locus-tag	class	description
E3E15_RS00010	COG0592	DNA-directed DNA polymerase activity
E3E15_RS00040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3E15_RS00045	COG0505	Belongs to the CarA family
E3E15_RS00055	COG0557	exoribonuclease II activity
E3E15_RS00090	COG1116	anion transmembrane transporter activity
E3E15_RS00105	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E3E15_RS00130	COG0762	integral membrane protein
E3E15_RS00135	COG1872	DUF167
E3E15_RS00145	COG0189	ligase activity
E3E15_RS00150	COG0658	competence protein
E3E15_RS00150	COG2333	competence protein COMEC
E3E15_RS00185	COG0531	amino acid
E3E15_RS00240	COG3328	transposase activity
E3E15_RS00255	COG3328	transposase activity
E3E15_RS00265	COG0814	amino acid
E3E15_RS00270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E3E15_RS00275	COG0531	amino acid
E3E15_RS00280	COG4178	(ABC) transporter
E3E15_RS00290	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E3E15_RS00295	COG0574	Belongs to the PEP-utilizing enzyme family
E3E15_RS00295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3E15_RS00300	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E3E15_RS00320	COG1560	Kdo2-lipid A biosynthetic process
E3E15_RS00325	COG1560	Kdo2-lipid A biosynthetic process
E3E15_RS00330	COG0706	membrane insertase activity
E3E15_RS00340	COG0594	ribonuclease P activity
E3E15_RS00350	COG0814	amino acid
E3E15_RS00355	COG0357	Ribosomal RNA small subunit methyltransferase G
E3E15_RS00360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E3E15_RS00365	COG2814	Major facilitator Superfamily
E3E15_RS00370	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E3E15_RS00405	COG0542	response to heat
E3E15_RS00440	COG0204	Acyl-transferase
E3E15_RS00450	COG0009	L-threonylcarbamoyladenylate synthase
E3E15_RS00490	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3E15_RS00500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E3E15_RS00505	COG2814	Major facilitator Superfamily
E3E15_RS00515	COG3328	transposase activity
E3E15_RS00535	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E3E15_RS00540	COG1538	Outer membrane efflux protein
E3E15_RS00550	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E3E15_RS00555	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3E15_RS00555	COG0047	phosphoribosylformylglycinamidine synthase activity
E3E15_RS00570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E3E15_RS00585	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3E15_RS00605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3E15_RS00615	COG3328	transposase activity
E3E15_RS00625	COG2814	Major facilitator Superfamily
E3E15_RS00650	COG0076	glutamate decarboxylase activity
E3E15_RS00660	COG0527	aspartate kinase activity
E3E15_RS00685	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3E15_RS00695	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3E15_RS00705	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E3E15_RS00715	COG1034	ATP synthesis coupled electron transport
E3E15_RS00725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3E15_RS00730	COG0839	Belongs to the complex I subunit 6 family
E3E15_RS00735	COG0713	ATP synthesis coupled electron transport
E3E15_RS00765	COG0606	chelatase, subunit chli
E3E15_RS00770	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E3E15_RS00785	COG2251	uridine kinase activity
E3E15_RS00785	COG0195	Participates in both transcription termination and antitermination
E3E15_RS00810	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E3E15_RS00815	COG0564	pseudouridine synthase activity
E3E15_RS00855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E3E15_RS00880	COG3328	transposase activity
E3E15_RS00910	COG0814	amino acid
E3E15_RS00915	COG3040	lipid binding
E3E15_RS00925	COG2066	Belongs to the glutaminase family
E3E15_RS00940	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E3E15_RS00945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E3E15_RS00950	COG1127	ABC transporter
E3E15_RS00955	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E3E15_RS00965	COG0850	regulation of cytokinetic process
E3E15_RS00985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E3E15_RS01005	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E3E15_RS01010	COG1051	belongs to the nudix hydrolase family
E3E15_RS01025	COG2252	PERMEase
E3E15_RS01030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3E15_RS01045	COG0477	Major facilitator Superfamily
E3E15_RS01065	COG1294	oxidase, subunit
E3E15_RS01070	COG1271	oxidase subunit
E3E15_RS01075	COG1090	epimerase
E3E15_RS01080	COG0642	Histidine kinase
E3E15_RS01100	COG3328	transposase activity
E3E15_RS01135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E3E15_RS01140	COG0459	protein refolding
E3E15_RS01150	COG1252	NADH dehydrogenase
E3E15_RS01160	COG0300	oxidoreductase activity
E3E15_RS01170	COG2081	HI0933 family
E3E15_RS01175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3E15_RS01180	COG0531	amino acid
E3E15_RS01205	COG0814	amino acid
E3E15_RS01220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3E15_RS01240	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E3E15_RS01245	COG0814	amino acid
E3E15_RS01325	COG0237	dephospho-CoA kinase activity
E3E15_RS01335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3E15_RS01350	COG2161	toxin-antitoxin pair type II binding
E3E15_RS01355	COG4115	mRNA cleavage
E3E15_RS01380	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3E15_RS01385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3E15_RS01410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E3E15_RS01410	COG0473	3-isopropylmalate dehydrogenase activity
E3E15_RS01425	COG2814	Major facilitator Superfamily
E3E15_RS01450	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3E15_RS01465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E3E15_RS01475	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3E15_RS01500	COG1183	phosphatidylcholine synthase activity
E3E15_RS01505	COG0142	geranyltranstransferase activity
E3E15_RS01510	COG1519	Transferase
E3E15_RS01515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E3E15_RS01520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E3E15_RS01525	COG0745	RESPONSE REGULATOR receiver
E3E15_RS01530	COG0681	Belongs to the peptidase S26 family
E3E15_RS01535	COG0571	ribonuclease III activity
E3E15_RS01545	COG0557	exoribonuclease II activity
E3E15_RS01570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E3E15_RS01585	COG5002	protein histidine kinase activity
E3E15_RS01590	COG0745	RESPONSE REGULATOR receiver
E3E15_RS01600	COG0010	Belongs to the arginase family
E3E15_RS01605	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E3E15_RS01635	COG0248	Ppx GppA phosphatase
E3E15_RS01640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3E15_RS01655	COG1994	Peptidase M50
E3E15_RS01660	COG1074	ATP-dependent DNA helicase activity
E3E15_RS01665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3E15_RS01690	COG1051	belongs to the nudix hydrolase family
E3E15_RS01690	COG1056	cytidyltransferase-related domain
E3E15_RS01700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E3E15_RS01775	COG1278	Cold shock
E3E15_RS01795	COG0772	Belongs to the SEDS family
E3E15_RS01830	COG0758	DNA mediated transformation
E3E15_RS01835	COG2885	chlorophyll binding
E3E15_RS01855	COG4401	Chorismate mutase type I
E3E15_RS01860	COG1183	phosphatidylcholine synthase activity
E3E15_RS01870	COG0811	peptide transport
E3E15_RS01915	COG0730	response to heat
E3E15_RS01940	COG0183	Belongs to the thiolase family
E3E15_RS01945	COG1024	Enoyl-CoA hydratase
E3E15_RS01945	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3E15_RS01950	COG1960	acyl-CoA dehydrogenase activity
E3E15_RS01955	COG0318	PFAM AMP-dependent synthetase and ligase
E3E15_RS01980	COG0488	(ABC) transporter
E3E15_RS02010	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E3E15_RS02015	COG0084	hydrolase, TatD family'
E3E15_RS02025	COG0730	response to heat
E3E15_RS02030	COG1131	(ABC) transporter
E3E15_RS02035	COG0842	Transport permease protein
E3E15_RS02040	COG0463	Glycosyl transferase, family 2
E3E15_RS02055	COG2996	Protein conserved in bacteria
E3E15_RS02060	COG1280	lysine exporter protein (LysE YggA)
E3E15_RS02065	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E3E15_RS02085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3E15_RS02090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3E15_RS02105	COG2983	Belongs to the UPF0260 family
E3E15_RS02130	COG0436	Aminotransferase
E3E15_RS02145	COG2166	iron-sulfur cluster assembly
E3E15_RS02220	COG0477	Major facilitator Superfamily
E3E15_RS02225	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E3E15_RS02230	COG2252	PERMEase
E3E15_RS02240	COG1028	Short-chain dehydrogenase reductase Sdr
E3E15_RS02245	COG4572	Cation transport regulator
E3E15_RS02260	COG2271	Major facilitator Superfamily
E3E15_RS02265	COG0251	oxidation-reduction process
E3E15_RS02275	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E3E15_RS02280	COG4988	ABC transporter
E3E15_RS02310	COG0436	Aminotransferase
E3E15_RS02320	COG0497	DNA recombination
E3E15_RS02325	COG3328	transposase activity
E3E15_RS02345	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E3E15_RS02350	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E3E15_RS02355	COG0247	lactate metabolic process
E3E15_RS02355	COG0277	FAD linked oxidase domain protein
E3E15_RS02370	COG0295	cytidine deaminase activity
E3E15_RS02395	COG2860	membrane
E3E15_RS02400	COG0742	ribosomal rna small subunit methyltransferase
E3E15_RS02410	COG0612	Peptidase, M16
E3E15_RS02415	COG0795	lipopolysaccharide-transporting ATPase activity
E3E15_RS02420	COG0795	lipopolysaccharide-transporting ATPase activity
E3E15_RS02430	COG0517	IMP dehydrogenase activity
E3E15_RS02430	COG0516	GMP reductase activity
E3E15_RS02445	COG4969	Belongs to the N-Me-Phe pilin family
E3E15_RS02455	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E3E15_RS02460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3E15_RS02480	COG3328	transposase activity
E3E15_RS02500	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E3E15_RS02515	COG1177	transmembrane transport
E3E15_RS02520	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3E15_RS02525	COG3842	ATPase activity
E3E15_RS02560	COG0531	amino acid
E3E15_RS02575	COG0077	Prephenate dehydratase
E3E15_RS02575	COG1605	Chorismate mutase
E3E15_RS02580	COG0737	Belongs to the 5'-nucleotidase family
E3E15_RS02590	COG1760	l-serine dehydratase
E3E15_RS02595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3E15_RS02600	COG0316	Belongs to the HesB IscA family
E3E15_RS02605	COG2151	metal-sulfur cluster biosynthetic enzyme
E3E15_RS02615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3E15_RS02655	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E3E15_RS02665	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E3E15_RS02680	COG0445	tRNA wobble uridine modification
E3E15_RS02700	COG2925	Exonuclease
E3E15_RS02705	COG0556	nucleotide-excision repair
E3E15_RS02735	COG1137	ATPase activity
E3E15_RS02740	COG0179	Fumarylacetoacetate (FAA) hydrolase
E3E15_RS02745	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E3E15_RS02770	COG0095	Lipoate-protein ligase
E3E15_RS02775	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E3E15_RS02805	COG2337	Toxic component of a toxin-antitoxin (TA) module
E3E15_RS02825	COG0142	geranyltranstransferase activity
E3E15_RS02845	COG0037	tRNA processing
E3E15_RS02880	COG0583	DNA-binding transcription factor activity
E3E15_RS02915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3E15_RS02920	COG0475	glutathione-regulated potassium exporter activity
E3E15_RS02920	COG0589	response to stress
E3E15_RS02925	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E3E15_RS02940	COG0509	glycine decarboxylation via glycine cleavage system
E3E15_RS02950	COG0024	Methionine aminopeptidase
E3E15_RS02960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3E15_RS02965	COG3328	transposase activity
E3E15_RS02980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E3E15_RS02985	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E3E15_RS02990	COG0587	DNA-directed DNA polymerase activity
E3E15_RS02995	COG2974	May be involved in recombination
E3E15_RS03000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3E15_RS03045	COG3328	transposase activity
E3E15_RS03065	COG1982	Orn Lys Arg decarboxylase major
E3E15_RS03070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E3E15_RS03075	COG0509	glycine decarboxylation via glycine cleavage system
E3E15_RS03080	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E3E15_RS03085	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E3E15_RS03095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3E15_RS03110	COG2814	Major facilitator Superfamily
E3E15_RS03145	COG3079	Belongs to the UPF0149 family
E3E15_RS03150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3E15_RS03155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3E15_RS03165	COG0561	phosphatase activity
E3E15_RS03175	COG1335	isochorismatase
E3E15_RS03185	COG0697	spore germination
E3E15_RS03190	COG0354	folic acid binding
E3E15_RS03195	COG0210	DNA helicase
E3E15_RS03210	COG2814	Major facilitator Superfamily
E3E15_RS03235	COG3328	transposase activity
E3E15_RS03245	COG0659	secondary active sulfate transmembrane transporter activity
E3E15_RS03260	COG0488	(ABC) transporter
E3E15_RS03265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3E15_RS03270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3E15_RS03280	COG0517	IMP dehydrogenase activity
E3E15_RS03295	COG2814	Major facilitator Superfamily
E3E15_RS03315	COG0799	negative regulation of ribosome biogenesis
E3E15_RS03325	COG0210	DNA helicase
E3E15_RS03345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3E15_RS03350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3E15_RS03370	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E3E15_RS03380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3E15_RS03390	COG0450	alkyl hydroperoxide reductase
E3E15_RS03400	COG2824	Alkylphosphonate utilization operon protein PhnA
E3E15_RS03410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3E15_RS03430	COG1012	belongs to the aldehyde dehydrogenase family
E3E15_RS03445	COG1610	YqeY-like protein
E3E15_RS03450	COG0358	DNA primase activity
E3E15_RS03455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3E15_RS03465	COG4536	flavin adenine dinucleotide binding
E3E15_RS03470	COG0110	maltose O-acetyltransferase activity
E3E15_RS03475	COG0012	GTP binding
E3E15_RS03480	COG0193	aminoacyl-tRNA hydrolase activity
E3E15_RS03495	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E3E15_RS03500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3E15_RS03510	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E3E15_RS03515	COG1773	rubredoxin
E3E15_RS03540	COG2999	glutathione oxidoreductase activity
E3E15_RS03545	COG2878	Part of a membrane complex involved in electron transport
E3E15_RS03550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3E15_RS03570	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E3E15_RS03595	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E3E15_RS03600	COG0217	transcriptional regulatory protein
E3E15_RS03615	COG3328	transposase activity
E3E15_RS03620	COG0632	four-way junction helicase activity
E3E15_RS03630	COG1509	lysine 2,3-aminomutase activity
E3E15_RS03635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E3E15_RS03650	COG0277	FAD linked oxidase domain protein
E3E15_RS03655	COG0563	adenylate kinase activity
E3E15_RS03685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E3E15_RS03700	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E3E15_RS03715	COG3328	transposase activity
E3E15_RS03720	COG0531	amino acid
E3E15_RS03725	COG2814	Major facilitator Superfamily
E3E15_RS03730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3E15_RS03735	COG3328	transposase activity
E3E15_RS03740	COG0415	Belongs to the DNA photolyase family
E3E15_RS03755	COG2264	protein methyltransferase activity
E3E15_RS03770	COG0077	Prephenate dehydratase
E3E15_RS03770	COG1605	Chorismate mutase
E3E15_RS03775	COG0386	Belongs to the glutathione peroxidase family
E3E15_RS03780	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E3E15_RS03780	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E3E15_RS03810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3E15_RS03820	COG0531	amino acid
E3E15_RS03825	COG0569	domain protein
E3E15_RS03830	COG1959	2 iron, 2 sulfur cluster binding
E3E15_RS03835	COG0719	Fe-S assembly protein
E3E15_RS03840	COG0396	ATPase activity
E3E15_RS03845	COG0719	Fe-S assembly protein
E3E15_RS03895	COG0494	nUDIX hydrolase
E3E15_RS03900	COG1678	Uncharacterized ACR, COG1678
E3E15_RS03905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E3E15_RS03920	COG0668	transmembrane transport
E3E15_RS03930	COG0489	protein tyrosine kinase activity
E3E15_RS03940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3E15_RS03940	COG0072	phenylalanine-tRNA ligase activity
E3E15_RS03960	COG3104	oligopeptide transport
E3E15_RS03965	COG0246	Mannitol dehydrogenase
E3E15_RS03985	COG1904	glucuronate isomerase
E3E15_RS03990	COG2814	Major facilitator Superfamily
E3E15_RS04000	COG2255	four-way junction helicase activity
E3E15_RS04020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E3E15_RS04025	COG1472	Belongs to the glycosyl hydrolase 3 family
E3E15_RS04040	COG3328	transposase activity
E3E15_RS04045	COG0513	Belongs to the DEAD box helicase family
E3E15_RS04050	COG0302	gtp cyclohydrolase
E3E15_RS04060	COG0667	Aldo Keto reductase
E3E15_RS04075	COG0512	Glutamine amidotransferase of anthranilate synthase
E3E15_RS04075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3E15_RS04080	COG0318	PFAM AMP-dependent synthetase and ligase
E3E15_RS04095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E3E15_RS04095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3E15_RS04105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E3E15_RS04110	COG0189	ligase activity
E3E15_RS04115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E3E15_RS04145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E3E15_RS04180	COG0730	response to heat
E3E15_RS04190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3E15_RS04195	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3E15_RS04205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3E15_RS04205	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E3E15_RS04210	COG2914	Belongs to the UPF0125 (RnfH) family
E3E15_RS04215	COG2867	negative regulation of translational initiation
E3E15_RS04225	COG0037	tRNA processing
E3E15_RS04235	COG0708	Exodeoxyribonuclease III
E3E15_RS04245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3E15_RS04265	COG1570	exodeoxyribonuclease VII activity
E3E15_RS04270	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E3E15_RS04275	COG1686	Belongs to the peptidase S11 family
E3E15_RS04280	COG2921	Belongs to the UPF0250 family
E3E15_RS04300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E3E15_RS04310	COG1214	PFAM Peptidase M22, glycoprotease
E3E15_RS04315	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3E15_RS04320	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E3E15_RS04330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3E15_RS04345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E3E15_RS04370	COG1702	phosphate starvation-inducible protein PhoH
E3E15_RS04385	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E3E15_RS04400	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E3E15_RS04405	COG2814	Major facilitator Superfamily
E3E15_RS04410	COG0751	glycine-tRNA ligase activity
E3E15_RS04415	COG0084	hydrolase, TatD family'
E3E15_RS04420	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E3E15_RS04440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3E15_RS04450	COG0586	Pfam SNARE associated Golgi protein
E3E15_RS04455	COG0586	Pfam SNARE associated Golgi protein
E3E15_RS04475	COG1530	ribonuclease E activity
E3E15_RS04485	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E3E15_RS04490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3E15_RS04500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E3E15_RS04510	COG0156	8-amino-7-oxononanoate synthase activity
E3E15_RS04515	COG4106	trans-aconitate 2-methyltransferase activity
E3E15_RS04525	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E3E15_RS04525	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E3E15_RS04590	COG0513	Belongs to the DEAD box helicase family
E3E15_RS04595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3E15_RS04610	COG2835	tetraacyldisaccharide 4'-kinase activity
E3E15_RS04620	COG0482	sulfurtransferase activity
E3E15_RS04630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3E15_RS04635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E3E15_RS04640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E3E15_RS04655	COG0436	Aminotransferase
E3E15_RS04670	COG1187	pseudouridine synthase activity
E3E15_RS04690	COG0359	binds to the 23S rRNA
E3E15_RS04695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E3E15_RS04700	COG0360	Binds together with S18 to 16S ribosomal RNA
E3E15_RS04705	COG0408	coproporphyrinogen oxidase activity
E3E15_RS04715	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E3E15_RS04720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E3E15_RS04750	COG1446	asparaginase
E3E15_RS04760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3E15_RS04770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3E15_RS04775	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E3E15_RS04775	COG0517	IMP dehydrogenase activity
E3E15_RS04785	COG1611	Belongs to the LOG family
E3E15_RS04800	COG0346	lactoylglutathione lyase activity
E3E15_RS04805	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E3E15_RS04815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3E15_RS04820	COG0330	HflC and HflK could
E3E15_RS04825	COG0330	HflC and HflK could
E3E15_RS04830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3E15_RS04835	COG1923	regulation of RNA biosynthetic process
E3E15_RS04855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E3E15_RS04860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E3E15_RS04865	COG0740	serine-type endopeptidase activity
E3E15_RS04880	COG0288	reversible hydration of carbon dioxide
E3E15_RS04885	COG0252	asparaginase activity
E3E15_RS04905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3E15_RS04915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3E15_RS04920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3E15_RS04925	COG1862	Preprotein translocase
E3E15_RS04950	COG1464	Belongs to the NlpA lipoprotein family
E3E15_RS04970	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3E15_RS04970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3E15_RS04975	COG0189	ligase activity
E3E15_RS04975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3E15_RS04980	COG1058	Belongs to the CinA family
E3E15_RS04980	COG1546	Belongs to the CinA family
E3E15_RS04990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3E15_RS05015	COG2855	membrane
E3E15_RS05020	COG0483	inositol monophosphate 1-phosphatase activity
E3E15_RS05065	COG0156	8-amino-7-oxononanoate synthase activity
E3E15_RS05075	COG0814	amino acid
E3E15_RS05080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E3E15_RS05085	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E3E15_RS05115	COG1758	RNA polymerase activity
E3E15_RS05120	COG0572	uridine kinase
E3E15_RS05140	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E3E15_RS05150	COG3116	cell division
E3E15_RS05155	COG0275	rRNA processing
E3E15_RS05160	COG0204	Acyl-transferase
E3E15_RS05160	COG0318	PFAM AMP-dependent synthetase and ligase
E3E15_RS05165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3E15_RS05180	COG3328	transposase activity
E3E15_RS05190	COG0492	ferredoxin-NADP+ reductase activity
E3E15_RS05225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3E15_RS05235	COG0187	DNA topoisomerase II activity
E3E15_RS05245	COG3328	transposase activity
E3E15_RS05250	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E3E15_RS05260	COG1162	GTPase activity
E3E15_RS05275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3E15_RS05285	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E3E15_RS05290	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E3E15_RS05300	COG0439	Biotin carboxylase
E3E15_RS05310	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E3E15_RS05320	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3E15_RS05330	COG0531	amino acid
E3E15_RS05335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E3E15_RS05350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3E15_RS05355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E3E15_RS05360	COG0113	porphobilinogen synthase activity
E3E15_RS05365	COG1534	Rna-binding protein
E3E15_RS05370	COG0470	DNA polymerase III
E3E15_RS05375	COG0616	signal peptide processing
E3E15_RS05380	COG0625	glutathione transferase activity
E3E15_RS05385	COG2920	part of a sulfur-relay system
E3E15_RS05390	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E3E15_RS05400	COG0671	phosphoesterase, PA-phosphatase related
E3E15_RS05435	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E3E15_RS05445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E3E15_RS05465	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E3E15_RS05465	COG0662	Cupin 2, conserved barrel domain protein
E3E15_RS05480	COG0586	Pfam SNARE associated Golgi protein
E3E15_RS05510	COG0583	DNA-binding transcription factor activity
E3E15_RS05520	COG0501	Belongs to the peptidase M48B family
E3E15_RS05555	COG4115	mRNA cleavage
E3E15_RS05560	COG2161	toxin-antitoxin pair type II binding
E3E15_RS05565	COG3177	Filamentation induced by cAMP protein fic
E3E15_RS05620	COG0662	Cupin 2, conserved barrel domain protein
E3E15_RS05620	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E3E15_RS05630	COG1216	Glycosyl transferase, family 2
E3E15_RS05635	COG0463	Glycosyl transferase, family 2
E3E15_RS05645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3E15_RS05670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3E15_RS05675	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E3E15_RS05680	COG0438	transferase activity, transferring glycosyl groups
E3E15_RS05690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3E15_RS05740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3E15_RS05750	COG1086	Polysaccharide biosynthesis protein
E3E15_RS05755	COG1643	Atp-dependent helicase
E3E15_RS05775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3E15_RS05780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3E15_RS05790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E3E15_RS05800	COG3328	transposase activity
E3E15_RS05805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3E15_RS05820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3E15_RS05825	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E3E15_RS05830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3E15_RS05835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3E15_RS05840	COG1028	Short-chain dehydrogenase reductase Sdr
E3E15_RS05845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E3E15_RS05860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E3E15_RS05880	COG0126	phosphoglycerate kinase activity
E3E15_RS05885	COG0469	pyruvate kinase activity
E3E15_RS05890	COG0191	fructose-bisphosphate aldolase activity
E3E15_RS05895	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3E15_RS05905	COG2992	FlgJ-related protein
E3E15_RS05910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E3E15_RS05915	COG1127	ABC transporter
E3E15_RS05935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E3E15_RS05940	COG3104	oligopeptide transport
E3E15_RS05950	COG0318	PFAM AMP-dependent synthetase and ligase
E3E15_RS05955	COG0477	Major facilitator Superfamily
E3E15_RS05960	COG1566	PFAM secretion protein HlyD family protein
E3E15_RS05980	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E3E15_RS05990	COG0443	Heat shock 70 kDa protein
E3E15_RS05995	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E3E15_RS06010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E3E15_RS06045	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E3E15_RS06085	COG3093	addiction module antidote protein HigA
E3E15_RS06090	COG3549	Plasmid maintenance system killer
E3E15_RS06105	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E3E15_RS06180	COG2271	Major facilitator Superfamily
E3E15_RS06185	COG0009	L-threonylcarbamoyladenylate synthase
E3E15_RS06195	COG0837	glucose binding
E3E15_RS06200	COG2226	methyltransferase
E3E15_RS06210	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E3E15_RS06215	COG0537	adenosine 5'-monophosphoramidase activity
E3E15_RS06220	COG1040	competence protein
E3E15_RS06225	COG4106	trans-aconitate 2-methyltransferase activity
E3E15_RS06235	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E3E15_RS06240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E3E15_RS06245	COG1160	GTP binding
E3E15_RS06265	COG0281	malic enzyme
E3E15_RS06270	COG0196	riboflavin kinase activity
E3E15_RS06300	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E3E15_RS06310	COG0519	Catalyzes the synthesis of GMP from XMP
E3E15_RS06310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3E15_RS06315	COG1475	DNA binding
E3E15_RS06320	COG1192	Involved in chromosome partitioning
E3E15_RS06350	COG0339	signal peptide processing
E3E15_RS06355	COG0792	nuclease activity
E3E15_RS06370	COG2890	protein-(glutamine-N5) methyltransferase activity
E3E15_RS06390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3E15_RS06395	COG2814	Major facilitator Superfamily
E3E15_RS06410	COG3023	N-Acetylmuramoyl-L-alanine amidase
E3E15_RS06435	COG4974	Belongs to the 'phage' integrase family
E3E15_RS06445	COG0336	Belongs to the RNA methyltransferase TrmD family
E3E15_RS06460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E3E15_RS06470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E3E15_RS06500	COG0081	regulation of translation
E3E15_RS06505	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E3E15_RS06515	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3E15_RS06525	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E3E15_RS06555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E3E15_RS06575	COG0210	DNA helicase
E3E15_RS06580	COG0552	protein localization to endoplasmic reticulum
E3E15_RS06600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3E15_RS06605	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E3E15_RS06610	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E3E15_RS06620	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3E15_RS06620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3E15_RS06640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E3E15_RS06645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3E15_RS06650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3E15_RS06685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E3E15_RS06710	COG2890	protein-(glutamine-N5) methyltransferase activity
E3E15_RS06745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3E15_RS06750	COG1494	fructose-1,6-bisphosphatase
E3E15_RS06755	COG2945	thiolester hydrolase activity
E3E15_RS06760	COG0833	amino acid
E3E15_RS06770	COG1674	ftsk spoiiie
E3E15_RS06790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3E15_RS06820	COG3328	transposase activity
E3E15_RS06835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E3E15_RS06845	COG2918	glutathione biosynthetic process
E3E15_RS06850	COG0728	peptidoglycan biosynthetic process
E3E15_RS06860	COG0802	atpase or kinase
E3E15_RS06865	COG0285	dihydrofolate synthase activity
E3E15_RS06870	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E3E15_RS06915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E3E15_RS06925	COG0201	protein transport
E3E15_RS06945	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E3E15_RS06955	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E3E15_RS06960	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E3E15_RS06980	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E3E15_RS06990	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E3E15_RS07000	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E3E15_RS07005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E3E15_RS07010	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E3E15_RS07040	COG0049	tRNA binding
E3E15_RS07050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3E15_RS07060	COG4589	Belongs to the CDS family
E3E15_RS07065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3E15_RS07085	COG0052	Belongs to the universal ribosomal protein uS2 family
E3E15_RS07090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E3E15_RS07095	COG2814	Major facilitator Superfamily
E3E15_RS07100	COG1271	oxidase subunit
E3E15_RS07105	COG1294	oxidase, subunit
E3E15_RS07125	COG3328	transposase activity
E3E15_RS07150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3E15_RS07160	COG1295	ribonuclease BN
E3E15_RS07185	COG3842	ATPase activity
E3E15_RS07190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3E15_RS07210	COG0138	bifunctional purine biosynthesis protein purh
E3E15_RS07245	COG0488	(ABC) transporter
E3E15_RS07250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3E15_RS07255	COG0477	Major facilitator Superfamily
E3E15_RS07260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3E15_RS07270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E3E15_RS07280	COG0629	single-stranded DNA binding
E3E15_RS07285	COG3328	transposase activity
E3E15_RS07300	COG0280	phosphate acetyltransferase
E3E15_RS07300	COG0857	belongs to the CobB CobQ family
E3E15_RS07305	COG1012	belongs to the aldehyde dehydrogenase family
E3E15_RS07325	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E3E15_RS07330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3E15_RS07380	COG0135	phosphoribosylanthranilate isomerase activity
E3E15_RS07380	COG0134	indole-3-glycerol-phosphate synthase activity
E3E15_RS07385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E3E15_RS07390	COG0284	orotidine-5'-phosphate decarboxylase activity
E3E15_RS07395	COG0167	dihydroorotate dehydrogenase activity
E3E15_RS07405	COG3328	transposase activity
E3E15_RS07480	COG1605	Chorismate mutase
E3E15_RS07480	COG0287	Prephenate dehydrogenase
E3E15_RS07485	COG1490	D-aminoacyl-tRNA deacylase activity
E3E15_RS07500	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E3E15_RS07525	COG3328	transposase activity
E3E15_RS07540	COG3411	Ferredoxin
E3E15_RS07545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3E15_RS07545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3E15_RS07550	COG0307	riboflavin synthase, alpha
E3E15_RS07565	COG0242	peptide deformylase activity
E3E15_RS07580	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E3E15_RS07605	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E3E15_RS07615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3E15_RS07630	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3E15_RS07660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3E15_RS07665	COG1053	succinate dehydrogenase
E3E15_RS07670	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E3E15_RS07675	COG2009	succinate dehydrogenase
E3E15_RS07685	COG2223	nitrite transmembrane transporter activity
E3E15_RS07690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E3E15_RS07695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E3E15_RS07705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E3E15_RS07765	COG3328	transposase activity
E3E15_RS07770	COG0589	response to stress
E3E15_RS07785	COG0714	Associated with various cellular activities
E3E15_RS07805	COG2304	oxidoreductase activity
E3E15_RS07835	COG0525	valine-tRNA ligase activity
E3E15_RS07840	COG3328	transposase activity
E3E15_RS07850	COG0512	Glutamine amidotransferase of anthranilate synthase
E3E15_RS07855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3E15_RS07875	COG1530	ribonuclease E activity