locus-tag	class	description
HME7025_RS00015	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HME7025_RS00065	COG1216	Glycosyl transferase, family 2
HME7025_RS00065	COG0463	Glycosyl transferase, family 2
HME7025_RS00095	COG1733	regulation of RNA biosynthetic process
HME7025_RS00135	COG0700	Nucleoside recognition
HME7025_RS00150	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HME7025_RS00155	COG1022	Amp-dependent synthetase and ligase
HME7025_RS00175	COG0445	tRNA wobble uridine modification
HME7025_RS00180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HME7025_RS00185	COG0792	nuclease activity
HME7025_RS00190	COG0321	lipoyl(octanoyl) transferase activity
HME7025_RS00210	COG0038	chloride channel
HME7025_RS00215	COG0513	Belongs to the DEAD box helicase family
HME7025_RS00230	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HME7025_RS00235	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HME7025_RS00250	COG1381	Involved in DNA repair and RecF pathway recombination
HME7025_RS00265	COG0113	porphobilinogen synthase activity
HME7025_RS00270	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HME7025_RS00275	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HME7025_RS00280	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HME7025_RS00295	COG0149	triose-phosphate isomerase activity
HME7025_RS00300	COG1472	Belongs to the glycosyl hydrolase 3 family
HME7025_RS00305	COG1090	epimerase
HME7025_RS00310	COG1611	Belongs to the LOG family
HME7025_RS00315	COG2885	chlorophyll binding
HME7025_RS00330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HME7025_RS00335	COG3620	sequence-specific DNA binding
HME7025_RS00490	COG1876	peptidase activity
HME7025_RS00560	COG1522	sequence-specific DNA binding
HME7025_RS00565	COG0343	queuine tRNA-ribosyltransferase activity
HME7025_RS00600	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HME7025_RS00605	COG4989	oxidoreductase activity
HME7025_RS00610	COG0557	exoribonuclease II activity
HME7025_RS00620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HME7025_RS00625	COG2045	Belongs to the ComB family
HME7025_RS00650	COG0463	Glycosyl transferase, family 2
HME7025_RS00655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HME7025_RS00705	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HME7025_RS00710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HME7025_RS00800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HME7025_RS00805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HME7025_RS00825	COG4771	TonB-dependent receptor
HME7025_RS00900	COG3394	polysaccharide catabolic process
HME7025_RS00910	COG0667	Aldo Keto reductase
HME7025_RS00915	COG0154	amidase activity
HME7025_RS00920	COG5285	phytanoyl-CoA dioxygenase
HME7025_RS00925	COG0673	inositol 2-dehydrogenase activity
HME7025_RS00930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HME7025_RS00960	COG3119	arylsulfatase activity
HME7025_RS00965	COG3408	Glycogen debranching enzyme
HME7025_RS00965	COG3119	arylsulfatase activity
HME7025_RS00985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HME7025_RS01040	COG4771	TonB-dependent receptor
HME7025_RS01065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HME7025_RS01070	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HME7025_RS01075	COG0556	nucleotide-excision repair
HME7025_RS01090	COG3956	TIGRFAM MazG family protein
HME7025_RS01105	COG0673	inositol 2-dehydrogenase activity
HME7025_RS01135	COG0405	Gamma-glutamyltransferase
HME7025_RS01140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HME7025_RS01145	COG0436	Aminotransferase
HME7025_RS01165	COG0140	phosphoribosyl-ATP diphosphatase activity
HME7025_RS01165	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HME7025_RS01170	COG0107	imidazoleglycerol-phosphate synthase activity
HME7025_RS01175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HME7025_RS01190	COG0513	Belongs to the DEAD box helicase family
HME7025_RS01210	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HME7025_RS01225	COG0148	phosphopyruvate hydratase activity
HME7025_RS01235	COG0667	Aldo Keto reductase
HME7025_RS01275	COG1215	transferase activity, transferring glycosyl groups
HME7025_RS01280	COG0357	Ribosomal RNA small subunit methyltransferase G
HME7025_RS01290	COG0306	phosphate transporter
HME7025_RS01300	COG1530	ribonuclease E activity
HME7025_RS01320	COG0629	single-stranded DNA binding
HME7025_RS01325	COG4535	Mg2 and Co2 transporter CorC
HME7025_RS01390	COG1785	Belongs to the alkaline phosphatase family
HME7025_RS01395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HME7025_RS01405	COG4771	TonB-dependent receptor
HME7025_RS01430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HME7025_RS01435	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HME7025_RS01440	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HME7025_RS01445	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HME7025_RS01455	COG2271	Major facilitator Superfamily
HME7025_RS01460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HME7025_RS01470	COG1904	glucuronate isomerase
HME7025_RS01475	COG0246	Mannitol dehydrogenase
HME7025_RS01495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HME7025_RS01500	COG0085	RNA polymerase activity
HME7025_RS01510	COG1012	belongs to the aldehyde dehydrogenase family
HME7025_RS01555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HME7025_RS01560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HME7025_RS01575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HME7025_RS01580	COG0222	ribosome binding
HME7025_RS01585	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HME7025_RS01590	COG0081	regulation of translation
HME7025_RS01595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HME7025_RS01660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HME7025_RS01670	COG2322	membrane
HME7025_RS01685	COG1845	cytochrome c oxidase, subunit III
HME7025_RS01690	COG1845	cytochrome c oxidase, subunit III
HME7025_RS01695	COG0109	protoheme IX farnesyltransferase activity
HME7025_RS01705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HME7025_RS01710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HME7025_RS01735	COG0437	4 iron, 4 sulfur cluster binding
HME7025_RS01760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HME7025_RS01765	COG1473	amidohydrolase
HME7025_RS01785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HME7025_RS01790	COG5002	protein histidine kinase activity
HME7025_RS01800	COG0346	lactoylglutathione lyase activity
HME7025_RS01805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HME7025_RS01810	COG0512	Glutamine amidotransferase of anthranilate synthase
HME7025_RS01810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HME7025_RS01815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HME7025_RS01820	COG0134	indole-3-glycerol-phosphate synthase activity
HME7025_RS01825	COG0135	phosphoribosylanthranilate isomerase activity
HME7025_RS01830	COG0133	tryptophan synthase activity
HME7025_RS01835	COG0159	tryptophan synthase activity
HME7025_RS01840	COG0335	large ribosomal subunit rRNA binding
HME7025_RS01850	COG1136	(ABC) transporter
HME7025_RS01865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HME7025_RS01870	COG1040	competence protein
HME7025_RS01875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HME7025_RS01875	COG0515	serine threonine protein kinase
HME7025_RS01880	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HME7025_RS01895	COG0861	Integral membrane protein TerC family
HME7025_RS01935	COG4628	conserved protein (DUF2132)
HME7025_RS01940	COG0488	(ABC) transporter
HME7025_RS01945	COG0805	protein transport
HME7025_RS01950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HME7025_RS01980	COG0656	L-ascorbic acid biosynthetic process
HME7025_RS01990	COG1649	PFAM Uncharacterised BCR, COG1649
HME7025_RS01995	COG0745	RESPONSE REGULATOR receiver
HME7025_RS02000	COG0628	permease
HME7025_RS02005	COG3279	Response regulator of the LytR AlgR family
HME7025_RS02010	COG3275	phosphorelay sensor kinase activity
HME7025_RS02015	COG0406	alpha-ribazole phosphatase activity
HME7025_RS02020	COG2050	protein possibly involved in aromatic compounds catabolism
HME7025_RS02035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HME7025_RS02040	COG0431	NADPH-dependent FMN reductase
HME7025_RS02050	COG1253	flavin adenine dinucleotide binding
HME7025_RS02085	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HME7025_RS02085	COG1918	ferrous iron import across plasma membrane
HME7025_RS02105	COG1809	phosphosulfolactate synthase activity
HME7025_RS02110	COG0586	Pfam SNARE associated Golgi protein
HME7025_RS02115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HME7025_RS02120	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HME7025_RS02130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HME7025_RS02155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HME7025_RS02160	COG0590	tRNA wobble adenosine to inosine editing
HME7025_RS02165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HME7025_RS02195	COG0662	Cupin 2, conserved barrel domain protein
HME7025_RS02195	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HME7025_RS02200	COG4771	TonB-dependent receptor
HME7025_RS02205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HME7025_RS02230	COG0247	lactate metabolic process
HME7025_RS02230	COG2181	nitrate reductase activity
HME7025_RS02240	COG1956	GAF domain-containing protein
HME7025_RS02245	COG2318	DinB family
HME7025_RS02250	COG0688	phosphatidylethanolamine metabolic process
HME7025_RS02275	COG0314	molybdopterin synthase activity
HME7025_RS02280	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HME7025_RS02315	COG1538	Outer membrane efflux protein
HME7025_RS02320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HME7025_RS02325	COG0438	transferase activity, transferring glycosyl groups
HME7025_RS02335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HME7025_RS02335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HME7025_RS02340	COG1678	Uncharacterized ACR, COG1678
HME7025_RS02345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HME7025_RS02355	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HME7025_RS02360	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HME7025_RS02375	COG1215	transferase activity, transferring glycosyl groups
HME7025_RS02380	COG1132	(ABC) transporter
HME7025_RS02385	COG0436	Aminotransferase
HME7025_RS02390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HME7025_RS02400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HME7025_RS02405	COG0275	rRNA processing
HME7025_RS02415	COG0768	penicillin binding
HME7025_RS02420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HME7025_RS02425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HME7025_RS02435	COG1228	amidohydrolase
HME7025_RS02445	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HME7025_RS02450	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HME7025_RS02465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HME7025_RS02470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HME7025_RS02490	COG0360	Binds together with S18 to 16S ribosomal RNA
HME7025_RS02495	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HME7025_RS02500	COG0359	binds to the 23S rRNA
HME7025_RS02505	COG0538	isocitrate dehydrogenase activity
HME7025_RS02510	COG0788	formyltetrahydrofolate deformylase activity
HME7025_RS02515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HME7025_RS02530	COG0242	peptide deformylase activity
HME7025_RS02535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HME7025_RS02540	COG0616	signal peptide processing
HME7025_RS02545	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HME7025_RS02560	COG1418	mRNA catabolic process
HME7025_RS02580	COG3279	Response regulator of the LytR AlgR family
HME7025_RS02585	COG2972	Histidine kinase
HME7025_RS02585	COG0745	RESPONSE REGULATOR receiver
HME7025_RS02605	COG0022	dehydrogenase e1 component
HME7025_RS02620	COG0713	ATP synthesis coupled electron transport
HME7025_RS02625	COG0322	excinuclease ABC activity
HME7025_RS02630	COG1629	transport
HME7025_RS02635	COG0702	epimerase
HME7025_RS02650	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HME7025_RS02665	COG0768	penicillin binding
HME7025_RS02670	COG0772	Belongs to the SEDS family
HME7025_RS02675	COG0477	Major facilitator Superfamily
HME7025_RS02685	COG2363	Small membrane protein
HME7025_RS02690	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HME7025_RS02695	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HME7025_RS02700	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HME7025_RS02705	COG0356	it plays a direct role in the translocation of protons across the membrane
HME7025_RS02715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HME7025_RS02720	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_RS02725	COG2211	Major facilitator Superfamily
HME7025_RS02745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HME7025_RS02750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HME7025_RS02755	COG4771	TonB-dependent receptor
HME7025_RS02790	COG1960	acyl-CoA dehydrogenase activity
HME7025_RS02800	COG0287	Prephenate dehydrogenase
HME7025_RS02820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HME7025_RS02825	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_RS02830	COG0429	hydrolase of the alpha beta-hydrolase fold
HME7025_RS02835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HME7025_RS02840	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HME7025_RS02845	COG0673	inositol 2-dehydrogenase activity
HME7025_RS02865	COG0217	transcriptional regulatory protein
HME7025_RS02890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HME7025_RS02895	COG4771	TonB-dependent receptor
HME7025_RS02910	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HME7025_RS02920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HME7025_RS02925	COG2816	NAD+ diphosphatase activity
HME7025_RS02940	COG1846	Transcriptional regulator
HME7025_RS02940	COG1940	carbohydrate kinase activity
HME7025_RS02960	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HME7025_RS02970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HME7025_RS03005	COG3386	PFAM SMP-30 Gluconolaconase
HME7025_RS03020	COG2890	protein-(glutamine-N5) methyltransferase activity
HME7025_RS03040	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HME7025_RS03055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HME7025_RS03060	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HME7025_RS03070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HME7025_RS03075	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HME7025_RS03080	COG0052	Belongs to the universal ribosomal protein uS2 family
HME7025_RS03085	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HME7025_RS03090	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HME7025_RS03095	COG0439	Biotin carboxylase
HME7025_RS03100	COG0511	ligase activity, forming carbon-carbon bonds
HME7025_RS03105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HME7025_RS03110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HME7025_RS03115	COG0416	fatty acid biosynthetic process
HME7025_RS03120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HME7025_RS03135	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HME7025_RS03140	COG0105	UTP biosynthetic process
HME7025_RS03150	COG0545	Peptidyl-prolyl cis-trans isomerase
HME7025_RS03165	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HME7025_RS03175	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HME7025_RS03185	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HME7025_RS03200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HME7025_RS03205	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HME7025_RS03210	COG0516	GMP reductase activity
HME7025_RS03210	COG0517	IMP dehydrogenase activity
HME7025_RS03225	COG0673	inositol 2-dehydrogenase activity
HME7025_RS03230	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HME7025_RS03235	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HME7025_RS03245	COG0649	NAD binding
HME7025_RS03250	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HME7025_RS03265	COG1034	ATP synthesis coupled electron transport
HME7025_RS03270	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HME7025_RS03275	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HME7025_RS03280	COG0839	Belongs to the complex I subunit 6 family
HME7025_RS03295	COG2972	Histidine kinase
HME7025_RS03295	COG0745	RESPONSE REGULATOR receiver
HME7025_RS03300	COG3279	Response regulator of the LytR AlgR family
HME7025_RS03320	COG0438	transferase activity, transferring glycosyl groups
HME7025_RS03340	COG0438	transferase activity, transferring glycosyl groups
HME7025_RS03345	COG1088	dTDP-glucose 4,6-dehydratase activity
HME7025_RS03360	COG0612	Peptidase, M16
HME7025_RS03365	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HME7025_RS03370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HME7025_RS03380	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HME7025_RS03390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HME7025_RS03420	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HME7025_RS03470	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HME7025_RS03475	COG0489	protein tyrosine kinase activity
HME7025_RS03495	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HME7025_RS03510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HME7025_RS03515	COG0531	amino acid
HME7025_RS03520	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HME7025_RS03525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HME7025_RS03535	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HME7025_RS03585	COG0006	proline dipeptidase activity
HME7025_RS03615	COG1309	transcriptional regulator
HME7025_RS03630	COG3940	Belongs to the glycosyl hydrolase 43 family
HME7025_RS03645	COG4989	oxidoreductase activity
HME7025_RS03655	COG0494	nUDIX hydrolase
HME7025_RS03660	COG2989	Protein conserved in bacteria
HME7025_RS03690	COG1082	Xylose isomerase domain protein TIM barrel
HME7025_RS03720	COG2382	esterase
HME7025_RS03730	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HME7025_RS03735	COG3119	arylsulfatase activity
HME7025_RS03765	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HME7025_RS03780	COG2133	pyrroloquinoline quinone binding
HME7025_RS03805	COG1104	cysteine desulfurase activity
HME7025_RS03830	COG4783	chaperone-mediated protein folding
HME7025_RS03870	COG1629	transport
HME7025_RS03910	COG2081	HI0933 family
HME7025_RS03950	COG0667	Aldo Keto reductase
HME7025_RS03955	COG1063	alcohol dehydrogenase
HME7025_RS03960	COG1082	Xylose isomerase domain protein TIM barrel
HME7025_RS03965	COG3254	rhamnose metabolic process
HME7025_RS03975	COG0673	inositol 2-dehydrogenase activity
HME7025_RS03980	COG0584	glycerophosphoryl diester phosphodiesterase
HME7025_RS03990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HME7025_RS04000	COG0667	Aldo Keto reductase
HME7025_RS04020	COG1607	acyl-coa hydrolase
HME7025_RS04025	COG1648	precorrin-2 dehydrogenase activity
HME7025_RS04025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HME7025_RS04030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HME7025_RS04045	COG2223	nitrite transmembrane transporter activity
HME7025_RS04050	COG0243	molybdopterin cofactor binding
HME7025_RS04060	COG1773	rubredoxin
HME7025_RS04065	COG0746	molybdenum cofactor guanylyltransferase activity
HME7025_RS04075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HME7025_RS04095	COG1404	Belongs to the peptidase S8 family
HME7025_RS04120	COG0415	Belongs to the DNA photolyase family
HME7025_RS04125	COG3046	protein related to deoxyribodipyrimidine photolyase
HME7025_RS04130	COG3693	PFAM glycoside hydrolase, family 10
HME7025_RS04130	COG3507	Belongs to the glycosyl hydrolase 43 family
HME7025_RS04130	COG2382	esterase
HME7025_RS04135	COG3119	arylsulfatase activity
HME7025_RS04145	COG0861	Integral membrane protein TerC family
HME7025_RS04155	COG0592	DNA-directed DNA polymerase activity
HME7025_RS04165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HME7025_RS04170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HME7025_RS04175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HME7025_RS04180	COG0137	argininosuccinate synthase activity
HME7025_RS04190	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HME7025_RS04200	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HME7025_RS04235	COG0653	protein targeting
HME7025_RS04265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HME7025_RS04270	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HME7025_RS04285	COG0513	Belongs to the DEAD box helicase family
HME7025_RS04290	COG0783	Belongs to the Dps family
HME7025_RS04300	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HME7025_RS04310	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HME7025_RS04320	COG0251	oxidation-reduction process
HME7025_RS04325	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HME7025_RS04325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HME7025_RS04335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HME7025_RS04340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HME7025_RS04345	COG0022	dehydrogenase e1 component
HME7025_RS04345	COG0508	dehydrogenase complex catalyzes the overall conversion of
HME7025_RS04350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HME7025_RS04355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HME7025_RS04360	COG1278	Cold shock
HME7025_RS04375	COG0531	amino acid
HME7025_RS04385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HME7025_RS04385	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HME7025_RS04395	COG0297	glycogen (starch) synthase activity
HME7025_RS04405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HME7025_RS04415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HME7025_RS04415	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HME7025_RS04435	COG1127	ABC transporter
HME7025_RS04440	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HME7025_RS04460	COG0571	ribonuclease III activity
HME7025_RS04465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HME7025_RS04470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HME7025_RS04475	COG1940	carbohydrate kinase activity
HME7025_RS04485	COG1435	thymidine kinase activity
HME7025_RS04495	COG1053	succinate dehydrogenase
HME7025_RS04520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HME7025_RS04540	COG1629	transport
HME7025_RS04550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HME7025_RS04550	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HME7025_RS04595	COG1902	pentaerythritol trinitrate reductase activity
HME7025_RS04600	COG1733	regulation of RNA biosynthetic process
HME7025_RS04605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HME7025_RS04610	COG1104	cysteine desulfurase activity
HME7025_RS04615	COG0442	prolyl-tRNA aminoacylation
HME7025_RS04630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HME7025_RS04645	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HME7025_RS04655	COG0521	Mo-molybdopterin cofactor biosynthetic process
HME7025_RS04660	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HME7025_RS04670	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HME7025_RS04675	COG3341	Caulimovirus viroplasmin
HME7025_RS04675	COG0328	RNA-DNA hybrid ribonuclease activity
HME7025_RS04680	COG2095	MarC family integral membrane protein
HME7025_RS04685	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HME7025_RS04690	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HME7025_RS04695	COG4974	Belongs to the 'phage' integrase family
HME7025_RS04710	COG0802	atpase or kinase
HME7025_RS04715	COG0300	oxidoreductase activity
HME7025_RS04720	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HME7025_RS04740	COG0167	dihydroorotate dehydrogenase activity
HME7025_RS04745	COG1674	ftsk spoiiie
HME7025_RS04755	COG0047	phosphoribosylformylglycinamidine synthase activity
HME7025_RS04770	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HME7025_RS04785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HME7025_RS04795	COG0730	response to heat
HME7025_RS04800	COG0495	leucyl-tRNA aminoacylation
HME7025_RS04805	COG3119	arylsulfatase activity
HME7025_RS04820	COG1082	Xylose isomerase domain protein TIM barrel
HME7025_RS04845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HME7025_RS04880	COG1032	radical SAM domain protein
HME7025_RS04885	COG2824	Alkylphosphonate utilization operon protein PhnA
HME7025_RS04950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HME7025_RS04955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HME7025_RS04965	COG2096	Adenosyltransferase
HME7025_RS04970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HME7025_RS04985	COG1022	Amp-dependent synthetase and ligase
HME7025_RS04995	COG0799	negative regulation of ribosome biogenesis
HME7025_RS05000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HME7025_RS05010	COG1621	beta-fructofuranosidase activity
HME7025_RS05030	COG4152	abc transporter atp-binding protein
HME7025_RS05035	COG1668	transmembrane transport
HME7025_RS05045	COG2860	membrane
HME7025_RS05055	COG1393	Belongs to the ArsC family
HME7025_RS05060	COG0114	fumarate hydratase activity
HME7025_RS05070	COG0640	Transcriptional regulator
HME7025_RS05075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HME7025_RS05080	COG0126	phosphoglycerate kinase activity
HME7025_RS05095	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HME7025_RS05105	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HME7025_RS05115	COG3118	belongs to the thioredoxin family
HME7025_RS05125	COG1162	GTPase activity
HME7025_RS05130	COG1940	carbohydrate kinase activity
HME7025_RS05165	COG2183	response to ionizing radiation
HME7025_RS05175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HME7025_RS05180	COG0587	DNA-directed DNA polymerase activity
HME7025_RS05205	COG2135	peptidase activity
HME7025_RS05220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HME7025_RS05225	COG3118	belongs to the thioredoxin family
HME7025_RS05225	COG0492	ferredoxin-NADP+ reductase activity
HME7025_RS05245	COG0500	methyltransferase
HME7025_RS05260	COG3258	Cytochrome c
HME7025_RS05300	COG1054	Belongs to the UPF0176 family
HME7025_RS05305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HME7025_RS05305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HME7025_RS05310	COG0730	response to heat
HME7025_RS05325	COG0673	inositol 2-dehydrogenase activity
HME7025_RS05335	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HME7025_RS05335	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HME7025_RS05360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HME7025_RS05365	COG1119	ATPase activity
HME7025_RS05370	COG0006	proline dipeptidase activity
HME7025_RS05380	COG1629	transport
HME7025_RS05385	COG0702	epimerase
HME7025_RS05425	COG1129	ABC transporter
HME7025_RS05430	COG1172	Belongs to the binding-protein-dependent transport system permease family
HME7025_RS05435	COG1879	ABC-type sugar transport system periplasmic component
HME7025_RS05455	COG1473	amidohydrolase
HME7025_RS05485	COG1215	transferase activity, transferring glycosyl groups
HME7025_RS05495	COG2205	protein histidine kinase activity
HME7025_RS05495	COG0784	Response regulator, receiver
HME7025_RS05530	COG0423	glycine-tRNA ligase activity
HME7025_RS05535	COG0859	PFAM glycosyl transferase family 9
HME7025_RS05550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HME7025_RS05550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HME7025_RS05555	COG0259	pyridoxamine-phosphate oxidase activity
HME7025_RS05575	COG0739	heme binding
HME7025_RS05580	COG0492	ferredoxin-NADP+ reductase activity
HME7025_RS05585	COG1301	dicarboxylic acid transport
HME7025_RS05590	COG0281	malic enzyme
HME7025_RS05590	COG0280	phosphate acetyltransferase
HME7025_RS05605	COG3876	Protein conserved in bacteria
HME7025_RS05610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HME7025_RS05610	COG0519	Catalyzes the synthesis of GMP from XMP
HME7025_RS05615	COG2195	Cleaves the N-terminal amino acid of tripeptides
HME7025_RS05625	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HME7025_RS05625	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HME7025_RS05635	COG0602	queuosine metabolic process
HME7025_RS05650	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HME7025_RS05665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HME7025_RS05670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HME7025_RS05675	COG0714	Associated with various cellular activities
HME7025_RS05680	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HME7025_RS05710	COG3609	addiction module antidote protein, CC2985 family
HME7025_RS05725	COG2308	Evidence 4 Homologs of previously reported genes of
HME7025_RS05730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HME7025_RS05735	COG1796	DNA polymerase
HME7025_RS05735	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HME7025_RS05740	COG1611	Belongs to the LOG family
HME7025_RS05745	COG0698	ribose 5-phosphate isomerase
HME7025_RS05755	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HME7025_RS05760	COG4591	ABC-type transport system involved in lipoprotein release permease component
HME7025_RS05765	COG1301	dicarboxylic acid transport
HME7025_RS05800	COG0746	molybdenum cofactor guanylyltransferase activity
HME7025_RS05805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HME7025_RS05810	COG0101	tRNA pseudouridine synthase activity
HME7025_RS05815	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HME7025_RS05825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HME7025_RS05835	COG0484	heat shock protein binding
HME7025_RS05840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HME7025_RS05845	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HME7025_RS05855	COG0745	RESPONSE REGULATOR receiver
HME7025_RS05855	COG2205	protein histidine kinase activity
HME7025_RS05855	COG3292	Two component regulator propeller
HME7025_RS05880	COG0482	sulfurtransferase activity
HME7025_RS05895	COG0408	coproporphyrinogen oxidase activity
HME7025_RS05910	COG1663	tetraacyldisaccharide 4'-kinase activity
HME7025_RS05920	COG1943	Transposase
HME7025_RS05935	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HME7025_RS05945	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HME7025_RS06025	COG1309	transcriptional regulator
HME7025_RS06055	COG0004	ammonium transporteR
HME7025_RS06060	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HME7025_RS06075	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HME7025_RS06080	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HME7025_RS06090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HME7025_RS06100	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HME7025_RS06115	COG3254	rhamnose metabolic process
HME7025_RS06140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HME7025_RS06170	COG0686	Belongs to the AlaDH PNT family
HME7025_RS06180	COG2814	Major facilitator Superfamily
HME7025_RS06185	COG1566	PFAM secretion protein HlyD family protein
HME7025_RS06205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HME7025_RS06210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HME7025_RS06220	COG0758	DNA mediated transformation
HME7025_RS06225	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HME7025_RS06235	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HME7025_RS06245	COG0488	(ABC) transporter
HME7025_RS06250	COG0673	inositol 2-dehydrogenase activity
HME7025_RS06255	COG1012	belongs to the aldehyde dehydrogenase family
HME7025_RS06275	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HME7025_RS06280	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HME7025_RS06285	COG0415	Belongs to the DNA photolyase family
HME7025_RS06295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HME7025_RS06300	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HME7025_RS06320	COG0156	8-amino-7-oxononanoate synthase activity
HME7025_RS06325	COG0405	Gamma-glutamyltransferase
HME7025_RS06335	COG3104	oligopeptide transport
HME7025_RS06340	COG1192	Involved in chromosome partitioning
HME7025_RS06345	COG1475	DNA binding
HME7025_RS06355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HME7025_RS06370	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HME7025_RS06380	COG0268	Binds directly to 16S ribosomal RNA
HME7025_RS06385	COG2003	Belongs to the UPF0758 family
HME7025_RS06390	COG0131	Imidazoleglycerol-phosphate dehydratase
HME7025_RS06390	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HME7025_RS06400	COG0513	Belongs to the DEAD box helicase family
HME7025_RS06410	COG2967	ApaG domain
HME7025_RS06415	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HME7025_RS06425	COG0247	lactate metabolic process
HME7025_RS06425	COG0277	FAD linked oxidase domain protein
HME7025_RS06430	COG1136	(ABC) transporter
HME7025_RS06430	COG0577	efflux transmembrane transporter activity
HME7025_RS06435	COG0039	L-malate dehydrogenase activity
HME7025_RS06445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HME7025_RS06450	COG0154	amidase activity
HME7025_RS06455	COG0791	NLP P60 protein
HME7025_RS06455	COG1388	LysM domain
HME7025_RS06460	COG0632	four-way junction helicase activity
HME7025_RS06475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HME7025_RS06495	COG1131	(ABC) transporter
HME7025_RS06500	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HME7025_RS06505	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HME7025_RS06505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HME7025_RS06510	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HME7025_RS06515	COG1078	dGTPase activity
HME7025_RS06535	COG0277	FAD linked oxidase domain protein
HME7025_RS06555	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HME7025_RS06560	COG0066	3-isopropylmalate dehydratase activity
HME7025_RS06570	COG0473	3-isopropylmalate dehydrogenase activity
HME7025_RS06580	COG1506	peptidase
HME7025_RS06580	COG4946	Tricorn protease homolog
HME7025_RS06580	COG0823	Involved in the tonB-independent uptake of proteins
HME7025_RS06585	COG1363	Peptidase, m42
HME7025_RS06590	COG0205	6-phosphofructokinase activity
HME7025_RS06595	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HME7025_RS06610	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HME7025_RS06620	COG0012	GTP binding
HME7025_RS06630	COG0488	(ABC) transporter
HME7025_RS06635	COG0069	glutamate synthase activity
HME7025_RS06640	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HME7025_RS06645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HME7025_RS06660	COG0009	L-threonylcarbamoyladenylate synthase
HME7025_RS06675	COG0542	response to heat
HME7025_RS06680	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_RS06700	COG0228	four-way junction DNA binding
HME7025_RS06705	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HME7025_RS06710	COG0336	Belongs to the RNA methyltransferase TrmD family
HME7025_RS06715	COG0697	spore germination
HME7025_RS06720	COG2755	lipolytic protein G-D-S-L family
HME7025_RS06720	COG0657	acetylesterase activity
HME7025_RS06725	COG0531	amino acid
HME7025_RS06735	COG1629	transport
HME7025_RS06750	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HME7025_RS06755	COG0825	malonyl-CoA metabolic process
HME7025_RS06760	COG1011	Hydrolase
HME7025_RS06770	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HME7025_RS06780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HME7025_RS06785	COG1216	Glycosyl transferase, family 2
HME7025_RS06790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HME7025_RS06795	COG0706	membrane insertase activity
HME7025_RS06800	COG0504	CTP synthase activity
HME7025_RS06835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HME7025_RS06840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HME7025_RS06845	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HME7025_RS06850	COG0508	dehydrogenase complex catalyzes the overall conversion of
HME7025_RS06855	COG0481	GTPase activity
HME7025_RS06860	COG0006	proline dipeptidase activity
HME7025_RS06865	COG2226	methyltransferase
HME7025_RS06875	COG0124	histidyl-tRNA synthetase
HME7025_RS06880	COG0166	Belongs to the GPI family
HME7025_RS06890	COG0450	alkyl hydroperoxide reductase
HME7025_RS06900	COG0719	Fe-S assembly protein
HME7025_RS06910	COG0564	pseudouridine synthase activity
HME7025_RS06915	COG0456	acetyltransferase
HME7025_RS06920	COG2814	Major facilitator Superfamily
HME7025_RS06925	COG0738	Major facilitator superfamily
HME7025_RS06930	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HME7025_RS06935	COG0459	protein refolding
HME7025_RS06940	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HME7025_RS06960	COG3604	Transcriptional regulator
HME7025_RS06965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HME7025_RS06970	COG1136	(ABC) transporter
HME7025_RS06975	COG0045	succinate-CoA ligase (ADP-forming) activity
HME7025_RS06980	COG0179	Fumarylacetoacetate (FAA) hydrolase
HME7025_RS06985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HME7025_RS06990	COG3959	Transketolase, thiamine diphosphate binding domain
HME7025_RS06995	COG3958	Transketolase
HME7025_RS07005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HME7025_RS07015	COG0436	Aminotransferase
HME7025_RS07030	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HME7025_RS07040	COG0069	glutamate synthase activity
HME7025_RS07040	COG0070	glutamate synthase
HME7025_RS07040	COG0067	glutamate synthase
HME7025_RS07070	COG0438	transferase activity, transferring glycosyl groups
HME7025_RS07075	COG0438	transferase activity, transferring glycosyl groups
HME7025_RS07085	COG0110	maltose O-acetyltransferase activity
HME7025_RS07090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HME7025_RS07095	COG0297	glycogen (starch) synthase activity
HME7025_RS07100	COG1605	Chorismate mutase
HME7025_RS07100	COG0077	Prephenate dehydratase
HME7025_RS07105	COG0196	riboflavin kinase activity
HME7025_RS07110	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HME7025_RS07115	COG1968	undecaprenyl-diphosphatase activity
HME7025_RS07125	COG2177	Part of the ABC transporter FtsEX involved in
HME7025_RS07135	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HME7025_RS07190	COG0577	efflux transmembrane transporter activity
HME7025_RS07210	COG0084	hydrolase, TatD family'
HME7025_RS07215	COG0726	polysaccharide deacetylase
HME7025_RS07220	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HME7025_RS07225	COG1331	Highly conserved protein containing a thioredoxin domain
HME7025_RS07230	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HME7025_RS07250	COG0583	DNA-binding transcription factor activity
HME7025_RS07260	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HME7025_RS07270	COG0463	Glycosyl transferase, family 2
HME7025_RS07285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HME7025_RS07290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HME7025_RS07295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HME7025_RS07315	COG0738	Major facilitator superfamily
HME7025_RS07325	COG2721	sulfolactate sulfo-lyase activity
HME7025_RS07330	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_RS07350	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_RS07365	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_RS07370	COG0129	dihydroxy-acid dehydratase activity
HME7025_RS07395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HME7025_RS07410	COG0443	Heat shock 70 kDa protein
HME7025_RS07415	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HME7025_RS07425	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HME7025_RS07430	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HME7025_RS07435	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HME7025_RS07440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HME7025_RS07465	COG0318	PFAM AMP-dependent synthetase and ligase
HME7025_RS07475	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HME7025_RS07490	COG0116	Belongs to the methyltransferase superfamily
HME7025_RS07490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HME7025_RS07495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HME7025_RS07515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HME7025_RS07520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HME7025_RS07525	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HME7025_RS07535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HME7025_RS07540	COG3118	belongs to the thioredoxin family
HME7025_RS07555	COG0180	Tryptophanyl-tRNA synthetase
HME7025_RS07560	COG0671	phosphoesterase, PA-phosphatase related
HME7025_RS07570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HME7025_RS07580	COG0004	ammonium transporteR
HME7025_RS07585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HME7025_RS07590	COG0174	glutamine synthetase
HME7025_RS07605	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HME7025_RS07625	COG0508	dehydrogenase complex catalyzes the overall conversion of
HME7025_RS07630	COG1058	Belongs to the CinA family
HME7025_RS07630	COG1546	Belongs to the CinA family
HME7025_RS07650	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HME7025_RS07660	COG0673	inositol 2-dehydrogenase activity
HME7025_RS07665	COG0720	synthase
HME7025_RS07670	COG0302	gtp cyclohydrolase
HME7025_RS07675	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_RS07680	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HME7025_RS07685	COG0494	nUDIX hydrolase
HME7025_RS07690	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HME7025_RS07700	COG0813	purine-nucleoside phosphorylase activity
HME7025_RS07715	COG1054	Belongs to the UPF0176 family
HME7025_RS07735	COG2153	protein acetylation
HME7025_RS07740	COG1702	phosphate starvation-inducible protein PhoH
HME7025_RS07750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HME7025_RS07755	COG0300	oxidoreductase activity
HME7025_RS07765	COG2217	Heavy metal translocating P-type atpase
HME7025_RS07775	COG3278	Belongs to the heme-copper respiratory oxidase family
HME7025_RS07805	COG4232	protein-disulfide reductase activity
HME7025_RS07815	COG4191	Histidine kinase
HME7025_RS07835	COG0659	secondary active sulfate transmembrane transporter activity
HME7025_RS07840	COG3002	Belongs to the UPF0753 family
HME7025_RS07845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HME7025_RS07855	COG0673	inositol 2-dehydrogenase activity
HME7025_RS07870	COG2366	antibiotic biosynthetic process
HME7025_RS07875	COG1250	3-hydroxyacyl-CoA dehydrogenase
HME7025_RS07890	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_RS07895	COG1063	alcohol dehydrogenase
HME7025_RS07915	COG1368	sulfuric ester hydrolase activity
HME7025_RS07945	COG2271	Major facilitator Superfamily
HME7025_RS07950	COG1063	alcohol dehydrogenase
HME7025_RS07960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HME7025_RS07985	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HME7025_RS08035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HME7025_RS08040	COG1185	polyribonucleotide nucleotidyltransferase activity
HME7025_RS08045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HME7025_RS08050	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HME7025_RS08060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HME7025_RS08095	COG0285	dihydrofolate synthase activity
HME7025_RS08100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HME7025_RS08105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HME7025_RS08110	COG2171	N-acyltransferase activity
HME7025_RS08115	COG2996	Protein conserved in bacteria
HME7025_RS08135	COG5002	protein histidine kinase activity
HME7025_RS08170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HME7025_RS08175	COG3599	regulation of cell shape
HME7025_RS08195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HME7025_RS08220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HME7025_RS08225	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HME7025_RS08235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HME7025_RS08240	COG2353	YceI-like domain
HME7025_RS08295	COG0673	inositol 2-dehydrogenase activity
HME7025_RS08320	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HME7025_RS08330	COG0284	orotidine-5'-phosphate decarboxylase activity
HME7025_RS08345	COG0540	Belongs to the ATCase OTCase family
HME7025_RS08355	COG0612	Peptidase, M16
HME7025_RS08360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HME7025_RS08365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HME7025_RS08380	COG1388	LysM domain
HME7025_RS08380	COG1705	Flagellar rod assembly protein muramidase FlgJ
HME7025_RS08390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HME7025_RS08410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HME7025_RS08415	COG4221	oxidoreductase activity
HME7025_RS08420	COG0193	aminoacyl-tRNA hydrolase activity
HME7025_RS08430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HME7025_RS08430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HME7025_RS08435	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HME7025_RS08440	COG4974	Belongs to the 'phage' integrase family
HME7025_RS08445	COG0083	homoserine kinase activity
HME7025_RS08450	COG0527	aspartate kinase activity
HME7025_RS08450	COG0460	homoserine dehydrogenase
HME7025_RS08455	COG2323	membrane
HME7025_RS08460	COG0848	biopolymer transport protein
HME7025_RS08470	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HME7025_RS08470	COG0248	Ppx GppA phosphatase
HME7025_RS08480	COG0612	Peptidase, M16
HME7025_RS08490	COG2151	metal-sulfur cluster biosynthetic enzyme
HME7025_RS08495	COG2166	iron-sulfur cluster assembly
HME7025_RS08500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HME7025_RS08505	COG0719	Fe-S assembly protein
HME7025_RS08510	COG0396	ATPase activity
HME7025_RS08515	COG0316	Belongs to the HesB IscA family
HME7025_RS08530	COG2353	YceI-like domain
HME7025_RS08535	COG0778	Nitroreductase
HME7025_RS08545	COG0009	L-threonylcarbamoyladenylate synthase
HME7025_RS08550	COG0018	arginyl-trna synthetase
HME7025_RS08555	COG0386	Belongs to the glutathione peroxidase family
HME7025_RS08560	COG1575	Belongs to the MenA family. Type 1 subfamily
HME7025_RS08590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HME7025_RS08600	COG0709	Synthesizes selenophosphate from selenide and ATP
HME7025_RS08605	COG2267	carboxylic ester hydrolase activity
HME7025_RS08610	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HME7025_RS08615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HME7025_RS08620	COG1183	phosphatidylcholine synthase activity
HME7025_RS08625	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HME7025_RS08640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HME7025_RS08650	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HME7025_RS08660	COG4932	domain protein
HME7025_RS08660	COG1388	LysM domain
HME7025_RS08680	COG0248	Ppx GppA phosphatase
HME7025_RS08690	COG2204	response regulator
HME7025_RS08695	COG2884	Cell division ATP-binding protein ftsE
HME7025_RS08700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HME7025_RS08745	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HME7025_RS08750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HME7025_RS08760	COG1047	Peptidyl-prolyl cis-trans
HME7025_RS08770	COG1561	YicC-like family, N-terminal region
HME7025_RS08785	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HME7025_RS08800	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HME7025_RS08825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HME7025_RS08875	COG0024	Methionine aminopeptidase
HME7025_RS08890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HME7025_RS08910	COG1739	Uncharacterized protein family UPF0029
HME7025_RS08915	COG0179	Fumarylacetoacetate (FAA) hydrolase
HME7025_RS08925	COG4115	mRNA cleavage
HME7025_RS08935	COG0542	response to heat
HME7025_RS08940	COG2205	protein histidine kinase activity
HME7025_RS08940	COG0784	Response regulator, receiver
HME7025_RS08940	COG5002	protein histidine kinase activity
HME7025_RS08945	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HME7025_RS08950	COG2239	Acts as a magnesium transporter
HME7025_RS08955	COG1490	D-aminoacyl-tRNA deacylase activity
HME7025_RS08960	COG1694	Mazg nucleotide pyrophosphohydrolase
HME7025_RS08965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HME7025_RS08975	COG2610	gluconate transmembrane transporter activity
HME7025_RS09000	COG0673	inositol 2-dehydrogenase activity
HME7025_RS09050	COG4771	TonB-dependent receptor
HME7025_RS09060	COG4771	TonB-dependent receptor
HME7025_RS09085	COG4263	nitrous-oxide reductase activity
HME7025_RS09090	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HME7025_RS09105	COG1131	(ABC) transporter
HME7025_RS09125	COG0784	Response regulator, receiver
HME7025_RS09125	COG2205	protein histidine kinase activity
HME7025_RS09155	COG1024	Enoyl-CoA hydratase
HME7025_RS09170	COG0017	Asparaginyl-tRNA synthetase
HME7025_RS09175	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HME7025_RS09185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HME7025_RS09190	COG0534	Mate efflux family protein
HME7025_RS09210	COG0508	dehydrogenase complex catalyzes the overall conversion of
HME7025_RS09215	COG0567	Dehydrogenase, E1 component
HME7025_RS09230	COG0326	Molecular chaperone. Has ATPase activity
HME7025_RS09245	COG0037	tRNA processing
HME7025_RS09270	COG0352	thiamine-phosphate diphosphorylase activity
HME7025_RS09275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HME7025_RS09280	COG2226	methyltransferase
HME7025_RS09300	COG1132	(ABC) transporter
HME7025_RS09315	COG0793	Belongs to the peptidase S41A family
HME7025_RS09325	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HME7025_RS09330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HME7025_RS09340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HME7025_RS09355	COG2217	Heavy metal translocating P-type atpase
HME7025_RS09395	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HME7025_RS09400	COG0531	amino acid
HME7025_RS09415	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HME7025_RS09420	COG1012	belongs to the aldehyde dehydrogenase family
HME7025_RS09430	COG1064	alcohol dehydrogenase
HME7025_RS09445	COG1136	(ABC) transporter
HME7025_RS09450	COG3274	enterobacterial common antigen metabolic process
HME7025_RS09455	COG2010	Cytochrome c
HME7025_RS09455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HME7025_RS09470	COG0673	inositol 2-dehydrogenase activity
HME7025_RS09475	COG1556	Lactate utilization protein
HME7025_RS09480	COG1139	Iron-sulfur cluster binding protein
HME7025_RS09485	COG0247	lactate metabolic process
HME7025_RS09495	COG4952	isomerase
HME7025_RS09500	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_RS09500	COG3347	Dehydrogenase
HME7025_RS09505	COG1473	amidohydrolase
HME7025_RS09515	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HME7025_RS09525	COG0315	cyclic pyranopterin monophosphate synthase activity
HME7025_RS09530	COG0303	'Molybdopterin
HME7025_RS09535	COG4948	Mandelate Racemase Muconate Lactonizing
HME7025_RS09545	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HME7025_RS09580	COG3622	Belongs to the hyi family
HME7025_RS09585	COG0640	Transcriptional regulator
HME7025_RS09605	COG3217	Mosc domain protein beta barrel domain protein
HME7025_RS09605	COG0633	Ferredoxin
HME7025_RS09615	COG1132	(ABC) transporter
HME7025_RS09620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HME7025_RS09635	COG1862	Preprotein translocase
HME7025_RS09645	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HME7025_RS09670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HME7025_RS09685	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HME7025_RS09690	COG2267	carboxylic ester hydrolase activity
HME7025_RS09700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HME7025_RS09710	COG0544	peptidyl-prolyl cis-trans isomerase activity
HME7025_RS09725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HME7025_RS09740	COG0673	inositol 2-dehydrogenase activity
HME7025_RS09750	COG0358	DNA primase activity
HME7025_RS09755	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HME7025_RS09760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HME7025_RS09770	COG0187	DNA topoisomerase II activity
HME7025_RS09775	COG0138	bifunctional purine biosynthesis protein purh
HME7025_RS09780	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HME7025_RS09785	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_RS09800	COG1917	Cupin 2, conserved barrel domain protein
HME7025_RS09800	COG2207	Transcriptional regulator
HME7025_RS09845	COG4221	oxidoreductase activity
HME7025_RS09855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HME7025_RS09875	COG1506	peptidase
HME7025_RS09875	COG0823	Involved in the tonB-independent uptake of proteins
HME7025_RS09880	COG3590	peptidase
HME7025_RS09885	COG0702	epimerase
HME7025_RS09890	COG1629	transport
HME7025_RS09900	COG4771	TonB-dependent receptor
HME7025_RS09905	COG2610	gluconate transmembrane transporter activity
HME7025_RS09935	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HME7025_RS09950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HME7025_RS09955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HME7025_RS09970	COG1496	oxidoreductase activity
HME7025_RS10010	COG0575	Belongs to the CDS family
HME7025_RS10025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HME7025_RS10050	COG0528	UMP kinase activity
HME7025_RS10055	COG0233	cytoplasmic translational termination
HME7025_RS10080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HME7025_RS10085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HME7025_RS10090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HME7025_RS10095	COG0165	Argininosuccinate lyase
HME7025_RS10125	COG4191	Histidine kinase
HME7025_RS10135	COG2226	methyltransferase
HME7025_RS10160	COG0363	glucosamine-6-phosphate deaminase activity
HME7025_RS10165	COG0277	FAD linked oxidase domain protein
HME7025_RS10165	COG0247	lactate metabolic process
HME7025_RS10175	COG0463	Glycosyl transferase, family 2
HME7025_RS10185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HME7025_RS10185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HME7025_RS10190	COG0254	rRNA binding
HME7025_RS10195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HME7025_RS10200	COG0470	DNA polymerase III
HME7025_RS10205	COG0181	hydroxymethylbilane synthase activity
HME7025_RS10210	COG1091	dTDP-4-dehydrorhamnose reductase activity
HME7025_RS10215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HME7025_RS10220	COG0563	adenylate kinase activity
HME7025_RS10225	COG4771	TonB-dependent receptor
HME7025_RS10235	COG0823	Involved in the tonB-independent uptake of proteins
HME7025_RS10245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HME7025_RS10285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HME7025_RS10310	COG0497	DNA recombination
HME7025_RS10320	COG1999	signal sequence binding
HME7025_RS10340	COG0668	transmembrane transport
HME7025_RS10345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HME7025_RS10350	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HME7025_RS10360	COG0028	Belongs to the TPP enzyme family
HME7025_RS10365	COG0129	dihydroxy-acid dehydratase activity
HME7025_RS10370	COG5265	(ABC) transporter
HME7025_RS10375	COG0579	oxidoreductase
HME7025_RS10380	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HME7025_RS10385	COG0564	pseudouridine synthase activity
HME7025_RS10395	COG4974	Belongs to the 'phage' integrase family
HME7025_RS10435	COG2217	Heavy metal translocating P-type atpase
HME7025_RS10445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HME7025_RS10460	COG2132	Multicopper oxidase
HME7025_RS10520	COG3458	cephalosporin-C deacetylase activity
HME7025_RS10535	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_RS10545	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HME7025_RS10600	COG4771	TonB-dependent receptor
HME7025_RS10625	COG4771	TonB-dependent receptor
HME7025_RS10650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HME7025_RS10660	COG1063	alcohol dehydrogenase
HME7025_RS10665	COG1131	(ABC) transporter
HME7025_RS10685	COG2315	Protein conserved in bacteria
HME7025_RS10700	COG0346	lactoylglutathione lyase activity
HME7025_RS10705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HME7025_RS10715	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HME7025_RS10715	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HME7025_RS10720	COG1024	Enoyl-CoA hydratase
HME7025_RS10720	COG1250	3-hydroxyacyl-CoA dehydrogenase
HME7025_RS10725	COG0183	Belongs to the thiolase family
HME7025_RS10730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HME7025_RS10735	COG3384	dioxygenase
HME7025_RS10740	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HME7025_RS10745	COG0156	8-amino-7-oxononanoate synthase activity
HME7025_RS10750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HME7025_RS10755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HME7025_RS10775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HME7025_RS10790	COG1007	ATP synthesis coupled electron transport
HME7025_RS10820	COG5180	pathogenesis
HME7025_RS10820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HME7025_RS10825	COG0195	Participates in both transcription termination and antitermination
HME7025_RS10830	COG0779	Required for maturation of 30S ribosomal subunits
HME7025_RS10835	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HME7025_RS10845	COG4206	TonB-dependent receptor
HME7025_RS10850	COG0519	Catalyzes the synthesis of GMP from XMP
HME7025_RS10855	COG0463	Glycosyl transferase, family 2
HME7025_RS10860	COG1981	membrane
HME7025_RS10865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HME7025_RS10885	COG1446	asparaginase
HME7025_RS10925	COG1595	DNA-templated transcription, initiation
HME7025_RS10965	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HME7025_RS10970	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HME7025_RS10980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HME7025_RS10985	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HME7025_RS10995	COG1595	DNA-templated transcription, initiation
HME7025_RS11005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HME7025_RS11015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HME7025_RS11035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HME7025_RS11070	COG2205	protein histidine kinase activity
HME7025_RS11080	COG2808	Putative FMN-binding domain
HME7025_RS11090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HME7025_RS11095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HME7025_RS11095	COG1648	precorrin-2 dehydrogenase activity
HME7025_RS11100	COG0251	oxidation-reduction process
HME7025_RS11105	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HME7025_RS11105	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HME7025_RS11110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HME7025_RS11120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HME7025_RS11125	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HME7025_RS11165	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HME7025_RS11180	COG0811	peptide transport
HME7025_RS11205	COG1619	proteins homologs of microcin C7 resistance protein MccF
HME7025_RS11210	COG0606	chelatase, subunit chli
HME7025_RS11225	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HME7025_RS11240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HME7025_RS11250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HME7025_RS11255	COG0527	aspartate kinase activity
HME7025_RS11260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HME7025_RS11280	COG2255	four-way junction helicase activity
HME7025_RS11285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HME7025_RS11290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HME7025_RS11300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HME7025_RS11310	COG0488	(ABC) transporter
HME7025_RS11320	COG0714	Associated with various cellular activities
HME7025_RS11325	COG2755	lipolytic protein G-D-S-L family
HME7025_RS11355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HME7025_RS11365	COG3158	transport of potassium into the cell
HME7025_RS11370	COG0412	Dienelactone hydrolase
HME7025_RS11385	COG0175	sulfate reduction
HME7025_RS11390	COG0175	sulfate reduction
HME7025_RS11405	COG0525	valine-tRNA ligase activity
HME7025_RS11415	COG1132	(ABC) transporter
HME7025_RS11470	COG0564	pseudouridine synthase activity
HME7025_RS11475	COG1959	2 iron, 2 sulfur cluster binding
HME7025_RS11480	COG0049	tRNA binding
HME7025_RS11485	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HME7025_RS11490	COG1312	Catalyzes the dehydration of D-mannonate
HME7025_RS11500	COG0514	ATP-dependent DNA helicase (RecQ)
HME7025_RS11505	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HME7025_RS11515	COG0750	zinc metalloprotease
HME7025_RS11520	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HME7025_RS11535	COG0649	NAD binding
HME7025_RS11540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HME7025_RS11550	COG0552	protein localization to endoplasmic reticulum
HME7025_RS11570	COG1160	GTP binding
HME7025_RS11575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HME7025_RS11595	COG1960	acyl-CoA dehydrogenase activity
HME7025_RS11610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HME7025_RS11615	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HME7025_RS11625	COG0051	transcription antitermination factor activity, RNA binding
HME7025_RS11635	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HME7025_RS11640	COG0594	ribonuclease P activity
HME7025_RS11645	COG0793	Belongs to the peptidase S41A family
HME7025_RS11650	COG1214	PFAM Peptidase M22, glycoprotease
HME7025_RS11665	COG3001	Fructosamine kinase
HME7025_RS11670	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HME7025_RS11685	COG0708	Exodeoxyribonuclease III
HME7025_RS11705	COG2176	DNA-directed DNA polymerase activity
HME7025_RS11710	COG0713	ATP synthesis coupled electron transport
HME7025_RS11715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HME7025_RS11720	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HME7025_RS11725	COG1007	ATP synthesis coupled electron transport
HME7025_RS11770	COG0215	cysteine-tRNA ligase activity
HME7025_RS11785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HME7025_RS11790	COG1217	gtp-binding protein TYPA
HME7025_RS11795	COG2333	competence protein COMEC
HME7025_RS11795	COG0658	competence protein
HME7025_RS11800	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HME7025_RS11805	COG0194	GDP metabolic process
HME7025_RS11815	COG1595	DNA-templated transcription, initiation
HME7025_RS11830	COG1077	Cell shape determining protein MreB Mrl
HME7025_RS11840	COG1187	pseudouridine synthase activity
HME7025_RS11860	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HME7025_RS11865	COG1404	Belongs to the peptidase S8 family
HME7025_RS11870	COG0604	alcohol dehydrogenase
HME7025_RS11880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HME7025_RS11895	COG0659	secondary active sulfate transmembrane transporter activity
HME7025_RS11900	COG0288	reversible hydration of carbon dioxide
HME7025_RS11905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HME7025_RS11935	COG1774	PSP1 C-terminal conserved region
HME7025_RS11950	COG1566	PFAM secretion protein HlyD family protein
HME7025_RS11960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HME7025_RS11965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HME7025_RS11965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HME7025_RS11980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HME7025_RS11985	COG2264	protein methyltransferase activity
HME7025_RS11995	COG0860	N-Acetylmuramoyl-L-alanine amidase
HME7025_RS12025	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HME7025_RS12050	COG0505	Belongs to the CarA family
HME7025_RS12055	COG0203	ribosomal protein L17
HME7025_RS12060	COG0202	RNA polymerase activity
HME7025_RS12065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HME7025_RS12070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HME7025_RS12075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HME7025_RS12080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HME7025_RS12085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HME7025_RS12090	COG0024	Methionine aminopeptidase
HME7025_RS12095	COG0201	protein transport
HME7025_RS12100	COG0200	Binds to the 23S rRNA
HME7025_RS12105	COG1841	ribosomal large subunit assembly
HME7025_RS12110	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HME7025_RS12115	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HME7025_RS12120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HME7025_RS12125	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HME7025_RS12130	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HME7025_RS12135	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HME7025_RS12140	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HME7025_RS12145	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HME7025_RS12150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HME7025_RS12155	COG0255	Belongs to the universal ribosomal protein uL29 family
HME7025_RS12160	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HME7025_RS12165	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HME7025_RS12170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HME7025_RS12175	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HME7025_RS12180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HME7025_RS12185	COG0089	rRNA binding
HME7025_RS12190	COG0088	Forms part of the polypeptide exit tunnel
HME7025_RS12195	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HME7025_RS12210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HME7025_RS12210	COG1648	precorrin-2 dehydrogenase activity
HME7025_RS12215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HME7025_RS12220	COG1610	YqeY-like protein
HME7025_RS12230	COG0584	glycerophosphoryl diester phosphodiesterase
HME7025_RS12250	COG2304	oxidoreductase activity
HME7025_RS12255	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HME7025_RS12275	COG0586	Pfam SNARE associated Golgi protein
HME7025_RS12280	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HME7025_RS12290	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HME7025_RS12295	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HME7025_RS12300	COG1045	serine acetyltransferase
HME7025_RS12320	COG1228	amidohydrolase
HME7025_RS12325	COG1228	amidohydrolase
HME7025_RS12350	COG4206	TonB-dependent receptor
HME7025_RS12370	COG1137	ATPase activity
HME7025_RS12375	COG0626	cystathionine gamma-synthase activity
HME7025_RS12410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HME7025_RS12430	COG0673	inositol 2-dehydrogenase activity
HME7025_RS12435	COG0367	asparagine synthase
HME7025_RS12440	COG0438	transferase activity, transferring glycosyl groups
HME7025_RS12440	COG0297	glycogen (starch) synthase activity
HME7025_RS12445	COG0367	asparagine synthase
HME7025_RS12455	COG0500	methyltransferase
HME7025_RS12475	COG0110	maltose O-acetyltransferase activity
HME7025_RS12490	COG0107	imidazoleglycerol-phosphate synthase activity
HME7025_RS12495	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HME7025_RS12505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HME7025_RS12505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HME7025_RS12515	COG0107	imidazoleglycerol-phosphate synthase activity
HME7025_RS12545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HME7025_RS12550	COG1086	Polysaccharide biosynthesis protein
HME7025_RS12560	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HME7025_RS12575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HME7025_RS12580	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HME7025_RS12580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HME7025_RS12625	COG0702	epimerase
HME7025_RS12630	COG4771	TonB-dependent receptor
HME7025_RS12645	COG1741	Belongs to the pirin family
HME7025_RS12650	COG2353	YceI-like domain
HME7025_RS12680	COG1611	Belongs to the LOG family
HME7025_RS12710	COG3119	arylsulfatase activity
HME7025_RS12720	COG3250	beta-galactosidase activity
HME7025_RS12735	COG0363	glucosamine-6-phosphate deaminase activity
HME7025_RS12755	COG1741	Belongs to the pirin family
HME7025_RS12760	COG4771	TonB-dependent receptor
HME7025_RS12790	COG2226	methyltransferase
HME7025_RS12835	COG2271	Major facilitator Superfamily
HME7025_RS12840	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_RS12845	COG1312	Catalyzes the dehydration of D-mannonate
HME7025_RS12850	COG1609	Transcriptional regulator
HME7025_RS12865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HME7025_RS12880	COG2855	membrane
HME7025_RS12970	COG3250	beta-galactosidase activity
HME7025_RS12985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HME7025_RS12990	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HME7025_RS13000	COG0673	inositol 2-dehydrogenase activity
HME7025_RS13010	COG1764	response to oxidative stress
HME7025_RS13040	COG2272	Belongs to the type-B carboxylesterase lipase family
HME7025_RS13070	COG0697	spore germination
HME7025_RS13075	COG2814	Major facilitator Superfamily
HME7025_RS13085	COG1132	(ABC) transporter
HME7025_RS13100	COG3655	Transcriptional regulator
HME7025_RS13185	COG3693	PFAM glycoside hydrolase, family 10
HME7025_RS13185	COG2382	esterase
HME7025_RS13215	COG2755	lipolytic protein G-D-S-L family
HME7025_RS13215	COG0657	acetylesterase activity
HME7025_RS13230	COG0656	L-ascorbic acid biosynthetic process
HME7025_RS13255	COG1733	regulation of RNA biosynthetic process
HME7025_RS13290	COG0318	PFAM AMP-dependent synthetase and ligase
HME7025_RS13305	COG0583	DNA-binding transcription factor activity
HME7025_RS13315	COG0673	inositol 2-dehydrogenase activity
HME7025_RS13320	COG0823	Involved in the tonB-independent uptake of proteins