locus-tag	class	description
KWG62_RS00010	COG1904	glucuronate isomerase
KWG62_RS00025	COG0800	Aldolase
KWG62_RS00030	COG0246	Mannitol dehydrogenase
KWG62_RS00035	COG1312	Catalyzes the dehydration of D-mannonate
KWG62_RS00045	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KWG62_RS00080	COG2176	DNA-directed DNA polymerase activity
KWG62_RS00095	COG0493	'glutamate synthase
KWG62_RS00100	COG0070	glutamate synthase
KWG62_RS00100	COG0069	glutamate synthase activity
KWG62_RS00100	COG0067	glutamate synthase
KWG62_RS00105	COG0367	asparagine synthase
KWG62_RS00150	COG2197	response regulator
KWG62_RS00170	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KWG62_RS00200	COG0174	glutamine synthetase
KWG62_RS00210	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KWG62_RS00230	COG0504	CTP synthase activity
KWG62_RS00260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KWG62_RS00270	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KWG62_RS00275	COG1160	GTP binding
KWG62_RS00280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KWG62_RS00285	COG0776	regulation of translation
KWG62_RS00290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KWG62_RS00300	COG1126	abc transporter atp-binding protein
KWG62_RS00305	COG0765	amino acid transport
KWG62_RS00345	COG1358	cellular component organization or biogenesis
KWG62_RS00405	COG1028	Short-chain dehydrogenase reductase Sdr
KWG62_RS00410	COG0446	pyridine nucleotide-disulphide oxidoreductase
KWG62_RS00420	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KWG62_RS00450	COG0561	phosphatase activity
KWG62_RS00470	COG0577	efflux transmembrane transporter activity
KWG62_RS00470	COG1136	(ABC) transporter
KWG62_RS00485	COG0668	transmembrane transport
KWG62_RS00530	COG2188	Transcriptional regulator
KWG62_RS00625	COG0500	methyltransferase
KWG62_RS00635	COG0497	DNA recombination
KWG62_RS00645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KWG62_RS00655	COG1722	exodeoxyribonuclease VII activity
KWG62_RS00660	COG1570	exodeoxyribonuclease VII activity
KWG62_RS00665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KWG62_RS00675	COG0196	riboflavin kinase activity
KWG62_RS00685	COG0037	tRNA processing
KWG62_RS00695	COG1393	Belongs to the ArsC family
KWG62_RS00705	COG2078	PFAM AMMECR1 domain protein
KWG62_RS00705	COG3885	ferrous iron binding
KWG62_RS00710	COG1702	phosphate starvation-inducible protein PhoH
KWG62_RS00715	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KWG62_RS00720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KWG62_RS00725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KWG62_RS00735	COG1187	pseudouridine synthase activity
KWG62_RS00740	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KWG62_RS00765	COG0494	nUDIX hydrolase
KWG62_RS00780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KWG62_RS00830	COG1024	Enoyl-CoA hydratase
KWG62_RS00835	COG1250	3-hydroxyacyl-CoA dehydrogenase
KWG62_RS00845	COG2086	electron transfer activity
KWG62_RS00850	COG1960	acyl-CoA dehydrogenase activity
KWG62_RS00855	COG0183	Belongs to the thiolase family
KWG62_RS00895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KWG62_RS00900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KWG62_RS00910	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KWG62_RS00915	COG0195	Participates in both transcription termination and antitermination
KWG62_RS00920	COG0779	Required for maturation of 30S ribosomal subunits
KWG62_RS00925	COG0194	GDP metabolic process
KWG62_RS00960	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KWG62_RS00965	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KWG62_RS00970	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KWG62_RS00975	COG1609	Transcriptional regulator
KWG62_RS00990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KWG62_RS01000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KWG62_RS01005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KWG62_RS01015	COG1185	polyribonucleotide nucleotidyltransferase activity
KWG62_RS01025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KWG62_RS01030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KWG62_RS01035	COG0481	GTPase activity
KWG62_RS01040	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KWG62_RS01045	COG0268	Binds directly to 16S ribosomal RNA
KWG62_RS01080	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KWG62_RS01085	COG3906	Belongs to the UPF0473 family
KWG62_RS01090	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KWG62_RS01095	COG4472	Bacterial protein of unknown function (DUF965)
KWG62_RS01100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KWG62_RS01105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KWG62_RS01125	COG1648	precorrin-2 dehydrogenase activity
KWG62_RS01125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KWG62_RS01130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KWG62_RS01130	COG1648	precorrin-2 dehydrogenase activity
KWG62_RS01135	COG0494	nUDIX hydrolase
KWG62_RS01140	COG1120	ATPase activity
KWG62_RS01145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KWG62_RS01150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KWG62_RS01215	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KWG62_RS01245	COG0517	IMP dehydrogenase activity
KWG62_RS01245	COG0516	GMP reductase activity
KWG62_RS01250	COG1523	belongs to the glycosyl hydrolase 13 family
KWG62_RS01255	COG0114	fumarate hydratase activity
KWG62_RS01260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KWG62_RS01280	COG0655	NAD(P)H dehydrogenase (quinone) activity
KWG62_RS01285	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KWG62_RS01290	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KWG62_RS01330	COG3436	PFAM IS66 Orf2 family protein
KWG62_RS01370	COG2205	protein histidine kinase activity
KWG62_RS01390	COG0745	RESPONSE REGULATOR receiver
KWG62_RS01395	COG1283	sodium-dependent phosphate transmembrane transporter activity
KWG62_RS01410	COG3328	transposase activity
KWG62_RS01420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KWG62_RS01425	COG2239	Acts as a magnesium transporter
KWG62_RS01430	COG2239	Acts as a magnesium transporter
KWG62_RS01440	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KWG62_RS01445	COG1132	(ABC) transporter
KWG62_RS01450	COG1132	(ABC) transporter
KWG62_RS01485	COG0124	histidyl-tRNA synthetase
KWG62_RS01490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KWG62_RS01500	COG0343	queuine tRNA-ribosyltransferase activity
KWG62_RS01510	COG0326	Molecular chaperone. Has ATPase activity
KWG62_RS01520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KWG62_RS01525	COG3328	transposase activity
KWG62_RS01575	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KWG62_RS01580	COG0151	Belongs to the GarS family
KWG62_RS01590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KWG62_RS01600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KWG62_RS01605	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KWG62_RS01610	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KWG62_RS01615	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KWG62_RS01630	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KWG62_RS01640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KWG62_RS01645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KWG62_RS01660	COG0588	phosphoglycerate mutase activity
KWG62_RS01675	COG0205	6-phosphofructokinase activity
KWG62_RS01685	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KWG62_RS01690	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KWG62_RS01695	COG0561	phosphatase activity
KWG62_RS01710	COG1362	aminopeptidase activity
KWG62_RS01730	COG5002	protein histidine kinase activity
KWG62_RS01735	COG0745	RESPONSE REGULATOR receiver
KWG62_RS01745	COG0140	phosphoribosyl-ATP diphosphatase activity
KWG62_RS01760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KWG62_RS01765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KWG62_RS01775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KWG62_RS01780	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KWG62_RS01785	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KWG62_RS01800	COG0561	phosphatase activity
KWG62_RS01825	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KWG62_RS01830	COG0372	Belongs to the citrate synthase family
KWG62_RS01840	COG0778	Nitroreductase
KWG62_RS01860	COG0538	isocitrate dehydrogenase activity
KWG62_RS01880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KWG62_RS01910	COG1393	Belongs to the ArsC family
KWG62_RS01950	COG1309	transcriptional regulator
KWG62_RS01960	COG1461	Dihydroxyacetone kinase
KWG62_RS01965	COG1302	Protein conserved in bacteria
KWG62_RS01975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KWG62_RS01990	COG0363	glucosamine-6-phosphate deaminase activity
KWG62_RS02005	COG3716	PTS system mannose fructose sorbose family IID component
KWG62_RS02010	COG3715	PTS system
KWG62_RS02015	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KWG62_RS02080	COG0740	serine-type endopeptidase activity
KWG62_RS02095	COG3409	Peptidoglycan-binding domain 1 protein
KWG62_RS02110	COG2222	sugar isomerase
KWG62_RS02130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KWG62_RS02140	COG0281	malic enzyme
KWG62_RS02145	COG2195	Cleaves the N-terminal amino acid of tripeptides
KWG62_RS02295	COG0424	maF-like protein
KWG62_RS02315	COG0083	homoserine kinase activity
KWG62_RS02325	COG0460	homoserine dehydrogenase
KWG62_RS02330	COG0527	aspartate kinase activity
KWG62_RS02335	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KWG62_RS02340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KWG62_RS02370	COG0646	methionine synthase
KWG62_RS02370	COG1410	methionine synthase
KWG62_RS02375	COG0646	methionine synthase
KWG62_RS02375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KWG62_RS02420	COG1278	Cold shock
KWG62_RS02435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KWG62_RS02440	COG0719	Fe-S assembly protein
KWG62_RS02450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KWG62_RS02455	COG0719	Fe-S assembly protein
KWG62_RS02460	COG0396	ATPase activity
KWG62_RS02465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KWG62_RS02625	COG0740	serine-type endopeptidase activity
KWG62_RS02690	COG1403	HNH endonuclease
KWG62_RS02910	COG0740	serine-type endopeptidase activity
KWG62_RS02975	COG1403	HNH endonuclease
KWG62_RS03060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_RS03060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_RS03070	COG4716	Myosin-crossreactive antigen
KWG62_RS03195	COG0542	response to heat
KWG62_RS03220	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KWG62_RS03230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KWG62_RS03235	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
KWG62_RS03235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KWG62_RS03255	COG2176	DNA-directed DNA polymerase activity
KWG62_RS03255	COG5002	protein histidine kinase activity
KWG62_RS03260	COG0739	heme binding
KWG62_RS03310	COG0454	-acetyltransferase
KWG62_RS03335	COG2873	o-acetylhomoserine
KWG62_RS03340	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KWG62_RS03345	COG1028	Short-chain dehydrogenase reductase Sdr
KWG62_RS03350	COG0488	(ABC) transporter
KWG62_RS03395	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KWG62_RS03405	COG0017	Asparaginyl-tRNA synthetase
KWG62_RS03410	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KWG62_RS03445	COG1481	regulation of sporulation
KWG62_RS03450	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KWG62_RS03455	COG1660	Displays ATPase and GTPase activities
KWG62_RS03465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KWG62_RS03490	COG4978	Transcriptional regulator
KWG62_RS03490	COG0789	Transcriptional regulator
KWG62_RS03510	COG1126	abc transporter atp-binding protein
KWG62_RS03515	COG0765	amino acid transport
KWG62_RS03550	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KWG62_RS03560	COG0210	DNA helicase
KWG62_RS03565	COG1597	lipid kinase activity
KWG62_RS03570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KWG62_RS03575	COG1091	dTDP-4-dehydrorhamnose reductase activity
KWG62_RS03590	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KWG62_RS03605	COG1215	transferase activity, transferring glycosyl groups
KWG62_RS03615	COG1316	TRANSCRIPTIONal
