process
HYG84_RS03565	COG1737	Transcriptional regulator
HYG84_RS03570	COG1263	PTS System
HYG84_RS03570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYG84_RS03585	COG2610	gluconate transmembrane transporter activity
HYG84_RS03590	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HYG84_RS03595	COG3395	kinase activity
HYG84_RS03600	COG1349	DNA-binding transcription factor activity
HYG84_RS03605	COG1376	ErfK ybiS ycfS ynhG family protein
HYG84_RS03615	COG1705	Flagellar rod assembly protein muramidase FlgJ
HYG84_RS03615	COG3951	Flagellar rod assembly protein muramidase FlgJ
HYG84_RS03635	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HYG84_RS03680	COG0438	transferase activity, transferring glycosyl groups
HYG84_RS03690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HYG84_RS03695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HYG84_RS03705	COG3693	PFAM glycoside hydrolase, family 10
HYG84_RS03710	COG3693	PFAM glycoside hydrolase, family 10
HYG84_RS03715	COG4464	protein tyrosine phosphatase activity
HYG84_RS03720	COG0489	protein tyrosine kinase activity
HYG84_RS03725	COG3944	biosynthesis protein
HYG84_RS03740	COG4786	Flagellar basal body rod
HYG84_RS03745	COG1077	Cell shape determining protein MreB Mrl
HYG84_RS03750	COG1609	Transcriptional regulator
HYG84_RS03760	COG2385	sporulation resulting in formation of a cellular spore
HYG84_RS03765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYG84_RS03785	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HYG84_RS03790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HYG84_RS03795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HYG84_RS03800	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HYG84_RS03805	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYG84_RS03810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HYG84_RS03815	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYG84_RS03835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HYG84_RS03840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYG84_RS03845	COG2131	deaminase
HYG84_RS03850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HYG84_RS03855	COG0698	ribose 5-phosphate isomerase
HYG84_RS03860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYG84_RS03865	COG4608	Belongs to the ABC transporter superfamily
HYG84_RS03870	COG0444	Belongs to the ABC transporter superfamily
HYG84_RS03875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG84_RS03880	COG0601	transmembrane transport
HYG84_RS03885	COG0747	negative chemotaxis
HYG84_RS03890	COG2362	D-Aminopeptidase
HYG84_RS03895	COG0009	L-threonylcarbamoyladenylate synthase
HYG84_RS03900	COG0768	penicillin binding
HYG84_RS03915	COG0428	transporter
HYG84_RS03920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HYG84_RS03925	COG2890	protein-(glutamine-N5) methyltransferase activity
HYG84_RS03930	COG3872	metal-dependent enzyme
HYG84_RS03935	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HYG84_RS03950	COG1131	(ABC) transporter
HYG84_RS03960	COG2197	response regulator
HYG84_RS03965	COG4585	Histidine kinase
HYG84_RS03970	COG0495	leucyl-tRNA aminoacylation
HYG84_RS03975	COG1435	thymidine kinase activity
HYG84_RS03980	COG0254	rRNA binding
HYG84_RS03985	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HYG84_RS03990	COG1126	abc transporter atp-binding protein
HYG84_RS03995	COG0765	amino acid transport
HYG84_RS04000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYG84_RS04005	COG1494	fructose-1,6-bisphosphatase
HYG84_RS04010	COG1494	fructose-1,6-bisphosphatase
HYG84_RS04020	COG1122	ATPase activity
HYG84_RS04035	COG0310	cobalt ion transport
HYG84_RS04040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYG84_RS04045	COG3246	L-lysine catabolic process to acetate
HYG84_RS04050	COG1607	acyl-coa hydrolase
HYG84_RS04055	COG0733	neurotransmitter:sodium symporter activity
HYG84_RS04060	COG0733	neurotransmitter:sodium symporter activity
HYG84_RS04065	COG1361	Conserved repeat domain
HYG84_RS04070	COG2373	Large extracellular alpha-helical protein
HYG84_RS04095	COG0728	peptidoglycan biosynthetic process
HYG84_RS04100	COG1368	sulfuric ester hydrolase activity
HYG84_RS04105	COG1032	radical SAM domain protein
HYG84_RS04110	COG1309	transcriptional regulator
HYG84_RS04120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYG84_RS04125	COG0577	efflux transmembrane transporter activity
HYG84_RS04125	COG1136	(ABC) transporter
HYG84_RS04135	COG1136	(ABC) transporter
HYG84_RS04145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYG84_RS04160	COG1309	transcriptional regulator
HYG84_RS04185	COG2373	Large extracellular alpha-helical protein
HYG84_RS04190	COG2208	phosphoserine phosphatase activity
HYG84_RS04200	COG1098	S1 RNA binding domain
HYG84_RS04220	COG2385	sporulation resulting in formation of a cellular spore
HYG84_RS04225	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HYG84_RS04230	COG0776	regulation of translation
HYG84_RS04235	COG3956	TIGRFAM MazG family protein
HYG84_RS04240	COG2244	polysaccharide biosynthetic process
HYG84_RS04245	COG2002	toxin-antitoxin pair type II binding
HYG84_RS04250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYG84_RS04255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HYG84_RS04265	COG0193	aminoacyl-tRNA hydrolase activity
HYG84_RS04275	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HYG84_RS04280	COG2088	sporulation resulting in formation of a cellular spore
HYG84_RS04285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYG84_RS04290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HYG84_RS04300	COG1982	Orn Lys Arg decarboxylase major
HYG84_RS04305	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYG84_RS04310	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HYG84_RS04320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HYG84_RS04325	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HYG84_RS04330	COG3583	domain protein
HYG84_RS04330	COG3584	3D domain protein
HYG84_RS04345	COG1131	(ABC) transporter
HYG84_RS04350	COG1725	Transcriptional regulator
HYG84_RS04360	COG0084	hydrolase, TatD family'
HYG84_RS04365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG84_RS04365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG84_RS04375	COG0700	Nucleoside recognition
HYG84_RS04380	COG2715	membrane protein required for spore maturation
HYG84_RS04385	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HYG84_RS04390	COG2002	toxin-antitoxin pair type II binding
HYG84_RS04395	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HYG84_RS04400	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HYG84_RS04410	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HYG84_RS04415	COG1191	sigma factor activity
HYG84_RS04425	COG1757	Na H antiporter
HYG84_RS04435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYG84_RS04455	COG1132	(ABC) transporter
HYG84_RS04505	COG0352	thiamine-phosphate diphosphorylase activity
HYG84_RS04510	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HYG84_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
HYG84_RS04525	COG1193	negative regulation of DNA recombination
HYG84_RS04530	COG5002	protein histidine kinase activity
HYG84_RS04540	COG0733	neurotransmitter:sodium symporter activity
HYG84_RS04555	COG0697	spore germination
HYG84_RS04575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYG84_RS04580	COG0785	Cytochrome C biogenesis protein
HYG84_RS04600	COG1309	transcriptional regulator
HYG84_RS04605	COG1522	sequence-specific DNA binding
HYG84_RS04610	COG3844	kynureninase activity
HYG84_RS04615	COG2378	regulation of single-species biofilm formation
HYG84_RS04630	COG1011	Hydrolase
HYG84_RS04655	COG0697	spore germination
HYG84_RS04660	COG4977	sequence-specific DNA binding
HYG84_RS04665	COG3655	Transcriptional regulator
HYG84_RS04675	COG1396	sequence-specific DNA binding
HYG84_RS04690	COG4566	intracellular signal transduction
HYG84_RS04695	COG0443	Heat shock 70 kDa protein
HYG84_RS04770	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HYG84_RS04780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYG84_RS04785	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HYG84_RS04810	COG5002	protein histidine kinase activity
HYG84_RS04815	COG0745	RESPONSE REGULATOR receiver
HYG84_RS04825	COG1404	Belongs to the peptidase S8 family
HYG84_RS04830	COG0739	heme binding
HYG84_RS04870	COG0305	Participates in initiation and elongation during chromosome replication
HYG84_RS04875	COG0359	binds to the 23S rRNA
HYG84_RS04880	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HYG84_RS04905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HYG84_RS04910	COG2703	oxygen carrier activity
HYG84_RS04915	COG1592	Rubrerythrin
HYG84_RS04925	COG1686	Belongs to the peptidase S11 family
HYG84_RS04945	COG4555	ABC transporter
HYG84_RS04960	COG0840	transmembrane signaling receptor activity
HYG84_RS04965	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYG84_RS04995	COG5001	Diguanylate cyclase
HYG84_RS05005	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYG84_RS05020	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYG84_RS05030	COG3845	ABC transporter
HYG84_RS05035	COG1744	ABC transporter substrate-binding protein PnrA-like
HYG84_RS05045	COG0456	acetyltransferase
HYG84_RS05060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYG84_RS05070	COG0280	phosphate acetyltransferase
HYG84_RS05075	COG0531	amino acid
HYG84_RS05080	COG1012	belongs to the aldehyde dehydrogenase family
HYG84_RS05085	COG0471	metal ion transport
HYG84_RS05090	COG3829	transcription factor binding
HYG84_RS05090	COG3290	protein histidine kinase activity
HYG84_RS05100	COG0406	alpha-ribazole phosphatase activity
