locus-tag	class	description
A6F69_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6F69_RS00010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6F69_RS00025	COG4771	TonB-dependent receptor
A6F69_RS00030	COG1802	Transcriptional regulator
A6F69_RS00035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6F69_RS00045	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
A6F69_RS00050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6F69_RS00055	COG1335	isochorismatase
A6F69_RS00070	COG0842	Transport permease protein
A6F69_RS00100	COG1185	polyribonucleotide nucleotidyltransferase activity
A6F69_RS00105	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6F69_RS00110	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6F69_RS00115	COG1994	Peptidase M50
A6F69_RS00120	COG1435	thymidine kinase activity
A6F69_RS00125	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6F69_RS00135	COG1846	Transcriptional regulator
A6F69_RS00140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6F69_RS00150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6F69_RS00165	COG0779	Required for maturation of 30S ribosomal subunits
A6F69_RS00180	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6F69_RS00185	COG1842	Phage shock protein A
A6F69_RS00225	COG2166	iron-sulfur cluster assembly
A6F69_RS00250	COG0824	Thioesterase
A6F69_RS00255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6F69_RS00275	COG0066	3-isopropylmalate dehydratase activity
A6F69_RS00290	COG0271	Belongs to the BolA IbaG family
A6F69_RS00295	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6F69_RS00315	COG0248	Ppx GppA phosphatase
A6F69_RS00320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6F69_RS00325	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
A6F69_RS00345	COG3451	type IV secretory pathway VirB4
A6F69_RS00350	COG3702	type iv secretory pathway
A6F69_RS00360	COG0741	lytic transglycosylase activity
A6F69_RS00360	COG1196	nuclear chromosome segregation
A6F69_RS00360	COG0739	heme binding
A6F69_RS00365	COG0667	Aldo Keto reductase
A6F69_RS00370	COG1028	Short-chain dehydrogenase reductase Sdr
A6F69_RS00375	COG1960	acyl-CoA dehydrogenase activity
A6F69_RS00385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6F69_RS00390	COG4771	TonB-dependent receptor
A6F69_RS00395	COG3842	ATPase activity
A6F69_RS00405	COG1840	ABC-type Fe3 transport system, periplasmic component
A6F69_RS00410	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F69_RS00420	COG0656	L-ascorbic acid biosynthetic process
A6F69_RS00425	COG0673	inositol 2-dehydrogenase activity
A6F69_RS00435	COG1960	acyl-CoA dehydrogenase activity
A6F69_RS00440	COG1960	acyl-CoA dehydrogenase activity
A6F69_RS00445	COG2211	Major facilitator Superfamily
A6F69_RS00455	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A6F69_RS00470	COG2171	N-acyltransferase activity
A6F69_RS00540	COG1278	Cold shock
A6F69_RS00555	COG0251	oxidation-reduction process
A6F69_RS00560	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6F69_RS00575	COG2070	2-Nitropropane dioxygenase
A6F69_RS00580	COG0492	ferredoxin-NADP+ reductase activity
A6F69_RS00630	COG4770	biotin carboxylase activity
A6F69_RS00635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6F69_RS00640	COG2814	Major facilitator Superfamily
A6F69_RS00650	COG0494	nUDIX hydrolase
A6F69_RS00660	COG0783	Belongs to the Dps family
A6F69_RS00680	COG1064	alcohol dehydrogenase
A6F69_RS00710	COG1024	Enoyl-CoA hydratase
A6F69_RS00740	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6F69_RS00745	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6F69_RS00750	COG0509	glycine decarboxylation via glycine cleavage system
A6F69_RS00755	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6F69_RS00770	COG1410	methionine synthase
A6F69_RS00770	COG0646	methionine synthase
A6F69_RS00785	COG1073	alpha beta
A6F69_RS00785	COG2226	methyltransferase
A6F69_RS00790	COG0686	Belongs to the AlaDH PNT family
A6F69_RS00795	COG0793	Belongs to the peptidase S41A family
A6F69_RS00795	COG4946	Tricorn protease homolog
A6F69_RS00825	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A6F69_RS00830	COG2116	formate transmembrane transporter activity
A6F69_RS00850	COG1522	sequence-specific DNA binding
A6F69_RS00855	COG2855	membrane
A6F69_RS00870	COG0717	Belongs to the dCTP deaminase family
A6F69_RS00875	COG1960	acyl-CoA dehydrogenase activity
A6F69_RS00880	COG3268	Saccharopine dehydrogenase
A6F69_RS00885	COG4206	TonB-dependent receptor
A6F69_RS00895	COG3118	belongs to the thioredoxin family
A6F69_RS00905	COG2095	MarC family integral membrane protein
A6F69_RS00915	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6F69_RS00920	COG0762	integral membrane protein
A6F69_RS00925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6F69_RS00975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6F69_RS00975	COG1372	Participates in initiation and elongation during chromosome replication
A6F69_RS00985	COG2610	gluconate transmembrane transporter activity
A6F69_RS01010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6F69_RS01010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6F69_RS01020	COG0583	DNA-binding transcription factor activity
A6F69_RS01040	COG1131	(ABC) transporter
A6F69_RS01070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6F69_RS01070	COG0519	Catalyzes the synthesis of GMP from XMP
A6F69_RS01085	COG1760	l-serine dehydratase
A6F69_RS01120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6F69_RS01125	COG1960	acyl-CoA dehydrogenase activity
A6F69_RS01130	COG1125	glycine betaine transport
A6F69_RS01135	COG1174	glycine betaine transport
A6F69_RS01145	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6F69_RS01150	COG0318	PFAM AMP-dependent synthetase and ligase
A6F69_RS01155	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A6F69_RS01160	COG4771	TonB-dependent receptor
A6F69_RS01170	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6F69_RS01175	COG0352	thiamine-phosphate diphosphorylase activity
A6F69_RS01180	COG1674	ftsk spoiiie
A6F69_RS01200	COG0189	ligase activity
A6F69_RS01215	COG3746	phosphate-selective porin O and P
A6F69_RS01255	COG2205	protein histidine kinase activity
A6F69_RS01260	COG0433	COG0433 Predicted ATPase
A6F69_RS01270	COG0564	pseudouridine synthase activity
A6F69_RS01280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6F69_RS01320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6F69_RS01325	COG0183	Belongs to the thiolase family
A6F69_RS01330	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
A6F69_RS01335	COG2326	polyphosphate kinase activity
A6F69_RS01340	COG3186	Phenylalanine-4-hydroxylase
A6F69_RS01350	COG1968	undecaprenyl-diphosphatase activity
A6F69_RS01355	COG3590	peptidase
A6F69_RS01360	COG1132	(ABC) transporter
A6F69_RS01375	COG0183	Belongs to the thiolase family
A6F69_RS01390	COG0067	glutamate synthase
A6F69_RS01390	COG0070	glutamate synthase
A6F69_RS01390	COG0069	glutamate synthase activity
A6F69_RS01405	COG1024	Enoyl-CoA hydratase
A6F69_RS01415	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6F69_RS01445	COG0495	leucyl-tRNA aminoacylation
A6F69_RS01475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6F69_RS01495	COG0739	heme binding
A6F69_RS01500	COG2833	Protein of unknown function (DUF455)
A6F69_RS01505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6F69_RS01510	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A6F69_RS01525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6F69_RS01540	COG1476	TRANSCRIPTIONal
A6F69_RS01560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6F69_RS01565	COG2902	Dehydrogenase
A6F69_RS01575	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6F69_RS01580	COG4152	abc transporter atp-binding protein
A6F69_RS01595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F69_RS01615	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
A6F69_RS01630	COG0776	regulation of translation
A6F69_RS01635	COG2188	Transcriptional regulator
A6F69_RS01640	COG3104	oligopeptide transport
A6F69_RS01645	COG1228	amidohydrolase
A6F69_RS01650	COG1228	amidohydrolase
A6F69_RS01660	COG2853	Lipoprotein
A6F69_RS01665	COG1024	Enoyl-CoA hydratase
A6F69_RS01670	COG1073	alpha beta
A6F69_RS01675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6F69_RS01685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F69_RS01695	COG0138	bifunctional purine biosynthesis protein purh
A6F69_RS01725	COG1473	amidohydrolase
A6F69_RS01800	COG1002	Type II restriction enzyme, methylase subunits
A6F69_RS01860	COG3275	phosphorelay sensor kinase activity
A6F69_RS01865	COG3279	Response regulator of the LytR AlgR family
A6F69_RS01880	COG0590	tRNA wobble adenosine to inosine editing
A6F69_RS01885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6F69_RS01900	COG1570	exodeoxyribonuclease VII activity
A6F69_RS01905	COG0151	Belongs to the GarS family
A6F69_RS01920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F69_RS01945	COG0316	Belongs to the HesB IscA family
A6F69_RS01950	COG2151	metal-sulfur cluster biosynthetic enzyme
A6F69_RS01965	COG0719	Fe-S assembly protein
A6F69_RS01970	COG0396	ATPase activity
A6F69_RS01990	COG0719	Fe-S assembly protein
A6F69_RS01995	COG1959	2 iron, 2 sulfur cluster binding
A6F69_RS02005	COG0167	dihydroorotate dehydrogenase activity
A6F69_RS02010	COG0405	Gamma-glutamyltransferase
A6F69_RS02015	COG1022	Amp-dependent synthetase and ligase
A6F69_RS02030	COG2022	thiamine diphosphate biosynthetic process
A6F69_RS02040	COG1612	heme a metabolic process
A6F69_RS02050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6F69_RS02055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6F69_RS02080	COG3275	phosphorelay sensor kinase activity
A6F69_RS02090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6F69_RS02145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6F69_RS02150	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6F69_RS02160	COG0237	dephospho-CoA kinase activity
A6F69_RS02165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6F69_RS02170	COG0424	maF-like protein
A6F69_RS02175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A6F69_RS02180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6F69_RS02195	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6F69_RS02220	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6F69_RS02225	COG0445	tRNA wobble uridine modification
A6F69_RS02230	COG0357	Ribosomal RNA small subunit methyltransferase G
A6F69_RS02245	COG1956	GAF domain-containing protein
A6F69_RS02260	COG1960	acyl-CoA dehydrogenase activity
A6F69_RS02265	COG0009	L-threonylcarbamoyladenylate synthase
A6F69_RS02280	COG1329	Transcriptional regulator
A6F69_RS02285	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A6F69_RS02300	COG0739	heme binding
A6F69_RS02305	COG0113	porphobilinogen synthase activity
A6F69_RS02320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6F69_RS02325	COG4946	Tricorn protease homolog
A6F69_RS02325	COG1506	peptidase
A6F69_RS02325	COG0823	Involved in the tonB-independent uptake of proteins
A6F69_RS02360	COG0318	PFAM AMP-dependent synthetase and ligase
A6F69_RS02370	COG0739	heme binding
A6F69_RS02375	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6F69_RS02380	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6F69_RS02385	COG0799	negative regulation of ribosome biogenesis
A6F69_RS02390	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6F69_RS02400	COG0793	Belongs to the peptidase S41A family
A6F69_RS02410	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
A6F69_RS02425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6F69_RS02430	COG1482	cell wall glycoprotein biosynthetic process
A6F69_RS02440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6F69_RS02465	COG2226	methyltransferase
A6F69_RS02525	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6F69_RS02530	COG1295	ribonuclease BN
A6F69_RS02535	COG0484	heat shock protein binding
A6F69_RS02540	COG0259	pyridoxamine-phosphate oxidase activity
A6F69_RS02565	COG0482	sulfurtransferase activity
A6F69_RS02595	COG2733	membrane
A6F69_RS02610	COG2086	electron transfer activity
A6F69_RS02620	COG0045	succinate-CoA ligase (ADP-forming) activity
A6F69_RS02625	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6F69_RS02630	COG2885	chlorophyll binding
A6F69_RS02635	COG1253	flavin adenine dinucleotide binding
A6F69_RS02645	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6F69_RS02650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6F69_RS02655	COG0196	riboflavin kinase activity
A6F69_RS02665	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6F69_RS02675	COG0588	phosphoglycerate mutase activity
A6F69_RS02690	COG1960	acyl-CoA dehydrogenase activity
A6F69_RS02695	COG1028	Short-chain dehydrogenase reductase Sdr
A6F69_RS02700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6F69_RS02705	COG0022	dehydrogenase e1 component
A6F69_RS02755	COG0318	PFAM AMP-dependent synthetase and ligase
A6F69_RS02765	COG1028	Short-chain dehydrogenase reductase Sdr
A6F69_RS02770	COG1960	acyl-CoA dehydrogenase activity
A6F69_RS02785	COG0183	Belongs to the thiolase family
A6F69_RS02795	COG1960	acyl-CoA dehydrogenase activity
A6F69_RS02815	COG2130	NADP-dependent
A6F69_RS02825	COG2130	NADP-dependent
A6F69_RS02830	COG0746	molybdenum cofactor guanylyltransferase activity
A6F69_RS02850	COG1028	Short-chain dehydrogenase reductase Sdr
A6F69_RS02855	COG1053	succinate dehydrogenase
A6F69_RS02900	COG2130	NADP-dependent
A6F69_RS02920	COG4206	TonB-dependent receptor
A6F69_RS02935	COG2814	Major facilitator Superfamily
A6F69_RS02950	COG1960	acyl-CoA dehydrogenase activity
A6F69_RS02980	COG0308	aminopeptidase N
A6F69_RS02985	COG1496	oxidoreductase activity
A6F69_RS02995	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6F69_RS03000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6F69_RS03000	COG2857	Cytochrome c1
A6F69_RS03005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6F69_RS03010	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6F69_RS03020	COG0175	sulfate reduction
A6F69_RS03035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6F69_RS03055	COG1201	RNA secondary structure unwinding
A6F69_RS03060	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A6F69_RS03110	COG1494	fructose-1,6-bisphosphatase
A6F69_RS03115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6F69_RS03115	COG2124	cytochrome p450
A6F69_RS03145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6F69_RS03150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6F69_RS03160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6F69_RS03165	COG0072	phenylalanine-tRNA ligase activity
A6F69_RS03170	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A6F69_RS03175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F69_RS03190	COG0347	Belongs to the P(II) protein family
A6F69_RS03195	COG0004	ammonium transporteR
A6F69_RS03200	COG4771	TonB-dependent receptor
A6F69_RS03225	COG1473	amidohydrolase
A6F69_RS03235	COG1278	Cold shock
A6F69_RS03240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6F69_RS03245	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6F69_RS03250	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6F69_RS03260	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6F69_RS03270	COG2885	chlorophyll binding
A6F69_RS03270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6F69_RS03280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6F69_RS03290	COG0156	8-amino-7-oxononanoate synthase activity
A6F69_RS03295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6F69_RS03345	COG4166	transmembrane transport
A6F69_RS03355	COG3483	tryptophan 2,3-dioxygenase activity
A6F69_RS03360	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A6F69_RS03370	COG0488	(ABC) transporter
A6F69_RS03380	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6F69_RS03405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F69_RS03415	COG2096	Adenosyltransferase
A6F69_RS03420	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6F69_RS03435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6F69_RS03440	COG0280	phosphate acetyltransferase
A6F69_RS03440	COG0281	malic enzyme
A6F69_RS03455	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6F69_RS03460	COG0668	transmembrane transport
A6F69_RS03470	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A6F69_RS03475	COG1137	ATPase activity
A6F69_RS03485	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6F69_RS03490	COG0124	histidyl-tRNA synthetase
A6F69_RS03495	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6F69_RS03500	COG2890	protein-(glutamine-N5) methyltransferase activity
A6F69_RS03510	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6F69_RS03515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6F69_RS03520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6F69_RS03545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6F69_RS03555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6F69_RS03555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6F69_RS03565	COG2367	Beta-lactamase
A6F69_RS03585	COG0459	protein refolding
A6F69_RS03590	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6F69_RS03600	COG0531	amino acid
A6F69_RS03605	COG4638	Rieske (2fe-2S)
A6F69_RS03610	COG0222	ribosome binding
A6F69_RS03615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6F69_RS03630	COG3655	Transcriptional regulator
A6F69_RS03645	COG0085	RNA polymerase activity
A6F69_RS03650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6F69_RS03660	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A6F69_RS03660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F69_RS03680	COG2205	protein histidine kinase activity
A6F69_RS03680	COG0784	Response regulator, receiver
A6F69_RS03685	COG3850	Histidine kinase
A6F69_RS03685	COG4999	Histidine kinase
A6F69_RS03685	COG3437	response regulator, receiver
A6F69_RS03685	COG2205	protein histidine kinase activity
A6F69_RS03705	COG1215	transferase activity, transferring glycosyl groups
A6F69_RS03710	COG0463	Glycosyl transferase, family 2
A6F69_RS03710	COG1216	Glycosyl transferase, family 2
A6F69_RS03715	COG0438	transferase activity, transferring glycosyl groups
A6F69_RS03740	COG2204	response regulator
A6F69_RS03750	COG4566	intracellular signal transduction
A6F69_RS03785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6F69_RS03790	COG2030	dehydratase
A6F69_RS03820	COG1136	(ABC) transporter
A6F69_RS03820	COG0577	efflux transmembrane transporter activity
A6F69_RS03845	COG1758	RNA polymerase activity
A6F69_RS03860	COG5328	Belongs to the UPF0262 family
A6F69_RS03870	COG0295	cytidine deaminase activity
A6F69_RS03880	COG2866	Carboxypeptidase
A6F69_RS03895	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6F69_RS03920	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6F69_RS03925	COG0594	ribonuclease P activity
A6F69_RS03930	COG0706	membrane insertase activity
A6F69_RS03935	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6F69_RS03955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6F69_RS03960	COG1301	dicarboxylic acid transport
A6F69_RS03970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6F69_RS03975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6F69_RS03980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6F69_RS03985	COG0194	GDP metabolic process
A6F69_RS03995	COG0131	Imidazoleglycerol-phosphate dehydratase
A6F69_RS04000	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6F69_RS04005	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6F69_RS04010	COG0107	imidazoleglycerol-phosphate synthase activity
A6F69_RS04015	COG0140	phosphoribosyl-ATP diphosphatase activity
A6F69_RS04025	COG0824	Thioesterase
A6F69_RS04045	COG0823	Involved in the tonB-independent uptake of proteins
A6F69_RS04050	COG2885	chlorophyll binding
A6F69_RS04055	COG0484	heat shock protein binding
A6F69_RS04060	COG2311	Membrane
A6F69_RS04075	COG0471	metal ion transport
A6F69_RS04085	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6F69_RS04095	COG0408	coproporphyrinogen oxidase activity
A6F69_RS04185	COG0450	alkyl hydroperoxide reductase
A6F69_RS04200	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6F69_RS04210	COG0783	Belongs to the Dps family
A6F69_RS04220	COG0450	alkyl hydroperoxide reductase
A6F69_RS04225	COG1271	oxidase subunit
A6F69_RS04230	COG1294	oxidase, subunit
A6F69_RS04250	COG0673	inositol 2-dehydrogenase activity
A6F69_RS04260	COG3119	arylsulfatase activity
A6F69_RS04270	COG2115	Belongs to the xylose isomerase family
A6F69_RS04275	COG1070	Carbohydrate kinase
A6F69_RS04280	COG0477	Major facilitator Superfamily
A6F69_RS04285	COG1472	Belongs to the glycosyl hydrolase 3 family
A6F69_RS04300	COG1028	Short-chain dehydrogenase reductase Sdr
A6F69_RS04315	COG1349	DNA-binding transcription factor activity
A6F69_RS04320	COG1304	FMN binding
A6F69_RS04330	COG3347	Dehydrogenase
A6F69_RS04330	COG1028	Short-chain dehydrogenase reductase Sdr
A6F69_RS04335	COG4952	isomerase
A6F69_RS04355	COG3940	Belongs to the glycosyl hydrolase 43 family
A6F69_RS04360	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
A6F69_RS04370	COG3254	rhamnose metabolic process
A6F69_RS04375	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A6F69_RS04380	COG3119	arylsulfatase activity
A6F69_RS04400	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A6F69_RS04400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6F69_RS04420	COG3119	arylsulfatase activity
A6F69_RS04435	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6F69_RS04455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F69_RS04470	COG2072	flavoprotein involved in K transport
A6F69_RS04480	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6F69_RS04490	COG2133	pyrroloquinoline quinone binding
A6F69_RS04495	COG0729	surface antigen
A6F69_RS04510	COG1305	Transglutaminase-like
A6F69_RS04520	COG2308	Evidence 4 Homologs of previously reported genes of
A6F69_RS04525	COG3268	Saccharopine dehydrogenase
A6F69_RS04530	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A6F69_RS04535	COG0471	metal ion transport
A6F69_RS04545	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A6F69_RS04555	COG4206	TonB-dependent receptor
A6F69_RS04565	COG3047	cAMP biosynthetic process
A6F69_RS04595	COG2010	Cytochrome c
A6F69_RS04625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6F69_RS04630	COG4771	TonB-dependent receptor
A6F69_RS04640	COG0457	Tetratricopeptide repeat
A6F69_RS04650	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A6F69_RS04655	COG3387	PFAM Glycoside hydrolase 15-related
A6F69_RS04675	COG0142	geranyltranstransferase activity
A6F69_RS04710	COG1914	H( )-stimulated, divalent metal cation uptake system
A6F69_RS04720	COG1085	galactose-1-phosphate uridylyltransferase
A6F69_RS04735	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F69_RS04750	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
A6F69_RS04770	COG0500	methyltransferase
A6F69_RS04775	COG1063	alcohol dehydrogenase
A6F69_RS04780	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
A6F69_RS04785	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A6F69_RS04790	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A6F69_RS04815	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A6F69_RS04820	COG0644	oxidoreductase
A6F69_RS04825	COG2211	Major facilitator Superfamily
A6F69_RS04830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6F69_RS04850	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A6F69_RS04860	COG1429	ligase activity, forming nitrogen-metal bonds
A6F69_RS04865	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
A6F69_RS04900	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
A6F69_RS04910	COG0156	8-amino-7-oxononanoate synthase activity
A6F69_RS04970	COG1937	Protein conserved in bacteria
A6F69_RS04995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F69_RS05010	COG4974	Belongs to the 'phage' integrase family
A6F69_RS05030	COG1960	acyl-CoA dehydrogenase activity
A6F69_RS05040	COG0288	reversible hydration of carbon dioxide
A6F69_RS05060	COG2223	nitrite transmembrane transporter activity
A6F69_RS05065	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A6F69_RS05070	COG1140	nitrate reductase beta subunit
A6F69_RS05075	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A6F69_RS05080	COG2181	nitrate reductase activity
A6F69_RS05090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6F69_RS05100	COG0314	molybdopterin synthase activity
A6F69_RS05105	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6F69_RS05110	COG0303	'Molybdopterin
A6F69_RS05125	COG0259	pyridoxamine-phosphate oxidase activity
A6F69_RS05130	COG1960	acyl-CoA dehydrogenase activity
A6F69_RS05140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6F69_RS05150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6F69_RS05155	COG0629	single-stranded DNA binding
A6F69_RS05185	COG0582	viral genome integration into host DNA
A6F69_RS05200	COG1448	Aminotransferase
A6F69_RS05215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6F69_RS05215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6F69_RS05230	COG2983	Belongs to the UPF0260 family
A6F69_RS05235	COG1999	signal sequence binding
A6F69_RS05250	COG0629	single-stranded DNA binding
A6F69_RS05275	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6F69_RS05280	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6F69_RS05290	COG0659	secondary active sulfate transmembrane transporter activity
A6F69_RS05295	COG0612	Peptidase, M16
A6F69_RS05300	COG5265	(ABC) transporter
A6F69_RS05350	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6F69_RS05355	COG0081	regulation of translation
A6F69_RS05360	COG3667	copper resistance
A6F69_RS05365	COG2132	Multicopper oxidase
A6F69_RS05370	COG1937	Protein conserved in bacteria
A6F69_RS05380	COG1546	Belongs to the CinA family
A6F69_RS05380	COG1058	Belongs to the CinA family
A6F69_RS05385	COG2072	flavoprotein involved in K transport
A6F69_RS05395	COG4771	TonB-dependent receptor
A6F69_RS05400	COG1960	acyl-CoA dehydrogenase activity
A6F69_RS05405	COG1024	Enoyl-CoA hydratase
A6F69_RS05410	COG0183	Belongs to the thiolase family
A6F69_RS05450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6F69_RS05460	COG2205	protein histidine kinase activity
A6F69_RS05465	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F69_RS05495	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A6F69_RS05500	COG0662	Cupin 2, conserved barrel domain protein
A6F69_RS05510	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6F69_RS05525	COG1960	acyl-CoA dehydrogenase activity
A6F69_RS05535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6F69_RS05535	COG3743	rRNA binding
A6F69_RS05545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6F69_RS05550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6F69_RS05555	COG0181	hydroxymethylbilane synthase activity
A6F69_RS05570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6F69_RS05585	COG0556	nucleotide-excision repair
A6F69_RS05600	COG0405	Gamma-glutamyltransferase
A6F69_RS05605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F69_RS05610	COG1217	gtp-binding protein TYPA
A6F69_RS05615	COG4771	TonB-dependent receptor
A6F69_RS05620	COG1714	RDD family
A6F69_RS05630	COG4181	ATPase activity
A6F69_RS05640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6F69_RS05680	COG1970	mechanosensitive ion channel activity
A6F69_RS05715	COG3724	N-succinylarginine dihydrolase activity
A6F69_RS05730	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6F69_RS05740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6F69_RS05745	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6F69_RS05750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6F69_RS05760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6F69_RS05770	COG0105	UTP biosynthetic process
A6F69_RS05785	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6F69_RS05790	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6F69_RS05805	COG1045	serine acetyltransferase
A6F69_RS05825	COG1028	Short-chain dehydrogenase reductase Sdr
A6F69_RS05830	COG0546	phosphoglycolate phosphatase activity
A6F69_RS05835	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6F69_RS05855	COG1505	serine-type exopeptidase activity
A6F69_RS05860	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6F69_RS05865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6F69_RS05870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6F69_RS05875	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6F69_RS05880	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6F69_RS05915	COG3046	protein related to deoxyribodipyrimidine photolyase
A6F69_RS05925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6F69_RS05940	COG0215	cysteine-tRNA ligase activity
A6F69_RS05960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F69_RS05970	COG0416	fatty acid biosynthetic process
A6F69_RS05975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6F69_RS05980	COG0776	regulation of translation
A6F69_RS05990	COG1196	nuclear chromosome segregation
A6F69_RS06010	COG1194	a g-specific adenine glycosylase
A6F69_RS06035	COG0300	oxidoreductase activity
A6F69_RS06060	COG2239	Acts as a magnesium transporter
A6F69_RS06085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6F69_RS06095	COG1702	phosphate starvation-inducible protein PhoH
A6F69_RS06105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6F69_RS06110	COG1253	flavin adenine dinucleotide binding
A6F69_RS06115	COG0583	DNA-binding transcription factor activity
A6F69_RS06140	COG1214	PFAM Peptidase M22, glycoprotease
A6F69_RS06145	COG0778	Nitroreductase
A6F69_RS06150	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6F69_RS06160	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A6F69_RS06170	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A6F69_RS06175	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
A6F69_RS06185	COG1028	Short-chain dehydrogenase reductase Sdr
A6F69_RS06195	COG2211	Major facilitator Superfamily
A6F69_RS06200	COG0625	glutathione transferase activity
A6F69_RS06215	COG2259	Doxx family
A6F69_RS06220	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A6F69_RS06225	COG1741	Belongs to the pirin family
A6F69_RS06230	COG0583	DNA-binding transcription factor activity
A6F69_RS06240	COG1054	Belongs to the UPF0176 family
A6F69_RS06245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6F69_RS06255	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A6F69_RS06270	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A6F69_RS06280	COG1381	Involved in DNA repair and RecF pathway recombination
A6F69_RS06285	COG0473	3-isopropylmalate dehydrogenase activity
A6F69_RS06320	COG2967	ApaG domain
A6F69_RS06345	COG0457	Tetratricopeptide repeat
A6F69_RS06390	COG4964	Belongs to the GSP D family
A6F69_RS06420	COG1538	Outer membrane efflux protein
A6F69_RS06435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F69_RS06450	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6F69_RS06455	COG0049	tRNA binding
A6F69_RS06460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6F69_RS06465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6F69_RS06470	COG0051	transcription antitermination factor activity, RNA binding
A6F69_RS06475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6F69_RS06480	COG0088	Forms part of the polypeptide exit tunnel
A6F69_RS06485	COG0089	rRNA binding
A6F69_RS06490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6F69_RS06495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6F69_RS06500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6F69_RS06505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6F69_RS06510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6F69_RS06515	COG0255	Belongs to the universal ribosomal protein uL29 family
A6F69_RS06520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6F69_RS06525	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6F69_RS06530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6F69_RS06535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6F69_RS06540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6F69_RS06545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6F69_RS06550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6F69_RS06555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6F69_RS06560	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6F69_RS06565	COG1841	ribosomal large subunit assembly
A6F69_RS06570	COG0200	Binds to the 23S rRNA
A6F69_RS06575	COG0201	protein transport
A6F69_RS06580	COG0563	adenylate kinase activity
A6F69_RS06590	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6F69_RS06595	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6F69_RS06600	COG0202	RNA polymerase activity
A6F69_RS06605	COG0203	ribosomal protein L17
A6F69_RS06620	COG1505	serine-type exopeptidase activity
A6F69_RS06635	COG2860	membrane
A6F69_RS06645	COG0154	amidase activity
A6F69_RS06650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6F69_RS06655	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F69_RS06665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6F69_RS06675	COG0039	L-malate dehydrogenase activity
A6F69_RS06680	COG5001	Diguanylate cyclase
A6F69_RS06700	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6F69_RS06705	COG0339	signal peptide processing
A6F69_RS06710	COG0071	Belongs to the small heat shock protein (HSP20) family
A6F69_RS06715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6F69_RS06740	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6F69_RS06745	COG0137	argininosuccinate synthase activity
A6F69_RS06755	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6F69_RS06770	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6F69_RS06785	COG0384	phenazine biosynthesis protein PhzF
A6F69_RS06795	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6F69_RS06810	COG0741	lytic transglycosylase activity
A6F69_RS06815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6F69_RS06825	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6F69_RS06850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6F69_RS06855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6F69_RS06865	COG3153	acetyltransferase
A6F69_RS06865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F69_RS06870	COG0538	isocitrate dehydrogenase activity
A6F69_RS06885	COG1121	(ABC) transporter
A6F69_RS06905	COG0513	Belongs to the DEAD box helicase family
A6F69_RS06915	COG0210	DNA helicase
A6F69_RS06920	COG0742	ribosomal rna small subunit methyltransferase
A6F69_RS06925	COG1187	pseudouridine synthase activity
A6F69_RS06930	COG4638	Rieske (2fe-2S)
A6F69_RS06935	COG2223	nitrite transmembrane transporter activity
A6F69_RS06940	COG0285	dihydrofolate synthase activity
A6F69_RS06945	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6F69_RS06950	COG0159	tryptophan synthase activity
A6F69_RS06955	COG0133	tryptophan synthase activity
A6F69_RS06965	COG0135	phosphoribosylanthranilate isomerase activity
A6F69_RS06970	COG0284	orotidine-5'-phosphate decarboxylase activity
A6F69_RS06980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6F69_RS06990	COG2003	Belongs to the UPF0758 family
A6F69_RS07015	COG0356	it plays a direct role in the translocation of protons across the membrane
A6F69_RS07030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6F69_RS07040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F69_RS07045	COG0539	negative regulation of cytoplasmic translation
A6F69_RS07050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6F69_RS07060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6F69_RS07075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6F69_RS07080	COG0228	four-way junction DNA binding
A6F69_RS07085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6F69_RS07095	COG0336	Belongs to the RNA methyltransferase TrmD family
A6F69_RS07100	COG0335	large ribosomal subunit rRNA binding
A6F69_RS07115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6F69_RS07155	COG4067	protein conserved in archaea
A6F69_RS07155	COG0189	ligase activity
A6F69_RS07160	COG0189	ligase activity
A6F69_RS07170	COG1028	Short-chain dehydrogenase reductase Sdr
A6F69_RS07175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6F69_RS07180	COG0359	binds to the 23S rRNA
A6F69_RS07185	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6F69_RS07190	COG0360	Binds together with S18 to 16S ribosomal RNA
A6F69_RS07195	COG2354	Protein conserved in bacteria
A6F69_RS07215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6F69_RS07220	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6F69_RS07225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6F69_RS07260	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A6F69_RS07265	COG0596	Alpha beta hydrolase
A6F69_RS07270	COG0493	'glutamate synthase
A6F69_RS07285	COG5001	Diguanylate cyclase
A6F69_RS07290	COG5001	Diguanylate cyclase
A6F69_RS07290	COG3300	MHYT domain
A6F69_RS07295	COG0481	GTPase activity
A6F69_RS07300	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6F69_RS07305	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6F69_RS07320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6F69_RS07330	COG4221	oxidoreductase activity
A6F69_RS07345	COG2264	protein methyltransferase activity
A6F69_RS07355	COG1028	Short-chain dehydrogenase reductase Sdr
A6F69_RS07365	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A6F69_RS07385	COG3682	Transcriptional regulator
A6F69_RS07400	COG1028	Short-chain dehydrogenase reductase Sdr
A6F69_RS07415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6F69_RS07415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6F69_RS07430	COG1051	belongs to the nudix hydrolase family
A6F69_RS07435	COG0657	acetylesterase activity
A6F69_RS07440	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A6F69_RS07440	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6F69_RS07445	COG1013	pyruvate-flavodoxin oxidoreductase activity
A6F69_RS07455	COG0415	Belongs to the DNA photolyase family
A6F69_RS07470	COG0300	oxidoreductase activity
A6F69_RS07475	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6F69_RS07485	COG1136	(ABC) transporter
A6F69_RS07495	COG0386	Belongs to the glutathione peroxidase family
A6F69_RS07505	COG0318	PFAM AMP-dependent synthetase and ligase
A6F69_RS07520	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6F69_RS07525	COG0741	lytic transglycosylase activity
A6F69_RS07550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6F69_RS07560	COG0129	dihydroxy-acid dehydratase activity
A6F69_RS07565	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6F69_RS07565	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6F69_RS07570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6F69_RS07575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6F69_RS07580	COG0318	PFAM AMP-dependent synthetase and ligase
A6F69_RS07595	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6F69_RS07595	COG1024	Enoyl-CoA hydratase
A6F69_RS07600	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6F69_RS07610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6F69_RS07625	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6F69_RS07635	COG2226	methyltransferase
A6F69_RS07640	COG1530	ribonuclease E activity
A6F69_RS07650	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6F69_RS07655	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6F69_RS07660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6F69_RS07675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6F69_RS07685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6F69_RS07710	COG0183	Belongs to the thiolase family
A6F69_RS07715	COG1012	belongs to the aldehyde dehydrogenase family
A6F69_RS07725	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6F69_RS07730	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6F69_RS07735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6F69_RS07740	COG0649	NAD binding
A6F69_RS07745	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A6F69_RS07755	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A6F69_RS07760	COG1034	ATP synthesis coupled electron transport
A6F69_RS07765	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6F69_RS07770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6F69_RS07780	COG0713	ATP synthesis coupled electron transport
A6F69_RS07795	COG1007	ATP synthesis coupled electron transport
A6F69_RS07805	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A6F69_RS07850	COG0372	Belongs to the citrate synthase family
A6F69_RS07855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F69_RS07865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6F69_RS07870	COG0303	'Molybdopterin
A6F69_RS07875	COG0315	cyclic pyranopterin monophosphate synthase activity
A6F69_RS07880	COG0134	indole-3-glycerol-phosphate synthase activity
A6F69_RS07885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6F69_RS07905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6F69_RS07910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6F69_RS07915	COG0149	triose-phosphate isomerase activity
A6F69_RS07925	COG0504	CTP synthase activity
A6F69_RS07930	COG0071	Belongs to the small heat shock protein (HSP20) family
A6F69_RS07940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F69_RS07960	COG0596	Alpha beta hydrolase
A6F69_RS07965	COG3264	Mechanosensitive ion channel
A6F69_RS07965	COG1511	domain protein
A6F69_RS07980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6F69_RS07985	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F69_RS07985	COG0022	dehydrogenase e1 component
A6F69_RS08015	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A6F69_RS08030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6F69_RS08045	COG0288	reversible hydration of carbon dioxide
A6F69_RS08060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6F69_RS08065	COG2867	negative regulation of translational initiation
A6F69_RS08070	COG1058	Belongs to the CinA family
A6F69_RS08070	COG1546	Belongs to the CinA family
A6F69_RS08075	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6F69_RS08075	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6F69_RS08095	COG5000	phosphorelay sensor kinase activity
A6F69_RS08100	COG2204	response regulator
A6F69_RS08105	COG1923	regulation of RNA biosynthetic process
A6F69_RS08110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6F69_RS08115	COG3956	TIGRFAM MazG family protein
A6F69_RS08120	COG0321	lipoyl(octanoyl) transferase activity
A6F69_RS08120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6F69_RS08125	COG0084	hydrolase, TatD family'
A6F69_RS08135	COG0470	DNA polymerase III
A6F69_RS08140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6F69_RS08145	COG1686	Belongs to the peptidase S11 family
A6F69_RS08150	COG2951	lytic endotransglycosylase activity
A6F69_RS08165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6F69_RS08175	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F69_RS08185	COG0557	exoribonuclease II activity
A6F69_RS08190	COG0442	prolyl-tRNA aminoacylation
A6F69_RS08195	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
A6F69_RS08200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6F69_RS08225	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6F69_RS08235	COG0484	heat shock protein binding
A6F69_RS08240	COG0443	Heat shock 70 kDa protein
A6F69_RS08255	COG0456	acetyltransferase
A6F69_RS08270	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6F69_RS08275	COG1420	regulation of RNA biosynthetic process
A6F69_RS08280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6F69_RS08285	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6F69_RS08290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6F69_RS08295	COG4974	Belongs to the 'phage' integrase family
A6F69_RS08300	COG0189	ligase activity
A6F69_RS08305	COG0792	nuclease activity
A6F69_RS08310	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6F69_RS08320	COG0187	DNA topoisomerase II activity
A6F69_RS08335	COG0542	response to heat
A6F69_RS08340	COG0840	transmembrane signaling receptor activity
A6F69_RS08355	COG3876	Protein conserved in bacteria
A6F69_RS08365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6F69_RS08385	COG1960	acyl-CoA dehydrogenase activity
A6F69_RS08395	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6F69_RS08410	COG0574	Belongs to the PEP-utilizing enzyme family
A6F69_RS08410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6F69_RS08415	COG0751	glycine-tRNA ligase activity
A6F69_RS08420	COG0752	glycyl-tRNA synthetase alpha subunit
A6F69_RS08435	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6F69_RS08445	COG0193	aminoacyl-tRNA hydrolase activity
A6F69_RS08455	COG0300	oxidoreductase activity
A6F69_RS08465	COG0012	GTP binding
A6F69_RS08475	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6F69_RS08500	COG0772	Belongs to the SEDS family
A6F69_RS08515	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6F69_RS08520	COG0148	phosphopyruvate hydratase activity
A6F69_RS08555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6F69_RS08570	COG0505	Belongs to the CarA family
A6F69_RS08580	COG0358	DNA primase activity
A6F69_RS08585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6F69_RS08590	COG1192	Involved in chromosome partitioning
A6F69_RS08595	COG0698	ribose 5-phosphate isomerase
A6F69_RS08600	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6F69_RS08610	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6F69_RS08630	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A6F69_RS08635	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6F69_RS08645	COG0343	queuine tRNA-ribosyltransferase activity
A6F69_RS08655	COG0842	Transport permease protein
A6F69_RS08660	COG1131	(ABC) transporter
A6F69_RS08665	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6F69_RS08675	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6F69_RS08680	COG0142	geranyltranstransferase activity
A6F69_RS08685	COG1722	exodeoxyribonuclease VII activity
A6F69_RS08700	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6F69_RS08725	COG0560	Phosphoserine phosphatase
A6F69_RS08730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6F69_RS08735	COG0028	Belongs to the TPP enzyme family
A6F69_RS08745	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6F69_RS08750	COG1304	FMN binding
A6F69_RS08765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6F69_RS08770	COG0484	heat shock protein binding
A6F69_RS08775	COG3618	amidohydrolase
A6F69_RS08800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6F69_RS08810	COG5002	protein histidine kinase activity
A6F69_RS08815	COG0573	inorganic phosphate transmembrane transporter activity
A6F69_RS08825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6F69_RS08830	COG0704	Plays a role in the regulation of phosphate uptake
A6F69_RS08835	COG0745	RESPONSE REGULATOR receiver
A6F69_RS08840	COG0587	DNA-directed DNA polymerase activity
A6F69_RS08855	COG0733	neurotransmitter:sodium symporter activity
A6F69_RS08860	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6F69_RS08870	COG0385	Bile acid
A6F69_RS08875	COG2204	response regulator
A6F69_RS08895	COG3273	potassium ion transport
A6F69_RS08895	COG0471	metal ion transport
A6F69_RS08905	COG0483	inositol monophosphate 1-phosphatase activity
A6F69_RS08910	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6F69_RS08920	COG0352	thiamine-phosphate diphosphorylase activity
A6F69_RS08925	COG3588	fructose-bisphosphate aldolase
A6F69_RS08930	COG0126	phosphoglycerate kinase activity
A6F69_RS08935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6F69_RS08950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6F69_RS08960	COG2211	Major facilitator Superfamily
A6F69_RS08960	COG2211	Major facilitator Superfamily
A6F69_RS08990	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6F69_RS09005	COG1028	Short-chain dehydrogenase reductase Sdr
A6F69_RS09010	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6F69_RS09020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6F69_RS09025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6F69_RS09035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6F69_RS09040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6F69_RS09055	COG0456	acetyltransferase
A6F69_RS09060	COG0653	protein targeting
A6F69_RS09070	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A6F69_RS09075	COG0483	inositol monophosphate 1-phosphatase activity
A6F69_RS09085	COG1074	ATP-dependent DNA helicase activity
A6F69_RS09095	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6F69_RS09100	COG3178	'Phosphotransferase
A6F69_RS09105	COG0802	atpase or kinase
A6F69_RS09110	COG2205	protein histidine kinase activity
A6F69_RS09115	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A6F69_RS09120	COG0678	peroxiredoxin activity
A6F69_RS09120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6F69_RS09145	COG0302	gtp cyclohydrolase
A6F69_RS09155	COG0494	nUDIX hydrolase
A6F69_RS09175	COG0825	malonyl-CoA metabolic process
A6F69_RS09180	COG4974	Belongs to the 'phage' integrase family
A6F69_RS09190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6F69_RS09195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6F69_RS09200	COG3104	oligopeptide transport
A6F69_RS09205	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A6F69_RS09210	COG1024	Enoyl-CoA hydratase
A6F69_RS09220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F69_RS09225	COG4770	biotin carboxylase activity
A6F69_RS09235	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6F69_RS09235	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6F69_RS09240	COG1024	Enoyl-CoA hydratase
A6F69_RS09245	COG0346	lactoylglutathione lyase activity
A6F69_RS09260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6F69_RS09265	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A6F69_RS09270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6F69_RS09285	COG0513	Belongs to the DEAD box helicase family
A6F69_RS09295	COG1476	TRANSCRIPTIONal
A6F69_RS09300	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A6F69_RS09305	COG0166	Belongs to the GPI family
A6F69_RS09310	COG0681	Belongs to the peptidase S26 family
A6F69_RS09315	COG0571	ribonuclease III activity
A6F69_RS09320	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6F69_RS09325	COG3174	membrane
A6F69_RS09340	COG1754	DNA topoisomerase type I activity
A6F69_RS09340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6F69_RS09345	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6F69_RS09350	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6F69_RS09355	COG0156	8-amino-7-oxononanoate synthase activity
A6F69_RS09360	COG2175	clavaminate synthase activity
A6F69_RS09380	COG0463	Glycosyl transferase, family 2
A6F69_RS09400	COG1748	Saccharopine dehydrogenase
A6F69_RS09460	COG0494	nUDIX hydrolase
A6F69_RS09550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6F69_RS09555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6F69_RS09560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6F69_RS09570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6F69_RS09575	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6F69_RS09580	COG0583	DNA-binding transcription factor activity
A6F69_RS09590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6F69_RS09605	COG0028	Belongs to the TPP enzyme family
A6F69_RS09615	COG3300	MHYT domain
A6F69_RS09615	COG5001	Diguanylate cyclase
A6F69_RS09620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6F69_RS09625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6F69_RS09630	COG0552	protein localization to endoplasmic reticulum
A6F69_RS09635	COG2917	probably involved in intracellular septation
A6F69_RS09650	COG3158	transport of potassium into the cell
A6F69_RS09660	COG3088	subunit of a heme lyase
A6F69_RS09665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6F69_RS09670	COG1138	Cytochrome C-type biogenesis protein
A6F69_RS09675	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A6F69_RS09680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6F69_RS09685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6F69_RS09700	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6F69_RS09705	COG0254	rRNA binding
A6F69_RS09710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6F69_RS09720	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6F69_RS09725	COG0750	zinc metalloprotease
A6F69_RS09730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6F69_RS09740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6F69_RS09745	COG0233	cytoplasmic translational termination
A6F69_RS09750	COG0528	UMP kinase activity
A6F69_RS09755	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6F69_RS09760	COG0052	Belongs to the universal ribosomal protein uS2 family
A6F69_RS09770	COG0688	phosphatidylethanolamine metabolic process
A6F69_RS09790	COG2391	methyltransferase activity
A6F69_RS09805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6F69_RS09815	COG0776	regulation of translation
A6F69_RS09830	COG0235	Class ii aldolase
A6F69_RS09860	COG1643	Atp-dependent helicase
A6F69_RS09870	COG0142	geranyltranstransferase activity
A6F69_RS09875	COG1605	Chorismate mutase
A6F69_RS09875	COG0287	Prephenate dehydrogenase
A6F69_RS09895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6F69_RS09900	COG0488	(ABC) transporter
A6F69_RS09915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6F69_RS09920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6F69_RS09925	COG1862	Preprotein translocase
A6F69_RS09935	COG2301	Belongs to the HpcH HpaI aldolase family
A6F69_RS09950	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6F69_RS09955	COG0511	ligase activity, forming carbon-carbon bonds
A6F69_RS09960	COG0439	Biotin carboxylase
A6F69_RS09970	COG1522	sequence-specific DNA binding
A6F69_RS09975	COG2205	protein histidine kinase activity
A6F69_RS09975	COG2202	Pas domain
A6F69_RS09995	COG3706	GGDEF domain
A6F69_RS10010	COG1047	Peptidyl-prolyl cis-trans
A6F69_RS10040	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A6F69_RS10055	COG0789	Transcriptional regulator
A6F69_RS10070	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6F69_RS10075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6F69_RS10100	COG0438	transferase activity, transferring glycosyl groups
A6F69_RS10110	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6F69_RS10115	COG1012	belongs to the aldehyde dehydrogenase family
A6F69_RS10130	COG0418	dihydroorotase activity
A6F69_RS10170	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6F69_RS10175	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6F69_RS10185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6F69_RS10205	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6F69_RS10220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6F69_RS10245	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A6F69_RS10250	COG0109	protoheme IX farnesyltransferase activity
A6F69_RS10255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6F69_RS10260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6F69_RS10265	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6F69_RS10270	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6F69_RS10280	COG0736	holo-[acyl-carrier-protein] synthase activity
A6F69_RS10285	COG0681	Belongs to the peptidase S26 family
A6F69_RS10295	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6F69_RS10310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6F69_RS10345	COG1741	Belongs to the pirin family
A6F69_RS10350	COG1028	Short-chain dehydrogenase reductase Sdr
A6F69_RS10355	COG0596	Alpha beta hydrolase
A6F69_RS10365	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6F69_RS10370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6F69_RS10375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6F69_RS10380	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6F69_RS10385	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A6F69_RS10390	COG1946	Acyl-CoA thioesterase
A6F69_RS10415	COG0322	excinuclease ABC activity
A6F69_RS10420	COG0531	amino acid
A6F69_RS10425	COG2081	HI0933 family
A6F69_RS10445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6F69_RS10450	COG0424	maF-like protein
A6F69_RS10465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6F69_RS10470	COG0612	Peptidase, M16
A6F69_RS10475	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6F69_RS10480	COG0047	phosphoribosylformylglycinamidine synthase activity
A6F69_RS10485	COG5001	Diguanylate cyclase
A6F69_RS10490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6F69_RS10495	COG0697	spore germination
A6F69_RS10510	COG0697	spore germination
A6F69_RS10535	COG0385	Bile acid
A6F69_RS10545	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6F69_RS10585	COG3540	Alkaline phosphatase
A6F69_RS10590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6F69_RS10595	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A6F69_RS10605	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6F69_RS10610	COG2133	pyrroloquinoline quinone binding
A6F69_RS10630	COG0617	tRNA 3'-terminal CCA addition
A6F69_RS10640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6F69_RS10660	COG1104	cysteine desulfurase activity
A6F69_RS10665	COG1104	cysteine desulfurase activity
A6F69_RS10670	COG2945	thiolester hydrolase activity
A6F69_RS10695	COG1063	alcohol dehydrogenase
A6F69_RS10705	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6F69_RS10710	COG0745	RESPONSE REGULATOR receiver
A6F69_RS10715	COG2205	protein histidine kinase activity
A6F69_RS10725	COG1660	Displays ATPase and GTPase activities
A6F69_RS10730	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6F69_RS10730	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6F69_RS10740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6F69_RS10745	COG1322	Protein conserved in bacteria
A6F69_RS10750	COG0242	peptide deformylase activity
A6F69_RS10755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6F69_RS10760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6F69_RS10765	COG0101	tRNA pseudouridine synthase activity
A6F69_RS10775	COG0252	asparaginase activity
A6F69_RS10785	COG3118	belongs to the thioredoxin family
A6F69_RS10790	COG0165	Argininosuccinate lyase
A6F69_RS10800	COG0019	diaminopimelate decarboxylase activity
A6F69_RS10805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6F69_RS10805	COG1648	precorrin-2 dehydrogenase activity
A6F69_RS10820	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6F69_RS10825	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A6F69_RS10830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6F69_RS10835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6F69_RS10840	COG0297	glycogen (starch) synthase activity
A6F69_RS10850	COG1695	Transcriptional regulator
A6F69_RS10855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6F69_RS10875	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6F69_RS10895	COG2897	thiosulfate sulfurtransferase activity
A6F69_RS10900	COG0626	cystathionine gamma-synthase activity
A6F69_RS10905	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6F69_RS10905	COG3264	Mechanosensitive ion channel
A6F69_RS10910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6F69_RS10910	COG1648	precorrin-2 dehydrogenase activity
A6F69_RS10920	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6F69_RS10930	COG0175	sulfate reduction
A6F69_RS10945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6F69_RS10950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6F69_RS10955	COG4206	TonB-dependent receptor
A6F69_RS10965	COG0670	Belongs to the BI1 family
A6F69_RS10970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6F69_RS10985	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6F69_RS10990	COG0849	cell division
A6F69_RS10995	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6F69_RS11000	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6F69_RS11005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6F69_RS11010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6F69_RS11015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6F69_RS11025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6F69_RS11030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6F69_RS11040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6F69_RS11055	COG0275	rRNA processing
A6F69_RS11060	COG2001	Belongs to the MraZ family
A6F69_RS11075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6F69_RS11100	COG2154	pterin-4-alpha-carbinolamine dehydratase
A6F69_RS11105	COG4133	protoheme IX ABC transporter activity
A6F69_RS11110	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6F69_RS11120	COG0024	Methionine aminopeptidase
A6F69_RS11135	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6F69_RS11145	COG0174	glutamine synthetase
A6F69_RS11180	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A6F69_RS11185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6F69_RS11190	COG2084	Dehydrogenase
A6F69_RS11195	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A6F69_RS11205	COG0805	protein transport
A6F69_RS11210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6F69_RS11215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6F69_RS11220	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6F69_RS11225	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6F69_RS11230	COG1472	Belongs to the glycosyl hydrolase 3 family
A6F69_RS11240	COG0018	arginyl-trna synthetase
A6F69_RS11250	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6F69_RS11255	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6F69_RS11260	COG0328	RNA-DNA hybrid ribonuclease activity
A6F69_RS11265	COG3422	double-strand break repair
A6F69_RS11290	COG4964	Belongs to the GSP D family
A6F69_RS11320	COG1024	Enoyl-CoA hydratase
A6F69_RS11330	COG0183	Belongs to the thiolase family
A6F69_RS11345	COG4771	TonB-dependent receptor
A6F69_RS11350	COG0542	response to heat
A6F69_RS11375	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6F69_RS11380	COG0154	amidase activity
A6F69_RS11385	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6F69_RS11395	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6F69_RS11400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6F69_RS11405	COG0564	pseudouridine synthase activity
A6F69_RS11415	COG0546	phosphoglycolate phosphatase activity
A6F69_RS11435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6F69_RS11445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6F69_RS11450	COG0525	valine-tRNA ligase activity
A6F69_RS11470	COG0730	response to heat
A6F69_RS11475	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6F69_RS11495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6F69_RS11500	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A6F69_RS11515	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6F69_RS11530	COG0564	pseudouridine synthase activity
A6F69_RS11535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6F69_RS11580	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6F69_RS11585	COG1794	racemase activity, acting on amino acids and derivatives
A6F69_RS11595	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6F69_RS11600	COG0740	serine-type endopeptidase activity
A6F69_RS11610	COG0154	amidase activity
A6F69_RS11615	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6F69_RS11630	COG1160	GTP binding
A6F69_RS11660	COG2311	Membrane
A6F69_RS11680	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6F69_RS11685	COG0540	Belongs to the ATCase OTCase family
A6F69_RS11690	COG0616	signal peptide processing
A6F69_RS11695	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6F69_RS11705	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6F69_RS11720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6F69_RS11725	COG0432	Pfam Uncharacterised protein family UPF0047
A6F69_RS11735	COG1228	amidohydrolase
A6F69_RS11740	COG1609	Transcriptional regulator
A6F69_RS11745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6F69_RS11750	COG0129	dihydroxy-acid dehydratase activity
A6F69_RS11755	COG0837	glucose binding
A6F69_RS11760	COG0800	Aldolase
A6F69_RS11770	COG0037	tRNA processing
A6F69_RS11800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6F69_RS11815	COG0318	PFAM AMP-dependent synthetase and ligase
A6F69_RS11820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6F69_RS11830	COG1902	pentaerythritol trinitrate reductase activity
A6F69_RS11840	COG0321	lipoyl(octanoyl) transferase activity
A6F69_RS11865	COG4774	siderophore transport
A6F69_RS11870	COG2080	2 iron, 2 sulfur cluster binding
A6F69_RS11875	COG0534	Mate efflux family protein
A6F69_RS11880	COG2198	Histidine kinase
A6F69_RS11880	COG0643	Histidine kinase
A6F69_RS11890	COG0745	RESPONSE REGULATOR receiver
A6F69_RS11895	COG2201	protein-glutamate methylesterase activity
A6F69_RS11900	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6F69_RS11925	COG1115	amino acid carrier protein
A6F69_RS11935	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6F69_RS11940	COG4765	Protein conserved in bacteria
A6F69_RS11960	COG0318	PFAM AMP-dependent synthetase and ligase
A6F69_RS12000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6F69_RS12020	COG4771	TonB-dependent receptor
A6F69_RS12025	COG0596	Alpha beta hydrolase
A6F69_RS12025	COG2945	thiolester hydrolase activity
A6F69_RS12035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6F69_RS12045	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6F69_RS12045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F69_RS12055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F69_RS12085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6F69_RS12090	COG2010	Cytochrome c
A6F69_RS12090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6F69_RS12095	COG0489	protein tyrosine kinase activity
A6F69_RS12100	COG0330	HflC and HflK could
A6F69_RS12105	COG0330	HflC and HflK could
A6F69_RS12115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6F69_RS12120	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F69_RS12140	COG2813	Specifically methylates the guanine in position
A6F69_RS12140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F69_RS12145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F69_RS12150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6F69_RS12155	COG0287	Prephenate dehydrogenase
A6F69_RS12170	COG2177	Part of the ABC transporter FtsEX involved in
A6F69_RS12175	COG2884	Cell division ATP-binding protein ftsE
A6F69_RS12190	COG0745	RESPONSE REGULATOR receiver
A6F69_RS12220	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6F69_RS12225	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6F69_RS12245	COG0330	HflC and HflK could
A6F69_RS12270	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A6F69_RS12290	COG0527	aspartate kinase activity
A6F69_RS12295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6F69_RS12300	COG0584	glycerophosphoryl diester phosphodiesterase
A6F69_RS12305	COG1393	Belongs to the ArsC family
A6F69_RS12310	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6F69_RS12315	COG0217	transcriptional regulatory protein
A6F69_RS12330	COG0393	Putative heavy-metal-binding
A6F69_RS12335	COG3750	Belongs to the UPF0335 family
A6F69_RS12345	COG0469	pyruvate kinase activity
A6F69_RS12380	COG0668	transmembrane transport
A6F69_RS12405	COG0668	transmembrane transport
A6F69_RS12410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6F69_RS12415	COG4771	TonB-dependent receptor
A6F69_RS12420	COG0457	Tetratricopeptide repeat
A6F69_RS12490	COG1024	Enoyl-CoA hydratase
A6F69_RS12490	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6F69_RS12495	COG0436	Aminotransferase
A6F69_RS12500	COG3243	poly(R)-hydroxyalkanoic acid synthase
A6F69_RS12510	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6F69_RS12540	COG0784	Response regulator, receiver
A6F69_RS12545	COG3920	Histidine kinase
A6F69_RS12560	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6F69_RS12570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6F69_RS12575	COG3813	Protein conserved in bacteria
A6F69_RS12580	COG0352	thiamine-phosphate diphosphorylase activity
A6F69_RS12580	COG0351	phosphomethylpyrimidine kinase
A6F69_RS12580	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6F69_RS12585	COG1611	Belongs to the LOG family
A6F69_RS12605	COG0248	Ppx GppA phosphatase
A6F69_RS12610	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6F69_RS12615	COG3474	cytochrome
A6F69_RS12620	COG1605	Chorismate mutase
A6F69_RS12620	COG0077	Prephenate dehydratase
A6F69_RS12635	COG0714	Associated with various cellular activities
A6F69_RS12660	COG1446	asparaginase
A6F69_RS12700	COG1595	DNA-templated transcription, initiation
A6F69_RS12710	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6F69_RS12720	COG1971	Probably functions as a manganese efflux pump
A6F69_RS12725	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6F69_RS12745	COG2989	Protein conserved in bacteria
A6F69_RS12755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A6F69_RS12760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6F69_RS12770	COG2255	four-way junction helicase activity
A6F69_RS12785	COG0632	four-way junction helicase activity
A6F69_RS12790	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6F69_RS12800	COG0450	alkyl hydroperoxide reductase
A6F69_RS12810	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A6F69_RS12830	COG4395	Tim44
A6F69_RS12835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A6F69_RS12840	COG0728	peptidoglycan biosynthetic process
A6F69_RS12845	COG0180	Tryptophanyl-tRNA synthetase
A6F69_RS12855	COG0756	dUTP diphosphatase activity
A6F69_RS12860	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6F69_RS12870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6F69_RS12875	COG2226	methyltransferase
A6F69_RS12880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6F69_RS12885	COG0268	Binds directly to 16S ribosomal RNA