locus-tag	class	description
E4K63_RS00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
E4K63_RS00035	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
E4K63_RS00045	ENOG4107ZUJ	lipid metabolic process
E4K63_RS00105	ENOG4108Z0R	Transferase
E4K63_RS00130	ENOG4108VIA	integral membrane protein
E4K63_RS00135	ENOG4105VZ9	UPF0235 protein
E4K63_RS00145	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
E4K63_RS00185	ENOG4108BUD	transposase
E4K63_RS00195	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
E4K63_RS00210	ENOG4105CMQ	Chloride channel
E4K63_RS00230	ENOG4107QTZ	amino acid
E4K63_RS00300	ENOG4105E0U	tyrosine-specific transport protein
E4K63_RS00305	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4K63_RS00310	ENOG4105C0X	amino acid
E4K63_RS00315	ENOG4105CQ0	ABC transporter
E4K63_RS00320	ENOG4105C9M	aspartyl-trna synthetase
E4K63_RS00330	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
E4K63_RS00335	ENOG4105CE1	Ferrous iron transport protein b
E4K63_RS00355	ENOG4105D1S	lipid A biosynthesis
E4K63_RS00360	ENOG4105D1S	lipid A biosynthesis
E4K63_RS00365	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
E4K63_RS00375	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
E4K63_RS00385	ENOG4105E0U	tyrosine-specific transport protein
E4K63_RS00390	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
E4K63_RS00395	ENOG4105DFA	alanine racemase domain protein
E4K63_RS00400	ENOG4105HEI	LysR family (Transcriptional regulator
E4K63_RS00405	ENOG4105C2C	drug resistance transporter, Bcr CflA
E4K63_RS00410	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
E4K63_RS00415	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
E4K63_RS00445	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E4K63_RS00475	ENOG4106HNH	Acyl-transferase
E4K63_RS00485	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E4K63_RS00490	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
E4K63_RS00495	ENOG4108Z6B	deaminase
E4K63_RS00510	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
E4K63_RS00515	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
E4K63_RS00525	ENOG4107QMP	dna polymerase iii subunits gamma and tau
E4K63_RS00550	ENOG4105DN9	Na H antiporter
E4K63_RS00570	ENOG4105CFP	Peptidase U32
E4K63_RS00575	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
E4K63_RS00580	ENOG4105DFG	type I secretion outer membrane protein
E4K63_RS00590	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
E4K63_RS00595	ENOG4108ETH	Formylglycinamide ribotide synthetase
E4K63_RS00600	ENOG4105C83	adenylosuccinate lyase
E4K63_RS00615	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
E4K63_RS00620	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
E4K63_RS00630	ENOG4108BUD	transposase
E4K63_RS00640	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
E4K63_RS00645	ENOG4105EYM	Major Facilitator superfamily
E4K63_RS00670	ENOG4105DY8	decarboxylase
E4K63_RS00680	ENOG4105CFH	Aspartokinase
E4K63_RS00705	ENOG41090R7	Ferric uptake
E4K63_RS00710	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E4K63_RS00720	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E4K63_RS00730	ENOG4105GKE	subunit e
E4K63_RS00735	ENOG4107QIZ	NADH dehydrogenase
E4K63_RS00740	ENOG4108IEH	NADH dehydrogenase subunit g
E4K63_RS00750	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E4K63_RS00755	ENOG4105DF2	NADH dehydrogenase subunit j
E4K63_RS00770	ENOG4105C8S	subunit m
E4K63_RS00780	ENOG4105W0Z	cytoplasmic protein
E4K63_RS00785	ENOG4105C0P	Mg chelatase subunit ChlI
E4K63_RS00790	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
E4K63_RS00805	ENOG4105CHV	Transcription elongation factor NusA
E4K63_RS00830	ENOG4105D6Z	AFG1 family ATPase
E4K63_RS00835	ENOG4105EI2	Pseudouridine synthase
E4K63_RS00865	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E4K63_RS00885	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
E4K63_RS00940	ENOG4105C44	Serine transporter
E4K63_RS00945	ENOG4105QNF	Outer membrane lipoprotein
E4K63_RS00955	ENOG4105CSV	Glutaminase
E4K63_RS00960	ENOG4107R5B	glutamine synthetase
E4K63_RS00970	ENOG4107PE3	Mammalian cell entry related domain protein
E4K63_RS00975	ENOG4105CY3	ABC transporter, permease
E4K63_RS00980	ENOG4105DHJ	ABC, transporter
E4K63_RS00990	ENOG4107QMS	site-determining protein
E4K63_RS00995	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
E4K63_RS01015	ENOG4105CB5	ATP-dependent DNA helicase recG
E4K63_RS01040	ENOG4107GFK	fumarate
E4K63_RS01055	ENOG4105C7N	Xanthine uracil vitamin C permease
E4K63_RS01060	ENOG4105CSA	Coproporphyrinogen iii oxidase
E4K63_RS01080	ENOG4108I0Z	Aconitate hydratase
E4K63_RS01090	ENOG4105CZX	twitching motility protein
E4K63_RS01095	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
E4K63_RS01100	ENOG4105C4M	(Ubiquinol oxidase) subunit I
E4K63_RS01105	ENOG4105DHQ	Histidine kinase
E4K63_RS01135	ENOG4105BZS	acriflavin resistance protein
E4K63_RS01140	ENOG410624X	efflux transporter, rnd family, mfp subunit
E4K63_RS01145	ENOG4105RXK	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
E4K63_RS01165	ENOG4105C2M	dna polymerase I
E4K63_RS01175	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
E4K63_RS01180	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
E4K63_RS01185	ENOG4105D9N	nucleoside
E4K63_RS01205	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
E4K63_RS01215	ENOG4105C4R	Atp-dependent dna helicase
E4K63_RS01220	ENOG4105DJB	Major Facilitator Superfamily
E4K63_RS01235	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
E4K63_RS01245	ENOG4105D64	Mechanosensitive ion channel
E4K63_RS01265	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
E4K63_RS01275	ENOG4105PM1	preprotein translocase subunit SecE
E4K63_RS01280	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
E4K63_RS01285	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
E4K63_RS01290	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
E4K63_RS01320	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E4K63_RS01330	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
E4K63_RS01345	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
E4K63_RS01355	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E4K63_RS01375	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
E4K63_RS01390	ENOG4105C2C	drug resistance transporter, Bcr CflA
E4K63_RS01395	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
E4K63_RS01415	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
E4K63_RS01430	ENOG41082RQ	UPF0102 protein
E4K63_RS01435	ENOG4105DGW	oligopeptidase A
E4K63_RS01480	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
E4K63_RS01495	ENOG4105C11	sulfate adenylyltransferase), subunit 2
E4K63_RS01515	ENOG4105BZ1	(ABC) transporter
E4K63_RS01530	ENOG4105CAQ	asparagine synthetase
E4K63_RS01565	ENOG4107QJE	Chromosome Partitioning Protein
E4K63_RS01570	ENOG4105FA0	parb-like partition protein
E4K63_RS01575	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E4K63_RS01615	ENOG4105DTN	riboflavin biosynthesis protein ribF
E4K63_RS01620	ENOG4107R1I	NAD-dependent malic enzyme
E4K63_RS01635	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
E4K63_RS01640	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
E4K63_RS01645	ENOG4105D4A	Cell wall formation (By similarity)
E4K63_RS01660	ENOG4105MJ2	Competence protein
E4K63_RS01665	ENOG4107YU2	histidine triad (hIT) protein
E4K63_RS01670	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
E4K63_RS01680	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
E4K63_RS01690	ENOG4105CHC	glucokinase (EC 2.7.1.2)
E4K63_RS01700	ENOG4107835	probably involved in intracellular septation (By similarity)
E4K63_RS01705	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
E4K63_RS01710	ENOG4108I5G	Major Facilitator superfamily
E4K63_RS01785	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
E4K63_RS01815	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
E4K63_RS01830	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E4K63_RS01840	ENOG4107MKT	Stringent starvation protein a
E4K63_RS01845	ENOG4108UJD	30S ribosomal protein S9
E4K63_RS01850	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
E4K63_RS01865	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4K63_RS01870	ENOG4105CFG	Acts as a chaperone (By similarity)
E4K63_RS01875	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E4K63_RS01925	ENOG4105C4K	Nad synthetase
E4K63_RS01955	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
E4K63_RS01960	ENOG4105CEY	Amp-dependent synthetase and ligase
E4K63_RS01970	ENOG4105DUX	Transporter
E4K63_RS01995	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
E4K63_RS02005	ENOG4108UR8	BAX protein
E4K63_RS02015	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4K63_RS02020	ENOG4105D2N	Aldolase
E4K63_RS02025	ENOG4105CA9	Pyruvate kinase
E4K63_RS02030	ENOG4105BZA	Phosphoglycerate kinase
E4K63_RS02040	ENOG4105CV1	Transketolase (EC 2.2.1.1)
E4K63_RS02050	ENOG4105VGS	50s ribosomal protein l32
E4K63_RS02060	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
E4K63_RS02065	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
E4K63_RS02070	ENOG4105CHR	reductase
E4K63_RS02075	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
E4K63_RS02080	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E4K63_RS02085	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
E4K63_RS02090	ENOG4105CX6	glutaminyL-tRNA synthetase
E4K63_RS02105	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
E4K63_RS02115	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
E4K63_RS02125	ENOG4105DFU	Cell wall formation (By similarity)
E4K63_RS02130	ENOG4105C2N	RNA methyltransferase TrmH family group 3
E4K63_RS02135	ENOG4105K89	arsenate reductase
E4K63_RS02140	ENOG4105E9K	Isocitrate dehydrogenase
E4K63_RS02150	ENOG4105CQ7	ATP-dependent helicase
E4K63_RS02155	ENOG4105C5E	polysaccharide biosynthesis protein
E4K63_RS02170	ENOG4105D3Q	Sugar transferase
E4K63_RS02190	ENOG4105C5E	polysaccharide biosynthesis protein
E4K63_RS02205	ENOG4108TMJ	glycosyl transferase
E4K63_RS02225	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
E4K63_RS02280	ENOG4105XMH	SpoVT AbrB domain protein
E4K63_RS02285	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
E4K63_RS02325	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
E4K63_RS02345	ENOG4105D0M	Protease HtpX homolog
E4K63_RS02370	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
E4K63_RS02380	ENOG4105KHU	inner membrane protein YohD
E4K63_RS02395	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
E4K63_RS02420	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
E4K63_RS02430	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
E4K63_RS02435	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
E4K63_RS02440	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
E4K63_RS02465	ENOG4105YVM	Phosphoesterase, PA-phosphatase related
E4K63_RS02480	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
E4K63_RS02485	ENOG4107MKT	Stringent starvation protein a
E4K63_RS02490	ENOG4105ERU	peptidase
E4K63_RS02495	ENOG4107QRG	dna polymerase iii
E4K63_RS02500	ENOG41090HT	Inherit from COG: transposase
E4K63_RS02505	ENOG4105HBR	Rna-binding protein
E4K63_RS02510	ENOG4105D52	delta-aminolevulinic acid dehydratase
E4K63_RS02515	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
E4K63_RS02525	ENOG4107RUE	extracellular solute-binding protein family 1
E4K63_RS02530	ENOG4105E5D	amino acid
E4K63_RS02545	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
E4K63_RS02555	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
E4K63_RS02565	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
E4K63_RS02570	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
E4K63_RS02585	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
E4K63_RS02600	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
E4K63_RS02610	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
E4K63_RS02615	ENOG4105C3M	thioredoxin reductase
E4K63_RS02630	ENOG4106N3A	copper homeostasis protein cutc
E4K63_RS02645	ENOG4105F4G	Membrane
E4K63_RS02650	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
E4K63_RS02665	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
E4K63_RS02675	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E4K63_RS02690	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
E4K63_RS02695	ENOG4105CEY	Amp-dependent synthetase and ligase
E4K63_RS02700	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
E4K63_RS02710	ENOG4105CJN	penicillin-binding protein
E4K63_RS02715	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
E4K63_RS02735	ENOG4105DBI	uridine monophosphokinase
E4K63_RS02740	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
E4K63_RS02755	ENOG4107XDY	Nicotinamide Mononucleotide Transporter
E4K63_RS02770	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
E4K63_RS02775	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
E4K63_RS02780	ENOG4105C44	Serine transporter
E4K63_RS02790	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
E4K63_RS02835	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
E4K63_RS02840	ENOG4105ECY	inositol monophosphatase
E4K63_RS02845	ENOG4105HMI	Membrane
E4K63_RS02870	ENOG4107QHF	type ii secretion system protein e
E4K63_RS02880	ENOG4105CEV	competence damage-inducible protein
E4K63_RS02910	ENOG4105D01	(LipO)protein
E4K63_RS02940	ENOG4105VIE	preprotein translocase, subunit YajC
E4K63_RS02945	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E4K63_RS02950	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E4K63_RS02960	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E4K63_RS02965	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
E4K63_RS02975	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E4K63_RS02980	ENOG4105HDK	L-asparaginase
E4K63_RS02985	ENOG41077A9	carbonic anhydrase
E4K63_RS03000	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
E4K63_RS03005	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
E4K63_RS03010	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
E4K63_RS03015	ENOG4105K70	DNA-binding protein
E4K63_RS03030	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
E4K63_RS03035	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
E4K63_RS03040	ENOG4107QJR	hflk protein
E4K63_RS03045	ENOG4105EPW	hflc protein
E4K63_RS03050	ENOG4105KJF	protein tyrosine phosphatase
E4K63_RS03065	ENOG4108UYE	Lactoylglutathione lyase
E4K63_RS03080	ENOG4108URH	decarboxylase
E4K63_RS03085	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
E4K63_RS03090	ENOG4105C2X	Arabinose 5-phosphate isomerase
E4K63_RS03095	ENOG4105DJV	ribulose-phosphate 3-epimerase
E4K63_RS03105	ENOG4107UH8	sugar kinase
E4K63_RS03165	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
E4K63_RS03170	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
E4K63_RS03185	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
E4K63_RS03195	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
E4K63_RS03205	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E4K63_RS03210	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
E4K63_RS03215	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
E4K63_RS03220	ENOG4105C0B	DNA polymerase III (alpha subunit)
E4K63_RS03275	ENOG4105E0U	tyrosine-specific transport protein
E4K63_RS03285	ENOG4105CXN	decarboxylase
E4K63_RS03290	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
E4K63_RS03295	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
E4K63_RS03305	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4K63_RS03330	ENOG4108ETY	sodium dicarboxylate symporter
E4K63_RS03340	ENOG4107QNK	)-transporter
E4K63_RS03345	ENOG4107QNR	UPF0135 protein
E4K63_RS03355	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
E4K63_RS03390	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
E4K63_RS03400	ENOG4108X4Q	Hydrolase
E4K63_RS03410	ENOG4105D3W	isochorismatase
E4K63_RS03415	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
E4K63_RS03425	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
E4K63_RS03430	ENOG4105C4R	Atp-dependent dna helicase
E4K63_RS03435	ENOG4107QNK	)-transporter
E4K63_RS03450	ENOG4105C9Q	fumarate hydratase class II
E4K63_RS03455	ENOG4105CHH	sulfate transporter
E4K63_RS03470	ENOG4105C5H	ABC transporter
E4K63_RS03475	ENOG4105C94	Transporter
E4K63_RS03480	ENOG4108RWN	rrna methyltransferase
E4K63_RS03500	ENOG4105W87	Cbs domain
E4K63_RS03515	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
E4K63_RS03525	ENOG4105C2C	drug resistance transporter, Bcr CflA
E4K63_RS03545	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
E4K63_RS03560	ENOG4105EHV	domain protein
E4K63_RS03565	ENOG4105VW4	glutaredoxin 3
E4K63_RS03585	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
E4K63_RS03595	ENOG4105CUZ	uba thif-type nad fad binding protein
E4K63_RS03605	ENOG4105D3R	alkyl hydroperoxide reductase
E4K63_RS03615	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
E4K63_RS03620	ENOG4107RZZ	dna polymerase iii epsilon subunit
E4K63_RS03640	ENOG4105C26	Dehydrogenase
E4K63_RS03655	ENOG4105KTH	gatB Yqey
E4K63_RS03660	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
E4K63_RS03665	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E4K63_RS03675	ENOG4108JU6	CBS domain protein
E4K63_RS03685	ENOG4105C3G	gtp-binding protein
E4K63_RS03690	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
E4K63_RS03710	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
E4K63_RS03720	ENOG4105K6H	D-cysteine desulfhydrase
E4K63_RS03725	ENOG4105VCQ	rubredoxin
E4K63_RS03750	ENOG4105E9S	glutaredoxin 2
E4K63_RS03755	ENOG4108R3D	Electron transport complex
E4K63_RS03760	ENOG4105CSM	endonuclease III
E4K63_RS03775	ENOG4108MN8	Membrane
E4K63_RS03780	ENOG4108JA2	transcriptioN-repair coupling factor
E4K63_RS03795	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
E4K63_RS03815	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
E4K63_RS03830	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
E4K63_RS03845	ENOG4105CQB	FAD linked oxidase domain protein
E4K63_RS03880	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
E4K63_RS03910	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
E4K63_RS03925	ENOG4107KD5	Flavinator of succinate dehydrogenase
E4K63_RS03930	ENOG4105C26	Dehydrogenase
E4K63_RS03935	ENOG4107QTZ	amino acid
E4K63_RS03940	ENOG4107RGD	Major Facilitator superfamily
E4K63_RS03945	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
E4K63_RS03950	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
E4K63_RS03975	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
E4K63_RS03995	ENOG4105CQC	Prephenate dehydratase
E4K63_RS04000	ENOG4108V06	Glutathione peroxidase
E4K63_RS04005	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
E4K63_RS04025	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
E4K63_RS04035	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
E4K63_RS04040	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
E4K63_RS04050	ENOG4105E5D	amino acid
E4K63_RS04055	ENOG4105C1A	potassium transporter peripheral membrane
E4K63_RS04070	ENOG4105C3K	feS assembly ATPase SufC
E4K63_RS04075	ENOG4105JRK	feS assembly protein SufD
E4K63_RS04095	ENOG4105K63	Thioredoxin
E4K63_RS04110	ENOG4105M6F	mutator MutT protein
E4K63_RS04115	ENOG4108UJU	UPF0301 protein
E4K63_RS04120	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
E4K63_RS04135	ENOG4105CUY	Mechanosensitive ion channel
E4K63_RS04145	ENOG4105D1F	ATP-binding protein
E4K63_RS04150	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
E4K63_RS04160	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
E4K63_RS04180	ENOG4105DUX	Transporter
E4K63_RS04190	ENOG4108UHU	Aldolase
E4K63_RS04210	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
E4K63_RS04215	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
E4K63_RS04225	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
E4K63_RS04250	ENOG4105C1J	atp-dependent rna helicase
E4K63_RS04255	ENOG4105EUJ	GTP cyclohydrolase i
E4K63_RS04270	ENOG4105CPC	Aldo Keto reductase
E4K63_RS04280	ENOG4105DDQ	anthranilate synthase
E4K63_RS04290	ENOG4105CEY	Amp-dependent synthetase and ligase
E4K63_RS04315	ENOG4105EEI	dihydropteroate synthase
E4K63_RS04325	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
E4K63_RS04330	ENOG4105D7Z	glutathione synthase
E4K63_RS04335	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
E4K63_RS04370	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
E4K63_RS04410	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4K63_RS04415	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
E4K63_RS04420	ENOG4105CI3	gtp-binding protein typa
E4K63_RS04435	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
E4K63_RS04440	ENOG41090HT	Inherit from COG: transposase
E4K63_RS04445	ENOG4105VDB	UPF0125 protein
E4K63_RS04450	ENOG4108Z1B	Cyclase dehydrase
E4K63_RS04460	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
E4K63_RS04465	ENOG4105CSH	Transporter
E4K63_RS04475	ENOG4105CGK	Exodeoxyribonuclease III
E4K63_RS04485	ENOG4105DC8	reductase
E4K63_RS04515	ENOG4105F0N	pyrophosphate phospho-hydrolase
E4K63_RS04520	ENOG4105DZ1	carboxypeptidase
E4K63_RS04525	ENOG4108Z43	UPF0250 protein
E4K63_RS04545	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
E4K63_RS04555	ENOG41072GX	Peptidase M22 Glycoprotease
E4K63_RS04565	ENOG4105CE4	GlcNAc 6-P deacetylase
E4K63_RS04570	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
E4K63_RS04580	ENOG4105CUZ	uba thif-type nad fad binding protein
E4K63_RS04595	ENOG4107SDT	Homocitrate synthase
E4K63_RS04605	ENOG4107104	thymidine kinase
E4K63_RS04620	ENOG4105C9A	Phoh family
E4K63_RS04630	ENOG4108JU5	Magnesium and cobalt efflux protein
E4K63_RS04635	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
E4K63_RS04640	ENOG4105CGY	Dna recombination protein
E4K63_RS04650	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
E4K63_RS04655	ENOG4105C2C	drug resistance transporter, Bcr CflA
E4K63_RS04660	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
E4K63_RS04665	ENOG4105F8V	Hydrolase, tatD family
E4K63_RS04670	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
E4K63_RS04690	ENOG4105DQR	SNARE associated Golgi
E4K63_RS04695	ENOG4105DQR	SNARE associated Golgi
E4K63_RS04710	ENOG4105C3J	Cysteine desulfurase
E4K63_RS04715	ENOG4105C03	ribonuclease
E4K63_RS04725	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
E4K63_RS04730	ENOG4108JQ1	Dehydrogenase
E4K63_RS04740	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
E4K63_RS04750	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
E4K63_RS04755	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
E4K63_RS04765	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
E4K63_RS04790	ENOG4105C1J	atp-dependent rna helicase
E4K63_RS04795	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
E4K63_RS04815	ENOG4105W49	UPF0434 protein
E4K63_RS04820	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
E4K63_RS04825	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
E4K63_RS04845	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
E4K63_RS04850	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
E4K63_RS04890	ENOG4105FE9	pseudouridine synthase
E4K63_RS04905	ENOG4105CDU	Replicative dna helicase
E4K63_RS04910	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
E4K63_RS04915	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
E4K63_RS04920	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
E4K63_RS04930	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
E4K63_RS04935	ENOG4105CAT	Cytidine monophosphate kinase
E4K63_RS04950	ENOG4105C5Q	Transcriptional regulator
E4K63_RS04970	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
E4K63_RS04985	ENOG4105EAH	synthase
E4K63_RS05005	ENOG4105MZG	transcriptional modulator of maze toxin, mazf
E4K63_RS05035	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
E4K63_RS05040	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
E4K63_RS05065	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
E4K63_RS05070	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
E4K63_RS05075	ENOG4108IUZ	ABC transporter
E4K63_RS05105	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
E4K63_RS05110	ENOG4105CJB	Exodeoxyribonuclease I
E4K63_RS05125	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
E4K63_RS05155	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
E4K63_RS05165	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
E4K63_RS05185	ENOG4105UYK	outer membrane protein a
E4K63_RS05195	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
E4K63_RS05205	ENOG4105VG1	fes assembly suf system protein
E4K63_RS05210	ENOG4108Z4V	iron-sulfur cluster assembly
E4K63_RS05215	ENOG4105C9B	Cysteine desulfurase
E4K63_RS05220	ENOG4105EJQ	L-serine dehydratase
E4K63_RS05230	ENOG4105CGH	5'-nucleotidase
E4K63_RS05235	ENOG4105CQC	Prephenate dehydratase
E4K63_RS05250	ENOG4107QTZ	amino acid
E4K63_RS05285	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
E4K63_RS05290	ENOG4105F38	ABC transporter, permease
E4K63_RS05295	ENOG4105D38	putrescine abc transporter
E4K63_RS05310	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
E4K63_RS05325	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
E4K63_RS05335	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
E4K63_RS05360	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
E4K63_RS05365	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
E4K63_RS05370	ENOG4108M8S	permease YjgP YjgQ family protein
E4K63_RS05375	ENOG4108K5H	permease YjgP YjgQ family protein
E4K63_RS05390	ENOG4106H78	methyltransferase
E4K63_RS05395	ENOG4105EN6	Membrane
E4K63_RS05400	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
E4K63_RS05405	ENOG4108I5U	Uridine phosphorylase
E4K63_RS05410	ENOG4105KG3	cytidine deaminase
E4K63_RS05420	ENOG4105CQB	FAD linked oxidase domain protein
E4K63_RS05425	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E4K63_RS05455	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
E4K63_RS05470	ENOG4105EVU	fructokinase
E4K63_RS05490	ENOG4108JJ9	ABC, transporter
E4K63_RS05495	ENOG4108JJ8	(ABC) transporter
E4K63_RS05530	ENOG4105KME	endoribonuclease L-psp
E4K63_RS05535	ENOG4105CXY	transporter
E4K63_RS05550	ENOG4105WS7	Cation transport regulator
E4K63_RS05555	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
E4K63_RS05565	ENOG4105C7N	Xanthine uracil vitamin C permease
E4K63_RS05570	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
E4K63_RS05575	ENOG4105CSH	Transporter
E4K63_RS05650	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
E4K63_RS05675	ENOG4105CHM	Aminotransferase
E4K63_RS05680	ENOG4105CZ7	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
E4K63_RS05690	ENOG4108ZZ3	UPF0260 protein
E4K63_RS05735	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
E4K63_RS05740	ENOG4108V62	Rhodanese domain protein
E4K63_RS05750	ENOG4107QUY	Guanine deaminase
E4K63_RS05765	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
E4K63_RS05770	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
E4K63_RS05775	ENOG4105QNR	S1 RNA binding domain protein
E4K63_RS05795	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
E4K63_RS05800	ENOG4105E3A	(ABC) transporter
E4K63_RS05805	ENOG4105DA5	(ABC) transporter
E4K63_RS05810	ENOG4105EJ9	Membrane
E4K63_RS05820	ENOG4105F8V	Hydrolase, tatD family
E4K63_RS05825	ENOG4105DSY	exodeoxyribonuclease V, gamma
E4K63_RS05865	ENOG4105C5H	ABC transporter
E4K63_RS05890	ENOG4105CEY	Amp-dependent synthetase and ligase
E4K63_RS05895	ENOG4107QPN	acyl-Coa dehydrogenase
E4K63_RS05905	ENOG4105CHU	acetyl-coa acetyltransferase
E4K63_RS05920	ENOG4105EJ9	Membrane
E4K63_RS05925	ENOG4108SGR	YheO domain-containing protein
E4K63_RS05935	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
E4K63_RS05940	ENOG4105UYK	outer membrane protein a
E4K63_RS05960	ENOG4105M8F	Biopolymer transport protein exbD tolR
E4K63_RS05965	ENOG4105E02	MotA TolQ exbB proton channel
E4K63_RS05975	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
E4K63_RS05980	ENOG4105KHN	chorismate mutase
E4K63_RS06005	ENOG4105C79	DNA protecting protein DprA
E4K63_RS06015	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
E4K63_RS06040	ENOG4105CNI	cell division protein FtsW
E4K63_RS06060	ENOG4105VEQ	Cold shock protein
E4K63_RS06135	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
E4K63_RS06170	ENOG4107QYX	exodeoxyribonuclease v alpha
E4K63_RS06175	ENOG4107QKA	exodeoxyribonuclease V beta
E4K63_RS06180	ENOG4108Z4T	Peptidase M50
E4K63_RS06195	ENOG4105D1H	recombination factor protein RarA
E4K63_RS06205	ENOG4105C9X	ppx gppa phosphatase
E4K63_RS06210	ENOG4105K63	Thioredoxin
E4K63_RS06215	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
E4K63_RS06235	ENOG4105CYW	agmatinase
E4K63_RS06245	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
E4K63_RS06255	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
E4K63_RS06260	ENOG4105C3F	Signal peptidase i
E4K63_RS06265	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
E4K63_RS06270	ENOG4105II7	pyrroline-5-carboxylate reductase
E4K63_RS06275	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
E4K63_RS06280	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
E4K63_RS06290	ENOG4105VE1	Phosphatidylcholine synthase
E4K63_RS06295	ENOG4105CSR	polyphosphate kinase 2
E4K63_RS06325	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
E4K63_RS06340	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4K63_RS06350	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E4K63_RS06370	ENOG4105CZQ	inner membrane transport protein YdhC
E4K63_RS06380	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
E4K63_RS06385	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
E4K63_RS06415	ENOG4107QN2	dihydrolipoyl dehydrogenase
E4K63_RS06420	ENOG4107QSN	dihydrolipoamide acetyltransferase
E4K63_RS06425	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
E4K63_RS06470	ENOG4105E12	capsule polysaccharide
E4K63_RS06490	ENOG4108R66	Conserved Protein
E4K63_RS06505	ENOG4108JQ1	Dehydrogenase
E4K63_RS06510	ENOG4105CNV	Aldolase
E4K63_RS06525	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
E4K63_RS06530	ENOG4107TXM	Nad-dependent epimerase dehydratase
E4K63_RS06535	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
E4K63_RS06565	ENOG4107V1M	polysaccharide export protein
E4K63_RS06580	ENOG4105ECX	polysaccharide export
E4K63_RS06585	ENOG41084CK	capsule polysaccharide
E4K63_RS06590	ENOG4108W6C	Dehydrogenase
E4K63_RS06595	ENOG4107UZV	polysaccharide biosynthesis
E4K63_RS06645	ENOG4107QKV	phosphomannomutase
E4K63_RS06655	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
E4K63_RS06670	ENOG4105C31	Tryptophanyl-tRNA synthetase
E4K63_RS06680	ENOG4105EEQ	Na H antiporter
E4K63_RS06735	ENOG4105E0U	tyrosine-specific transport protein
E4K63_RS06740	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E4K63_RS06760	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
E4K63_RS06775	ENOG4105E0U	tyrosine-specific transport protein
E4K63_RS06790	ENOG4105E5D	amino acid
E4K63_RS06795	ENOG4105D82	Glutamate dehydrogenase
E4K63_RS06800	ENOG4105CBX	hi0933 family
E4K63_RS06810	ENOG4105E1F	short-chain dehydrogenase reductase
E4K63_RS06815	ENOG4105CEP	NADH dehydrogenase
E4K63_RS06825	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
E4K63_RS06830	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
E4K63_RS06875	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
E4K63_RS06905	ENOG4105CK7	Sodium proline symporter
E4K63_RS06910	ENOG4105CBT	Fructose-1,6-bisphosphatase
E4K63_RS06915	ENOG4105DHZ	alpha beta
E4K63_RS06920	ENOG4108IQI	permease
E4K63_RS06930	ENOG4105CNU	cell division protein FtsK
E4K63_RS06950	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
E4K63_RS06980	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
E4K63_RS06990	ENOG4105D9M	gamma-glutamylcysteine synthetase
E4K63_RS06995	ENOG4105CJR	Integral membrane protein (MviN
E4K63_RS07005	ENOG4105K8N	protein family UPF0079, ATPase
E4K63_RS07010	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
E4K63_RS07015	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
E4K63_RS07070	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4K63_RS07080	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
E4K63_RS07100	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
E4K63_RS07110	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
E4K63_RS07115	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
E4K63_RS07135	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
E4K63_RS07145	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
E4K63_RS07155	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
E4K63_RS07160	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
E4K63_RS07165	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4K63_RS07195	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
E4K63_RS07205	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
E4K63_RS07210	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
E4K63_RS07215	ENOG4105KNE	Phosphatidate cytidylyltransferase
E4K63_RS07220	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
E4K63_RS07240	ENOG4105CE9	30S ribosomal protein S2
E4K63_RS07245	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
E4K63_RS07250	ENOG4107RDB	Major Facilitator
E4K63_RS07255	ENOG4105C4M	(Ubiquinol oxidase) subunit I
E4K63_RS07260	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
E4K63_RS07310	ENOG4105C25	Primosomal protein n'
E4K63_RS07320	ENOG4107S2Z	UPF0761 membrane protein
E4K63_RS07325	ENOG4105CS1	NAD(P)H quinone oxidoreductase
E4K63_RS07345	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
E4K63_RS07365	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
E4K63_RS07370	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
E4K63_RS07375	ENOG4105DC1	bifunctional purine biosynthesis protein purh
E4K63_RS07410	ENOG4105C5H	ABC transporter
E4K63_RS07425	ENOG4105C5I	Dehydrogenase
E4K63_RS07430	ENOG4105CSH	Transporter
E4K63_RS07440	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
E4K63_RS07445	ENOG4107YZP	Rhodanese domain protein
E4K63_RS07455	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
E4K63_RS07465	ENOG4108UUM	single-stranded DNA-binding protein
E4K63_RS07505	ENOG4108DNC	Involved in acetate metabolism (By similarity)
E4K63_RS07510	ENOG4105C26	Dehydrogenase
E4K63_RS07530	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
E4K63_RS07590	ENOG4105DK0	Indole-3-glycerol phosphate synthase
E4K63_RS07595	ENOG4105CD3	dihydroorotase
E4K63_RS07605	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
E4K63_RS07685	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
E4K63_RS07715	ENOG4107QVM	von Willebrand factor, type A
E4K63_RS07735	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
E4K63_RS07750	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
E4K63_RS07775	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
E4K63_RS07780	ENOG4105CCU	oxidase (Subunit III)
E4K63_RS07785	ENOG4105BZ9	Cytochrome C oxidase, subunit I
E4K63_RS07800	ENOG4105NTZ	Preprotein translocase subunit SecG
E4K63_RS07820	ENOG4105C7S	Dehydrogenase
E4K63_RS07825	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
E4K63_RS07830	ENOG4105E33	succinate dehydrogenase
E4K63_RS07835	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
E4K63_RS07840	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
E4K63_RS07845	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
E4K63_RS07850	ENOG4105BZN	citrate synthase
E4K63_RS07855	ENOG4105EYM	Major Facilitator superfamily
E4K63_RS07860	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
E4K63_RS07865	ENOG4105M2J	Glutaredoxin
E4K63_RS07880	ENOG4105CRK	lysyL-tRNA synthetase
E4K63_RS07940	ENOG41081QV	Universal stress protein
E4K63_RS07960	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
E4K63_RS07975	ENOG4108R6K	riboflavin synthase, subunit alpha
E4K63_RS07980	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
E4K63_RS07985	ENOG4105NZG	Ferredoxin
E4K63_RS08020	ENOG4108Z4U	Ferredoxin
E4K63_RS08035	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
E4K63_RS08040	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
E4K63_RS08075	ENOG4105DDQ	anthranilate synthase
E4K63_RS08080	ENOG4105CRQ	synthase (Component I)
E4K63_RS08100	ENOG4105C03	ribonuclease