HYG84_RS05105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HYG84_RS05110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HYG84_RS05115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYG84_RS05125	COG3949	Membrane
HYG84_RS05135	COG5002	protein histidine kinase activity
HYG84_RS05150	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYG84_RS05155	COG2720	vancomycin resistance protein
HYG84_RS05165	COG1597	lipid kinase activity
HYG84_RS05180	COG1475	DNA binding
HYG84_RS05185	COG1192	Involved in chromosome partitioning
HYG84_RS05190	COG2119	membrane
HYG84_RS05200	COG0357	Ribosomal RNA small subunit methyltransferase G
HYG84_RS05205	COG0445	tRNA wobble uridine modification
HYG84_RS05210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HYG84_RS05215	COG1847	R3H domain protein
HYG84_RS05220	COG0706	membrane insertase activity
HYG84_RS05225	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HYG84_RS05230	COG0594	ribonuclease P activity
HYG84_RS05235	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HYG84_RS05240	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HYG84_RS05245	COG0592	DNA-directed DNA polymerase activity
HYG84_RS05255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYG84_RS05265	COG0187	DNA topoisomerase II activity
HYG84_RS05270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYG84_RS05280	COG2172	sigma factor antagonist activity
HYG84_RS05285	COG1191	sigma factor activity
HYG84_RS05320	COG1573	uracil-dna glycosylase
HYG84_RS05340	COG0280	phosphate acetyltransferase
HYG84_RS05375	COG0840	transmembrane signaling receptor activity
HYG84_RS05400	COG1827	regulation of RNA biosynthetic process
HYG84_RS05415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HYG84_RS05425	COG0783	Belongs to the Dps family
HYG84_RS05440	COG0840	transmembrane signaling receptor activity
HYG84_RS05470	COG0590	tRNA wobble adenosine to inosine editing
HYG84_RS05485	COG0095	Lipoate-protein ligase
HYG84_RS05500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HYG84_RS05505	COG0022	dehydrogenase e1 component
HYG84_RS05515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HYG84_RS05525	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HYG84_RS05525	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HYG84_RS05530	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYG84_RS05550	COG0425	Belongs to the sulfur carrier protein TusA family
HYG84_RS05560	COG0668	transmembrane transport
HYG84_RS05570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYG84_RS05575	COG3290	protein histidine kinase activity
HYG84_RS05575	COG3829	transcription factor binding
HYG84_RS05585	COG5275	peptidyl-tyrosine sulfation
HYG84_RS05585	COG0252	asparaginase activity
HYG84_RS05600	COG0252	asparaginase activity
HYG84_RS05600	COG5275	peptidyl-tyrosine sulfation
HYG84_RS05605	COG5275	peptidyl-tyrosine sulfation
HYG84_RS05605	COG0252	asparaginase activity
HYG84_RS05620	COG0360	Binds together with S18 to 16S ribosomal RNA
HYG84_RS05630	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYG84_RS05645	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYG84_RS05650	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYG84_RS05670	COG0840	transmembrane signaling receptor activity
HYG84_RS05675	COG1937	Protein conserved in bacteria
HYG84_RS05695	COG3764	Sortase (surface protein transpeptidase)
HYG84_RS05745	COG1357	PFAM Pentapeptide repeats (8 copies)
HYG84_RS05750	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HYG84_RS05770	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HYG84_RS05770	COG4124	Belongs to the glycosyl hydrolase 26 family
HYG84_RS05780	COG1696	Membrane protein involved in D-alanine export
HYG84_RS05785	COG0398	Pfam SNARE associated Golgi protein
HYG84_RS05805	COG1982	Orn Lys Arg decarboxylase major
HYG84_RS05810	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HYG84_RS05815	COG3870	Protein conserved in bacteria
HYG84_RS05825	COG1774	PSP1 C-terminal conserved region
HYG84_RS05830	COG2221	Nitrite and sulphite reductase 4Fe-4S
HYG84_RS05835	COG0493	'glutamate synthase
HYG84_RS05840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HYG84_RS05845	COG0509	glycine decarboxylation via glycine cleavage system
HYG84_RS05850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYG84_RS05855	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYG84_RS05870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HYG84_RS05875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYG84_RS05875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYG84_RS05900	COG3426	butyrate kinase activity
HYG84_RS05905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYG84_RS05915	COG1136	(ABC) transporter
HYG84_RS05920	COG0577	efflux transmembrane transporter activity
HYG84_RS05925	COG5002	protein histidine kinase activity
HYG84_RS05930	COG0745	RESPONSE REGULATOR receiver
HYG84_RS05935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYG84_RS05970	COG5002	protein histidine kinase activity
HYG84_RS05985	COG0488	(ABC) transporter
HYG84_RS06025	COG0789	Transcriptional regulator
HYG84_RS06045	COG2226	methyltransferase
HYG84_RS06065	COG3708	Transcriptional regulator
HYG84_RS06065	COG2207	Transcriptional regulator
HYG84_RS06080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYG84_RS06085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HYG84_RS06090	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HYG84_RS06095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HYG84_RS06145	COG0488	(ABC) transporter
HYG84_RS06150	COG4555	ABC transporter
HYG84_RS06160	COG0542	response to heat
HYG84_RS06180	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG84_RS06215	COG5002	protein histidine kinase activity
HYG84_RS06215	COG3850	Histidine kinase
HYG84_RS06275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYG84_RS06280	COG1136	(ABC) transporter
HYG84_RS06285	COG0577	efflux transmembrane transporter activity
HYG84_RS06305	COG1024	Enoyl-CoA hydratase
HYG84_RS06310	COG2610	gluconate transmembrane transporter activity
HYG84_RS06325	COG2086	electron transfer activity
HYG84_RS06330	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYG84_RS06335	COG3829	transcription factor binding
HYG84_RS06335	COG3290	protein histidine kinase activity
HYG84_RS06350	COG1696	Membrane protein involved in D-alanine export
HYG84_RS06365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYG84_RS06365	COG0723	plastoquinol--plastocyanin reductase activity
HYG84_RS06410	COG0534	Mate efflux family protein
HYG84_RS06415	COG1053	succinate dehydrogenase
HYG84_RS06415	COG3976	FMN-binding domain protein
HYG84_RS06420	COG2972	Histidine kinase
HYG84_RS06425	COG3279	Response regulator of the LytR AlgR family
HYG84_RS06435	COG0739	heme binding
HYG84_RS06440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYG84_RS06445	COG0765	amino acid transport
HYG84_RS06450	COG1126	abc transporter atp-binding protein
HYG84_RS06455	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HYG84_RS06460	COG1687	branched-chain amino acid
HYG84_RS06465	COG1307	EDD domain protein, DegV family
HYG84_RS06500	COG3275	phosphorelay sensor kinase activity
HYG84_RS06550	COG1012	belongs to the aldehyde dehydrogenase family
HYG84_RS06550	COG1454	alcohol dehydrogenase
HYG84_RS06555	COG1882	Formate acetyltransferase
HYG84_RS06560	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HYG84_RS06590	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HYG84_RS06595	COG4656	Part of a membrane complex involved in electron transport
HYG84_RS06615	COG1454	alcohol dehydrogenase
HYG84_RS06615	COG1012	belongs to the aldehyde dehydrogenase family
HYG84_RS06620	COG4869	propanediol catabolic process
HYG84_RS06630	COG0840	transmembrane signaling receptor activity
HYG84_RS06640	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HYG84_RS06700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYG84_RS06710	COG1757	Na H antiporter
HYG84_RS06730	COG1132	(ABC) transporter
HYG84_RS06750	COG3290	protein histidine kinase activity
HYG84_RS06755	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYG84_RS06755	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYG84_RS06755	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYG84_RS06755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYG84_RS06760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYG84_RS06765	COG2033	superoxide reductase activity
HYG84_RS06775	COG0840	transmembrane signaling receptor activity
HYG84_RS06780	COG0653	protein targeting
HYG84_RS06790	COG0534	Mate efflux family protein
HYG84_RS06810	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HYG84_RS06815	COG0840	transmembrane signaling receptor activity
HYG84_RS06850	COG0628	permease
HYG84_RS06855	COG1028	Short-chain dehydrogenase reductase Sdr
HYG84_RS06860	COG0183	Belongs to the thiolase family
HYG84_RS06865	COG0697	spore germination
HYG84_RS06890	COG1396	sequence-specific DNA binding
HYG84_RS06895	COG0697	spore germination
HYG84_RS06900	COG2068	MobA-Related Protein
HYG84_RS06940	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HYG84_RS06945	COG0573	inorganic phosphate transmembrane transporter activity
HYG84_RS06950	COG0581	inorganic phosphate transmembrane transporter activity
HYG84_RS06955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HYG84_RS06960	COG0704	Plays a role in the regulation of phosphate uptake
HYG84_RS06975	COG0719	Fe-S assembly protein
HYG84_RS06980	COG0719	Fe-S assembly protein
HYG84_RS06985	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYG84_RS06990	COG0822	iron-sulfur transferase activity
HYG84_RS07000	COG1757	Na H antiporter
HYG84_RS07005	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HYG84_RS07020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HYG84_RS07035	COG2385	sporulation resulting in formation of a cellular spore
HYG84_RS07040	COG4466	Protein conserved in bacteria
HYG84_RS07050	COG4187	Peptidase family M20/M25/M40
HYG84_RS07075	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HYG84_RS07080	COG1802	Transcriptional regulator
HYG84_RS07105	COG0697	spore germination
HYG84_RS07110	COG0814	amino acid
HYG84_RS07130	COG5505	Protein of unknown function (DUF819)
HYG84_RS07140	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYG84_RS07160	COG0840	transmembrane signaling receptor activity
HYG84_RS07165	COG0534	Mate efflux family protein
HYG84_RS07170	COG1609	Transcriptional regulator
HYG84_RS07200	COG2378	regulation of single-species biofilm formation
HYG84_RS07215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYG84_RS07220	COG1473	amidohydrolase
HYG84_RS07225	COG2508	Transcriptional regulator
HYG84_RS07235	COG0456	acetyltransferase
HYG84_RS07245	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYG84_RS07250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYG84_RS07255	COG1794	racemase activity, acting on amino acids and derivatives
HYG84_RS07275	COG0840	transmembrane signaling receptor activity
HYG84_RS07280	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYG84_RS07285	COG2770	Histidine kinase
HYG84_RS07285	COG2205	protein histidine kinase activity
HYG84_RS07290	COG0745	RESPONSE REGULATOR receiver
HYG84_RS07300	COG3384	dioxygenase
HYG84_RS07315	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYG84_RS07320	COG0589	response to stress
HYG84_RS07320	COG0475	glutathione-regulated potassium exporter activity
HYG84_RS07370	COG0745	RESPONSE REGULATOR receiver
HYG84_RS07375	COG5002	protein histidine kinase activity
HYG84_RS07385	COG1803	Methylglyoxal synthase
HYG84_RS07395	COG0534	Mate efflux family protein
HYG84_RS07410	COG0322	excinuclease ABC activity
HYG84_RS07420	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HYG84_RS07435	COG1335	isochorismatase
HYG84_RS07440	COG0163	prenyltransferase activity
HYG84_RS07480	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYG84_RS07485	COG2252	PERMEase
HYG84_RS07490	COG0402	S-adenosylhomocysteine deaminase activity
HYG84_RS07515	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYG84_RS07525	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HYG84_RS07530	COG0840	transmembrane signaling receptor activity
HYG84_RS07535	COG1272	protein, Hemolysin III
HYG84_RS07545	COG0511	ligase activity, forming carbon-carbon bonds
HYG84_RS07550	COG0439	Biotin carboxylase
HYG84_RS07555	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HYG84_RS07560	COG0825	malonyl-CoA metabolic process
HYG84_RS07565	COG0789	Transcriptional regulator
HYG84_RS07570	COG1131	(ABC) transporter
HYG84_RS07600	COG2207	Transcriptional regulator
HYG84_RS07600	COG4753	response regulator
HYG84_RS07605	COG2972	Histidine kinase
HYG84_RS07610	COG1053	succinate dehydrogenase
HYG84_RS07610	COG3976	FMN-binding domain protein
HYG84_RS07620	COG1902	pentaerythritol trinitrate reductase activity
HYG84_RS07635	COG0019	diaminopimelate decarboxylase activity
HYG84_RS07640	COG1619	proteins homologs of microcin C7 resistance protein MccF
HYG84_RS07645	COG1473	amidohydrolase
HYG84_RS07665	COG2210	Belongs to the sulfur carrier protein TusA family
HYG84_RS07680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYG84_RS07690	COG3858	chitin binding
HYG84_RS07690	COG1388	LysM domain
HYG84_RS07695	COG0116	Belongs to the methyltransferase superfamily
HYG84_RS07710	COG4948	Mandelate Racemase Muconate Lactonizing
HYG84_RS07720	COG3829	transcription factor binding
HYG84_RS07725	COG0604	alcohol dehydrogenase
HYG84_RS07740	COG1193	negative regulation of DNA recombination
HYG84_RS07745	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HYG84_RS07750	COG5012	cobalamin binding
HYG84_RS07765	COG3279	Response regulator of the LytR AlgR family
HYG84_RS07790	COG2304	oxidoreductase activity
HYG84_RS07800	COG0037	tRNA processing
HYG84_RS07805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYG84_RS07810	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG84_RS07810	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG84_RS07815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG84_RS07815	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG84_RS07825	COG0346	lactoylglutathione lyase activity
HYG84_RS07830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYG84_RS07840	COG4770	biotin carboxylase activity
HYG84_RS07845	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HYG84_RS07850	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HYG84_RS07850	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HYG84_RS07860	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HYG84_RS07865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYG84_RS07875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYG84_RS07880	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HYG84_RS07905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYG84_RS07910	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYG84_RS07915	COG3880	PFAM UvrB UvrC protein
HYG84_RS07920	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HYG84_RS07925	COG0542	response to heat
HYG84_RS07935	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HYG84_RS07950	COG1329	Transcriptional regulator
HYG84_RS07955	COG4956	integral membrane protein (PIN domain superfamily)
HYG84_RS07960	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HYG84_RS07965	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HYG84_RS07970	COG4555	ABC transporter
HYG84_RS07975	COG1668	transmembrane transport
HYG84_RS07980	COG0442	prolyl-tRNA aminoacylation
HYG84_RS07990	COG0745	RESPONSE REGULATOR receiver
HYG84_RS07995	COG2205	protein histidine kinase activity
HYG84_RS08000	COG4086	secreted protein
HYG84_RS08005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYG84_RS08010	COG1045	serine acetyltransferase
HYG84_RS08015	COG0215	cysteine-tRNA ligase activity
HYG84_RS08035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYG84_RS08040	COG3688	RNA-binding protein containing a PIN domain
HYG84_RS08050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYG84_RS08055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYG84_RS08065	COG0250	Participates in transcription elongation, termination and antitermination
HYG84_RS08070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HYG84_RS08075	COG0081	regulation of translation
HYG84_RS08080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HYG84_RS08085	COG0222	ribosome binding
HYG84_RS08090	COG0085	RNA polymerase activity
HYG84_RS08095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HYG84_RS08100	COG1358	cellular component organization or biogenesis
HYG84_RS08105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HYG84_RS08110	COG0049	tRNA binding
HYG84_RS08115	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYG84_RS08120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYG84_RS08125	COG0051	transcription antitermination factor activity, RNA binding
HYG84_RS08130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HYG84_RS08135	COG0088	Forms part of the polypeptide exit tunnel
HYG84_RS08140	COG0089	rRNA binding
HYG84_RS08145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HYG84_RS08150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HYG84_RS08155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HYG84_RS08160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HYG84_RS08165	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HYG84_RS08170	COG0255	Belongs to the universal ribosomal protein uL29 family
HYG84_RS08175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HYG84_RS08180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HYG84_RS08185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HYG84_RS08190	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HYG84_RS08195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYG84_RS08200	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HYG84_RS08205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HYG84_RS08210	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HYG84_RS08215	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HYG84_RS08220	COG1841	ribosomal large subunit assembly
HYG84_RS08225	COG0200	Binds to the 23S rRNA
HYG84_RS08230	COG0201	protein transport
HYG84_RS08235	COG0563	adenylate kinase activity
HYG84_RS08240	COG0024	Methionine aminopeptidase
HYG84_RS08250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HYG84_RS08255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HYG84_RS08260	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HYG84_RS08265	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HYG84_RS08270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYG84_RS08275	COG0202	RNA polymerase activity
HYG84_RS08280	COG0203	ribosomal protein L17
HYG84_RS08285	COG1122	ATPase activity
HYG84_RS08295	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HYG84_RS08300	COG0101	tRNA pseudouridine synthase activity
HYG84_RS08305	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HYG84_RS08310	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HYG84_RS08325	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG84_RS08340	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG84_RS08370	COG0243	molybdopterin cofactor binding
HYG84_RS08375	COG0437	4 iron, 4 sulfur cluster binding
HYG84_RS08385	COG5577	PFAM Coat F domain
HYG84_RS08400	COG0517	IMP dehydrogenase activity