KWG62_RS03665	COG0426	domain, Protein
KWG62_RS03755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KWG62_RS03760	COG0009	L-threonylcarbamoyladenylate synthase
KWG62_RS03765	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KWG62_RS03785	COG1696	Membrane protein involved in D-alanine export
KWG62_RS03830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KWG62_RS03860	COG2365	Tyrosine phosphatase family
KWG62_RS03890	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KWG62_RS03905	COG0826	peptidase U32
KWG62_RS03925	COG1051	belongs to the nudix hydrolase family
KWG62_RS03935	COG1609	Transcriptional regulator
KWG62_RS03940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KWG62_RS03945	COG1621	beta-fructofuranosidase activity
KWG62_RS03950	COG1263	PTS System
KWG62_RS03950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KWG62_RS03950	COG2190	(PTS) system
KWG62_RS03955	COG0252	asparaginase activity
KWG62_RS03990	COG3328	transposase activity
KWG62_RS04000	COG1028	Short-chain dehydrogenase reductase Sdr
KWG62_RS04030	COG4211	Belongs to the binding-protein-dependent transport system permease family
KWG62_RS04065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KWG62_RS04080	COG0058	SHG alpha-glucan phosphorylase activity
KWG62_RS04100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KWG62_RS04100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KWG62_RS04120	COG0514	ATP-dependent DNA helicase (RecQ)
KWG62_RS04125	COG2171	N-acyltransferase activity
KWG62_RS04130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KWG62_RS04135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KWG62_RS04155	COG0561	phosphatase activity
KWG62_RS04175	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KWG62_RS04175	COG3291	Pkd domain containing protein
KWG62_RS04210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG62_RS04210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KWG62_RS04210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KWG62_RS04215	COG1105	Belongs to the carbohydrate kinase PfkB family
KWG62_RS04220	COG1349	DNA-binding transcription factor activity
KWG62_RS04225	COG0698	ribose 5-phosphate isomerase
KWG62_RS04230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KWG62_RS04240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KWG62_RS04265	COG0613	PHP domain protein
KWG62_RS04295	COG3142	Participates in the control of copper homeostasis
KWG62_RS04360	COG1454	alcohol dehydrogenase
KWG62_RS04420	COG0653	protein targeting
KWG62_RS04430	COG0561	phosphatase activity
KWG62_RS04465	COG2357	RelA SpoT domain protein
KWG62_RS04470	COG1611	Belongs to the LOG family
KWG62_RS04480	COG0473	3-isopropylmalate dehydrogenase activity
KWG62_RS04490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KWG62_RS04495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KWG62_RS04500	COG1739	Uncharacterized protein family UPF0029
KWG62_RS04535	COG1620	l-lactate permease
KWG62_RS04540	COG2001	Belongs to the MraZ family
KWG62_RS04545	COG0275	rRNA processing
KWG62_RS04555	COG0768	penicillin binding
KWG62_RS04570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KWG62_RS04595	COG0742	ribosomal rna small subunit methyltransferase
KWG62_RS04605	COG2205	protein histidine kinase activity
KWG62_RS04610	COG0745	RESPONSE REGULATOR receiver
KWG62_RS04670	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KWG62_RS04675	COG0789	Transcriptional regulator
KWG62_RS04740	COG0667	Aldo Keto reductase
KWG62_RS04765	COG4133	protoheme IX ABC transporter activity
KWG62_RS04770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KWG62_RS04775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KWG62_RS04780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KWG62_RS04785	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KWG62_RS04790	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KWG62_RS04795	COG0165	Argininosuccinate lyase
KWG62_RS04800	COG0137	argininosuccinate synthase activity
KWG62_RS04845	COG1215	transferase activity, transferring glycosyl groups
KWG62_RS04850	COG0438	transferase activity, transferring glycosyl groups
KWG62_RS04865	COG1473	amidohydrolase
KWG62_RS04870	COG0019	diaminopimelate decarboxylase activity
KWG62_RS04875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KWG62_RS04890	COG2188	Transcriptional regulator
KWG62_RS04895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KWG62_RS04895	COG1263	PTS System
KWG62_RS04900	COG1263	PTS System
KWG62_RS04900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KWG62_RS04940	COG0515	serine threonine protein kinase
KWG62_RS04940	COG3266	domain, Protein
KWG62_RS04945	COG0515	serine threonine protein kinase
KWG62_RS04985	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KWG62_RS05155	COG3250	beta-galactosidase activity
KWG62_RS05190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KWG62_RS05195	COG0581	inorganic phosphate transmembrane transporter activity
KWG62_RS05200	COG0573	inorganic phosphate transmembrane transporter activity
KWG62_RS05250	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KWG62_RS05340	COG1114	Component of the transport system for branched-chain amino acids
KWG62_RS05355	COG1695	Transcriptional regulator
KWG62_RS05370	COG3064	Membrane
KWG62_RS05370	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KWG62_RS05370	COG3583	domain protein
KWG62_RS05385	COG1131	(ABC) transporter
KWG62_RS05390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KWG62_RS05395	COG0656	L-ascorbic acid biosynthetic process
KWG62_RS05400	COG0583	DNA-binding transcription factor activity
KWG62_RS05425	COG1876	peptidase activity
KWG62_RS05455	COG0393	Putative heavy-metal-binding
KWG62_RS05465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KWG62_RS05470	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
KWG62_RS05475	COG3842	ATPase activity
KWG62_RS05490	COG0058	SHG alpha-glucan phosphorylase activity
KWG62_RS05565	COG1876	peptidase activity
KWG62_RS05600	COG0842	Transport permease protein
KWG62_RS05600	COG1131	(ABC) transporter
KWG62_RS05600	COG1716	ATPase activity
KWG62_RS05605	COG1716	ATPase activity
KWG62_RS05675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KWG62_RS05680	COG1420	regulation of RNA biosynthetic process
KWG62_RS05685	COG1496	oxidoreductase activity
KWG62_RS05710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KWG62_RS05730	COG1640	4-alpha-glucanotransferase
KWG62_RS05745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KWG62_RS05755	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KWG62_RS05770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KWG62_RS05810	COG3711	transcriptional antiterminator
KWG62_RS05815	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG62_RS05815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG62_RS05820	COG1105	Belongs to the carbohydrate kinase PfkB family
KWG62_RS05825	COG1063	alcohol dehydrogenase
KWG62_RS05895	COG3118	belongs to the thioredoxin family
KWG62_RS05895	COG0492	ferredoxin-NADP+ reductase activity
KWG62_RS05905	COG1012	belongs to the aldehyde dehydrogenase family
KWG62_RS05910	COG3118	belongs to the thioredoxin family
KWG62_RS05915	COG0628	permease
KWG62_RS05925	COG0741	lytic transglycosylase activity
KWG62_RS05925	COG0791	NLP P60 protein
KWG62_RS05935	COG1316	TRANSCRIPTIONal
KWG62_RS05945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KWG62_RS05990	COG1733	regulation of RNA biosynthetic process
KWG62_RS06010	COG0110	maltose O-acetyltransferase activity
KWG62_RS06025	COG0151	Belongs to the GarS family
KWG62_RS06030	COG0726	polysaccharide deacetylase
KWG62_RS06045	COG0492	ferredoxin-NADP+ reductase activity
KWG62_RS06055	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KWG62_RS06065	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KWG62_RS06070	COG1774	PSP1 C-terminal conserved region
KWG62_RS06080	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KWG62_RS06095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KWG62_RS06110	COG1253	flavin adenine dinucleotide binding
KWG62_RS06115	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KWG62_RS06120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KWG62_RS06125	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KWG62_RS06130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KWG62_RS06135	COG0772	Belongs to the SEDS family
KWG62_RS06160	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KWG62_RS06180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KWG62_RS06190	COG1595	DNA-templated transcription, initiation
KWG62_RS06210	COG2501	S4 domain
KWG62_RS06220	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KWG62_RS06225	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KWG62_RS06235	COG0706	membrane insertase activity
KWG62_RS06240	COG1847	R3H domain protein
KWG62_RS06250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KWG62_RS06255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KWG62_RS06260	COG1078	dGTPase activity
KWG62_RS06270	COG0018	arginyl-trna synthetase
KWG62_RS06275	COG3343	RNA polymerase activity
KWG62_RS06295	COG0357	Ribosomal RNA small subunit methyltransferase G
KWG62_RS06300	COG1192	Involved in chromosome partitioning
KWG62_RS06305	COG1475	DNA binding
KWG62_RS06320	COG0562	UDP-galactopyranose mutase
KWG62_RS06330	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KWG62_RS06345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KWG62_RS06355	COG0084	hydrolase, TatD family'
KWG62_RS06365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KWG62_RS06370	COG2890	protein-(glutamine-N5) methyltransferase activity
KWG62_RS06375	COG0024	Methionine aminopeptidase
KWG62_RS06430	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KWG62_RS06440	COG0463	Glycosyl transferase, family 2
KWG62_RS06445	COG1215	transferase activity, transferring glycosyl groups
KWG62_RS06490	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KWG62_RS06510	COG0561	phosphatase activity
KWG62_RS06540	COG2813	Specifically methylates the guanine in position
KWG62_RS06550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KWG62_RS06560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KWG62_RS06565	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KWG62_RS06585	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KWG62_RS06595	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KWG62_RS06600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KWG62_RS06610	COG1074	ATP-dependent DNA helicase activity
KWG62_RS06615	COG2252	PERMEase
KWG62_RS06630	COG1696	Membrane protein involved in D-alanine export
KWG62_RS06690	COG3842	ATPase activity
KWG62_RS06695	COG1176	ABC-type spermidine putrescine transport system, permease component I
KWG62_RS06700	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KWG62_RS06730	COG0602	queuosine metabolic process
KWG62_RS06745	COG3250	beta-galactosidase activity
KWG62_RS06760	COG1979	alcohol dehydrogenase
KWG62_RS06785	COG2244	polysaccharide biosynthetic process
KWG62_RS06820	COG0438	transferase activity, transferring glycosyl groups
KWG62_RS06830	COG0438	transferase activity, transferring glycosyl groups
KWG62_RS06835	COG3481	metal-dependent phosphohydrolase, HD sub domain
KWG62_RS06840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KWG62_RS06870	COG3769	mannosylglycerate metabolic process
KWG62_RS06890	COG0583	DNA-binding transcription factor activity
KWG62_RS06965	COG1476	TRANSCRIPTIONal
KWG62_RS06975	COG0312	modulator of DNA gyrase
KWG62_RS07035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KWG62_RS07040	COG0505	Belongs to the CarA family
KWG62_RS07045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KWG62_RS07050	COG0543	2 iron, 2 sulfur cluster binding
KWG62_RS07055	COG0167	dihydroorotate dehydrogenase activity
KWG62_RS07090	COG3250	beta-galactosidase activity
KWG62_RS07130	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KWG62_RS07140	COG0747	negative chemotaxis
KWG62_RS07150	COG0601	transmembrane transport
KWG62_RS07165	COG4608	Belongs to the ABC transporter superfamily
KWG62_RS07180	COG0456	acetyltransferase
KWG62_RS07220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KWG62_RS07225	COG0802	atpase or kinase
KWG62_RS07230	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KWG62_RS07235	COG0456	acetyltransferase
KWG62_RS07235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KWG62_RS07245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KWG62_RS07245	COG0519	Catalyzes the synthesis of GMP from XMP
KWG62_RS07250	COG3250	beta-galactosidase activity
KWG62_RS07265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KWG62_RS07270	COG1120	ATPase activity
KWG62_RS07285	COG1136	(ABC) transporter
KWG62_RS07290	COG2205	protein histidine kinase activity
KWG62_RS07305	COG1472	Belongs to the glycosyl hydrolase 3 family
KWG62_RS07310	COG0436	Aminotransferase
KWG62_RS07370	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KWG62_RS07425	COG2738	Putative neutral zinc metallopeptidase
KWG62_RS07445	COG1328	CTP reductase activity
KWG62_RS07450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KWG62_RS07455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KWG62_RS07470	COG2233	PERMEase
KWG62_RS07485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KWG62_RS07495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KWG62_RS07500	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KWG62_RS07505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KWG62_RS07520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KWG62_RS07525	COG0537	adenosine 5'-monophosphoramidase activity
KWG62_RS07530	COG1181	Belongs to the D-alanine--D-alanine ligase family
KWG62_RS07535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KWG62_RS07545	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KWG62_RS07555	COG1160	GTP binding
KWG62_RS07565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KWG62_RS07570	COG0799	negative regulation of ribosome biogenesis
KWG62_RS07575	COG2226	methyltransferase
KWG62_RS07580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KWG62_RS07600	COG0433	COG0433 Predicted ATPase
KWG62_RS07615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KWG62_RS07635	COG3764	Sortase (surface protein transpeptidase)
KWG62_RS07660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KWG62_RS07665	COG1929	Belongs to the glycerate kinase type-1 family
KWG62_RS07680	COG1592	Rubrerythrin
KWG62_RS07695	COG0420	3'-5' exonuclease activity
KWG62_RS07700	COG0419	ATPase involved in DNA repair
KWG62_RS07740	COG3328	transposase activity
KWG62_RS07750	COG0598	Magnesium transport protein CorA
KWG62_RS07755	COG0793	Belongs to the peptidase S41A family
KWG62_RS07755	COG3409	Peptidoglycan-binding domain 1 protein
KWG62_RS07765	COG0285	dihydrofolate synthase activity
KWG62_RS07770	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KWG62_RS07775	COG0556	nucleotide-excision repair
KWG62_RS07780	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KWG62_RS07800	COG0280	phosphate acetyltransferase
KWG62_RS07815	COG3830	Belongs to the UPF0237 family
KWG62_RS07820	COG2848	UPF0210 protein
KWG62_RS07830	COG0765	amino acid transport
KWG62_RS07835	COG1126	abc transporter atp-binding protein
KWG62_RS07870	COG1857	crispr-associated protein
KWG62_RS07885	COG1518	maintenance of DNA repeat elements
KWG62_RS07890	COG2176	DNA-directed DNA polymerase activity
KWG62_RS07920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KWG62_RS07925	COG0081	regulation of translation
KWG62_RS07930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KWG62_RS07960	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
KWG62_RS07965	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KWG62_RS07975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KWG62_RS07980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KWG62_RS07985	COG0531	amino acid
KWG62_RS07990	COG1362	aminopeptidase activity
KWG62_RS08005	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KWG62_RS08015	COG0089	rRNA binding
KWG62_RS08020	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KWG62_RS08035	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KWG62_RS08045	COG0255	Belongs to the universal ribosomal protein uL29 family
KWG62_RS08050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KWG62_RS08055	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KWG62_RS08065	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KWG62_RS08070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KWG62_RS08075	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KWG62_RS08080	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KWG62_RS08085	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KWG62_RS08090	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KWG62_RS08095	COG0200	Binds to the 23S rRNA
KWG62_RS08105	COG0563	adenylate kinase activity
KWG62_RS08110	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KWG62_RS08115	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KWG62_RS08120	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KWG62_RS08125	COG0202	RNA polymerase activity
KWG62_RS08130	COG0203	ribosomal protein L17
KWG62_RS08135	COG4122	O-methyltransferase activity
KWG62_RS08205	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KWG62_RS08210	COG0101	tRNA pseudouridine synthase activity
KWG62_RS08215	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KWG62_RS08220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KWG62_RS08225	COG3842	ATPase activity
KWG62_RS08230	COG1175	transmembrane transport
KWG62_RS08260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KWG62_RS08270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KWG62_RS08275	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KWG62_RS08300	COG0561	phosphatase activity
KWG62_RS08305	COG0778	Nitroreductase
KWG62_RS08310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KWG62_RS08315	COG3331	DNA recombination
KWG62_RS08320	COG3599	regulation of cell shape
KWG62_RS08355	COG0772	Belongs to the SEDS family
KWG62_RS08365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KWG62_RS08370	COG0571	ribonuclease III activity
KWG62_RS08375	COG2176	DNA-directed DNA polymerase activity
KWG62_RS08385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KWG62_RS08390	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KWG62_RS08410	COG0126	phosphoglycerate kinase activity
KWG62_RS08445	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KWG62_RS08455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KWG62_RS08460	COG4481	Protein conserved in bacteria
KWG62_RS08465	COG0012	GTP binding
KWG62_RS08470	COG1994	Peptidase M50
KWG62_RS08500	COG0559	Belongs to the binding-protein-dependent transport system permease family
KWG62_RS08510	COG0411	ABC transporter
KWG62_RS08520	COG0517	IMP dehydrogenase activity
KWG62_RS08520	COG1125	glycine betaine transport
KWG62_RS08555	COG0569	domain protein
KWG62_RS08565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KWG62_RS08570	COG0085	RNA polymerase activity
KWG62_RS08575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KWG62_RS08615	COG2502	aspartate--ammonia ligase
KWG62_RS08620	COG0534	Mate efflux family protein
KWG62_RS08645	COG0028	Belongs to the TPP enzyme family
KWG62_RS08650	COG0440	acetolactate synthase activity
KWG62_RS08660	COG0129	dihydroxy-acid dehydratase activity
KWG62_RS08670	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KWG62_RS08675	COG0251	oxidation-reduction process
KWG62_RS08720	COG0745	RESPONSE REGULATOR receiver
KWG62_RS08820	COG1132	(ABC) transporter
KWG62_RS08825	COG4988	ABC transporter
KWG62_RS08830	COG0488	(ABC) transporter
KWG62_RS08845	COG1725	Transcriptional regulator
KWG62_RS08850	COG1131	(ABC) transporter
KWG62_RS08865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KWG62_RS08885	COG1393	Belongs to the ArsC family
KWG62_RS08895	COG3177	Filamentation induced by cAMP protein fic
KWG62_RS08900	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KWG62_RS08970	COG0733	neurotransmitter:sodium symporter activity
KWG62_RS08995	COG1307	EDD domain protein, DegV family
KWG62_RS09000	COG0360	Binds together with S18 to 16S ribosomal RNA
KWG62_RS09005	COG0629	single-stranded DNA binding
KWG62_RS09010	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KWG62_RS09025	COG0464	growth
KWG62_RS09050	COG3853	Toxic anion resistance protein (TelA)
KWG62_RS09065	COG2310	stress, protein
KWG62_RS09070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KWG62_RS09085	COG0359	binds to the 23S rRNA
KWG62_RS09090	COG0305	Participates in initiation and elongation during chromosome replication
KWG62_RS09115	COG0356	it plays a direct role in the translocation of protons across the membrane
KWG62_RS09125	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KWG62_RS09130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KWG62_RS09135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KWG62_RS09145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KWG62_RS09155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KWG62_RS09180	COG2348	transferase activity, transferring amino-acyl groups
KWG62_RS09235	COG2003	Belongs to the UPF0758 family
KWG62_RS09240	COG1792	Involved in formation and maintenance of cell shape
KWG62_RS09250	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_RS09250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_RS09255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KWG62_RS09260	COG0237	dephospho-CoA kinase activity
KWG62_RS09340	COG0823	Involved in the tonB-independent uptake of proteins
KWG62_RS09340	COG1506	peptidase
KWG62_RS09340	COG4946	Tricorn protease homolog
KWG62_RS09390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KWG62_RS09395	COG0745	RESPONSE REGULATOR receiver
KWG62_RS09400	COG2205	protein histidine kinase activity
KWG62_RS09400	COG2770	Histidine kinase
KWG62_RS09405	COG0673	inositol 2-dehydrogenase activity
KWG62_RS09410	COG1363	Peptidase, m42
KWG62_RS09430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KWG62_RS09435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KWG62_RS09440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KWG62_RS09445	COG1120	ATPase activity
KWG62_RS09475	COG3328	transposase activity
KWG62_RS09485	COG3328	transposase activity
KWG62_RS09525	COG1028	Short-chain dehydrogenase reductase Sdr
KWG62_RS09545	COG1028	Short-chain dehydrogenase reductase Sdr
KWG62_RS09570	COG1737	Transcriptional regulator
KWG62_RS09575	COG0366	Alpha amylase catalytic
KWG62_RS09580	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG62_RS09585	COG3716	PTS system mannose fructose sorbose family IID component
KWG62_RS09595	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG62_RS09595	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KWG62_RS09645	COG1472	Belongs to the glycosyl hydrolase 3 family
KWG62_RS09675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_RS09675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_RS09730	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KWG62_RS09745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KWG62_RS09765	COG1846	Transcriptional regulator
KWG62_RS09770	COG0534	Mate efflux family protein
KWG62_RS09775	COG0110	maltose O-acetyltransferase activity
KWG62_RS09825	COG0640	Transcriptional regulator
KWG62_RS09840	COG2217	Heavy metal translocating P-type atpase
KWG62_RS09860	COG2183	response to ionizing radiation
KWG62_RS09875	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KWG62_RS09890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KWG62_RS09905	COG0612	Peptidase, M16
KWG62_RS09920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KWG62_RS09925	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
KWG62_RS09930	COG1104	cysteine desulfurase activity
KWG62_RS09935	COG0301	tRNA thio-modification
KWG62_RS09940	COG2226	methyltransferase
KWG62_RS09970	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
KWG62_RS09975	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KWG62_RS10015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KWG62_RS10020	COG1546	Belongs to the CinA family
KWG62_RS10020	COG1058	Belongs to the CinA family
KWG62_RS10035	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KWG62_RS10055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KWG62_RS10060	COG2011	ABC-type metal ion transport system permease component
KWG62_RS10065	COG1464	Belongs to the NlpA lipoprotein family
KWG62_RS10070	COG0116	Belongs to the methyltransferase superfamily
KWG62_RS10070	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KWG62_RS10080	COG4821	SIS domain
KWG62_RS10085	COG0210	DNA helicase
KWG62_RS10090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KWG62_RS10100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KWG62_RS10105	COG0154	amidase activity
KWG62_RS10110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KWG62_RS10135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KWG62_RS10145	COG1132	(ABC) transporter
KWG62_RS10150	COG1132	(ABC) transporter
KWG62_RS10165	COG0668	transmembrane transport
KWG62_RS10205	COG0436	Aminotransferase
KWG62_RS10215	COG1595	DNA-templated transcription, initiation
KWG62_RS10235	COG0534	Mate efflux family protein
KWG62_RS10245	COG0656	L-ascorbic acid biosynthetic process
KWG62_RS10250	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KWG62_RS10255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KWG62_RS10265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KWG62_RS10265	COG0072	phenylalanine-tRNA ligase activity
KWG62_RS10290	COG1216	Glycosyl transferase, family 2
KWG62_RS10295	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KWG62_RS10305	COG0534	Mate efflux family protein
KWG62_RS10315	COG0228	four-way junction DNA binding
KWG62_RS10325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KWG62_RS10340	COG0335	large ribosomal subunit rRNA binding
KWG62_RS10345	COG0681	Belongs to the peptidase S26 family
KWG62_RS10355	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KWG62_RS10360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KWG62_RS10365	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KWG62_RS10375	COG0052	Belongs to the universal ribosomal protein uS2 family
KWG62_RS10380	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KWG62_RS10395	COG1151	hydroxylamine reductase activity
KWG62_RS10410	COG2246	polysaccharide biosynthetic process
KWG62_RS10425	COG1131	(ABC) transporter
KWG62_RS10430	COG2188	Transcriptional regulator
KWG62_RS10485	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
KWG62_RS10485	COG3408	Glycogen debranching enzyme
KWG62_RS10600	COG0233	cytoplasmic translational termination
KWG62_RS10605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KWG62_RS10610	COG0575	Belongs to the CDS family
KWG62_RS10615	COG0750	zinc metalloprotease
KWG62_RS10625	COG1272	protein, Hemolysin III
KWG62_RS10635	COG0552	protein localization to endoplasmic reticulum
KWG62_RS10645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KWG62_RS10655	COG0587	DNA-directed DNA polymerase activity
KWG62_RS10660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KWG62_RS10665	COG2868	ribosomal protein
KWG62_RS10670	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KWG62_RS10675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KWG62_RS10680	COG0463	Glycosyl transferase, family 2
KWG62_RS10685	COG0708	Exodeoxyribonuclease III
KWG62_RS10695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KWG62_RS10705	COG0632	four-way junction helicase activity
KWG62_RS10710	COG2255	four-way junction helicase activity
KWG62_RS10715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KWG62_RS10715	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KWG62_RS10720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KWG62_RS10725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KWG62_RS10755	COG1323	Belongs to the UPF0348 family
KWG62_RS10760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KWG62_RS10770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KWG62_RS10775	COG1418	mRNA catabolic process
KWG62_RS10780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KWG62_RS10790	COG1674	ftsk spoiiie
KWG62_RS10810	COG0187	DNA topoisomerase II activity
KWG62_RS10815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KWG62_RS10820	COG3763	UPF0154 protein
KWG62_RS10835	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KWG62_RS10845	COG2326	polyphosphate kinase activity
KWG62_RS10880	COG0564	pseudouridine synthase activity
KWG62_RS10895	COG1193	negative regulation of DNA recombination
KWG62_RS10955	COG0544	peptidyl-prolyl cis-trans isomerase activity
KWG62_RS10965	COG0544	peptidyl-prolyl cis-trans isomerase activity
KWG62_RS10980	COG2348	transferase activity, transferring amino-acyl groups
KWG62_RS10985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KWG62_RS10985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KWG62_RS10990	COG1215	transferase activity, transferring glycosyl groups
KWG62_RS11000	COG0438	transferase activity, transferring glycosyl groups
KWG62_RS11000	COG1216	Glycosyl transferase, family 2
KWG62_RS11015	COG0564	pseudouridine synthase activity
KWG62_RS11035	COG0564	pseudouridine synthase activity
KWG62_RS11040	COG2033	superoxide reductase activity
KWG62_RS11155	COG2984	ABC transporter substrate binding protein
KWG62_RS11160	COG4120	Belongs to the binding-protein-dependent transport system permease family
KWG62_RS11165	COG1122	ATPase activity
KWG62_RS11170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KWG62_RS11175	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KWG62_RS11180	COG0297	glycogen (starch) synthase activity
KWG62_RS11190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG62_RS11200	COG0583	DNA-binding transcription factor activity
KWG62_RS11210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KWG62_RS11255	COG3250	beta-galactosidase activity
KWG62_RS11275	COG2197	response regulator
KWG62_RS11310	COG3708	Transcriptional regulator
KWG62_RS11310	COG2207	Transcriptional regulator
KWG62_RS11315	COG1653	transport
KWG62_RS11330	COG1175	transmembrane transport
KWG62_RS11335	COG0395	ABC-type sugar transport system, permease component
KWG62_RS11340	COG3842	ATPase activity
KWG62_RS11350	COG0205	6-phosphofructokinase activity
KWG62_RS11460	COG0215	cysteine-tRNA ligase activity
KWG62_RS11465	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KWG62_RS11470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KWG62_RS11480	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KWG62_RS11490	COG0250	Participates in transcription elongation, termination and antitermination
KWG62_RS11495	COG1609	Transcriptional regulator
KWG62_RS11500	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KWG62_RS11505	COG0647	UMP catabolic process
KWG62_RS11510	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KWG62_RS11515	COG0557	exoribonuclease II activity
KWG62_RS11525	COG3591	Belongs to the peptidase S1B family
KWG62_RS11545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KWG62_RS11550	COG1132	(ABC) transporter
KWG62_RS11565	COG0662	Cupin 2, conserved barrel domain protein
KWG62_RS11600	COG4120	Belongs to the binding-protein-dependent transport system permease family
KWG62_RS11605	COG3842	ATPase activity
KWG62_RS11620	COG1217	gtp-binding protein TYPA
KWG62_RS11635	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KWG62_RS11640	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KWG62_RS11650	COG1013	pyruvate-flavodoxin oxidoreductase activity
KWG62_RS11650	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KWG62_RS11650	COG0674	pyruvate-flavodoxin oxidoreductase activity
KWG62_RS11650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KWG62_RS11665	COG3250	beta-galactosidase activity
KWG62_RS11680	COG0826	peptidase U32
KWG62_RS11685	COG0442	prolyl-tRNA aminoacylation
KWG62_RS11755	COG1696	Membrane protein involved in D-alanine export
KWG62_RS11775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KWG62_RS11780	COG0768	penicillin binding
KWG62_RS11785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KWG62_RS11790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KWG62_RS11795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KWG62_RS11850	COG1131	(ABC) transporter
KWG62_RS11880	COG3561	AntA/AntB antirepressor
KWG62_RS11925	COG1403	HNH endonuclease
KWG62_RS11970	COG3409	Peptidoglycan-binding domain 1 protein
KWG62_RS11995	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KWG62_RS11995	COG0616	signal peptide processing
KWG62_RS12110	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_RS12110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_RS12130	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KWG62_RS12155	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KWG62_RS12160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KWG62_RS12165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KWG62_RS12170	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
KWG62_RS12200	COG3328	transposase activity
KWG62_RS12225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_RS12225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_RS12270	COG0561	phosphatase activity
KWG62_RS12300	COG3328	transposase activity
KWG62_RS12315	COG1760	l-serine dehydratase
KWG62_RS12320	COG0657	acetylesterase activity
KWG62_RS12325	COG2270	Major facilitator Superfamily
KWG62_RS12330	COG0495	leucyl-tRNA aminoacylation
KWG62_RS12380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KWG62_RS12385	COG0039	L-malate dehydrogenase activity
KWG62_RS12390	COG3328	transposase activity
KWG62_RS12400	COG3328	transposase activity
KWG62_RS12410	COG3328	transposase activity
KWG62_RS12420	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KWG62_RS12425	COG0352	thiamine-phosphate diphosphorylase activity
KWG62_RS12430	COG0352	thiamine-phosphate diphosphorylase activity
KWG62_RS12430	COG0351	phosphomethylpyrimidine kinase
KWG62_RS12440	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KWG62_RS12505	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KWG62_RS12515	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KWG62_RS12530	COG0583	DNA-binding transcription factor activity
KWG62_RS12540	COG4555	ABC transporter
KWG62_RS12545	COG2814	Major facilitator Superfamily
KWG62_RS12565	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KWG62_RS12565	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KWG62_RS12570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KWG62_RS12575	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KWG62_RS12580	COG2843	Capsule synthesis protein
KWG62_RS12585	COG1242	4 iron, 4 sulfur cluster binding
KWG62_RS12590	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KWG62_RS12600	COG1799	cell septum assembly
KWG62_RS12610	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KWG62_RS12615	COG0561	phosphatase activity
KWG62_RS12650	COG3655	Transcriptional regulator
KWG62_RS12655	COG4656	Part of a membrane complex involved in electron transport
KWG62_RS12660	COG4658	electron transport chain
KWG62_RS12670	COG4660	Part of a membrane complex involved in electron transport
KWG62_RS12675	COG4657	Part of a membrane complex involved in electron transport
KWG62_RS12695	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KWG62_RS12700	COG0423	glycine-tRNA ligase activity
KWG62_RS12705	COG0358	DNA primase activity
KWG62_RS12710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KWG62_RS12725	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KWG62_RS12730	COG0513	Belongs to the DEAD box helicase family
KWG62_RS12735	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KWG62_RS12750	COG0628	permease
KWG62_RS12765	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KWG62_RS12770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KWG62_RS12770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KWG62_RS12775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KWG62_RS12785	COG0515	serine threonine protein kinase
KWG62_RS12785	COG2815	serine threonine protein kinase
KWG62_RS12790	COG1162	GTPase activity
KWG62_RS12810	COG1028	Short-chain dehydrogenase reductase Sdr
KWG62_RS12815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KWG62_RS12825	COG2207	Transcriptional regulator
KWG62_RS12825	COG1917	Cupin 2, conserved barrel domain protein
KWG62_RS12830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KWG62_RS12845	COG0180	Tryptophanyl-tRNA synthetase
KWG62_RS12850	COG0574	Belongs to the PEP-utilizing enzyme family
KWG62_RS12850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KWG62_RS12880	COG1045	serine acetyltransferase
KWG62_RS12890	COG1263	PTS System
KWG62_RS12890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KWG62_RS12890	COG2190	(PTS) system
KWG62_RS12895	COG1609	Transcriptional regulator
KWG62_RS12905	COG0189	ligase activity
KWG62_RS12905	COG2918	glutathione biosynthetic process
KWG62_RS12915	COG0546	phosphoglycolate phosphatase activity
KWG62_RS12925	COG1691	(AIR) carboxylase