locus-tag	class	description
E4K63_RS00010	COG0592	DNA-directed DNA polymerase activity
E4K63_RS00030	COG0540	Belongs to the ATCase OTCase family
E4K63_RS00035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4K63_RS00040	COG0505	Belongs to the CarA family
E4K63_RS00050	COG0557	exoribonuclease II activity
E4K63_RS00090	COG1116	anion transmembrane transporter activity
E4K63_RS00105	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4K63_RS00130	COG0762	integral membrane protein
E4K63_RS00135	COG1872	DUF167
E4K63_RS00145	COG0189	ligase activity
E4K63_RS00195	COG2333	competence protein COMEC
E4K63_RS00195	COG0658	competence protein
E4K63_RS00230	COG0531	amino acid
E4K63_RS00285	COG3328	transposase activity
E4K63_RS00300	COG0814	amino acid
E4K63_RS00305	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4K63_RS00310	COG0531	amino acid
E4K63_RS00315	COG4178	(ABC) transporter
E4K63_RS00320	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4K63_RS00330	COG0574	Belongs to the PEP-utilizing enzyme family
E4K63_RS00330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4K63_RS00335	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4K63_RS00355	COG1560	Kdo2-lipid A biosynthetic process
E4K63_RS00360	COG1560	Kdo2-lipid A biosynthetic process
E4K63_RS00365	COG0706	membrane insertase activity
E4K63_RS00375	COG0594	ribonuclease P activity
E4K63_RS00385	COG0814	amino acid
E4K63_RS00390	COG0357	Ribosomal RNA small subunit methyltransferase G
E4K63_RS00395	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4K63_RS00400	COG0583	DNA-binding transcription factor activity
E4K63_RS00405	COG2814	Major facilitator Superfamily
E4K63_RS00410	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4K63_RS00445	COG0542	response to heat
E4K63_RS00475	COG0204	Acyl-transferase
E4K63_RS00485	COG0009	L-threonylcarbamoyladenylate synthase
E4K63_RS00525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4K63_RS00550	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4K63_RS00555	COG2814	Major facilitator Superfamily
E4K63_RS00575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4K63_RS00580	COG1538	Outer membrane efflux protein
E4K63_RS00590	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4K63_RS00595	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4K63_RS00595	COG0047	phosphoribosylformylglycinamidine synthase activity
E4K63_RS00600	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4K63_RS00615	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4K63_RS00620	COG0154	amidase activity
E4K63_RS00645	COG2814	Major facilitator Superfamily
E4K63_RS00670	COG0076	glutamate decarboxylase activity
E4K63_RS00680	COG0527	aspartate kinase activity
E4K63_RS00710	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4K63_RS00720	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4K63_RS00730	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E4K63_RS00740	COG1034	ATP synthesis coupled electron transport
E4K63_RS00750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4K63_RS00755	COG0839	Belongs to the complex I subunit 6 family
E4K63_RS00760	COG0713	ATP synthesis coupled electron transport
E4K63_RS00790	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4K63_RS00805	COG2251	uridine kinase activity
E4K63_RS00805	COG0195	Participates in both transcription termination and antitermination
E4K63_RS00830	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4K63_RS00835	COG0564	pseudouridine synthase activity
E4K63_RS00885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4K63_RS00940	COG0814	amino acid
E4K63_RS00945	COG3040	lipid binding
E4K63_RS00955	COG2066	Belongs to the glutaminase family
E4K63_RS00970	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4K63_RS00975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4K63_RS00980	COG1127	ABC transporter
E4K63_RS00985	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E4K63_RS00995	COG0850	regulation of cytokinetic process
E4K63_RS01015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4K63_RS01040	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4K63_RS01045	COG1051	belongs to the nudix hydrolase family
E4K63_RS01055	COG2252	PERMEase
E4K63_RS01060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4K63_RS01095	COG1294	oxidase, subunit
E4K63_RS01100	COG1271	oxidase subunit
E4K63_RS01105	COG0642	Histidine kinase
E4K63_RS01135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4K63_RS01140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4K63_RS01145	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4K63_RS01165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4K63_RS01165	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4K63_RS01175	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E4K63_RS01180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4K63_RS01185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4K63_RS01205	COG0552	protein localization to endoplasmic reticulum
E4K63_RS01215	COG0210	DNA helicase
E4K63_RS01220	COG2271	Major facilitator Superfamily
E4K63_RS01235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4K63_RS01245	COG0668	transmembrane transport
E4K63_RS01265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4K63_RS01275	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4K63_RS01285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4K63_RS01290	COG0081	regulation of translation
E4K63_RS01320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4K63_RS01330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4K63_RS01345	COG0336	Belongs to the RNA methyltransferase TrmD family
E4K63_RS01355	COG4974	Belongs to the 'phage' integrase family
E4K63_RS01375	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4K63_RS01390	COG2814	Major facilitator Superfamily
E4K63_RS01395	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4K63_RS01415	COG2890	protein-(glutamine-N5) methyltransferase activity
E4K63_RS01430	COG0792	nuclease activity
E4K63_RS01435	COG0339	signal peptide processing
E4K63_RS01465	COG3328	transposase activity
E4K63_RS01480	COG0529	Catalyzes the synthesis of activated sulfate
E4K63_RS01495	COG0175	sulfate reduction
E4K63_RS01515	COG1132	(ABC) transporter
E4K63_RS01530	COG0367	asparagine synthase
E4K63_RS01565	COG1192	Involved in chromosome partitioning
E4K63_RS01570	COG1475	DNA binding
E4K63_RS01575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4K63_RS01575	COG0519	Catalyzes the synthesis of GMP from XMP
E4K63_RS01615	COG0196	riboflavin kinase activity
E4K63_RS01620	COG0281	malic enzyme
E4K63_RS01635	COG1160	GTP binding
E4K63_RS01640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4K63_RS01645	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4K63_RS01660	COG1040	competence protein
E4K63_RS01665	COG0537	adenosine 5'-monophosphoramidase activity
E4K63_RS01670	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4K63_RS01680	COG2226	methyltransferase
E4K63_RS01690	COG0837	glucose binding
E4K63_RS01705	COG0009	L-threonylcarbamoyladenylate synthase
E4K63_RS01710	COG2271	Major facilitator Superfamily
E4K63_RS01785	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4K63_RS01815	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4K63_RS01830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4K63_RS01840	COG0625	glutathione transferase activity
E4K63_RS01845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E4K63_RS01850	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4K63_RS01865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4K63_RS01870	COG0443	Heat shock 70 kDa protein
E4K63_RS01925	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4K63_RS01955	COG0477	Major facilitator Superfamily
E4K63_RS01960	COG0318	PFAM AMP-dependent synthetase and ligase
E4K63_RS01970	COG3104	oligopeptide transport
E4K63_RS01975	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4K63_RS01995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4K63_RS02000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4K63_RS02005	COG2992	FlgJ-related protein
E4K63_RS02015	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4K63_RS02020	COG0191	fructose-bisphosphate aldolase activity
E4K63_RS02030	COG0126	phosphoglycerate kinase activity
E4K63_RS02050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4K63_RS02060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4K63_RS02065	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4K63_RS02070	COG1028	Short-chain dehydrogenase reductase Sdr
E4K63_RS02075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4K63_RS02080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4K63_RS02085	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E4K63_RS02090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4K63_RS02105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4K63_RS02125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4K63_RS02130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4K63_RS02135	COG1393	Belongs to the ArsC family
E4K63_RS02150	COG1643	Atp-dependent helicase
E4K63_RS02155	COG1086	Polysaccharide biosynthesis protein
E4K63_RS02170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4K63_RS02190	COG1086	Polysaccharide biosynthesis protein
E4K63_RS02205	COG0438	transferase activity, transferring glycosyl groups
E4K63_RS02225	COG1088	dTDP-glucose 4,6-dehydratase activity
E4K63_RS02280	COG4456	Virulence-associated protein
E4K63_RS02285	COG1487	ribonuclease activity
E4K63_RS02325	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4K63_RS02345	COG0501	Belongs to the peptidase M48B family
E4K63_RS02380	COG0586	Pfam SNARE associated Golgi protein
E4K63_RS02395	COG0662	Cupin 2, conserved barrel domain protein
E4K63_RS02395	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E4K63_RS02420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4K63_RS02430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4K63_RS02465	COG0671	phosphoesterase, PA-phosphatase related
E4K63_RS02480	COG2920	part of a sulfur-relay system
E4K63_RS02485	COG0625	glutathione transferase activity
E4K63_RS02490	COG0616	signal peptide processing
E4K63_RS02495	COG0470	DNA polymerase III
E4K63_RS02500	COG1943	Transposase
E4K63_RS02505	COG1534	Rna-binding protein
E4K63_RS02510	COG0113	porphobilinogen synthase activity
E4K63_RS02515	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4K63_RS02525	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4K63_RS02530	COG0531	amino acid
E4K63_RS02545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4K63_RS02555	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4K63_RS02565	COG0439	Biotin carboxylase
E4K63_RS02585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4K63_RS02600	COG1162	GTPase activity
E4K63_RS02610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4K63_RS02615	COG0492	ferredoxin-NADP+ reductase activity
E4K63_RS02645	COG0628	permease
E4K63_RS02665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4K63_RS02675	COG0187	DNA topoisomerase II activity
E4K63_RS02690	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4K63_RS02695	COG0318	PFAM AMP-dependent synthetase and ligase
E4K63_RS02695	COG0204	Acyl-transferase
E4K63_RS02700	COG0275	rRNA processing
E4K63_RS02705	COG3116	cell division
E4K63_RS02715	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4K63_RS02735	COG0572	uridine kinase
E4K63_RS02740	COG1758	RNA polymerase activity
E4K63_RS02770	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4K63_RS02775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4K63_RS02780	COG0814	amino acid
E4K63_RS02790	COG0156	8-amino-7-oxononanoate synthase activity
E4K63_RS02835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4K63_RS02835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4K63_RS02840	COG0483	inositol monophosphate 1-phosphatase activity
E4K63_RS02845	COG2855	membrane
E4K63_RS02870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4K63_RS02880	COG1058	Belongs to the CinA family
E4K63_RS02880	COG1546	Belongs to the CinA family
E4K63_RS02885	COG0189	ligase activity
E4K63_RS02885	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4K63_RS02890	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4K63_RS02890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4K63_RS02910	COG1464	Belongs to the NlpA lipoprotein family
E4K63_RS02940	COG1862	Preprotein translocase
E4K63_RS02945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4K63_RS02950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4K63_RS02960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4K63_RS02965	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4K63_RS02975	COG0328	RNA-DNA hybrid ribonuclease activity
E4K63_RS02980	COG0252	asparaginase activity
E4K63_RS02985	COG0288	reversible hydration of carbon dioxide
E4K63_RS03000	COG0740	serine-type endopeptidase activity
E4K63_RS03005	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4K63_RS03010	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4K63_RS03030	COG1923	regulation of RNA biosynthetic process
E4K63_RS03035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4K63_RS03040	COG0330	HflC and HflK could
E4K63_RS03045	COG0330	HflC and HflK could
E4K63_RS03050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4K63_RS03060	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4K63_RS03065	COG0346	lactoylglutathione lyase activity
E4K63_RS03080	COG1611	Belongs to the LOG family
E4K63_RS03090	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4K63_RS03090	COG0517	IMP dehydrogenase activity
E4K63_RS03095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4K63_RS03105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4K63_RS03115	COG1446	asparaginase
E4K63_RS03165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4K63_RS03170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4K63_RS03185	COG0509	glycine decarboxylation via glycine cleavage system
E4K63_RS03195	COG0024	Methionine aminopeptidase
E4K63_RS03205	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4K63_RS03210	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4K63_RS03215	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4K63_RS03220	COG0587	DNA-directed DNA polymerase activity
E4K63_RS03250	COG3328	transposase activity
E4K63_RS03275	COG0814	amino acid
E4K63_RS03285	COG1982	Orn Lys Arg decarboxylase major
E4K63_RS03290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4K63_RS03305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4K63_RS03325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4K63_RS03340	COG2814	Major facilitator Superfamily
E4K63_RS03380	COG3079	Belongs to the UPF0149 family
E4K63_RS03385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4K63_RS03390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4K63_RS03400	COG0561	phosphatase activity
E4K63_RS03410	COG1335	isochorismatase
E4K63_RS03425	COG0354	folic acid binding
E4K63_RS03430	COG0210	DNA helicase
E4K63_RS03435	COG2814	Major facilitator Superfamily
E4K63_RS03455	COG0659	secondary active sulfate transmembrane transporter activity
E4K63_RS03470	COG0488	(ABC) transporter
E4K63_RS03475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4K63_RS03480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4K63_RS03500	COG0517	IMP dehydrogenase activity
E4K63_RS03515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4K63_RS03525	COG2814	Major facilitator Superfamily
E4K63_RS03545	COG0799	negative regulation of ribosome biogenesis
E4K63_RS03560	COG0678	peroxiredoxin activity
E4K63_RS03560	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4K63_RS03565	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4K63_RS03585	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E4K63_RS03595	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4K63_RS03605	COG0450	alkyl hydroperoxide reductase
E4K63_RS03615	COG2824	Alkylphosphonate utilization operon protein PhnA
E4K63_RS03620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4K63_RS03640	COG1012	belongs to the aldehyde dehydrogenase family
E4K63_RS03655	COG1610	YqeY-like protein
E4K63_RS03660	COG0358	DNA primase activity
E4K63_RS03675	COG4536	flavin adenine dinucleotide binding
E4K63_RS03685	COG0012	GTP binding
E4K63_RS03690	COG0193	aminoacyl-tRNA hydrolase activity
E4K63_RS03705	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E4K63_RS03710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4K63_RS03720	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E4K63_RS03725	COG1773	rubredoxin
E4K63_RS03750	COG2999	glutathione oxidoreductase activity
E4K63_RS03755	COG2878	Part of a membrane complex involved in electron transport
E4K63_RS03760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4K63_RS03780	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4K63_RS03795	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4K63_RS03815	COG0632	four-way junction helicase activity
E4K63_RS03830	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4K63_RS03845	COG0277	FAD linked oxidase domain protein
E4K63_RS03880	COG0563	adenylate kinase activity
E4K63_RS03910	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4K63_RS03925	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E4K63_RS03935	COG0531	amino acid
E4K63_RS03940	COG2814	Major facilitator Superfamily
E4K63_RS03945	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4K63_RS03950	COG0415	Belongs to the DNA photolyase family
E4K63_RS03995	COG0077	Prephenate dehydratase
E4K63_RS03995	COG1605	Chorismate mutase
E4K63_RS04000	COG0386	Belongs to the glutathione peroxidase family
E4K63_RS04005	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4K63_RS04005	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4K63_RS04025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4K63_RS04040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4K63_RS04050	COG0531	amino acid
E4K63_RS04055	COG0569	domain protein
E4K63_RS04060	COG1959	2 iron, 2 sulfur cluster binding
E4K63_RS04065	COG0719	Fe-S assembly protein
E4K63_RS04070	COG0396	ATPase activity
E4K63_RS04075	COG0719	Fe-S assembly protein
E4K63_RS04110	COG0494	nUDIX hydrolase
E4K63_RS04115	COG1678	Uncharacterized ACR, COG1678
E4K63_RS04120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4K63_RS04135	COG0668	transmembrane transport
E4K63_RS04160	COG0072	phenylalanine-tRNA ligase activity
E4K63_RS04160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4K63_RS04180	COG3104	oligopeptide transport
E4K63_RS04210	COG2255	four-way junction helicase activity
E4K63_RS04215	COG1028	Short-chain dehydrogenase reductase Sdr
E4K63_RS04225	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4K63_RS04245	COG3328	transposase activity
E4K63_RS04250	COG0513	Belongs to the DEAD box helicase family
E4K63_RS04255	COG0302	gtp cyclohydrolase
E4K63_RS04270	COG0667	Aldo Keto reductase
E4K63_RS04280	COG0512	Glutamine amidotransferase of anthranilate synthase
E4K63_RS04290	COG0318	PFAM AMP-dependent synthetase and ligase
E4K63_RS04315	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4K63_RS04315	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4K63_RS04325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4K63_RS04330	COG0189	ligase activity
E4K63_RS04335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4K63_RS04370	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4K63_RS04400	COG0730	response to heat
E4K63_RS04410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4K63_RS04415	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4K63_RS04440	COG1943	Transposase
E4K63_RS04445	COG2914	Belongs to the UPF0125 (RnfH) family
E4K63_RS04450	COG2867	negative regulation of translational initiation
E4K63_RS04460	COG0037	tRNA processing
E4K63_RS04465	COG0477	Major facilitator Superfamily
E4K63_RS04475	COG0708	Exodeoxyribonuclease III
E4K63_RS04485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4K63_RS04510	COG1570	exodeoxyribonuclease VII activity
E4K63_RS04515	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4K63_RS04520	COG1686	Belongs to the peptidase S11 family
E4K63_RS04525	COG2921	Belongs to the UPF0250 family
E4K63_RS04545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4K63_RS04555	COG1214	PFAM Peptidase M22, glycoprotease
E4K63_RS04570	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E4K63_RS04580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4K63_RS04595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4K63_RS04605	COG1435	thymidine kinase activity
E4K63_RS04620	COG1702	phosphate starvation-inducible protein PhoH
E4K63_RS04635	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4K63_RS04640	COG1322	Protein conserved in bacteria
E4K63_RS04650	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4K63_RS04655	COG2814	Major facilitator Superfamily
E4K63_RS04660	COG0751	glycine-tRNA ligase activity
E4K63_RS04665	COG0084	hydrolase, TatD family'
E4K63_RS04670	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4K63_RS04690	COG0586	Pfam SNARE associated Golgi protein
E4K63_RS04695	COG0586	Pfam SNARE associated Golgi protein
E4K63_RS04715	COG1530	ribonuclease E activity
E4K63_RS04725	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4K63_RS04730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4K63_RS04740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4K63_RS04750	COG0156	8-amino-7-oxononanoate synthase activity
E4K63_RS04790	COG0513	Belongs to the DEAD box helicase family
E4K63_RS04795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4K63_RS04815	COG2835	tetraacyldisaccharide 4'-kinase activity
E4K63_RS04820	COG0425	Belongs to the sulfur carrier protein TusA family
E4K63_RS04825	COG0482	sulfurtransferase activity
E4K63_RS04845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4K63_RS04850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4K63_RS04855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4K63_RS04870	COG0436	Aminotransferase
E4K63_RS04890	COG1187	pseudouridine synthase activity
E4K63_RS04910	COG0359	binds to the 23S rRNA
E4K63_RS04915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4K63_RS04920	COG0360	Binds together with S18 to 16S ribosomal RNA
E4K63_RS04930	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4K63_RS04935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E4K63_RS04950	COG0583	DNA-binding transcription factor activity
E4K63_RS04970	COG0037	tRNA processing
E4K63_RS04985	COG0142	geranyltranstransferase activity
E4K63_RS05005	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4K63_RS05035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4K63_RS05040	COG0095	Lipoate-protein ligase
E4K63_RS05065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E4K63_RS05070	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4K63_RS05075	COG1137	ATPase activity
E4K63_RS05105	COG0556	nucleotide-excision repair
E4K63_RS05110	COG2925	Exonuclease
E4K63_RS05125	COG0445	tRNA wobble uridine modification
E4K63_RS05155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4K63_RS05195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4K63_RS05205	COG2151	metal-sulfur cluster biosynthetic enzyme
E4K63_RS05210	COG0316	Belongs to the HesB IscA family
E4K63_RS05215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4K63_RS05220	COG1760	l-serine dehydratase
E4K63_RS05230	COG0737	Belongs to the 5'-nucleotidase family
E4K63_RS05235	COG1605	Chorismate mutase
E4K63_RS05235	COG0077	Prephenate dehydratase
E4K63_RS05250	COG0531	amino acid
E4K63_RS05285	COG3842	ATPase activity
E4K63_RS05290	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4K63_RS05295	COG1177	transmembrane transport
E4K63_RS05310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4K63_RS05360	COG0516	GMP reductase activity
E4K63_RS05360	COG0517	IMP dehydrogenase activity
E4K63_RS05365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4K63_RS05370	COG0795	lipopolysaccharide-transporting ATPase activity
E4K63_RS05375	COG0795	lipopolysaccharide-transporting ATPase activity
E4K63_RS05380	COG0612	Peptidase, M16
E4K63_RS05390	COG0742	ribosomal rna small subunit methyltransferase
E4K63_RS05395	COG2860	membrane
E4K63_RS05405	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
E4K63_RS05410	COG0295	cytidine deaminase activity
E4K63_RS05420	COG0247	lactate metabolic process
E4K63_RS05420	COG0277	FAD linked oxidase domain protein
E4K63_RS05425	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4K63_RS05455	COG0497	DNA recombination
E4K63_RS05465	COG0436	Aminotransferase
E4K63_RS05470	COG1940	carbohydrate kinase activity
E4K63_RS05490	COG4988	ABC transporter
E4K63_RS05495	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4K63_RS05525	COG1301	dicarboxylic acid transport
E4K63_RS05530	COG0251	oxidation-reduction process
E4K63_RS05535	COG2271	Major facilitator Superfamily
E4K63_RS05550	COG4572	Cation transport regulator
E4K63_RS05555	COG1028	Short-chain dehydrogenase reductase Sdr
E4K63_RS05565	COG2252	PERMEase
E4K63_RS05570	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E4K63_RS05575	COG0477	Major facilitator Superfamily
E4K63_RS05650	COG2166	iron-sulfur cluster assembly
E4K63_RS05675	COG0436	Aminotransferase
E4K63_RS05680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4K63_RS05690	COG2983	Belongs to the UPF0260 family
E4K63_RS05705	COG3328	transposase activity
E4K63_RS05735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4K63_RS05740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4K63_RS05750	COG0402	S-adenosylhomocysteine deaminase activity
E4K63_RS05765	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4K63_RS05770	COG1280	lysine exporter protein (LysE YggA)
E4K63_RS05775	COG2996	Protein conserved in bacteria
E4K63_RS05790	COG0463	Glycosyl transferase, family 2
E4K63_RS05795	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4K63_RS05800	COG0842	Transport permease protein
E4K63_RS05805	COG1131	(ABC) transporter
E4K63_RS05810	COG0730	response to heat
E4K63_RS05820	COG0084	hydrolase, TatD family'
E4K63_RS05825	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4K63_RS05865	COG0488	(ABC) transporter
E4K63_RS05890	COG0318	PFAM AMP-dependent synthetase and ligase
E4K63_RS05895	COG1960	acyl-CoA dehydrogenase activity
E4K63_RS05900	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4K63_RS05900	COG1024	Enoyl-CoA hydratase
E4K63_RS05905	COG0183	Belongs to the thiolase family
E4K63_RS05920	COG0730	response to heat
E4K63_RS05935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4K63_RS05965	COG0811	peptide transport
E4K63_RS05975	COG1183	phosphatidylcholine synthase activity
E4K63_RS05980	COG4401	Chorismate mutase type I
E4K63_RS06005	COG0758	DNA mediated transformation
E4K63_RS06015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4K63_RS06040	COG0772	Belongs to the SEDS family
E4K63_RS06060	COG1278	Cold shock
E4K63_RS06135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4K63_RS06145	COG1051	belongs to the nudix hydrolase family
E4K63_RS06145	COG1056	cytidyltransferase-related domain
E4K63_RS06170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4K63_RS06175	COG1074	ATP-dependent DNA helicase activity
E4K63_RS06180	COG1994	Peptidase M50
E4K63_RS06195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4K63_RS06205	COG0248	Ppx GppA phosphatase
E4K63_RS06235	COG0010	Belongs to the arginase family
E4K63_RS06245	COG0557	exoribonuclease II activity
E4K63_RS06255	COG0571	ribonuclease III activity
E4K63_RS06260	COG0681	Belongs to the peptidase S26 family
E4K63_RS06265	COG0745	RESPONSE REGULATOR receiver
E4K63_RS06270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4K63_RS06275	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4K63_RS06280	COG1519	Transferase
E4K63_RS06290	COG1183	phosphatidylcholine synthase activity
E4K63_RS06325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4K63_RS06340	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4K63_RS06370	COG2814	Major facilitator Superfamily
E4K63_RS06380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4K63_RS06385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4K63_RS06385	COG0473	3-isopropylmalate dehydrogenase activity
E4K63_RS06405	COG3328	transposase activity
E4K63_RS06415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4K63_RS06420	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4K63_RS06490	COG2731	YhcH YjgK YiaL family protein
E4K63_RS06505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4K63_RS06510	COG3836	Belongs to the HpcH HpaI aldolase family
E4K63_RS06525	COG0662	Cupin 2, conserved barrel domain protein
E4K63_RS06525	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E4K63_RS06530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4K63_RS06535	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4K63_RS06590	COG0300	oxidoreductase activity
E4K63_RS06595	COG1368	sulfuric ester hydrolase activity
E4K63_RS06605	COG2124	cytochrome p450
E4K63_RS06640	COG3321	synthase
E4K63_RS06640	COG0604	alcohol dehydrogenase
E4K63_RS06640	COG1028	Short-chain dehydrogenase reductase Sdr
E4K63_RS06645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4K63_RS06655	COG0237	dephospho-CoA kinase activity
E4K63_RS06735	COG0814	amino acid
E4K63_RS06740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E4K63_RS06760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4K63_RS06775	COG0814	amino acid
E4K63_RS06790	COG0531	amino acid
E4K63_RS06795	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4K63_RS06800	COG2081	HI0933 family
E4K63_RS06810	COG0300	oxidoreductase activity
E4K63_RS06815	COG1252	NADH dehydrogenase
E4K63_RS06825	COG0459	protein refolding
E4K63_RS06830	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4K63_RS06875	COG2890	protein-(glutamine-N5) methyltransferase activity
E4K63_RS06905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4K63_RS06910	COG1494	fructose-1,6-bisphosphatase
E4K63_RS06915	COG2945	thiolester hydrolase activity
E4K63_RS06920	COG0833	amino acid
E4K63_RS06930	COG1674	ftsk spoiiie
E4K63_RS06950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4K63_RS06980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4K63_RS06990	COG2918	glutathione biosynthetic process
E4K63_RS07005	COG0802	atpase or kinase
E4K63_RS07010	COG0285	dihydrofolate synthase activity
E4K63_RS07015	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4K63_RS07070	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4K63_RS07080	COG0201	protein transport
E4K63_RS07100	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4K63_RS07110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4K63_RS07115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4K63_RS07135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4K63_RS07145	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4K63_RS07155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4K63_RS07160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4K63_RS07165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4K63_RS07195	COG0049	tRNA binding
E4K63_RS07205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4K63_RS07210	COG0756	dUTP diphosphatase activity
E4K63_RS07215	COG4589	Belongs to the CDS family
E4K63_RS07220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4K63_RS07240	COG0052	Belongs to the universal ribosomal protein uS2 family
E4K63_RS07245	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4K63_RS07250	COG2814	Major facilitator Superfamily
E4K63_RS07260	COG1294	oxidase, subunit
E4K63_RS07310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4K63_RS07320	COG1295	ribonuclease BN
E4K63_RS07345	COG3842	ATPase activity
E4K63_RS07350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4K63_RS07370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E4K63_RS07375	COG0138	bifunctional purine biosynthesis protein purh
E4K63_RS07410	COG0488	(ABC) transporter
E4K63_RS07415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4K63_RS07425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4K63_RS07430	COG0477	Major facilitator Superfamily
E4K63_RS07435	COG2161	toxin-antitoxin pair type II binding
E4K63_RS07440	COG4115	mRNA cleavage
E4K63_RS07445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4K63_RS07455	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4K63_RS07465	COG0629	single-stranded DNA binding
E4K63_RS07505	COG0857	belongs to the CobB CobQ family
E4K63_RS07505	COG0280	phosphate acetyltransferase
E4K63_RS07510	COG1012	belongs to the aldehyde dehydrogenase family
E4K63_RS07530	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4K63_RS07590	COG0134	indole-3-glycerol-phosphate synthase activity
E4K63_RS07590	COG0135	phosphoribosylanthranilate isomerase activity
E4K63_RS07595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4K63_RS07605	COG0167	dihydroorotate dehydrogenase activity
E4K63_RS07685	COG0525	valine-tRNA ligase activity
E4K63_RS07715	COG2304	oxidoreductase activity
E4K63_RS07735	COG0714	Associated with various cellular activities
E4K63_RS07750	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4K63_RS07775	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4K63_RS07785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4K63_RS07800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4K63_RS07830	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4K63_RS07835	COG1053	succinate dehydrogenase
E4K63_RS07840	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4K63_RS07845	COG2009	succinate dehydrogenase
E4K63_RS07855	COG2223	nitrite transmembrane transporter activity
E4K63_RS07865	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4K63_RS07880	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4K63_RS07940	COG0589	response to stress
E4K63_RS07960	COG0242	peptide deformylase activity
E4K63_RS07975	COG0307	riboflavin synthase, alpha
E4K63_RS07980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4K63_RS07980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4K63_RS07985	COG3411	Ferredoxin
E4K63_RS08020	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4K63_RS08035	COG1490	D-aminoacyl-tRNA deacylase activity
E4K63_RS08040	COG1605	Chorismate mutase
E4K63_RS08040	COG0287	Prephenate dehydrogenase
E4K63_RS08075	COG0512	Glutamine amidotransferase of anthranilate synthase
E4K63_RS08080	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4K63_RS08100	COG1530	ribonuclease E activity