locus-tag	class	description
WYH_RS00015	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WYH_RS00020	COG0271	Belongs to the BolA IbaG family
WYH_RS00030	COG0066	3-isopropylmalate dehydratase activity
WYH_RS00040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WYH_RS00055	COG2166	iron-sulfur cluster assembly
WYH_RS00095	COG1842	Phage shock protein A
WYH_RS00100	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WYH_RS00105	COG0779	Required for maturation of 30S ribosomal subunits
WYH_RS00115	COG2740	Nucleic-acid-binding protein implicated in transcription termination
WYH_RS00120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WYH_RS00130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WYH_RS00135	COG1435	thymidine kinase activity
WYH_RS00145	COG1994	Peptidase M50
WYH_RS00150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WYH_RS00155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WYH_RS00160	COG1185	polyribonucleotide nucleotidyltransferase activity
WYH_RS00185	COG2814	Major facilitator Superfamily
WYH_RS00190	COG0798	PFAM Bile acid sodium symporter
WYH_RS00205	COG2885	chlorophyll binding
WYH_RS00215	COG0842	Transport permease protein
WYH_RS00240	COG2936	dipeptidyl-peptidase activity
WYH_RS00250	COG4638	Rieske (2fe-2S)
WYH_RS00260	COG3384	dioxygenase
WYH_RS00275	COG2175	clavaminate synthase activity
WYH_RS00300	COG1335	isochorismatase
WYH_RS00305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WYH_RS00315	COG0300	oxidoreductase activity
WYH_RS00320	COG1335	isochorismatase
WYH_RS00340	COG0583	DNA-binding transcription factor activity
WYH_RS00355	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WYH_RS00360	COG0049	tRNA binding
WYH_RS00365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WYH_RS00370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WYH_RS00375	COG0051	transcription antitermination factor activity, RNA binding
WYH_RS00380	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WYH_RS00385	COG0088	Forms part of the polypeptide exit tunnel
WYH_RS00390	COG0089	rRNA binding
WYH_RS00395	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WYH_RS00400	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WYH_RS00405	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WYH_RS00410	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WYH_RS00415	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WYH_RS00420	COG0255	Belongs to the universal ribosomal protein uL29 family
WYH_RS00425	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WYH_RS00430	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WYH_RS00435	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WYH_RS00440	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WYH_RS00445	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WYH_RS00450	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WYH_RS00455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WYH_RS00460	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WYH_RS00465	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WYH_RS00470	COG1841	ribosomal large subunit assembly
WYH_RS00475	COG0200	Binds to the 23S rRNA
WYH_RS00480	COG0201	protein transport
WYH_RS00485	COG0563	adenylate kinase activity
WYH_RS00495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WYH_RS00500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WYH_RS00505	COG0202	RNA polymerase activity
WYH_RS00510	COG0203	ribosomal protein L17
WYH_RS00515	COG1505	serine-type exopeptidase activity
WYH_RS00530	COG2860	membrane
WYH_RS00545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WYH_RS00550	COG0508	dehydrogenase complex catalyzes the overall conversion of
WYH_RS00555	COG0567	Dehydrogenase, E1 component
WYH_RS00560	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WYH_RS00565	COG0039	L-malate dehydrogenase activity
WYH_RS00570	COG5001	Diguanylate cyclase
WYH_RS00590	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
WYH_RS00595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WYH_RS00625	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WYH_RS00630	COG0137	argininosuccinate synthase activity
WYH_RS00635	COG0534	Mate efflux family protein
WYH_RS00640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WYH_RS00645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WYH_RS00650	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WYH_RS00655	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
WYH_RS00685	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WYH_RS00690	COG1733	regulation of RNA biosynthetic process
WYH_RS00695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WYH_RS00715	COG2268	Band 7 protein
WYH_RS00735	COG0741	lytic transglycosylase activity
WYH_RS00740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WYH_RS00745	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WYH_RS00770	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WYH_RS00775	COG4106	trans-aconitate 2-methyltransferase activity
WYH_RS00780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WYH_RS00790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WYH_RS00795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WYH_RS00795	COG3153	acetyltransferase
WYH_RS00800	COG0538	isocitrate dehydrogenase activity
WYH_RS00815	COG4771	TonB-dependent receptor
WYH_RS00825	COG2244	polysaccharide biosynthetic process
WYH_RS00830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WYH_RS00890	COG0742	ribosomal rna small subunit methyltransferase
WYH_RS00895	COG1187	pseudouridine synthase activity
WYH_RS00905	COG0285	dihydrofolate synthase activity
WYH_RS00910	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WYH_RS00915	COG0159	tryptophan synthase activity
WYH_RS00920	COG0133	tryptophan synthase activity
WYH_RS00925	COG0135	phosphoribosylanthranilate isomerase activity
WYH_RS00930	COG0284	orotidine-5'-phosphate decarboxylase activity
WYH_RS00940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WYH_RS00960	COG2003	Belongs to the UPF0758 family
WYH_RS00985	COG0356	it plays a direct role in the translocation of protons across the membrane
WYH_RS00990	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WYH_RS00995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WYH_RS01000	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WYH_RS01005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WYH_RS01015	COG0539	negative regulation of cytoplasmic translation
WYH_RS01020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WYH_RS01030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WYH_RS01045	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WYH_RS01050	COG0228	four-way junction DNA binding
WYH_RS01055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WYH_RS01080	COG0336	Belongs to the RNA methyltransferase TrmD family
WYH_RS01085	COG0335	large ribosomal subunit rRNA binding
WYH_RS01100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WYH_RS01120	COG0189	ligase activity
WYH_RS01120	COG4067	protein conserved in archaea
WYH_RS01125	COG0189	ligase activity
WYH_RS01130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WYH_RS01135	COG0359	binds to the 23S rRNA
WYH_RS01140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WYH_RS01145	COG0360	Binds together with S18 to 16S ribosomal RNA
WYH_RS01150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WYH_RS01175	COG0493	'glutamate synthase
WYH_RS01180	COG5001	Diguanylate cyclase
WYH_RS01180	COG3300	MHYT domain
WYH_RS01185	COG3300	MHYT domain
WYH_RS01185	COG5001	Diguanylate cyclase
WYH_RS01190	COG0481	GTPase activity
WYH_RS01220	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WYH_RS01240	COG0497	DNA recombination
WYH_RS01255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WYH_RS01265	COG2264	protein methyltransferase activity
WYH_RS01275	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_RS01285	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WYH_RS01295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WYH_RS01300	COG1959	2 iron, 2 sulfur cluster binding
WYH_RS01335	COG2321	neutral zinc metallopeptidase
WYH_RS01340	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_RS01355	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WYH_RS01365	COG1051	belongs to the nudix hydrolase family
WYH_RS01370	COG0674	pyruvate-flavodoxin oxidoreductase activity
WYH_RS01370	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WYH_RS01375	COG1013	pyruvate-flavodoxin oxidoreductase activity
WYH_RS01385	COG0415	Belongs to the DNA photolyase family
WYH_RS01390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WYH_RS01400	COG4221	oxidoreductase activity
WYH_RS01405	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WYH_RS01420	COG1596	polysaccharide export
WYH_RS01465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WYH_RS01505	COG2801	Transposase and inactivated derivatives
WYH_RS01505	COG3415	Transposase
WYH_RS01535	COG0346	lactoylglutathione lyase activity
WYH_RS01540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WYH_RS01545	COG4771	TonB-dependent receptor
WYH_RS01575	COG2814	Major facilitator Superfamily
WYH_RS01605	COG2814	Major facilitator Superfamily
WYH_RS01615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WYH_RS01630	COG4771	TonB-dependent receptor
WYH_RS01660	COG4771	TonB-dependent receptor
WYH_RS01665	COG1609	Transcriptional regulator
WYH_RS01675	COG0657	acetylesterase activity
WYH_RS01695	COG1940	carbohydrate kinase activity
WYH_RS01730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WYH_RS01750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WYH_RS01760	COG0126	phosphoglycerate kinase activity
WYH_RS01765	COG3588	fructose-bisphosphate aldolase
WYH_RS01775	COG0352	thiamine-phosphate diphosphorylase activity
WYH_RS01785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WYH_RS01790	COG0483	inositol monophosphate 1-phosphatase activity
WYH_RS01800	COG3273	potassium ion transport
WYH_RS01800	COG0471	metal ion transport
WYH_RS01810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WYH_RS01815	COG4191	Histidine kinase
WYH_RS01820	COG2204	response regulator
WYH_RS01835	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WYH_RS01840	COG0733	neurotransmitter:sodium symporter activity
WYH_RS01855	COG0745	RESPONSE REGULATOR receiver
WYH_RS01860	COG0704	Plays a role in the regulation of phosphate uptake
WYH_RS01865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WYH_RS01875	COG0573	inorganic phosphate transmembrane transporter activity
WYH_RS01885	COG3746	phosphate-selective porin O and P
WYH_RS01890	COG5002	protein histidine kinase activity
WYH_RS01905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WYH_RS01920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WYH_RS01925	COG2353	YceI-like domain
WYH_RS01930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WYH_RS01940	COG0028	Belongs to the TPP enzyme family
WYH_RS01945	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WYH_RS01950	COG0560	Phosphoserine phosphatase
WYH_RS01955	COG2311	Membrane
WYH_RS01960	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WYH_RS01965	COG1722	exodeoxyribonuclease VII activity
WYH_RS01970	COG0142	geranyltranstransferase activity
WYH_RS01975	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WYH_RS01985	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WYH_RS01990	COG0662	Cupin 2, conserved barrel domain protein
WYH_RS01995	COG1131	(ABC) transporter
WYH_RS02000	COG0842	Transport permease protein
WYH_RS02010	COG0343	queuine tRNA-ribosyltransferase activity
WYH_RS02015	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WYH_RS02030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WYH_RS02035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WYH_RS02040	COG0698	ribose 5-phosphate isomerase
WYH_RS02055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WYH_RS02065	COG1610	YqeY-like protein
WYH_RS02070	COG0505	Belongs to the CarA family
WYH_RS02085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WYH_RS02115	COG0148	phosphopyruvate hydratase activity
WYH_RS02120	COG0667	Aldo Keto reductase
WYH_RS02125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WYH_RS02130	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WYH_RS02130	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WYH_RS02135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WYH_RS02150	COG1304	FMN binding
WYH_RS02175	COG4206	TonB-dependent receptor
WYH_RS02180	COG0477	Major facilitator Superfamily
WYH_RS02185	COG1802	Transcriptional regulator
WYH_RS02190	COG4206	TonB-dependent receptor
WYH_RS02190	COG4206	TonB-dependent receptor
WYH_RS02245	COG0028	Belongs to the TPP enzyme family
WYH_RS02290	COG4771	TonB-dependent receptor
WYH_RS02315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WYH_RS02320	COG0508	dehydrogenase complex catalyzes the overall conversion of
WYH_RS02320	COG0022	dehydrogenase e1 component
WYH_RS02350	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
WYH_RS02360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WYH_RS02375	COG0012	GTP binding
WYH_RS02385	COG0193	aminoacyl-tRNA hydrolase activity
WYH_RS02390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WYH_RS02405	COG0752	glycyl-tRNA synthetase alpha subunit
WYH_RS02410	COG0751	glycine-tRNA ligase activity
WYH_RS02415	COG0574	Belongs to the PEP-utilizing enzyme family
WYH_RS02415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WYH_RS02425	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WYH_RS02430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WYH_RS02435	COG1960	acyl-CoA dehydrogenase activity
WYH_RS02465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WYH_RS02475	COG3876	Protein conserved in bacteria
WYH_RS02480	COG0006	proline dipeptidase activity
WYH_RS02500	COG0187	DNA topoisomerase II activity
WYH_RS02510	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WYH_RS02515	COG0792	nuclease activity
WYH_RS02520	COG0189	ligase activity
WYH_RS02525	COG0586	Pfam SNARE associated Golgi protein
WYH_RS02530	COG4974	Belongs to the 'phage' integrase family
WYH_RS02535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WYH_RS02540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WYH_RS02545	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
WYH_RS02550	COG1420	regulation of RNA biosynthetic process
WYH_RS02555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WYH_RS02575	COG0443	Heat shock 70 kDa protein
WYH_RS02580	COG0484	heat shock protein binding
WYH_RS02605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WYH_RS02615	COG0442	prolyl-tRNA aminoacylation
WYH_RS02620	COG0557	exoribonuclease II activity
WYH_RS02630	COG0508	dehydrogenase complex catalyzes the overall conversion of
WYH_RS02640	COG1607	acyl-coa hydrolase
WYH_RS02645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WYH_RS02650	COG0427	acetyl-CoA hydrolase
WYH_RS02665	COG2951	lytic endotransglycosylase activity
WYH_RS02675	COG1686	Belongs to the peptidase S11 family
WYH_RS02680	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WYH_RS02695	COG0084	hydrolase, TatD family'
WYH_RS02700	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
WYH_RS02700	COG0321	lipoyl(octanoyl) transferase activity
WYH_RS02705	COG3956	TIGRFAM MazG family protein
WYH_RS02710	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WYH_RS02715	COG1923	regulation of RNA biosynthetic process
WYH_RS02720	COG2204	response regulator
WYH_RS02725	COG5000	phosphorelay sensor kinase activity
WYH_RS02730	COG2204	response regulator
WYH_RS02735	COG3852	Histidine kinase
WYH_RS02745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WYH_RS02745	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WYH_RS02750	COG1546	Belongs to the CinA family
WYH_RS02755	COG2867	negative regulation of translational initiation
WYH_RS02760	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WYH_RS02765	COG0288	reversible hydration of carbon dioxide
WYH_RS02790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WYH_RS02815	COG0772	Belongs to the SEDS family
WYH_RS02840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WYH_RS02845	COG4637	Psort location Cytoplasmic, score
WYH_RS02875	COG0210	DNA helicase
WYH_RS02885	COG0358	DNA primase activity
WYH_RS02895	COG4974	Belongs to the 'phage' integrase family
WYH_RS02920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WYH_RS02925	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WYH_RS02930	COG0071	Belongs to the small heat shock protein (HSP20) family
WYH_RS02935	COG0504	CTP synthase activity
WYH_RS02945	COG0149	triose-phosphate isomerase activity
WYH_RS02955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WYH_RS02965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WYH_RS02970	COG0134	indole-3-glycerol-phosphate synthase activity
WYH_RS02980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WYH_RS02985	COG0315	cyclic pyranopterin monophosphate synthase activity
WYH_RS02990	COG0303	'Molybdopterin
WYH_RS02995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WYH_RS03000	COG0658	competence protein
WYH_RS03000	COG2333	competence protein COMEC
WYH_RS03005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WYH_RS03020	COG2205	protein histidine kinase activity
WYH_RS03055	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
WYH_RS03060	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WYH_RS03060	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WYH_RS03065	COG1007	ATP synthesis coupled electron transport
WYH_RS03080	COG0713	ATP synthesis coupled electron transport
WYH_RS03090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WYH_RS03095	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WYH_RS03100	COG1034	ATP synthesis coupled electron transport
WYH_RS03110	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WYH_RS03115	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WYH_RS03120	COG0649	NAD binding
WYH_RS03125	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WYH_RS03130	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WYH_RS03135	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WYH_RS03140	COG0183	Belongs to the thiolase family
WYH_RS03160	COG2226	methyltransferase
WYH_RS03170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WYH_RS03175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WYH_RS03180	COG0860	N-Acetylmuramoyl-L-alanine amidase
WYH_RS03185	COG1530	ribonuclease E activity
WYH_RS03195	COG2226	methyltransferase
WYH_RS03205	COG1181	Belongs to the D-alanine--D-alanine ligase family
WYH_RS03220	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WYH_RS03250	COG3409	Peptidoglycan-binding domain 1 protein
WYH_RS03250	COG3267	Type II secretory pathway component ExeA
WYH_RS03305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WYH_RS03310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WYH_RS03310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WYH_RS03320	COG0129	dihydroxy-acid dehydratase activity
WYH_RS03330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WYH_RS03370	COG2885	chlorophyll binding
WYH_RS03370	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
WYH_RS03390	COG1136	(ABC) transporter
WYH_RS03400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WYH_RS03410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WYH_RS03420	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WYH_RS03440	COG0477	Major facilitator Superfamily
WYH_RS03440	COG2814	Major facilitator Superfamily
WYH_RS03450	COG0653	protein targeting
WYH_RS03460	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
WYH_RS03465	COG0483	inositol monophosphate 1-phosphatase activity
WYH_RS03475	COG1074	ATP-dependent DNA helicase activity
WYH_RS03485	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WYH_RS03490	COG3178	'Phosphotransferase
WYH_RS03495	COG0802	atpase or kinase
WYH_RS03500	COG2205	protein histidine kinase activity
WYH_RS03505	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WYH_RS03510	COG0678	peroxiredoxin activity
WYH_RS03510	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WYH_RS03520	COG0302	gtp cyclohydrolase
WYH_RS03525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WYH_RS03540	COG0494	nUDIX hydrolase
WYH_RS03555	COG0825	malonyl-CoA metabolic process
WYH_RS03560	COG4974	Belongs to the 'phage' integrase family
WYH_RS03570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WYH_RS03575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WYH_RS03595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WYH_RS03605	COG0513	Belongs to the DEAD box helicase family
WYH_RS03620	COG0166	Belongs to the GPI family
WYH_RS03625	COG0681	Belongs to the peptidase S26 family
WYH_RS03630	COG0571	ribonuclease III activity
WYH_RS03635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WYH_RS03640	COG2814	Major facilitator Superfamily
WYH_RS03650	COG1754	DNA topoisomerase type I activity
WYH_RS03650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WYH_RS03655	COG0758	DNA mediated transformation
WYH_RS03660	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WYH_RS03665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WYH_RS03670	COG0156	8-amino-7-oxononanoate synthase activity
WYH_RS03715	COG1748	Saccharopine dehydrogenase
WYH_RS03725	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
WYH_RS03730	COG3387	PFAM Glycoside hydrolase 15-related
WYH_RS03735	COG1877	trehalose-phosphatase activity
WYH_RS03755	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WYH_RS03795	COG0842	Transport permease protein
WYH_RS03800	COG0842	Transport permease protein
WYH_RS03800	COG1129	ABC transporter
WYH_RS03805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WYH_RS03810	COG1538	Outer membrane efflux protein
WYH_RS03830	COG3243	poly(R)-hydroxyalkanoic acid synthase
WYH_RS03840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WYH_RS03845	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WYH_RS03890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WYH_RS03920	COG0741	lytic transglycosylase activity
WYH_RS03920	COG1196	nuclear chromosome segregation
WYH_RS03920	COG0739	heme binding
WYH_RS03925	COG0582	viral genome integration into host DNA
WYH_RS03935	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WYH_RS03940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WYH_RS03945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WYH_RS03950	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WYH_RS03955	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WYH_RS03960	COG0583	DNA-binding transcription factor activity
WYH_RS03965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WYH_RS03990	COG5001	Diguanylate cyclase
WYH_RS03990	COG3300	MHYT domain
WYH_RS03995	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WYH_RS04000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WYH_RS04005	COG0552	protein localization to endoplasmic reticulum
WYH_RS04010	COG2917	probably involved in intracellular septation
WYH_RS04020	COG3158	transport of potassium into the cell
WYH_RS04030	COG3088	subunit of a heme lyase
WYH_RS04035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WYH_RS04040	COG1138	Cytochrome C-type biogenesis protein
WYH_RS04045	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WYH_RS04050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WYH_RS04075	COG0254	rRNA binding
WYH_RS04080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WYH_RS04095	COG0750	zinc metalloprotease
WYH_RS04100	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WYH_RS04110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WYH_RS04115	COG0233	cytoplasmic translational termination
WYH_RS04120	COG0528	UMP kinase activity
WYH_RS04125	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WYH_RS04130	COG0052	Belongs to the universal ribosomal protein uS2 family
WYH_RS04145	COG0688	phosphatidylethanolamine metabolic process
WYH_RS04165	COG0535	radical SAM domain protein
WYH_RS04210	COG0582	viral genome integration into host DNA
WYH_RS04220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WYH_RS04245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WYH_RS04260	COG1643	Atp-dependent helicase
WYH_RS04270	COG0142	geranyltranstransferase activity
WYH_RS04275	COG1605	Chorismate mutase
WYH_RS04275	COG0287	Prephenate dehydrogenase
WYH_RS04305	COG0488	(ABC) transporter
WYH_RS04315	COG0438	transferase activity, transferring glycosyl groups
WYH_RS04325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WYH_RS04330	COG1862	Preprotein translocase
WYH_RS04345	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WYH_RS04350	COG0511	ligase activity, forming carbon-carbon bonds
WYH_RS04355	COG0439	Biotin carboxylase
WYH_RS04365	COG1522	sequence-specific DNA binding
WYH_RS04370	COG2205	protein histidine kinase activity
WYH_RS04395	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
WYH_RS04400	COG1301	dicarboxylic acid transport
WYH_RS04415	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
WYH_RS04420	COG4948	Mandelate Racemase Muconate Lactonizing
WYH_RS04435	COG4771	TonB-dependent receptor
WYH_RS04445	COG1609	Transcriptional regulator
WYH_RS04475	COG2079	MmgE PrpD family protein
WYH_RS04515	COG1254	Belongs to the acylphosphatase family
WYH_RS04535	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WYH_RS04560	COG0402	S-adenosylhomocysteine deaminase activity
WYH_RS04570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WYH_RS04570	COG1199	ATP-dependent helicase activity
WYH_RS04585	COG0776	regulation of translation
WYH_RS04590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WYH_RS04595	COG0416	fatty acid biosynthetic process
WYH_RS04600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WYH_RS04620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WYH_RS04625	COG0215	cysteine-tRNA ligase activity
WYH_RS04635	COG1346	cytolysis
WYH_RS04650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WYH_RS04680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WYH_RS04685	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WYH_RS04690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WYH_RS04695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WYH_RS04700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WYH_RS04745	COG0357	Ribosomal RNA small subunit methyltransferase G
WYH_RS04755	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WYH_RS04805	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WYH_RS04815	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WYH_RS04820	COG2133	pyrroloquinoline quinone binding
WYH_RS04840	COG0617	tRNA 3'-terminal CCA addition
WYH_RS04850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WYH_RS04855	COG0693	protein deglycase activity
WYH_RS04865	COG1104	cysteine desulfurase activity
WYH_RS04870	COG1104	cysteine desulfurase activity
WYH_RS04875	COG2945	thiolester hydrolase activity
WYH_RS04905	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
WYH_RS04910	COG0745	RESPONSE REGULATOR receiver
WYH_RS04915	COG0642	Histidine kinase
WYH_RS04925	COG1660	Displays ATPase and GTPase activities
WYH_RS04930	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
WYH_RS04930	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WYH_RS04940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WYH_RS04950	COG1322	Protein conserved in bacteria
WYH_RS04955	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WYH_RS04960	COG1295	ribonuclease BN
WYH_RS04970	COG0242	peptide deformylase activity
WYH_RS04975	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WYH_RS04980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WYH_RS04990	COG0101	tRNA pseudouridine synthase activity
WYH_RS04995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WYH_RS05005	COG1733	regulation of RNA biosynthetic process
WYH_RS05010	COG0625	glutathione transferase activity
WYH_RS05015	COG5507	3-demethylubiquinone-9 3-methyltransferase
WYH_RS05035	COG1741	Belongs to the pirin family
WYH_RS05050	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WYH_RS05055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WYH_RS05060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WYH_RS05070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WYH_RS05075	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
WYH_RS05095	COG0322	excinuclease ABC activity
WYH_RS05100	COG2081	HI0933 family
WYH_RS05110	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WYH_RS05115	COG0424	maF-like protein
WYH_RS05135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WYH_RS05145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WYH_RS05170	COG2814	Major facilitator Superfamily
WYH_RS05180	COG1968	undecaprenyl-diphosphatase activity
WYH_RS05185	COG4771	TonB-dependent receptor
WYH_RS05195	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WYH_RS05200	COG0612	Peptidase, M16
WYH_RS05205	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WYH_RS05210	COG0047	phosphoribosylformylglycinamidine synthase activity
WYH_RS05215	COG5001	Diguanylate cyclase
WYH_RS05225	COG2212	antiporter activity
WYH_RS05235	COG0651	ATP synthesis coupled electron transport
WYH_RS05240	COG1006	Multisubunit Na H antiporter MnhC subunit
WYH_RS05245	COG2111	Na H antiporter
WYH_RS05245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WYH_RS05255	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
WYH_RS05265	COG2989	Protein conserved in bacteria
WYH_RS05280	COG1136	(ABC) transporter
WYH_RS05285	COG0071	Belongs to the small heat shock protein (HSP20) family
WYH_RS05325	COG4771	TonB-dependent receptor
WYH_RS05330	COG5001	Diguanylate cyclase
WYH_RS05340	COG3836	Belongs to the HpcH HpaI aldolase family
WYH_RS05345	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WYH_RS05350	COG1454	alcohol dehydrogenase
WYH_RS05355	COG2814	Major facilitator Superfamily
WYH_RS05360	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_RS05375	COG1012	belongs to the aldehyde dehydrogenase family
WYH_RS05380	COG3246	L-lysine catabolic process to acetate
WYH_RS05410	COG4771	TonB-dependent receptor
WYH_RS05465	COG2132	Multicopper oxidase
WYH_RS05470	COG1937	Protein conserved in bacteria
WYH_RS05475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WYH_RS05480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WYH_RS05485	COG0546	phosphoglycolate phosphatase activity
WYH_RS05495	COG1045	serine acetyltransferase
WYH_RS05500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WYH_RS05510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WYH_RS05515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WYH_RS05525	COG0105	UTP biosynthetic process
WYH_RS05540	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WYH_RS05550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WYH_RS05555	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WYH_RS05560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WYH_RS05570	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WYH_RS05585	COG3724	N-succinylarginine dihydrolase activity
WYH_RS05595	COG1970	mechanosensitive ion channel activity
WYH_RS05620	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WYH_RS05635	COG0572	uridine kinase
WYH_RS05645	COG4993	Dehydrogenase
WYH_RS05655	COG2010	Cytochrome c
WYH_RS05675	COG4993	Dehydrogenase
WYH_RS05705	COG4993	Dehydrogenase
WYH_RS05720	COG2967	ApaG domain
WYH_RS05725	COG3920	Histidine kinase
WYH_RS05755	COG0473	3-isopropylmalate dehydrogenase activity
WYH_RS05760	COG1381	Involved in DNA repair and RecF pathway recombination
WYH_RS05780	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
WYH_RS05790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WYH_RS05820	COG0435	Glutathione S-transferase
WYH_RS05825	COG0625	glutathione transferase activity
WYH_RS05850	COG2801	Transposase and inactivated derivatives
WYH_RS05850	COG3415	Transposase
WYH_RS05880	COG1012	belongs to the aldehyde dehydrogenase family
WYH_RS05900	COG2814	Major facilitator Superfamily
WYH_RS05920	COG1477	protein flavinylation
WYH_RS05925	COG3128	pkhd-type hydroxylase
WYH_RS05930	COG4774	siderophore transport
WYH_RS05955	COG3119	arylsulfatase activity
WYH_RS05960	COG4771	TonB-dependent receptor
WYH_RS05970	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
WYH_RS05975	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WYH_RS05980	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
WYH_RS05985	COG0612	Peptidase, M16
WYH_RS05990	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WYH_RS05995	COG0778	Nitroreductase
WYH_RS06005	COG0456	acetyltransferase
WYH_RS06025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WYH_RS06045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WYH_RS06050	COG1253	flavin adenine dinucleotide binding
WYH_RS06055	COG0583	DNA-binding transcription factor activity
WYH_RS06070	COG2239	Acts as a magnesium transporter
WYH_RS06095	COG2816	NAD+ diphosphatase activity
WYH_RS06110	COG1194	a g-specific adenine glycosylase
WYH_RS06130	COG1196	nuclear chromosome segregation
WYH_RS06135	COG0789	Transcriptional regulator
WYH_RS06160	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WYH_RS06190	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WYH_RS06195	COG1012	belongs to the aldehyde dehydrogenase family
WYH_RS06215	COG0418	dihydroorotase activity
WYH_RS06225	COG0354	folic acid binding
WYH_RS06240	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WYH_RS06245	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WYH_RS06255	COG0314	molybdopterin synthase activity
WYH_RS06265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WYH_RS06305	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WYH_RS06310	COG0109	protoheme IX farnesyltransferase activity
WYH_RS06315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WYH_RS06325	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WYH_RS06330	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WYH_RS06335	COG0736	holo-[acyl-carrier-protein] synthase activity
WYH_RS06340	COG0681	Belongs to the peptidase S26 family
WYH_RS06345	COG0628	permease
WYH_RS06355	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WYH_RS06360	COG1648	precorrin-2 dehydrogenase activity
WYH_RS06360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WYH_RS06365	COG0019	diaminopimelate decarboxylase activity
WYH_RS06375	COG0165	Argininosuccinate lyase
WYH_RS06380	COG3118	belongs to the thioredoxin family
WYH_RS06425	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WYH_RS06430	COG2755	lipolytic protein G-D-S-L family
WYH_RS06435	COG4181	ATPase activity
WYH_RS06445	COG4771	TonB-dependent receptor
WYH_RS06450	COG0297	glycogen (starch) synthase activity
WYH_RS06460	COG1695	Transcriptional regulator
WYH_RS06465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WYH_RS06485	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WYH_RS06495	COG2897	thiosulfate sulfurtransferase activity
WYH_RS06500	COG0626	cystathionine gamma-synthase activity
WYH_RS06505	COG0668	transmembrane transport
WYH_RS06510	COG1648	precorrin-2 dehydrogenase activity
WYH_RS06510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WYH_RS06520	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WYH_RS06530	COG0175	sulfate reduction
WYH_RS06540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
WYH_RS06545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WYH_RS06560	COG0670	Belongs to the BI1 family
WYH_RS06565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WYH_RS06585	COG0849	cell division
WYH_RS06590	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WYH_RS06595	COG1181	Belongs to the D-alanine--D-alanine ligase family
WYH_RS06600	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WYH_RS06605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WYH_RS06610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WYH_RS06620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WYH_RS06625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WYH_RS06630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WYH_RS06635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WYH_RS06650	COG0275	rRNA processing
WYH_RS06655	COG2001	Belongs to the MraZ family
WYH_RS06670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WYH_RS06690	COG2154	pterin-4-alpha-carbinolamine dehydratase
WYH_RS06695	COG4133	protoheme IX ABC transporter activity
WYH_RS06700	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WYH_RS06710	COG0457	Tetratricopeptide repeat
WYH_RS06725	COG0024	Methionine aminopeptidase
WYH_RS06735	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WYH_RS06755	COG0174	glutamine synthetase
WYH_RS06770	COG0729	surface antigen
WYH_RS06775	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WYH_RS06780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WYH_RS06785	COG2084	Dehydrogenase
WYH_RS06790	COG1574	metal-dependent hydrolase with the TIM-barrel fold
WYH_RS06800	COG0805	protein transport
WYH_RS06805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WYH_RS06810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WYH_RS06815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WYH_RS06820	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
WYH_RS06825	COG1472	Belongs to the glycosyl hydrolase 3 family
WYH_RS06840	COG0018	arginyl-trna synthetase
WYH_RS06850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WYH_RS06855	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WYH_RS06860	COG0328	RNA-DNA hybrid ribonuclease activity
WYH_RS06865	COG0670	Belongs to the BI1 family
WYH_RS06870	COG0583	DNA-binding transcription factor activity
WYH_RS06885	COG3422	double-strand break repair
WYH_RS06910	COG4964	Belongs to the GSP D family
WYH_RS06940	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
WYH_RS06955	COG0457	Tetratricopeptide repeat
WYH_RS06970	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WYH_RS06980	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WYH_RS06985	COG0154	amidase activity
WYH_RS06990	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WYH_RS07005	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WYH_RS07010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WYH_RS07020	COG0546	phosphoglycolate phosphatase activity
WYH_RS07050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WYH_RS07055	COG0525	valine-tRNA ligase activity
WYH_RS07065	COG0534	Mate efflux family protein
WYH_RS07070	COG0784	Response regulator, receiver
WYH_RS07085	COG0730	response to heat
WYH_RS07100	COG1215	transferase activity, transferring glycosyl groups
WYH_RS07115	COG0544	peptidyl-prolyl cis-trans isomerase activity
WYH_RS07125	COG0154	amidase activity
WYH_RS07130	COG2814	Major facilitator Superfamily
WYH_RS07140	COG4771	TonB-dependent receptor
WYH_RS07145	COG1309	transcriptional regulator
WYH_RS07150	COG1846	Transcriptional regulator
WYH_RS07160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WYH_RS07165	COG1902	pentaerythritol trinitrate reductase activity
WYH_RS07170	COG0488	(ABC) transporter
WYH_RS07185	COG0740	serine-type endopeptidase activity
WYH_RS07190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WYH_RS07210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WYH_RS07215	COG0564	pseudouridine synthase activity
WYH_RS07230	COG3023	N-Acetylmuramoyl-L-alanine amidase
WYH_RS07255	COG1160	GTP binding
WYH_RS07265	COG2193	ferroxidase activity
WYH_RS07275	COG2311	Membrane
WYH_RS07300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WYH_RS07305	COG0540	Belongs to the ATCase OTCase family
WYH_RS07310	COG0616	signal peptide processing
WYH_RS07340	COG1058	Belongs to the CinA family
WYH_RS07340	COG1546	Belongs to the CinA family
WYH_RS07345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WYH_RS07350	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
WYH_RS07355	COG2080	2 iron, 2 sulfur cluster binding
WYH_RS07360	COG3665	Urea carboxylase-associated protein
WYH_RS07395	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WYH_RS07400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WYH_RS07420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WYH_RS07425	COG4771	TonB-dependent receptor
WYH_RS07440	COG0432	Pfam Uncharacterised protein family UPF0047
WYH_RS07450	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
WYH_RS07455	COG0129	dihydroxy-acid dehydratase activity
WYH_RS07460	COG0837	glucose binding
WYH_RS07465	COG0800	Aldolase
WYH_RS07480	COG0037	tRNA processing
WYH_RS07545	COG0321	lipoyl(octanoyl) transferase activity
WYH_RS07565	COG2080	2 iron, 2 sulfur cluster binding
WYH_RS07570	COG0235	Class ii aldolase
WYH_RS07580	COG2271	Major facilitator Superfamily
WYH_RS07585	COG2207	Transcriptional regulator
WYH_RS07590	COG4771	TonB-dependent receptor
WYH_RS07605	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_RS07615	COG1063	alcohol dehydrogenase
WYH_RS07625	COG0784	Response regulator, receiver
WYH_RS07655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WYH_RS07665	COG3243	poly(R)-hydroxyalkanoic acid synthase
WYH_RS07670	COG0436	Aminotransferase
WYH_RS07675	COG2271	Major facilitator Superfamily
WYH_RS07680	COG0129	dihydroxy-acid dehydratase activity
WYH_RS07705	COG0445	tRNA wobble uridine modification
WYH_RS07750	COG0577	efflux transmembrane transporter activity
WYH_RS07750	COG1136	(ABC) transporter
WYH_RS07755	COG0577	efflux transmembrane transporter activity
WYH_RS07755	COG1136	(ABC) transporter
WYH_RS07765	COG0577	efflux transmembrane transporter activity
WYH_RS07765	COG1136	(ABC) transporter
WYH_RS07765	COG0577	efflux transmembrane transporter activity
WYH_RS07765	COG1136	(ABC) transporter
WYH_RS07770	COG0577	efflux transmembrane transporter activity
WYH_RS07770	COG1136	(ABC) transporter
WYH_RS07785	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
WYH_RS07790	COG4149	molybdate abc transporter
WYH_RS07795	COG0725	ABC transporter, periplasmic molybdate-binding protein
WYH_RS07800	COG3920	Histidine kinase
WYH_RS07825	COG2175	clavaminate synthase activity
WYH_RS07830	COG0402	S-adenosylhomocysteine deaminase activity
WYH_RS07840	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WYH_RS07850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WYH_RS07860	COG0351	phosphomethylpyrimidine kinase
WYH_RS07860	COG0352	thiamine-phosphate diphosphorylase activity
WYH_RS07860	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WYH_RS07875	COG1054	Belongs to the UPF0176 family
WYH_RS07880	COG0513	Belongs to the DEAD box helicase family
WYH_RS07895	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WYH_RS07905	COG0077	Prephenate dehydratase
WYH_RS07920	COG0714	Associated with various cellular activities
WYH_RS07940	COG0454	-acetyltransferase
WYH_RS07960	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WYH_RS07980	COG2989	Protein conserved in bacteria
WYH_RS07990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WYH_RS08000	COG2255	four-way junction helicase activity
WYH_RS08005	COG0632	four-way junction helicase activity
WYH_RS08010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WYH_RS08015	COG0450	alkyl hydroperoxide reductase
WYH_RS08040	COG4395	Tim44
WYH_RS08045	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WYH_RS08050	COG0728	peptidoglycan biosynthetic process
WYH_RS08055	COG0180	Tryptophanyl-tRNA synthetase
WYH_RS08065	COG0756	dUTP diphosphatase activity
WYH_RS08070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WYH_RS08080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WYH_RS08085	COG2226	methyltransferase
WYH_RS08095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WYH_RS08100	COG0268	Binds directly to 16S ribosomal RNA
WYH_RS08110	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WYH_RS08120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WYH_RS08125	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
WYH_RS08130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WYH_RS08145	COG1301	dicarboxylic acid transport
WYH_RS08150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WYH_RS08155	COG0625	glutathione transferase activity
WYH_RS08175	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WYH_RS08180	COG0706	membrane insertase activity
WYH_RS08185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
WYH_RS08190	COG0594	ribonuclease P activity
WYH_RS08200	COG0606	chelatase, subunit chli
WYH_RS08205	COG4993	Dehydrogenase
WYH_RS08215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WYH_RS08220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WYH_RS08220	COG2010	Cytochrome c
WYH_RS08235	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
WYH_RS08240	COG1742	UPF0060 membrane protein
WYH_RS08265	COG0753	catalase activity
WYH_RS08300	COG1764	response to oxidative stress
WYH_RS08305	COG1846	Transcriptional regulator
WYH_RS08345	COG0668	transmembrane transport
WYH_RS08350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WYH_RS08375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WYH_RS08420	COG0606	chelatase, subunit chli
WYH_RS08435	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WYH_RS08450	COG2866	Carboxypeptidase
WYH_RS08465	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
WYH_RS08475	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WYH_RS08480	COG0295	cytidine deaminase activity
WYH_RS08490	COG5328	Belongs to the UPF0262 family
WYH_RS08495	COG0305	Participates in initiation and elongation during chromosome replication
WYH_RS08510	COG1758	RNA polymerase activity
WYH_RS08560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WYH_RS08565	COG0730	response to heat
WYH_RS08575	COG1482	cell wall glycoprotein biosynthetic process
WYH_RS08610	COG1132	(ABC) transporter
WYH_RS08620	COG1596	polysaccharide export
WYH_RS08625	COG0463	Glycosyl transferase, family 2
WYH_RS08630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WYH_RS08665	COG1215	transferase activity, transferring glycosyl groups
WYH_RS08670	COG0438	transferase activity, transferring glycosyl groups
WYH_RS08675	COG1215	transferase activity, transferring glycosyl groups
WYH_RS08685	COG3206	protein involved in exopolysaccharide biosynthesis
WYH_RS08685	COG0489	protein tyrosine kinase activity
WYH_RS08735	COG2273	Hydrolase Family 16
WYH_RS08740	COG0730	response to heat
WYH_RS08745	COG3453	Protein conserved in bacteria
WYH_RS08745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WYH_RS08755	COG0450	alkyl hydroperoxide reductase
WYH_RS08760	COG0640	Transcriptional regulator
WYH_RS08765	COG3118	belongs to the thioredoxin family
WYH_RS08780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WYH_RS08785	COG0446	pyridine nucleotide-disulphide oxidoreductase
WYH_RS08800	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WYH_RS08805	COG4988	ABC transporter
WYH_RS08810	COG1271	oxidase subunit
WYH_RS08815	COG1294	oxidase, subunit
WYH_RS08820	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
WYH_RS08825	COG4771	TonB-dependent receptor
WYH_RS08840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
WYH_RS08875	COG0438	transferase activity, transferring glycosyl groups
WYH_RS08880	COG0438	transferase activity, transferring glycosyl groups
WYH_RS08890	COG0489	protein tyrosine kinase activity
WYH_RS08895	COG2197	response regulator
WYH_RS08900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WYH_RS08905	COG0022	dehydrogenase e1 component
WYH_RS08935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WYH_RS08940	COG1086	Polysaccharide biosynthesis protein
WYH_RS08950	COG0438	transferase activity, transferring glycosyl groups
WYH_RS08960	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
WYH_RS08965	COG2197	response regulator
WYH_RS08970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WYH_RS09000	COG1309	transcriptional regulator
WYH_RS09010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WYH_RS09020	COG4206	TonB-dependent receptor
WYH_RS09075	COG0300	oxidoreductase activity
WYH_RS09095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WYH_RS09100	COG0179	Fumarylacetoacetate (FAA) hydrolase
WYH_RS09130	COG1012	belongs to the aldehyde dehydrogenase family
WYH_RS09140	COG3971	2-oxopent-4-enoate hydratase activity
WYH_RS09160	COG0583	DNA-binding transcription factor activity
WYH_RS09180	COG4771	TonB-dependent receptor
WYH_RS09190	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_RS09205	COG0583	DNA-binding transcription factor activity
WYH_RS09250	COG3485	protocatechuate 3,4-dioxygenase
WYH_RS09265	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WYH_RS09275	COG1414	Transcriptional regulator
WYH_RS09295	COG2197	response regulator
WYH_RS09325	COG3415	Transposase
WYH_RS09325	COG2801	Transposase and inactivated derivatives
WYH_RS09330	COG0582	viral genome integration into host DNA
WYH_RS09345	COG2133	pyrroloquinoline quinone binding
WYH_RS09355	COG1217	gtp-binding protein TYPA
WYH_RS09365	COG3618	amidohydrolase
WYH_RS09375	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WYH_RS09385	COG2159	amidohydrolase
WYH_RS09430	COG0456	acetyltransferase
WYH_RS09455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WYH_RS09465	COG1012	belongs to the aldehyde dehydrogenase family
WYH_RS09475	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_RS09490	COG2175	clavaminate synthase activity
WYH_RS09500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WYH_RS09515	COG2119	membrane
WYH_RS09525	COG1012	belongs to the aldehyde dehydrogenase family
WYH_RS09540	COG0527	aspartate kinase activity
WYH_RS09545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WYH_RS09550	COG3781	membrane
WYH_RS09555	COG2375	cellular response to nickel ion
WYH_RS09560	COG1393	Belongs to the ArsC family
WYH_RS09570	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WYH_RS09575	COG0217	transcriptional regulatory protein
WYH_RS09585	COG0393	Putative heavy-metal-binding
WYH_RS09590	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_RS09595	COG3750	Belongs to the UPF0335 family
WYH_RS09605	COG0469	pyruvate kinase activity
WYH_RS09610	COG4974	Belongs to the 'phage' integrase family
WYH_RS09695	COG3451	type IV secretory pathway VirB4
WYH_RS09710	COG4962	Type ii secretion system protein e
WYH_RS09720	COG3668	Plasmid stabilization system
WYH_RS09800	COG0741	lytic transglycosylase activity
WYH_RS09805	COG0741	lytic transglycosylase activity
WYH_RS09810	COG0741	lytic transglycosylase activity
WYH_RS09865	COG5489	Protein of unknown function (DUF736)
WYH_RS09880	COG1742	UPF0060 membrane protein
WYH_RS09895	COG3118	belongs to the thioredoxin family
WYH_RS09905	COG2095	MarC family integral membrane protein
WYH_RS09925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WYH_RS09930	COG2326	polyphosphate kinase activity
WYH_RS09950	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WYH_RS09950	COG1372	Participates in initiation and elongation during chromosome replication
WYH_RS09975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WYH_RS09975	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WYH_RS09995	COG1131	(ABC) transporter
WYH_RS10035	COG0583	DNA-binding transcription factor activity
WYH_RS10045	COG0519	Catalyzes the synthesis of GMP from XMP
WYH_RS10045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WYH_RS10075	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WYH_RS10085	COG1960	acyl-CoA dehydrogenase activity
WYH_RS10095	COG1125	glycine betaine transport
WYH_RS10110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WYH_RS10115	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
WYH_RS10130	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WYH_RS10140	COG1674	ftsk spoiiie
WYH_RS10150	COG4771	TonB-dependent receptor
WYH_RS10165	COG0488	(ABC) transporter
WYH_RS10175	COG0686	Belongs to the AlaDH PNT family
WYH_RS10180	COG3706	GGDEF domain
WYH_RS10215	COG2205	protein histidine kinase activity
WYH_RS10225	COG0433	COG0433 Predicted ATPase
WYH_RS10230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WYH_RS10230	COG0512	Glutamine amidotransferase of anthranilate synthase
WYH_RS10235	COG0436	Aminotransferase
WYH_RS10240	COG0564	pseudouridine synthase activity
WYH_RS10250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WYH_RS10290	COG0514	ATP-dependent DNA helicase (RecQ)
WYH_RS10305	COG3186	Phenylalanine-4-hydroxylase
WYH_RS10315	COG3590	peptidase
WYH_RS10320	COG1132	(ABC) transporter
WYH_RS10330	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
WYH_RS10350	COG0070	glutamate synthase
WYH_RS10350	COG0067	glutamate synthase
WYH_RS10350	COG0069	glutamate synthase activity
WYH_RS10370	COG2175	clavaminate synthase activity
WYH_RS10375	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WYH_RS10395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WYH_RS10400	COG1012	belongs to the aldehyde dehydrogenase family
WYH_RS10405	COG2957	Belongs to the agmatine deiminase family
WYH_RS10415	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WYH_RS10420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WYH_RS10425	COG2833	Protein of unknown function (DUF455)
WYH_RS10430	COG0739	heme binding
WYH_RS10455	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_RS10470	COG0495	leucyl-tRNA aminoacylation
WYH_RS10495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WYH_RS10500	COG2902	Dehydrogenase
WYH_RS10510	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
WYH_RS10515	COG4152	abc transporter atp-binding protein
WYH_RS10540	COG0493	'glutamate synthase
WYH_RS10540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WYH_RS10555	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
WYH_RS10565	COG2124	cytochrome p450
WYH_RS10590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WYH_RS10615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WYH_RS10620	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_RS10630	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WYH_RS10635	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WYH_RS10650	COG0776	regulation of translation
WYH_RS10655	COG2188	Transcriptional regulator
WYH_RS10660	COG3104	oligopeptide transport
WYH_RS10665	COG1228	amidohydrolase
WYH_RS10675	COG0545	Peptidyl-prolyl cis-trans isomerase
WYH_RS10680	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WYH_RS10690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WYH_RS10705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WYH_RS10725	COG1473	amidohydrolase
WYH_RS10735	COG3511	phospholipase C
WYH_RS10755	COG3507	Belongs to the glycosyl hydrolase 43 family
WYH_RS10780	COG2115	Belongs to the xylose isomerase family
WYH_RS10785	COG1070	Carbohydrate kinase
WYH_RS10805	COG2186	Transcriptional regulator
WYH_RS10830	COG2755	lipolytic protein G-D-S-L family
WYH_RS10830	COG0657	acetylesterase activity
WYH_RS10850	COG0477	Major facilitator Superfamily
WYH_RS10860	COG3661	Belongs to the glycosyl hydrolase 67 family
WYH_RS10890	COG3507	Belongs to the glycosyl hydrolase 43 family
WYH_RS10900	COG0129	dihydroxy-acid dehydratase activity
WYH_RS10910	COG4566	intracellular signal transduction
WYH_RS10980	COG0501	Belongs to the peptidase M48B family
WYH_RS10990	COG3275	phosphorelay sensor kinase activity
WYH_RS10995	COG3279	Response regulator of the LytR AlgR family
WYH_RS11015	COG0590	tRNA wobble adenosine to inosine editing
WYH_RS11020	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WYH_RS11040	COG1570	exodeoxyribonuclease VII activity
WYH_RS11045	COG0151	Belongs to the GarS family
WYH_RS11050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WYH_RS11070	COG0316	Belongs to the HesB IscA family
WYH_RS11080	COG2151	metal-sulfur cluster biosynthetic enzyme
WYH_RS11085	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WYH_RS11090	COG0719	Fe-S assembly protein
WYH_RS11095	COG0396	ATPase activity
WYH_RS11105	COG0719	Fe-S assembly protein
WYH_RS11110	COG1959	2 iron, 2 sulfur cluster binding
WYH_RS11115	COG0167	dihydroorotate dehydrogenase activity
WYH_RS11135	COG2022	thiamine diphosphate biosynthetic process
WYH_RS11145	COG1612	heme a metabolic process
WYH_RS11155	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WYH_RS11160	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WYH_RS11195	COG3275	phosphorelay sensor kinase activity
WYH_RS11200	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
WYH_RS11200	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
WYH_RS11230	COG0517	IMP dehydrogenase activity
WYH_RS11235	COG0316	Belongs to the HesB IscA family
WYH_RS11265	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WYH_RS11270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WYH_RS11275	COG0237	dephospho-CoA kinase activity
WYH_RS11280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WYH_RS11285	COG0424	maF-like protein
WYH_RS11290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WYH_RS11295	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WYH_RS11300	COG1981	membrane
WYH_RS11305	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WYH_RS11320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WYH_RS11325	COG0445	tRNA wobble uridine modification
WYH_RS11330	COG0357	Ribosomal RNA small subunit methyltransferase G
WYH_RS11350	COG1956	GAF domain-containing protein
WYH_RS11365	COG0009	L-threonylcarbamoyladenylate synthase
WYH_RS11380	COG1329	Transcriptional regulator
WYH_RS11385	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WYH_RS11395	COG0739	heme binding
WYH_RS11400	COG0113	porphobilinogen synthase activity
WYH_RS11410	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WYH_RS11415	COG1872	DUF167
WYH_RS11420	COG0659	secondary active sulfate transmembrane transporter activity
WYH_RS11425	COG1793	dna ligase
WYH_RS11450	COG1064	alcohol dehydrogenase
WYH_RS11480	COG0739	heme binding
WYH_RS11485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WYH_RS11490	COG0667	Aldo Keto reductase
WYH_RS11495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WYH_RS11500	COG0799	negative regulation of ribosome biogenesis
WYH_RS11505	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WYH_RS11515	COG0793	Belongs to the peptidase S41A family
WYH_RS11525	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
WYH_RS11535	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
WYH_RS11540	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WYH_RS11545	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WYH_RS11550	COG1295	ribonuclease BN
WYH_RS11555	COG0484	heat shock protein binding
WYH_RS11560	COG0259	pyridoxamine-phosphate oxidase activity
WYH_RS11565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
WYH_RS11585	COG0482	sulfurtransferase activity
WYH_RS11615	COG2733	membrane
WYH_RS11635	COG2086	electron transfer activity
WYH_RS11645	COG0045	succinate-CoA ligase (ADP-forming) activity
WYH_RS11650	COG1218	3'(2'),5'-bisphosphate nucleotidase
WYH_RS11655	COG2885	chlorophyll binding
WYH_RS11660	COG1253	flavin adenine dinucleotide binding
WYH_RS11670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WYH_RS11675	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WYH_RS11680	COG0196	riboflavin kinase activity
WYH_RS11690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WYH_RS11695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WYH_RS11700	COG0588	phosphoglycerate mutase activity
WYH_RS11750	COG0308	aminopeptidase N
WYH_RS11755	COG1496	oxidoreductase activity
WYH_RS11770	COG2857	Cytochrome c1
WYH_RS11770	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WYH_RS11775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WYH_RS11785	COG2885	chlorophyll binding
WYH_RS11800	COG1858	cytochrome C peroxidase
WYH_RS11805	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WYH_RS11810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WYH_RS11820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WYH_RS11830	COG1192	Involved in chromosome partitioning
WYH_RS11850	COG1201	RNA secondary structure unwinding
WYH_RS11885	COG1494	fructose-1,6-bisphosphatase
WYH_RS11910	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WYH_RS11915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WYH_RS11925	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WYH_RS11930	COG0072	phenylalanine-tRNA ligase activity
WYH_RS11935	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
WYH_RS11960	COG0347	Belongs to the P(II) protein family
WYH_RS11965	COG0004	ammonium transporteR
WYH_RS11970	COG2885	chlorophyll binding
WYH_RS11970	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
WYH_RS11975	COG3453	Protein conserved in bacteria
WYH_RS11975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WYH_RS11980	COG1253	flavin adenine dinucleotide binding
WYH_RS11985	COG1278	Cold shock
WYH_RS11990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WYH_RS11995	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WYH_RS12010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WYH_RS12015	COG2814	Major facilitator Superfamily
WYH_RS12080	COG0156	8-amino-7-oxononanoate synthase activity
WYH_RS12140	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WYH_RS12155	COG1250	3-hydroxyacyl-CoA dehydrogenase
WYH_RS12160	COG2096	Adenosyltransferase
WYH_RS12170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WYH_RS12180	COG0281	malic enzyme
WYH_RS12180	COG0280	phosphate acetyltransferase
WYH_RS12190	COG3550	peptidyl-serine autophosphorylation
WYH_RS12260	COG4227	nucleotidyltransferase activity
WYH_RS12275	COG1230	cation diffusion facilitator family transporter
WYH_RS12315	COG0028	Belongs to the TPP enzyme family
WYH_RS12320	COG1012	belongs to the aldehyde dehydrogenase family
WYH_RS12335	COG0672	)-iron permease
WYH_RS12345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WYH_RS12350	COG1131	(ABC) transporter
WYH_RS12355	COG0842	Transport permease protein
WYH_RS12360	COG0842	Transport permease protein
WYH_RS12380	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WYH_RS12385	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
WYH_RS12390	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
WYH_RS12405	COG2217	Heavy metal translocating P-type atpase
WYH_RS12415	COG0596	Alpha beta hydrolase
WYH_RS12415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WYH_RS12415	COG2226	methyltransferase
WYH_RS12420	COG1620	l-lactate permease
WYH_RS12425	COG0475	glutathione-regulated potassium exporter activity
WYH_RS12430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WYH_RS12430	COG0574	Belongs to the PEP-utilizing enzyme family
WYH_RS12435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WYH_RS12470	COG3459	Glycosyltransferase 36 associated
WYH_RS12500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WYH_RS12505	COG0670	Belongs to the BI1 family
WYH_RS12515	COG0033	Phosphoglucomutase
WYH_RS12520	COG0129	dihydroxy-acid dehydratase activity
WYH_RS12525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WYH_RS12540	COG0126	phosphoglycerate kinase activity
WYH_RS12545	COG2801	Transposase and inactivated derivatives
WYH_RS12545	COG3415	Transposase
WYH_RS12580	COG3550	peptidyl-serine autophosphorylation
WYH_RS12630	COG2226	methyltransferase
WYH_RS12645	COG1937	Protein conserved in bacteria
WYH_RS12695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WYH_RS12705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WYH_RS12710	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WYH_RS12720	COG2132	Multicopper oxidase
WYH_RS12750	COG2801	Transposase and inactivated derivatives
WYH_RS12750	COG3415	Transposase
WYH_RS12760	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WYH_RS12775	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WYH_RS12780	COG1137	ATPase activity
WYH_RS12790	COG0668	transmembrane transport
WYH_RS12795	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WYH_RS12810	COG0124	histidyl-tRNA synthetase
WYH_RS12815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WYH_RS12820	COG2890	protein-(glutamine-N5) methyltransferase activity
WYH_RS12830	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WYH_RS12835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WYH_RS12840	COG2311	Membrane
WYH_RS12850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WYH_RS12865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WYH_RS12875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WYH_RS12875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WYH_RS12900	COG0459	protein refolding
WYH_RS12905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WYH_RS12910	COG0534	Mate efflux family protein
WYH_RS12920	COG0222	ribosome binding
WYH_RS12925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WYH_RS12930	COG3655	Transcriptional regulator
WYH_RS12940	COG0085	RNA polymerase activity
WYH_RS12945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WYH_RS12950	COG1902	pentaerythritol trinitrate reductase activity
WYH_RS12955	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WYH_RS12955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WYH_RS12965	COG0717	Belongs to the dCTP deaminase family
WYH_RS12980	COG0028	Belongs to the TPP enzyme family
WYH_RS12985	COG0643	Histidine kinase
WYH_RS12985	COG2198	Histidine kinase
WYH_RS12995	COG0745	RESPONSE REGULATOR receiver
WYH_RS13000	COG2201	protein-glutamate methylesterase activity
WYH_RS13010	COG5001	Diguanylate cyclase
WYH_RS13025	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
WYH_RS13035	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
WYH_RS13040	COG1012	belongs to the aldehyde dehydrogenase family
WYH_RS13060	COG4191	Histidine kinase
WYH_RS13065	COG4566	intracellular signal transduction
WYH_RS13080	COG3243	poly(R)-hydroxyalkanoic acid synthase
WYH_RS13095	COG0071	Belongs to the small heat shock protein (HSP20) family
WYH_RS13100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WYH_RS13125	COG0071	Belongs to the small heat shock protein (HSP20) family
WYH_RS13130	COG0071	Belongs to the small heat shock protein (HSP20) family
WYH_RS13145	COG0783	Belongs to the Dps family
WYH_RS13165	COG0071	Belongs to the small heat shock protein (HSP20) family
WYH_RS13170	COG0071	Belongs to the small heat shock protein (HSP20) family
WYH_RS13175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WYH_RS13180	COG0655	NAD(P)H dehydrogenase (quinone) activity
WYH_RS13195	COG0475	glutathione-regulated potassium exporter activity
WYH_RS13195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WYH_RS13205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WYH_RS13225	COG0583	DNA-binding transcription factor activity
WYH_RS13235	COG2948	multi-organism process
WYH_RS13245	COG3701	Conjugal transfer protein
WYH_RS13265	COG3451	type IV secretory pathway VirB4
WYH_RS13280	COG4962	Type ii secretion system protein e
WYH_RS13335	COG3621	Patatin-like phospholipase
WYH_RS13345	COG0741	lytic transglycosylase activity
WYH_RS13380	COG5489	Protein of unknown function (DUF736)
WYH_RS13400	COG4227	nucleotidyltransferase activity
WYH_RS13410	COG5425	PFAM Usg family protein
WYH_RS13415	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WYH_RS13420	COG0459	protein refolding
WYH_RS13425	COG0438	transferase activity, transferring glycosyl groups
WYH_RS13450	COG0501	Belongs to the peptidase M48B family
WYH_RS13460	COG3243	poly(R)-hydroxyalkanoic acid synthase
WYH_RS13480	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
WYH_RS13490	COG0668	transmembrane transport
WYH_RS13575	COG2884	Cell division ATP-binding protein ftsE
WYH_RS13585	COG1434	Gram-negative-bacterium-type cell wall biogenesis
WYH_RS13595	COG0287	Prephenate dehydrogenase
WYH_RS13600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WYH_RS13605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WYH_RS13610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WYH_RS13610	COG2813	Specifically methylates the guanine in position
WYH_RS13615	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WYH_RS13625	COG3383	formate dehydrogenase (NAD+) activity
WYH_RS13645	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
WYH_RS13660	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
WYH_RS13695	COG2032	superoxide dismutase activity
WYH_RS13705	COG2814	Major facilitator Superfamily
WYH_RS13710	COG0702	epimerase
WYH_RS13745	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WYH_RS13750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WYH_RS13760	COG0330	HflC and HflK could
WYH_RS13765	COG0330	HflC and HflK could
WYH_RS13770	COG0489	protein tyrosine kinase activity
WYH_RS13775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WYH_RS13775	COG2010	Cytochrome c
WYH_RS13780	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WYH_RS13795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WYH_RS13810	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WYH_RS13820	COG1959	2 iron, 2 sulfur cluster binding
WYH_RS13825	COG5583	Uncharacterized small protein (DUF2292)
WYH_RS13835	COG0730	response to heat
WYH_RS13840	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
WYH_RS13855	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WYH_RS13860	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WYH_RS13865	COG0509	glycine decarboxylation via glycine cleavage system
WYH_RS13870	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WYH_RS13875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WYH_RS13880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WYH_RS13925	COG4251	negative regulation of phosphorylation
WYH_RS13955	COG0318	PFAM AMP-dependent synthetase and ligase
WYH_RS13975	COG4765	Protein conserved in bacteria
WYH_RS13980	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WYH_RS13990	COG1115	amino acid carrier protein
WYH_RS14030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WYH_RS14035	COG0081	regulation of translation
WYH_RS14045	COG1546	Belongs to the CinA family
WYH_RS14045	COG1058	Belongs to the CinA family
WYH_RS14050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WYH_RS14060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
WYH_RS14070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WYH_RS14095	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
WYH_RS14105	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_RS14235	COG1012	belongs to the aldehyde dehydrogenase family
WYH_RS14245	COG0657	acetylesterase activity
WYH_RS14270	COG0248	Ppx GppA phosphatase
WYH_RS14275	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WYH_RS14280	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
WYH_RS14300	COG3451	type IV secretory pathway VirB4
WYH_RS14315	COG1196	nuclear chromosome segregation
WYH_RS14315	COG0741	lytic transglycosylase activity
WYH_RS14315	COG0739	heme binding
WYH_RS14355	COG4774	siderophore transport
WYH_RS14390	COG2271	Major facilitator Superfamily
WYH_RS14395	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
WYH_RS14400	COG3459	Glycosyltransferase 36 associated
WYH_RS14410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WYH_RS14415	COG0574	Belongs to the PEP-utilizing enzyme family
WYH_RS14415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WYH_RS14440	COG1448	Aminotransferase
WYH_RS14460	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WYH_RS14460	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WYH_RS14475	COG2983	Belongs to the UPF0260 family
WYH_RS14480	COG1999	signal sequence binding
WYH_RS14505	COG0629	single-stranded DNA binding
WYH_RS14525	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WYH_RS14530	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WYH_RS14550	COG0659	secondary active sulfate transmembrane transporter activity
WYH_RS14565	COG5265	(ABC) transporter
WYH_RS14580	COG0463	Glycosyl transferase, family 2
WYH_RS14650	COG0114	fumarate hydratase activity
WYH_RS14670	COG1285	pathogenesis
WYH_RS14685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WYH_RS14690	COG3001	Fructosamine kinase
WYH_RS14695	COG0730	response to heat
WYH_RS14700	COG1218	3'(2'),5'-bisphosphate nucleotidase
WYH_RS14710	COG0175	sulfate reduction
WYH_RS14715	COG1024	Enoyl-CoA hydratase
WYH_RS14720	COG1960	acyl-CoA dehydrogenase activity
WYH_RS14745	COG2030	dehydratase
WYH_RS14755	COG2376	Dihydroxyacetone kinase
WYH_RS14765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WYH_RS14785	COG0582	viral genome integration into host DNA
WYH_RS14795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WYH_RS14800	COG1404	Belongs to the peptidase S8 family
WYH_RS14805	COG0464	growth
WYH_RS14840	COG0783	Belongs to the Dps family
WYH_RS14860	COG2814	Major facilitator Superfamily
WYH_RS14900	COG1506	peptidase
WYH_RS14900	COG4946	Tricorn protease homolog
WYH_RS14900	COG0823	Involved in the tonB-independent uptake of proteins
WYH_RS14930	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WYH_RS14945	COG1671	Belongs to the UPF0178 family
WYH_RS14950	COG2824	Alkylphosphonate utilization operon protein PhnA
WYH_RS14955	COG1278	Cold shock
WYH_RS14990	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
WYH_RS15000	COG1881	PFAM PEBP family protein
WYH_RS15010	COG3384	dioxygenase
WYH_RS15020	COG1476	TRANSCRIPTIONal
WYH_RS15065	COG2171	N-acyltransferase activity
WYH_RS15075	COG0194	GDP metabolic process
WYH_RS15090	COG0131	Imidazoleglycerol-phosphate dehydratase
WYH_RS15095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WYH_RS15100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WYH_RS15110	COG0107	imidazoleglycerol-phosphate synthase activity
WYH_RS15115	COG0140	phosphoribosyl-ATP diphosphatase activity
WYH_RS15125	COG0824	Thioesterase
WYH_RS15145	COG0823	Involved in the tonB-independent uptake of proteins
WYH_RS15150	COG2885	chlorophyll binding
WYH_RS15160	COG0484	heat shock protein binding
WYH_RS15170	COG0471	metal ion transport
WYH_RS15180	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WYH_RS15190	COG0408	coproporphyrinogen oxidase activity
WYH_RS15245	COG4771	TonB-dependent receptor
WYH_RS15275	COG1309	transcriptional regulator
WYH_RS15280	COG0252	asparaginase activity
WYH_RS15310	COG2205	protein histidine kinase activity
WYH_RS15395	COG1741	Belongs to the pirin family
WYH_RS15430	COG3706	GGDEF domain
WYH_RS15435	COG4566	intracellular signal transduction
WYH_RS15445	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
WYH_RS15455	COG1684	flagellar biosynthetic protein fliR
WYH_RS15460	COG1987	bacterial-type flagellum assembly
WYH_RS15520	COG1677	Flagellar hook-basal body complex protein FliE
WYH_RS15545	COG1360	Flagellar Motor Protein
WYH_RS15555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WYH_RS15560	COG1256	bacterial-type flagellum assembly
WYH_RS15560	COG4786	Flagellar basal body rod
WYH_RS15570	COG1706	bacterial-type flagellum-dependent cell motility
WYH_RS15575	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WYH_RS15590	COG4786	Flagellar basal body rod
WYH_RS15595	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
WYH_RS15610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WYH_RS15655	COG0842	Transport permease protein
WYH_RS15660	COG0842	Transport permease protein
WYH_RS15665	COG1131	(ABC) transporter
WYH_RS15675	COG1309	transcriptional regulator
WYH_RS15680	COG0577	efflux transmembrane transporter activity
WYH_RS15680	COG1136	(ABC) transporter
WYH_RS15685	COG0577	efflux transmembrane transporter activity
WYH_RS15685	COG1136	(ABC) transporter
WYH_RS15690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WYH_RS15720	COG1846	Transcriptional regulator
WYH_RS15750	COG4770	biotin carboxylase activity
WYH_RS15765	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WYH_RS15775	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WYH_RS15775	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WYH_RS15780	COG0346	lactoylglutathione lyase activity
WYH_RS15785	COG2827	Endonuclease containing a URI domain
WYH_RS15805	COG0439	Biotin carboxylase
WYH_RS15810	COG0511	ligase activity, forming carbon-carbon bonds
WYH_RS15820	COG3848	Pyruvate phosphate dikinase
WYH_RS15820	COG0574	Belongs to the PEP-utilizing enzyme family
WYH_RS15835	COG0745	RESPONSE REGULATOR receiver
WYH_RS15865	COG0625	glutathione transferase activity
WYH_RS15870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WYH_RS15875	COG1846	Transcriptional regulator
WYH_RS15880	COG1024	Enoyl-CoA hydratase
WYH_RS15895	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WYH_RS15900	COG1960	acyl-CoA dehydrogenase activity
WYH_RS15925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WYH_RS15930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WYH_RS15935	COG0181	hydroxymethylbilane synthase activity
WYH_RS15950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WYH_RS15970	COG0556	nucleotide-excision repair
WYH_RS15985	COG2226	methyltransferase
WYH_RS15985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WYH_RS15985	COG0596	Alpha beta hydrolase
WYH_RS15990	COG2308	Evidence 4 Homologs of previously reported genes of
WYH_RS16025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WYH_RS16030	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
WYH_RS16100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WYH_RS16215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases