locus-tag	class	description
AMC99_RS00005	COG0217	transcriptional regulatory protein
AMC99_RS00010	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AMC99_RS00015	COG1393	Belongs to the ArsC family
AMC99_RS00020	COG3201	nicotinamide mononucleotide transporter
AMC99_RS00030	COG0584	glycerophosphoryl diester phosphodiesterase
AMC99_RS00035	COG0590	tRNA wobble adenosine to inosine editing
AMC99_RS00040	COG2814	Major facilitator Superfamily
AMC99_RS00045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMC99_RS00050	COG0527	aspartate kinase activity
AMC99_RS00065	COG2070	2-Nitropropane dioxygenase
AMC99_RS00100	COG0330	HflC and HflK could
AMC99_RS00120	COG0582	viral genome integration into host DNA
AMC99_RS00135	COG0741	lytic transglycosylase activity
AMC99_RS00150	COG1475	DNA binding
AMC99_RS00160	COG1476	TRANSCRIPTIONal
AMC99_RS00175	COG0758	DNA mediated transformation
AMC99_RS00185	COG0758	DNA mediated transformation
AMC99_RS00210	COG4227	nucleotidyltransferase activity
AMC99_RS00230	COG0629	single-stranded DNA binding
AMC99_RS00275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AMC99_RS00290	COG3727	T/G mismatch-specific endonuclease activity
AMC99_RS00350	COG0681	Belongs to the peptidase S26 family
AMC99_RS00500	COG2217	Heavy metal translocating P-type atpase
AMC99_RS00560	COG0745	RESPONSE REGULATOR receiver
AMC99_RS00585	COG0129	dihydroxy-acid dehydratase activity
AMC99_RS00600	COG1959	2 iron, 2 sulfur cluster binding
AMC99_RS00620	COG0288	reversible hydration of carbon dioxide
AMC99_RS00645	COG2223	nitrite transmembrane transporter activity
AMC99_RS00650	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AMC99_RS00655	COG1140	nitrate reductase beta subunit
AMC99_RS00660	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AMC99_RS00665	COG2181	nitrate reductase activity
AMC99_RS00670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMC99_RS00675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AMC99_RS00690	COG0521	Mo-molybdopterin cofactor biosynthetic process
AMC99_RS00695	COG0303	'Molybdopterin
AMC99_RS00710	COG0259	pyridoxamine-phosphate oxidase activity
AMC99_RS00715	COG1960	acyl-CoA dehydrogenase activity
AMC99_RS00735	COG0798	PFAM Bile acid sodium symporter
AMC99_RS00750	COG0583	DNA-binding transcription factor activity
AMC99_RS00765	COG1960	acyl-CoA dehydrogenase activity
AMC99_RS00785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AMC99_RS00790	COG3383	formate dehydrogenase (NAD+) activity
AMC99_RS00835	COG1132	(ABC) transporter
AMC99_RS00850	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AMC99_RS00850	COG2755	lipolytic protein G-D-S-L family
AMC99_RS00885	COG0438	transferase activity, transferring glycosyl groups
AMC99_RS00890	COG0489	protein tyrosine kinase activity
AMC99_RS00890	COG3206	protein involved in exopolysaccharide biosynthesis
AMC99_RS00905	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AMC99_RS00910	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AMC99_RS00925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMC99_RS00930	COG3932	Exopolysaccharide synthesis, ExoD
AMC99_RS00940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMC99_RS00945	COG4591	ABC-type transport system involved in lipoprotein release permease component
AMC99_RS00945	COG1136	(ABC) transporter
AMC99_RS00955	COG1309	transcriptional regulator
AMC99_RS00980	COG0489	protein tyrosine kinase activity
AMC99_RS00985	COG1758	RNA polymerase activity
AMC99_RS00990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMC99_RS01000	COG5328	Belongs to the UPF0262 family
AMC99_RS01010	COG0295	cytidine deaminase activity
AMC99_RS01015	COG2323	membrane
AMC99_RS01020	COG2866	Carboxypeptidase
AMC99_RS01035	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AMC99_RS01075	COG0594	ribonuclease P activity
AMC99_RS01080	COG0706	membrane insertase activity
AMC99_RS01085	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AMC99_RS01095	COG0625	glutathione transferase activity
AMC99_RS01110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMC99_RS01115	COG1301	dicarboxylic acid transport
AMC99_RS01125	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AMC99_RS01135	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AMC99_RS01140	COG2267	carboxylic ester hydrolase activity
AMC99_RS01145	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMC99_RS01155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AMC99_RS01165	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AMC99_RS01170	COG0268	Binds directly to 16S ribosomal RNA
AMC99_RS01175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMC99_RS01180	COG2226	methyltransferase
AMC99_RS01185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMC99_RS01200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AMC99_RS01205	COG0756	dUTP diphosphatase activity
AMC99_RS01225	COG0180	Tryptophanyl-tRNA synthetase
AMC99_RS01230	COG0728	peptidoglycan biosynthetic process
AMC99_RS01235	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AMC99_RS01240	COG4395	Tim44
AMC99_RS01270	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AMC99_RS01280	COG0450	alkyl hydroperoxide reductase
AMC99_RS01285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMC99_RS01290	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AMC99_RS01295	COG0632	four-way junction helicase activity
AMC99_RS01305	COG2255	four-way junction helicase activity
AMC99_RS01335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AMC99_RS01345	COG2989	Protein conserved in bacteria
AMC99_RS01355	COG0123	including yeast histone deacetylase and acetoin utilization protein
AMC99_RS01365	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AMC99_RS01385	COG0668	transmembrane transport
AMC99_RS01395	COG2367	Beta-lactamase
AMC99_RS01400	COG0454	-acetyltransferase
AMC99_RS01420	COG0714	Associated with various cellular activities
AMC99_RS01435	COG0077	Prephenate dehydratase
AMC99_RS01445	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AMC99_RS01480	COG3813	Protein conserved in bacteria
AMC99_RS01485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMC99_RS01515	COG3920	Histidine kinase
AMC99_RS01520	COG0784	Response regulator, receiver
AMC99_RS01560	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AMC99_RS01570	COG3243	poly(R)-hydroxyalkanoic acid synthase
AMC99_RS01575	COG0436	Aminotransferase
AMC99_RS01595	COG0745	RESPONSE REGULATOR receiver
AMC99_RS01600	COG1024	Enoyl-CoA hydratase
AMC99_RS01635	COG0646	methionine synthase
AMC99_RS01635	COG1410	methionine synthase
AMC99_RS01645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AMC99_RS01650	COG0509	glycine decarboxylation via glycine cleavage system
AMC99_RS01655	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMC99_RS01660	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMC99_RS01670	COG1024	Enoyl-CoA hydratase
AMC99_RS01675	COG1024	Enoyl-CoA hydratase
AMC99_RS01680	COG0346	lactoylglutathione lyase activity
AMC99_RS01695	COG0251	oxidation-reduction process
AMC99_RS01705	COG1609	Transcriptional regulator
AMC99_RS01710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMC99_RS01760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMC99_RS01775	COG1960	acyl-CoA dehydrogenase activity
AMC99_RS01780	COG1960	acyl-CoA dehydrogenase activity
AMC99_RS01795	COG0783	Belongs to the Dps family
AMC99_RS01805	COG0494	nUDIX hydrolase
AMC99_RS01820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMC99_RS01830	COG4770	biotin carboxylase activity
AMC99_RS01890	COG2070	2-Nitropropane dioxygenase
AMC99_RS01910	COG1309	transcriptional regulator
AMC99_RS01915	COG2072	flavoprotein involved in K transport
AMC99_RS01925	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AMC99_RS01950	COG3040	lipid binding
AMC99_RS01955	COG1278	Cold shock
AMC99_RS01965	COG3384	dioxygenase
AMC99_RS01975	COG2824	Alkylphosphonate utilization operon protein PhnA
AMC99_RS02035	COG2171	N-acyltransferase activity
AMC99_RS02050	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AMC99_RS02055	COG1960	acyl-CoA dehydrogenase activity
AMC99_RS02060	COG2211	Major facilitator Superfamily
AMC99_RS02065	COG1960	acyl-CoA dehydrogenase activity
AMC99_RS02070	COG1960	acyl-CoA dehydrogenase activity
AMC99_RS02080	COG0194	GDP metabolic process
AMC99_RS02095	COG0131	Imidazoleglycerol-phosphate dehydratase
AMC99_RS02100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AMC99_RS02105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AMC99_RS02115	COG0107	imidazoleglycerol-phosphate synthase activity
AMC99_RS02120	COG0140	phosphoribosyl-ATP diphosphatase activity
AMC99_RS02130	COG0824	Thioesterase
AMC99_RS02150	COG0823	Involved in the tonB-independent uptake of proteins
AMC99_RS02155	COG2885	chlorophyll binding
AMC99_RS02185	COG0471	metal ion transport
AMC99_RS02190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AMC99_RS02200	COG0408	coproporphyrinogen oxidase activity
AMC99_RS02260	COG1028	Short-chain dehydrogenase reductase Sdr
AMC99_RS02265	COG1028	Short-chain dehydrogenase reductase Sdr
AMC99_RS02295	COG2272	Belongs to the type-B carboxylesterase lipase family
AMC99_RS02300	COG4771	TonB-dependent receptor
AMC99_RS02305	COG4771	TonB-dependent receptor
AMC99_RS02310	COG2272	Belongs to the type-B carboxylesterase lipase family
AMC99_RS02315	COG2814	Major facilitator Superfamily
AMC99_RS02320	COG1024	Enoyl-CoA hydratase
AMC99_RS02320	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMC99_RS02330	COG0183	Belongs to the thiolase family
AMC99_RS02335	COG0318	PFAM AMP-dependent synthetase and ligase
AMC99_RS02340	COG1309	transcriptional regulator
AMC99_RS02355	COG1960	acyl-CoA dehydrogenase activity
AMC99_RS02360	COG2211	Major facilitator Superfamily
AMC99_RS02365	COG1960	acyl-CoA dehydrogenase activity
AMC99_RS02385	COG1028	Short-chain dehydrogenase reductase Sdr
AMC99_RS02420	COG3507	Belongs to the glycosyl hydrolase 43 family
AMC99_RS02425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMC99_RS02440	COG2721	sulfolactate sulfo-lyase activity
AMC99_RS02445	COG1904	glucuronate isomerase
AMC99_RS02450	COG0246	Mannitol dehydrogenase
AMC99_RS02470	COG0516	GMP reductase activity
AMC99_RS02470	COG0517	IMP dehydrogenase activity
AMC99_RS02475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMC99_RS02485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMC99_RS02490	COG0784	Response regulator, receiver
AMC99_RS02490	COG2205	protein histidine kinase activity
AMC99_RS02500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMC99_RS02530	COG0424	maF-like protein
AMC99_RS02535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AMC99_RS02555	COG2081	HI0933 family
AMC99_RS02560	COG2197	response regulator
AMC99_RS02565	COG0322	excinuclease ABC activity
AMC99_RS02570	COG0513	Belongs to the DEAD box helicase family
AMC99_RS02595	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AMC99_RS02605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMC99_RS02610	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AMC99_RS02615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AMC99_RS02630	COG1741	Belongs to the pirin family
AMC99_RS02635	COG0271	Belongs to the BolA IbaG family
AMC99_RS02660	COG5507	3-demethylubiquinone-9 3-methyltransferase
AMC99_RS02670	COG1733	regulation of RNA biosynthetic process
AMC99_RS02710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AMC99_RS02720	COG0628	permease
AMC99_RS02725	COG0681	Belongs to the peptidase S26 family
AMC99_RS02730	COG0736	holo-[acyl-carrier-protein] synthase activity
AMC99_RS02735	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AMC99_RS02740	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AMC99_RS02745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AMC99_RS02750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMC99_RS02755	COG0596	Alpha beta hydrolase
AMC99_RS02760	COG0109	protoheme IX farnesyltransferase activity
AMC99_RS02770	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AMC99_RS02810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AMC99_RS02820	COG0314	molybdopterin synthase activity
AMC99_RS02825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMC99_RS02835	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AMC99_RS02840	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AMC99_RS02870	COG0418	dihydroorotase activity
AMC99_RS02890	COG1012	belongs to the aldehyde dehydrogenase family
AMC99_RS02895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AMC99_RS02915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMC99_RS02925	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AMC99_RS02945	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMC99_RS02960	COG0789	Transcriptional regulator
AMC99_RS02980	COG1522	sequence-specific DNA binding
AMC99_RS03020	COG1278	Cold shock
AMC99_RS03030	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AMC99_RS03065	COG1047	Peptidyl-prolyl cis-trans
AMC99_RS03075	COG0640	Transcriptional regulator
AMC99_RS03090	COG3706	GGDEF domain
AMC99_RS03120	COG1522	sequence-specific DNA binding
AMC99_RS03140	COG0439	Biotin carboxylase
AMC99_RS03145	COG0511	ligase activity, forming carbon-carbon bonds
AMC99_RS03150	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AMC99_RS03170	COG1862	Preprotein translocase
AMC99_RS03175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMC99_RS03180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMC99_RS03200	COG1573	uracil-dna glycosylase
AMC99_RS03205	COG0488	(ABC) transporter
AMC99_RS03235	COG1605	Chorismate mutase
AMC99_RS03235	COG0287	Prephenate dehydrogenase
AMC99_RS03240	COG0142	geranyltranstransferase activity
AMC99_RS03245	COG0667	Aldo Keto reductase
AMC99_RS03250	COG1643	Atp-dependent helicase
AMC99_RS03275	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AMC99_RS03290	COG0776	regulation of translation
AMC99_RS03300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMC99_RS03320	COG0688	phosphatidylethanolamine metabolic process
AMC99_RS03325	COG1183	phosphatidylcholine synthase activity
AMC99_RS03335	COG0052	Belongs to the universal ribosomal protein uS2 family
AMC99_RS03340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMC99_RS03345	COG0528	UMP kinase activity
AMC99_RS03350	COG0233	cytoplasmic translational termination
AMC99_RS03355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AMC99_RS03365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AMC99_RS03370	COG0750	zinc metalloprotease
AMC99_RS03385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMC99_RS03390	COG0254	rRNA binding
AMC99_RS03420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMC99_RS03425	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AMC99_RS03430	COG1138	Cytochrome C-type biogenesis protein
AMC99_RS03440	COG3088	subunit of a heme lyase
AMC99_RS03450	COG3158	transport of potassium into the cell
AMC99_RS03460	COG2917	probably involved in intracellular septation
AMC99_RS03465	COG0552	protein localization to endoplasmic reticulum
AMC99_RS03470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMC99_RS03475	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AMC99_RS03480	COG5001	Diguanylate cyclase
AMC99_RS03480	COG3300	MHYT domain
AMC99_RS03500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMC99_RS03515	COG0583	DNA-binding transcription factor activity
AMC99_RS03520	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AMC99_RS03525	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AMC99_RS03530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMC99_RS03535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMC99_RS03540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AMC99_RS03570	COG2989	Protein conserved in bacteria
AMC99_RS03575	COG1435	thymidine kinase activity
AMC99_RS03580	COG1994	Peptidase M50
AMC99_RS03590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AMC99_RS03595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AMC99_RS03600	COG1185	polyribonucleotide nucleotidyltransferase activity
AMC99_RS03625	COG0842	Transport permease protein
AMC99_RS03645	COG1024	Enoyl-CoA hydratase
AMC99_RS03655	COG2211	Major facilitator Superfamily
AMC99_RS03660	COG4771	TonB-dependent receptor
AMC99_RS03665	COG1028	Short-chain dehydrogenase reductase Sdr
AMC99_RS03690	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMC99_RS03710	COG3118	belongs to the thioredoxin family
AMC99_RS03720	COG0450	alkyl hydroperoxide reductase
AMC99_RS03750	COG0640	Transcriptional regulator
AMC99_RS03755	COG0509	glycine decarboxylation via glycine cleavage system
AMC99_RS03765	COG2048	Heterodisulfide reductase, subunit B
AMC99_RS03780	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMC99_RS03805	COG0095	Lipoate-protein ligase
AMC99_RS03820	COG0123	including yeast histone deacetylase and acetoin utilization protein
AMC99_RS03825	COG2210	Belongs to the sulfur carrier protein TusA family
AMC99_RS03830	COG0425	Belongs to the sulfur carrier protein TusA family
AMC99_RS03840	COG0243	molybdopterin cofactor binding
AMC99_RS03845	COG0437	4 iron, 4 sulfur cluster binding
AMC99_RS03850	COG3302	dmso reductase anchor subunit
AMC99_RS03855	COG0489	protein tyrosine kinase activity
AMC99_RS03865	COG0450	alkyl hydroperoxide reductase
AMC99_RS03870	COG1271	oxidase subunit
AMC99_RS03875	COG1294	oxidase, subunit
AMC99_RS03880	COG2030	dehydratase
AMC99_RS03890	COG0686	Belongs to the AlaDH PNT family
AMC99_RS03895	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AMC99_RS03905	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AMC99_RS03915	COG0625	glutathione transferase activity
AMC99_RS03945	COG2304	oxidoreductase activity
AMC99_RS03955	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMC99_RS03960	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AMC99_RS03965	COG0181	hydroxymethylbilane synthase activity
AMC99_RS03980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMC99_RS03985	COG4232	protein-disulfide reductase activity
AMC99_RS03995	COG0556	nucleotide-excision repair
AMC99_RS04005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMC99_RS04005	COG2226	methyltransferase
AMC99_RS04005	COG0596	Alpha beta hydrolase
AMC99_RS04010	COG2308	Evidence 4 Homologs of previously reported genes of
AMC99_RS04040	COG0640	Transcriptional regulator
AMC99_RS04070	COG1217	gtp-binding protein TYPA
AMC99_RS04075	COG4771	TonB-dependent receptor
AMC99_RS04080	COG3152	Membrane
AMC99_RS04090	COG4181	ATPase activity
AMC99_RS04100	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMC99_RS04135	COG1970	mechanosensitive ion channel activity
AMC99_RS04155	COG3724	N-succinylarginine dihydrolase activity
AMC99_RS04160	COG3138	arginine N-succinyltransferase
AMC99_RS04170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AMC99_RS04180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMC99_RS04185	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AMC99_RS04190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMC99_RS04195	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AMC99_RS04200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMC99_RS04215	COG0105	UTP biosynthetic process
AMC99_RS04220	COG2020	methyltransferase activity
AMC99_RS04230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AMC99_RS04235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AMC99_RS04250	COG1045	serine acetyltransferase
AMC99_RS04260	COG1218	3'(2'),5'-bisphosphate nucleotidase
AMC99_RS04275	COG0175	sulfate reduction
AMC99_RS04280	COG1877	trehalose-phosphatase activity
AMC99_RS04285	COG3387	PFAM Glycoside hydrolase 15-related
AMC99_RS04290	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AMC99_RS04295	COG0745	RESPONSE REGULATOR receiver
AMC99_RS04305	COG0492	ferredoxin-NADP+ reductase activity
AMC99_RS04325	COG1748	Saccharopine dehydrogenase
AMC99_RS04360	COG2175	clavaminate synthase activity
AMC99_RS04370	COG0156	8-amino-7-oxononanoate synthase activity
AMC99_RS04375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AMC99_RS04380	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AMC99_RS04385	COG0758	DNA mediated transformation
AMC99_RS04395	COG1754	DNA topoisomerase type I activity
AMC99_RS04395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMC99_RS04420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AMC99_RS04425	COG0571	ribonuclease III activity
AMC99_RS04430	COG0681	Belongs to the peptidase S26 family
AMC99_RS04435	COG0166	Belongs to the GPI family
AMC99_RS04445	COG0513	Belongs to the DEAD box helicase family
AMC99_RS04455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMC99_RS04460	COG1396	sequence-specific DNA binding
AMC99_RS04460	COG3800	Transcriptional regulator
AMC99_RS04465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMC99_RS04475	COG0346	lactoylglutathione lyase activity
AMC99_RS04480	COG1024	Enoyl-CoA hydratase
AMC99_RS04490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMC99_RS04490	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMC99_RS04495	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AMC99_RS04505	COG4770	biotin carboxylase activity
AMC99_RS04510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMC99_RS04520	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AMC99_RS04530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMC99_RS04540	COG4974	Belongs to the 'phage' integrase family
AMC99_RS04545	COG0825	malonyl-CoA metabolic process
AMC99_RS04565	COG0494	nUDIX hydrolase
AMC99_RS04585	COG0302	gtp cyclohydrolase
AMC99_RS04595	COG0678	peroxiredoxin activity
AMC99_RS04595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AMC99_RS04600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AMC99_RS04605	COG2205	protein histidine kinase activity
AMC99_RS04610	COG0802	atpase or kinase
AMC99_RS04615	COG3178	'Phosphotransferase
AMC99_RS04620	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMC99_RS04630	COG1074	ATP-dependent DNA helicase activity
AMC99_RS04640	COG0483	inositol monophosphate 1-phosphatase activity
AMC99_RS04645	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AMC99_RS04660	COG0653	protein targeting
AMC99_RS04675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMC99_RS04680	COG5001	Diguanylate cyclase
AMC99_RS04680	COG2203	Gaf domain
AMC99_RS04680	COG3706	GGDEF domain
AMC99_RS04680	COG4251	negative regulation of phosphorylation
AMC99_RS04685	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AMC99_RS04700	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AMC99_RS04705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AMC99_RS04715	COG1028	Short-chain dehydrogenase reductase Sdr
AMC99_RS04725	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AMC99_RS04755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AMC99_RS04775	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AMC99_RS04780	COG0126	phosphoglycerate kinase activity
AMC99_RS04805	COG0352	thiamine-phosphate diphosphorylase activity
AMC99_RS04810	COG1376	ErfK ybiS ycfS ynhG family protein
AMC99_RS04815	COG4942	peptidase
AMC99_RS04825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMC99_RS04835	COG0483	inositol monophosphate 1-phosphatase activity
AMC99_RS04845	COG1196	nuclear chromosome segregation
AMC99_RS04845	COG3264	Mechanosensitive ion channel
AMC99_RS04850	COG3273	potassium ion transport
AMC99_RS04850	COG0471	metal ion transport
AMC99_RS04860	COG3800	Transcriptional regulator
AMC99_RS04860	COG1396	sequence-specific DNA binding
AMC99_RS04870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AMC99_RS04880	COG2204	response regulator
AMC99_RS04890	COG0385	Bile acid
AMC99_RS04900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AMC99_RS04905	COG0733	neurotransmitter:sodium symporter activity
AMC99_RS04935	COG1573	uracil-dna glycosylase
AMC99_RS04950	COG2814	Major facilitator Superfamily
AMC99_RS04955	COG0745	RESPONSE REGULATOR receiver
AMC99_RS04960	COG0704	Plays a role in the regulation of phosphate uptake
AMC99_RS04965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMC99_RS04975	COG0573	inorganic phosphate transmembrane transporter activity
AMC99_RS04985	COG3746	phosphate-selective porin O and P
AMC99_RS05000	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AMC99_RS05000	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AMC99_RS05035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMC99_RS05045	COG0596	Alpha beta hydrolase
AMC99_RS05060	COG2353	YceI-like domain
AMC99_RS05065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AMC99_RS05075	COG0028	Belongs to the TPP enzyme family
AMC99_RS05080	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMC99_RS05085	COG0560	Phosphoserine phosphatase
AMC99_RS05100	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMC99_RS05115	COG1722	exodeoxyribonuclease VII activity
AMC99_RS05120	COG0142	geranyltranstransferase activity
AMC99_RS05125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AMC99_RS05135	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AMC99_RS05140	COG1131	(ABC) transporter
AMC99_RS05145	COG0842	Transport permease protein
AMC99_RS05155	COG0343	queuine tRNA-ribosyltransferase activity
AMC99_RS05175	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AMC99_RS05190	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMC99_RS05200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMC99_RS05205	COG0698	ribose 5-phosphate isomerase
AMC99_RS05210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMC99_RS05215	COG0358	DNA primase activity
AMC99_RS05230	COG0505	Belongs to the CarA family
AMC99_RS05245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMC99_RS05280	COG0148	phosphopyruvate hydratase activity
AMC99_RS05295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AMC99_RS05315	COG0772	Belongs to the SEDS family
AMC99_RS05340	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AMC99_RS05360	COG0012	GTP binding
AMC99_RS05365	COG4221	oxidoreductase activity
AMC99_RS05370	COG0193	aminoacyl-tRNA hydrolase activity
AMC99_RS05375	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AMC99_RS05400	COG0752	glycyl-tRNA synthetase alpha subunit
AMC99_RS05410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMC99_RS05410	COG0574	Belongs to the PEP-utilizing enzyme family
AMC99_RS05425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AMC99_RS05430	COG0789	Transcriptional regulator
AMC99_RS05435	COG1960	acyl-CoA dehydrogenase activity
AMC99_RS05465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AMC99_RS05475	COG3876	Protein conserved in bacteria
AMC99_RS05495	COG0840	transmembrane signaling receptor activity
AMC99_RS05500	COG0840	transmembrane signaling receptor activity
AMC99_RS05505	COG0840	transmembrane signaling receptor activity
AMC99_RS05510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMC99_RS05535	COG0187	DNA topoisomerase II activity
AMC99_RS05545	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AMC99_RS05550	COG0792	nuclease activity
AMC99_RS05555	COG0189	ligase activity
AMC99_RS05560	COG0586	Pfam SNARE associated Golgi protein
AMC99_RS05565	COG4974	Belongs to the 'phage' integrase family
AMC99_RS05570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMC99_RS05580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AMC99_RS05585	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AMC99_RS05590	COG1420	regulation of RNA biosynthetic process
AMC99_RS05595	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMC99_RS05620	COG0443	Heat shock 70 kDa protein
AMC99_RS05625	COG0484	heat shock protein binding
AMC99_RS05635	COG1752	Esterase of the alpha-beta hydrolase superfamily
AMC99_RS05660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMC99_RS05670	COG0442	prolyl-tRNA aminoacylation
AMC99_RS05675	COG0557	exoribonuclease II activity
AMC99_RS05685	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMC99_RS05705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMC99_RS05720	COG2951	lytic endotransglycosylase activity
AMC99_RS05725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AMC99_RS05730	COG1686	Belongs to the peptidase S11 family
AMC99_RS05735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AMC99_RS05750	COG0084	hydrolase, TatD family'
AMC99_RS05755	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AMC99_RS05755	COG0321	lipoyl(octanoyl) transferase activity
AMC99_RS05760	COG3956	TIGRFAM MazG family protein
AMC99_RS05765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AMC99_RS05770	COG1923	regulation of RNA biosynthetic process
AMC99_RS05775	COG2204	response regulator
AMC99_RS05785	COG2204	response regulator
AMC99_RS05790	COG3852	Histidine kinase
AMC99_RS05800	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMC99_RS05800	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AMC99_RS05805	COG1546	Belongs to the CinA family
AMC99_RS05815	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AMC99_RS05820	COG0288	reversible hydration of carbon dioxide
AMC99_RS05850	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AMC99_RS05880	COG0022	dehydrogenase e1 component
AMC99_RS05880	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMC99_RS05885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AMC99_RS05900	COG0668	transmembrane transport
AMC99_RS05905	COG2814	Major facilitator Superfamily
AMC99_RS05920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMC99_RS05925	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AMC99_RS05930	COG0071	Belongs to the small heat shock protein (HSP20) family
AMC99_RS05935	COG0504	CTP synthase activity
AMC99_RS05945	COG0149	triose-phosphate isomerase activity
AMC99_RS05955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AMC99_RS05975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AMC99_RS05980	COG0134	indole-3-glycerol-phosphate synthase activity
AMC99_RS05985	COG0315	cyclic pyranopterin monophosphate synthase activity
AMC99_RS05990	COG0303	'Molybdopterin
AMC99_RS05995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMC99_RS06000	COG2333	competence protein COMEC
AMC99_RS06000	COG0658	competence protein
AMC99_RS06005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMC99_RS06010	COG0372	Belongs to the citrate synthase family
AMC99_RS06020	COG2205	protein histidine kinase activity
AMC99_RS06055	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AMC99_RS06065	COG1007	ATP synthesis coupled electron transport
AMC99_RS06080	COG0713	ATP synthesis coupled electron transport
AMC99_RS06090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMC99_RS06095	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AMC99_RS06100	COG1034	ATP synthesis coupled electron transport
AMC99_RS06110	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AMC99_RS06120	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AMC99_RS06125	COG0649	NAD binding
AMC99_RS06130	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMC99_RS06135	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMC99_RS06140	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMC99_RS06145	COG1012	belongs to the aldehyde dehydrogenase family
AMC99_RS06150	COG0183	Belongs to the thiolase family
AMC99_RS06175	COG0004	ammonium transporteR
AMC99_RS06205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AMC99_RS06210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AMC99_RS06215	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMC99_RS06220	COG1530	ribonuclease E activity
AMC99_RS06225	COG2226	methyltransferase
AMC99_RS06245	COG1213	nucleotidyl transferase
AMC99_RS06250	COG2244	polysaccharide biosynthetic process
AMC99_RS06260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AMC99_RS06270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AMC99_RS06280	COG1024	Enoyl-CoA hydratase
AMC99_RS06280	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMC99_RS06285	COG0367	asparagine synthase
AMC99_RS06305	COG0726	polysaccharide deacetylase
AMC99_RS06310	COG3409	Peptidoglycan-binding domain 1 protein
AMC99_RS06310	COG3267	Type II secretory pathway component ExeA
AMC99_RS06365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMC99_RS06370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AMC99_RS06370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMC99_RS06380	COG0129	dihydroxy-acid dehydratase activity
AMC99_RS06390	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AMC99_RS06410	COG0521	Mo-molybdopterin cofactor biosynthetic process
AMC99_RS06445	COG2311	Membrane
AMC99_RS06450	COG0386	Belongs to the glutathione peroxidase family
AMC99_RS06460	COG1136	(ABC) transporter
AMC99_RS06470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AMC99_RS06475	COG4221	oxidoreductase activity
AMC99_RS06490	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMC99_RS06495	COG0415	Belongs to the DNA photolyase family
AMC99_RS06505	COG0671	phosphoesterase, PA-phosphatase related
AMC99_RS06510	COG1013	pyruvate-flavodoxin oxidoreductase activity
AMC99_RS06515	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AMC99_RS06515	COG0674	pyruvate-flavodoxin oxidoreductase activity
AMC99_RS06520	COG0657	acetylesterase activity
AMC99_RS06525	COG1051	belongs to the nudix hydrolase family
AMC99_RS06535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMC99_RS06535	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AMC99_RS06550	COG1028	Short-chain dehydrogenase reductase Sdr
AMC99_RS06555	COG2321	neutral zinc metallopeptidase
AMC99_RS06565	COG4452	Inner membrane protein CreD
AMC99_RS06575	COG3682	Transcriptional regulator
AMC99_RS06580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AMC99_RS06600	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AMC99_RS06615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMC99_RS06620	COG2264	protein methyltransferase activity
AMC99_RS06625	COG1024	Enoyl-CoA hydratase
AMC99_RS06635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMC99_RS06650	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMC99_RS06695	COG0481	GTPase activity
AMC99_RS06700	COG5001	Diguanylate cyclase
AMC99_RS06705	COG3300	MHYT domain
AMC99_RS06705	COG5001	Diguanylate cyclase
AMC99_RS06720	COG0493	'glutamate synthase
AMC99_RS06730	COG0596	Alpha beta hydrolase
AMC99_RS06740	COG1064	alcohol dehydrogenase
AMC99_RS06765	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AMC99_RS06770	COG1619	proteins homologs of microcin C7 resistance protein MccF
AMC99_RS06775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMC99_RS06785	COG2354	Protein conserved in bacteria
AMC99_RS06790	COG0360	Binds together with S18 to 16S ribosomal RNA
AMC99_RS06795	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AMC99_RS06800	COG0359	binds to the 23S rRNA
AMC99_RS06810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AMC99_RS06815	COG1028	Short-chain dehydrogenase reductase Sdr
AMC99_RS06820	COG3920	Histidine kinase
AMC99_RS06825	COG0189	ligase activity
AMC99_RS06830	COG0189	ligase activity
AMC99_RS06830	COG4067	protein conserved in archaea
AMC99_RS06865	COG1566	PFAM secretion protein HlyD family protein
AMC99_RS06870	COG2814	Major facilitator Superfamily
AMC99_RS06880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AMC99_RS06890	COG0335	large ribosomal subunit rRNA binding
AMC99_RS06895	COG0336	Belongs to the RNA methyltransferase TrmD family
AMC99_RS06900	COG0492	ferredoxin-NADP+ reductase activity
AMC99_RS06910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AMC99_RS06915	COG0228	four-way junction DNA binding
AMC99_RS06920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AMC99_RS06935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AMC99_RS06945	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AMC99_RS06950	COG3647	Membrane
AMC99_RS06955	COG0539	negative regulation of cytoplasmic translation
AMC99_RS06960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMC99_RS06965	COG3321	synthase
AMC99_RS06965	COG4221	oxidoreductase activity
AMC99_RS06965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMC99_RS06965	COG0604	alcohol dehydrogenase
AMC99_RS06970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AMC99_RS06975	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AMC99_RS06985	COG0356	it plays a direct role in the translocation of protons across the membrane
AMC99_RS07010	COG2003	Belongs to the UPF0758 family
AMC99_RS07015	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AMC99_RS07025	COG0284	orotidine-5'-phosphate decarboxylase activity
AMC99_RS07030	COG0135	phosphoribosylanthranilate isomerase activity
AMC99_RS07035	COG0133	tryptophan synthase activity
AMC99_RS07045	COG0159	tryptophan synthase activity
AMC99_RS07050	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AMC99_RS07055	COG0285	dihydrofolate synthase activity
AMC99_RS07060	COG2223	nitrite transmembrane transporter activity
AMC99_RS07065	COG4638	Rieske (2fe-2S)
AMC99_RS07070	COG1187	pseudouridine synthase activity
AMC99_RS07075	COG0742	ribosomal rna small subunit methyltransferase
AMC99_RS07085	COG0210	DNA helicase
AMC99_RS07100	COG0277	FAD linked oxidase domain protein
AMC99_RS07125	COG0538	isocitrate dehydrogenase activity
AMC99_RS07130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMC99_RS07130	COG3153	acetyltransferase
AMC99_RS07135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMC99_RS07145	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMC99_RS07150	COG4106	trans-aconitate 2-methyltransferase activity
AMC99_RS07155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AMC99_RS07170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AMC99_RS07175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMC99_RS07180	COG0741	lytic transglycosylase activity
AMC99_RS07200	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AMC99_RS07210	COG2258	MOSC domain
AMC99_RS07220	COG0384	phenazine biosynthesis protein PhzF
AMC99_RS07230	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
AMC99_RS07235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AMC99_RS07250	COG0137	argininosuccinate synthase activity
AMC99_RS07255	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AMC99_RS07285	COG0222	ribosome binding
AMC99_RS07290	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMC99_RS07310	COG0339	signal peptide processing
AMC99_RS07315	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AMC99_RS07340	COG5001	Diguanylate cyclase
AMC99_RS07340	COG3300	MHYT domain
AMC99_RS07345	COG0039	L-malate dehydrogenase activity
AMC99_RS07350	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AMC99_RS07360	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMC99_RS07365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMC99_RS07385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMC99_RS07390	COG0154	amidase activity
AMC99_RS07395	COG2860	membrane
AMC99_RS07410	COG0203	ribosomal protein L17
AMC99_RS07415	COG0202	RNA polymerase activity
AMC99_RS07420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AMC99_RS07425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AMC99_RS07435	COG0563	adenylate kinase activity
AMC99_RS07440	COG0201	protein transport
AMC99_RS07445	COG0200	Binds to the 23S rRNA
AMC99_RS07455	COG1841	ribosomal large subunit assembly
AMC99_RS07460	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AMC99_RS07465	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AMC99_RS07470	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AMC99_RS07475	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AMC99_RS07480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AMC99_RS07485	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AMC99_RS07490	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AMC99_RS07495	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AMC99_RS07500	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AMC99_RS07505	COG0255	Belongs to the universal ribosomal protein uL29 family
AMC99_RS07510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AMC99_RS07515	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AMC99_RS07520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AMC99_RS07525	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AMC99_RS07530	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AMC99_RS07535	COG0089	rRNA binding
AMC99_RS07540	COG0088	Forms part of the polypeptide exit tunnel
AMC99_RS07545	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AMC99_RS07550	COG0051	transcription antitermination factor activity, RNA binding
AMC99_RS07555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMC99_RS07560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMC99_RS07565	COG0049	tRNA binding
AMC99_RS07570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AMC99_RS07605	COG1538	Outer membrane efflux protein
AMC99_RS07630	COG4964	Belongs to the GSP D family
AMC99_RS07690	COG0583	DNA-binding transcription factor activity
AMC99_RS07695	COG2967	ApaG domain
AMC99_RS07735	COG0473	3-isopropylmalate dehydrogenase activity
AMC99_RS07740	COG1381	Involved in DNA repair and RecF pathway recombination
AMC99_RS07755	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AMC99_RS07765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMC99_RS07770	COG1054	Belongs to the UPF0176 family
AMC99_RS07790	COG0625	glutathione transferase activity
AMC99_RS07805	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AMC99_RS07810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMC99_RS07820	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AMC99_RS07825	COG0612	Peptidase, M16
AMC99_RS07830	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AMC99_RS07835	COG0778	Nitroreductase
AMC99_RS07865	COG0583	DNA-binding transcription factor activity
AMC99_RS07870	COG1253	flavin adenine dinucleotide binding
AMC99_RS07875	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AMC99_RS07895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMC99_RS07915	COG2239	Acts as a magnesium transporter
AMC99_RS07925	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMC99_RS07930	COG2816	NAD+ diphosphatase activity
AMC99_RS07965	COG1196	nuclear chromosome segregation
AMC99_RS07980	COG0776	regulation of translation
AMC99_RS07985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMC99_RS07990	COG0416	fatty acid biosynthetic process
AMC99_RS08000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMC99_RS08025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMC99_RS08035	COG0215	cysteine-tRNA ligase activity
AMC99_RS08060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AMC99_RS08075	COG1733	regulation of RNA biosynthetic process
AMC99_RS08085	COG3046	protein related to deoxyribodipyrimidine photolyase
AMC99_RS08115	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMC99_RS08120	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AMC99_RS08125	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AMC99_RS08130	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AMC99_RS08135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AMC99_RS08155	COG1505	serine-type exopeptidase activity
AMC99_RS08170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AMC99_RS08175	COG0546	phosphoglycolate phosphatase activity
AMC99_RS08180	COG1028	Short-chain dehydrogenase reductase Sdr
AMC99_RS08200	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AMC99_RS08215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AMC99_RS08230	COG0779	Required for maturation of 30S ribosomal subunits
AMC99_RS08250	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AMC99_RS08255	COG1842	Phage shock protein A
AMC99_RS08290	COG2166	iron-sulfur cluster assembly
AMC99_RS08305	COG0824	Thioesterase
AMC99_RS08315	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMC99_RS08325	COG0066	3-isopropylmalate dehydratase activity
AMC99_RS08345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AMC99_RS08365	COG0248	Ppx GppA phosphatase
AMC99_RS08370	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AMC99_RS08375	COG0667	Aldo Keto reductase
AMC99_RS08380	COG1028	Short-chain dehydrogenase reductase Sdr
AMC99_RS08385	COG1960	acyl-CoA dehydrogenase activity
AMC99_RS08395	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMC99_RS08405	COG0612	Peptidase, M16
AMC99_RS08415	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMC99_RS08420	COG0047	phosphoribosylformylglycinamidine synthase activity
AMC99_RS08430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMC99_RS08435	COG0697	spore germination
AMC99_RS08440	COG1215	transferase activity, transferring glycosyl groups
AMC99_RS08480	COG0318	PFAM AMP-dependent synthetase and ligase
AMC99_RS08490	COG0385	Bile acid
AMC99_RS08495	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AMC99_RS08500	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AMC99_RS08505	COG1794	racemase activity, acting on amino acids and derivatives
AMC99_RS08540	COG2204	response regulator
AMC99_RS08545	COG1028	Short-chain dehydrogenase reductase Sdr
AMC99_RS08555	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AMC99_RS08570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AMC99_RS08575	COG2133	pyrroloquinoline quinone binding
AMC99_RS08590	COG0494	nUDIX hydrolase
AMC99_RS08595	COG0617	tRNA 3'-terminal CCA addition
AMC99_RS08610	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AMC99_RS08615	COG0693	protein deglycase activity
AMC99_RS08625	COG1104	cysteine desulfurase activity
AMC99_RS08630	COG1104	cysteine desulfurase activity
AMC99_RS08635	COG2945	thiolester hydrolase activity
AMC99_RS08660	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AMC99_RS08665	COG0745	RESPONSE REGULATOR receiver
AMC99_RS08670	COG2205	protein histidine kinase activity
AMC99_RS08675	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AMC99_RS08680	COG1660	Displays ATPase and GTPase activities
AMC99_RS08685	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMC99_RS08685	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMC99_RS08695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMC99_RS08705	COG1322	Protein conserved in bacteria
AMC99_RS08715	COG0242	peptide deformylase activity
AMC99_RS08720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AMC99_RS08725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AMC99_RS08735	COG0101	tRNA pseudouridine synthase activity
AMC99_RS08745	COG0252	asparaginase activity
AMC99_RS08765	COG0165	Argininosuccinate lyase
AMC99_RS08775	COG0019	diaminopimelate decarboxylase activity
AMC99_RS08780	COG1648	precorrin-2 dehydrogenase activity
AMC99_RS08780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMC99_RS08795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AMC99_RS08835	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AMC99_RS08840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMC99_RS08850	COG0438	transferase activity, transferring glycosyl groups
AMC99_RS08865	COG1695	Transcriptional regulator
AMC99_RS08870	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AMC99_RS08970	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AMC99_RS08985	COG2897	thiosulfate sulfurtransferase activity
AMC99_RS08990	COG0626	cystathionine gamma-synthase activity
AMC99_RS09000	COG1648	precorrin-2 dehydrogenase activity
AMC99_RS09000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMC99_RS09020	COG0175	sulfate reduction
AMC99_RS09030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMC99_RS09035	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AMC99_RS09040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AMC99_RS09055	COG0670	Belongs to the BI1 family
AMC99_RS09060	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AMC99_RS09085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AMC99_RS09090	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMC99_RS09100	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AMC99_RS09105	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMC99_RS09110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AMC99_RS09120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMC99_RS09125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMC99_RS09130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AMC99_RS09135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AMC99_RS09150	COG0275	rRNA processing
AMC99_RS09155	COG2001	Belongs to the MraZ family
AMC99_RS09170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMC99_RS09195	COG2154	pterin-4-alpha-carbinolamine dehydratase
AMC99_RS09200	COG0531	amino acid
AMC99_RS09205	COG4133	protoheme IX ABC transporter activity
AMC99_RS09210	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMC99_RS09215	COG0024	Methionine aminopeptidase
AMC99_RS09225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMC99_RS09235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AMC99_RS09240	COG0347	Belongs to the P(II) protein family
AMC99_RS09245	COG0174	glutamine synthetase
AMC99_RS09290	COG0729	surface antigen
AMC99_RS09295	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AMC99_RS09300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMC99_RS09305	COG2084	Dehydrogenase
AMC99_RS09310	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AMC99_RS09320	COG0805	protein transport
AMC99_RS09325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMC99_RS09330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMC99_RS09335	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AMC99_RS09340	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AMC99_RS09345	COG1472	Belongs to the glycosyl hydrolase 3 family
AMC99_RS09355	COG0018	arginyl-trna synthetase
AMC99_RS09365	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMC99_RS09370	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AMC99_RS09375	COG0328	RNA-DNA hybrid ribonuclease activity
AMC99_RS09400	COG4964	Belongs to the GSP D family
AMC99_RS09430	COG1024	Enoyl-CoA hydratase
AMC99_RS09450	COG0183	Belongs to the thiolase family
AMC99_RS09460	COG0457	Tetratricopeptide repeat
AMC99_RS09470	COG1960	acyl-CoA dehydrogenase activity
AMC99_RS09545	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMC99_RS09560	COG0154	amidase activity
AMC99_RS09565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMC99_RS09575	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AMC99_RS09580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMC99_RS09595	COG0546	phosphoglycolate phosphatase activity
AMC99_RS09620	COG1127	ABC transporter
AMC99_RS09625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMC99_RS09630	COG0525	valine-tRNA ligase activity
AMC99_RS09650	COG0730	response to heat
AMC99_RS09660	COG1215	transferase activity, transferring glycosyl groups
AMC99_RS09665	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AMC99_RS09690	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AMC99_RS09720	COG0564	pseudouridine synthase activity
AMC99_RS09725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMC99_RS09765	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AMC99_RS09770	COG0740	serine-type endopeptidase activity
AMC99_RS09780	COG0154	amidase activity
AMC99_RS09785	COG0544	peptidyl-prolyl cis-trans isomerase activity
AMC99_RS09800	COG1160	GTP binding
AMC99_RS09810	COG2311	Membrane
AMC99_RS09835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMC99_RS09840	COG0540	Belongs to the ATCase OTCase family
AMC99_RS09845	COG0616	signal peptide processing
AMC99_RS09855	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AMC99_RS09865	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AMC99_RS09885	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AMC99_RS09890	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AMC99_RS09905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMC99_RS09910	COG0432	Pfam Uncharacterised protein family UPF0047
AMC99_RS09925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AMC99_RS09930	COG0129	dihydroxy-acid dehydratase activity
AMC99_RS09935	COG0837	glucose binding
AMC99_RS09940	COG0800	Aldolase
AMC99_RS09955	COG0037	tRNA processing
AMC99_RS09985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMC99_RS10005	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AMC99_RS10025	COG1902	pentaerythritol trinitrate reductase activity
AMC99_RS10035	COG0321	lipoyl(octanoyl) transferase activity
AMC99_RS10060	COG4774	siderophore transport
AMC99_RS10065	COG2080	2 iron, 2 sulfur cluster binding
AMC99_RS10070	COG0235	Class ii aldolase
AMC99_RS10075	COG0534	Mate efflux family protein
AMC99_RS10080	COG2198	Histidine kinase
AMC99_RS10080	COG0643	Histidine kinase
AMC99_RS10090	COG0745	RESPONSE REGULATOR receiver
AMC99_RS10100	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AMC99_RS10105	COG5001	Diguanylate cyclase
AMC99_RS10125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMC99_RS10140	COG2072	flavoprotein involved in K transport
AMC99_RS10145	COG0604	alcohol dehydrogenase
AMC99_RS10160	COG4774	siderophore transport
AMC99_RS10175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AMC99_RS10185	COG1028	Short-chain dehydrogenase reductase Sdr
AMC99_RS10205	COG0745	RESPONSE REGULATOR receiver
AMC99_RS10210	COG1063	alcohol dehydrogenase
AMC99_RS10215	COG1960	acyl-CoA dehydrogenase activity
AMC99_RS10220	COG1028	Short-chain dehydrogenase reductase Sdr
AMC99_RS10260	COG0745	RESPONSE REGULATOR receiver
AMC99_RS10265	COG5002	protein histidine kinase activity
AMC99_RS10295	COG5001	Diguanylate cyclase
AMC99_RS10365	COG5265	(ABC) transporter
AMC99_RS10370	COG0612	Peptidase, M16
AMC99_RS10375	COG0659	secondary active sulfate transmembrane transporter activity
AMC99_RS10385	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AMC99_RS10390	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AMC99_RS10410	COG0629	single-stranded DNA binding
AMC99_RS10435	COG1999	signal sequence binding
AMC99_RS10440	COG2983	Belongs to the UPF0260 family
AMC99_RS10460	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMC99_RS10460	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMC99_RS10475	COG2885	chlorophyll binding
AMC99_RS10485	COG1448	Aminotransferase
AMC99_RS10500	COG0582	viral genome integration into host DNA
AMC99_RS10505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMC99_RS10525	COG1538	Outer membrane efflux protein
AMC99_RS10545	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AMC99_RS10545	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AMC99_RS10550	COG1002	Type II restriction enzyme, methylase subunits
AMC99_RS10560	COG3550	peptidyl-serine autophosphorylation
AMC99_RS10565	COG1396	sequence-specific DNA binding
AMC99_RS10580	COG1937	Protein conserved in bacteria
AMC99_RS10585	COG2132	Multicopper oxidase
AMC99_RS10595	COG1482	cell wall glycoprotein biosynthetic process
AMC99_RS10615	COG0183	Belongs to the thiolase family
AMC99_RS10620	COG1024	Enoyl-CoA hydratase
AMC99_RS10630	COG1629	transport
AMC99_RS10630	COG4774	siderophore transport
AMC99_RS10635	COG2072	flavoprotein involved in K transport
AMC99_RS10640	COG1058	Belongs to the CinA family
AMC99_RS10640	COG1546	Belongs to the CinA family
AMC99_RS10655	COG0081	regulation of translation
AMC99_RS10660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMC99_RS10700	COG1696	Membrane protein involved in D-alanine export
AMC99_RS10715	COG1115	amino acid carrier protein
AMC99_RS10735	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AMC99_RS10740	COG4765	Protein conserved in bacteria
AMC99_RS10760	COG0318	PFAM AMP-dependent synthetase and ligase
AMC99_RS10790	COG4251	negative regulation of phosphorylation
AMC99_RS10805	COG0784	Response regulator, receiver
AMC99_RS10805	COG2205	protein histidine kinase activity
AMC99_RS10820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AMC99_RS10830	COG0531	amino acid
AMC99_RS10835	COG4638	Rieske (2fe-2S)
AMC99_RS10845	COG4566	intracellular signal transduction
AMC99_RS10865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AMC99_RS10875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMC99_RS10875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AMC99_RS10885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMC99_RS10910	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AMC99_RS10920	COG0489	protein tyrosine kinase activity
AMC99_RS10930	COG0330	HflC and HflK could
AMC99_RS10935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMC99_RS10940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMC99_RS10945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMC99_RS10970	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMC99_RS10970	COG2813	Specifically methylates the guanine in position
AMC99_RS10975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMC99_RS10980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMC99_RS10985	COG0287	Prephenate dehydrogenase
AMC99_RS11010	COG2884	Cell division ATP-binding protein ftsE
AMC99_RS11035	COG1522	sequence-specific DNA binding
AMC99_RS11045	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AMC99_RS11065	COG0717	Belongs to the dCTP deaminase family
AMC99_RS11075	COG3268	Saccharopine dehydrogenase
AMC99_RS11080	COG4206	TonB-dependent receptor
AMC99_RS11100	COG2095	MarC family integral membrane protein
AMC99_RS11110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMC99_RS11115	COG0762	integral membrane protein
AMC99_RS11120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AMC99_RS11150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMC99_RS11150	COG1372	Participates in initiation and elongation during chromosome replication
AMC99_RS11170	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMC99_RS11170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMC99_RS11195	COG1131	(ABC) transporter
AMC99_RS11225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AMC99_RS11240	COG0519	Catalyzes the synthesis of GMP from XMP
AMC99_RS11240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMC99_RS11255	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMC99_RS11295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMC99_RS11305	COG1960	acyl-CoA dehydrogenase activity
AMC99_RS11310	COG3920	Histidine kinase
AMC99_RS11320	COG1125	glycine betaine transport
AMC99_RS11320	COG0517	IMP dehydrogenase activity
AMC99_RS11335	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AMC99_RS11340	COG0318	PFAM AMP-dependent synthetase and ligase
AMC99_RS11345	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AMC99_RS11350	COG3284	Transcriptional regulator
AMC99_RS11350	COG3284	Transcriptional regulator
AMC99_RS11355	COG1012	belongs to the aldehyde dehydrogenase family
AMC99_RS11370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AMC99_RS11375	COG0352	thiamine-phosphate diphosphorylase activity
AMC99_RS11380	COG1674	ftsk spoiiie
AMC99_RS11385	COG3706	GGDEF domain
AMC99_RS11420	COG2205	protein histidine kinase activity
AMC99_RS11425	COG0433	COG0433 Predicted ATPase
AMC99_RS11435	COG0564	pseudouridine synthase activity
AMC99_RS11445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AMC99_RS11455	COG1785	Belongs to the alkaline phosphatase family
AMC99_RS11505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMC99_RS11510	COG0183	Belongs to the thiolase family
AMC99_RS11515	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
AMC99_RS11525	COG3186	Phenylalanine-4-hydroxylase
AMC99_RS11540	COG1968	undecaprenyl-diphosphatase activity
AMC99_RS11545	COG3590	peptidase
AMC99_RS11550	COG1132	(ABC) transporter
AMC99_RS11560	COG0531	amino acid
AMC99_RS11570	COG0183	Belongs to the thiolase family
AMC99_RS11600	COG0070	glutamate synthase
AMC99_RS11600	COG0067	glutamate synthase
AMC99_RS11600	COG0069	glutamate synthase activity
AMC99_RS11620	COG1024	Enoyl-CoA hydratase
AMC99_RS11625	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AMC99_RS11660	COG0495	leucyl-tRNA aminoacylation
AMC99_RS11675	COG1028	Short-chain dehydrogenase reductase Sdr
AMC99_RS11690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AMC99_RS11710	COG0739	heme binding
AMC99_RS11715	COG2833	Protein of unknown function (DUF455)
AMC99_RS11720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AMC99_RS11725	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AMC99_RS11735	COG2957	Belongs to the agmatine deiminase family
AMC99_RS11745	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMC99_RS11760	COG1476	TRANSCRIPTIONal
AMC99_RS11765	COG0596	Alpha beta hydrolase
AMC99_RS11785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMC99_RS11805	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AMC99_RS11810	COG4152	abc transporter atp-binding protein
AMC99_RS11840	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
AMC99_RS11855	COG0776	regulation of translation
AMC99_RS11860	COG2188	Transcriptional regulator
AMC99_RS11870	COG0804	urea catabolic process
AMC99_RS11875	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AMC99_RS11895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AMC99_RS11905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMC99_RS11910	COG0138	bifunctional purine biosynthesis protein purh
AMC99_RS11940	COG1473	amidohydrolase
AMC99_RS12025	COG0657	acetylesterase activity
AMC99_RS12050	COG3275	phosphorelay sensor kinase activity
AMC99_RS12055	COG3279	Response regulator of the LytR AlgR family
AMC99_RS12075	COG0590	tRNA wobble adenosine to inosine editing
AMC99_RS12080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AMC99_RS12100	COG1570	exodeoxyribonuclease VII activity
AMC99_RS12105	COG0151	Belongs to the GarS family
AMC99_RS12115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMC99_RS12135	COG0316	Belongs to the HesB IscA family
AMC99_RS12150	COG2151	metal-sulfur cluster biosynthetic enzyme
AMC99_RS12160	COG0719	Fe-S assembly protein
AMC99_RS12165	COG0396	ATPase activity
AMC99_RS12180	COG0719	Fe-S assembly protein
AMC99_RS12185	COG1959	2 iron, 2 sulfur cluster binding
AMC99_RS12205	COG0167	dihydroorotate dehydrogenase activity
AMC99_RS12210	COG0405	Gamma-glutamyltransferase
AMC99_RS12215	COG1022	Amp-dependent synthetase and ligase
AMC99_RS12225	COG2022	thiamine diphosphate biosynthetic process
AMC99_RS12235	COG1612	heme a metabolic process
AMC99_RS12250	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AMC99_RS12255	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AMC99_RS12295	COG3275	phosphorelay sensor kinase activity
AMC99_RS12305	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AMC99_RS12335	COG0316	Belongs to the HesB IscA family
AMC99_RS12360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMC99_RS12365	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AMC99_RS12370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMC99_RS12375	COG0237	dephospho-CoA kinase activity
AMC99_RS12380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AMC99_RS12385	COG0424	maF-like protein
AMC99_RS12390	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AMC99_RS12395	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AMC99_RS12400	COG1981	membrane
AMC99_RS12405	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AMC99_RS12420	COG0069	glutamate synthase activity
AMC99_RS12435	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AMC99_RS12440	COG0445	tRNA wobble uridine modification
AMC99_RS12445	COG0357	Ribosomal RNA small subunit methyltransferase G
AMC99_RS12480	COG1956	GAF domain-containing protein
AMC99_RS12495	COG1960	acyl-CoA dehydrogenase activity
AMC99_RS12500	COG0009	L-threonylcarbamoyladenylate synthase
AMC99_RS12510	COG1329	Transcriptional regulator
AMC99_RS12515	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AMC99_RS12530	COG0741	lytic transglycosylase activity
AMC99_RS12530	COG0739	heme binding
AMC99_RS12530	COG1196	nuclear chromosome segregation
AMC99_RS12535	COG0113	porphobilinogen synthase activity
AMC99_RS12555	COG1872	DUF167
AMC99_RS12565	COG1793	dna ligase
AMC99_RS12605	COG0318	PFAM AMP-dependent synthetase and ligase
AMC99_RS12615	COG0739	heme binding
AMC99_RS12620	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AMC99_RS12625	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AMC99_RS12630	COG0799	negative regulation of ribosome biogenesis
AMC99_RS12635	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AMC99_RS12645	COG0793	Belongs to the peptidase S41A family
AMC99_RS12655	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AMC99_RS12665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMC99_RS12670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AMC99_RS12685	COG1091	dTDP-4-dehydrorhamnose reductase activity
AMC99_RS12690	COG1088	dTDP-glucose 4,6-dehydratase activity
AMC99_RS12695	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AMC99_RS12725	COG0297	glycogen (starch) synthase activity
AMC99_RS12750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AMC99_RS12780	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AMC99_RS12785	COG1295	ribonuclease BN
AMC99_RS12790	COG0484	heat shock protein binding
AMC99_RS12795	COG0259	pyridoxamine-phosphate oxidase activity
AMC99_RS12805	COG0384	phenazine biosynthesis protein PhzF
AMC99_RS12825	COG0482	sulfurtransferase activity
AMC99_RS12845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMC99_RS12855	COG2733	membrane
AMC99_RS12870	COG2086	electron transfer activity
AMC99_RS12880	COG0045	succinate-CoA ligase (ADP-forming) activity
AMC99_RS12885	COG1218	3'(2'),5'-bisphosphate nucleotidase
AMC99_RS12895	COG1253	flavin adenine dinucleotide binding
AMC99_RS12905	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AMC99_RS12910	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AMC99_RS12915	COG0196	riboflavin kinase activity
AMC99_RS12930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AMC99_RS12940	COG0588	phosphoglycerate mutase activity
AMC99_RS12960	COG3428	Bacterial PH domain
AMC99_RS12985	COG0308	aminopeptidase N
AMC99_RS12990	COG1496	oxidoreductase activity
AMC99_RS13000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AMC99_RS13010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMC99_RS13035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AMC99_RS13060	COG1201	RNA secondary structure unwinding
AMC99_RS13115	COG1494	fructose-1,6-bisphosphatase
AMC99_RS13135	COG1028	Short-chain dehydrogenase reductase Sdr
AMC99_RS13140	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AMC99_RS13145	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AMC99_RS13165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMC99_RS13170	COG0072	phenylalanine-tRNA ligase activity
AMC99_RS13175	COG4771	TonB-dependent receptor
AMC99_RS13185	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AMC99_RS13190	COG2267	carboxylic ester hydrolase activity
AMC99_RS13205	COG0347	Belongs to the P(II) protein family
AMC99_RS13210	COG0004	ammonium transporteR
AMC99_RS13215	COG4771	TonB-dependent receptor
AMC99_RS13245	COG1473	amidohydrolase
AMC99_RS13255	COG1278	Cold shock
AMC99_RS13260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMC99_RS13265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AMC99_RS13280	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AMC99_RS13290	COG2032	superoxide dismutase activity
AMC99_RS13295	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AMC99_RS13295	COG2885	chlorophyll binding
AMC99_RS13330	COG1238	metal cluster binding
AMC99_RS13335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMC99_RS13345	COG1764	response to oxidative stress
AMC99_RS13350	COG0156	8-amino-7-oxononanoate synthase activity
AMC99_RS13355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMC99_RS13405	COG0747	negative chemotaxis
AMC99_RS13415	COG3483	tryptophan 2,3-dioxygenase activity
AMC99_RS13420	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AMC99_RS13435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMC99_RS13450	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMC99_RS13470	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AMC99_RS13475	COG0280	phosphate acetyltransferase
AMC99_RS13475	COG0281	malic enzyme
AMC99_RS13495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AMC99_RS13510	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AMC99_RS13515	COG1137	ATPase activity
AMC99_RS13525	COG0668	transmembrane transport
AMC99_RS13530	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AMC99_RS13540	COG0124	histidyl-tRNA synthetase
AMC99_RS13545	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AMC99_RS13550	COG2890	protein-(glutamine-N5) methyltransferase activity
AMC99_RS13560	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AMC99_RS13565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMC99_RS13570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMC99_RS13595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMC99_RS13605	COG3920	Histidine kinase
AMC99_RS13610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMC99_RS13610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMC99_RS13635	COG0459	protein refolding
AMC99_RS13640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AMC99_RS13645	COG0534	Mate efflux family protein
AMC99_RS13655	COG0222	ribosome binding
AMC99_RS13660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AMC99_RS13680	COG3655	Transcriptional regulator
AMC99_RS13690	COG0085	RNA polymerase activity
AMC99_RS13695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AMC99_RS13715	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AMC99_RS13715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMC99_RS13730	COG0469	pyruvate kinase activity
AMC99_RS13740	COG3750	Belongs to the UPF0335 family
AMC99_RS13745	COG0393	Putative heavy-metal-binding