HYG84_RS08400	COG0516	GMP reductase activity
HYG84_RS08405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HYG84_RS08405	COG0519	Catalyzes the synthesis of GMP from XMP
HYG84_RS08410	COG3655	Transcriptional regulator
HYG84_RS08415	COG2252	PERMEase
HYG84_RS08420	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HYG84_RS08425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HYG84_RS08430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYG84_RS08435	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HYG84_RS08440	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HYG84_RS08445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HYG84_RS08450	COG0138	bifunctional purine biosynthesis protein purh
HYG84_RS08455	COG0151	Belongs to the GarS family
HYG84_RS08465	COG0840	transmembrane signaling receptor activity
HYG84_RS08475	COG2011	ABC-type metal ion transport system permease component
HYG84_RS08485	COG0527	aspartate kinase activity
HYG84_RS08490	COG1114	Component of the transport system for branched-chain amino acids
HYG84_RS08495	COG1301	dicarboxylic acid transport
HYG84_RS08500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYG84_RS08505	COG0210	DNA helicase
HYG84_RS08510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYG84_RS08520	COG1592	Rubrerythrin
HYG84_RS08525	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYG84_RS08530	COG0154	amidase activity
HYG84_RS08535	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYG84_RS08545	COG3069	C4-dicarboxylate transmembrane transporter activity
HYG84_RS08570	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HYG84_RS08580	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HYG84_RS08665	COG4824	toxin secretion phage lysis holin
HYG84_RS08725	COG2984	ABC transporter substrate binding protein
HYG84_RS08730	COG3852	Histidine kinase
HYG84_RS08735	COG2204	response regulator
HYG84_RS08760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYG84_RS08765	COG0746	molybdenum cofactor guanylyltransferase activity
HYG84_RS08770	COG0303	'Molybdopterin
HYG84_RS08790	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG84_RS08795	COG3192	ethanolamine utilization protein
HYG84_RS08815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYG84_RS08825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG84_RS08830	COG1120	ATPase activity
HYG84_RS08835	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HYG84_RS08840	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HYG84_RS08845	COG0406	alpha-ribazole phosphatase activity
HYG84_RS08865	COG0840	transmembrane signaling receptor activity
HYG84_RS08895	COG2715	membrane protein required for spore maturation
HYG84_RS08900	COG0700	Nucleoside recognition
HYG84_RS08905	COG0531	amino acid
HYG84_RS08915	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HYG84_RS08920	COG2323	membrane
HYG84_RS08925	COG0697	spore germination
HYG84_RS08940	COG0531	amino acid
HYG84_RS08980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HYG84_RS09020	COG1518	maintenance of DNA repeat elements
HYG84_RS09025	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HYG84_RS09035	COG0617	tRNA 3'-terminal CCA addition
HYG84_RS09035	COG1353	crispr-associated protein
HYG84_RS09050	COG1278	Cold shock
HYG84_RS09055	COG0544	peptidyl-prolyl cis-trans isomerase activity
HYG84_RS09060	COG0740	serine-type endopeptidase activity
HYG84_RS09065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HYG84_RS09070	COG1067	ATP-dependent peptidase activity
HYG84_RS09070	COG0470	DNA polymerase III
HYG84_RS09080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HYG84_RS09085	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HYG84_RS09095	COG0427	acetyl-CoA hydrolase
HYG84_RS09100	COG2985	domain, Protein
HYG84_RS09105	COG1773	rubredoxin
HYG84_RS09145	COG2217	Heavy metal translocating P-type atpase
HYG84_RS09150	COG0549	Belongs to the carbamate kinase family
HYG84_RS09160	COG0540	Belongs to the ATCase OTCase family
HYG84_RS09175	COG3706	GGDEF domain
HYG84_RS09180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYG84_RS09195	COG1924	4 iron, 4 sulfur cluster binding
HYG84_RS09200	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HYG84_RS09200	COG3608	succinylglutamate desuccinylase aspartoacylase
HYG84_RS09210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYG84_RS09215	COG0437	4 iron, 4 sulfur cluster binding
HYG84_RS09220	COG2414	aldehyde ferredoxin oxidoreductase
HYG84_RS09225	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HYG84_RS09240	COG0601	transmembrane transport
HYG84_RS09250	COG0444	Belongs to the ABC transporter superfamily
HYG84_RS09255	COG4608	Belongs to the ABC transporter superfamily
HYG84_RS09265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYG84_RS09275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYG84_RS09280	COG0805	protein transport
HYG84_RS09285	COG0803	Belongs to the bacterial solute-binding protein 9 family
HYG84_RS09285	COG3443	Belongs to the bacterial solute-binding protein 9 family
HYG84_RS09290	COG1121	(ABC) transporter
HYG84_RS09295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYG84_RS09325	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HYG84_RS09335	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYG84_RS09340	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYG84_RS09340	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYG84_RS09370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HYG84_RS09385	COG1307	EDD domain protein, DegV family
HYG84_RS09410	COG2996	Protein conserved in bacteria
HYG84_RS09415	COG1115	amino acid carrier protein
HYG84_RS09450	COG1283	sodium-dependent phosphate transmembrane transporter activity
HYG84_RS09455	COG0726	polysaccharide deacetylase
HYG84_RS09460	COG4242	Belongs to the peptidase S51 family
HYG84_RS09510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYG84_RS09515	COG2208	phosphoserine phosphatase activity
HYG84_RS09520	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYG84_RS09520	COG2199	diguanylate cyclase activity
HYG84_RS09525	COG3711	transcriptional antiterminator
HYG84_RS09535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYG84_RS09540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYG84_RS09560	COG3437	response regulator, receiver
HYG84_RS09565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYG84_RS09580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HYG84_RS09625	COG1116	anion transmembrane transporter activity
HYG84_RS09630	COG5002	protein histidine kinase activity
HYG84_RS09640	COG0475	glutathione-regulated potassium exporter activity
HYG84_RS09660	COG0561	phosphatase activity
HYG84_RS09670	COG0312	modulator of DNA gyrase
HYG84_RS09675	COG0312	modulator of DNA gyrase
HYG84_RS09680	COG3872	metal-dependent enzyme
HYG84_RS09705	COG0772	Belongs to the SEDS family
HYG84_RS09710	COG2239	Acts as a magnesium transporter
HYG84_RS09720	COG2959	enzyme of heme biosynthesis
HYG84_RS09735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HYG84_RS09745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYG84_RS09750	COG0488	(ABC) transporter
HYG84_RS09760	COG2244	polysaccharide biosynthetic process
HYG84_RS09815	COG0500	methyltransferase
HYG84_RS09815	COG3615	Tellurite resistance protein tehB
HYG84_RS09905	COG0745	RESPONSE REGULATOR receiver
HYG84_RS09910	COG5002	protein histidine kinase activity
HYG84_RS09925	COG3681	Belongs to the UPF0597 family
HYG84_RS09935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYG84_RS09950	COG0525	valine-tRNA ligase activity
HYG84_RS09955	COG0285	dihydrofolate synthase activity
HYG84_RS09995	COG1283	sodium-dependent phosphate transmembrane transporter activity
HYG84_RS10000	COG0436	Aminotransferase
HYG84_RS10005	COG0726	polysaccharide deacetylase
HYG84_RS10020	COG4974	Belongs to the 'phage' integrase family
HYG84_RS10130	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HYG84_RS10140	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYG84_RS10145	COG2339	peptidase activity
HYG84_RS10160	COG0681	Belongs to the peptidase S26 family
HYG84_RS10165	COG0517	IMP dehydrogenase activity
HYG84_RS10170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYG84_RS10175	COG2066	Belongs to the glutaminase family
HYG84_RS10185	COG2226	methyltransferase
HYG84_RS10190	COG1278	Cold shock
HYG84_RS10195	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HYG84_RS10225	COG1396	sequence-specific DNA binding
HYG84_RS10255	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG84_RS10275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYG84_RS10290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYG84_RS10320	COG0456	acetyltransferase
HYG84_RS10365	COG1819	glycosyl
HYG84_RS10380	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYG84_RS10385	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYG84_RS10405	COG4399	Belongs to the UPF0754 family
HYG84_RS10405	COG4399	Belongs to the UPF0754 family
HYG84_RS10420	COG4619	ABC transporter
HYG84_RS10425	COG0390	transport system, permease component
HYG84_RS10440	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HYG84_RS10445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HYG84_RS10450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HYG84_RS10455	COG0569	domain protein
HYG84_RS10460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYG84_RS10470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HYG84_RS10475	COG0072	phenylalanine-tRNA ligase activity
HYG84_RS10475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG84_RS10480	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HYG84_RS10540	COG0826	peptidase U32
HYG84_RS10550	COG1666	GTP binding
