locus-tag	class	description
D5400_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D5400_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D5400_RS00030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D5400_RS00035	COG0756	dUTP diphosphatase activity
D5400_RS00060	COG2171	N-acyltransferase activity
D5400_RS00070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5400_RS00080	COG0431	NADPH-dependent FMN reductase
D5400_RS00115	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D5400_RS00125	COG0180	Tryptophanyl-tRNA synthetase
D5400_RS00140	COG1957	nucleoside hydrolase
D5400_RS00145	COG0071	Belongs to the small heat shock protein (HSP20) family
D5400_RS00155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5400_RS00160	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D5400_RS00170	COG1137	ATPase activity
D5400_RS00175	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D5400_RS00185	COG0616	signal peptide processing
D5400_RS00190	COG0776	regulation of translation
D5400_RS00215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5400_RS00220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D5400_RS00225	COG0604	alcohol dehydrogenase
D5400_RS00250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5400_RS00255	COG1702	phosphate starvation-inducible protein PhoH
D5400_RS00260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D5400_RS00265	COG4535	Mg2 and Co2 transporter CorC
D5400_RS00270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D5400_RS00275	COG1396	sequence-specific DNA binding
D5400_RS00280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D5400_RS00285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D5400_RS00290	COG0837	glucose binding
D5400_RS00295	COG1803	Methylglyoxal synthase
D5400_RS00300	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D5400_RS00335	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D5400_RS00340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D5400_RS00345	COG0280	phosphate acetyltransferase
D5400_RS00345	COG0281	malic enzyme
D5400_RS00350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D5400_RS00355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D5400_RS00365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5400_RS00370	COG0101	tRNA pseudouridine synthase activity
D5400_RS00375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D5400_RS00380	COG0242	peptide deformylase activity
D5400_RS00390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5400_RS00395	COG1181	Belongs to the D-alanine--D-alanine ligase family
D5400_RS00405	COG1420	regulation of RNA biosynthetic process
D5400_RS00410	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D5400_RS00420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D5400_RS00425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D5400_RS00430	COG3265	gluconokinase activity
D5400_RS00435	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D5400_RS00440	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D5400_RS00475	COG4964	Belongs to the GSP D family
D5400_RS00510	COG2942	2-epimerase
D5400_RS00515	COG4702	Belongs to the UPF0303 family
D5400_RS00520	COG1940	carbohydrate kinase activity
D5400_RS00525	COG3842	ATPase activity
D5400_RS00530	COG0395	ABC-type sugar transport system, permease component
D5400_RS00535	COG1175	transmembrane transport
D5400_RS00540	COG1653	transport
D5400_RS00545	COG1609	Transcriptional regulator
D5400_RS00555	COG0729	surface antigen
D5400_RS00595	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D5400_RS00605	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_RS00615	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D5400_RS00625	COG1643	Atp-dependent helicase
D5400_RS00630	COG4136	ATPase activity
D5400_RS00635	COG4135	transport system, permease component
D5400_RS00640	COG4134	Bacterial extracellular solute-binding protein
D5400_RS00645	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D5400_RS00650	COG0706	membrane insertase activity
D5400_RS00655	COG0594	ribonuclease P activity
D5400_RS00660	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D5400_RS00675	COG4191	Histidine kinase
D5400_RS00745	COG0629	single-stranded DNA binding
D5400_RS00835	COG4959	Type IV secretory pathway protease TraF
D5400_RS00845	COG1196	nuclear chromosome segregation
D5400_RS00845	COG0741	lytic transglycosylase activity
D5400_RS00845	COG0739	heme binding
D5400_RS00865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D5400_RS00875	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D5400_RS00880	COG0785	Cytochrome C biogenesis protein
D5400_RS00890	COG1914	H( )-stimulated, divalent metal cation uptake system
D5400_RS00900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D5400_RS00905	COG2072	flavoprotein involved in K transport
D5400_RS00910	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_RS00915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5400_RS00925	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_RS00925	COG1388	LysM domain
D5400_RS00935	COG3034	peptidoglycan biosynthetic process
D5400_RS00970	COG2217	Heavy metal translocating P-type atpase
D5400_RS00980	COG1999	signal sequence binding
D5400_RS00995	COG1230	cation diffusion facilitator family transporter
D5400_RS01005	COG0745	RESPONSE REGULATOR receiver
D5400_RS01015	COG0789	Transcriptional regulator
D5400_RS01025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D5400_RS01030	COG0741	lytic transglycosylase activity
D5400_RS01030	COG1196	nuclear chromosome segregation
D5400_RS01030	COG0739	heme binding
D5400_RS01045	COG1138	Cytochrome C-type biogenesis protein
D5400_RS01050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5400_RS01060	COG0583	DNA-binding transcription factor activity
D5400_RS01065	COG4962	Type ii secretion system protein e
D5400_RS01080	COG3451	type IV secretory pathway VirB4
D5400_RS01095	COG3846	protein secretion by the type IV secretion system
D5400_RS01110	COG2948	multi-organism process
D5400_RS01130	COG0464	growth
D5400_RS01165	COG0583	DNA-binding transcription factor activity
D5400_RS01170	COG2855	membrane
D5400_RS01175	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5400_RS01190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D5400_RS01210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5400_RS01220	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D5400_RS01225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5400_RS01245	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D5400_RS01250	COG0443	Heat shock 70 kDa protein
D5400_RS01255	COG0484	heat shock protein binding
D5400_RS01260	COG3963	phosphatidate phosphatase activity
D5400_RS01270	COG0284	orotidine-5'-phosphate decarboxylase activity
D5400_RS01285	COG1968	undecaprenyl-diphosphatase activity
D5400_RS01295	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D5400_RS01305	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D5400_RS01310	COG0840	transmembrane signaling receptor activity
D5400_RS01320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5400_RS01330	COG0747	negative chemotaxis
D5400_RS01335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5400_RS01350	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D5400_RS01355	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D5400_RS01375	COG2816	NAD+ diphosphatase activity
D5400_RS01385	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D5400_RS01390	COG3474	cytochrome
D5400_RS01395	COG4166	transmembrane transport
D5400_RS01405	COG4174	ABC transporter (Permease)
D5400_RS01410	COG4239	(ABC) transporter, permease
D5400_RS01425	COG4172	Belongs to the ABC transporter superfamily
D5400_RS01430	COG1051	belongs to the nudix hydrolase family
D5400_RS01435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5400_RS01455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D5400_RS01465	COG0481	GTPase activity
D5400_RS01475	COG3239	Fatty acid desaturase
D5400_RS01490	COG0765	amino acid transport
D5400_RS01495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5400_RS01500	COG1802	Transcriptional regulator
D5400_RS01505	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS01530	COG0697	spore germination
D5400_RS01540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5400_RS01540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5400_RS01555	COG1115	amino acid carrier protein
D5400_RS01585	COG1185	polyribonucleotide nucleotidyltransferase activity
D5400_RS01590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D5400_RS01595	COG3920	Histidine kinase
D5400_RS01600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D5400_RS01605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D5400_RS01610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D5400_RS01625	COG0779	Required for maturation of 30S ribosomal subunits
D5400_RS01630	COG1132	(ABC) transporter
D5400_RS01635	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D5400_RS01640	COG2900	Belongs to the SlyX family
D5400_RS01650	COG3845	ABC transporter
D5400_RS01655	COG1079	Belongs to the binding-protein-dependent transport system permease family
D5400_RS01660	COG1079	Belongs to the binding-protein-dependent transport system permease family
D5400_RS01675	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D5400_RS01680	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D5400_RS01690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D5400_RS01700	COG1012	belongs to the aldehyde dehydrogenase family
D5400_RS01705	COG0174	glutamine synthetase
D5400_RS01735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D5400_RS01740	COG0792	nuclease activity
D5400_RS01745	COG0189	ligase activity
D5400_RS01750	COG0606	chelatase, subunit chli
D5400_RS01760	COG3186	Phenylalanine-4-hydroxylase
D5400_RS01765	COG1522	sequence-specific DNA binding
D5400_RS01770	COG1294	oxidase, subunit
D5400_RS01775	COG1271	oxidase subunit
D5400_RS01805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D5400_RS01815	COG1902	pentaerythritol trinitrate reductase activity
D5400_RS01825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D5400_RS01835	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D5400_RS01855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5400_RS01855	COG0072	phenylalanine-tRNA ligase activity
D5400_RS01865	COG1744	ABC transporter substrate-binding protein PnrA-like
D5400_RS01870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5400_RS01890	COG0405	Gamma-glutamyltransferase
D5400_RS01900	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D5400_RS01915	COG0601	transmembrane transport
D5400_RS01920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5400_RS01925	COG0444	Belongs to the ABC transporter superfamily
D5400_RS01935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D5400_RS01945	COG2197	response regulator
D5400_RS01950	COG3916	Acyl-homoserine-lactone synthase
D5400_RS01965	COG1272	protein, Hemolysin III
D5400_RS01970	COG2186	Transcriptional regulator
D5400_RS01980	COG0473	3-isopropylmalate dehydrogenase activity
D5400_RS01990	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS02025	COG0596	Alpha beta hydrolase
D5400_RS02030	COG4948	Mandelate Racemase Muconate Lactonizing
D5400_RS02055	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS02060	COG3180	Ammonia monooxygenase
D5400_RS02065	COG4948	Mandelate Racemase Muconate Lactonizing
D5400_RS02090	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D5400_RS02100	COG1960	acyl-CoA dehydrogenase activity
D5400_RS02105	COG2079	MmgE PrpD family protein
D5400_RS02115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5400_RS02125	COG0539	negative regulation of cytoplasmic translation
D5400_RS02130	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D5400_RS02135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D5400_RS02155	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS02160	COG2186	Transcriptional regulator
D5400_RS02170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_RS02175	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D5400_RS02180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_RS02190	COG0730	response to heat
D5400_RS02195	COG0671	phosphoesterase, PA-phosphatase related
D5400_RS02200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D5400_RS02210	COG0251	oxidation-reduction process
D5400_RS02235	COG1904	glucuronate isomerase
D5400_RS02240	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_RS02245	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D5400_RS02250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_RS02255	COG2942	2-epimerase
D5400_RS02260	COG1802	Transcriptional regulator
D5400_RS02265	COG1312	Catalyzes the dehydration of D-mannonate
D5400_RS02270	COG0246	Mannitol dehydrogenase
D5400_RS02275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5400_RS02280	COG0583	DNA-binding transcription factor activity
D5400_RS02285	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D5400_RS02290	COG2388	GCN5-related N-acetyl-transferase
D5400_RS02295	COG1741	Belongs to the pirin family
D5400_RS02310	COG3842	ATPase activity
D5400_RS02315	COG0395	ABC-type sugar transport system, permease component
D5400_RS02320	COG1175	transmembrane transport
D5400_RS02335	COG1177	transmembrane transport
D5400_RS02340	COG3842	ATPase activity
D5400_RS02345	COG0583	DNA-binding transcription factor activity
D5400_RS02350	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS02385	COG0133	tryptophan synthase activity
D5400_RS02390	COG0159	tryptophan synthase activity
D5400_RS02395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D5400_RS02400	COG0285	dihydrofolate synthase activity
D5400_RS02410	COG1074	ATP-dependent DNA helicase activity
D5400_RS02415	COG2887	Belongs to the helicase family. UvrD subfamily
D5400_RS02420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D5400_RS02425	COG3178	'Phosphotransferase
D5400_RS02430	COG2205	protein histidine kinase activity
D5400_RS02435	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D5400_RS02445	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5400_RS02445	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5400_RS02455	COG2205	protein histidine kinase activity
D5400_RS02460	COG0745	RESPONSE REGULATOR receiver
D5400_RS02465	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D5400_RS02485	COG1072	(Pantothenic acid kinase))
D5400_RS02490	COG0140	phosphoribosyl-ATP diphosphatase activity
D5400_RS02495	COG0107	imidazoleglycerol-phosphate synthase activity
D5400_RS02500	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D5400_RS02505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D5400_RS02515	COG0131	Imidazoleglycerol-phosphate dehydratase
D5400_RS02520	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D5400_RS02525	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D5400_RS02555	COG3030	protein affecting phage T7 exclusion by the F plasmid
D5400_RS02560	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D5400_RS02565	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5400_RS02570	COG0237	dephospho-CoA kinase activity
D5400_RS02575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D5400_RS02580	COG0424	maF-like protein
D5400_RS02585	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D5400_RS02590	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D5400_RS02595	COG1981	membrane
D5400_RS02600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D5400_RS02605	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D5400_RS02610	COG0445	tRNA wobble uridine modification
D5400_RS02615	COG0357	Ribosomal RNA small subunit methyltransferase G
D5400_RS02640	COG0495	leucyl-tRNA aminoacylation
D5400_RS02645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D5400_RS02665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D5400_RS02665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D5400_RS02670	COG0501	Belongs to the peptidase M48B family
D5400_RS02690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5400_RS02710	COG2902	Dehydrogenase
D5400_RS02730	COG0288	reversible hydration of carbon dioxide
D5400_RS02740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D5400_RS02745	COG3214	Protein conserved in bacteria
D5400_RS02750	COG0473	3-isopropylmalate dehydrogenase activity
D5400_RS02755	COG0004	ammonium transporteR
D5400_RS02760	COG0347	Belongs to the P(II) protein family
D5400_RS02765	COG1946	Acyl-CoA thioesterase
D5400_RS02770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5400_RS02775	COG2835	tetraacyldisaccharide 4'-kinase activity
D5400_RS02780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D5400_RS02800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5400_RS02800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5400_RS02805	COG0509	glycine decarboxylation via glycine cleavage system
D5400_RS02810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D5400_RS02815	COG0840	transmembrane signaling receptor activity
D5400_RS02850	COG0066	3-isopropylmalate dehydratase activity
D5400_RS02860	COG1674	ftsk spoiiie
D5400_RS02865	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D5400_RS02875	COG3932	Exopolysaccharide synthesis, ExoD
D5400_RS02890	COG0745	RESPONSE REGULATOR receiver
D5400_RS02900	COG2264	protein methyltransferase activity
D5400_RS02915	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D5400_RS02920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D5400_RS02925	COG0181	hydroxymethylbilane synthase activity
D5400_RS02950	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D5400_RS02960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D5400_RS02965	COG1247	-acetyltransferase
D5400_RS02970	COG1217	gtp-binding protein TYPA
D5400_RS02975	COG0339	signal peptide processing
D5400_RS02985	COG2814	Major facilitator Superfamily
D5400_RS02990	COG0137	argininosuccinate synthase activity
D5400_RS03005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D5400_RS03015	COG1595	DNA-templated transcription, initiation
D5400_RS03025	COG2154	pterin-4-alpha-carbinolamine dehydratase
D5400_RS03030	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D5400_RS03040	COG4181	ATPase activity
D5400_RS03045	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D5400_RS03050	COG0670	Belongs to the BI1 family
D5400_RS03070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D5400_RS03075	COG4133	protoheme IX ABC transporter activity
D5400_RS03080	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5400_RS03085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5400_RS03095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5400_RS03105	COG3609	addiction module antidote protein, CC2985 family
D5400_RS03110	COG2917	probably involved in intracellular septation
D5400_RS03115	COG0552	protein localization to endoplasmic reticulum
D5400_RS03120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5400_RS03125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D5400_RS03140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D5400_RS03145	COG1605	Chorismate mutase
D5400_RS03145	COG0287	Prephenate dehydrogenase
D5400_RS03150	COG0228	four-way junction DNA binding
D5400_RS03155	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D5400_RS03160	COG0336	Belongs to the RNA methyltransferase TrmD family
D5400_RS03165	COG0335	large ribosomal subunit rRNA binding
D5400_RS03175	COG0765	amino acid transport
D5400_RS03180	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D5400_RS03185	COG3706	GGDEF domain
D5400_RS03230	COG1764	response to oxidative stress
D5400_RS03235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5400_RS03240	COG2845	Protein of unknown function (DUF459)
D5400_RS03245	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D5400_RS03250	COG0039	L-malate dehydrogenase activity
D5400_RS03255	COG0045	succinate-CoA ligase (ADP-forming) activity
D5400_RS03265	COG0567	Dehydrogenase, E1 component
D5400_RS03270	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5400_RS03275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5400_RS03295	COG4974	Belongs to the 'phage' integrase family
D5400_RS03350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D5400_RS03355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D5400_RS03370	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5400_RS03375	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D5400_RS03380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D5400_RS03385	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D5400_RS03390	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D5400_RS03405	COG0793	Belongs to the peptidase S41A family
D5400_RS03420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D5400_RS03425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D5400_RS03430	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D5400_RS03435	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D5400_RS03440	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D5400_RS03445	COG0799	negative regulation of ribosome biogenesis
D5400_RS03460	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D5400_RS03465	COG3743	rRNA binding
D5400_RS03465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D5400_RS03505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_RS03515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_RS03530	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS03560	COG0835	chemotaxis
D5400_RS03565	COG0840	transmembrane signaling receptor activity
D5400_RS03570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5400_RS03575	COG4608	Belongs to the ABC transporter superfamily
D5400_RS03580	COG0444	Belongs to the ABC transporter superfamily
D5400_RS03585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5400_RS03595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5400_RS03610	COG0436	Aminotransferase
D5400_RS03630	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_RS03675	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_RS03685	COG0235	Class ii aldolase
D5400_RS03690	COG0583	DNA-binding transcription factor activity
D5400_RS03695	COG0028	Belongs to the TPP enzyme family
D5400_RS03730	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS03740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D5400_RS03745	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5400_RS03745	COG0022	dehydrogenase e1 component
D5400_RS03750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D5400_RS03755	COG0022	dehydrogenase e1 component
D5400_RS03765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D5400_RS03820	COG0438	transferase activity, transferring glycosyl groups
D5400_RS03830	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D5400_RS03845	COG0596	Alpha beta hydrolase
D5400_RS03860	COG0346	lactoylglutathione lyase activity
D5400_RS03870	COG1295	ribonuclease BN
D5400_RS03875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5400_RS03875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5400_RS03880	COG3842	ATPase activity
D5400_RS03980	COG0535	radical SAM domain protein
D5400_RS03985	COG0535	radical SAM domain protein
D5400_RS03990	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
D5400_RS03995	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D5400_RS04040	COG1131	(ABC) transporter
D5400_RS04050	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D5400_RS04055	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D5400_RS04090	COG2202	Pas domain
D5400_RS04090	COG2205	protein histidine kinase activity
D5400_RS04100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D5400_RS04105	COG0583	DNA-binding transcription factor activity
D5400_RS04125	COG4993	Dehydrogenase
D5400_RS04140	COG0024	Methionine aminopeptidase
D5400_RS04145	COG0583	DNA-binding transcription factor activity
D5400_RS04165	COG0473	3-isopropylmalate dehydrogenase activity
D5400_RS04170	COG1053	succinate dehydrogenase
D5400_RS04205	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D5400_RS04210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5400_RS04215	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D5400_RS04235	COG2081	HI0933 family
D5400_RS04245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5400_RS04265	COG0395	ABC-type sugar transport system, permease component
D5400_RS04290	COG2390	Transcriptional regulator
D5400_RS04300	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D5400_RS04305	COG3639	organic phosphonate transmembrane transporter activity
D5400_RS04315	COG2188	Transcriptional regulator
D5400_RS04345	COG1063	alcohol dehydrogenase
D5400_RS04355	COG3284	Transcriptional regulator
D5400_RS04365	COG1960	acyl-CoA dehydrogenase activity
D5400_RS04370	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D5400_RS04380	COG2217	Heavy metal translocating P-type atpase
D5400_RS04435	COG2094	Belongs to the DNA glycosylase MPG family
D5400_RS04495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_RS04500	COG0402	S-adenosylhomocysteine deaminase activity
D5400_RS04510	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5400_RS04520	COG0488	(ABC) transporter
D5400_RS04540	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D5400_RS04550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D5400_RS04555	COG1329	Transcriptional regulator
D5400_RS04595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D5400_RS04600	COG0784	Response regulator, receiver
D5400_RS04600	COG2205	protein histidine kinase activity
D5400_RS04600	COG5002	protein histidine kinase activity
D5400_RS04605	COG0142	geranyltranstransferase activity
D5400_RS04610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5400_RS04615	COG0625	glutathione transferase activity
D5400_RS04620	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D5400_RS04670	COG2223	nitrite transmembrane transporter activity
D5400_RS04675	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D5400_RS04685	COG0693	protein deglycase activity
D5400_RS04725	COG0438	transferase activity, transferring glycosyl groups
D5400_RS04745	COG3459	Glycosyltransferase 36 associated
D5400_RS04785	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D5400_RS04790	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D5400_RS04795	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
D5400_RS04800	COG1063	alcohol dehydrogenase
D5400_RS04805	COG0500	methyltransferase
D5400_RS04810	COG0142	geranyltranstransferase activity
D5400_RS04825	COG1562	ergosterol biosynthetic process
D5400_RS04830	COG1233	COG1233 Phytoene dehydrogenase and related
D5400_RS04840	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
D5400_RS04850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D5400_RS04870	COG1473	amidohydrolase
D5400_RS04875	COG1686	Belongs to the peptidase S11 family
D5400_RS04880	COG0523	cobalamin synthesis protein
D5400_RS04890	COG3034	peptidoglycan biosynthetic process
D5400_RS04895	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D5400_RS04900	COG0156	8-amino-7-oxononanoate synthase activity
D5400_RS04925	COG0784	Response regulator, receiver
D5400_RS04925	COG5002	protein histidine kinase activity
D5400_RS04935	COG1132	(ABC) transporter
D5400_RS04945	COG0156	8-amino-7-oxononanoate synthase activity
D5400_RS04955	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D5400_RS04990	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
D5400_RS04995	COG1429	ligase activity, forming nitrogen-metal bonds
D5400_RS05005	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D5400_RS05025	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D5400_RS05030	COG2211	Major facilitator Superfamily
D5400_RS05035	COG0644	oxidoreductase
D5400_RS05045	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D5400_RS05060	COG0456	acetyltransferase
D5400_RS05065	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D5400_RS05070	COG1917	Cupin 2, conserved barrel domain protein
D5400_RS05075	COG0527	aspartate kinase activity
D5400_RS05105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D5400_RS05110	COG2423	ornithine cyclodeaminase activity
D5400_RS05115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D5400_RS05120	COG0006	proline dipeptidase activity
D5400_RS05140	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS05145	COG0418	dihydroorotase activity
D5400_RS05150	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D5400_RS05170	COG0166	Belongs to the GPI family
D5400_RS05185	COG0318	PFAM AMP-dependent synthetase and ligase
D5400_RS05200	COG0587	DNA-directed DNA polymerase activity
D5400_RS05240	COG2326	polyphosphate kinase activity
D5400_RS05245	COG5002	protein histidine kinase activity
D5400_RS05255	COG0573	inorganic phosphate transmembrane transporter activity
D5400_RS05265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D5400_RS05270	COG0704	Plays a role in the regulation of phosphate uptake
D5400_RS05275	COG0745	RESPONSE REGULATOR receiver
D5400_RS05285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D5400_RS05290	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D5400_RS05305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5400_RS05310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5400_RS05315	COG2967	ApaG domain
D5400_RS05330	COG0717	Belongs to the dCTP deaminase family
D5400_RS05390	COG1024	Enoyl-CoA hydratase
D5400_RS05390	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5400_RS05395	COG0183	Belongs to the thiolase family
D5400_RS05400	COG1960	acyl-CoA dehydrogenase activity
D5400_RS05405	COG1960	acyl-CoA dehydrogenase activity
D5400_RS05420	COG0730	response to heat
D5400_RS05435	COG1201	RNA secondary structure unwinding
D5400_RS05440	COG2226	methyltransferase
D5400_RS05455	COG1793	dna ligase
D5400_RS05475	COG0123	including yeast histone deacetylase and acetoin utilization protein
D5400_RS05480	COG0534	Mate efflux family protein
D5400_RS05485	COG0167	dihydroorotate dehydrogenase activity
D5400_RS05515	COG2205	protein histidine kinase activity
D5400_RS05515	COG0784	Response regulator, receiver
D5400_RS05515	COG2198	Histidine kinase
D5400_RS05520	COG1970	mechanosensitive ion channel activity
D5400_RS05540	COG2897	thiosulfate sulfurtransferase activity
D5400_RS05545	COG2391	methyltransferase activity
D5400_RS05560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5400_RS05580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D5400_RS05590	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D5400_RS05595	COG5328	Belongs to the UPF0262 family
D5400_RS05605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D5400_RS05610	COG0424	maF-like protein
D5400_RS05615	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D5400_RS05645	COG0840	transmembrane signaling receptor activity
D5400_RS05655	COG0745	RESPONSE REGULATOR receiver
D5400_RS05660	COG0643	Histidine kinase
D5400_RS05660	COG2198	Histidine kinase
D5400_RS05665	COG0835	chemotaxis
D5400_RS05670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D5400_RS05675	COG2201	protein-glutamate methylesterase activity
D5400_RS05680	COG0745	RESPONSE REGULATOR receiver
D5400_RS05685	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D5400_RS05695	COG1766	The M ring may be actively involved in energy transduction
D5400_RS05720	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5400_RS05725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5400_RS05730	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5400_RS05735	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5400_RS05740	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D5400_RS05750	COG4786	Flagellar basal body rod
D5400_RS05755	COG1157	protein secretion by the type III secretion system
D5400_RS05765	COG1815	bacterial-type flagellum-dependent cell motility
D5400_RS05770	COG1558	bacterial-type flagellum-dependent cell motility
D5400_RS05775	COG1677	Flagellar hook-basal body complex protein FliE
D5400_RS05780	COG4786	Flagellar basal body rod
D5400_RS05785	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
D5400_RS05790	COG1706	bacterial-type flagellum-dependent cell motility
D5400_RS05800	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D5400_RS05810	COG1338	Plays a role in the flagellum-specific transport system
D5400_RS05815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5400_RS05820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5400_RS05830	COG2089	acid synthase
D5400_RS05845	COG1083	cytidylyl-transferase
D5400_RS05850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5400_RS05855	COG1086	Polysaccharide biosynthesis protein
D5400_RS05890	COG1749	Flagellar hook protein flgE
D5400_RS05910	COG5443	negative regulation of bacterial-type flagellum assembly
D5400_RS05915	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D5400_RS05920	COG4794	Type iii secretion
D5400_RS05925	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5400_RS05955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D5400_RS05960	COG1609	Transcriptional regulator
D5400_RS05965	COG1653	transport
D5400_RS05970	COG1175	transmembrane transport
D5400_RS05975	COG0395	ABC-type sugar transport system, permease component
D5400_RS05980	COG0366	Alpha amylase catalytic
D5400_RS05985	COG3842	ATPase activity
D5400_RS05990	COG0129	dihydroxy-acid dehydratase activity
D5400_RS05995	COG0363	glucosamine-6-phosphate deaminase activity
D5400_RS06000	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D5400_RS06005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5400_RS06010	COG0174	glutamine synthetase
D5400_RS06025	COG0840	transmembrane signaling receptor activity
D5400_RS06030	COG0671	phosphoesterase, PA-phosphatase related
D5400_RS06050	COG2224	Isocitrate lyase
D5400_RS06055	COG3800	Transcriptional regulator
D5400_RS06055	COG1396	sequence-specific DNA binding
D5400_RS06065	COG3842	ATPase activity
D5400_RS06070	COG1176	ABC-type spermidine putrescine transport system, permease component I
D5400_RS06075	COG1177	transmembrane transport
D5400_RS06085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5400_RS06090	COG2205	protein histidine kinase activity
D5400_RS06115	COG0483	inositol monophosphate 1-phosphatase activity
D5400_RS06120	COG2089	acid synthase
D5400_RS06185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D5400_RS06200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5400_RS06200	COG2111	Na H antiporter
D5400_RS06205	COG2111	Na H antiporter
D5400_RS06210	COG1006	Multisubunit Na H antiporter MnhC subunit
D5400_RS06215	COG0651	ATP synthesis coupled electron transport
D5400_RS06230	COG1320	monovalent cation:proton antiporter activity
D5400_RS06235	COG4191	Histidine kinase
D5400_RS06240	COG2204	response regulator
D5400_RS06245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5400_RS06255	COG4172	Belongs to the ABC transporter superfamily
D5400_RS06260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5400_RS06265	COG0601	transmembrane transport
D5400_RS06270	COG4166	transmembrane transport
D5400_RS06280	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D5400_RS06295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D5400_RS06295	COG0475	glutathione-regulated potassium exporter activity
D5400_RS06300	COG2084	Dehydrogenase
D5400_RS06310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D5400_RS06310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D5400_RS06315	COG3769	mannosylglycerate metabolic process
D5400_RS06320	COG1215	transferase activity, transferring glycosyl groups
D5400_RS06325	COG0366	Alpha amylase catalytic
D5400_RS06360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5400_RS06360	COG3453	Protein conserved in bacteria
D5400_RS06385	COG0559	Belongs to the binding-protein-dependent transport system permease family
D5400_RS06395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5400_RS06435	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D5400_RS06440	COG1024	Enoyl-CoA hydratase
D5400_RS06445	COG1024	Enoyl-CoA hydratase
D5400_RS06445	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5400_RS06460	COG0625	glutathione transferase activity
D5400_RS06490	COG3416	Protein conserved in bacteria
D5400_RS06505	COG3909	cytochrome
D5400_RS06510	COG2197	response regulator
D5400_RS06515	COG4585	Histidine kinase
D5400_RS06525	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
D5400_RS06535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5400_RS06595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5400_RS06600	COG1450	Type ii and iii secretion system protein
D5400_RS06610	COG4585	Histidine kinase
D5400_RS06615	COG2197	response regulator
D5400_RS06625	COG0420	3'-5' exonuclease activity
D5400_RS06630	COG4717	serine-type aminopeptidase activity
D5400_RS06635	COG3920	Histidine kinase
D5400_RS06640	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS06655	COG1017	nitric oxide dioxygenase activity
D5400_RS06655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D5400_RS06665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D5400_RS06670	COG2010	Cytochrome c
D5400_RS06670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D5400_RS06690	COG0753	catalase activity
D5400_RS06695	COG1309	transcriptional regulator
D5400_RS06700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5400_RS06710	COG0783	Belongs to the Dps family
D5400_RS06715	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D5400_RS06725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_RS06735	COG1802	Transcriptional regulator
D5400_RS06745	COG0583	DNA-binding transcription factor activity
D5400_RS06755	COG1522	sequence-specific DNA binding
D5400_RS06765	COG3800	Transcriptional regulator
D5400_RS06765	COG1396	sequence-specific DNA binding
D5400_RS06770	COG0156	8-amino-7-oxononanoate synthase activity
D5400_RS06775	COG1063	alcohol dehydrogenase
D5400_RS06780	COG2072	flavoprotein involved in K transport
D5400_RS06800	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D5400_RS06810	COG1177	transmembrane transport
D5400_RS06815	COG3842	ATPase activity
D5400_RS06825	COG2391	methyltransferase activity
D5400_RS06845	COG0446	pyridine nucleotide-disulphide oxidoreductase
D5400_RS06865	COG1176	ABC-type spermidine putrescine transport system, permease component I
D5400_RS06870	COG1177	transmembrane transport
D5400_RS06875	COG3842	ATPase activity
D5400_RS06905	COG3443	Belongs to the bacterial solute-binding protein 9 family
D5400_RS06915	COG0252	asparaginase activity
D5400_RS06920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_RS06945	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D5400_RS06945	COG1082	Xylose isomerase domain protein TIM barrel
D5400_RS06950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D5400_RS06955	COG1802	Transcriptional regulator
D5400_RS06960	COG1802	Transcriptional regulator
D5400_RS06965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_RS06975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_RS06980	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D5400_RS06995	COG0129	dihydroxy-acid dehydratase activity
D5400_RS07000	COG4214	carbohydrate transport
D5400_RS07010	COG4213	ABC transporter substrate-binding protein
D5400_RS07015	COG3386	PFAM SMP-30 Gluconolaconase
D5400_RS07020	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5400_RS07025	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5400_RS07030	COG1129	ABC transporter
D5400_RS07035	COG1879	ABC-type sugar transport system periplasmic component
D5400_RS07060	COG2188	Transcriptional regulator
D5400_RS07065	COG3624	Phosphonate C-P lyase system protein PhnG
D5400_RS07070	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
D5400_RS07075	COG3626	phosphonate metabolism
D5400_RS07080	COG3627	carbon phosphorus lyase activity
D5400_RS07085	COG4107	phosphonate C-P lyase system protein PhnK
D5400_RS07090	COG4778	phosphonate C-P lyase system protein PhnL
D5400_RS07100	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
D5400_RS07105	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D5400_RS07110	COG3639	organic phosphonate transmembrane transporter activity
D5400_RS07115	COG3639	organic phosphonate transmembrane transporter activity
D5400_RS07125	COG3698	Phosphodiester glycosidase
D5400_RS07140	COG1162	GTPase activity
D5400_RS07145	COG3706	GGDEF domain
D5400_RS07155	COG0488	(ABC) transporter
D5400_RS07175	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5400_RS07210	COG3300	MHYT domain
D5400_RS07210	COG5001	Diguanylate cyclase
D5400_RS07220	COG0402	S-adenosylhomocysteine deaminase activity
D5400_RS07235	COG1116	anion transmembrane transporter activity
D5400_RS07250	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D5400_RS07255	COG1309	transcriptional regulator
D5400_RS07260	COG0667	Aldo Keto reductase
D5400_RS07275	COG0673	inositol 2-dehydrogenase activity
D5400_RS07305	COG3842	ATPase activity
D5400_RS07310	COG3842	ATPase activity
D5400_RS07315	COG1175	transmembrane transport
D5400_RS07320	COG0395	ABC-type sugar transport system, permease component
D5400_RS07335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D5400_RS07345	COG3300	MHYT domain
D5400_RS07345	COG5001	Diguanylate cyclase
D5400_RS07355	COG0033	Phosphoglucomutase
D5400_RS07360	COG1959	2 iron, 2 sulfur cluster binding
D5400_RS07375	COG1435	thymidine kinase activity
D5400_RS07400	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D5400_RS07415	COG0512	Glutamine amidotransferase of anthranilate synthase
D5400_RS07415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D5400_RS07420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D5400_RS07425	COG1960	acyl-CoA dehydrogenase activity
D5400_RS07430	COG1733	regulation of RNA biosynthetic process
D5400_RS07440	COG4721	ABC-type cobalt transport system, permease component
D5400_RS07445	COG1122	ATPase activity
D5400_RS07480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5400_RS07485	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5400_RS07485	COG0596	Alpha beta hydrolase
D5400_RS07505	COG0435	Glutathione S-transferase
D5400_RS07530	COG0714	Associated with various cellular activities
D5400_RS07545	COG0617	tRNA 3'-terminal CCA addition
D5400_RS07555	COG0408	coproporphyrinogen oxidase activity
D5400_RS07565	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D5400_RS07570	COG1132	(ABC) transporter
D5400_RS07575	COG1132	(ABC) transporter
D5400_RS07590	COG2857	Cytochrome c1
D5400_RS07590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D5400_RS07595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D5400_RS07610	COG0012	GTP binding
D5400_RS07615	COG0193	aminoacyl-tRNA hydrolase activity
D5400_RS07620	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D5400_RS07630	COG0129	dihydroxy-acid dehydratase activity
D5400_RS07635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D5400_RS07650	COG1496	oxidoreductase activity
D5400_RS07660	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D5400_RS07680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5400_RS07690	COG2205	protein histidine kinase activity
D5400_RS07695	COG0745	RESPONSE REGULATOR receiver
D5400_RS07700	COG1846	Transcriptional regulator
D5400_RS07705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5400_RS07715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5400_RS07725	COG1278	Cold shock
D5400_RS07745	COG2200	EAL domain
D5400_RS07750	COG0436	Aminotransferase
D5400_RS07755	COG0583	DNA-binding transcription factor activity
D5400_RS07760	COG0492	ferredoxin-NADP+ reductase activity
D5400_RS07765	COG1522	sequence-specific DNA binding
D5400_RS07770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5400_RS07775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D5400_RS07785	COG2321	neutral zinc metallopeptidase
D5400_RS07795	COG0505	Belongs to the CarA family
D5400_RS07815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D5400_RS07820	COG1309	transcriptional regulator
D5400_RS07830	COG3706	GGDEF domain
D5400_RS07835	COG0432	Pfam Uncharacterised protein family UPF0047
D5400_RS07860	COG2968	Membrane
D5400_RS07875	COG2207	Transcriptional regulator
D5400_RS07880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D5400_RS07915	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D5400_RS07920	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS07935	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
D5400_RS07940	COG4638	Rieske (2fe-2S)
D5400_RS07975	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5400_RS08005	COG2080	2 iron, 2 sulfur cluster binding
D5400_RS08010	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D5400_RS08015	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D5400_RS08030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_RS08045	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D5400_RS08055	COG1732	Glycine betaine
D5400_RS08060	COG1174	glycine betaine transport
D5400_RS08065	COG1125	glycine betaine transport
D5400_RS08070	COG1174	glycine betaine transport
D5400_RS08075	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D5400_RS08080	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
D5400_RS08085	COG3454	Phosphonate metabolism
D5400_RS08095	COG3448	diguanylate cyclase activity
D5400_RS08095	COG4175	Glycine betaine
D5400_RS08110	COG1309	transcriptional regulator
D5400_RS08115	COG3119	arylsulfatase activity
D5400_RS08120	COG1012	belongs to the aldehyde dehydrogenase family
D5400_RS08125	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D5400_RS08130	COG4154	Belongs to the RbsD FucU family
D5400_RS08140	COG0028	Belongs to the TPP enzyme family
D5400_RS08145	COG2267	carboxylic ester hydrolase activity
D5400_RS08180	COG0019	diaminopimelate decarboxylase activity
D5400_RS08200	COG2264	protein methyltransferase activity
D5400_RS08210	COG5001	Diguanylate cyclase
D5400_RS08230	COG3023	N-Acetylmuramoyl-L-alanine amidase
D5400_RS08245	COG2001	Belongs to the MraZ family
D5400_RS08250	COG0275	rRNA processing
D5400_RS08265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D5400_RS08275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5400_RS08280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D5400_RS08290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5400_RS08295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D5400_RS08300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D5400_RS08305	COG1181	Belongs to the D-alanine--D-alanine ligase family
D5400_RS08310	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D5400_RS08315	COG0849	cell division
D5400_RS08320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D5400_RS08330	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D5400_RS08340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D5400_RS08355	COG0006	proline dipeptidase activity
D5400_RS08360	COG2264	protein methyltransferase activity
D5400_RS08365	COG1999	signal sequence binding
D5400_RS08375	COG1012	belongs to the aldehyde dehydrogenase family
D5400_RS08395	COG4957	zinc ion binding
D5400_RS08405	COG0210	DNA helicase
D5400_RS08420	COG1404	Belongs to the peptidase S8 family
D5400_RS08425	COG0412	Dienelactone hydrolase
D5400_RS08435	COG1285	pathogenesis
D5400_RS08445	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D5400_RS08475	COG0277	FAD linked oxidase domain protein
D5400_RS08515	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D5400_RS08525	COG0330	HflC and HflK could
D5400_RS08530	COG0330	HflC and HflK could
D5400_RS08545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5400_RS08550	COG0560	Phosphoserine phosphatase
D5400_RS08550	COG3830	Belongs to the UPF0237 family
D5400_RS08555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D5400_RS08570	COG0028	Belongs to the TPP enzyme family
D5400_RS08575	COG0440	acetolactate synthase activity
D5400_RS08585	COG4423	Transcription factor
D5400_RS08590	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
D5400_RS08595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5400_RS08600	COG3239	Fatty acid desaturase
D5400_RS08605	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D5400_RS08610	COG0859	PFAM glycosyl transferase family 9
D5400_RS08615	COG0859	PFAM glycosyl transferase family 9
D5400_RS08620	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D5400_RS08620	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D5400_RS08630	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D5400_RS08635	COG1846	Transcriptional regulator
D5400_RS08640	COG1764	response to oxidative stress
D5400_RS08645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5400_RS08650	COG0471	metal ion transport
D5400_RS08680	COG0384	phenazine biosynthesis protein PhzF
D5400_RS08710	COG2358	TRAP transporter, solute receptor (TAXI family
D5400_RS08745	COG2323	membrane
D5400_RS08755	COG0659	secondary active sulfate transmembrane transporter activity
D5400_RS08760	COG1819	glycosyl
D5400_RS08780	COG1462	curli production assembly transport component CsgG
D5400_RS08820	COG1960	acyl-CoA dehydrogenase activity
D5400_RS08825	COG0583	DNA-binding transcription factor activity
D5400_RS08845	COG0438	transferase activity, transferring glycosyl groups
D5400_RS08860	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D5400_RS08865	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D5400_RS08875	COG0667	Aldo Keto reductase
D5400_RS08905	COG1960	acyl-CoA dehydrogenase activity
D5400_RS08920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D5400_RS08970	COG0583	DNA-binding transcription factor activity
D5400_RS08975	COG2871	sodium ion transport
D5400_RS08985	COG1410	methionine synthase
D5400_RS08985	COG0646	methionine synthase
D5400_RS08990	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D5400_RS09010	COG5012	cobalamin binding
D5400_RS09015	COG5598	trimethylamine methyltransferase
D5400_RS09020	COG1410	methionine synthase
D5400_RS09020	COG0646	methionine synthase
D5400_RS09040	COG3383	formate dehydrogenase (NAD+) activity
D5400_RS09045	COG1492	cobalamin metabolic process
D5400_RS09080	COG2133	pyrroloquinoline quinone binding
D5400_RS09165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5400_RS09175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5400_RS09180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5400_RS09185	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D5400_RS09190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D5400_RS09195	COG0493	'glutamate synthase
D5400_RS09195	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5400_RS09205	COG1598	PFAM Uncharacterised protein family UPF0150
D5400_RS09225	COG1309	transcriptional regulator
D5400_RS09230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D5400_RS09255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_RS09260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_RS09280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5400_RS09300	COG0784	Response regulator, receiver
D5400_RS09305	COG3237	CsbD-like
D5400_RS09325	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS09325	COG3321	synthase
D5400_RS09325	COG0604	alcohol dehydrogenase
D5400_RS09345	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS09365	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D5400_RS09375	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D5400_RS09380	COG1686	Belongs to the peptidase S11 family
D5400_RS09395	COG3706	GGDEF domain
D5400_RS09400	COG5001	Diguanylate cyclase
D5400_RS09400	COG4251	negative regulation of phosphorylation
D5400_RS09400	COG3706	GGDEF domain
D5400_RS09400	COG2203	Gaf domain
D5400_RS09410	COG2948	multi-organism process
D5400_RS09425	COG3846	protein secretion by the type IV secretion system
D5400_RS09440	COG3451	type IV secretory pathway VirB4
D5400_RS09455	COG4962	Type ii secretion system protein e
D5400_RS09465	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS09475	COG2801	Transposase and inactivated derivatives
D5400_RS09510	COG0671	phosphoesterase, PA-phosphatase related
D5400_RS09585	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5400_RS09665	COG2132	Multicopper oxidase
D5400_RS09670	COG1321	iron dependent repressor
D5400_RS09675	COG0789	Transcriptional regulator
D5400_RS09685	COG1999	signal sequence binding
D5400_RS09705	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D5400_RS09710	COG3034	peptidoglycan biosynthetic process
D5400_RS09720	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_RS09740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5400_RS09760	COG1230	cation diffusion facilitator family transporter
D5400_RS09770	COG2217	Heavy metal translocating P-type atpase
D5400_RS09785	COG2814	Major facilitator Superfamily
D5400_RS09825	COG2132	Multicopper oxidase
D5400_RS09855	COG0556	nucleotide-excision repair
D5400_RS09875	COG0133	tryptophan synthase activity
D5400_RS09910	COG4227	nucleotidyltransferase activity
D5400_RS09925	COG4974	Belongs to the 'phage' integrase family
D5400_RS09935	COG3622	Belongs to the hyi family
D5400_RS09940	COG0235	Class ii aldolase
D5400_RS09945	COG3395	kinase activity
D5400_RS09950	COG2084	Dehydrogenase
D5400_RS09955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5400_RS09965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_RS09965	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D5400_RS09975	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_RS09980	COG2186	Transcriptional regulator
D5400_RS09985	COG1012	belongs to the aldehyde dehydrogenase family
D5400_RS09995	COG0287	Prephenate dehydrogenase
D5400_RS10000	COG1850	ribulose-bisphosphate carboxylase activity
D5400_RS10015	COG2111	Na H antiporter
D5400_RS10015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5400_RS10020	COG1006	Multisubunit Na H antiporter MnhC subunit
D5400_RS10025	COG0651	ATP synthesis coupled electron transport
D5400_RS10030	COG1863	multisubunit Na H antiporter MnhE subunit
D5400_RS10035	COG2212	antiporter activity
D5400_RS10040	COG1320	monovalent cation:proton antiporter activity
D5400_RS10070	COG1971	Probably functions as a manganese efflux pump
D5400_RS10090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_RS10120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5400_RS10125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D5400_RS10130	COG0559	Belongs to the binding-protein-dependent transport system permease family
D5400_RS10175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5400_RS10180	COG0459	protein refolding
D5400_RS10185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D5400_RS10190	COG5425	PFAM Usg family protein
D5400_RS10195	COG1253	flavin adenine dinucleotide binding
D5400_RS10200	COG0534	Mate efflux family protein
D5400_RS10205	COG0829	nickel cation binding
D5400_RS10210	COG0831	urea catabolic process
D5400_RS10215	COG0832	Belongs to the urease beta subunit family
D5400_RS10225	COG0804	urea catabolic process
D5400_RS10240	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D5400_RS10250	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D5400_RS10270	COG2308	Evidence 4 Homologs of previously reported genes of
D5400_RS10280	COG0513	Belongs to the DEAD box helicase family
D5400_RS10285	COG0683	leucine binding
D5400_RS10300	COG0559	Belongs to the binding-protein-dependent transport system permease family
D5400_RS10315	COG2113	Glycine betaine
D5400_RS10320	COG4176	ABC-type proline glycine betaine transport system permease component
D5400_RS10330	COG3850	Histidine kinase
D5400_RS10330	COG3437	response regulator, receiver
D5400_RS10330	COG2205	protein histidine kinase activity
D5400_RS10330	COG4999	Histidine kinase
D5400_RS10335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5400_RS10335	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D5400_RS10340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5400_RS10355	COG4266	Belongs to the allantoicase family
D5400_RS10360	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
D5400_RS10365	COG2351	hydroxyisourate hydrolase activity
D5400_RS10370	COG0402	S-adenosylhomocysteine deaminase activity
D5400_RS10380	COG0583	DNA-binding transcription factor activity
D5400_RS10395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D5400_RS10410	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS10440	COG2032	superoxide dismutase activity
D5400_RS10455	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D5400_RS10485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5400_RS10495	COG0667	Aldo Keto reductase
D5400_RS10510	COG1121	(ABC) transporter
D5400_RS10515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5400_RS10520	COG0735	belongs to the Fur family
D5400_RS10525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D5400_RS10530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D5400_RS10540	COG1278	Cold shock
D5400_RS10555	COG2205	protein histidine kinase activity
D5400_RS10555	COG2202	Pas domain
D5400_RS10560	COG0625	glutathione transferase activity
D5400_RS10565	COG1573	uracil-dna glycosylase
D5400_RS10570	COG1522	sequence-specific DNA binding
D5400_RS10580	COG2084	Dehydrogenase
D5400_RS10590	COG0784	Response regulator, receiver
D5400_RS10590	COG4191	Histidine kinase
D5400_RS10595	COG0784	Response regulator, receiver
D5400_RS10600	COG3920	Histidine kinase
D5400_RS10615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5400_RS10620	COG0303	'Molybdopterin
D5400_RS10630	COG0746	molybdenum cofactor guanylyltransferase activity
D5400_RS10635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D5400_RS10640	COG2814	Major facilitator Superfamily
D5400_RS10670	COG0556	nucleotide-excision repair
D5400_RS10690	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D5400_RS10710	COG5001	Diguanylate cyclase
D5400_RS10710	COG2203	Gaf domain
D5400_RS10710	COG3706	GGDEF domain
D5400_RS10710	COG4251	negative regulation of phosphorylation
D5400_RS10725	COG0659	secondary active sulfate transmembrane transporter activity
D5400_RS10745	COG5507	3-demethylubiquinone-9 3-methyltransferase
D5400_RS10755	COG1278	Cold shock
D5400_RS10765	COG4941	Belongs to the sigma-70 factor family
D5400_RS10770	COG3795	YCII-related domain
D5400_RS10780	COG5285	phytanoyl-CoA dioxygenase
D5400_RS10785	COG0730	response to heat
D5400_RS10800	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D5400_RS10805	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D5400_RS10815	COG3384	dioxygenase
D5400_RS10820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D5400_RS10840	COG0842	Transport permease protein
D5400_RS10845	COG1131	(ABC) transporter
D5400_RS10850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D5400_RS10865	COG0281	malic enzyme
D5400_RS10865	COG0280	phosphate acetyltransferase
D5400_RS10870	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5400_RS10880	COG2814	Major facilitator Superfamily
D5400_RS10885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D5400_RS10890	COG1127	ABC transporter
D5400_RS10900	COG3218	ABC-type transport auxiliary lipoprotein component
D5400_RS10900	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D5400_RS10915	COG0633	Ferredoxin
D5400_RS10920	COG0492	ferredoxin-NADP+ reductase activity
D5400_RS10930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D5400_RS10940	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D5400_RS10950	COG3768	UPF0283 membrane protein
D5400_RS10955	COG3106	COG3106 Predicted ATPase
D5400_RS10990	COG2885	chlorophyll binding
D5400_RS11000	COG2313	pseudouridylate synthase activity
D5400_RS11010	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D5400_RS11015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D5400_RS11025	COG2066	Belongs to the glutaminase family
D5400_RS11040	COG0538	isocitrate dehydrogenase activity
D5400_RS11050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D5400_RS11060	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D5400_RS11070	COG0037	tRNA processing
D5400_RS11075	COG2814	Major facilitator Superfamily
D5400_RS11080	COG2814	Major facilitator Superfamily
D5400_RS11095	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D5400_RS11120	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D5400_RS11125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D5400_RS11150	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D5400_RS11160	COG3191	aminopeptidase activity
D5400_RS11170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D5400_RS11175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D5400_RS11190	COG3608	succinylglutamate desuccinylase aspartoacylase
D5400_RS11190	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D5400_RS11220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5400_RS11225	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D5400_RS11240	COG4251	negative regulation of phosphorylation
D5400_RS11245	COG0784	Response regulator, receiver
D5400_RS11250	COG3920	Histidine kinase
D5400_RS11250	COG2202	Pas domain
D5400_RS11260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D5400_RS11275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D5400_RS11300	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D5400_RS11305	COG1671	Belongs to the UPF0178 family
D5400_RS11310	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D5400_RS11335	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D5400_RS11370	COG0679	Auxin Efflux Carrier
D5400_RS11375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5400_RS11380	COG1183	phosphatidylcholine synthase activity
D5400_RS11390	COG3845	ABC transporter
D5400_RS11395	COG4603	Belongs to the binding-protein-dependent transport system permease family
D5400_RS11400	COG1079	Belongs to the binding-protein-dependent transport system permease family
D5400_RS11410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5400_RS11425	COG1752	Esterase of the alpha-beta hydrolase superfamily
D5400_RS11430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D5400_RS11435	COG0302	gtp cyclohydrolase
D5400_RS11445	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D5400_RS11450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D5400_RS11465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D5400_RS11470	COG2301	Belongs to the HpcH HpaI aldolase family
D5400_RS11480	COG0187	DNA topoisomerase II activity
D5400_RS11585	COG3750	Belongs to the UPF0335 family
D5400_RS11720	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D5400_RS11725	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D5400_RS11735	COG2945	thiolester hydrolase activity
D5400_RS11740	COG1104	cysteine desulfurase activity
D5400_RS11745	COG0719	Fe-S assembly protein
D5400_RS11750	COG0396	ATPase activity
D5400_RS11755	COG0719	Fe-S assembly protein
D5400_RS11760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D5400_RS11765	COG2151	metal-sulfur cluster biosynthetic enzyme
D5400_RS11780	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D5400_RS11800	COG0513	Belongs to the DEAD box helicase family
D5400_RS11805	COG0739	heme binding
D5400_RS11810	COG2833	Protein of unknown function (DUF455)
D5400_RS11815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D5400_RS11825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5400_RS11855	COG1136	(ABC) transporter
D5400_RS11870	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D5400_RS11885	COG0071	Belongs to the small heat shock protein (HSP20) family
D5400_RS11925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5400_RS11935	COG2188	Transcriptional regulator
D5400_RS11965	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D5400_RS11970	COG0066	3-isopropylmalate dehydratase activity
D5400_RS11990	COG1335	isochorismatase
D5400_RS11995	COG1053	succinate dehydrogenase
D5400_RS12005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D5400_RS12015	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D5400_RS12025	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D5400_RS12030	COG0081	regulation of translation
D5400_RS12035	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D5400_RS12040	COG0222	ribosome binding
D5400_RS12045	COG0085	RNA polymerase activity
D5400_RS12050	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D5400_RS12060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D5400_RS12065	COG0049	tRNA binding
D5400_RS12070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D5400_RS12075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D5400_RS12085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D5400_RS12090	COG0088	Forms part of the polypeptide exit tunnel
D5400_RS12095	COG0089	rRNA binding
D5400_RS12100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D5400_RS12105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D5400_RS12110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D5400_RS12115	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D5400_RS12120	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D5400_RS12125	COG0255	Belongs to the universal ribosomal protein uL29 family
D5400_RS12130	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D5400_RS12135	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D5400_RS12140	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D5400_RS12145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D5400_RS12150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D5400_RS12155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D5400_RS12160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D5400_RS12165	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D5400_RS12170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D5400_RS12175	COG1841	ribosomal large subunit assembly
D5400_RS12180	COG0200	Binds to the 23S rRNA
D5400_RS12190	COG0563	adenylate kinase activity
D5400_RS12195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D5400_RS12200	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D5400_RS12205	COG0202	RNA polymerase activity
D5400_RS12210	COG0203	ribosomal protein L17
D5400_RS12230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5400_RS12240	COG0306	phosphate transporter
D5400_RS12250	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS12255	COG2207	Transcriptional regulator
D5400_RS12260	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D5400_RS12265	COG1546	Belongs to the CinA family
D5400_RS12265	COG1058	Belongs to the CinA family
D5400_RS12270	COG0655	NAD(P)H dehydrogenase (quinone) activity
D5400_RS12295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D5400_RS12305	COG3706	GGDEF domain
D5400_RS12310	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D5400_RS12310	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D5400_RS12315	COG2989	Protein conserved in bacteria
D5400_RS12320	COG0546	phosphoglycolate phosphatase activity
D5400_RS12325	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D5400_RS12340	COG4770	biotin carboxylase activity
D5400_RS12345	COG0321	lipoyl(octanoyl) transferase activity
D5400_RS12445	COG3750	Belongs to the UPF0335 family
D5400_RS12500	COG0616	signal peptide processing
D5400_RS12645	COG2239	Acts as a magnesium transporter
D5400_RS12660	COG0656	L-ascorbic acid biosynthetic process
D5400_RS12670	COG1760	l-serine dehydratase
D5400_RS12700	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D5400_RS12720	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D5400_RS12720	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D5400_RS12730	COG3852	Histidine kinase
D5400_RS12735	COG2204	response regulator
D5400_RS12740	COG5000	phosphorelay sensor kinase activity
D5400_RS12745	COG2204	response regulator
D5400_RS12775	COG3842	ATPase activity
D5400_RS12780	COG0010	Belongs to the arginase family
D5400_RS12795	COG3795	YCII-related domain
D5400_RS12820	COG1686	Belongs to the peptidase S11 family
D5400_RS12825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D5400_RS12835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5400_RS12840	COG0084	hydrolase, TatD family'
D5400_RS12845	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D5400_RS12845	COG0321	lipoyl(octanoyl) transferase activity
D5400_RS12855	COG3956	TIGRFAM MazG family protein
D5400_RS12860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D5400_RS12865	COG1923	regulation of RNA biosynthetic process
D5400_RS12870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5400_RS12875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5400_RS12880	COG0569	domain protein
D5400_RS12895	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D5400_RS12900	COG0629	single-stranded DNA binding
D5400_RS12905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D5400_RS12910	COG0625	glutathione transferase activity
D5400_RS12920	COG0347	Belongs to the P(II) protein family
D5400_RS12925	COG0174	glutamine synthetase
D5400_RS12935	COG0514	ATP-dependent DNA helicase (RecQ)
D5400_RS12945	COG1704	LemA family
D5400_RS12955	COG0668	transmembrane transport
D5400_RS12985	COG1960	acyl-CoA dehydrogenase activity
D5400_RS13000	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D5400_RS13010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D5400_RS13010	COG1648	precorrin-2 dehydrogenase activity
D5400_RS13020	COG0343	queuine tRNA-ribosyltransferase activity
D5400_RS13025	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D5400_RS13045	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D5400_RS13050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D5400_RS13055	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5400_RS13060	COG3494	Protein of unknown function (DUF1009)
D5400_RS13065	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5400_RS13070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5400_RS13075	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5400_RS13080	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D5400_RS13085	COG0750	zinc metalloprotease
D5400_RS13095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D5400_RS13100	COG0233	cytoplasmic translational termination
D5400_RS13105	COG0528	UMP kinase activity
D5400_RS13110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D5400_RS13115	COG0052	Belongs to the universal ribosomal protein uS2 family
D5400_RS13120	COG0784	Response regulator, receiver
D5400_RS13120	COG2198	Histidine kinase
D5400_RS13120	COG5002	protein histidine kinase activity
D5400_RS13125	COG0784	Response regulator, receiver
D5400_RS13130	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D5400_RS13140	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
D5400_RS13145	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D5400_RS13175	COG0537	adenosine 5'-monophosphoramidase activity
D5400_RS13180	COG2867	negative regulation of translational initiation
D5400_RS13185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D5400_RS13195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5400_RS13205	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5400_RS13210	COG0022	dehydrogenase e1 component
D5400_RS13210	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5400_RS13215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D5400_RS13235	COG2358	TRAP transporter, solute receptor (TAXI family
D5400_RS13260	COG0516	GMP reductase activity
D5400_RS13260	COG0517	IMP dehydrogenase activity
D5400_RS13295	COG1045	serine acetyltransferase
D5400_RS13300	COG0596	Alpha beta hydrolase
D5400_RS13300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D5400_RS13320	COG1126	abc transporter atp-binding protein
D5400_RS13325	COG0765	amino acid transport
D5400_RS13330	COG4597	amino acid ABC transporter
D5400_RS13335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5400_RS13340	COG0626	cystathionine gamma-synthase activity
D5400_RS13355	COG0148	phosphopyruvate hydratase activity
D5400_RS13365	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D5400_RS13375	COG0504	CTP synthase activity
D5400_RS13385	COG0149	triose-phosphate isomerase activity
D5400_RS13390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5400_RS13395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D5400_RS13400	COG0134	indole-3-glycerol-phosphate synthase activity
D5400_RS13410	COG0303	'Molybdopterin
D5400_RS13415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D5400_RS13435	COG2095	MarC family integral membrane protein
D5400_RS13455	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D5400_RS13460	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5400_RS13465	COG1530	ribonuclease E activity
D5400_RS13465	COG1530	ribonuclease E activity
D5400_RS13470	COG0436	Aminotransferase
D5400_RS13485	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D5400_RS13490	COG0511	ligase activity, forming carbon-carbon bonds
D5400_RS13500	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D5400_RS13525	COG3243	poly(R)-hydroxyalkanoic acid synthase
D5400_RS13530	COG1489	DNA binding
D5400_RS13535	COG0024	Methionine aminopeptidase
D5400_RS13540	COG2003	Belongs to the UPF0758 family
D5400_RS13545	COG3046	protein related to deoxyribodipyrimidine photolyase
D5400_RS13550	COG0544	peptidyl-prolyl cis-trans isomerase activity
D5400_RS13575	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D5400_RS13610	COG1862	Preprotein translocase
D5400_RS13625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D5400_RS13630	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D5400_RS13635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D5400_RS13640	COG0805	protein transport
D5400_RS13645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5400_RS13650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5400_RS13655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D5400_RS13660	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D5400_RS13665	COG1472	Belongs to the glycosyl hydrolase 3 family
D5400_RS13675	COG0018	arginyl-trna synthetase
D5400_RS13680	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D5400_RS13690	COG0708	Exodeoxyribonuclease III
D5400_RS13700	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D5400_RS13705	COG0129	dihydroxy-acid dehydratase activity
D5400_RS13715	COG0525	valine-tRNA ligase activity
D5400_RS13730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D5400_RS13740	COG0850	regulation of cytokinetic process
D5400_RS13750	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D5400_RS13770	COG0415	Belongs to the DNA photolyase family
D5400_RS13785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D5400_RS13790	COG2211	Major facilitator Superfamily
D5400_RS13795	COG4221	oxidoreductase activity
D5400_RS13800	COG3806	Anti-sigma factor
D5400_RS13805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D5400_RS13815	COG2897	thiosulfate sulfurtransferase activity
D5400_RS13825	COG0686	Belongs to the AlaDH PNT family
D5400_RS13830	COG1522	sequence-specific DNA binding
D5400_RS13835	COG2814	Major facilitator Superfamily
D5400_RS13845	COG0737	Belongs to the 5'-nucleotidase family
D5400_RS13850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D5400_RS13855	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D5400_RS13860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D5400_RS13870	COG0785	Cytochrome C biogenesis protein
D5400_RS14080	COG3750	Belongs to the UPF0335 family
D5400_RS14190	COG2200	EAL domain
D5400_RS14190	COG2203	Gaf domain
D5400_RS14190	COG2199	diguanylate cyclase activity
D5400_RS14200	COG1278	Cold shock
D5400_RS14205	COG0346	lactoylglutathione lyase activity
D5400_RS14220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D5400_RS14230	COG0436	Aminotransferase
D5400_RS14240	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D5400_RS14250	COG0154	amidase activity
D5400_RS14260	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D5400_RS14265	COG3300	MHYT domain
D5400_RS14265	COG5001	Diguanylate cyclase
D5400_RS14270	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D5400_RS14275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D5400_RS14295	COG1960	acyl-CoA dehydrogenase activity
D5400_RS14300	COG0540	Belongs to the ATCase OTCase family
D5400_RS14315	COG0758	DNA mediated transformation
D5400_RS14325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D5400_RS14330	COG0557	exoribonuclease II activity
D5400_RS14360	COG0784	Response regulator, receiver
D5400_RS14375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D5400_RS14390	COG1136	(ABC) transporter
D5400_RS14400	COG0442	prolyl-tRNA aminoacylation
D5400_RS14410	COG0346	lactoylglutathione lyase activity
D5400_RS14425	COG1007	ATP synthesis coupled electron transport
D5400_RS14440	COG0713	ATP synthesis coupled electron transport
D5400_RS14450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5400_RS14455	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D5400_RS14470	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D5400_RS14475	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D5400_RS14485	COG0649	NAD binding
D5400_RS14490	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5400_RS14495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5400_RS14500	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5400_RS14520	COG0247	lactate metabolic process
D5400_RS14530	COG0277	FAD linked oxidase domain protein
D5400_RS14535	COG0277	FAD linked oxidase domain protein
D5400_RS14540	COG0583	DNA-binding transcription factor activity
D5400_RS14555	COG0247	lactate metabolic process
D5400_RS14560	COG1139	Iron-sulfur cluster binding protein
D5400_RS14565	COG1556	Lactate utilization protein
D5400_RS14600	COG0583	DNA-binding transcription factor activity
D5400_RS14605	COG1570	exodeoxyribonuclease VII activity
D5400_RS14610	COG2354	Protein conserved in bacteria
D5400_RS14620	COG4948	Mandelate Racemase Muconate Lactonizing
D5400_RS14625	COG0747	negative chemotaxis
D5400_RS14630	COG0601	transmembrane transport
D5400_RS14635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5400_RS14640	COG0444	Belongs to the ABC transporter superfamily
D5400_RS14645	COG4608	Belongs to the ABC transporter superfamily
D5400_RS14650	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D5400_RS14655	COG4187	Peptidase family M20/M25/M40
D5400_RS14660	COG0776	regulation of translation
D5400_RS14665	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D5400_RS14670	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D5400_RS14675	COG0740	serine-type endopeptidase activity
D5400_RS14685	COG2124	cytochrome p450
D5400_RS14700	COG1832	CoA-binding protein
D5400_RS14710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_RS14715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D5400_RS14715	COG1116	anion transmembrane transporter activity
D5400_RS14720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D5400_RS14730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D5400_RS14735	COG1024	Enoyl-CoA hydratase
D5400_RS14745	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D5400_RS14750	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D5400_RS14760	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D5400_RS14765	COG1612	heme a metabolic process
D5400_RS14810	COG0667	Aldo Keto reductase
D5400_RS14830	COG0776	regulation of translation
D5400_RS14835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5400_RS14840	COG0416	fatty acid biosynthetic process
D5400_RS14860	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D5400_RS14865	COG2814	Major facilitator Superfamily
D5400_RS14870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D5400_RS14885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5400_RS14885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5400_RS14890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D5400_RS14895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D5400_RS14900	COG2207	Transcriptional regulator
D5400_RS14910	COG2989	Protein conserved in bacteria
D5400_RS14925	COG0113	porphobilinogen synthase activity
D5400_RS14935	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D5400_RS14945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D5400_RS14960	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D5400_RS14965	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D5400_RS14980	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D5400_RS14990	COG0628	permease
D5400_RS14995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D5400_RS15000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D5400_RS15005	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D5400_RS15010	COG0243	molybdopterin cofactor binding
D5400_RS15015	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D5400_RS15030	COG0625	glutathione transferase activity
D5400_RS15045	COG0322	excinuclease ABC activity
D5400_RS15055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D5400_RS15065	COG0314	molybdopterin synthase activity
D5400_RS15070	COG0175	sulfate reduction
D5400_RS15075	COG0105	UTP biosynthetic process
D5400_RS15085	COG0488	(ABC) transporter
D5400_RS15105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D5400_RS15120	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D5400_RS15130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D5400_RS15135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D5400_RS15140	COG0194	GDP metabolic process
D5400_RS15145	COG1561	YicC-like family, N-terminal region
D5400_RS15150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D5400_RS15155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5400_RS15160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5400_RS15170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D5400_RS15175	COG0360	Binds together with S18 to 16S ribosomal RNA
D5400_RS15190	COG0359	binds to the 23S rRNA
D5400_RS15195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D5400_RS15205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D5400_RS15220	COG3609	addiction module antidote protein, CC2985 family
D5400_RS15245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D5400_RS15250	COG4221	oxidoreductase activity
D5400_RS15255	COG1183	phosphatidylcholine synthase activity
D5400_RS15260	COG0688	phosphatidylethanolamine metabolic process
D5400_RS15265	COG5265	(ABC) transporter
D5400_RS15285	COG3153	acetyltransferase
D5400_RS15285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5400_RS15300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5400_RS15320	COG0215	cysteine-tRNA ligase activity
D5400_RS15345	COG0494	nUDIX hydrolase
D5400_RS15365	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D5400_RS15385	COG1595	DNA-templated transcription, initiation
D5400_RS15400	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D5400_RS15405	COG1388	LysM domain
D5400_RS15405	COG3409	Peptidoglycan-binding domain 1 protein
D5400_RS15405	COG5632	N-Acetylmuramoyl-L-alanine amidase
D5400_RS15410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D5400_RS15430	COG1381	Involved in DNA repair and RecF pathway recombination
D5400_RS15435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D5400_RS15440	COG0571	ribonuclease III activity
D5400_RS15445	COG0681	Belongs to the peptidase S26 family
D5400_RS15450	COG0736	holo-[acyl-carrier-protein] synthase activity
D5400_RS15465	COG1758	RNA polymerase activity
D5400_RS15475	COG1573	uracil-dna glycosylase
D5400_RS15490	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D5400_RS15495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D5400_RS15500	COG0741	lytic transglycosylase activity
D5400_RS15515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D5400_RS15520	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D5400_RS15545	COG0811	peptide transport
D5400_RS15565	COG1132	(ABC) transporter
D5400_RS15600	COG0156	8-amino-7-oxononanoate synthase activity
D5400_RS15625	COG1091	dTDP-4-dehydrorhamnose reductase activity
D5400_RS15665	COG0438	transferase activity, transferring glycosyl groups
D5400_RS15665	COG1216	Glycosyl transferase, family 2
D5400_RS15675	COG4221	oxidoreductase activity
D5400_RS15765	COG1061	Type III restriction enzyme res subunit
D5400_RS15800	COG1475	DNA binding
D5400_RS15950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5400_RS15950	COG3453	Protein conserved in bacteria
D5400_RS15955	COG3453	Protein conserved in bacteria
D5400_RS15955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5400_RS15975	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_RS15980	COG4232	protein-disulfide reductase activity
D5400_RS15985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5400_RS16010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D5400_RS16015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_RS16020	COG1116	anion transmembrane transporter activity
D5400_RS16025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5400_RS16030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D5400_RS16035	COG2011	ABC-type metal ion transport system permease component
D5400_RS16045	COG0431	NADPH-dependent FMN reductase
D5400_RS16065	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D5400_RS16070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_RS16080	COG1959	2 iron, 2 sulfur cluster binding
D5400_RS16090	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D5400_RS16100	COG3206	protein involved in exopolysaccharide biosynthesis
D5400_RS16100	COG0489	protein tyrosine kinase activity
D5400_RS16105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D5400_RS16110	COG1215	transferase activity, transferring glycosyl groups
D5400_RS16115	COG1215	transferase activity, transferring glycosyl groups
D5400_RS16120	COG1215	transferase activity, transferring glycosyl groups
D5400_RS16125	COG0438	transferase activity, transferring glycosyl groups
D5400_RS16130	COG2273	Hydrolase Family 16
D5400_RS16135	COG2244	polysaccharide biosynthetic process
D5400_RS16140	COG0463	Glycosyl transferase, family 2
D5400_RS16145	COG2327	Polysaccharide pyruvyl transferase
D5400_RS16150	COG1215	transferase activity, transferring glycosyl groups
D5400_RS16165	COG1596	polysaccharide export
D5400_RS16170	COG3307	-O-antigen
D5400_RS16205	COG0583	DNA-binding transcription factor activity
D5400_RS16215	COG1215	transferase activity, transferring glycosyl groups
D5400_RS16240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5400_RS16255	COG3706	GGDEF domain
D5400_RS16270	COG1120	ATPase activity
D5400_RS16275	COG4774	siderophore transport
D5400_RS16280	COG0679	Auxin Efflux Carrier
D5400_RS16285	COG1238	metal cluster binding
D5400_RS16290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5400_RS16310	COG0625	glutathione transferase activity
D5400_RS16315	COG0628	permease
D5400_RS16320	COG0840	transmembrane signaling receptor activity
D5400_RS16325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D5400_RS16350	COG1573	uracil-dna glycosylase
D5400_RS16360	COG3920	Histidine kinase
D5400_RS16380	COG0308	aminopeptidase N
D5400_RS16385	COG2205	protein histidine kinase activity
D5400_RS16385	COG2202	Pas domain
D5400_RS16395	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D5400_RS16400	COG2205	protein histidine kinase activity
D5400_RS16410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5400_RS16415	COG3088	subunit of a heme lyase
D5400_RS16420	COG1138	Cytochrome C-type biogenesis protein
D5400_RS16425	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D5400_RS16430	COG4235	cytochrome complex assembly
D5400_RS16485	COG2983	Belongs to the UPF0260 family
D5400_RS16490	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D5400_RS16525	COG2205	protein histidine kinase activity
D5400_RS16535	COG2166	iron-sulfur cluster assembly
D5400_RS16550	COG4957	zinc ion binding
D5400_RS16555	COG1320	monovalent cation:proton antiporter activity
D5400_RS16560	COG2212	antiporter activity
D5400_RS16565	COG1863	multisubunit Na H antiporter MnhE subunit
D5400_RS16570	COG0651	ATP synthesis coupled electron transport
D5400_RS16575	COG1006	Multisubunit Na H antiporter MnhC subunit
D5400_RS16580	COG2111	Na H antiporter
D5400_RS16585	COG2111	Na H antiporter
D5400_RS16585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5400_RS16590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5400_RS16605	COG2010	Cytochrome c
D5400_RS16615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D5400_RS16620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5400_RS16630	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_RS16635	COG0433	COG0433 Predicted ATPase
D5400_RS16665	COG3685	Protein conserved in bacteria
D5400_RS16690	COG0489	protein tyrosine kinase activity
D5400_RS16700	COG1176	ABC-type spermidine putrescine transport system, permease component I
D5400_RS16705	COG3842	ATPase activity
D5400_RS16710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D5400_RS16715	COG0784	Response regulator, receiver
D5400_RS16715	COG4191	Histidine kinase
D5400_RS16885	COG4695	Portal protein
D5400_RS16945	COG3750	Belongs to the UPF0335 family
D5400_RS17025	COG2030	dehydratase
D5400_RS17035	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_RS17050	COG1268	BioY protein
D5400_RS17080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5400_RS17080	COG0574	Belongs to the PEP-utilizing enzyme family
D5400_RS17090	COG1196	nuclear chromosome segregation
D5400_RS17105	COG1194	a g-specific adenine glycosylase
D5400_RS17115	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D5400_RS17120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5400_RS17135	COG0612	Peptidase, M16
D5400_RS17140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5400_RS17145	COG5001	Diguanylate cyclase
D5400_RS17145	COG3300	MHYT domain
D5400_RS17150	COG1678	Uncharacterized ACR, COG1678
D5400_RS17160	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D5400_RS17160	COG0678	peroxiredoxin activity
D5400_RS17165	COG0328	RNA-DNA hybrid ribonuclease activity
D5400_RS17170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D5400_RS17175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D5400_RS17180	COG3346	SURF1 family
D5400_RS17195	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D5400_RS17200	COG0109	protoheme IX farnesyltransferase activity
D5400_RS17205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D5400_RS17210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D5400_RS17220	COG0312	modulator of DNA gyrase
D5400_RS17225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D5400_RS17235	COG0259	pyridoxamine-phosphate oxidase activity
D5400_RS17245	COG0484	heat shock protein binding
D5400_RS17250	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D5400_RS17255	COG0406	alpha-ribazole phosphatase activity
D5400_RS17260	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D5400_RS17265	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D5400_RS17265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D5400_RS17270	COG0123	including yeast histone deacetylase and acetoin utilization protein
D5400_RS17275	COG1722	exodeoxyribonuclease VII activity
D5400_RS17280	COG5001	Diguanylate cyclase
D5400_RS17280	COG3300	MHYT domain
D5400_RS17285	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D5400_RS17300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5400_RS17305	COG1024	Enoyl-CoA hydratase
D5400_RS17310	COG1960	acyl-CoA dehydrogenase activity
D5400_RS17315	COG0009	L-threonylcarbamoyladenylate synthase
D5400_RS17335	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D5400_RS17340	COG0151	Belongs to the GarS family
D5400_RS17355	COG0751	glycine-tRNA ligase activity
D5400_RS17360	COG0752	glycyl-tRNA synthetase alpha subunit
D5400_RS17385	COG0142	geranyltranstransferase activity
D5400_RS17395	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D5400_RS17400	COG0521	Mo-molybdopterin cofactor biosynthetic process
D5400_RS17415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D5400_RS17420	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D5400_RS17425	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D5400_RS17430	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5400_RS17435	COG0356	it plays a direct role in the translocation of protons across the membrane
D5400_RS17450	COG1160	GTP binding
D5400_RS17465	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
D5400_RS17470	COG0477	Major facilitator Superfamily
D5400_RS17485	COG0861	Integral membrane protein TerC family
D5400_RS17490	COG2217	Heavy metal translocating P-type atpase
D5400_RS17510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5400_RS17520	COG4566	intracellular signal transduction
D5400_RS17525	COG4191	Histidine kinase
D5400_RS17530	COG0519	Catalyzes the synthesis of GMP from XMP
D5400_RS17530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D5400_RS17570	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D5400_RS17575	COG0248	Ppx GppA phosphatase
D5400_RS17595	COG0210	DNA helicase
D5400_RS17605	COG3706	GGDEF domain
D5400_RS17610	COG0784	Response regulator, receiver
D5400_RS17610	COG4191	Histidine kinase
D5400_RS17650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_RS17670	COG0702	epimerase
D5400_RS17675	COG3631	Ketosteroid isomerase-related protein
D5400_RS17680	COG1309	transcriptional regulator
D5400_RS17690	COG0300	oxidoreductase activity
D5400_RS17705	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5400_RS17720	COG4221	oxidoreductase activity
D5400_RS17730	COG1309	transcriptional regulator
D5400_RS17735	COG1505	serine-type exopeptidase activity
D5400_RS17745	COG0642	Histidine kinase
D5400_RS17755	COG1073	alpha beta
D5400_RS17760	COG2186	Transcriptional regulator
D5400_RS17765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_RS17775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_RS17785	COG1850	ribulose-bisphosphate carboxylase activity
D5400_RS17805	COG0300	oxidoreductase activity
D5400_RS17865	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D5400_RS17870	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D5400_RS17875	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D5400_RS17880	COG2205	protein histidine kinase activity
D5400_RS17885	COG0745	RESPONSE REGULATOR receiver
D5400_RS17895	COG0010	Belongs to the arginase family
D5400_RS17900	COG1522	sequence-specific DNA binding
D5400_RS17925	COG4608	Belongs to the ABC transporter superfamily
D5400_RS17930	COG0444	Belongs to the ABC transporter superfamily
D5400_RS17935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5400_RS17965	COG1819	glycosyl
D5400_RS17975	COG3604	Transcriptional regulator
D5400_RS17980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D5400_RS17980	COG1116	anion transmembrane transporter activity
D5400_RS17985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_RS17990	COG1116	anion transmembrane transporter activity
D5400_RS17995	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
D5400_RS18010	COG1024	Enoyl-CoA hydratase
D5400_RS18040	COG1609	Transcriptional regulator
D5400_RS18050	COG1879	ABC-type sugar transport system periplasmic component
D5400_RS18055	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5400_RS18060	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5400_RS18065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5400_RS18075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D5400_RS18080	COG2072	flavoprotein involved in K transport
D5400_RS18090	COG2144	transferase activity, transferring acyl groups
D5400_RS18100	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D5400_RS18115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5400_RS18140	COG2207	Transcriptional regulator
D5400_RS18145	COG3034	peptidoglycan biosynthetic process
D5400_RS18160	COG1126	abc transporter atp-binding protein
D5400_RS18180	COG0708	Exodeoxyribonuclease III
D5400_RS18195	COG2197	response regulator
D5400_RS18210	COG0667	Aldo Keto reductase
D5400_RS18220	COG2376	Dihydroxyacetone kinase
D5400_RS18225	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5400_RS18230	COG1129	ABC transporter
D5400_RS18240	COG1070	Carbohydrate kinase
D5400_RS18250	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5400_RS18255	COG0434	BtpA family
D5400_RS18260	COG1349	DNA-binding transcription factor activity
D5400_RS18265	COG2186	Transcriptional regulator
D5400_RS18270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_RS18285	COG0698	ribose 5-phosphate isomerase
D5400_RS18340	COG1278	Cold shock
D5400_RS18350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5400_RS18355	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D5400_RS18365	COG0410	ABC transporter
D5400_RS18405	COG1012	belongs to the aldehyde dehydrogenase family
D5400_RS18415	COG3485	protocatechuate 3,4-dioxygenase
D5400_RS18440	COG1137	ATPase activity
D5400_RS18450	COG1454	alcohol dehydrogenase
D5400_RS18470	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
D5400_RS18475	COG0183	Belongs to the thiolase family
D5400_RS18485	COG0154	amidase activity
D5400_RS18500	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D5400_RS18510	COG2864	formate dehydrogenase
D5400_RS18515	COG0437	4 iron, 4 sulfur cluster binding
D5400_RS18520	COG3383	formate dehydrogenase (NAD+) activity
D5400_RS18520	COG0243	molybdopterin cofactor binding
D5400_RS18570	COG2197	response regulator
D5400_RS18575	COG4585	Histidine kinase
D5400_RS18600	COG4181	ATPase activity
D5400_RS18615	COG0798	PFAM Bile acid sodium symporter
D5400_RS18620	COG1404	Belongs to the peptidase S8 family
D5400_RS18635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5400_RS18660	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D5400_RS18665	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D5400_RS18670	COG3485	protocatechuate 3,4-dioxygenase
D5400_RS18675	COG3485	protocatechuate 3,4-dioxygenase
D5400_RS18680	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D5400_RS18685	COG2267	carboxylic ester hydrolase activity
D5400_RS18690	COG0583	DNA-binding transcription factor activity
D5400_RS18695	COG2197	response regulator
D5400_RS18700	COG0318	PFAM AMP-dependent synthetase and ligase
D5400_RS18710	COG5001	Diguanylate cyclase
D5400_RS18710	COG3300	MHYT domain
D5400_RS18720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5400_RS18725	COG1321	iron dependent repressor
D5400_RS18725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5400_RS18730	COG1121	(ABC) transporter
D5400_RS18735	COG0803	Belongs to the bacterial solute-binding protein 9 family
D5400_RS18740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D5400_RS18750	COG1663	tetraacyldisaccharide 4'-kinase activity
D5400_RS18755	COG1519	Transferase
D5400_RS18770	COG0483	inositol monophosphate 1-phosphatase activity
D5400_RS18775	COG0312	modulator of DNA gyrase
D5400_RS18790	COG0742	ribosomal rna small subunit methyltransferase
D5400_RS18795	COG1187	pseudouridine synthase activity
D5400_RS18800	COG0590	tRNA wobble adenosine to inosine editing
D5400_RS18810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D5400_RS18815	COG0196	riboflavin kinase activity
D5400_RS18825	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D5400_RS18830	COG0459	protein refolding
D5400_RS18835	COG1733	regulation of RNA biosynthetic process
D5400_RS18855	COG0625	glutathione transferase activity
D5400_RS18860	COG0730	response to heat
D5400_RS18875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D5400_RS18880	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D5400_RS18885	COG0124	histidyl-tRNA synthetase
D5400_RS18905	COG2818	Glycosylase
D5400_RS18910	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_RS18915	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_RS18915	COG1388	LysM domain
D5400_RS18920	COG0482	sulfurtransferase activity
D5400_RS18965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5400_RS18975	COG0564	pseudouridine synthase activity
D5400_RS18980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D5400_RS18990	COG3038	cytochrome b561
D5400_RS19000	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D5400_RS19025	COG1047	Peptidyl-prolyl cis-trans
D5400_RS19030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5400_RS19075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5400_RS19080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D5400_RS19085	COG0037	tRNA processing
D5400_RS19095	COG2885	chlorophyll binding
D5400_RS19110	COG0848	biopolymer transport protein
D5400_RS19120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5400_RS19125	COG0824	Thioesterase
D5400_RS19150	COG2255	four-way junction helicase activity
D5400_RS19155	COG0632	four-way junction helicase activity
D5400_RS19160	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D5400_RS19165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D5400_RS19175	COG0217	transcriptional regulatory protein
D5400_RS19190	COG1253	flavin adenine dinucleotide binding
D5400_RS19195	COG1692	metallophosphoesterase
D5400_RS19235	COG3263	regulation of cellular component size
D5400_RS19240	COG0126	phosphoglycerate kinase activity
D5400_RS19245	COG3588	fructose-bisphosphate aldolase
D5400_RS19260	COG0457	Tetratricopeptide repeat
D5400_RS19265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D5400_RS19270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D5400_RS19290	COG0640	Transcriptional regulator
D5400_RS19295	COG0318	PFAM AMP-dependent synthetase and ligase
D5400_RS19320	COG0483	inositol monophosphate 1-phosphatase activity
D5400_RS19335	COG1132	(ABC) transporter
D5400_RS19340	COG0254	rRNA binding
D5400_RS19355	COG3321	synthase
D5400_RS19355	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS19355	COG0604	alcohol dehydrogenase
D5400_RS19365	COG0469	pyruvate kinase activity
D5400_RS19380	COG3750	Belongs to the UPF0335 family
D5400_RS19385	COG2862	Uncharacterized protein family, UPF0114
D5400_RS19395	COG2204	response regulator
D5400_RS19410	COG3668	Plasmid stabilization system
D5400_RS19420	COG5310	Homospermidine synthase
D5400_RS19430	COG0737	Belongs to the 5'-nucleotidase family
D5400_RS19435	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D5400_RS19450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D5400_RS19455	COG2951	lytic endotransglycosylase activity
D5400_RS19470	COG0070	glutamate synthase
D5400_RS19470	COG0069	glutamate synthase activity
D5400_RS19470	COG0067	glutamate synthase
D5400_RS19485	COG0071	Belongs to the small heat shock protein (HSP20) family
D5400_RS19490	COG2267	carboxylic ester hydrolase activity
D5400_RS19530	COG4214	carbohydrate transport
D5400_RS19535	COG0559	Belongs to the binding-protein-dependent transport system permease family
D5400_RS19570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D5400_RS19570	COG0446	pyridine nucleotide-disulphide oxidoreductase
D5400_RS19580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5400_RS19585	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D5400_RS19620	COG5001	Diguanylate cyclase
D5400_RS19620	COG3300	MHYT domain
D5400_RS19630	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS19635	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D5400_RS19640	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D5400_RS19645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D5400_RS19650	COG1609	Transcriptional regulator
D5400_RS19670	COG0523	cobalamin synthesis protein
D5400_RS19700	COG0583	DNA-binding transcription factor activity
D5400_RS19730	COG0471	metal ion transport
D5400_RS19730	COG3273	potassium ion transport
D5400_RS19755	COG0800	Aldolase
D5400_RS19765	COG1054	Belongs to the UPF0176 family
D5400_RS19775	COG1879	ABC-type sugar transport system periplasmic component
D5400_RS19780	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5400_RS19785	COG1129	ABC transporter
D5400_RS19790	COG0673	inositol 2-dehydrogenase activity
D5400_RS19800	COG1609	Transcriptional regulator
D5400_RS19805	COG2115	Belongs to the xylose isomerase family
D5400_RS19810	COG1070	Carbohydrate kinase
D5400_RS19815	COG1609	Transcriptional regulator
D5400_RS19825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5400_RS19830	COG0765	amino acid transport
D5400_RS19835	COG0765	amino acid transport
D5400_RS19840	COG1126	abc transporter atp-binding protein
D5400_RS19845	COG1846	Transcriptional regulator
D5400_RS19860	COG4206	TonB-dependent receptor
D5400_RS19870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5400_RS19875	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D5400_RS19920	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D5400_RS19930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D5400_RS19955	COG1959	2 iron, 2 sulfur cluster binding
D5400_RS19960	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D5400_RS19970	COG4208	sulfate ABC transporter
D5400_RS19975	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D5400_RS19985	COG3273	potassium ion transport
D5400_RS19985	COG0471	metal ion transport
D5400_RS19995	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
D5400_RS20000	COG4423	Transcription factor
D5400_RS20035	COG1122	ATPase activity
D5400_RS20040	COG1268	BioY protein
D5400_RS20055	COG0028	Belongs to the TPP enzyme family
D5400_RS20060	COG0235	Class ii aldolase
D5400_RS20070	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_RS20115	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_RS20135	COG2963	transposase activity
D5400_RS20145	COG1414	Transcriptional regulator
D5400_RS20150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D5400_RS20160	COG0439	Biotin carboxylase
D5400_RS20170	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D5400_RS20180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_RS20185	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS20190	COG1335	isochorismatase
D5400_RS20195	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS20205	COG2267	carboxylic ester hydrolase activity
D5400_RS20210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5400_RS20215	COG4569	acetaldehyde dehydrogenase (acetylating) activity
D5400_RS20235	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D5400_RS20245	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_RS20260	COG4638	Rieske (2fe-2S)
D5400_RS20275	COG1414	Transcriptional regulator
D5400_RS20290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5400_RS20305	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D5400_RS20330	COG4227	nucleotidyltransferase activity
D5400_RS20355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D5400_RS20395	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D5400_RS20400	COG0459	protein refolding
D5400_RS20425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5400_RS20445	COG0659	secondary active sulfate transmembrane transporter activity
D5400_RS20450	COG0589	response to stress
D5400_RS20460	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D5400_RS20460	COG2755	lipolytic protein G-D-S-L family
D5400_RS20480	COG1910	domain protein
D5400_RS20530	COG0739	heme binding
D5400_RS20535	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_RS20540	COG0542	response to heat
D5400_RS20550	COG2890	protein-(glutamine-N5) methyltransferase activity
D5400_RS20555	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D5400_RS20560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5400_RS20565	COG0527	aspartate kinase activity
D5400_RS20570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5400_RS20590	COG1040	competence protein
D5400_RS20610	COG0494	nUDIX hydrolase
D5400_RS20620	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D5400_RS20625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5400_RS20630	COG0653	protein targeting
D5400_RS20645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5400_RS20665	COG2176	DNA-directed DNA polymerase activity
D5400_RS20680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5400_RS20690	COG1295	ribonuclease BN
D5400_RS20695	COG0300	oxidoreductase activity
D5400_RS20715	COG2086	electron transfer activity
D5400_RS20725	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5400_RS20730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5400_RS20735	COG0165	Argininosuccinate lyase
D5400_RS20745	COG0019	diaminopimelate decarboxylase activity
D5400_RS20765	COG0784	Response regulator, receiver
D5400_RS20765	COG4191	Histidine kinase
D5400_RS20770	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D5400_RS20780	COG2884	Cell division ATP-binding protein ftsE
D5400_RS20810	COG0287	Prephenate dehydrogenase
D5400_RS20815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5400_RS20820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D5400_RS20825	COG2813	Specifically methylates the guanine in position
D5400_RS20825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D5400_RS20840	COG2226	methyltransferase
D5400_RS20850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5400_RS20870	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D5400_RS20875	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D5400_RS20905	COG4536	flavin adenine dinucleotide binding
D5400_RS20910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D5400_RS20915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D5400_RS20925	COG4974	Belongs to the 'phage' integrase family
D5400_RS20930	COG0825	malonyl-CoA metabolic process
D5400_RS20945	COG1960	acyl-CoA dehydrogenase activity
D5400_RS20950	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5400_RS20950	COG1024	Enoyl-CoA hydratase
D5400_RS20960	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_RS20965	COG1902	pentaerythritol trinitrate reductase activity
D5400_RS20970	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D5400_RS20980	COG0450	alkyl hydroperoxide reductase
D5400_RS20990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D5400_RS21000	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D5400_RS21005	COG2226	methyltransferase
D5400_RS21010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D5400_RS21015	COG1024	Enoyl-CoA hydratase
D5400_RS21020	COG0268	Binds directly to 16S ribosomal RNA