locus-tag	class	description
MIC7113_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MIC7113_RS00015	COG0592	DNA-directed DNA polymerase activity
MIC7113_RS00020	COG1672	PFAM Archaeal ATPase
MIC7113_RS00020	COG2319	Wd-40 repeat
MIC7113_RS00035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MIC7113_RS00040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MIC7113_RS00045	COG1830	Aldolase
MIC7113_RS00060	COG0436	Aminotransferase
MIC7113_RS00070	COG0589	response to stress
MIC7113_RS00080	COG1309	transcriptional regulator
MIC7113_RS00090	COG1610	YqeY-like protein
MIC7113_RS00095	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MIC7113_RS00100	COG1254	Belongs to the acylphosphatase family
MIC7113_RS00110	COG0697	spore germination
MIC7113_RS00115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MIC7113_RS00170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MIC7113_RS00175	COG0583	DNA-binding transcription factor activity
MIC7113_RS00185	COG0194	GDP metabolic process
MIC7113_RS00190	COG2052	Domain of unknown function (DUF370)
MIC7113_RS00205	COG1116	anion transmembrane transporter activity
MIC7113_RS00210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MIC7113_RS00230	COG0375	protein maturation
MIC7113_RS00235	COG0010	Belongs to the arginase family
MIC7113_RS00245	COG1122	ATPase activity
MIC7113_RS00250	COG0357	Ribosomal RNA small subunit methyltransferase G
MIC7113_RS00255	COG0667	Aldo Keto reductase
MIC7113_RS00260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MIC7113_RS00275	COG2183	response to ionizing radiation
MIC7113_RS00300	COG3386	PFAM SMP-30 Gluconolaconase
MIC7113_RS00310	COG0788	formyltetrahydrofolate deformylase activity
MIC7113_RS00325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MIC7113_RS00335	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
MIC7113_RS00340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MIC7113_RS00345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MIC7113_RS00350	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MIC7113_RS00355	COG1773	rubredoxin
MIC7113_RS00360	COG4447	cellulose binding
MIC7113_RS00385	COG0124	histidyl-tRNA synthetase
MIC7113_RS00410	COG1191	sigma factor activity
MIC7113_RS00425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MIC7113_RS00430	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MIC7113_RS00445	COG1501	Belongs to the glycosyl hydrolase 31 family
MIC7113_RS00450	COG0489	protein tyrosine kinase activity
MIC7113_RS00455	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS00465	COG1132	(ABC) transporter
MIC7113_RS00475	COG1216	Glycosyl transferase, family 2
MIC7113_RS00480	COG1216	Glycosyl transferase, family 2
MIC7113_RS00485	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS00520	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS00525	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS00550	COG0489	protein tyrosine kinase activity
MIC7113_RS00555	COG0772	Belongs to the SEDS family
MIC7113_RS00575	COG0475	glutathione-regulated potassium exporter activity
MIC7113_RS00575	COG0589	response to stress
MIC7113_RS00585	COG0525	valine-tRNA ligase activity
MIC7113_RS00590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MIC7113_RS00590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MIC7113_RS00605	COG0243	molybdopterin cofactor binding
MIC7113_RS00615	COG2223	nitrite transmembrane transporter activity
MIC7113_RS00620	COG1116	anion transmembrane transporter activity
MIC7113_RS00625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MIC7113_RS00625	COG1116	anion transmembrane transporter activity
MIC7113_RS00630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MIC7113_RS00635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MIC7113_RS00670	COG0730	response to heat
MIC7113_RS00690	COG0730	response to heat
MIC7113_RS00700	COG0824	Thioesterase
MIC7113_RS00705	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MIC7113_RS00715	COG0477	Major facilitator Superfamily
MIC7113_RS00720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MIC7113_RS00740	COG0667	Aldo Keto reductase
MIC7113_RS00770	COG4106	trans-aconitate 2-methyltransferase activity
MIC7113_RS00825	COG3264	Mechanosensitive ion channel
MIC7113_RS00825	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MIC7113_RS00840	COG0159	tryptophan synthase activity
MIC7113_RS00860	COG2226	methyltransferase
MIC7113_RS00880	COG5002	protein histidine kinase activity
MIC7113_RS00885	COG0515	serine threonine protein kinase
MIC7113_RS00890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MIC7113_RS00910	COG1253	flavin adenine dinucleotide binding
MIC7113_RS00920	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MIC7113_RS00925	COG0673	inositol 2-dehydrogenase activity
MIC7113_RS00940	COG1253	flavin adenine dinucleotide binding
MIC7113_RS00985	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS00990	COG0668	transmembrane transport
MIC7113_RS01015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MIC7113_RS01050	COG0454	-acetyltransferase
MIC7113_RS01065	COG2890	protein-(glutamine-N5) methyltransferase activity
MIC7113_RS01070	COG0009	L-threonylcarbamoyladenylate synthase
MIC7113_RS01075	COG2205	protein histidine kinase activity
MIC7113_RS01075	COG0784	Response regulator, receiver
MIC7113_RS01075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIC7113_RS01075	COG2198	Histidine kinase
MIC7113_RS01080	COG0045	succinate-CoA ligase (ADP-forming) activity
MIC7113_RS01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MIC7113_RS01080	COG1042	CoA-binding domain protein
MIC7113_RS01090	COG0113	porphobilinogen synthase activity
MIC7113_RS01095	COG2205	protein histidine kinase activity
MIC7113_RS01095	COG0784	Response regulator, receiver
MIC7113_RS01100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MIC7113_RS01105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MIC7113_RS01130	COG0701	Predicted permease
MIC7113_RS01145	COG3118	belongs to the thioredoxin family
MIC7113_RS01150	COG0516	GMP reductase activity
MIC7113_RS01155	COG1012	belongs to the aldehyde dehydrogenase family
MIC7113_RS01175	COG0038	chloride channel
MIC7113_RS01185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MIC7113_RS01190	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MIC7113_RS01225	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MIC7113_RS01235	COG0314	molybdopterin synthase activity
MIC7113_RS01245	COG0784	Response regulator, receiver
MIC7113_RS01250	COG0596	Alpha beta hydrolase
MIC7113_RS01255	COG2205	protein histidine kinase activity
MIC7113_RS01255	COG5002	protein histidine kinase activity
MIC7113_RS01255	COG0784	Response regulator, receiver
MIC7113_RS01260	COG4251	negative regulation of phosphorylation
MIC7113_RS01285	COG1160	GTP binding
MIC7113_RS01295	COG2205	protein histidine kinase activity
MIC7113_RS01305	COG4251	negative regulation of phosphorylation
MIC7113_RS01310	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MIC7113_RS01355	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MIC7113_RS01360	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MIC7113_RS01390	COG1309	transcriptional regulator
MIC7113_RS01420	COG1716	ATPase activity
MIC7113_RS01420	COG5001	Diguanylate cyclase
MIC7113_RS01430	COG0006	proline dipeptidase activity
MIC7113_RS01455	COG2197	response regulator
MIC7113_RS01495	COG2239	Acts as a magnesium transporter
MIC7113_RS01505	COG0386	Belongs to the glutathione peroxidase family
MIC7113_RS01520	COG0025	NhaP-type Na H and K H
MIC7113_RS01560	COG0180	Tryptophanyl-tRNA synthetase
MIC7113_RS01570	COG0521	Mo-molybdopterin cofactor biosynthetic process
MIC7113_RS01580	COG4935	Belongs to the peptidase S8 family
MIC7113_RS01580	COG1404	Belongs to the peptidase S8 family
MIC7113_RS01585	COG0793	Belongs to the peptidase S41A family
MIC7113_RS01600	COG3829	transcription factor binding
MIC7113_RS01605	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS01605	COG0515	serine threonine protein kinase
MIC7113_RS01615	COG1047	Peptidyl-prolyl cis-trans
MIC7113_RS01625	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MIC7113_RS01625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MIC7113_RS01630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MIC7113_RS01630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MIC7113_RS01635	COG0840	transmembrane signaling receptor activity
MIC7113_RS01635	COG2203	Gaf domain
MIC7113_RS01655	COG0392	lysyltransferase activity
MIC7113_RS01655	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MIC7113_RS01690	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS01690	COG0515	serine threonine protein kinase
MIC7113_RS01705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MIC7113_RS01715	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MIC7113_RS01720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MIC7113_RS01725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MIC7113_RS01740	COG1968	undecaprenyl-diphosphatase activity
MIC7113_RS01755	COG0321	lipoyl(octanoyl) transferase activity
MIC7113_RS01760	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MIC7113_RS01765	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS01775	COG1381	Involved in DNA repair and RecF pathway recombination
MIC7113_RS01780	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MIC7113_RS01785	COG0803	Belongs to the bacterial solute-binding protein 9 family
MIC7113_RS01790	COG1121	(ABC) transporter
MIC7113_RS01795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MIC7113_RS01815	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MIC7113_RS01830	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MIC7113_RS01870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MIC7113_RS01875	COG1234	tRNA 3'-trailer cleavage
MIC7113_RS01895	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MIC7113_RS01900	COG0577	efflux transmembrane transporter activity
MIC7113_RS01900	COG1136	(ABC) transporter
MIC7113_RS01940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MIC7113_RS01945	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MIC7113_RS01950	COG2080	2 iron, 2 sulfur cluster binding
MIC7113_RS02000	COG0625	glutathione transferase activity
MIC7113_RS02025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MIC7113_RS02030	COG0860	N-Acetylmuramoyl-L-alanine amidase
MIC7113_RS02030	COG3409	Peptidoglycan-binding domain 1 protein
MIC7113_RS02035	COG0457	Tetratricopeptide repeat
MIC7113_RS02035	COG0463	Glycosyl transferase, family 2
MIC7113_RS02075	COG1649	PFAM Uncharacterised BCR, COG1649
MIC7113_RS02115	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MIC7113_RS02125	COG0784	Response regulator, receiver
MIC7113_RS02125	COG2205	protein histidine kinase activity
MIC7113_RS02130	COG0824	Thioesterase
MIC7113_RS02140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MIC7113_RS02140	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MIC7113_RS02155	COG2119	membrane
MIC7113_RS02160	COG2119	membrane
MIC7113_RS02190	COG2319	Wd-40 repeat
MIC7113_RS02190	COG4249	Peptidase C14 caspase catalytic subunit p20
MIC7113_RS02230	COG1192	Involved in chromosome partitioning
MIC7113_RS02250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MIC7113_RS02250	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MIC7113_RS02265	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MIC7113_RS02295	COG1846	Transcriptional regulator
MIC7113_RS02300	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MIC7113_RS02325	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
MIC7113_RS02330	COG0800	Aldolase
MIC7113_RS02350	COG0463	Glycosyl transferase, family 2
MIC7113_RS02360	COG0668	transmembrane transport
MIC7113_RS02370	COG2912	Transglutaminase-like superfamily
MIC7113_RS02405	COG0859	PFAM glycosyl transferase family 9
MIC7113_RS02410	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MIC7113_RS02420	COG1515	deoxyribonuclease V activity
MIC7113_RS02440	COG3621	Patatin-like phospholipase
MIC7113_RS02445	COG3903	Transcriptional regulator
MIC7113_RS02445	COG2319	Wd-40 repeat
MIC7113_RS02490	COG2885	chlorophyll binding
MIC7113_RS02495	COG2885	chlorophyll binding
MIC7113_RS02525	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MIC7113_RS02535	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MIC7113_RS02540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MIC7113_RS02545	COG3118	belongs to the thioredoxin family
MIC7113_RS02555	COG0583	DNA-binding transcription factor activity
MIC7113_RS02560	COG0515	serine threonine protein kinase
MIC7113_RS02600	COG0531	amino acid
MIC7113_RS02640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MIC7113_RS02650	COG1316	TRANSCRIPTIONal
MIC7113_RS02655	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS02690	COG1741	Belongs to the pirin family
MIC7113_RS02695	COG1733	regulation of RNA biosynthetic process
MIC7113_RS02705	COG1994	Peptidase M50
MIC7113_RS02705	COG0517	IMP dehydrogenase activity
MIC7113_RS02735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MIC7113_RS02750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MIC7113_RS02780	COG1215	transferase activity, transferring glycosyl groups
MIC7113_RS02795	COG1216	Glycosyl transferase, family 2
MIC7113_RS02830	COG4178	(ABC) transporter
MIC7113_RS02850	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS02855	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MIC7113_RS02865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MIC7113_RS02875	COG0505	Belongs to the CarA family
MIC7113_RS02885	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MIC7113_RS02890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MIC7113_RS02900	COG0596	Alpha beta hydrolase
MIC7113_RS02960	COG2319	Wd-40 repeat
MIC7113_RS02960	COG3903	Transcriptional regulator
MIC7113_RS02965	COG0154	amidase activity
MIC7113_RS02970	COG0587	DNA-directed DNA polymerase activity
MIC7113_RS02995	COG3657	addiction module killer protein
MIC7113_RS03005	COG2337	Toxic component of a toxin-antitoxin (TA) module
MIC7113_RS03085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MIC7113_RS03105	COG0440	acetolactate synthase activity
MIC7113_RS03120	COG3659	wide pore channel activity
MIC7113_RS03130	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MIC7113_RS03160	COG0612	Peptidase, M16
MIC7113_RS03165	COG0612	Peptidase, M16
MIC7113_RS03185	COG3842	ATPase activity
MIC7113_RS03190	COG0210	DNA helicase
MIC7113_RS03220	COG0259	pyridoxamine-phosphate oxidase activity
MIC7113_RS03230	COG4399	Belongs to the UPF0754 family
MIC7113_RS03235	COG2226	methyltransferase
MIC7113_RS03240	COG2204	response regulator
MIC7113_RS03260	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MIC7113_RS03315	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MIC7113_RS03335	COG0811	peptide transport
MIC7113_RS03345	COG1032	radical SAM domain protein
MIC7113_RS03390	COG0495	leucyl-tRNA aminoacylation
MIC7113_RS03400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MIC7113_RS03420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MIC7113_RS03475	COG1376	ErfK ybiS ycfS ynhG family protein
MIC7113_RS03490	COG1473	amidohydrolase
MIC7113_RS03520	COG4294	response to UV
MIC7113_RS03535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MIC7113_RS03570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MIC7113_RS03590	COG0138	bifunctional purine biosynthesis protein purh
MIC7113_RS03600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MIC7113_RS03605	COG2267	carboxylic ester hydrolase activity
MIC7113_RS03625	COG1191	sigma factor activity
MIC7113_RS03630	COG0670	Belongs to the BI1 family
MIC7113_RS03640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MIC7113_RS03645	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MIC7113_RS03650	COG0512	Glutamine amidotransferase of anthranilate synthase
MIC7113_RS03650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MIC7113_RS03670	COG0006	proline dipeptidase activity
MIC7113_RS03680	COG3237	CsbD-like
MIC7113_RS03685	COG3609	addiction module antidote protein, CC2985 family
MIC7113_RS03715	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
MIC7113_RS03735	COG1606	tRNA processing
MIC7113_RS03740	COG4172	Belongs to the ABC transporter superfamily
MIC7113_RS03745	COG0542	response to heat
MIC7113_RS03765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MIC7113_RS03830	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MIC7113_RS03835	COG2211	Major facilitator Superfamily
MIC7113_RS03840	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS03890	COG2885	chlorophyll binding
MIC7113_RS03890	COG3047	cAMP biosynthetic process
MIC7113_RS03895	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MIC7113_RS03910	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MIC7113_RS03915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MIC7113_RS03980	COG0515	serine threonine protein kinase
MIC7113_RS03980	COG2815	serine threonine protein kinase
MIC7113_RS04055	COG0004	ammonium transporteR
MIC7113_RS04140	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MIC7113_RS04145	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS04155	COG1193	negative regulation of DNA recombination
MIC7113_RS04190	COG1748	Saccharopine dehydrogenase
MIC7113_RS04200	COG1459	type II secretion system
MIC7113_RS04210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MIC7113_RS04215	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MIC7113_RS04220	COG0443	Heat shock 70 kDa protein
MIC7113_RS04225	COG0484	heat shock protein binding
MIC7113_RS04235	COG1162	GTPase activity
MIC7113_RS04245	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS04250	COG0483	inositol monophosphate 1-phosphatase activity
MIC7113_RS04275	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MIC7113_RS04295	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS04295	COG2205	protein histidine kinase activity
MIC7113_RS04295	COG3292	Two component regulator propeller
MIC7113_RS04335	COG0515	serine threonine protein kinase
MIC7113_RS04335	COG3266	domain, Protein
MIC7113_RS04350	COG2911	Protein conserved in bacteria
MIC7113_RS04350	COG1361	Conserved repeat domain
MIC7113_RS04350	COG3266	domain, Protein
MIC7113_RS04355	COG1131	(ABC) transporter
MIC7113_RS04380	COG1185	polyribonucleotide nucleotidyltransferase activity
MIC7113_RS04385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MIC7113_RS04405	COG0123	including yeast histone deacetylase and acetoin utilization protein
MIC7113_RS04410	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MIC7113_RS04415	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MIC7113_RS04435	COG0450	alkyl hydroperoxide reductase
MIC7113_RS04440	COG2177	Part of the ABC transporter FtsEX involved in
MIC7113_RS04470	COG2166	iron-sulfur cluster assembly
MIC7113_RS04495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MIC7113_RS04515	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MIC7113_RS04540	COG0793	Belongs to the peptidase S41A family
MIC7113_RS04545	COG2319	Wd-40 repeat
MIC7113_RS04545	COG4249	Peptidase C14 caspase catalytic subunit p20
MIC7113_RS04560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MIC7113_RS04565	COG0351	phosphomethylpyrimidine kinase
MIC7113_RS04580	COG5002	protein histidine kinase activity
MIC7113_RS04590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MIC7113_RS04595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MIC7113_RS04600	COG2203	Gaf domain
MIC7113_RS04650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MIC7113_RS04680	COG3852	Histidine kinase
MIC7113_RS04700	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
MIC7113_RS04710	COG3237	CsbD-like
MIC7113_RS04725	COG0556	nucleotide-excision repair
MIC7113_RS04750	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
MIC7113_RS04760	COG0123	including yeast histone deacetylase and acetoin utilization protein
MIC7113_RS04765	COG0284	orotidine-5'-phosphate decarboxylase activity
MIC7113_RS04765	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MIC7113_RS04795	COG0789	Transcriptional regulator
MIC7113_RS04810	COG0686	Belongs to the AlaDH PNT family
MIC7113_RS04830	COG0724	RNA recognition motif
MIC7113_RS04835	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MIC7113_RS04840	COG2135	peptidase activity
MIC7113_RS04865	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MIC7113_RS04875	COG3937	granule-associated protein
MIC7113_RS04890	COG0672	)-iron permease
MIC7113_RS04910	COG2132	Multicopper oxidase
MIC7113_RS04920	COG2226	methyltransferase
MIC7113_RS04925	COG2720	vancomycin resistance protein
MIC7113_RS04930	COG1122	ATPase activity
MIC7113_RS04935	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MIC7113_RS04990	COG0515	serine threonine protein kinase
MIC7113_RS05000	COG2204	response regulator
MIC7113_RS05005	COG0784	Response regulator, receiver
MIC7113_RS05005	COG2205	protein histidine kinase activity
MIC7113_RS05010	COG0735	belongs to the Fur family
MIC7113_RS05015	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MIC7113_RS05020	COG1819	glycosyl
MIC7113_RS05025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MIC7113_RS05045	COG0581	inorganic phosphate transmembrane transporter activity
MIC7113_RS05050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MIC7113_RS05055	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS05090	COG1216	Glycosyl transferase, family 2
MIC7113_RS05095	COG2894	cell division
MIC7113_RS05115	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
MIC7113_RS05120	COG2884	Cell division ATP-binding protein ftsE
MIC7113_RS05190	COG0366	Alpha amylase catalytic
MIC7113_RS05195	COG0587	DNA-directed DNA polymerase activity
MIC7113_RS05225	COG0675	Transposase, IS605 OrfB family
MIC7113_RS05230	COG0336	Belongs to the RNA methyltransferase TrmD family
MIC7113_RS05235	COG4242	Belongs to the peptidase S51 family
MIC7113_RS05240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MIC7113_RS05240	COG0189	ligase activity
MIC7113_RS05245	COG3659	wide pore channel activity
MIC7113_RS05260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MIC7113_RS05285	COG1361	Conserved repeat domain
MIC7113_RS05310	COG0811	peptide transport
MIC7113_RS05335	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS05340	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MIC7113_RS05365	COG2201	protein-glutamate methylesterase activity
MIC7113_RS05375	COG1404	Belongs to the peptidase S8 family
MIC7113_RS05385	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MIC7113_RS05390	COG1131	(ABC) transporter
MIC7113_RS05410	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MIC7113_RS05430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MIC7113_RS05465	COG0135	phosphoribosylanthranilate isomerase activity
MIC7113_RS05480	COG1994	Peptidase M50
MIC7113_RS05480	COG0517	IMP dehydrogenase activity
MIC7113_RS05485	COG0095	Lipoate-protein ligase
MIC7113_RS05505	COG0174	glutamine synthetase
MIC7113_RS05520	COG0515	serine threonine protein kinase
MIC7113_RS05520	COG2815	serine threonine protein kinase
MIC7113_RS05555	COG4680	protein conserved in bacteria
MIC7113_RS05565	COG2814	Major facilitator Superfamily
MIC7113_RS05575	COG3185	4-Hydroxyphenylpyruvate dioxygenase
MIC7113_RS05595	COG0315	cyclic pyranopterin monophosphate synthase activity
MIC7113_RS05615	COG0728	peptidoglycan biosynthetic process
MIC7113_RS05630	COG1489	DNA binding
MIC7113_RS05635	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MIC7113_RS05645	COG1132	(ABC) transporter
MIC7113_RS05660	COG5001	Diguanylate cyclase
MIC7113_RS05660	COG1716	ATPase activity
MIC7113_RS05670	COG4106	trans-aconitate 2-methyltransferase activity
MIC7113_RS05675	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MIC7113_RS05680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MIC7113_RS05715	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MIC7113_RS05725	COG1950	PFAM Membrane protein of
MIC7113_RS05770	COG4636	protein conserved in cyanobacteria
MIC7113_RS05790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MIC7113_RS05790	COG1754	DNA topoisomerase type I activity
MIC7113_RS05800	COG0784	Response regulator, receiver
MIC7113_RS05800	COG2198	Histidine kinase
MIC7113_RS05800	COG5002	protein histidine kinase activity
MIC7113_RS05810	COG1007	ATP synthesis coupled electron transport
MIC7113_RS05825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MIC7113_RS05830	COG1408	metallophosphoesterase
MIC7113_RS05885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MIC7113_RS05925	COG1496	oxidoreductase activity
MIC7113_RS05930	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MIC7113_RS05930	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MIC7113_RS05935	COG0739	heme binding
MIC7113_RS05975	COG0784	Response regulator, receiver
MIC7113_RS05975	COG2205	protein histidine kinase activity
MIC7113_RS05975	COG5002	protein histidine kinase activity
MIC7113_RS05980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MIC7113_RS05985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MIC7113_RS05995	COG0860	N-Acetylmuramoyl-L-alanine amidase
MIC7113_RS06015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MIC7113_RS06030	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MIC7113_RS06035	COG0306	phosphate transporter
MIC7113_RS06045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MIC7113_RS06085	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
MIC7113_RS06090	COG0784	Response regulator, receiver
MIC7113_RS06105	COG2203	Gaf domain
MIC7113_RS06105	COG0840	transmembrane signaling receptor activity
MIC7113_RS06110	COG0784	Response regulator, receiver
MIC7113_RS06110	COG0643	Histidine kinase
MIC7113_RS06110	COG2198	Histidine kinase
MIC7113_RS06135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MIC7113_RS06145	COG0121	glutamine amidotransferase
MIC7113_RS06150	COG5635	Nacht domain
MIC7113_RS06150	COG2319	Wd-40 repeat
MIC7113_RS06160	COG4636	protein conserved in cyanobacteria
MIC7113_RS06165	COG2373	Large extracellular alpha-helical protein
MIC7113_RS06170	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MIC7113_RS06175	COG4149	molybdate abc transporter
MIC7113_RS06180	COG0725	ABC transporter, periplasmic molybdate-binding protein
MIC7113_RS06215	COG0316	Belongs to the HesB IscA family
MIC7113_RS06225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MIC7113_RS06235	COG5420	small protein containing a coiled-coil domain
MIC7113_RS06250	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MIC7113_RS06255	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MIC7113_RS06265	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MIC7113_RS06285	COG1104	cysteine desulfurase activity
MIC7113_RS06290	COG0535	radical SAM domain protein
MIC7113_RS06290	COG1433	Dinitrogenase iron-molybdenum cofactor
MIC7113_RS06295	COG1045	serine acetyltransferase
MIC7113_RS06305	COG0783	Belongs to the Dps family
MIC7113_RS06315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MIC7113_RS06320	COG5554	nitrogen fixation
MIC7113_RS06355	COG0347	Belongs to the P(II) protein family
MIC7113_RS06370	COG0402	S-adenosylhomocysteine deaminase activity
MIC7113_RS06375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MIC7113_RS06380	COG0596	Alpha beta hydrolase
MIC7113_RS06385	COG0515	serine threonine protein kinase
MIC7113_RS06390	COG0363	glucosamine-6-phosphate deaminase activity
MIC7113_RS06395	COG2223	nitrite transmembrane transporter activity
MIC7113_RS06450	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
MIC7113_RS06460	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MIC7113_RS06480	COG1882	Formate acetyltransferase
MIC7113_RS06485	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MIC7113_RS06490	COG1454	alcohol dehydrogenase
MIC7113_RS06490	COG1012	belongs to the aldehyde dehydrogenase family
MIC7113_RS06510	COG0735	belongs to the Fur family
MIC7113_RS06515	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MIC7113_RS06520	COG0047	phosphoribosylformylglycinamidine synthase activity
MIC7113_RS06530	COG2319	Wd-40 repeat
MIC7113_RS06535	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MIC7113_RS06545	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MIC7113_RS06550	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MIC7113_RS06560	COG1716	ATPase activity
MIC7113_RS06565	COG0363	glucosamine-6-phosphate deaminase activity
MIC7113_RS06580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MIC7113_RS06585	COG0552	protein localization to endoplasmic reticulum
MIC7113_RS06590	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS06595	COG4636	protein conserved in cyanobacteria
MIC7113_RS06610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MIC7113_RS06630	COG0632	four-way junction helicase activity
MIC7113_RS06635	COG0561	phosphatase activity
MIC7113_RS06640	COG2319	Wd-40 repeat
MIC7113_RS06640	COG4249	Peptidase C14 caspase catalytic subunit p20
MIC7113_RS06660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MIC7113_RS06665	COG0515	serine threonine protein kinase
MIC7113_RS06665	COG3266	domain, Protein
MIC7113_RS06685	COG3659	wide pore channel activity
MIC7113_RS06690	COG0640	Transcriptional regulator
MIC7113_RS06725	COG2082	Precorrin-8x methylmutase
MIC7113_RS06735	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MIC7113_RS06750	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MIC7113_RS06755	COG0187	DNA topoisomerase II activity
MIC7113_RS06755	COG1372	Participates in initiation and elongation during chromosome replication
MIC7113_RS06785	COG5398	heme oxygenase
MIC7113_RS06800	COG0222	ribosome binding
MIC7113_RS06805	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MIC7113_RS06810	COG0081	regulation of translation
MIC7113_RS06815	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MIC7113_RS06820	COG0250	Participates in transcription elongation, termination and antitermination
MIC7113_RS06825	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MIC7113_RS06835	COG0335	large ribosomal subunit rRNA binding
MIC7113_RS06840	COG3659	wide pore channel activity
MIC7113_RS06845	COG3659	wide pore channel activity
MIC7113_RS06850	COG3659	wide pore channel activity
MIC7113_RS06855	COG0704	Plays a role in the regulation of phosphate uptake
MIC7113_RS06860	COG5002	protein histidine kinase activity
MIC7113_RS06865	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS06870	COG1402	creatininase
MIC7113_RS06875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MIC7113_RS06880	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS06895	COG3239	Fatty acid desaturase
MIC7113_RS06905	COG0493	'glutamate synthase
MIC7113_RS06915	COG0070	glutamate synthase
MIC7113_RS06915	COG0067	glutamate synthase
MIC7113_RS06915	COG0069	glutamate synthase activity
MIC7113_RS06970	COG0616	signal peptide processing
MIC7113_RS06975	COG1304	FMN binding
MIC7113_RS06980	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MIC7113_RS06985	COG3409	Peptidoglycan-binding domain 1 protein
MIC7113_RS06985	COG3773	Cell wall hydrolase
MIC7113_RS06990	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MIC7113_RS06995	COG1959	2 iron, 2 sulfur cluster binding
MIC7113_RS07025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MIC7113_RS07035	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS07040	COG5002	protein histidine kinase activity
MIC7113_RS07045	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MIC7113_RS07060	COG0515	serine threonine protein kinase
MIC7113_RS07085	COG0537	adenosine 5'-monophosphoramidase activity
MIC7113_RS07090	COG0606	chelatase, subunit chli
MIC7113_RS07100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MIC7113_RS07105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MIC7113_RS07105	COG0574	Belongs to the PEP-utilizing enzyme family
MIC7113_RS07120	COG0484	heat shock protein binding
MIC7113_RS07125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MIC7113_RS07135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MIC7113_RS07150	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
MIC7113_RS07170	COG2852	Protein conserved in bacteria
MIC7113_RS07180	COG2084	Dehydrogenase
MIC7113_RS07185	COG0039	L-malate dehydrogenase activity
MIC7113_RS07205	COG2885	chlorophyll binding
MIC7113_RS07205	COG3047	cAMP biosynthetic process
MIC7113_RS07220	COG1187	pseudouridine synthase activity
MIC7113_RS07230	COG0515	serine threonine protein kinase
MIC7113_RS07230	COG3266	domain, Protein
MIC7113_RS07245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MIC7113_RS07265	COG4636	protein conserved in cyanobacteria
MIC7113_RS07270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MIC7113_RS07280	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS07290	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MIC7113_RS07295	COG0271	Belongs to the BolA IbaG family
MIC7113_RS07305	COG4935	Belongs to the peptidase S8 family
MIC7113_RS07305	COG1404	Belongs to the peptidase S8 family
MIC7113_RS07315	COG4689	acetoacetate decarboxylase
MIC7113_RS07335	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MIC7113_RS07350	COG1253	flavin adenine dinucleotide binding
MIC7113_RS07355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MIC7113_RS07360	COG0542	response to heat
MIC7113_RS07375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MIC7113_RS07385	COG0170	dolichyl monophosphate biosynthetic process
MIC7113_RS07390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MIC7113_RS07395	COG2197	response regulator
MIC7113_RS07410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MIC7113_RS07420	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
MIC7113_RS07455	COG2202	Pas domain
MIC7113_RS07455	COG2205	protein histidine kinase activity
MIC7113_RS07500	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MIC7113_RS07525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MIC7113_RS07530	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MIC7113_RS07545	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MIC7113_RS07570	COG4636	protein conserved in cyanobacteria
MIC7113_RS07590	COG0577	efflux transmembrane transporter activity
MIC7113_RS07590	COG1136	(ABC) transporter
MIC7113_RS07600	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MIC7113_RS07635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MIC7113_RS07655	COG1012	belongs to the aldehyde dehydrogenase family
MIC7113_RS07660	COG0237	dephospho-CoA kinase activity
MIC7113_RS07665	COG4636	protein conserved in cyanobacteria
MIC7113_RS07675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MIC7113_RS07720	COG3903	Transcriptional regulator
MIC7113_RS07720	COG2319	Wd-40 repeat
MIC7113_RS07735	COG5398	heme oxygenase
MIC7113_RS07740	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
MIC7113_RS07745	COG1192	Involved in chromosome partitioning
MIC7113_RS07755	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
MIC7113_RS07760	COG0501	Belongs to the peptidase M48B family
MIC7113_RS07775	COG4974	Belongs to the 'phage' integrase family
MIC7113_RS07790	COG0110	maltose O-acetyltransferase activity
MIC7113_RS07800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MIC7113_RS07805	COG1690	Belongs to the RtcB family
MIC7113_RS07810	COG2226	methyltransferase
MIC7113_RS07835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MIC7113_RS07835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MIC7113_RS07865	COG0515	serine threonine protein kinase
MIC7113_RS07865	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS07885	COG1077	Cell shape determining protein MreB Mrl
MIC7113_RS07890	COG0629	single-stranded DNA binding
MIC7113_RS07905	COG0475	glutathione-regulated potassium exporter activity
MIC7113_RS07915	COG0860	N-Acetylmuramoyl-L-alanine amidase
MIC7113_RS07920	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MIC7113_RS07930	COG0142	geranyltranstransferase activity
MIC7113_RS07965	COG0398	Pfam SNARE associated Golgi protein
MIC7113_RS07980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MIC7113_RS07990	COG0573	inorganic phosphate transmembrane transporter activity
MIC7113_RS07995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MIC7113_RS08035	COG0848	biopolymer transport protein
MIC7113_RS08040	COG0811	peptide transport
MIC7113_RS08045	COG4771	TonB-dependent receptor
MIC7113_RS08065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MIC7113_RS08070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MIC7113_RS08075	COG1120	ATPase activity
MIC7113_RS08100	COG0640	Transcriptional regulator
MIC7113_RS08105	COG2226	methyltransferase
MIC7113_RS08115	COG0515	serine threonine protein kinase
MIC7113_RS08125	COG3292	Two component regulator propeller
MIC7113_RS08125	COG2205	protein histidine kinase activity
MIC7113_RS08125	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS08150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MIC7113_RS08155	COG0798	PFAM Bile acid sodium symporter
MIC7113_RS08160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MIC7113_RS08165	COG0640	Transcriptional regulator
MIC7113_RS08180	COG5002	protein histidine kinase activity
MIC7113_RS08185	COG0784	Response regulator, receiver
MIC7113_RS08200	COG0484	heat shock protein binding
MIC7113_RS08210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MIC7113_RS08230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MIC7113_RS08315	COG0352	thiamine-phosphate diphosphorylase activity
MIC7113_RS08330	COG3852	Histidine kinase
MIC7113_RS08335	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS08340	COG2205	protein histidine kinase activity
MIC7113_RS08345	COG2875	Belongs to the precorrin methyltransferase family
MIC7113_RS08405	COG2197	response regulator
MIC7113_RS08430	COG1266	CAAX protease self-immunity
MIC7113_RS08455	COG2319	Wd-40 repeat
MIC7113_RS08455	COG1672	PFAM Archaeal ATPase
MIC7113_RS08470	COG2124	cytochrome p450
MIC7113_RS08485	COG0076	glutamate decarboxylase activity
MIC7113_RS08505	COG1960	acyl-CoA dehydrogenase activity
MIC7113_RS08515	COG1250	3-hydroxyacyl-CoA dehydrogenase
MIC7113_RS08530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MIC7113_RS08535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MIC7113_RS08540	COG0736	holo-[acyl-carrier-protein] synthase activity
MIC7113_RS08555	COG0736	holo-[acyl-carrier-protein] synthase activity
MIC7113_RS08565	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MIC7113_RS08575	COG2217	Heavy metal translocating P-type atpase
MIC7113_RS08620	COG2198	Histidine kinase
MIC7113_RS08620	COG2205	protein histidine kinase activity
MIC7113_RS08620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIC7113_RS08620	COG0784	Response regulator, receiver
MIC7113_RS08625	COG1028	Short-chain dehydrogenase reductase Sdr
MIC7113_RS08645	COG2319	Wd-40 repeat
MIC7113_RS08645	COG3903	Transcriptional regulator
MIC7113_RS08655	COG0514	ATP-dependent DNA helicase (RecQ)
MIC7113_RS08675	COG2319	Wd-40 repeat
MIC7113_RS08675	COG1672	PFAM Archaeal ATPase
MIC7113_RS08725	COG1028	Short-chain dehydrogenase reductase Sdr
MIC7113_RS08750	COG1040	competence protein
MIC7113_RS08775	COG1266	CAAX protease self-immunity
MIC7113_RS08795	COG2076	Multidrug Resistance protein
MIC7113_RS08805	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MIC7113_RS08810	COG0697	spore germination
MIC7113_RS08825	COG1446	asparaginase
MIC7113_RS08840	COG1196	nuclear chromosome segregation
MIC7113_RS08855	COG1595	DNA-templated transcription, initiation
MIC7113_RS08870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MIC7113_RS08875	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MIC7113_RS08880	COG2319	Wd-40 repeat
MIC7113_RS08880	COG3903	Transcriptional regulator
MIC7113_RS08885	COG2205	protein histidine kinase activity
MIC7113_RS08890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MIC7113_RS08895	COG0435	Glutathione S-transferase
MIC7113_RS08900	COG0649	NAD binding
MIC7113_RS08905	COG2124	cytochrome p450
MIC7113_RS08915	COG0390	transport system, permease component
MIC7113_RS08935	COG0515	serine threonine protein kinase
MIC7113_RS08935	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS08945	COG3239	Fatty acid desaturase
MIC7113_RS09015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MIC7113_RS09020	COG2205	protein histidine kinase activity
MIC7113_RS09030	COG0489	protein tyrosine kinase activity
MIC7113_RS09045	COG2226	methyltransferase
MIC7113_RS09055	COG1215	transferase activity, transferring glycosyl groups
MIC7113_RS09080	COG0726	polysaccharide deacetylase
MIC7113_RS09095	COG0628	permease
MIC7113_RS09115	COG0628	permease
MIC7113_RS09125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MIC7113_RS09130	COG0631	protein serine/threonine phosphatase activity
MIC7113_RS09135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MIC7113_RS09140	COG3937	granule-associated protein
MIC7113_RS09155	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MIC7113_RS09155	COG0517	IMP dehydrogenase activity
MIC7113_RS09155	COG0617	tRNA 3'-terminal CCA addition
MIC7113_RS09165	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MIC7113_RS09180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MIC7113_RS09190	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MIC7113_RS09215	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS09215	COG0515	serine threonine protein kinase
MIC7113_RS09240	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MIC7113_RS09250	COG2198	Histidine kinase
MIC7113_RS09250	COG0784	Response regulator, receiver
MIC7113_RS09250	COG0643	Histidine kinase
MIC7113_RS09255	COG0840	transmembrane signaling receptor activity
MIC7113_RS09255	COG2203	Gaf domain
MIC7113_RS09275	COG0830	nickel cation binding
MIC7113_RS09280	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MIC7113_RS09305	COG2082	Precorrin-8x methylmutase
MIC7113_RS09320	COG0439	Biotin carboxylase
MIC7113_RS09330	COG0515	serine threonine protein kinase
MIC7113_RS09345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MIC7113_RS09355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MIC7113_RS09420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MIC7113_RS09450	COG1429	ligase activity, forming nitrogen-metal bonds
MIC7113_RS09505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MIC7113_RS09510	COG0431	NADPH-dependent FMN reductase
MIC7113_RS09535	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MIC7113_RS09545	COG0330	HflC and HflK could
MIC7113_RS09590	COG2124	cytochrome p450
MIC7113_RS09595	COG1032	radical SAM domain protein
MIC7113_RS09610	COG4638	Rieske (2fe-2S)
MIC7113_RS09615	COG0156	8-amino-7-oxononanoate synthase activity
MIC7113_RS09650	COG0861	Integral membrane protein TerC family
MIC7113_RS09655	COG0105	UTP biosynthetic process
MIC7113_RS09660	COG1181	Belongs to the D-alanine--D-alanine ligase family
MIC7113_RS09670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MIC7113_RS09675	COG3668	Plasmid stabilization system
MIC7113_RS09700	COG0509	glycine decarboxylation via glycine cleavage system
MIC7113_RS09735	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MIC7113_RS09740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MIC7113_RS09740	COG0574	Belongs to the PEP-utilizing enzyme family
MIC7113_RS09750	COG0316	Belongs to the HesB IscA family
MIC7113_RS09795	COG0561	phosphatase activity
MIC7113_RS09805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MIC7113_RS09810	COG0432	Pfam Uncharacterised protein family UPF0047
MIC7113_RS09830	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS10005	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
MIC7113_RS10070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MIC7113_RS10090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MIC7113_RS10110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MIC7113_RS10120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MIC7113_RS10125	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MIC7113_RS10135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MIC7113_RS10140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MIC7113_RS10145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MIC7113_RS10150	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MIC7113_RS10165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MIC7113_RS10170	COG0511	ligase activity, forming carbon-carbon bonds
MIC7113_RS10175	COG0640	Transcriptional regulator
MIC7113_RS10195	COG0442	prolyl-tRNA aminoacylation
MIC7113_RS10200	COG2154	pterin-4-alpha-carbinolamine dehydratase
MIC7113_RS10230	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MIC7113_RS10250	COG1285	pathogenesis
MIC7113_RS10270	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MIC7113_RS10345	COG1473	amidohydrolase
MIC7113_RS10345	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MIC7113_RS10395	COG1575	Belongs to the MenA family. Type 1 subfamily
MIC7113_RS10400	COG4948	Mandelate Racemase Muconate Lactonizing
MIC7113_RS10405	COG0318	PFAM AMP-dependent synthetase and ligase
MIC7113_RS10425	COG0667	Aldo Keto reductase
MIC7113_RS10435	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS10465	COG0432	Pfam Uncharacterised protein family UPF0047
MIC7113_RS10475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MIC7113_RS10505	COG4372	Transposase
MIC7113_RS10510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MIC7113_RS10515	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MIC7113_RS10520	COG0131	Imidazoleglycerol-phosphate dehydratase
MIC7113_RS10525	COG3903	Transcriptional regulator
MIC7113_RS10525	COG2319	Wd-40 repeat
MIC7113_RS10565	COG0542	response to heat
MIC7113_RS10585	COG0330	HflC and HflK could
MIC7113_RS10590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MIC7113_RS10595	COG0149	triose-phosphate isomerase activity
MIC7113_RS10615	COG1070	Carbohydrate kinase
MIC7113_RS10650	COG0235	Class ii aldolase
MIC7113_RS10655	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
MIC7113_RS10675	COG2198	Histidine kinase
MIC7113_RS10675	COG0784	Response regulator, receiver
MIC7113_RS10675	COG2205	protein histidine kinase activity
MIC7113_RS10705	COG0484	heat shock protein binding
MIC7113_RS10740	COG1401	restriction endodeoxyribonuclease activity
MIC7113_RS10745	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MIC7113_RS10750	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MIC7113_RS10755	COG0483	inositol monophosphate 1-phosphatase activity
MIC7113_RS10760	COG0628	permease
MIC7113_RS10765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MIC7113_RS10770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MIC7113_RS10790	COG3706	GGDEF domain
MIC7113_RS10790	COG4251	negative regulation of phosphorylation
MIC7113_RS10790	COG5001	Diguanylate cyclase
MIC7113_RS10790	COG2203	Gaf domain
MIC7113_RS10840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MIC7113_RS10860	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS10865	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS10870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MIC7113_RS10880	COG0668	transmembrane transport
MIC7113_RS10930	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MIC7113_RS10930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MIC7113_RS10940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MIC7113_RS10945	COG0129	dihydroxy-acid dehydratase activity
MIC7113_RS10965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MIC7113_RS11005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MIC7113_RS11010	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MIC7113_RS11015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MIC7113_RS11020	COG2205	protein histidine kinase activity
MIC7113_RS11025	COG0148	phosphopyruvate hydratase activity
MIC7113_RS11030	COG0346	lactoylglutathione lyase activity
MIC7113_RS11035	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
MIC7113_RS11040	COG1028	Short-chain dehydrogenase reductase Sdr
MIC7113_RS11045	COG4221	oxidoreductase activity
MIC7113_RS11050	COG0492	ferredoxin-NADP+ reductase activity
MIC7113_RS11055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MIC7113_RS11065	COG0697	spore germination
MIC7113_RS11075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MIC7113_RS11085	COG0483	inositol monophosphate 1-phosphatase activity
MIC7113_RS11090	COG0484	heat shock protein binding
MIC7113_RS11095	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MIC7113_RS11100	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS11100	COG0515	serine threonine protein kinase
MIC7113_RS11120	COG0752	glycyl-tRNA synthetase alpha subunit
MIC7113_RS11150	COG0193	aminoacyl-tRNA hydrolase activity
MIC7113_RS11155	COG1672	PFAM Archaeal ATPase
MIC7113_RS11160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MIC7113_RS11235	COG3240	lipase activity
MIC7113_RS11245	COG0681	Belongs to the peptidase S26 family
MIC7113_RS11255	COG0284	orotidine-5'-phosphate decarboxylase activity
MIC7113_RS11260	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MIC7113_RS11265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MIC7113_RS11300	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MIC7113_RS11310	COG1850	ribulose-bisphosphate carboxylase activity
MIC7113_RS11320	COG4451	ribulose bisphosphate carboxylase, small
MIC7113_RS11330	COG4451	ribulose bisphosphate carboxylase, small
MIC7113_RS11330	COG0464	growth
MIC7113_RS11350	COG1222	aaa ATPase
MIC7113_RS11370	COG3266	domain, Protein
MIC7113_RS11370	COG0515	serine threonine protein kinase
MIC7113_RS11375	COG0484	heat shock protein binding
MIC7113_RS11380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MIC7113_RS11420	COG0287	Prephenate dehydrogenase
MIC7113_RS11425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MIC7113_RS11430	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MIC7113_RS11435	COG3128	pkhd-type hydroxylase
MIC7113_RS11445	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MIC7113_RS11450	COG0443	Heat shock 70 kDa protein
MIC7113_RS11465	COG0318	PFAM AMP-dependent synthetase and ligase
MIC7113_RS11470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MIC7113_RS11485	COG2091	lysine biosynthetic process via aminoadipic acid
MIC7113_RS11515	COG2319	Wd-40 repeat
MIC7113_RS11515	COG3903	Transcriptional regulator
MIC7113_RS11520	COG1403	HNH endonuclease
MIC7113_RS11525	COG0561	phosphatase activity
MIC7113_RS11535	COG0783	Belongs to the Dps family
MIC7113_RS11545	COG0783	Belongs to the Dps family
MIC7113_RS11555	COG1505	serine-type exopeptidase activity
MIC7113_RS11570	COG0557	exoribonuclease II activity
MIC7113_RS11575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MIC7113_RS11585	COG0303	'Molybdopterin
MIC7113_RS11590	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS11590	COG0515	serine threonine protein kinase
MIC7113_RS11595	COG0072	phenylalanine-tRNA ligase activity
MIC7113_RS11595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MIC7113_RS11605	COG0515	serine threonine protein kinase
MIC7113_RS11610	COG0515	serine threonine protein kinase
MIC7113_RS11610	COG3266	domain, Protein
MIC7113_RS11615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MIC7113_RS11625	COG3546	catalase activity
MIC7113_RS11630	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS11630	COG0515	serine threonine protein kinase
MIC7113_RS11645	COG2203	Gaf domain
MIC7113_RS11645	COG3706	GGDEF domain
MIC7113_RS11645	COG4251	negative regulation of phosphorylation
MIC7113_RS11645	COG5001	Diguanylate cyclase
MIC7113_RS11655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MIC7113_RS11670	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS11720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MIC7113_RS11730	COG0312	modulator of DNA gyrase
MIC7113_RS11765	COG5592	hemerythrin HHE cation binding domain
MIC7113_RS11775	COG2205	protein histidine kinase activity
MIC7113_RS11775	COG2198	Histidine kinase
MIC7113_RS11775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIC7113_RS11775	COG0784	Response regulator, receiver
MIC7113_RS11825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MIC7113_RS11845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MIC7113_RS11845	COG2022	thiamine diphosphate biosynthetic process
MIC7113_RS11855	COG0784	Response regulator, receiver
MIC7113_RS11865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MIC7113_RS11870	COG4245	von Willebrand factor, type A
MIC7113_RS11890	COG0596	Alpha beta hydrolase
MIC7113_RS11930	COG0288	reversible hydration of carbon dioxide
MIC7113_RS11935	COG0277	FAD linked oxidase domain protein
MIC7113_RS11960	COG1333	cytochrome c biogenesis protein
MIC7113_RS11970	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MIC7113_RS11985	COG0312	modulator of DNA gyrase
MIC7113_RS12005	COG3903	Transcriptional regulator
MIC7113_RS12005	COG2319	Wd-40 repeat
MIC7113_RS12045	COG2319	Wd-40 repeat
MIC7113_RS12045	COG1672	PFAM Archaeal ATPase
MIC7113_RS12070	COG0653	protein targeting
MIC7113_RS12140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MIC7113_RS12150	COG0693	protein deglycase activity
MIC7113_RS12155	COG0157	Belongs to the NadC ModD family
MIC7113_RS12185	COG1028	Short-chain dehydrogenase reductase Sdr
MIC7113_RS12190	COG1028	Short-chain dehydrogenase reductase Sdr
MIC7113_RS12220	COG3655	Transcriptional regulator
MIC7113_RS12225	COG0534	Mate efflux family protein
MIC7113_RS12245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MIC7113_RS12255	COG0515	serine threonine protein kinase
MIC7113_RS12285	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MIC7113_RS12285	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MIC7113_RS12300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MIC7113_RS12305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MIC7113_RS12305	COG1116	anion transmembrane transporter activity
MIC7113_RS12310	COG1116	anion transmembrane transporter activity
MIC7113_RS12340	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MIC7113_RS12345	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MIC7113_RS12365	COG0110	maltose O-acetyltransferase activity
MIC7113_RS12410	COG1215	transferase activity, transferring glycosyl groups
MIC7113_RS12480	COG0564	pseudouridine synthase activity
MIC7113_RS12485	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MIC7113_RS12525	COG0237	dephospho-CoA kinase activity
MIC7113_RS12530	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MIC7113_RS12535	COG1413	lyase activity
MIC7113_RS12570	COG0513	Belongs to the DEAD box helicase family
MIC7113_RS12580	COG1476	TRANSCRIPTIONal
MIC7113_RS12710	COG4636	protein conserved in cyanobacteria
MIC7113_RS12745	COG2264	protein methyltransferase activity
MIC7113_RS12750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MIC7113_RS12775	COG0515	serine threonine protein kinase
MIC7113_RS12775	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS12800	COG0469	pyruvate kinase activity
MIC7113_RS12840	COG1872	DUF167
MIC7113_RS12845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MIC7113_RS12850	COG1132	(ABC) transporter
MIC7113_RS12855	COG0300	oxidoreductase activity
MIC7113_RS12865	COG1028	Short-chain dehydrogenase reductase Sdr
MIC7113_RS12875	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MIC7113_RS12960	COG0501	Belongs to the peptidase M48B family
MIC7113_RS12985	COG1012	belongs to the aldehyde dehydrogenase family
MIC7113_RS13005	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MIC7113_RS13040	COG5002	protein histidine kinase activity
MIC7113_RS13065	COG0724	RNA recognition motif
MIC7113_RS13070	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MIC7113_RS13080	COG1562	ergosterol biosynthetic process
MIC7113_RS13085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MIC7113_RS13085	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
MIC7113_RS13095	COG2201	protein-glutamate methylesterase activity
MIC7113_RS13110	COG0835	chemotaxis
MIC7113_RS13125	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MIC7113_RS13140	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MIC7113_RS13170	COG4948	Mandelate Racemase Muconate Lactonizing
MIC7113_RS13175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MIC7113_RS13190	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MIC7113_RS13205	COG1063	alcohol dehydrogenase
MIC7113_RS13210	COG2202	Pas domain
MIC7113_RS13210	COG2205	protein histidine kinase activity
MIC7113_RS13220	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MIC7113_RS13225	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS13240	COG2267	carboxylic ester hydrolase activity
MIC7113_RS13275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MIC7113_RS13280	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MIC7113_RS13325	COG0411	ABC transporter
MIC7113_RS13355	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS13360	COG0829	nickel cation binding
MIC7113_RS13365	COG0831	urea catabolic process
MIC7113_RS13375	COG0832	Belongs to the urease beta subunit family
MIC7113_RS13395	COG0804	urea catabolic process
MIC7113_RS13405	COG1653	transport
MIC7113_RS13415	COG0395	ABC-type sugar transport system, permease component
MIC7113_RS13420	COG3264	Mechanosensitive ion channel
MIC7113_RS13420	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MIC7113_RS13425	COG1316	TRANSCRIPTIONal
MIC7113_RS13460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MIC7113_RS13485	COG0584	glycerophosphoryl diester phosphodiesterase
MIC7113_RS13495	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MIC7113_RS13510	COG0430	RNA-3'-phosphate cyclase activity
MIC7113_RS13540	COG0484	heat shock protein binding
MIC7113_RS13550	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MIC7113_RS13555	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MIC7113_RS13565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MIC7113_RS13575	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MIC7113_RS13585	COG1672	PFAM Archaeal ATPase
MIC7113_RS13585	COG2319	Wd-40 repeat
MIC7113_RS13590	COG1672	PFAM Archaeal ATPase
MIC7113_RS13590	COG2319	Wd-40 repeat
MIC7113_RS13595	COG2319	Wd-40 repeat
MIC7113_RS13595	COG1672	PFAM Archaeal ATPase
MIC7113_RS13635	COG0714	Associated with various cellular activities
MIC7113_RS13650	COG2319	Wd-40 repeat
MIC7113_RS13650	COG3903	Transcriptional regulator
MIC7113_RS13680	COG4251	negative regulation of phosphorylation
MIC7113_RS13700	COG0167	dihydroorotate dehydrogenase activity
MIC7113_RS13705	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS13735	COG0646	methionine synthase
MIC7113_RS13735	COG1410	methionine synthase
MIC7113_RS13760	COG1473	amidohydrolase
MIC7113_RS13765	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MIC7113_RS13770	COG0515	serine threonine protein kinase
MIC7113_RS13770	COG3266	domain, Protein
MIC7113_RS13775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MIC7113_RS13815	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MIC7113_RS13820	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MIC7113_RS13825	COG2376	Dihydroxyacetone kinase
MIC7113_RS13835	COG0270	DNA (cytosine-5-)-methyltransferase activity
MIC7113_RS13870	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MIC7113_RS13885	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
MIC7113_RS13890	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MIC7113_RS13895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MIC7113_RS13915	COG0589	response to stress
MIC7113_RS13925	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MIC7113_RS13955	COG3659	wide pore channel activity
MIC7113_RS13960	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
MIC7113_RS13970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MIC7113_RS13985	COG5001	Diguanylate cyclase
MIC7113_RS13985	COG4251	negative regulation of phosphorylation
MIC7113_RS13985	COG3706	GGDEF domain
MIC7113_RS13985	COG2203	Gaf domain
MIC7113_RS14005	COG0463	Glycosyl transferase, family 2
MIC7113_RS14020	COG1091	dTDP-4-dehydrorhamnose reductase activity
MIC7113_RS14030	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MIC7113_RS14030	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MIC7113_RS14050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MIC7113_RS14060	COG2124	cytochrome p450
MIC7113_RS14065	COG3956	TIGRFAM MazG family protein
MIC7113_RS14080	COG1959	2 iron, 2 sulfur cluster binding
MIC7113_RS14080	COG1295	ribonuclease BN
MIC7113_RS14090	COG5002	protein histidine kinase activity
MIC7113_RS14100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MIC7113_RS14145	COG4251	negative regulation of phosphorylation
MIC7113_RS14150	COG2129	metallophosphoesterase
MIC7113_RS14160	COG1253	flavin adenine dinucleotide binding
MIC7113_RS14165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MIC7113_RS14195	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MIC7113_RS14205	COG0025	NhaP-type Na H and K H
MIC7113_RS14215	COG3437	response regulator, receiver
MIC7113_RS14220	COG5002	protein histidine kinase activity
MIC7113_RS14220	COG0784	Response regulator, receiver
MIC7113_RS14225	COG2205	protein histidine kinase activity
MIC7113_RS14225	COG0784	Response regulator, receiver
MIC7113_RS14230	COG0435	Glutathione S-transferase
MIC7113_RS14235	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MIC7113_RS14240	COG0457	Tetratricopeptide repeat
MIC7113_RS14255	COG2255	four-way junction helicase activity
MIC7113_RS14260	COG0107	imidazoleglycerol-phosphate synthase activity
MIC7113_RS14285	COG2385	sporulation resulting in formation of a cellular spore
MIC7113_RS14285	COG2247	cell wall binding repeat
MIC7113_RS14300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MIC7113_RS14325	COG0297	glycogen (starch) synthase activity
MIC7113_RS14365	COG2124	cytochrome p450
MIC7113_RS14370	COG2124	cytochrome p450
MIC7113_RS14380	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS14385	COG1366	Belongs to the anti-sigma-factor antagonist family
MIC7113_RS14400	COG2205	protein histidine kinase activity
MIC7113_RS14430	COG3629	intracellular signal transduction
MIC7113_RS14430	COG3903	Transcriptional regulator
MIC7113_RS14450	COG3659	wide pore channel activity
MIC7113_RS14515	COG3659	wide pore channel activity
MIC7113_RS14530	COG0113	porphobilinogen synthase activity
MIC7113_RS14540	COG1121	(ABC) transporter
MIC7113_RS14545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MIC7113_RS14565	COG0523	cobalamin synthesis protein
MIC7113_RS14570	COG0302	gtp cyclohydrolase
MIC7113_RS14575	COG0523	cobalamin synthesis protein
MIC7113_RS14590	COG4451	ribulose bisphosphate carboxylase, small
MIC7113_RS14590	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MIC7113_RS14595	COG0215	cysteine-tRNA ligase activity
MIC7113_RS14620	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MIC7113_RS14630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MIC7113_RS14710	COG1845	cytochrome c oxidase, subunit III
MIC7113_RS14785	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MIC7113_RS14790	COG3259	Nickel-dependent hydrogenase
MIC7113_RS14805	COG0375	protein maturation
MIC7113_RS14810	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MIC7113_RS14815	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MIC7113_RS14820	COG0298	carbon dioxide binding
MIC7113_RS14830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MIC7113_RS14830	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MIC7113_RS14830	COG1013	pyruvate-flavodoxin oxidoreductase activity
MIC7113_RS14830	COG0674	pyruvate-flavodoxin oxidoreductase activity
MIC7113_RS14850	COG0205	6-phosphofructokinase activity
MIC7113_RS14860	COG4941	Belongs to the sigma-70 factor family
MIC7113_RS14865	COG3795	YCII-related domain
MIC7113_RS14900	COG3848	Pyruvate phosphate dikinase
MIC7113_RS14900	COG0574	Belongs to the PEP-utilizing enzyme family
MIC7113_RS14915	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS14920	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS14935	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS14965	COG0501	Belongs to the peptidase M48B family
MIC7113_RS14975	COG2010	Cytochrome c
MIC7113_RS14985	COG4771	TonB-dependent receptor
MIC7113_RS14990	COG2807	transmembrane transport
MIC7113_RS15010	COG1132	(ABC) transporter
MIC7113_RS15020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MIC7113_RS15055	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MIC7113_RS15125	COG0523	cobalamin synthesis protein
MIC7113_RS15140	COG1136	(ABC) transporter
MIC7113_RS15160	COG0515	serine threonine protein kinase
MIC7113_RS15160	COG2815	serine threonine protein kinase
MIC7113_RS15165	COG0626	cystathionine gamma-synthase activity
MIC7113_RS15175	COG5634	Uncharacterized conserved protein (DUF2278)
MIC7113_RS15180	COG1691	(AIR) carboxylase
MIC7113_RS15190	COG0747	negative chemotaxis
MIC7113_RS15230	COG1136	(ABC) transporter
MIC7113_RS15255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MIC7113_RS15260	COG1028	Short-chain dehydrogenase reductase Sdr
MIC7113_RS15275	COG0613	PHP domain protein
MIC7113_RS15300	COG4636	protein conserved in cyanobacteria
MIC7113_RS15350	COG0508	dehydrogenase complex catalyzes the overall conversion of
MIC7113_RS15380	COG1022	Amp-dependent synthetase and ligase
MIC7113_RS15395	COG1051	belongs to the nudix hydrolase family
MIC7113_RS15405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MIC7113_RS15440	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MIC7113_RS15465	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MIC7113_RS15480	COG3118	belongs to the thioredoxin family
MIC7113_RS15490	COG0312	modulator of DNA gyrase
MIC7113_RS15530	COG0463	Glycosyl transferase, family 2
MIC7113_RS15555	COG0156	8-amino-7-oxononanoate synthase activity
MIC7113_RS15570	COG0772	Belongs to the SEDS family
MIC7113_RS15590	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MIC7113_RS15590	COG0237	dephospho-CoA kinase activity
MIC7113_RS15595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MIC7113_RS15615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MIC7113_RS15620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MIC7113_RS15625	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MIC7113_RS15630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MIC7113_RS15635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MIC7113_RS15640	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MIC7113_RS15645	COG0356	it plays a direct role in the translocation of protons across the membrane
MIC7113_RS15655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MIC7113_RS15670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MIC7113_RS15680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MIC7113_RS15685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MIC7113_RS15710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MIC7113_RS15715	COG0003	Pfam Anion-transporting ATPase
MIC7113_RS15835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MIC7113_RS15845	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MIC7113_RS15900	COG0166	Belongs to the GPI family
MIC7113_RS15905	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS15910	COG2205	protein histidine kinase activity
MIC7113_RS15970	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MIC7113_RS15975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MIC7113_RS15985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MIC7113_RS15990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MIC7113_RS15995	COG2223	nitrite transmembrane transporter activity
MIC7113_RS16040	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MIC7113_RS16045	COG2894	cell division
MIC7113_RS16050	COG0850	regulation of cytokinetic process
MIC7113_RS16085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MIC7113_RS16100	COG3903	Transcriptional regulator
MIC7113_RS16100	COG2319	Wd-40 repeat
MIC7113_RS16110	COG4603	Belongs to the binding-protein-dependent transport system permease family
MIC7113_RS16115	COG1079	Belongs to the binding-protein-dependent transport system permease family
MIC7113_RS16130	COG3845	ABC transporter
MIC7113_RS16140	COG1335	isochorismatase
MIC7113_RS16145	COG3659	wide pore channel activity
MIC7113_RS16165	COG1404	Belongs to the peptidase S8 family
MIC7113_RS16170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MIC7113_RS16185	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MIC7113_RS16190	COG1518	maintenance of DNA repeat elements
MIC7113_RS16195	COG1468	defense response to virus
MIC7113_RS16195	COG1518	maintenance of DNA repeat elements
MIC7113_RS16235	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS16235	COG0515	serine threonine protein kinase
MIC7113_RS16245	COG0133	tryptophan synthase activity
MIC7113_RS16255	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MIC7113_RS16265	COG0784	Response regulator, receiver
MIC7113_RS16265	COG2205	protein histidine kinase activity
MIC7113_RS16280	COG1653	transport
MIC7113_RS16285	COG1175	transmembrane transport
MIC7113_RS16295	COG3842	ATPase activity
MIC7113_RS16305	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS16315	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS16320	COG3659	wide pore channel activity
MIC7113_RS16325	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
MIC7113_RS16355	COG2095	MarC family integral membrane protein
MIC7113_RS16420	COG0463	Glycosyl transferase, family 2
MIC7113_RS16430	COG0515	serine threonine protein kinase
MIC7113_RS16440	COG0784	Response regulator, receiver
MIC7113_RS16440	COG2205	protein histidine kinase activity
MIC7113_RS16450	COG0482	sulfurtransferase activity
MIC7113_RS16455	COG2046	Belongs to the sulfate adenylyltransferase family
MIC7113_RS16475	COG2326	polyphosphate kinase activity
MIC7113_RS16500	COG1361	Conserved repeat domain
MIC7113_RS16510	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MIC7113_RS16540	COG0129	dihydroxy-acid dehydratase activity
MIC7113_RS16560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MIC7113_RS16585	COG0779	Required for maturation of 30S ribosomal subunits
MIC7113_RS16590	COG0195	Participates in both transcription termination and antitermination
MIC7113_RS16600	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MIC7113_RS16600	COG3266	domain, Protein
MIC7113_RS16625	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MIC7113_RS16640	COG2385	sporulation resulting in formation of a cellular spore
MIC7113_RS16645	COG1234	tRNA 3'-trailer cleavage
MIC7113_RS16670	COG0501	Belongs to the peptidase M48B family
MIC7113_RS16700	COG0529	Catalyzes the synthesis of activated sulfate
MIC7113_RS16745	COG0270	DNA (cytosine-5-)-methyltransferase activity
MIC7113_RS16790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MIC7113_RS16795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MIC7113_RS16800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MIC7113_RS16845	COG1649	PFAM Uncharacterised BCR, COG1649
MIC7113_RS16870	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MIC7113_RS16880	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MIC7113_RS16890	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS16900	COG5002	protein histidine kinase activity
MIC7113_RS16915	COG0475	glutathione-regulated potassium exporter activity
MIC7113_RS16920	COG0659	secondary active sulfate transmembrane transporter activity
MIC7113_RS16945	COG0602	queuosine metabolic process
MIC7113_RS16950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MIC7113_RS16970	COG0297	glycogen (starch) synthase activity
MIC7113_RS16980	COG0799	negative regulation of ribosome biogenesis
MIC7113_RS17000	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MIC7113_RS17010	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MIC7113_RS17050	COG1429	ligase activity, forming nitrogen-metal bonds
MIC7113_RS17060	COG0785	Cytochrome C biogenesis protein
MIC7113_RS17065	COG0753	catalase activity
MIC7113_RS17130	COG0746	molybdenum cofactor guanylyltransferase activity
MIC7113_RS17150	COG5002	protein histidine kinase activity
MIC7113_RS17165	COG1252	NADH dehydrogenase
MIC7113_RS17190	COG1215	transferase activity, transferring glycosyl groups
MIC7113_RS17205	COG1192	Involved in chromosome partitioning
MIC7113_RS17210	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MIC7113_RS17215	COG0569	domain protein
MIC7113_RS17215	COG2985	domain, Protein
MIC7113_RS17220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MIC7113_RS17230	COG1104	cysteine desulfurase activity
MIC7113_RS17235	COG0534	Mate efflux family protein
MIC7113_RS17250	COG1752	Esterase of the alpha-beta hydrolase superfamily
MIC7113_RS17270	COG1166	arginine decarboxylase activity
MIC7113_RS17315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MIC7113_RS17335	COG0768	penicillin binding
MIC7113_RS17340	COG0768	penicillin binding
MIC7113_RS17345	COG3842	ATPase activity
MIC7113_RS17355	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MIC7113_RS17360	COG1176	ABC-type spermidine putrescine transport system, permease component I
MIC7113_RS17365	COG1177	transmembrane transport
MIC7113_RS17370	COG2205	protein histidine kinase activity
MIC7113_RS17375	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS17400	COG3307	-O-antigen
MIC7113_RS17410	COG1408	metallophosphoesterase
MIC7113_RS17490	COG1012	belongs to the aldehyde dehydrogenase family
MIC7113_RS17495	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS17510	COG1063	alcohol dehydrogenase
MIC7113_RS17520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MIC7113_RS17525	COG0673	inositol 2-dehydrogenase activity
MIC7113_RS17555	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MIC7113_RS17570	COG2003	Belongs to the UPF0758 family
MIC7113_RS17575	COG0572	uridine kinase
MIC7113_RS17585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MIC7113_RS17590	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MIC7113_RS17595	COG0640	Transcriptional regulator
MIC7113_RS17620	COG1216	Glycosyl transferase, family 2
MIC7113_RS17635	COG0488	(ABC) transporter
MIC7113_RS17650	COG0667	Aldo Keto reductase
MIC7113_RS17660	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MIC7113_RS17665	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS17695	COG1216	Glycosyl transferase, family 2
MIC7113_RS17705	COG3320	Male sterility
MIC7113_RS17705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MIC7113_RS17710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MIC7113_RS17715	COG1619	proteins homologs of microcin C7 resistance protein MccF
MIC7113_RS17720	COG0457	Tetratricopeptide repeat
MIC7113_RS17730	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS17735	COG0697	spore germination
MIC7113_RS17740	COG0616	signal peptide processing
MIC7113_RS17770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MIC7113_RS17790	COG0416	fatty acid biosynthetic process
MIC7113_RS17795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MIC7113_RS17800	COG3850	Histidine kinase
MIC7113_RS17800	COG3437	response regulator, receiver
MIC7113_RS17800	COG2205	protein histidine kinase activity
MIC7113_RS17800	COG4999	Histidine kinase
MIC7113_RS17815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MIC7113_RS17815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MIC7113_RS17825	COG3266	domain, Protein
MIC7113_RS17825	COG2911	Protein conserved in bacteria
MIC7113_RS17825	COG1361	Conserved repeat domain
MIC7113_RS17830	COG2205	protein histidine kinase activity
MIC7113_RS17865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MIC7113_RS17870	COG0750	zinc metalloprotease
MIC7113_RS17890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MIC7113_RS17895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MIC7113_RS17915	COG0473	3-isopropylmalate dehydrogenase activity
MIC7113_RS17925	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MIC7113_RS17935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MIC7113_RS17945	COG2010	Cytochrome c
MIC7113_RS17950	COG2010	Cytochrome c
MIC7113_RS17970	COG0109	protoheme IX farnesyltransferase activity
MIC7113_RS17980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MIC7113_RS17985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MIC7113_RS17990	COG1845	cytochrome c oxidase, subunit III
MIC7113_RS17995	COG0366	Alpha amylase catalytic
MIC7113_RS18000	COG0366	Alpha amylase catalytic
MIC7113_RS18005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MIC7113_RS18035	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MIC7113_RS18040	COG0154	amidase activity
MIC7113_RS18055	COG1554	hydrolase, family 65, central catalytic
MIC7113_RS18060	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS18080	COG0024	Methionine aminopeptidase
MIC7113_RS18090	COG0612	Peptidase, M16
MIC7113_RS18125	COG2319	Wd-40 repeat
MIC7113_RS18125	COG1672	PFAM Archaeal ATPase
MIC7113_RS18130	COG0628	permease
MIC7113_RS18145	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MIC7113_RS18165	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MIC7113_RS18170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MIC7113_RS18190	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MIC7113_RS18210	COG0066	3-isopropylmalate dehydratase activity
MIC7113_RS18215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MIC7113_RS18220	COG2954	triphosphatase activity
MIC7113_RS18225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MIC7113_RS18230	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MIC7113_RS18235	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MIC7113_RS18240	COG1597	lipid kinase activity
MIC7113_RS18265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MIC7113_RS18275	COG5002	protein histidine kinase activity
MIC7113_RS18300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MIC7113_RS18320	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
MIC7113_RS18325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MIC7113_RS18335	COG0163	prenyltransferase activity
MIC7113_RS18340	COG0557	exoribonuclease II activity
MIC7113_RS18350	COG0740	serine-type endopeptidase activity
MIC7113_RS18360	COG0393	Putative heavy-metal-binding
MIC7113_RS18410	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MIC7113_RS18415	COG1132	(ABC) transporter
MIC7113_RS18425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MIC7113_RS18440	COG0297	glycogen (starch) synthase activity
MIC7113_RS18450	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MIC7113_RS18455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MIC7113_RS18495	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MIC7113_RS18500	COG0395	ABC-type sugar transport system, permease component
MIC7113_RS18515	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
MIC7113_RS18520	COG0649	NAD binding
MIC7113_RS18525	COG0275	rRNA processing
MIC7113_RS18540	COG0343	queuine tRNA-ribosyltransferase activity
MIC7113_RS18550	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MIC7113_RS18565	COG4581	dead DEAH box helicase
MIC7113_RS18570	COG2124	cytochrome p450
MIC7113_RS18575	COG1309	transcriptional regulator
MIC7113_RS18585	COG0360	Binds together with S18 to 16S ribosomal RNA
MIC7113_RS18590	COG0179	Fumarylacetoacetate (FAA) hydrolase
MIC7113_RS18605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MIC7113_RS18615	COG1058	Belongs to the CinA family
MIC7113_RS18615	COG1546	Belongs to the CinA family
MIC7113_RS18620	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MIC7113_RS18640	COG1480	7TM receptor with intracellular HD hydrolase
MIC7113_RS18645	COG0039	L-malate dehydrogenase activity
MIC7113_RS18655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MIC7113_RS18695	COG2310	stress, protein
MIC7113_RS18720	COG0372	Belongs to the citrate synthase family
MIC7113_RS18725	COG2062	phosphohistidine phosphatase, SixA
MIC7113_RS18745	COG5001	Diguanylate cyclase
MIC7113_RS18745	COG3706	GGDEF domain
MIC7113_RS18745	COG2203	Gaf domain
MIC7113_RS18745	COG4251	negative regulation of phosphorylation
MIC7113_RS18755	COG0501	Belongs to the peptidase M48B family
MIC7113_RS18800	COG0863	Belongs to the N(4) N(6)-methyltransferase family
MIC7113_RS18805	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MIC7113_RS18845	COG2124	cytochrome p450
MIC7113_RS18860	COG0515	serine threonine protein kinase
MIC7113_RS18860	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS18875	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS18900	COG0723	plastoquinol--plastocyanin reductase activity
MIC7113_RS18910	COG5002	protein histidine kinase activity
MIC7113_RS18910	COG0784	Response regulator, receiver
MIC7113_RS18915	COG1131	(ABC) transporter
MIC7113_RS18930	COG0751	glycine-tRNA ligase activity
MIC7113_RS18935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MIC7113_RS18965	COG5001	Diguanylate cyclase
MIC7113_RS18965	COG2203	Gaf domain
MIC7113_RS18965	COG3706	GGDEF domain
MIC7113_RS18965	COG4251	negative regulation of phosphorylation
MIC7113_RS19000	COG0575	Belongs to the CDS family
MIC7113_RS19010	COG1982	Orn Lys Arg decarboxylase major
MIC7113_RS19020	COG0012	GTP binding
MIC7113_RS19025	COG4953	penicillin-binding protein 1C
MIC7113_RS19060	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MIC7113_RS19075	COG0045	succinate-CoA ligase (ADP-forming) activity
MIC7113_RS19080	COG0300	oxidoreductase activity
MIC7113_RS19110	COG2066	Belongs to the glutaminase family
MIC7113_RS19125	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MIC7113_RS19155	COG0571	ribonuclease III activity
MIC7113_RS19190	COG2172	sigma factor antagonist activity
MIC7113_RS19195	COG1366	Belongs to the anti-sigma-factor antagonist family
MIC7113_RS19200	COG1366	Belongs to the anti-sigma-factor antagonist family
MIC7113_RS19250	COG0494	nUDIX hydrolase
MIC7113_RS19255	COG0667	Aldo Keto reductase
MIC7113_RS19270	COG2198	Histidine kinase
MIC7113_RS19270	COG0784	Response regulator, receiver
MIC7113_RS19270	COG0643	Histidine kinase
MIC7113_RS19275	COG0840	transmembrane signaling receptor activity
MIC7113_RS19275	COG2203	Gaf domain
MIC7113_RS19330	COG1174	glycine betaine transport
MIC7113_RS19345	COG4636	protein conserved in cyanobacteria
MIC7113_RS19360	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MIC7113_RS19365	COG4783	chaperone-mediated protein folding
MIC7113_RS19410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MIC7113_RS19415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MIC7113_RS19435	COG2199	diguanylate cyclase activity
MIC7113_RS19435	COG2203	Gaf domain
MIC7113_RS19465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MIC7113_RS19480	COG0515	serine threonine protein kinase
MIC7113_RS19480	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS19485	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS19485	COG0515	serine threonine protein kinase
MIC7113_RS19495	COG1566	PFAM secretion protein HlyD family protein
MIC7113_RS19505	COG2267	carboxylic ester hydrolase activity
MIC7113_RS19525	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MIC7113_RS19535	COG2852	Protein conserved in bacteria
MIC7113_RS19550	COG2081	HI0933 family
MIC7113_RS19555	COG1773	rubredoxin
MIC7113_RS19560	COG4572	Cation transport regulator
MIC7113_RS19595	COG4106	trans-aconitate 2-methyltransferase activity
MIC7113_RS19600	COG0583	DNA-binding transcription factor activity
MIC7113_RS19605	COG2205	protein histidine kinase activity
MIC7113_RS19605	COG0784	Response regulator, receiver
MIC7113_RS19645	COG0516	GMP reductase activity
MIC7113_RS19645	COG0517	IMP dehydrogenase activity
MIC7113_RS19665	COG1573	uracil-dna glycosylase
MIC7113_RS19690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MIC7113_RS19695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MIC7113_RS19710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIC7113_RS19710	COG4191	Histidine kinase
MIC7113_RS19720	COG0515	serine threonine protein kinase
MIC7113_RS19725	COG0515	serine threonine protein kinase
MIC7113_RS19725	COG3266	domain, Protein
MIC7113_RS19750	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS19770	COG3409	Peptidoglycan-binding domain 1 protein
MIC7113_RS19770	COG3773	Cell wall hydrolase
MIC7113_RS19775	COG0673	inositol 2-dehydrogenase activity
MIC7113_RS19780	COG1201	RNA secondary structure unwinding
MIC7113_RS19785	COG0312	modulator of DNA gyrase
MIC7113_RS19790	COG0312	modulator of DNA gyrase
MIC7113_RS19800	COG1619	proteins homologs of microcin C7 resistance protein MccF
MIC7113_RS19805	COG1461	Dihydroxyacetone kinase
MIC7113_RS19820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MIC7113_RS19840	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MIC7113_RS19855	COG2048	Heterodisulfide reductase, subunit B
MIC7113_RS19860	COG4221	oxidoreductase activity
MIC7113_RS19865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MIC7113_RS19880	COG2244	polysaccharide biosynthetic process
MIC7113_RS19890	COG0463	Glycosyl transferase, family 2
MIC7113_RS19890	COG1216	Glycosyl transferase, family 2
MIC7113_RS19895	COG1216	Glycosyl transferase, family 2
MIC7113_RS19895	COG0463	Glycosyl transferase, family 2
MIC7113_RS19900	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS19905	COG0463	Glycosyl transferase, family 2
MIC7113_RS19905	COG1216	Glycosyl transferase, family 2
MIC7113_RS19915	COG4447	cellulose binding
MIC7113_RS19925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MIC7113_RS19945	COG0826	peptidase U32
MIC7113_RS19950	COG0628	permease
MIC7113_RS19970	COG5002	protein histidine kinase activity
MIC7113_RS19970	COG0784	Response regulator, receiver
MIC7113_RS19980	COG4251	negative regulation of phosphorylation
MIC7113_RS19990	COG2197	response regulator
MIC7113_RS19995	COG2204	response regulator
MIC7113_RS20045	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS20055	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MIC7113_RS20080	COG0424	maF-like protein
MIC7113_RS20100	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
MIC7113_RS20125	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS20125	COG0515	serine threonine protein kinase
MIC7113_RS20135	COG0497	DNA recombination
MIC7113_RS20140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MIC7113_RS20155	COG0515	serine threonine protein kinase
MIC7113_RS20155	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS20165	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS20165	COG0515	serine threonine protein kinase
MIC7113_RS20170	COG0484	heat shock protein binding
MIC7113_RS20180	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MIC7113_RS20185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MIC7113_RS20190	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
MIC7113_RS20195	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
MIC7113_RS20200	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
MIC7113_RS20205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MIC7113_RS20205	COG4451	ribulose bisphosphate carboxylase, small
MIC7113_RS20210	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MIC7113_RS20215	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
MIC7113_RS20220	COG0583	DNA-binding transcription factor activity
MIC7113_RS20225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MIC7113_RS20275	COG2045	Belongs to the ComB family
MIC7113_RS20280	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MIC7113_RS20285	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MIC7113_RS20290	COG2199	diguanylate cyclase activity
MIC7113_RS20290	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MIC7113_RS20295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MIC7113_RS20305	COG0488	(ABC) transporter
MIC7113_RS20310	COG4106	trans-aconitate 2-methyltransferase activity
MIC7113_RS20315	COG0384	phenazine biosynthesis protein PhzF
MIC7113_RS20320	COG0671	phosphoesterase, PA-phosphatase related
MIC7113_RS20330	COG0426	domain, Protein
MIC7113_RS20330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MIC7113_RS20350	COG0426	domain, Protein
MIC7113_RS20350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MIC7113_RS20360	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MIC7113_RS20365	COG0508	dehydrogenase complex catalyzes the overall conversion of
MIC7113_RS20365	COG0596	Alpha beta hydrolase
MIC7113_RS20380	COG0165	Argininosuccinate lyase
MIC7113_RS20390	COG2208	phosphoserine phosphatase activity
MIC7113_RS20395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MIC7113_RS20405	COG4191	Histidine kinase
MIC7113_RS20405	COG0784	Response regulator, receiver
MIC7113_RS20410	COG1070	Carbohydrate kinase
MIC7113_RS20425	COG3621	Patatin-like phospholipase
MIC7113_RS20440	COG1028	Short-chain dehydrogenase reductase Sdr
MIC7113_RS20455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MIC7113_RS20455	COG0758	DNA mediated transformation
MIC7113_RS20480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MIC7113_RS20485	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS20500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MIC7113_RS20505	COG0581	inorganic phosphate transmembrane transporter activity
MIC7113_RS20510	COG0573	inorganic phosphate transmembrane transporter activity
MIC7113_RS20515	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MIC7113_RS20535	COG0848	biopolymer transport protein
MIC7113_RS20540	COG0811	peptide transport
MIC7113_RS20550	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MIC7113_RS20555	COG3781	membrane
MIC7113_RS20560	COG3781	membrane
MIC7113_RS20570	COG1028	Short-chain dehydrogenase reductase Sdr
MIC7113_RS20585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MIC7113_RS20610	COG1490	D-aminoacyl-tRNA deacylase activity
MIC7113_RS20620	COG0523	cobalamin synthesis protein
MIC7113_RS20625	COG0215	cysteine-tRNA ligase activity
MIC7113_RS20670	COG1324	tolerance protein
MIC7113_RS20685	COG0629	single-stranded DNA binding
MIC7113_RS20690	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MIC7113_RS20700	COG2099	Precorrin-6x reductase
MIC7113_RS20715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MIC7113_RS20720	COG0740	serine-type endopeptidase activity
MIC7113_RS20725	COG0544	peptidyl-prolyl cis-trans isomerase activity
MIC7113_RS20730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MIC7113_RS20735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MIC7113_RS20740	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MIC7113_RS20760	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MIC7113_RS20785	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MIC7113_RS20790	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MIC7113_RS20795	COG4208	sulfate ABC transporter
MIC7113_RS20800	COG5002	protein histidine kinase activity
MIC7113_RS20800	COG0784	Response regulator, receiver
MIC7113_RS20810	COG0784	Response regulator, receiver
MIC7113_RS20825	COG2201	protein-glutamate methylesterase activity
MIC7113_RS20830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MIC7113_RS20840	COG0436	Aminotransferase
MIC7113_RS20855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MIC7113_RS20865	COG1845	cytochrome c oxidase, subunit III
MIC7113_RS20925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MIC7113_RS20930	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MIC7113_RS20940	COG1595	DNA-templated transcription, initiation
MIC7113_RS20945	COG0784	Response regulator, receiver
MIC7113_RS20950	COG1376	ErfK ybiS ycfS ynhG family protein
MIC7113_RS20960	COG0739	heme binding
MIC7113_RS20975	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MIC7113_RS20985	COG0412	Dienelactone hydrolase
MIC7113_RS21005	COG1215	transferase activity, transferring glycosyl groups
MIC7113_RS21010	COG0463	Glycosyl transferase, family 2
MIC7113_RS21025	COG2203	Gaf domain
MIC7113_RS21025	COG0840	transmembrane signaling receptor activity
MIC7113_RS21030	COG1366	Belongs to the anti-sigma-factor antagonist family
MIC7113_RS21030	COG2202	Pas domain
MIC7113_RS21035	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MIC7113_RS21040	COG0589	response to stress
MIC7113_RS21045	COG0126	phosphoglycerate kinase activity
MIC7113_RS21100	COG0719	Fe-S assembly protein
MIC7113_RS21105	COG0396	ATPase activity
MIC7113_RS21110	COG0719	Fe-S assembly protein
MIC7113_RS21115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MIC7113_RS21190	COG1702	phosphate starvation-inducible protein PhoH
MIC7113_RS21195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MIC7113_RS21200	COG0228	four-way junction DNA binding
MIC7113_RS21205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MIC7113_RS21215	COG0784	Response regulator, receiver
MIC7113_RS21215	COG0835	chemotaxis
MIC7113_RS21235	COG1073	alpha beta
MIC7113_RS21235	COG2226	methyltransferase
MIC7113_RS21245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MIC7113_RS21245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MIC7113_RS21255	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MIC7113_RS21260	COG4095	Psort location CytoplasmicMembrane, score
MIC7113_RS21285	COG1472	Belongs to the glycosyl hydrolase 3 family
MIC7113_RS21290	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MIC7113_RS21295	COG0009	L-threonylcarbamoyladenylate synthase
MIC7113_RS21305	COG0587	DNA-directed DNA polymerase activity
MIC7113_RS21320	COG0463	Glycosyl transferase, family 2
MIC7113_RS21340	COG0515	serine threonine protein kinase
MIC7113_RS21340	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS21370	COG2205	protein histidine kinase activity
MIC7113_RS21430	COG1361	Conserved repeat domain
MIC7113_RS21435	COG1596	polysaccharide export
MIC7113_RS21440	COG0489	protein tyrosine kinase activity
MIC7113_RS21445	COG0023	Translation Initiation Factor
MIC7113_RS21455	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MIC7113_RS21465	COG2205	protein histidine kinase activity
MIC7113_RS21465	COG3437	response regulator, receiver
MIC7113_RS21465	COG3850	Histidine kinase
MIC7113_RS21465	COG4999	Histidine kinase
MIC7113_RS21475	COG0481	GTPase activity
MIC7113_RS21480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MIC7113_RS21485	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MIC7113_RS21490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MIC7113_RS21500	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MIC7113_RS21510	COG3852	Histidine kinase
MIC7113_RS21535	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MIC7113_RS21570	COG1598	PFAM Uncharacterised protein family UPF0150
MIC7113_RS21590	COG0459	protein refolding
MIC7113_RS21595	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MIC7113_RS21600	COG3411	Ferredoxin
MIC7113_RS21605	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS21615	COG1085	galactose-1-phosphate uridylyltransferase
MIC7113_RS21625	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MIC7113_RS21640	COG0371	Dehydrogenase
MIC7113_RS21645	COG0436	Aminotransferase
MIC7113_RS21655	COG3788	relative of glutathione S-transferase, MAPEG superfamily
MIC7113_RS21665	COG0784	Response regulator, receiver
MIC7113_RS21670	COG4251	negative regulation of phosphorylation
MIC7113_RS21675	COG0784	Response regulator, receiver
MIC7113_RS21680	COG0697	spore germination
MIC7113_RS21715	COG0667	Aldo Keto reductase
MIC7113_RS21720	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MIC7113_RS21735	COG4555	ABC transporter
MIC7113_RS21740	COG0724	RNA recognition motif
MIC7113_RS21745	COG0024	Methionine aminopeptidase
MIC7113_RS21750	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MIC7113_RS21755	COG0508	dehydrogenase complex catalyzes the overall conversion of
MIC7113_RS21755	COG0022	dehydrogenase e1 component
MIC7113_RS21760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MIC7113_RS21765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MIC7113_RS21780	COG1295	ribonuclease BN
MIC7113_RS21795	COG0058	SHG alpha-glucan phosphorylase activity
MIC7113_RS21815	COG0395	ABC-type sugar transport system, permease component
MIC7113_RS21820	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
MIC7113_RS21825	COG5322	oxidoreductase activity
MIC7113_RS21830	COG0825	malonyl-CoA metabolic process
MIC7113_RS21835	COG1028	Short-chain dehydrogenase reductase Sdr
MIC7113_RS21840	COG0302	gtp cyclohydrolase
MIC7113_RS21845	COG5002	protein histidine kinase activity
MIC7113_RS21880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MIC7113_RS21885	COG1570	exodeoxyribonuclease VII activity
MIC7113_RS21915	COG1722	exodeoxyribonuclease VII activity
MIC7113_RS21950	COG0589	response to stress
MIC7113_RS21950	COG0475	glutathione-regulated potassium exporter activity
MIC7113_RS22025	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MIC7113_RS22030	COG0513	Belongs to the DEAD box helicase family
MIC7113_RS22035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MIC7113_RS22040	COG0434	BtpA family
MIC7113_RS22045	COG4243	Vitamin k epoxide reductase
MIC7113_RS22070	COG0405	Gamma-glutamyltransferase
MIC7113_RS22080	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MIC7113_RS22090	COG0450	alkyl hydroperoxide reductase
MIC7113_RS22115	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MIC7113_RS22130	COG0346	lactoylglutathione lyase activity
MIC7113_RS22145	COG0563	adenylate kinase activity
MIC7113_RS22150	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MIC7113_RS22160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MIC7113_RS22175	COG1836	PFAM Integral membrane protein DUF92
MIC7113_RS22195	COG0724	RNA recognition motif
MIC7113_RS22200	COG1803	Methylglyoxal synthase
MIC7113_RS22200	COG1597	lipid kinase activity
MIC7113_RS22215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MIC7113_RS22215	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
MIC7113_RS22230	COG1492	cobalamin metabolic process
MIC7113_RS22240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MIC7113_RS22260	COG2131	deaminase
MIC7113_RS22275	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS22275	COG2205	protein histidine kinase activity
MIC7113_RS22275	COG3292	Two component regulator propeller
MIC7113_RS22305	COG0668	transmembrane transport
MIC7113_RS22320	COG0668	transmembrane transport
MIC7113_RS22325	COG0668	transmembrane transport
MIC7113_RS22365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MIC7113_RS22375	COG0628	permease
MIC7113_RS22410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MIC7113_RS22420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MIC7113_RS22425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MIC7113_RS22430	COG0776	regulation of translation
MIC7113_RS22435	COG1450	Type ii and iii secretion system protein
MIC7113_RS22470	COG1361	Conserved repeat domain
MIC7113_RS22470	COG2911	Protein conserved in bacteria
MIC7113_RS22470	COG3266	domain, Protein
MIC7113_RS22475	COG1361	Conserved repeat domain
MIC7113_RS22495	COG1316	TRANSCRIPTIONal
MIC7113_RS22505	COG0010	Belongs to the arginase family
MIC7113_RS22515	COG0528	UMP kinase activity
MIC7113_RS22520	COG0233	cytoplasmic translational termination
MIC7113_RS22535	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MIC7113_RS22540	COG0546	phosphoglycolate phosphatase activity
MIC7113_RS22545	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MIC7113_RS22575	COG2161	toxin-antitoxin pair type II binding
MIC7113_RS22600	COG0714	Associated with various cellular activities
MIC7113_RS22605	COG0196	riboflavin kinase activity
MIC7113_RS22610	COG1234	tRNA 3'-trailer cleavage
MIC7113_RS22615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MIC7113_RS22620	COG0189	ligase activity
MIC7113_RS22645	COG0339	signal peptide processing
MIC7113_RS22665	COG0285	dihydrofolate synthase activity
MIC7113_RS22675	COG1397	ADP-ribosylglycohydrolase
MIC7113_RS22735	COG1049	propionate catabolic process, 2-methylcitrate cycle
MIC7113_RS22745	COG2010	Cytochrome c
MIC7113_RS22750	COG0742	ribosomal rna small subunit methyltransferase
MIC7113_RS22755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MIC7113_RS22760	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MIC7113_RS22850	COG0237	dephospho-CoA kinase activity
MIC7113_RS22880	COG0436	Aminotransferase
MIC7113_RS22900	COG1696	Membrane protein involved in D-alanine export
MIC7113_RS22915	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MIC7113_RS22920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MIC7113_RS22920	COG0574	Belongs to the PEP-utilizing enzyme family
MIC7113_RS22935	COG2205	protein histidine kinase activity
MIC7113_RS22935	COG0784	Response regulator, receiver
MIC7113_RS22955	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MIC7113_RS22960	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MIC7113_RS22965	COG4208	sulfate ABC transporter
MIC7113_RS22980	COG0574	Belongs to the PEP-utilizing enzyme family
MIC7113_RS22980	COG3848	Pyruvate phosphate dikinase
MIC7113_RS22990	COG2911	Protein conserved in bacteria
MIC7113_RS22990	COG1361	Conserved repeat domain
MIC7113_RS22990	COG3266	domain, Protein
MIC7113_RS23010	COG1175	transmembrane transport
MIC7113_RS23030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MIC7113_RS23030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MIC7113_RS23050	COG0024	Methionine aminopeptidase
MIC7113_RS23065	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MIC7113_RS23065	COG0140	phosphoribosyl-ATP diphosphatase activity
MIC7113_RS23075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MIC7113_RS23085	COG1666	GTP binding
MIC7113_RS23125	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MIC7113_RS23135	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MIC7113_RS23190	COG1278	Cold shock
MIC7113_RS23200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MIC7113_RS23205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MIC7113_RS23210	COG1116	anion transmembrane transporter activity
MIC7113_RS23210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MIC7113_RS23215	COG1116	anion transmembrane transporter activity
MIC7113_RS23225	COG4251	negative regulation of phosphorylation
MIC7113_RS23230	COG3447	MASE1 domain protein
MIC7113_RS23230	COG5001	Diguanylate cyclase
MIC7113_RS23230	COG5002	protein histidine kinase activity
MIC7113_RS23240	COG5002	protein histidine kinase activity
MIC7113_RS23250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MIC7113_RS23250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MIC7113_RS23265	COG2988	succinylglutamate desuccinylase activity
MIC7113_RS23275	COG0405	Gamma-glutamyltransferase
MIC7113_RS23285	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MIC7113_RS23300	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MIC7113_RS23340	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
MIC7113_RS23360	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MIC7113_RS23385	COG0538	isocitrate dehydrogenase activity
MIC7113_RS23390	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS23395	COG0515	serine threonine protein kinase
MIC7113_RS23400	COG2202	Pas domain
MIC7113_RS23400	COG2205	protein histidine kinase activity
MIC7113_RS23410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MIC7113_RS23420	COG0515	serine threonine protein kinase
MIC7113_RS23420	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS23430	COG0429	hydrolase of the alpha beta-hydrolase fold
MIC7113_RS23435	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS23445	COG0644	oxidoreductase
MIC7113_RS23450	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MIC7113_RS23455	COG0747	negative chemotaxis
MIC7113_RS23460	COG2385	sporulation resulting in formation of a cellular spore
MIC7113_RS23485	COG0181	hydroxymethylbilane synthase activity
MIC7113_RS23490	COG5398	heme oxygenase
MIC7113_RS23495	COG2197	response regulator
MIC7113_RS23500	COG0297	glycogen (starch) synthase activity
MIC7113_RS23555	COG0460	homoserine dehydrogenase
MIC7113_RS23585	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS23645	COG1192	Involved in chromosome partitioning
MIC7113_RS23700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MIC7113_RS23710	COG0426	domain, Protein
MIC7113_RS23710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MIC7113_RS23735	COG0426	domain, Protein
MIC7113_RS23735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MIC7113_RS23745	COG4251	negative regulation of phosphorylation
MIC7113_RS23760	COG1132	(ABC) transporter
MIC7113_RS23770	COG2264	protein methyltransferase activity
MIC7113_RS23775	COG3239	Fatty acid desaturase
MIC7113_RS23810	COG0586	Pfam SNARE associated Golgi protein
MIC7113_RS23815	COG3932	Exopolysaccharide synthesis, ExoD
MIC7113_RS23825	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MIC7113_RS23835	COG0668	transmembrane transport
MIC7113_RS23875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MIC7113_RS23885	COG3781	membrane
MIC7113_RS23895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MIC7113_RS23910	COG0288	reversible hydration of carbon dioxide
MIC7113_RS23925	COG0419	ATPase involved in DNA repair
MIC7113_RS23960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MIC7113_RS23970	COG0860	N-Acetylmuramoyl-L-alanine amidase
MIC7113_RS23970	COG3103	Sh3 type 3 domain protein
MIC7113_RS23970	COG4991	sh3 domain protein
MIC7113_RS23980	COG0463	Glycosyl transferase, family 2
MIC7113_RS23980	COG1216	Glycosyl transferase, family 2
MIC7113_RS23985	COG1216	Glycosyl transferase, family 2
MIC7113_RS23990	COG0463	Glycosyl transferase, family 2
MIC7113_RS23990	COG1216	Glycosyl transferase, family 2
MIC7113_RS23995	COG1216	Glycosyl transferase, family 2
MIC7113_RS23995	COG0463	Glycosyl transferase, family 2
MIC7113_RS24005	COG0542	response to heat
MIC7113_RS24010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MIC7113_RS24025	COG0004	ammonium transporteR
MIC7113_RS24030	COG1361	Conserved repeat domain
MIC7113_RS24030	COG3266	domain, Protein
MIC7113_RS24030	COG2911	Protein conserved in bacteria
MIC7113_RS24035	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MIC7113_RS24040	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MIC7113_RS24055	COG1994	Peptidase M50
MIC7113_RS24065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MIC7113_RS24100	COG2363	Small membrane protein
MIC7113_RS24145	COG0017	Asparaginyl-tRNA synthetase
MIC7113_RS24170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MIC7113_RS24220	COG0492	ferredoxin-NADP+ reductase activity
MIC7113_RS24235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MIC7113_RS24240	COG1940	carbohydrate kinase activity
MIC7113_RS24260	COG0504	CTP synthase activity
MIC7113_RS24265	COG0482	sulfurtransferase activity
MIC7113_RS24280	COG0326	Molecular chaperone. Has ATPase activity
MIC7113_RS24285	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MIC7113_RS24310	COG4968	Prepilin-type N-terminal cleavage methylation domain
MIC7113_RS24320	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MIC7113_RS24345	COG1331	Highly conserved protein containing a thioredoxin domain
MIC7113_RS24355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MIC7113_RS24360	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MIC7113_RS24380	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
MIC7113_RS24395	COG2198	Histidine kinase
MIC7113_RS24395	COG0643	Histidine kinase
MIC7113_RS24420	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS24435	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MIC7113_RS24440	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MIC7113_RS24445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MIC7113_RS24450	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MIC7113_RS24455	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MIC7113_RS24500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MIC7113_RS24505	COG0398	Pfam SNARE associated Golgi protein
MIC7113_RS24520	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MIC7113_RS24525	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MIC7113_RS24535	COG2897	thiosulfate sulfurtransferase activity
MIC7113_RS24545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MIC7113_RS24555	COG2226	methyltransferase
MIC7113_RS24570	COG0514	ATP-dependent DNA helicase (RecQ)
MIC7113_RS24575	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS24575	COG0515	serine threonine protein kinase
MIC7113_RS24585	COG0702	epimerase
MIC7113_RS24590	COG0071	Belongs to the small heat shock protein (HSP20) family
MIC7113_RS24600	COG1045	serine acetyltransferase
MIC7113_RS24605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MIC7113_RS24610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MIC7113_RS24630	COG2319	Wd-40 repeat
MIC7113_RS24630	COG5635	Nacht domain
MIC7113_RS24640	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MIC7113_RS24645	COG0519	Catalyzes the synthesis of GMP from XMP
MIC7113_RS24645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MIC7113_RS24655	COG0037	tRNA processing
MIC7113_RS24670	COG0408	coproporphyrinogen oxidase activity
MIC7113_RS24675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MIC7113_RS24680	COG0583	DNA-binding transcription factor activity
MIC7113_RS24690	COG2264	protein methyltransferase activity
MIC7113_RS24695	COG0531	amino acid
MIC7113_RS24700	COG1653	transport
MIC7113_RS24730	COG5002	protein histidine kinase activity
MIC7113_RS24755	COG2319	Wd-40 repeat
MIC7113_RS24760	COG0358	DNA primase activity
MIC7113_RS24770	COG0792	nuclease activity
MIC7113_RS24780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MIC7113_RS24790	COG0569	domain protein
MIC7113_RS24795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MIC7113_RS24800	COG2226	methyltransferase
MIC7113_RS24810	COG1006	Multisubunit Na H antiporter MnhC subunit
MIC7113_RS24815	COG0651	ATP synthesis coupled electron transport
MIC7113_RS24855	COG0778	Nitroreductase
MIC7113_RS24865	COG0412	Dienelactone hydrolase
MIC7113_RS24870	COG0539	negative regulation of cytoplasmic translation
MIC7113_RS24885	COG0612	Peptidase, M16
MIC7113_RS24890	COG3001	Fructosamine kinase
MIC7113_RS24905	COG1420	regulation of RNA biosynthetic process
MIC7113_RS24910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MIC7113_RS24910	COG0425	Belongs to the sulfur carrier protein TusA family
MIC7113_RS24925	COG0135	phosphoribosylanthranilate isomerase activity
MIC7113_RS24955	COG2361	Protein of unknown function DUF86
MIC7113_RS24960	COG2723	6-phospho-beta-galactosidase activity
MIC7113_RS24980	COG4178	(ABC) transporter
MIC7113_RS24995	COG0116	Belongs to the methyltransferase superfamily
MIC7113_RS25000	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MIC7113_RS25010	COG2267	carboxylic ester hydrolase activity
MIC7113_RS25030	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
MIC7113_RS25035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MIC7113_RS25050	COG1797	cobyrinic acid a,c-diamide synthase activity
MIC7113_RS25055	COG3409	Peptidoglycan-binding domain 1 protein
MIC7113_RS25055	COG3429	Glucose-6-phosphate dehydrogenase subunit
MIC7113_RS25060	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MIC7113_RS25065	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MIC7113_RS25070	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MIC7113_RS25075	COG0205	6-phosphofructokinase activity
MIC7113_RS25080	COG0724	RNA recognition motif
MIC7113_RS25095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MIC7113_RS25105	COG1045	serine acetyltransferase
MIC7113_RS25115	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MIC7113_RS25125	COG1376	ErfK ybiS ycfS ynhG family protein
MIC7113_RS25130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MIC7113_RS25135	COG0741	lytic transglycosylase activity
MIC7113_RS25140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MIC7113_RS25155	COG1120	ATPase activity
MIC7113_RS25160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MIC7113_RS25165	COG0805	protein transport
MIC7113_RS25180	COG0723	plastoquinol--plastocyanin reductase activity
MIC7113_RS25185	COG3258	Cytochrome c
MIC7113_RS25205	COG0297	glycogen (starch) synthase activity
MIC7113_RS25215	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MIC7113_RS25220	COG0003	Pfam Anion-transporting ATPase
MIC7113_RS25240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MIC7113_RS25250	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS25260	COG0367	asparagine synthase
MIC7113_RS25295	COG0728	peptidoglycan biosynthetic process
MIC7113_RS25305	COG1086	Polysaccharide biosynthesis protein
MIC7113_RS25360	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS25375	COG1160	GTP binding
MIC7113_RS25380	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MIC7113_RS25420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MIC7113_RS25435	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MIC7113_RS25440	COG1799	cell septum assembly
MIC7113_RS25445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MIC7113_RS25450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MIC7113_RS25465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MIC7113_RS25470	COG0840	transmembrane signaling receptor activity
MIC7113_RS25485	COG0784	Response regulator, receiver
MIC7113_RS25495	COG0037	tRNA processing
MIC7113_RS25505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MIC7113_RS25520	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MIC7113_RS25530	COG0398	Pfam SNARE associated Golgi protein
MIC7113_RS25535	COG0463	Glycosyl transferase, family 2
MIC7113_RS25575	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
MIC7113_RS25585	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MIC7113_RS25625	COG1301	dicarboxylic acid transport
MIC7113_RS25640	COG0484	heat shock protein binding
MIC7113_RS25650	COG0740	serine-type endopeptidase activity
MIC7113_RS25655	COG0740	serine-type endopeptidase activity
MIC7113_RS25660	COG2304	oxidoreductase activity
MIC7113_RS25665	COG0784	Response regulator, receiver
MIC7113_RS25680	COG2203	Gaf domain
MIC7113_RS25680	COG0840	transmembrane signaling receptor activity
MIC7113_RS25685	COG0784	Response regulator, receiver
MIC7113_RS25685	COG2198	Histidine kinase
MIC7113_RS25685	COG0643	Histidine kinase
MIC7113_RS25690	COG4956	integral membrane protein (PIN domain superfamily)
MIC7113_RS25695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MIC7113_RS25705	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MIC7113_RS25715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MIC7113_RS25725	COG0443	Heat shock 70 kDa protein
MIC7113_RS25730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MIC7113_RS25735	COG0724	RNA recognition motif
MIC7113_RS25740	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MIC7113_RS25745	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MIC7113_RS25755	COG0563	adenylate kinase activity
MIC7113_RS25760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MIC7113_RS25765	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MIC7113_RS25770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MIC7113_RS25775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MIC7113_RS25780	COG3842	ATPase activity
MIC7113_RS25785	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MIC7113_RS25815	COG1484	DNA-dependent DNA replication
MIC7113_RS25830	COG3850	Histidine kinase
MIC7113_RS25830	COG2205	protein histidine kinase activity
MIC7113_RS25830	COG4999	Histidine kinase
MIC7113_RS25830	COG3437	response regulator, receiver
MIC7113_RS25835	COG0571	ribonuclease III activity
MIC7113_RS25850	COG0598	Magnesium transport protein CorA
MIC7113_RS25855	COG0459	protein refolding
MIC7113_RS25860	COG0640	Transcriptional regulator
MIC7113_RS25865	COG3118	belongs to the thioredoxin family
MIC7113_RS25875	COG0625	glutathione transferase activity
MIC7113_RS25880	COG1902	pentaerythritol trinitrate reductase activity
MIC7113_RS25885	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MIC7113_RS25895	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MIC7113_RS25900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MIC7113_RS25920	COG0328	RNA-DNA hybrid ribonuclease activity
MIC7113_RS25930	COG1215	transferase activity, transferring glycosyl groups
MIC7113_RS25935	COG0300	oxidoreductase activity
MIC7113_RS25935	COG3000	fatty acid hydroxylase
MIC7113_RS25940	COG1217	gtp-binding protein TYPA
MIC7113_RS25950	COG0408	coproporphyrinogen oxidase activity
MIC7113_RS25970	COG3118	belongs to the thioredoxin family
MIC7113_RS25975	COG1028	Short-chain dehydrogenase reductase Sdr
MIC7113_RS26020	COG0415	Belongs to the DNA photolyase family
MIC7113_RS26025	COG0747	negative chemotaxis
MIC7113_RS26030	COG0463	Glycosyl transferase, family 2
MIC7113_RS26030	COG1216	Glycosyl transferase, family 2
MIC7113_RS26035	COG0601	transmembrane transport
MIC7113_RS26040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MIC7113_RS26050	COG0577	efflux transmembrane transporter activity
MIC7113_RS26050	COG1136	(ABC) transporter
MIC7113_RS26070	COG0251	oxidation-reduction process
MIC7113_RS26080	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MIC7113_RS26110	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS26120	COG1178	ABC-type Fe3 transport system permease component
MIC7113_RS26130	COG1840	ABC-type Fe3 transport system, periplasmic component
MIC7113_RS26135	COG1840	ABC-type Fe3 transport system, periplasmic component
MIC7113_RS26140	COG0251	oxidation-reduction process
MIC7113_RS26150	COG1640	4-alpha-glucanotransferase
MIC7113_RS26160	COG1187	pseudouridine synthase activity
MIC7113_RS26195	COG0277	FAD linked oxidase domain protein
MIC7113_RS26200	COG0247	lactate metabolic process
MIC7113_RS26220	COG2217	Heavy metal translocating P-type atpase
MIC7113_RS26225	COG5001	Diguanylate cyclase
MIC7113_RS26225	COG1716	ATPase activity
MIC7113_RS26235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MIC7113_RS26240	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MIC7113_RS26245	COG0529	Catalyzes the synthesis of activated sulfate
MIC7113_RS26260	COG0110	maltose O-acetyltransferase activity
MIC7113_RS26290	COG1126	abc transporter atp-binding protein
MIC7113_RS26295	COG0765	amino acid transport
MIC7113_RS26300	COG3237	CsbD-like
MIC7113_RS26310	COG2205	protein histidine kinase activity
MIC7113_RS26335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MIC7113_RS26345	COG0720	synthase
MIC7113_RS26350	COG0484	heat shock protein binding
MIC7113_RS26355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MIC7113_RS26360	COG1959	2 iron, 2 sulfur cluster binding
MIC7113_RS26365	COG3659	wide pore channel activity
MIC7113_RS26370	COG3659	wide pore channel activity
MIC7113_RS26375	COG2154	pterin-4-alpha-carbinolamine dehydratase
MIC7113_RS26390	COG1122	ATPase activity
MIC7113_RS26395	COG3688	RNA-binding protein containing a PIN domain
MIC7113_RS26415	COG0762	integral membrane protein
MIC7113_RS26425	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MIC7113_RS26475	COG5002	protein histidine kinase activity
MIC7113_RS26475	COG3850	Histidine kinase
MIC7113_RS26480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MIC7113_RS26485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MIC7113_RS26505	COG0540	Belongs to the ATCase OTCase family
MIC7113_RS26510	COG2239	Acts as a magnesium transporter
MIC7113_RS26520	COG2094	Belongs to the DNA glycosylase MPG family
MIC7113_RS26530	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MIC7113_RS26565	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MIC7113_RS26575	COG3631	Ketosteroid isomerase-related protein
MIC7113_RS26600	COG1136	(ABC) transporter
MIC7113_RS26605	COG1136	(ABC) transporter
MIC7113_RS26605	COG0577	efflux transmembrane transporter activity
MIC7113_RS26610	COG1566	PFAM secretion protein HlyD family protein
MIC7113_RS26625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MIC7113_RS26645	COG4636	protein conserved in cyanobacteria
MIC7113_RS26660	COG0515	serine threonine protein kinase
MIC7113_RS26665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MIC7113_RS26680	COG0142	geranyltranstransferase activity
MIC7113_RS26690	COG1819	glycosyl
MIC7113_RS26705	COG0406	alpha-ribazole phosphatase activity
MIC7113_RS26720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MIC7113_RS26725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MIC7113_RS26730	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MIC7113_RS26735	COG0085	RNA polymerase activity
MIC7113_RS26740	COG0084	hydrolase, TatD family'
MIC7113_RS26745	COG0268	Binds directly to 16S ribosomal RNA
MIC7113_RS26750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MIC7113_RS26755	COG0589	response to stress
MIC7113_RS26775	COG2274	protein secretion by the type I secretion system
MIC7113_RS26790	COG0702	epimerase
MIC7113_RS26805	COG0666	response to abiotic stimulus
MIC7113_RS26825	COG3751	2OG-Fe(II) oxygenase superfamily
MIC7113_RS26835	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MIC7113_RS26860	COG1252	NADH dehydrogenase
MIC7113_RS26880	COG0494	nUDIX hydrolase
MIC7113_RS26895	COG2119	membrane
MIC7113_RS26900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MIC7113_RS26920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MIC7113_RS26930	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MIC7113_RS26935	COG0052	Belongs to the universal ribosomal protein uS2 family
MIC7113_RS26940	COG3852	Histidine kinase
MIC7113_RS26945	COG1216	Glycosyl transferase, family 2
MIC7113_RS26970	COG1842	Phage shock protein A
MIC7113_RS26975	COG1842	Phage shock protein A
MIC7113_RS26980	COG3118	belongs to the thioredoxin family
MIC7113_RS26985	COG0436	Aminotransferase
MIC7113_RS26995	COG1164	Oligoendopeptidase f
MIC7113_RS27000	COG0322	excinuclease ABC activity
MIC7113_RS27005	COG1943	Transposase
MIC7113_RS27040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MIC7113_RS27055	COG0297	glycogen (starch) synthase activity
MIC7113_RS27060	COG0572	uridine kinase
MIC7113_RS27075	COG0667	Aldo Keto reductase
MIC7113_RS27095	COG0322	excinuclease ABC activity
MIC7113_RS27110	COG1649	PFAM Uncharacterised BCR, COG1649
MIC7113_RS27120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MIC7113_RS27130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MIC7113_RS27175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MIC7113_RS27205	COG0724	RNA recognition motif
MIC7113_RS27210	COG3119	arylsulfatase activity
MIC7113_RS27215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MIC7113_RS27235	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MIC7113_RS27245	COG0702	epimerase
MIC7113_RS27250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MIC7113_RS27260	COG0784	Response regulator, receiver
MIC7113_RS27260	COG2205	protein histidine kinase activity
MIC7113_RS27300	COG3781	membrane
MIC7113_RS27320	COG0668	transmembrane transport
MIC7113_RS27325	COG2319	Wd-40 repeat
MIC7113_RS27325	COG1672	PFAM Archaeal ATPase
MIC7113_RS27335	COG0534	Mate efflux family protein
MIC7113_RS27360	COG0784	Response regulator, receiver
MIC7113_RS27370	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS27395	COG0134	indole-3-glycerol-phosphate synthase activity
MIC7113_RS27400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MIC7113_RS27410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MIC7113_RS27440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MIC7113_RS27445	COG1090	epimerase
MIC7113_RS27475	COG2205	protein histidine kinase activity
MIC7113_RS27480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MIC7113_RS27485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MIC7113_RS27505	COG5001	Diguanylate cyclase
MIC7113_RS27505	COG4251	negative regulation of phosphorylation
MIC7113_RS27505	COG3706	GGDEF domain
MIC7113_RS27505	COG2203	Gaf domain
MIC7113_RS27510	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS27530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MIC7113_RS27540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MIC7113_RS27545	COG1494	fructose-1,6-bisphosphatase
MIC7113_RS27550	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MIC7113_RS27555	COG1615	UPF0182 protein
MIC7113_RS27565	COG0463	Glycosyl transferase, family 2
MIC7113_RS27575	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS27580	COG0297	glycogen (starch) synthase activity
MIC7113_RS27595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MIC7113_RS27635	COG2226	methyltransferase
MIC7113_RS27650	COG0297	glycogen (starch) synthase activity
MIC7113_RS27655	COG1215	transferase activity, transferring glycosyl groups
MIC7113_RS27715	COG0489	protein tyrosine kinase activity
MIC7113_RS27720	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS27730	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS27735	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS27770	COG0189	ligase activity
MIC7113_RS27770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MIC7113_RS27780	COG4242	Belongs to the peptidase S51 family
MIC7113_RS27790	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MIC7113_RS27815	COG1151	hydroxylamine reductase activity
MIC7113_RS27825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MIC7113_RS27875	COG1733	regulation of RNA biosynthetic process
MIC7113_RS27915	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MIC7113_RS27920	COG1597	lipid kinase activity
MIC7113_RS27920	COG1803	Methylglyoxal synthase
MIC7113_RS27925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MIC7113_RS27940	COG4172	Belongs to the ABC transporter superfamily
MIC7113_RS27945	COG0848	biopolymer transport protein
MIC7113_RS27960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MIC7113_RS27965	COG0601	transmembrane transport
MIC7113_RS27990	COG0515	serine threonine protein kinase
MIC7113_RS27990	COG3266	domain, Protein
MIC7113_RS27995	COG0515	serine threonine protein kinase
MIC7113_RS28000	COG0515	serine threonine protein kinase
MIC7113_RS28000	COG2815	serine threonine protein kinase
MIC7113_RS28005	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS28035	COG1028	Short-chain dehydrogenase reductase Sdr
MIC7113_RS28040	COG3631	Ketosteroid isomerase-related protein
MIC7113_RS28050	COG0693	protein deglycase activity
MIC7113_RS28075	COG4251	negative regulation of phosphorylation
MIC7113_RS28080	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MIC7113_RS28110	COG0484	heat shock protein binding
MIC7113_RS28125	COG0542	response to heat
MIC7113_RS28130	COG0456	acetyltransferase
MIC7113_RS28135	COG0019	diaminopimelate decarboxylase activity
MIC7113_RS28140	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MIC7113_RS28145	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MIC7113_RS28170	COG0493	'glutamate synthase
MIC7113_RS28170	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
MIC7113_RS28175	COG0617	tRNA 3'-terminal CCA addition
MIC7113_RS28185	COG0586	Pfam SNARE associated Golgi protein
MIC7113_RS28195	COG5001	Diguanylate cyclase
MIC7113_RS28195	COG4251	negative regulation of phosphorylation
MIC7113_RS28195	COG3706	GGDEF domain
MIC7113_RS28195	COG2203	Gaf domain
MIC7113_RS28200	COG1981	membrane
MIC7113_RS28210	COG2198	Histidine kinase
MIC7113_RS28210	COG0784	Response regulator, receiver
MIC7113_RS28210	COG0643	Histidine kinase
MIC7113_RS28220	COG2203	Gaf domain
MIC7113_RS28220	COG0840	transmembrane signaling receptor activity
MIC7113_RS28245	COG0709	Synthesizes selenophosphate from selenide and ATP
MIC7113_RS28255	COG0601	transmembrane transport
MIC7113_RS28275	COG0515	serine threonine protein kinase
MIC7113_RS28275	COG3266	domain, Protein
MIC7113_RS28295	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS28305	COG0071	Belongs to the small heat shock protein (HSP20) family
MIC7113_RS28355	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MIC7113_RS28435	COG0418	dihydroorotase activity
MIC7113_RS28455	COG2197	response regulator
MIC7113_RS28465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MIC7113_RS28490	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS28510	COG5002	protein histidine kinase activity
MIC7113_RS28515	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MIC7113_RS28520	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MIC7113_RS28530	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MIC7113_RS28535	COG2204	response regulator
MIC7113_RS28545	COG5002	protein histidine kinase activity
MIC7113_RS28555	COG2205	protein histidine kinase activity
MIC7113_RS28560	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MIC7113_RS28570	COG0515	serine threonine protein kinase
MIC7113_RS28595	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MIC7113_RS28600	COG0594	ribonuclease P activity
MIC7113_RS28610	COG0706	membrane insertase activity
MIC7113_RS28630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MIC7113_RS28640	COG0463	Glycosyl transferase, family 2
MIC7113_RS28650	COG1657	PFAM Prenyltransferase squalene oxidase
MIC7113_RS28675	COG2831	hemolysin activation secretion protein
MIC7113_RS28725	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MIC7113_RS28800	COG0137	argininosuccinate synthase activity
MIC7113_RS28820	COG2197	response regulator
MIC7113_RS28825	COG4191	Histidine kinase
MIC7113_RS28935	COG2321	neutral zinc metallopeptidase
MIC7113_RS28955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MIC7113_RS28965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MIC7113_RS28970	COG0564	pseudouridine synthase activity
MIC7113_RS28995	COG1672	PFAM Archaeal ATPase
MIC7113_RS28995	COG2319	Wd-40 repeat
MIC7113_RS29025	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MIC7113_RS29030	COG5001	Diguanylate cyclase
MIC7113_RS29030	COG1716	ATPase activity
MIC7113_RS29045	COG0793	Belongs to the peptidase S41A family
MIC7113_RS29050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MIC7113_RS29060	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS29090	COG0739	heme binding
MIC7113_RS29105	COG0628	permease
MIC7113_RS29125	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MIC7113_RS29130	COG0402	S-adenosylhomocysteine deaminase activity
MIC7113_RS29140	COG2124	cytochrome p450
MIC7113_RS29150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MIC7113_RS29155	COG1695	Transcriptional regulator
MIC7113_RS29160	COG0857	belongs to the CobB CobQ family
MIC7113_RS29180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MIC7113_RS29185	COG1802	Transcriptional regulator
MIC7113_RS29205	COG0222	ribosome binding
MIC7113_RS29240	COG1131	(ABC) transporter
MIC7113_RS29255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MIC7113_RS29295	COG0723	plastoquinol--plastocyanin reductase activity
MIC7113_RS29325	COG1192	Involved in chromosome partitioning
MIC7113_RS29330	COG0028	Belongs to the TPP enzyme family
MIC7113_RS29345	COG0628	permease
MIC7113_RS29370	COG5002	protein histidine kinase activity
MIC7113_RS29380	COG1027	Aspartate ammonia-lyase
MIC7113_RS29400	COG0596	Alpha beta hydrolase
MIC7113_RS29425	COG4572	Cation transport regulator
MIC7113_RS29435	COG0668	transmembrane transport
MIC7113_RS29485	COG3842	ATPase activity
MIC7113_RS29495	COG0783	Belongs to the Dps family
MIC7113_RS29500	COG0612	Peptidase, M16
MIC7113_RS29510	COG0612	Peptidase, M16
MIC7113_RS29525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MIC7113_RS29540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MIC7113_RS29545	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MIC7113_RS29550	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MIC7113_RS29555	COG0802	atpase or kinase
MIC7113_RS29560	COG3903	Transcriptional regulator
MIC7113_RS29560	COG2319	Wd-40 repeat
MIC7113_RS29575	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS29575	COG0515	serine threonine protein kinase
MIC7113_RS29580	COG0189	ligase activity
MIC7113_RS29585	COG4067	protein conserved in archaea
MIC7113_RS29585	COG0189	ligase activity
MIC7113_RS29595	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MIC7113_RS29615	COG0596	Alpha beta hydrolase
MIC7113_RS29645	COG2843	Capsule synthesis protein
MIC7113_RS29650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MIC7113_RS29655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MIC7113_RS29660	COG0572	uridine kinase
MIC7113_RS29720	COG1404	Belongs to the peptidase S8 family
MIC7113_RS29725	COG4249	Peptidase C14 caspase catalytic subunit p20
MIC7113_RS29725	COG2319	Wd-40 repeat
MIC7113_RS29745	COG0445	tRNA wobble uridine modification
MIC7113_RS29770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MIC7113_RS29775	COG0539	negative regulation of cytoplasmic translation
MIC7113_RS29785	COG1132	(ABC) transporter
MIC7113_RS29795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MIC7113_RS29800	COG0359	binds to the 23S rRNA
MIC7113_RS29805	COG0305	Participates in initiation and elongation during chromosome replication
MIC7113_RS29805	COG1372	Participates in initiation and elongation during chromosome replication
MIC7113_RS29805	COG0305	Participates in initiation and elongation during chromosome replication
MIC7113_RS29805	COG1372	Participates in initiation and elongation during chromosome replication
MIC7113_RS29830	COG5002	protein histidine kinase activity
MIC7113_RS29835	COG0151	Belongs to the GarS family
MIC7113_RS29840	COG0415	Belongs to the DNA photolyase family
MIC7113_RS29850	COG0494	nUDIX hydrolase
MIC7113_RS29855	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MIC7113_RS29860	COG0525	valine-tRNA ligase activity
MIC7113_RS29875	COG0515	serine threonine protein kinase
MIC7113_RS29875	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS29880	COG0515	serine threonine protein kinase
MIC7113_RS29880	COG3266	domain, Protein
MIC7113_RS29905	COG1104	cysteine desulfurase activity
MIC7113_RS29910	COG1530	ribonuclease E activity
MIC7113_RS29915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MIC7113_RS29930	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MIC7113_RS29935	COG0051	transcription antitermination factor activity, RNA binding
MIC7113_RS29940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MIC7113_RS29945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MIC7113_RS29955	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MIC7113_RS29960	COG0316	Belongs to the HesB IscA family
MIC7113_RS29975	COG0070	glutamate synthase
MIC7113_RS29975	COG0069	glutamate synthase activity
MIC7113_RS29975	COG0067	glutamate synthase
MIC7113_RS29990	COG0489	protein tyrosine kinase activity
MIC7113_RS30015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MIC7113_RS30020	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MIC7113_RS30030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MIC7113_RS30050	COG0217	transcriptional regulatory protein
MIC7113_RS30055	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS30070	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS30085	COG0837	glucose binding
MIC7113_RS30095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MIC7113_RS30105	COG1194	a g-specific adenine glycosylase
MIC7113_RS30110	COG2205	protein histidine kinase activity
MIC7113_RS30115	COG1543	Belongs to the glycosyl hydrolase 57 family
MIC7113_RS30175	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MIC7113_RS30185	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
MIC7113_RS30190	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MIC7113_RS30195	COG2203	Gaf domain
MIC7113_RS30195	COG4251	negative regulation of phosphorylation
MIC7113_RS30195	COG3706	GGDEF domain
MIC7113_RS30195	COG5001	Diguanylate cyclase
MIC7113_RS30200	COG2217	Heavy metal translocating P-type atpase
MIC7113_RS30215	COG4585	Histidine kinase
MIC7113_RS30220	COG2197	response regulator
MIC7113_RS30250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MIC7113_RS30260	COG3536	Protein conserved in bacteria
MIC7113_RS30265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MIC7113_RS30270	COG0556	nucleotide-excision repair
MIC7113_RS30300	COG3977	Valine--pyruvate aminotransferase
MIC7113_RS30330	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MIC7113_RS30335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MIC7113_RS30355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MIC7113_RS30375	COG3854	ATPases associated with a variety of cellular activities
MIC7113_RS30410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MIC7113_RS30415	COG0088	Forms part of the polypeptide exit tunnel
MIC7113_RS30420	COG0089	rRNA binding
MIC7113_RS30425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MIC7113_RS30430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MIC7113_RS30435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MIC7113_RS30440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MIC7113_RS30445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MIC7113_RS30450	COG0255	Belongs to the universal ribosomal protein uL29 family
MIC7113_RS30455	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MIC7113_RS30460	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MIC7113_RS30465	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MIC7113_RS30470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MIC7113_RS30475	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MIC7113_RS30480	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MIC7113_RS30485	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MIC7113_RS30490	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MIC7113_RS30495	COG0200	Binds to the 23S rRNA
MIC7113_RS30500	COG0201	protein transport
MIC7113_RS30505	COG0563	adenylate kinase activity
MIC7113_RS30510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MIC7113_RS30515	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MIC7113_RS30520	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MIC7113_RS30525	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MIC7113_RS30530	COG0202	RNA polymerase activity
MIC7113_RS30535	COG0203	ribosomal protein L17
MIC7113_RS30540	COG0101	tRNA pseudouridine synthase activity
MIC7113_RS30545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MIC7113_RS30550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MIC7113_RS30555	COG0254	rRNA binding
MIC7113_RS30560	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MIC7113_RS30580	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
MIC7113_RS30585	COG2211	Major facilitator Superfamily
MIC7113_RS30590	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MIC7113_RS30625	COG1695	Transcriptional regulator
MIC7113_RS30630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MIC7113_RS30640	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MIC7113_RS30645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MIC7113_RS30645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MIC7113_RS30680	COG2723	6-phospho-beta-galactosidase activity
MIC7113_RS30685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MIC7113_RS30695	COG0488	(ABC) transporter
MIC7113_RS30710	COG2066	Belongs to the glutaminase family
MIC7113_RS30725	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MIC7113_RS30730	COG0443	Heat shock 70 kDa protein
MIC7113_RS30735	COG0484	heat shock protein binding
MIC7113_RS30760	COG0018	arginyl-trna synthetase
MIC7113_RS30770	COG0242	peptide deformylase activity
MIC7113_RS30915	COG1475	DNA binding
MIC7113_RS30920	COG1192	Involved in chromosome partitioning
MIC7113_RS30965	COG4974	Belongs to the 'phage' integrase family
MIC7113_RS31000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MIC7113_RS31010	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MIC7113_RS31020	COG0515	serine threonine protein kinase
MIC7113_RS31020	COG2815	serine threonine protein kinase
MIC7113_RS31045	COG1061	Type III restriction enzyme res subunit
MIC7113_RS31070	COG0189	ligase activity
MIC7113_RS31085	COG2319	Wd-40 repeat
MIC7113_RS31085	COG4249	Peptidase C14 caspase catalytic subunit p20
MIC7113_RS31140	COG1205	dead DEAH box helicase
MIC7113_RS31140	COG1111	helicase
MIC7113_RS31170	COG0592	DNA-directed DNA polymerase activity
MIC7113_RS31315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MIC7113_RS31355	COG4974	Belongs to the 'phage' integrase family
MIC7113_RS31375	COG4115	mRNA cleavage
MIC7113_RS31380	COG2161	toxin-antitoxin pair type II binding
MIC7113_RS31445	COG1215	transferase activity, transferring glycosyl groups
MIC7113_RS31450	COG0784	Response regulator, receiver
MIC7113_RS31465	COG2203	Gaf domain
MIC7113_RS31465	COG0840	transmembrane signaling receptor activity
MIC7113_RS31470	COG0643	Histidine kinase
MIC7113_RS31470	COG2198	Histidine kinase
MIC7113_RS31470	COG0784	Response regulator, receiver
MIC7113_RS31530	COG0438	transferase activity, transferring glycosyl groups
MIC7113_RS31535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MIC7113_RS31560	COG1192	Involved in chromosome partitioning
MIC7113_RS31640	COG1091	dTDP-4-dehydrorhamnose reductase activity
MIC7113_RS31710	COG0489	protein tyrosine kinase activity
MIC7113_RS31940	COG1518	maintenance of DNA repeat elements
MIC7113_RS31940	COG1468	defense response to virus
MIC7113_RS31965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MIC7113_RS31975	COG0270	DNA (cytosine-5-)-methyltransferase activity
MIC7113_RS32045	COG2319	Wd-40 repeat
MIC7113_RS32045	COG1672	PFAM Archaeal ATPase
MIC7113_RS32050	COG1672	PFAM Archaeal ATPase
MIC7113_RS32050	COG2319	Wd-40 repeat
MIC7113_RS32130	COG1192	Involved in chromosome partitioning
MIC7113_RS32135	COG0367	asparagine synthase
MIC7113_RS32150	COG0071	Belongs to the small heat shock protein (HSP20) family
MIC7113_RS32155	COG4974	Belongs to the 'phage' integrase family
MIC7113_RS32185	COG2329	Antibiotic biosynthesis monooxygenase
MIC7113_RS32270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MIC7113_RS32290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MIC7113_RS32310	COG1032	radical SAM domain protein
MIC7113_RS32320	COG1192	Involved in chromosome partitioning
MIC7113_RS32430	COG1695	Transcriptional regulator
MIC7113_RS32440	COG1160	GTP binding
MIC7113_RS32445	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MIC7113_RS32465	COG0732	type I restriction modification DNA specificity domain
MIC7113_RS32475	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MIC7113_RS32500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MIC7113_RS32505	COG4974	Belongs to the 'phage' integrase family
MIC7113_RS32635	COG0720	synthase
MIC7113_RS32675	COG1694	Mazg nucleotide pyrophosphohydrolase
MIC7113_RS32720	COG1475	DNA binding
MIC7113_RS32725	COG1192	Involved in chromosome partitioning
MIC7113_RS32895	COG0515	serine threonine protein kinase
MIC7113_RS32930	COG4249	Peptidase C14 caspase catalytic subunit p20
MIC7113_RS32930	COG2319	Wd-40 repeat
MIC7113_RS32945	COG1672	PFAM Archaeal ATPase
MIC7113_RS32945	COG2319	Wd-40 repeat
MIC7113_RS32950	COG2319	Wd-40 repeat
MIC7113_RS32950	COG3903	Transcriptional regulator
MIC7113_RS32970	COG3447	MASE1 domain protein
MIC7113_RS32970	COG5001	Diguanylate cyclase
MIC7113_RS32970	COG5002	protein histidine kinase activity
MIC7113_RS32990	COG4191	Histidine kinase
MIC7113_RS33005	COG1994	Peptidase M50
MIC7113_RS33010	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS33010	COG0515	serine threonine protein kinase
MIC7113_RS33015	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS33015	COG0515	serine threonine protein kinase
MIC7113_RS33020	COG2198	Histidine kinase
MIC7113_RS33020	COG0784	Response regulator, receiver
MIC7113_RS33020	COG2205	protein histidine kinase activity
MIC7113_RS33025	COG2319	Wd-40 repeat
MIC7113_RS33025	COG4249	Peptidase C14 caspase catalytic subunit p20
MIC7113_RS33045	COG2203	Gaf domain
MIC7113_RS33045	COG3706	GGDEF domain
MIC7113_RS33045	COG4251	negative regulation of phosphorylation
MIC7113_RS33045	COG5001	Diguanylate cyclase
MIC7113_RS33050	COG2205	protein histidine kinase activity
MIC7113_RS33050	COG2198	Histidine kinase
MIC7113_RS33050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIC7113_RS33050	COG0784	Response regulator, receiver
MIC7113_RS33055	COG0848	biopolymer transport protein
MIC7113_RS33060	COG2205	protein histidine kinase activity
MIC7113_RS33065	COG5002	protein histidine kinase activity
MIC7113_RS33095	COG3659	wide pore channel activity
MIC7113_RS33140	COG1716	ATPase activity
MIC7113_RS33140	COG5001	Diguanylate cyclase
MIC7113_RS33150	COG5001	Diguanylate cyclase
MIC7113_RS33150	COG4251	negative regulation of phosphorylation
MIC7113_RS33150	COG2203	Gaf domain
MIC7113_RS33150	COG3706	GGDEF domain
MIC7113_RS33175	COG2815	serine threonine protein kinase
MIC7113_RS33175	COG0515	serine threonine protein kinase
MIC7113_RS33180	COG3292	Two component regulator propeller
MIC7113_RS33180	COG2205	protein histidine kinase activity
MIC7113_RS33180	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS33195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MIC7113_RS33215	COG0018	arginyl-trna synthetase
MIC7113_RS33220	COG5002	protein histidine kinase activity
MIC7113_RS33235	COG0784	Response regulator, receiver
MIC7113_RS33235	COG5002	protein histidine kinase activity
MIC7113_RS33235	COG2198	Histidine kinase
MIC7113_RS33240	COG2815	serine threonine protein kinase
MIC7113_RS33240	COG0515	serine threonine protein kinase
MIC7113_RS33270	COG5001	Diguanylate cyclase
MIC7113_RS33345	COG0784	Response regulator, receiver
MIC7113_RS33345	COG5002	protein histidine kinase activity
MIC7113_RS33360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MIC7113_RS33380	COG5002	protein histidine kinase activity
MIC7113_RS33425	COG3852	Histidine kinase
MIC7113_RS33475	COG2203	Gaf domain
MIC7113_RS33475	COG3706	GGDEF domain
MIC7113_RS33475	COG5001	Diguanylate cyclase
MIC7113_RS33475	COG4251	negative regulation of phosphorylation
MIC7113_RS33495	COG0732	type I restriction modification DNA specificity domain
MIC7113_RS33505	COG4251	negative regulation of phosphorylation
MIC7113_RS33510	COG5002	protein histidine kinase activity
MIC7113_RS33550	COG3852	Histidine kinase
MIC7113_RS33560	COG5002	protein histidine kinase activity
MIC7113_RS33560	COG0784	Response regulator, receiver
MIC7113_RS33560	COG2198	Histidine kinase
MIC7113_RS33580	COG0515	serine threonine protein kinase
MIC7113_RS33615	COG4251	negative regulation of phosphorylation
MIC7113_RS33630	COG5002	protein histidine kinase activity
MIC7113_RS33630	COG2198	Histidine kinase
MIC7113_RS33630	COG0784	Response regulator, receiver
MIC7113_RS33680	COG0463	Glycosyl transferase, family 2
MIC7113_RS33720	COG5002	protein histidine kinase activity
MIC7113_RS33720	COG3447	MASE1 domain protein
MIC7113_RS33720	COG5001	Diguanylate cyclase
MIC7113_RS33740	COG4191	Histidine kinase
MIC7113_RS33795	COG0457	Tetratricopeptide repeat
MIC7113_RS33795	COG0463	Glycosyl transferase, family 2
MIC7113_RS33820	COG3706	GGDEF domain
MIC7113_RS33820	COG4251	negative regulation of phosphorylation
MIC7113_RS33820	COG5001	Diguanylate cyclase
MIC7113_RS33820	COG2203	Gaf domain
MIC7113_RS33830	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS33880	COG3447	MASE1 domain protein
MIC7113_RS33880	COG5001	Diguanylate cyclase
MIC7113_RS33880	COG5002	protein histidine kinase activity
MIC7113_RS33910	COG1842	Phage shock protein A
MIC7113_RS33990	COG0515	serine threonine protein kinase
MIC7113_RS33990	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS34115	COG4249	Peptidase C14 caspase catalytic subunit p20
MIC7113_RS34115	COG2319	Wd-40 repeat
MIC7113_RS34335	COG2319	Wd-40 repeat
MIC7113_RS34335	COG3903	Transcriptional regulator
MIC7113_RS34415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MIC7113_RS34435	COG0739	heme binding
MIC7113_RS34595	COG0501	Belongs to the peptidase M48B family
MIC7113_RS34630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MIC7113_RS34660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MIC7113_RS34810	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MIC7113_RS34810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MIC7113_RS34925	COG2815	serine threonine protein kinase
MIC7113_RS34925	COG0515	serine threonine protein kinase
MIC7113_RS35070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MIC7113_RS35100	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
MIC7113_RS35170	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MIC7113_RS35210	COG1203	CRISPR-associated helicase, Cas3
MIC7113_RS35310	COG2205	protein histidine kinase activity
MIC7113_RS35310	COG0784	Response regulator, receiver
MIC7113_RS35400	COG2205	protein histidine kinase activity
MIC7113_RS35400	COG0784	Response regulator, receiver
MIC7113_RS35510	COG5001	Diguanylate cyclase
MIC7113_RS35510	COG4251	negative regulation of phosphorylation
MIC7113_RS35510	COG3706	GGDEF domain
MIC7113_RS35510	COG2203	Gaf domain
MIC7113_RS35755	COG2815	serine threonine protein kinase
MIC7113_RS35755	COG0515	serine threonine protein kinase
MIC7113_RS35890	COG0443	Heat shock 70 kDa protein
MIC7113_RS36015	COG5635	Nacht domain
MIC7113_RS36015	COG2319	Wd-40 repeat
MIC7113_RS36745	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MIC7113_RS36920	COG0514	ATP-dependent DNA helicase (RecQ)
MIC7113_RS37225	COG5001	Diguanylate cyclase
MIC7113_RS37225	COG5002	protein histidine kinase activity
MIC7113_RS37225	COG3447	MASE1 domain protein
MIC7113_RS37230	COG0745	RESPONSE REGULATOR receiver
MIC7113_RS37425	COG4251	negative regulation of phosphorylation
MIC7113_RS37460	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MIC7113_RS37580	COG1116	anion transmembrane transporter activity
MIC7113_RS37595	COG0515	serine threonine protein kinase
MIC7113_RS37595	COG2815	serine threonine protein kinase
MIC7113_RS37795	COG2084	Dehydrogenase
MIC7113_RS37845	COG5002	protein histidine kinase activity
MIC7113_RS37845	COG3850	Histidine kinase
MIC7113_RS37870	COG1357	PFAM Pentapeptide repeats (8 copies)
MIC7113_RS37870	COG0515	serine threonine protein kinase
MIC7113_RS37875	COG2897	thiosulfate sulfurtransferase activity
MIC7113_RS37880	COG2319	Wd-40 repeat
MIC7113_RS37880	COG1672	PFAM Archaeal ATPase
MIC7113_RS37965	COG3585	molybdate ion transport
MIC7113_RS38035	COG2202	Pas domain
MIC7113_RS38035	COG2205	protein histidine kinase activity
MIC7113_RS38060	COG4191	Histidine kinase
MIC7113_RS38115	COG0784	Response regulator, receiver
MIC7113_RS38115	COG2198	Histidine kinase
MIC7113_RS38115	COG0643	Histidine kinase
MIC7113_RS38115	COG0784	Response regulator, receiver
MIC7113_RS38115	COG2198	Histidine kinase
MIC7113_RS38115	COG0643	Histidine kinase
MIC7113_RS38125	COG4251	negative regulation of phosphorylation
MIC7113_RS38130	COG1132	(ABC) transporter
MIC7113_RS38200	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MIC7113_RS38415	COG2205	protein histidine kinase activity
MIC7113_RS38510	COG2201	protein-glutamate methylesterase activity
MIC7113_RS38850	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MIC7113_RS38855	COG2022	thiamine diphosphate biosynthetic process
MIC7113_RS38855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MIC7113_RS38860	COG2304	oxidoreductase activity
MIC7113_RS38870	COG1404	Belongs to the peptidase S8 family