HYG84_RS10560	COG1846	Transcriptional regulator
HYG84_RS10565	COG0534	Mate efflux family protein
HYG84_RS10590	COG0835	chemotaxis
HYG84_RS10590	COG0784	Response regulator, receiver
HYG84_RS10620	COG0170	dolichyl monophosphate biosynthetic process
HYG84_RS10630	COG2233	PERMEase
HYG84_RS10635	COG0426	domain, Protein
HYG84_RS10680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYG84_RS10690	COG1132	(ABC) transporter
HYG84_RS10695	COG1132	(ABC) transporter
HYG84_RS10700	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG84_RS10700	COG2247	cell wall binding repeat
HYG84_RS10720	COG1058	Belongs to the CinA family
HYG84_RS10720	COG1546	Belongs to the CinA family
HYG84_RS10735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYG84_RS10740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYG84_RS10760	COG1396	sequence-specific DNA binding
HYG84_RS10785	COG2267	carboxylic ester hydrolase activity
HYG84_RS10795	COG1619	proteins homologs of microcin C7 resistance protein MccF
HYG84_RS10805	COG0346	lactoylglutathione lyase activity
HYG84_RS10810	COG0697	spore germination
HYG84_RS10815	COG2207	Transcriptional regulator
HYG84_RS10905	COG0251	oxidation-reduction process
HYG84_RS11015	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HYG84_RS11030	COG1595	DNA-templated transcription, initiation
HYG84_RS11075	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HYG84_RS11105	COG1192	Involved in chromosome partitioning
HYG84_RS11110	COG1475	DNA binding
HYG84_RS11165	COG0629	single-stranded DNA binding
HYG84_RS11250	COG1396	sequence-specific DNA binding
HYG84_RS11275	COG3344	reverse transcriptase
HYG84_RS11305	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYG84_RS11310	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYG84_RS11320	COG1592	Rubrerythrin
HYG84_RS11325	COG2081	HI0933 family
HYG84_RS11330	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HYG84_RS11340	COG1217	gtp-binding protein TYPA
HYG84_RS11350	COG1193	negative regulation of DNA recombination
HYG84_RS11355	COG1683	Conserved Protein
HYG84_RS11360	COG0018	arginyl-trna synthetase
HYG84_RS11380	COG1032	radical SAM domain protein
HYG84_RS11395	COG0280	phosphate acetyltransferase
HYG84_RS11540	COG1361	Conserved repeat domain
HYG84_RS11540	COG3266	domain, Protein
HYG84_RS11540	COG2911	Protein conserved in bacteria
HYG84_RS11545	COG0210	DNA helicase
HYG84_RS11560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYG84_RS11570	COG1104	cysteine desulfurase activity
HYG84_RS11575	COG0301	tRNA thio-modification
HYG84_RS11585	COG0521	Mo-molybdopterin cofactor biosynthetic process
HYG84_RS11590	COG1950	PFAM Membrane protein of
HYG84_RS11600	COG0519	Catalyzes the synthesis of GMP from XMP
HYG84_RS11610	COG2172	sigma factor antagonist activity
HYG84_RS11615	COG1191	sigma factor activity
HYG84_RS11640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG84_RS11665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYG84_RS11680	COG1739	Uncharacterized protein family UPF0029
HYG84_RS11700	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYG84_RS11705	COG0217	transcriptional regulatory protein
HYG84_RS11715	COG2153	protein acetylation
HYG84_RS11735	COG0217	transcriptional regulatory protein
HYG84_RS11740	COG3103	Sh3 type 3 domain protein
HYG84_RS11740	COG1388	LysM domain
HYG84_RS11740	COG0791	NLP P60 protein
HYG84_RS11745	COG0741	lytic transglycosylase activity
HYG84_RS11755	COG4656	Part of a membrane complex involved in electron transport
HYG84_RS11760	COG4658	electron transport chain
HYG84_RS11765	COG4659	FMN binding
HYG84_RS11770	COG4660	Part of a membrane complex involved in electron transport
HYG84_RS11775	COG4657	Part of a membrane complex involved in electron transport
HYG84_RS11780	COG1245	4Fe-4S binding domain
HYG84_RS11780	COG2878	Part of a membrane complex involved in electron transport
HYG84_RS11795	COG0424	maF-like protein
HYG84_RS11800	COG2003	Belongs to the UPF0758 family
HYG84_RS11805	COG1077	Cell shape determining protein MreB Mrl
HYG84_RS11820	COG0768	penicillin binding
HYG84_RS11825	COG0850	regulation of cytokinetic process
HYG84_RS11830	COG2894	cell division
HYG84_RS11835	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HYG84_RS11860	COG1530	ribonuclease E activity
HYG84_RS11865	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HYG84_RS11880	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYG84_RS11890	COG1534	Rna-binding protein
HYG84_RS11900	COG1713	HD superfamily hydrolase involved in NAD metabolism
HYG84_RS11905	COG1316	TRANSCRIPTIONal
HYG84_RS11910	COG0530	calcium, potassium:sodium antiporter activity
HYG84_RS11915	COG0799	negative regulation of ribosome biogenesis
HYG84_RS11925	COG0251	oxidation-reduction process
HYG84_RS11930	COG1760	l-serine dehydratase
HYG84_RS11935	COG1760	l-serine dehydratase
HYG84_RS11940	COG1686	Belongs to the peptidase S11 family
HYG84_RS11945	COG1555	photosystem II stabilization
HYG84_RS11945	COG1596	polysaccharide export
HYG84_RS11955	COG1115	amino acid carrier protein
HYG84_RS11960	COG1921	L-seryl-tRNASec selenium transferase activity
HYG84_RS11970	COG0745	RESPONSE REGULATOR receiver
HYG84_RS11975	COG5002	protein histidine kinase activity
HYG84_RS11985	COG1187	pseudouridine synthase activity
HYG84_RS11990	COG1268	BioY protein
HYG84_RS12015	COG2155	Conserved Protein
HYG84_RS12025	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HYG84_RS12030	COG0632	four-way junction helicase activity
HYG84_RS12035	COG2255	four-way junction helicase activity
HYG84_RS12040	COG2247	cell wall binding repeat
HYG84_RS12040	COG2385	sporulation resulting in formation of a cellular spore
HYG84_RS12055	COG1862	Preprotein translocase
HYG84_RS12070	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYG84_RS12080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYG84_RS12085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYG84_RS12090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HYG84_RS12090	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HYG84_RS12095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYG84_RS12100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYG84_RS12105	COG1490	D-aminoacyl-tRNA deacylase activity
HYG84_RS12110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYG84_RS12115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYG84_RS12120	COG0124	histidyl-tRNA synthetase
HYG84_RS12140	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HYG84_RS12205	COG1362	aminopeptidase activity
HYG84_RS12260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HYG84_RS12265	COG3804	dihydrodipicolinate reductase
HYG84_RS12275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYG84_RS12285	COG5012	cobalamin binding
HYG84_RS12295	COG3457	Alanine racemase
HYG84_RS12320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HYG84_RS12355	COG0010	Belongs to the arginase family
HYG84_RS12385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYG84_RS12410	COG3682	Transcriptional regulator
HYG84_RS12425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYG84_RS12445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYG84_RS12450	COG0798	PFAM Bile acid sodium symporter
HYG84_RS12460	COG0326	Molecular chaperone. Has ATPase activity
HYG84_RS12480	COG2340	Cysteine-rich secretory protein family
HYG84_RS12500	COG1959	2 iron, 2 sulfur cluster binding
HYG84_RS12525	COG0628	permease
HYG84_RS12530	COG0740	serine-type endopeptidase activity
HYG84_RS12535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYG84_RS12540	COG4472	Bacterial protein of unknown function (DUF965)
HYG84_RS12550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HYG84_RS12555	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HYG84_RS12560	COG3906	Belongs to the UPF0473 family
HYG84_RS12565	COG0735	belongs to the Fur family
HYG84_RS12570	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HYG84_RS12585	COG4122	O-methyltransferase activity
HYG84_RS12590	COG0826	peptidase U32
HYG84_RS12595	COG0572	uridine kinase
HYG84_RS12600	COG0768	penicillin binding
HYG84_RS12640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYG84_RS12645	COG0746	molybdenum cofactor guanylyltransferase activity
HYG84_RS12670	COG0243	molybdopterin cofactor binding
HYG84_RS12675	COG0437	4 iron, 4 sulfur cluster binding
HYG84_RS12685	COG0488	(ABC) transporter
HYG84_RS12785	COG3266	domain, Protein
HYG84_RS12785	COG2911	Protein conserved in bacteria
HYG84_RS12785	COG1361	Conserved repeat domain
HYG84_RS12795	COG3344	reverse transcriptase
HYG84_RS12865	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HYG84_RS12870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HYG84_RS12875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HYG84_RS12885	COG1459	type II secretion system
HYG84_RS12910	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HYG84_RS12935	COG1361	Conserved repeat domain
HYG84_RS12940	COG4970	Tfp pilus assembly protein FimT
HYG84_RS12965	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HYG84_RS12970	COG0006	proline dipeptidase activity
HYG84_RS12975	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HYG84_RS12985	COG3854	ATPases associated with a variety of cellular activities
HYG84_RS13025	COG1302	Protein conserved in bacteria
HYG84_RS13030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYG84_RS13035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HYG84_RS13040	COG1570	exodeoxyribonuclease VII activity
HYG84_RS13045	COG1722	exodeoxyribonuclease VII activity
HYG84_RS13050	COG0142	geranyltranstransferase activity
HYG84_RS13055	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HYG84_RS13065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HYG84_RS13070	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HYG84_RS13075	COG1438	arginine binding
HYG84_RS13080	COG0497	DNA recombination
HYG84_RS13085	COG0750	zinc metalloprotease
HYG84_RS13095	COG2207	Transcriptional regulator
HYG84_RS13095	COG1917	Cupin 2, conserved barrel domain protein
HYG84_RS13100	COG0582	viral genome integration into host DNA
HYG84_RS13105	COG2137	regulation of response to DNA damage stimulus
HYG84_RS13120	COG0463	Glycosyl transferase, family 2
HYG84_RS13145	COG4974	Belongs to the 'phage' integrase family
HYG84_RS13150	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HYG84_RS13160	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HYG84_RS13170	COG1686	Belongs to the peptidase S11 family
HYG84_RS13175	COG1994	Peptidase M50
HYG84_RS13180	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HYG84_RS13185	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HYG84_RS13190	COG0010	Belongs to the arginase family
HYG84_RS13195	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYG84_RS13200	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HYG84_RS13215	COG3874	Sporulation protein YtfJ
HYG84_RS13225	COG1686	Belongs to the peptidase S11 family
HYG84_RS13235	COG0445	tRNA wobble uridine modification
HYG84_RS13240	COG1187	pseudouridine synthase activity
HYG84_RS13250	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HYG84_RS13255	COG0511	ligase activity, forming carbon-carbon bonds
HYG84_RS13255	COG5016	pyruvate
HYG84_RS13265	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HYG84_RS13275	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYG84_RS13275	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYG84_RS13280	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYG84_RS13295	COG0406	alpha-ribazole phosphatase activity
HYG84_RS13300	COG2081	HI0933 family
HYG84_RS13315	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HYG84_RS13320	COG0204	Acyl-transferase
HYG84_RS13325	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HYG84_RS13335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HYG84_RS13345	COG1363	Peptidase, m42
HYG84_RS13355	COG0789	Transcriptional regulator
HYG84_RS13360	COG0436	Aminotransferase
HYG84_RS13370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYG84_RS13375	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYG84_RS13380	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HYG84_RS13385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HYG84_RS13390	COG1923	regulation of RNA biosynthetic process
HYG84_RS13395	COG0464	growth
HYG84_RS13400	COG1160	GTP binding
HYG84_RS13415	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HYG84_RS13420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYG84_RS13425	COG4974	Belongs to the 'phage' integrase family
HYG84_RS13440	COG3858	chitin binding
HYG84_RS13445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYG84_RS13460	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYG84_RS13470	COG0693	protein deglycase activity
HYG84_RS13495	COG0613	PHP domain protein
HYG84_RS13500	COG2359	stage V sporulation protein S
HYG84_RS13505	COG1418	mRNA catabolic process
HYG84_RS13515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYG84_RS13520	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HYG84_RS13525	COG1674	ftsk spoiiie
HYG84_RS13530	COG0740	serine-type endopeptidase activity
HYG84_RS13540	COG0612	Peptidase, M16
HYG84_RS13545	COG0726	polysaccharide deacetylase
HYG84_RS13550	COG1185	polyribonucleotide nucleotidyltransferase activity
HYG84_RS13555	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HYG84_RS13560	COG0196	riboflavin kinase activity
HYG84_RS13565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HYG84_RS13570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HYG84_RS13575	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HYG84_RS13580	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HYG84_RS13590	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HYG84_RS13595	COG0195	Participates in both transcription termination and antitermination
HYG84_RS13600	COG0779	Required for maturation of 30S ribosomal subunits
HYG84_RS13610	COG0463	Glycosyl transferase, family 2
HYG84_RS13615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HYG84_RS13620	COG0750	zinc metalloprotease
HYG84_RS13625	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HYG84_RS13630	COG0575	Belongs to the CDS family
HYG84_RS13645	COG0233	cytoplasmic translational termination
HYG84_RS13650	COG0528	UMP kinase activity
HYG84_RS13655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYG84_RS13660	COG0052	Belongs to the universal ribosomal protein uS2 family
HYG84_RS13675	COG1191	sigma factor activity
HYG84_RS13680	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HYG84_RS13685	COG1776	CheC inhibitor of MCP methylation
HYG84_RS13690	COG0835	chemotaxis
HYG84_RS13695	COG0643	Histidine kinase
HYG84_RS13695	COG2198	Histidine kinase
HYG84_RS13700	COG2201	protein-glutamate methylesterase activity
HYG84_RS13715	COG1419	protein localization to endoplasmic reticulum
HYG84_RS13720	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYG84_RS13725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYG84_RS13730	COG1684	flagellar biosynthetic protein fliR
HYG84_RS13735	COG1987	bacterial-type flagellum assembly
HYG84_RS13740	COG1338	Plays a role in the flagellum-specific transport system
HYG84_RS13750	COG2201	protein-glutamate methylesterase activity
HYG84_RS13755	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYG84_RS13755	COG1776	CheC inhibitor of MCP methylation
HYG84_RS13760	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYG84_RS13770	COG1360	Flagellar Motor Protein
HYG84_RS13795	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HYG84_RS13815	COG1157	protein secretion by the type III secretion system
HYG84_RS13825	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYG84_RS13835	COG1677	Flagellar hook-basal body complex protein FliE
HYG84_RS13845	COG1815	bacterial-type flagellum-dependent cell motility
HYG84_RS13855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYG84_RS13860	COG0758	DNA mediated transformation
HYG84_RS13870	COG0792	nuclease activity
HYG84_RS13875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HYG84_RS13885	COG0335	large ribosomal subunit rRNA binding
HYG84_RS13890	COG0336	Belongs to the RNA methyltransferase TrmD family
HYG84_RS13895	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HYG84_RS13900	COG1837	Belongs to the UPF0109 family
HYG84_RS13905	COG0228	four-way junction DNA binding
HYG84_RS13910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HYG84_RS13920	COG0552	protein localization to endoplasmic reticulum
HYG84_RS13925	COG1196	nuclear chromosome segregation
HYG84_RS13935	COG0571	ribonuclease III activity
HYG84_RS13940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYG84_RS13945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYG84_RS13950	COG1028	Short-chain dehydrogenase reductase Sdr
HYG84_RS13955	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYG84_RS13965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG84_RS13970	COG0416	fatty acid biosynthetic process
HYG84_RS13980	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HYG84_RS13985	COG1399	metal-binding, possibly nucleic acid-binding protein
HYG84_RS13990	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HYG84_RS13995	COG1323	Belongs to the UPF0348 family
HYG84_RS14000	COG3314	Sporulation integral membrane protein YlbJ
HYG84_RS14010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HYG84_RS14015	COG0742	ribosomal rna small subunit methyltransferase
HYG84_RS14020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HYG84_RS14025	COG1461	Dihydroxyacetone kinase
HYG84_RS14030	COG1302	Protein conserved in bacteria
HYG84_RS14035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYG84_RS14050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYG84_RS14055	COG1162	GTPase activity
HYG84_RS14060	COG0515	serine threonine protein kinase
HYG84_RS14060	COG2815	serine threonine protein kinase
HYG84_RS14065	COG0631	protein serine/threonine phosphatase activity
HYG84_RS14070	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYG84_RS14075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYG84_RS14075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYG84_RS14080	COG2738	Putative neutral zinc metallopeptidase
HYG84_RS14090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HYG84_RS14095	COG0242	peptide deformylase activity
HYG84_RS14100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HYG84_RS14105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HYG84_RS14110	COG1758	RNA polymerase activity
HYG84_RS14115	COG0194	GDP metabolic process
HYG84_RS14120	COG2052	Domain of unknown function (DUF370)
HYG84_RS14125	COG1561	YicC-like family, N-terminal region
HYG84_RS14130	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HYG84_RS14145	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HYG84_RS14150	COG0564	pseudouridine synthase activity
HYG84_RS14155	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HYG84_RS14160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HYG84_RS14170	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HYG84_RS14175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HYG84_RS14180	COG3599	regulation of cell shape
HYG84_RS14185	COG2302	S4 RNA-binding domain
HYG84_RS14195	COG1799	cell septum assembly
HYG84_RS14200	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HYG84_RS14215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYG84_RS14235	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
HYG84_RS14240	COG0583	DNA-binding transcription factor activity
HYG84_RS14280	COG4974	Belongs to the 'phage' integrase family
HYG84_RS14290	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HYG84_RS14295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HYG84_RS14300	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HYG84_RS14305	COG1160	GTP binding
HYG84_RS14345	COG5002	protein histidine kinase activity
HYG84_RS14350	COG0745	RESPONSE REGULATOR receiver
HYG84_RS14355	COG1496	oxidoreductase activity
HYG84_RS14360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYG84_RS14365	COG1873	PFAM PRC-barrel domain
HYG84_RS14370	COG1191	sigma factor activity
HYG84_RS14375	COG1191	sigma factor activity
HYG84_RS14385	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HYG84_RS14390	COG3856	small basic protein
HYG84_RS14405	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HYG84_RS14410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYG84_RS14415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYG84_RS14420	COG0772	Belongs to the SEDS family
HYG84_RS14425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HYG84_RS14430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYG84_RS14435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYG84_RS14440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYG84_RS14445	COG0768	penicillin binding
HYG84_RS14455	COG0275	rRNA processing
HYG84_RS14460	COG2001	Belongs to the MraZ family
HYG84_RS14470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HYG84_RS14475	COG0612	Peptidase, M16
HYG84_RS14480	COG0612	Peptidase, M16
HYG84_RS14495	COG0012	GTP binding
HYG84_RS14500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYG84_RS14515	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HYG84_RS14520	COG4869	propanediol catabolic process
HYG84_RS14525	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HYG84_RS14530	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HYG84_RS14535	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HYG84_RS14555	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HYG84_RS14560	COG2096	Adenosyltransferase
HYG84_RS14565	COG4608	Belongs to the ABC transporter superfamily
HYG84_RS14570	COG0444	Belongs to the ABC transporter superfamily
HYG84_RS14575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG84_RS14580	COG0601	transmembrane transport
HYG84_RS14585	COG0747	negative chemotaxis
HYG84_RS14590	COG4608	Belongs to the ABC transporter superfamily
HYG84_RS14595	COG0444	Belongs to the ABC transporter superfamily
HYG84_RS14600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG84_RS14605	COG0601	transmembrane transport
HYG84_RS14610	COG0747	negative chemotaxis
HYG84_RS14615	COG2030	dehydratase
HYG84_RS14625	COG4608	Belongs to the ABC transporter superfamily
HYG84_RS14630	COG0444	Belongs to the ABC transporter superfamily
HYG84_RS14635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG84_RS14640	COG0601	transmembrane transport
HYG84_RS14670	COG3275	phosphorelay sensor kinase activity
HYG84_RS14680	COG1966	Carbon starvation protein
HYG84_RS14690	COG1695	Transcriptional regulator
HYG84_RS14705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYG84_RS14725	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYG84_RS14730	COG2384	SAM-dependent methyltransferase
HYG84_RS14740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYG84_RS14745	COG0358	DNA primase activity
HYG84_RS14750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HYG84_RS14765	COG1695	Transcriptional regulator
HYG84_RS14775	COG0251	oxidation-reduction process
HYG84_RS14785	COG0251	oxidation-reduction process
HYG84_RS14795	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYG84_RS14815	COG1307	EDD domain protein, DegV family
HYG84_RS14850	COG1396	sequence-specific DNA binding
HYG84_RS14855	COG1053	succinate dehydrogenase
HYG84_RS14855	COG3976	FMN-binding domain protein
HYG84_RS14855	COG0431	NADPH-dependent FMN reductase
HYG84_RS14875	COG5002	protein histidine kinase activity
HYG84_RS14905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYG84_RS14905	COG0574	Belongs to the PEP-utilizing enzyme family
HYG84_RS14910	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HYG84_RS14915	COG0517	IMP dehydrogenase activity
HYG84_RS14920	COG0423	glycine-tRNA ligase activity
HYG84_RS14925	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYG84_RS14930	COG1381	Involved in DNA repair and RecF pathway recombination
HYG84_RS14940	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HYG84_RS14945	COG0295	cytidine deaminase activity
HYG84_RS14950	COG1470	cell adhesion involved in biofilm formation
HYG84_RS14960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HYG84_RS14965	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HYG84_RS14970	COG1480	7TM receptor with intracellular HD hydrolase
HYG84_RS14975	COG1702	phosphate starvation-inducible protein PhoH
HYG84_RS15010	COG4864	UPF0365 protein
HYG84_RS15015	COG1030	water channel activity
HYG84_RS15025	COG1610	YqeY-like protein
HYG84_RS15030	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HYG84_RS15035	COG0537	adenosine 5'-monophosphoramidase activity
HYG84_RS15040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYG84_RS15050	COG1674	ftsk spoiiie
HYG84_RS15255	COG0175	sulfate reduction
HYG84_RS15340	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HYG84_RS15345	COG2264	protein methyltransferase activity
HYG84_RS15350	COG0484	heat shock protein binding
HYG84_RS15355	COG0443	Heat shock 70 kDa protein
HYG84_RS15360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HYG84_RS15365	COG1420	regulation of RNA biosynthetic process
HYG84_RS15370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYG84_RS15375	COG0481	GTPase activity
HYG84_RS15390	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HYG84_RS15395	COG0268	Binds directly to 16S ribosomal RNA
HYG84_RS15405	COG0658	competence protein
HYG84_RS15405	COG2333	competence protein COMEC
HYG84_RS15425	COG2333	competence protein COMEC
HYG84_RS15425	COG0658	competence protein
HYG84_RS15450	COG0513	Belongs to the DEAD box helicase family
HYG84_RS15455	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HYG84_RS15460	COG1012	belongs to the aldehyde dehydrogenase family
HYG84_RS15470	COG0577	efflux transmembrane transporter activity
HYG84_RS15470	COG1136	(ABC) transporter
HYG84_RS15505	COG0237	dephospho-CoA kinase activity
HYG84_RS15510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG84_RS15510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG84_RS15520	COG1595	DNA-templated transcription, initiation
HYG84_RS15535	COG2357	RelA SpoT domain protein
HYG84_RS15550	COG0583	DNA-binding transcription factor activity
HYG84_RS15555	COG1307	EDD domain protein, DegV family
HYG84_RS15575	COG0835	chemotaxis
HYG84_RS15580	COG4224	UPF0291 protein
HYG84_RS15595	COG1228	amidohydrolase
HYG84_RS15600	COG2986	histidine ammonia-lyase
HYG84_RS15605	COG3706	GGDEF domain
HYG84_RS15610	COG1846	Transcriptional regulator
HYG84_RS15615	COG1597	lipid kinase activity
HYG84_RS15620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYG84_RS15630	COG1132	(ABC) transporter
HYG84_RS15635	COG1132	(ABC) transporter
HYG84_RS15650	COG2199	diguanylate cyclase activity
HYG84_RS15655	COG2244	polysaccharide biosynthetic process
HYG84_RS15675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYG84_RS15690	COG0534	Mate efflux family protein
HYG84_RS15695	COG0564	pseudouridine synthase activity
HYG84_RS15700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HYG84_RS15710	COG3383	formate dehydrogenase (NAD+) activity
HYG84_RS15715	COG0437	4 iron, 4 sulfur cluster binding
HYG84_RS15735	COG1164	Oligoendopeptidase f
HYG84_RS15740	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HYG84_RS15745	COG1053	succinate dehydrogenase
HYG84_RS15765	COG4659	FMN binding
HYG84_RS15785	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HYG84_RS15790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYG84_RS15795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HYG84_RS15815	COG2094	Belongs to the DNA glycosylase MPG family
HYG84_RS15835	COG0406	alpha-ribazole phosphatase activity
HYG84_RS15840	COG2824	Alkylphosphonate utilization operon protein PhnA
HYG84_RS15850	COG0658	competence protein
HYG84_RS15850	COG2333	competence protein COMEC
HYG84_RS15855	COG0840	transmembrane signaling receptor activity
HYG84_RS15860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG84_RS15890	COG1285	pathogenesis
HYG84_RS15920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HYG84_RS15930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HYG84_RS15980	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYG84_RS16100	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HYG84_RS16170	COG1484	DNA-dependent DNA replication
HYG84_RS16200	COG1396	sequence-specific DNA binding
HYG84_RS16210	COG0582	viral genome integration into host DNA
HYG84_RS16220	COG2268	Band 7 protein
HYG84_RS16235	COG1983	PspC domain protein
HYG84_RS16245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYG84_RS16250	COG3314	Sporulation integral membrane protein YlbJ
HYG84_RS16255	COG0037	tRNA processing
HYG84_RS16260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYG84_RS16270	COG1846	Transcriptional regulator
HYG84_RS16295	COG0583	DNA-binding transcription factor activity
HYG84_RS16300	COG2391	methyltransferase activity
HYG84_RS16310	COG2391	methyltransferase activity
HYG84_RS16315	COG0450	alkyl hydroperoxide reductase
HYG84_RS16320	COG3973	AAA domain
HYG84_RS16330	COG0583	DNA-binding transcription factor activity
HYG84_RS16335	COG0514	ATP-dependent DNA helicase (RecQ)
HYG84_RS16345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HYG84_RS16350	COG0581	inorganic phosphate transmembrane transporter activity
HYG84_RS16355	COG0573	inorganic phosphate transmembrane transporter activity
HYG84_RS16365	COG0733	neurotransmitter:sodium symporter activity
HYG84_RS16405	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HYG84_RS16415	COG1120	ATPase activity
HYG84_RS16420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG84_RS16425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYG84_RS16430	COG2205	protein histidine kinase activity
HYG84_RS16445	COG0745	RESPONSE REGULATOR receiver
HYG84_RS16460	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HYG84_RS16465	COG2205	protein histidine kinase activity
HYG84_RS16470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG84_RS16470	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG84_RS16475	COG2362	D-Aminopeptidase
HYG84_RS16480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG84_RS16490	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYG84_RS16495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HYG84_RS16505	COG0500	methyltransferase
HYG84_RS16525	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HYG84_RS16535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HYG84_RS16570	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYG84_RS16595	COG0076	glutamate decarboxylase activity
HYG84_RS16600	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HYG84_RS16605	COG3973	AAA domain
HYG84_RS16615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HYG84_RS16620	COG0557	exoribonuclease II activity
HYG84_RS16635	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYG84_RS16640	COG0148	phosphopyruvate hydratase activity
HYG84_RS16650	COG0149	triose-phosphate isomerase activity
HYG84_RS16655	COG0126	phosphoglycerate kinase activity
HYG84_RS16670	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HYG84_RS16675	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYG84_RS16680	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYG84_RS16685	COG3845	ABC transporter
HYG84_RS16690	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HYG84_RS16695	COG1328	CTP reductase activity
HYG84_RS16700	COG1744	ABC transporter substrate-binding protein PnrA-like
HYG84_RS16730	COG3118	belongs to the thioredoxin family
HYG84_RS16745	COG1307	EDD domain protein, DegV family
HYG84_RS16750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HYG84_RS16755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYG84_RS16775	COG0488	(ABC) transporter
HYG84_RS16790	COG1012	belongs to the aldehyde dehydrogenase family
HYG84_RS16800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HYG84_RS16800	COG0646	methionine synthase
HYG84_RS16805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYG84_RS16825	COG0583	DNA-binding transcription factor activity
HYG84_RS16835	COG1971	Probably functions as a manganese efflux pump
HYG84_RS16840	COG1116	anion transmembrane transporter activity
HYG84_RS16880	COG0737	Belongs to the 5'-nucleotidase family
HYG84_RS16885	COG0561	phosphatase activity
HYG84_RS16890	COG0735	belongs to the Fur family
HYG84_RS16895	COG1120	ATPase activity
HYG84_RS16900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG84_RS16905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYG84_RS16915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYG84_RS16925	COG2720	vancomycin resistance protein
HYG84_RS16945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYG84_RS16950	COG0156	8-amino-7-oxononanoate synthase activity
HYG84_RS16955	COG1067	ATP-dependent peptidase activity
HYG84_RS16965	COG0681	Belongs to the peptidase S26 family
HYG84_RS16990	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG84_RS17030	COG3299	homolog of phage Mu protein gp47
HYG84_RS17045	COG4193	domain, Protein
HYG84_RS17135	COG3728	DNA packaging
HYG84_RS17135	COG5484	DNA packaging
HYG84_RS17155	COG0443	Heat shock 70 kDa protein
HYG84_RS17185	COG0863	Belongs to the N(4) N(6)-methyltransferase family
HYG84_RS17285	COG3645	SOS response
HYG84_RS17285	COG3646	Phage regulatory protein
HYG84_RS17310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HYG84_RS17330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYG84_RS17355	COG0482	sulfurtransferase activity
HYG84_RS17360	COG4545	Glutaredoxin-related protein
HYG84_RS17375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYG84_RS17380	COG3279	Response regulator of the LytR AlgR family
HYG84_RS17385	COG3275	phosphorelay sensor kinase activity
HYG84_RS17425	COG4175	Glycine betaine
HYG84_RS17425	COG0517	IMP dehydrogenase activity
HYG84_RS17430	COG1510	regulation of RNA biosynthetic process
HYG84_RS17450	COG0028	Belongs to the TPP enzyme family
HYG84_RS17460	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HYG84_RS17470	COG1136	(ABC) transporter
HYG84_RS17475	COG3850	Histidine kinase
HYG84_RS17475	COG5002	protein histidine kinase activity
HYG84_RS17490	COG3608	succinylglutamate desuccinylase aspartoacylase
HYG84_RS17490	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HYG84_RS17495	COG0840	transmembrane signaling receptor activity
HYG84_RS17500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYG84_RS17510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYG84_RS17515	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HYG84_RS17520	COG1304	FMN binding
HYG84_RS17525	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HYG84_RS17550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG84_RS17795	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HYG84_RS17845	COG0563	adenylate kinase activity
HYG84_RS18070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYG84_RS18135	COG0653	protein targeting
HYG84_RS18145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HYG84_RS18180	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HYG84_RS18290	COG4974	Belongs to the 'phage' integrase family
HYG84_RS18295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HYG84_RS18305	COG2165	general secretion pathway protein
HYG84_RS18360	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HYG84_RS18375	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HYG84_RS18400	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HYG84_RS18400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HYG84_RS18420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HYG84_RS18495	COG0557	exoribonuclease II activity
HYG84_RS18500	COG0840	transmembrane signaling receptor activity
HYG84_RS18665	COG0358	DNA primase activity
HYG84_RS18715	COG0494	nUDIX hydrolase
HYG84_RS18740	COG0210	DNA helicase
HYG84_RS18830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYG84_RS18850	COG1358	cellular component organization or biogenesis
HYG84_RS18875	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HYG84_RS18895	COG0681	Belongs to the peptidase S26 family
HYG84_RS18935	COG2165	general secretion pathway protein
HYG84_RS18940	COG2133	pyrroloquinoline quinone binding
HYG84_RS18940	COG5183	chlorophyll binding
HYG84_RS19020	COG3266	domain, Protein
HYG84_RS19020	COG2911	Protein conserved in bacteria
HYG84_RS19020	COG1361	Conserved repeat domain
HYG84_RS19120	COG0551	DNA topoisomerase type I activity
HYG84_RS19120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYG84_RS19225	COG0629	single-stranded DNA binding
HYG84_RS19275	COG2337	Toxic component of a toxin-antitoxin (TA) module
HYG84_RS19285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYG84_RS19435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYG84_RS19440	COG0187	DNA topoisomerase II activity
HYG84_RS19450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYG84_RS19485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYG84_RS19490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYG84_RS19525	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HYG84_RS19565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYG84_RS19615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG84_RS19615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG84_RS19650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYG84_RS19675	COG3773	Cell wall hydrolase
HYG84_RS19690	COG2165	general secretion pathway protein
HYG84_RS19710	COG1459	type II secretion system
HYG84_RS19715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HYG84_RS19795	COG2165	general secretion pathway protein
HYG84_RS19820	COG0330	HflC and HflK could
HYG84_RS19825	COG0330	HflC and HflK could
HYG84_RS19830	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HYG84_RS19895	COG4474	Belongs to the UPF0398 family
HYG84_RS19955	COG0793	Belongs to the peptidase S41A family
HYG84_RS19955	COG3409	Peptidoglycan-binding domain 1 protein
HYG84_RS20015	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HYG84_RS20035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG84_RS20035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG84_RS20120	COG2176	DNA-directed DNA polymerase activity
HYG84_RS20230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYG84_RS20240	COG3906	Belongs to the UPF0473 family
HYG84_RS20330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYG84_RS20335	COG1506	peptidase
HYG84_RS20335	COG4946	Tricorn protease homolog
HYG84_RS20335	COG0823	Involved in the tonB-independent uptake of proteins
HYG84_RS20340	COG1376	ErfK ybiS ycfS ynhG family protein
HYG84_RS20370	COG0303	'Molybdopterin
HYG84_RS20385	COG2323	membrane
HYG84_RS20390	COG2323	membrane
HYG84_RS20400	COG1191	sigma factor activity
HYG84_RS20430	COG5566	PFAM Mor transcription activator
HYG84_RS20480	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity