locus-tag	class	description
AM2010_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AM2010_RS00020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AM2010_RS00025	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AM2010_RS00035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AM2010_RS00050	COG0625	glutathione transferase activity
AM2010_RS00070	COG0714	Associated with various cellular activities
AM2010_RS00085	COG0077	Prephenate dehydratase
AM2010_RS00090	COG3474	cytochrome
AM2010_RS00095	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AM2010_RS00100	COG0248	Ppx GppA phosphatase
AM2010_RS00130	COG0358	DNA primase activity
AM2010_RS00225	COG1846	Transcriptional regulator
AM2010_RS00260	COG1629	transport
AM2010_RS00260	COG4771	TonB-dependent receptor
AM2010_RS00270	COG0352	thiamine-phosphate diphosphorylase activity
AM2010_RS00270	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AM2010_RS00270	COG0351	phosphomethylpyrimidine kinase
AM2010_RS00275	COG3813	Protein conserved in bacteria
AM2010_RS00280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AM2010_RS00305	COG3920	Histidine kinase
AM2010_RS00310	COG0784	Response regulator, receiver
AM2010_RS00315	COG0745	RESPONSE REGULATOR receiver
AM2010_RS00340	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AM2010_RS00350	COG3243	poly(R)-hydroxyalkanoic acid synthase
AM2010_RS00355	COG0436	Aminotransferase
AM2010_RS00360	COG0745	RESPONSE REGULATOR receiver
AM2010_RS00385	COG4771	TonB-dependent receptor
AM2010_RS00405	COG1120	ATPase activity
AM2010_RS00410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM2010_RS00455	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AM2010_RS00475	COG4786	Flagellar basal body rod
AM2010_RS00490	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AM2010_RS00495	COG1706	bacterial-type flagellum-dependent cell motility
AM2010_RS00505	COG1256	bacterial-type flagellum assembly
AM2010_RS00505	COG4786	Flagellar basal body rod
AM2010_RS00510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AM2010_RS00520	COG1360	Flagellar Motor Protein
AM2010_RS00550	COG0318	PFAM AMP-dependent synthetase and ligase
AM2010_RS00570	COG4765	Protein conserved in bacteria
AM2010_RS00575	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AM2010_RS00585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AM2010_RS00590	COG1522	sequence-specific DNA binding
AM2010_RS00605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AM2010_RS00630	COG1482	cell wall glycoprotein biosynthetic process
AM2010_RS00645	COG1677	Flagellar hook-basal body complex protein FliE
AM2010_RS00655	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AM2010_RS00705	COG1987	bacterial-type flagellum assembly
AM2010_RS00710	COG1684	flagellar biosynthetic protein fliR
AM2010_RS00730	COG4566	intracellular signal transduction
AM2010_RS00750	COG0783	Belongs to the Dps family
AM2010_RS00760	COG0494	nUDIX hydrolase
AM2010_RS00775	COG4770	biotin carboxylase activity
AM2010_RS00790	COG2852	Protein conserved in bacteria
AM2010_RS00810	COG4946	Tricorn protease homolog
AM2010_RS00810	COG1506	peptidase
AM2010_RS00810	COG0823	Involved in the tonB-independent uptake of proteins
AM2010_RS00830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AM2010_RS00860	COG1671	Belongs to the UPF0178 family
AM2010_RS00890	COG1278	Cold shock
AM2010_RS00945	COG2171	N-acyltransferase activity
AM2010_RS00955	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AM2010_RS00965	COG2211	Major facilitator Superfamily
AM2010_RS00970	COG1960	acyl-CoA dehydrogenase activity
AM2010_RS00975	COG1960	acyl-CoA dehydrogenase activity
AM2010_RS00985	COG0194	GDP metabolic process
AM2010_RS01000	COG0131	Imidazoleglycerol-phosphate dehydratase
AM2010_RS01005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AM2010_RS01010	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AM2010_RS01015	COG0107	imidazoleglycerol-phosphate synthase activity
AM2010_RS01025	COG3665	Urea carboxylase-associated protein
AM2010_RS01045	COG1082	Xylose isomerase domain protein TIM barrel
AM2010_RS01050	COG3119	arylsulfatase activity
AM2010_RS01075	COG2723	6-phospho-beta-galactosidase activity
AM2010_RS01085	COG0395	ABC-type sugar transport system, permease component
AM2010_RS01090	COG1175	transmembrane transport
AM2010_RS01095	COG1653	transport
AM2010_RS01110	COG0840	transmembrane signaling receptor activity
AM2010_RS01115	COG5001	Diguanylate cyclase
AM2010_RS01125	COG2201	protein-glutamate methylesterase activity
AM2010_RS01130	COG0745	RESPONSE REGULATOR receiver
AM2010_RS01140	COG0643	Histidine kinase
AM2010_RS01140	COG2198	Histidine kinase
AM2010_RS01150	COG2080	2 iron, 2 sulfur cluster binding
AM2010_RS01155	COG4774	siderophore transport
AM2010_RS01180	COG0321	lipoyl(octanoyl) transferase activity
AM2010_RS01190	COG1902	pentaerythritol trinitrate reductase activity
AM2010_RS01225	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AM2010_RS01240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM2010_RS01255	COG0037	tRNA processing
AM2010_RS01265	COG0800	Aldolase
AM2010_RS01270	COG0129	dihydroxy-acid dehydratase activity
AM2010_RS01275	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AM2010_RS01280	COG1609	Transcriptional regulator
AM2010_RS01290	COG0837	glucose binding
AM2010_RS01300	COG0432	Pfam Uncharacterised protein family UPF0047
AM2010_RS01325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AM2010_RS01350	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AM2010_RS01355	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AM2010_RS01365	COG4771	TonB-dependent receptor
AM2010_RS01370	COG1309	transcriptional regulator
AM2010_RS01375	COG0488	(ABC) transporter
AM2010_RS01395	COG0811	peptide transport
AM2010_RS01420	COG3210	domain, Protein
AM2010_RS01465	COG1741	Belongs to the pirin family
AM2010_RS01480	COG0753	catalase activity
AM2010_RS01490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM2010_RS01490	COG3453	Protein conserved in bacteria
AM2010_RS01515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM2010_RS01545	COG0616	signal peptide processing
AM2010_RS01550	COG0540	Belongs to the ATCase OTCase family
AM2010_RS01555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AM2010_RS01580	COG2311	Membrane
AM2010_RS01590	COG2193	ferroxidase activity
AM2010_RS01600	COG1160	GTP binding
AM2010_RS01625	COG0544	peptidyl-prolyl cis-trans isomerase activity
AM2010_RS01635	COG0740	serine-type endopeptidase activity
AM2010_RS01640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AM2010_RS01650	COG1028	Short-chain dehydrogenase reductase Sdr
AM2010_RS01665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM2010_RS01670	COG0564	pseudouridine synthase activity
AM2010_RS01685	COG3023	N-Acetylmuramoyl-L-alanine amidase
AM2010_RS01690	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AM2010_RS01695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AM2010_RS01715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AM2010_RS01720	COG1215	transferase activity, transferring glycosyl groups
AM2010_RS01730	COG0730	response to heat
AM2010_RS01750	COG0525	valine-tRNA ligase activity
AM2010_RS01755	COG0525	valine-tRNA ligase activity
AM2010_RS01760	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AM2010_RS01790	COG0546	phosphoglycolate phosphatase activity
AM2010_RS01800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AM2010_RS01810	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AM2010_RS01820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AM2010_RS01825	COG0154	amidase activity
AM2010_RS01835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AM2010_RS01845	COG0612	Peptidase, M16
AM2010_RS01855	COG0542	response to heat
AM2010_RS01875	COG4206	TonB-dependent receptor
AM2010_RS01880	COG0183	Belongs to the thiolase family
AM2010_RS01890	COG1024	Enoyl-CoA hydratase
AM2010_RS01920	COG4964	Belongs to the GSP D family
AM2010_RS01945	COG0328	RNA-DNA hybrid ribonuclease activity
AM2010_RS01950	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AM2010_RS01955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AM2010_RS01965	COG0018	arginyl-trna synthetase
AM2010_RS01975	COG1472	Belongs to the glycosyl hydrolase 3 family
AM2010_RS01980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AM2010_RS01985	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AM2010_RS01990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AM2010_RS01995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AM2010_RS02000	COG0805	protein transport
AM2010_RS02015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AM2010_RS02020	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AM2010_RS02025	COG0729	surface antigen
AM2010_RS02040	COG0174	glutamine synthetase
AM2010_RS02045	COG0347	Belongs to the P(II) protein family
AM2010_RS02060	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AM2010_RS02070	COG0024	Methionine aminopeptidase
AM2010_RS02080	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AM2010_RS02090	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AM2010_RS02095	COG4133	protoheme IX ABC transporter activity
AM2010_RS02100	COG2154	pterin-4-alpha-carbinolamine dehydratase
AM2010_RS02125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AM2010_RS02140	COG2001	Belongs to the MraZ family
AM2010_RS02145	COG0275	rRNA processing
AM2010_RS02160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AM2010_RS02165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AM2010_RS02170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AM2010_RS02175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AM2010_RS02185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AM2010_RS02190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AM2010_RS02195	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AM2010_RS02200	COG1181	Belongs to the D-alanine--D-alanine ligase family
AM2010_RS02205	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AM2010_RS02210	COG0849	cell division
AM2010_RS02230	COG0670	Belongs to the BI1 family
AM2010_RS02245	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AM2010_RS02250	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AM2010_RS02255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM2010_RS02260	COG0175	sulfate reduction
AM2010_RS02280	COG1648	precorrin-2 dehydrogenase activity
AM2010_RS02280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AM2010_RS02285	COG1196	nuclear chromosome segregation
AM2010_RS02285	COG3264	Mechanosensitive ion channel
AM2010_RS02290	COG0626	cystathionine gamma-synthase activity
AM2010_RS02295	COG2897	thiosulfate sulfurtransferase activity
AM2010_RS02300	COG0024	Methionine aminopeptidase
AM2010_RS02310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM2010_RS02315	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AM2010_RS02335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM2010_RS02345	COG0405	Gamma-glutamyltransferase
AM2010_RS02355	COG1301	dicarboxylic acid transport
AM2010_RS02360	COG4206	TonB-dependent receptor
AM2010_RS02365	COG0583	DNA-binding transcription factor activity
AM2010_RS02375	COG0625	glutathione transferase activity
AM2010_RS02385	COG1058	Belongs to the CinA family
AM2010_RS02385	COG1546	Belongs to the CinA family
AM2010_RS02400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AM2010_RS02410	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AM2010_RS02415	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AM2010_RS02425	COG1381	Involved in DNA repair and RecF pathway recombination
AM2010_RS02430	COG0473	3-isopropylmalate dehydrogenase activity
AM2010_RS02455	COG2967	ApaG domain
AM2010_RS02460	COG0248	Ppx GppA phosphatase
AM2010_RS02465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AM2010_RS02485	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AM2010_RS02490	COG0049	tRNA binding
AM2010_RS02495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AM2010_RS02500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AM2010_RS02505	COG0051	transcription antitermination factor activity, RNA binding
AM2010_RS02510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AM2010_RS02515	COG0088	Forms part of the polypeptide exit tunnel
AM2010_RS02520	COG0089	rRNA binding
AM2010_RS02525	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AM2010_RS02530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AM2010_RS02535	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AM2010_RS02540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AM2010_RS02545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AM2010_RS02550	COG0255	Belongs to the universal ribosomal protein uL29 family
AM2010_RS02555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AM2010_RS02560	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AM2010_RS02565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AM2010_RS02570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AM2010_RS02575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AM2010_RS02580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AM2010_RS02585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AM2010_RS02590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AM2010_RS02595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AM2010_RS02600	COG1841	ribosomal large subunit assembly
AM2010_RS02605	COG0200	Binds to the 23S rRNA
AM2010_RS02610	COG0201	protein transport
AM2010_RS02615	COG0563	adenylate kinase activity
AM2010_RS02625	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AM2010_RS02630	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AM2010_RS02635	COG0202	RNA polymerase activity
AM2010_RS02640	COG0203	ribosomal protein L17
AM2010_RS02650	COG1505	serine-type exopeptidase activity
AM2010_RS02665	COG2860	membrane
AM2010_RS02680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM2010_RS02690	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM2010_RS02705	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AM2010_RS02710	COG0039	L-malate dehydrogenase activity
AM2010_RS02715	COG5001	Diguanylate cyclase
AM2010_RS02715	COG3300	MHYT domain
AM2010_RS02735	COG0339	signal peptide processing
AM2010_RS02740	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AM2010_RS02750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AM2010_RS02770	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AM2010_RS02775	COG0137	argininosuccinate synthase activity
AM2010_RS02780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AM2010_RS02785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AM2010_RS02790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AM2010_RS02795	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
AM2010_RS02810	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AM2010_RS02815	COG1733	regulation of RNA biosynthetic process
AM2010_RS02820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AM2010_RS02830	COG3682	Transcriptional regulator
AM2010_RS02850	COG1028	Short-chain dehydrogenase reductase Sdr
AM2010_RS02870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AM2010_RS02870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AM2010_RS02880	COG1051	belongs to the nudix hydrolase family
AM2010_RS02885	COG0657	acetylesterase activity
AM2010_RS02890	COG0674	pyruvate-flavodoxin oxidoreductase activity
AM2010_RS02890	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AM2010_RS02895	COG1013	pyruvate-flavodoxin oxidoreductase activity
AM2010_RS02905	COG0671	phosphoesterase, PA-phosphatase related
AM2010_RS02910	COG0415	Belongs to the DNA photolyase family
AM2010_RS02920	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AM2010_RS02935	COG1028	Short-chain dehydrogenase reductase Sdr
AM2010_RS02940	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AM2010_RS02945	COG4591	ABC-type transport system involved in lipoprotein release permease component
AM2010_RS02950	COG1136	(ABC) transporter
AM2010_RS02960	COG0386	Belongs to the glutathione peroxidase family
AM2010_RS02975	COG0318	PFAM AMP-dependent synthetase and ligase
AM2010_RS02995	COG1012	belongs to the aldehyde dehydrogenase family
AM2010_RS03000	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AM2010_RS03050	COG0789	Transcriptional regulator
AM2010_RS03065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AM2010_RS03070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AM2010_RS03080	COG0640	Transcriptional regulator
AM2010_RS03105	COG0668	transmembrane transport
AM2010_RS03110	COG2003	Belongs to the UPF0758 family
AM2010_RS03135	COG0356	it plays a direct role in the translocation of protons across the membrane
AM2010_RS03140	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AM2010_RS03145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AM2010_RS03150	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AM2010_RS03160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM2010_RS03165	COG0539	negative regulation of cytoplasmic translation
AM2010_RS03170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AM2010_RS03180	COG2076	Multidrug Resistance protein
AM2010_RS03185	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AM2010_RS03200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AM2010_RS03205	COG0228	four-way junction DNA binding
AM2010_RS03210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AM2010_RS03215	COG0336	Belongs to the RNA methyltransferase TrmD family
AM2010_RS03220	COG0335	large ribosomal subunit rRNA binding
AM2010_RS03225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AM2010_RS03240	COG2267	carboxylic ester hydrolase activity
AM2010_RS03250	COG4067	protein conserved in archaea
AM2010_RS03250	COG0189	ligase activity
AM2010_RS03255	COG0189	ligase activity
AM2010_RS03260	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AM2010_RS03265	COG0359	binds to the 23S rRNA
AM2010_RS03270	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AM2010_RS03275	COG0360	Binds together with S18 to 16S ribosomal RNA
AM2010_RS03280	COG2354	Protein conserved in bacteria
AM2010_RS03285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AM2010_RS03295	COG0504	CTP synthase activity
AM2010_RS03300	COG0071	Belongs to the small heat shock protein (HSP20) family
AM2010_RS03310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM2010_RS03330	COG1199	ATP-dependent helicase activity
AM2010_RS03330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM2010_RS03375	COG4948	Mandelate Racemase Muconate Lactonizing
AM2010_RS03380	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AM2010_RS03385	COG4771	TonB-dependent receptor
AM2010_RS03405	COG2205	protein histidine kinase activity
AM2010_RS03410	COG1522	sequence-specific DNA binding
AM2010_RS03420	COG0439	Biotin carboxylase
AM2010_RS03425	COG0511	ligase activity, forming carbon-carbon bonds
AM2010_RS03435	COG4115	mRNA cleavage
AM2010_RS03440	COG2161	toxin-antitoxin pair type II binding
AM2010_RS03450	COG2301	Belongs to the HpcH HpaI aldolase family
AM2010_RS03470	COG1862	Preprotein translocase
AM2010_RS03475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM2010_RS03480	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM2010_RS03485	COG0438	transferase activity, transferring glycosyl groups
AM2010_RS03515	COG0488	(ABC) transporter
AM2010_RS03520	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AM2010_RS03545	COG1605	Chorismate mutase
AM2010_RS03545	COG0287	Prephenate dehydrogenase
AM2010_RS03550	COG0142	geranyltranstransferase activity
AM2010_RS03555	COG1643	Atp-dependent helicase
AM2010_RS03575	COG0235	Class ii aldolase
AM2010_RS03585	COG0776	regulation of translation
AM2010_RS03665	COG0688	phosphatidylethanolamine metabolic process
AM2010_RS03675	COG0052	Belongs to the universal ribosomal protein uS2 family
AM2010_RS03680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AM2010_RS03685	COG0528	UMP kinase activity
AM2010_RS03690	COG0233	cytoplasmic translational termination
AM2010_RS03695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AM2010_RS03705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AM2010_RS03710	COG0750	zinc metalloprotease
AM2010_RS03715	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM2010_RS03725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AM2010_RS03730	COG0254	rRNA binding
AM2010_RS03745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AM2010_RS03750	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AM2010_RS03755	COG1138	Cytochrome C-type biogenesis protein
AM2010_RS03760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AM2010_RS03765	COG3088	subunit of a heme lyase
AM2010_RS03775	COG3158	transport of potassium into the cell
AM2010_RS03780	COG2917	probably involved in intracellular septation
AM2010_RS03785	COG0552	protein localization to endoplasmic reticulum
AM2010_RS03790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AM2010_RS03795	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AM2010_RS03800	COG5001	Diguanylate cyclase
AM2010_RS03800	COG3300	MHYT domain
AM2010_RS03825	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AM2010_RS03830	COG1192	Involved in chromosome partitioning
AM2010_RS03835	COG0583	DNA-binding transcription factor activity
AM2010_RS03840	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AM2010_RS03845	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AM2010_RS03855	COG2199	diguanylate cyclase activity
AM2010_RS03865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AM2010_RS03870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AM2010_RS03875	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AM2010_RS03905	COG3387	PFAM Glycoside hydrolase 15-related
AM2010_RS03910	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AM2010_RS03915	COG2365	Tyrosine phosphatase family
AM2010_RS03935	COG2226	methyltransferase
AM2010_RS03950	COG1748	Saccharopine dehydrogenase
AM2010_RS03970	COG0745	RESPONSE REGULATOR receiver
AM2010_RS03975	COG0704	Plays a role in the regulation of phosphate uptake
AM2010_RS03980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AM2010_RS03990	COG0573	inorganic phosphate transmembrane transporter activity
AM2010_RS03995	COG5002	protein histidine kinase activity
AM2010_RS04010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AM2010_RS04035	COG3618	amidohydrolase
AM2010_RS04040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AM2010_RS04045	COG2353	YceI-like domain
AM2010_RS04050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AM2010_RS04060	COG0028	Belongs to the TPP enzyme family
AM2010_RS04065	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AM2010_RS04070	COG3830	Belongs to the UPF0237 family
AM2010_RS04070	COG0560	Phosphoserine phosphatase
AM2010_RS04085	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AM2010_RS04095	COG1722	exodeoxyribonuclease VII activity
AM2010_RS04100	COG0142	geranyltranstransferase activity
AM2010_RS04105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AM2010_RS04115	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AM2010_RS04120	COG2843	Capsule synthesis protein
AM2010_RS04130	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AM2010_RS04135	COG1131	(ABC) transporter
AM2010_RS04140	COG0842	Transport permease protein
AM2010_RS04150	COG0343	queuine tRNA-ribosyltransferase activity
AM2010_RS04155	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AM2010_RS04170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AM2010_RS04175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AM2010_RS04180	COG0698	ribose 5-phosphate isomerase
AM2010_RS04185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM2010_RS04190	COG0358	DNA primase activity
AM2010_RS04200	COG0505	Belongs to the CarA family
AM2010_RS04215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM2010_RS04245	COG0148	phosphopyruvate hydratase activity
AM2010_RS04255	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AM2010_RS04265	COG0772	Belongs to the SEDS family
AM2010_RS04280	COG1792	Involved in formation and maintenance of cell shape
AM2010_RS04290	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AM2010_RS04330	COG0012	GTP binding
AM2010_RS04335	COG0193	aminoacyl-tRNA hydrolase activity
AM2010_RS04340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM2010_RS04345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AM2010_RS04360	COG0752	glycyl-tRNA synthetase alpha subunit
AM2010_RS04365	COG0751	glycine-tRNA ligase activity
AM2010_RS04370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM2010_RS04370	COG0574	Belongs to the PEP-utilizing enzyme family
AM2010_RS04380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AM2010_RS04385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AM2010_RS04390	COG0789	Transcriptional regulator
AM2010_RS04395	COG1960	acyl-CoA dehydrogenase activity
AM2010_RS04430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AM2010_RS04440	COG3876	Protein conserved in bacteria
AM2010_RS04445	COG2814	Major facilitator Superfamily
AM2010_RS04450	COG3739	integral membrane protein
AM2010_RS04470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM2010_RS04495	COG0187	DNA topoisomerase II activity
AM2010_RS04505	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AM2010_RS04510	COG0792	nuclease activity
AM2010_RS04515	COG0189	ligase activity
AM2010_RS04520	COG0586	Pfam SNARE associated Golgi protein
AM2010_RS04525	COG4974	Belongs to the 'phage' integrase family
AM2010_RS04530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AM2010_RS04535	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AM2010_RS04540	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AM2010_RS04545	COG1420	regulation of RNA biosynthetic process
AM2010_RS04550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AM2010_RS04580	COG0443	Heat shock 70 kDa protein
AM2010_RS04585	COG0484	heat shock protein binding
AM2010_RS04590	COG1752	Esterase of the alpha-beta hydrolase superfamily
AM2010_RS04615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AM2010_RS04625	COG0442	prolyl-tRNA aminoacylation
AM2010_RS04630	COG2234	aminopeptidase activity
AM2010_RS04635	COG0557	exoribonuclease II activity
AM2010_RS04655	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM2010_RS04670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM2010_RS04690	COG4206	TonB-dependent receptor
AM2010_RS04695	COG0612	Peptidase, M16
AM2010_RS04725	COG4771	TonB-dependent receptor
AM2010_RS04755	COG0183	Belongs to the thiolase family
AM2010_RS04780	COG1234	tRNA 3'-trailer cleavage
AM2010_RS04790	COG2951	lytic endotransglycosylase activity
AM2010_RS04800	COG1686	Belongs to the peptidase S11 family
AM2010_RS04805	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AM2010_RS04810	COG0470	DNA polymerase III
AM2010_RS04820	COG0084	hydrolase, TatD family'
AM2010_RS04825	COG0321	lipoyl(octanoyl) transferase activity
AM2010_RS04825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AM2010_RS04830	COG3956	TIGRFAM MazG family protein
AM2010_RS04835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AM2010_RS04840	COG1923	regulation of RNA biosynthetic process
AM2010_RS04845	COG2204	response regulator
AM2010_RS04850	COG5000	phosphorelay sensor kinase activity
AM2010_RS04855	COG2204	response regulator
AM2010_RS04860	COG3852	Histidine kinase
AM2010_RS04870	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AM2010_RS04870	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AM2010_RS04880	COG1546	Belongs to the CinA family
AM2010_RS04880	COG1058	Belongs to the CinA family
AM2010_RS04885	COG2867	negative regulation of translational initiation
AM2010_RS04890	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AM2010_RS04910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AM2010_RS04920	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AM2010_RS04965	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM2010_RS04965	COG0022	dehydrogenase e1 component
AM2010_RS04970	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AM2010_RS04990	COG3264	Mechanosensitive ion channel
AM2010_RS04990	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AM2010_RS05020	COG0825	malonyl-CoA metabolic process
AM2010_RS05025	COG4974	Belongs to the 'phage' integrase family
AM2010_RS05035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AM2010_RS05040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AM2010_RS05050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM2010_RS05055	COG4770	biotin carboxylase activity
AM2010_RS05060	COG3755	Protein conserved in bacteria
AM2010_RS05070	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AM2010_RS05080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AM2010_RS05080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AM2010_RS05085	COG1024	Enoyl-CoA hydratase
AM2010_RS05090	COG0346	lactoylglutathione lyase activity
AM2010_RS05095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AM2010_RS05105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AM2010_RS05110	COG0513	Belongs to the DEAD box helicase family
AM2010_RS05125	COG0166	Belongs to the GPI family
AM2010_RS05130	COG0681	Belongs to the peptidase S26 family
AM2010_RS05135	COG0571	ribonuclease III activity
AM2010_RS05140	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AM2010_RS05150	COG1754	DNA topoisomerase type I activity
AM2010_RS05150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AM2010_RS05160	COG0758	DNA mediated transformation
AM2010_RS05165	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AM2010_RS05170	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AM2010_RS05175	COG0156	8-amino-7-oxononanoate synthase activity
AM2010_RS05185	COG0733	neurotransmitter:sodium symporter activity
AM2010_RS05190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AM2010_RS05200	COG0385	Bile acid
AM2010_RS05210	COG2204	response regulator
AM2010_RS05215	COG0784	Response regulator, receiver
AM2010_RS05215	COG2205	protein histidine kinase activity
AM2010_RS05220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AM2010_RS05255	COG0483	inositol monophosphate 1-phosphatase activity
AM2010_RS05265	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AM2010_RS05280	COG0352	thiamine-phosphate diphosphorylase activity
AM2010_RS05290	COG3588	fructose-bisphosphate aldolase
AM2010_RS05305	COG0126	phosphoglycerate kinase activity
AM2010_RS05310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AM2010_RS05330	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AM2010_RS05365	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AM2010_RS05375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AM2010_RS05380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AM2010_RS05390	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AM2010_RS05400	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AM2010_RS05415	COG0653	protein targeting
AM2010_RS05425	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AM2010_RS05430	COG0483	inositol monophosphate 1-phosphatase activity
AM2010_RS05440	COG1074	ATP-dependent DNA helicase activity
AM2010_RS05445	COG2887	Belongs to the helicase family. UvrD subfamily
AM2010_RS05450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AM2010_RS05455	COG3178	'Phosphotransferase
AM2010_RS05460	COG0802	atpase or kinase
AM2010_RS05465	COG2205	protein histidine kinase activity
AM2010_RS05470	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AM2010_RS05475	COG0678	peroxiredoxin activity
AM2010_RS05475	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM2010_RS05480	COG1607	acyl-coa hydrolase
AM2010_RS05485	COG0302	gtp cyclohydrolase
AM2010_RS05510	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AM2010_RS05530	COG1733	regulation of RNA biosynthetic process
AM2010_RS05540	COG0625	glutathione transferase activity
AM2010_RS05545	COG5507	3-demethylubiquinone-9 3-methyltransferase
AM2010_RS05550	COG5507	3-demethylubiquinone-9 3-methyltransferase
AM2010_RS05595	COG1741	Belongs to the pirin family
AM2010_RS05600	COG1028	Short-chain dehydrogenase reductase Sdr
AM2010_RS05605	COG0596	Alpha beta hydrolase
AM2010_RS05610	COG4206	TonB-dependent receptor
AM2010_RS05620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AM2010_RS05625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AM2010_RS05630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AM2010_RS05635	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AM2010_RS05650	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AM2010_RS05670	COG2202	Pas domain
AM2010_RS05670	COG2200	EAL domain
AM2010_RS05670	COG2199	diguanylate cyclase activity
AM2010_RS05680	COG0322	excinuclease ABC activity
AM2010_RS05685	COG2081	HI0933 family
AM2010_RS05695	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AM2010_RS05700	COG0424	maF-like protein
AM2010_RS05745	COG0481	GTPase activity
AM2010_RS05750	COG3300	MHYT domain
AM2010_RS05750	COG5001	Diguanylate cyclase
AM2010_RS05755	COG0493	'glutamate synthase
AM2010_RS05775	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AM2010_RS05785	COG0149	triose-phosphate isomerase activity
AM2010_RS05795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AM2010_RS05800	COG3698	Phosphodiester glycosidase
AM2010_RS05815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AM2010_RS05820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AM2010_RS05835	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AM2010_RS05840	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AM2010_RS05845	COG2133	pyrroloquinoline quinone binding
AM2010_RS05865	COG0617	tRNA 3'-terminal CCA addition
AM2010_RS05875	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AM2010_RS05880	COG0693	protein deglycase activity
AM2010_RS05890	COG0596	Alpha beta hydrolase
AM2010_RS05900	COG1104	cysteine desulfurase activity
AM2010_RS05905	COG1104	cysteine desulfurase activity
AM2010_RS05910	COG2945	thiolester hydrolase activity
AM2010_RS05940	COG0750	zinc metalloprotease
AM2010_RS05955	COG0277	FAD linked oxidase domain protein
AM2010_RS05980	COG0538	isocitrate dehydrogenase activity
AM2010_RS05985	COG3153	acetyltransferase
AM2010_RS05985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM2010_RS06005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AM2010_RS06010	COG4106	trans-aconitate 2-methyltransferase activity
AM2010_RS06015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AM2010_RS06040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AM2010_RS06050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM2010_RS06055	COG0741	lytic transglycosylase activity
AM2010_RS06075	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AM2010_RS06085	COG0284	orotidine-5'-phosphate decarboxylase activity
AM2010_RS06100	COG0133	tryptophan synthase activity
AM2010_RS06105	COG0159	tryptophan synthase activity
AM2010_RS06110	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AM2010_RS06115	COG0285	dihydrofolate synthase activity
AM2010_RS06120	COG2223	nitrite transmembrane transporter activity
AM2010_RS06125	COG4638	Rieske (2fe-2S)
AM2010_RS06130	COG1187	pseudouridine synthase activity
AM2010_RS06135	COG0742	ribosomal rna small subunit methyltransferase
AM2010_RS06150	COG0210	DNA helicase
AM2010_RS06160	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AM2010_RS06165	COG0745	RESPONSE REGULATOR receiver
AM2010_RS06170	COG0642	Histidine kinase
AM2010_RS06175	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AM2010_RS06180	COG1660	Displays ATPase and GTPase activities
AM2010_RS06195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM2010_RS06210	COG1322	Protein conserved in bacteria
AM2010_RS06215	COG0242	peptide deformylase activity
AM2010_RS06220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AM2010_RS06225	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AM2010_RS06235	COG0101	tRNA pseudouridine synthase activity
AM2010_RS06245	COG0252	asparaginase activity
AM2010_RS06260	COG2207	Transcriptional regulator
AM2010_RS06260	COG1917	Cupin 2, conserved barrel domain protein
AM2010_RS06275	COG4771	TonB-dependent receptor
AM2010_RS06290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AM2010_RS06295	COG0165	Argininosuccinate lyase
AM2010_RS06305	COG0019	diaminopimelate decarboxylase activity
AM2010_RS06310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AM2010_RS06310	COG1648	precorrin-2 dehydrogenase activity
AM2010_RS06320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AM2010_RS06330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM2010_RS06335	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AM2010_RS06350	COG1695	Transcriptional regulator
AM2010_RS06355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AM2010_RS06370	COG0114	fumarate hydratase activity
AM2010_RS06375	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AM2010_RS06415	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AM2010_RS06420	COG1794	racemase activity, acting on amino acids and derivatives
AM2010_RS06465	COG0134	indole-3-glycerol-phosphate synthase activity
AM2010_RS06470	COG0315	cyclic pyranopterin monophosphate synthase activity
AM2010_RS06480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AM2010_RS06485	COG2333	competence protein COMEC
AM2010_RS06485	COG0658	competence protein
AM2010_RS06490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AM2010_RS06495	COG0372	Belongs to the citrate synthase family
AM2010_RS06540	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AM2010_RS06550	COG1007	ATP synthesis coupled electron transport
AM2010_RS06565	COG0713	ATP synthesis coupled electron transport
AM2010_RS06575	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM2010_RS06580	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AM2010_RS06595	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AM2010_RS06600	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AM2010_RS06605	COG0649	NAD binding
AM2010_RS06610	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM2010_RS06615	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM2010_RS06620	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM2010_RS06625	COG1012	belongs to the aldehyde dehydrogenase family
AM2010_RS06630	COG0183	Belongs to the thiolase family
AM2010_RS06645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM2010_RS06650	COG0004	ammonium transporteR
AM2010_RS06660	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AM2010_RS06670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AM2010_RS06675	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AM2010_RS06685	COG1530	ribonuclease E activity
AM2010_RS06700	COG1181	Belongs to the D-alanine--D-alanine ligase family
AM2010_RS06715	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AM2010_RS06720	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM2010_RS06720	COG1024	Enoyl-CoA hydratase
AM2010_RS06725	COG0367	asparagine synthase
AM2010_RS06745	COG0726	polysaccharide deacetylase
AM2010_RS06750	COG3267	Type II secretory pathway component ExeA
AM2010_RS06750	COG3409	Peptidoglycan-binding domain 1 protein
AM2010_RS06790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AM2010_RS06805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AM2010_RS06810	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AM2010_RS06810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AM2010_RS06820	COG0129	dihydroxy-acid dehydratase activity
AM2010_RS06830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AM2010_RS06850	COG0521	Mo-molybdopterin cofactor biosynthetic process
AM2010_RS06865	COG0418	dihydroorotase activity
AM2010_RS06890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM2010_RS06895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AM2010_RS06900	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AM2010_RS06910	COG0314	molybdopterin synthase activity
AM2010_RS06920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AM2010_RS06975	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AM2010_RS06985	COG0109	protoheme IX farnesyltransferase activity
AM2010_RS06990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AM2010_RS06995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AM2010_RS07000	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AM2010_RS07005	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AM2010_RS07010	COG0736	holo-[acyl-carrier-protein] synthase activity
AM2010_RS07015	COG0681	Belongs to the peptidase S26 family
AM2010_RS07030	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AM2010_RS07065	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AM2010_RS07075	COG1028	Short-chain dehydrogenase reductase Sdr
AM2010_RS07080	COG2264	protein methyltransferase activity
AM2010_RS07095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AM2010_RS07110	COG0497	DNA recombination
AM2010_RS07115	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM2010_RS07120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AM2010_RS07125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AM2010_RS07130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AM2010_RS07135	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AM2010_RS07145	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AM2010_RS07150	COG0047	phosphoribosylformylglycinamidine synthase activity
AM2010_RS07155	COG5001	Diguanylate cyclase
AM2010_RS07195	COG2132	Multicopper oxidase
AM2010_RS07200	COG1937	Protein conserved in bacteria
AM2010_RS07235	COG0789	Transcriptional regulator
AM2010_RS07340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AM2010_RS07360	COG0668	transmembrane transport
AM2010_RS07365	COG0745	RESPONSE REGULATOR receiver
AM2010_RS07375	COG5002	protein histidine kinase activity
AM2010_RS07410	COG2816	NAD+ diphosphatase activity
AM2010_RS07445	COG1196	nuclear chromosome segregation
AM2010_RS07465	COG0776	regulation of translation
AM2010_RS07470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AM2010_RS07475	COG0416	fatty acid biosynthetic process
AM2010_RS07480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AM2010_RS07490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM2010_RS07510	COG1012	belongs to the aldehyde dehydrogenase family
AM2010_RS07515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AM2010_RS07520	COG0215	cysteine-tRNA ligase activity
AM2010_RS07545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AM2010_RS07560	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AM2010_RS07565	COG2169	Transcriptional regulator
AM2010_RS07565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM2010_RS07580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AM2010_RS07585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AM2010_RS07590	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AM2010_RS07600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AM2010_RS07605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AM2010_RS07610	COG0116	Belongs to the methyltransferase superfamily
AM2010_RS07610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AM2010_RS07625	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AM2010_RS07630	COG0546	phosphoglycolate phosphatase activity
AM2010_RS07635	COG1028	Short-chain dehydrogenase reductase Sdr
AM2010_RS07645	COG1045	serine acetyltransferase
AM2010_RS07660	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AM2010_RS07665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AM2010_RS07670	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AM2010_RS07675	COG0612	Peptidase, M16
AM2010_RS07680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AM2010_RS07685	COG0778	Nitroreductase
AM2010_RS07700	COG4957	zinc ion binding
AM2010_RS07710	COG0204	Acyl-transferase
AM2010_RS07715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AM2010_RS07725	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AM2010_RS07730	COG1253	flavin adenine dinucleotide binding
AM2010_RS07735	COG0583	DNA-binding transcription factor activity
AM2010_RS07750	COG2239	Acts as a magnesium transporter
AM2010_RS07825	COG0842	Transport permease protein
AM2010_RS07835	COG1988	membrane-bound metal-dependent
AM2010_RS07840	COG0725	ABC transporter, periplasmic molybdate-binding protein
AM2010_RS07845	COG4149	molybdate abc transporter
AM2010_RS07865	COG1185	polyribonucleotide nucleotidyltransferase activity
AM2010_RS07870	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AM2010_RS07875	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AM2010_RS07880	COG1994	Peptidase M50
AM2010_RS07885	COG1435	thymidine kinase activity
AM2010_RS07895	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AM2010_RS07900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AM2010_RS07905	COG0505	Belongs to the CarA family
AM2010_RS07910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AM2010_RS07925	COG0779	Required for maturation of 30S ribosomal subunits
AM2010_RS07930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM2010_RS07935	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AM2010_RS07940	COG1842	Phage shock protein A
AM2010_RS07980	COG2166	iron-sulfur cluster assembly
AM2010_RS08000	COG0824	Thioesterase
AM2010_RS08005	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AM2010_RS08020	COG0066	3-isopropylmalate dehydratase activity
AM2010_RS08040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AM2010_RS08055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM2010_RS08060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM2010_RS08070	COG1573	uracil-dna glycosylase
AM2010_RS08090	COG4771	TonB-dependent receptor
AM2010_RS08095	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
AM2010_RS08115	COG3451	type IV secretory pathway VirB4
AM2010_RS08130	COG1196	nuclear chromosome segregation
AM2010_RS08130	COG0739	heme binding
AM2010_RS08130	COG0741	lytic transglycosylase activity
AM2010_RS08150	COG0745	RESPONSE REGULATOR receiver
AM2010_RS08160	COG1960	acyl-CoA dehydrogenase activity
AM2010_RS08165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AM2010_RS08170	COG1024	Enoyl-CoA hydratase
AM2010_RS08175	COG0183	Belongs to the thiolase family
AM2010_RS08190	COG4993	Dehydrogenase
AM2010_RS08200	COG0530	calcium, potassium:sodium antiporter activity
AM2010_RS08215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AM2010_RS08250	COG1595	DNA-templated transcription, initiation
AM2010_RS08265	COG1595	DNA-templated transcription, initiation
AM2010_RS08270	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM2010_RS08280	COG3706	GGDEF domain
AM2010_RS08290	COG4771	TonB-dependent receptor
AM2010_RS08295	COG2814	Major facilitator Superfamily
AM2010_RS08305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AM2010_RS08310	COG1024	Enoyl-CoA hydratase
AM2010_RS08315	COG1028	Short-chain dehydrogenase reductase Sdr
AM2010_RS08320	COG4771	TonB-dependent receptor
AM2010_RS08325	COG2271	Major facilitator Superfamily
AM2010_RS08360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AM2010_RS08365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AM2010_RS08370	COG1960	acyl-CoA dehydrogenase activity
AM2010_RS08385	COG0022	dehydrogenase e1 component
AM2010_RS08385	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM2010_RS08390	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AM2010_RS08395	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM2010_RS08415	COG0587	DNA-directed DNA polymerase activity
AM2010_RS08455	COG2274	protein secretion by the type I secretion system
AM2010_RS08465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AM2010_RS08475	COG0640	Transcriptional regulator
AM2010_RS08485	COG1024	Enoyl-CoA hydratase
AM2010_RS08490	COG1960	acyl-CoA dehydrogenase activity
AM2010_RS08540	COG0811	peptide transport
AM2010_RS08555	COG1733	regulation of RNA biosynthetic process
AM2010_RS08570	COG4771	TonB-dependent receptor
AM2010_RS08645	COG1294	oxidase, subunit
AM2010_RS08665	COG0408	coproporphyrinogen oxidase activity
AM2010_RS08675	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AM2010_RS08685	COG0471	metal ion transport
AM2010_RS08690	COG0626	cystathionine gamma-synthase activity
AM2010_RS08700	COG0484	heat shock protein binding
AM2010_RS08705	COG2885	chlorophyll binding
AM2010_RS08710	COG0823	Involved in the tonB-independent uptake of proteins
AM2010_RS08730	COG0824	Thioesterase
AM2010_RS08740	COG0140	phosphoribosyl-ATP diphosphatase activity
AM2010_RS08750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM2010_RS08755	COG1028	Short-chain dehydrogenase reductase Sdr
AM2010_RS08825	COG5265	(ABC) transporter
AM2010_RS08830	COG0659	secondary active sulfate transmembrane transporter activity
AM2010_RS08845	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AM2010_RS08850	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AM2010_RS08870	COG0629	single-stranded DNA binding
AM2010_RS08875	COG1959	2 iron, 2 sulfur cluster binding
AM2010_RS08885	COG0105	UTP biosynthetic process
AM2010_RS08900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AM2010_RS08915	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AM2010_RS08920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AM2010_RS08930	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AM2010_RS08945	COG3724	N-succinylarginine dihydrolase activity
AM2010_RS08955	COG1970	mechanosensitive ion channel activity
AM2010_RS08975	COG0494	nUDIX hydrolase
AM2010_RS08990	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AM2010_RS09000	COG4181	ATPase activity
AM2010_RS09015	COG3152	Membrane
AM2010_RS09030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AM2010_RS09060	COG2308	Evidence 4 Homologs of previously reported genes of
AM2010_RS09065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM2010_RS09065	COG2226	methyltransferase
AM2010_RS09065	COG0596	Alpha beta hydrolase
AM2010_RS09075	COG0556	nucleotide-excision repair
AM2010_RS09085	COG3093	addiction module antidote protein HigA
AM2010_RS09105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM2010_RS09120	COG0181	hydroxymethylbilane synthase activity
AM2010_RS09125	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AM2010_RS09130	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AM2010_RS09145	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AM2010_RS09145	COG3743	rRNA binding
AM2010_RS09155	COG1960	acyl-CoA dehydrogenase activity
AM2010_RS09175	COG4771	TonB-dependent receptor
AM2010_RS09195	COG1960	acyl-CoA dehydrogenase activity
AM2010_RS09210	COG0318	PFAM AMP-dependent synthetase and ligase
AM2010_RS09220	COG1024	Enoyl-CoA hydratase
AM2010_RS09220	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM2010_RS09230	COG0251	oxidation-reduction process
AM2010_RS09235	COG0583	DNA-binding transcription factor activity
AM2010_RS09250	COG0583	DNA-binding transcription factor activity
AM2010_RS09255	COG1946	Acyl-CoA thioesterase
AM2010_RS09260	COG1028	Short-chain dehydrogenase reductase Sdr
AM2010_RS09280	COG0666	response to abiotic stimulus
AM2010_RS09285	COG1999	signal sequence binding
AM2010_RS09290	COG2983	Belongs to the UPF0260 family
AM2010_RS09305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM2010_RS09305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM2010_RS09325	COG1448	Aminotransferase
AM2010_RS09345	COG2375	cellular response to nickel ion
AM2010_RS09345	COG1132	(ABC) transporter
AM2010_RS09360	COG3191	aminopeptidase activity
AM2010_RS09365	COG4771	TonB-dependent receptor
AM2010_RS09370	COG3104	oligopeptide transport
AM2010_RS09375	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AM2010_RS09410	COG1012	belongs to the aldehyde dehydrogenase family
AM2010_RS09415	COG0686	Belongs to the AlaDH PNT family
AM2010_RS09430	COG1960	acyl-CoA dehydrogenase activity
AM2010_RS09445	COG1228	amidohydrolase
AM2010_RS09495	COG0798	PFAM Bile acid sodium symporter
AM2010_RS09515	COG4206	TonB-dependent receptor
AM2010_RS09525	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM2010_RS09535	COG2847	Copper chaperone PCu(A)C
AM2010_RS09540	COG1999	signal sequence binding
AM2010_RS09585	COG4786	Flagellar basal body rod
AM2010_RS09590	COG4786	Flagellar basal body rod
AM2010_RS09600	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AM2010_RS09605	COG1706	bacterial-type flagellum-dependent cell motility
AM2010_RS09615	COG1558	bacterial-type flagellum-dependent cell motility
AM2010_RS09620	COG1677	Flagellar hook-basal body complex protein FliE
AM2010_RS09640	COG1157	protein secretion by the type III secretion system
AM2010_RS09660	COG1749	Flagellar hook protein flgE
AM2010_RS09670	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AM2010_RS09680	COG1338	Plays a role in the flagellum-specific transport system
AM2010_RS09705	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AM2010_RS09715	COG1684	flagellar biosynthetic protein fliR
AM2010_RS09720	COG1987	bacterial-type flagellum assembly
AM2010_RS09725	COG1228	amidohydrolase
AM2010_RS09745	COG2072	flavoprotein involved in K transport
AM2010_RS09750	COG1546	Belongs to the CinA family
AM2010_RS09750	COG1058	Belongs to the CinA family
AM2010_RS09770	COG0081	regulation of translation
AM2010_RS09775	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AM2010_RS09790	COG1115	amino acid carrier protein
AM2010_RS09805	COG1028	Short-chain dehydrogenase reductase Sdr
AM2010_RS09845	COG0330	HflC and HflK could
AM2010_RS09855	COG0745	RESPONSE REGULATOR receiver
AM2010_RS09870	COG1012	belongs to the aldehyde dehydrogenase family
AM2010_RS09875	COG2323	membrane
AM2010_RS09885	COG2070	2-Nitropropane dioxygenase
AM2010_RS09890	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AM2010_RS09900	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AM2010_RS09915	COG0527	aspartate kinase activity
AM2010_RS09920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AM2010_RS09925	COG0584	glycerophosphoryl diester phosphodiesterase
AM2010_RS09930	COG1393	Belongs to the ArsC family
AM2010_RS09945	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AM2010_RS09950	COG0217	transcriptional regulatory protein
AM2010_RS09960	COG0393	Putative heavy-metal-binding
AM2010_RS09965	COG1028	Short-chain dehydrogenase reductase Sdr
AM2010_RS09970	COG3750	Belongs to the UPF0335 family
AM2010_RS09980	COG0469	pyruvate kinase activity
AM2010_RS09990	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AM2010_RS09990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AM2010_RS10000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AM2010_RS10005	COG0085	RNA polymerase activity
AM2010_RS10015	COG3655	Transcriptional regulator
AM2010_RS10025	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AM2010_RS10030	COG0222	ribosome binding
AM2010_RS10040	COG0534	Mate efflux family protein
AM2010_RS10045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AM2010_RS10050	COG0459	protein refolding
AM2010_RS10075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AM2010_RS10075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AM2010_RS10080	COG3920	Histidine kinase
AM2010_RS10090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM2010_RS10110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AM2010_RS10115	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AM2010_RS10120	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AM2010_RS10130	COG2890	protein-(glutamine-N5) methyltransferase activity
AM2010_RS10135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AM2010_RS10140	COG0124	histidyl-tRNA synthetase
AM2010_RS10145	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AM2010_RS10150	COG0668	transmembrane transport
AM2010_RS10155	COG0312	modulator of DNA gyrase
AM2010_RS10165	COG1137	ATPase activity
AM2010_RS10170	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AM2010_RS10180	COG0730	response to heat
AM2010_RS10185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AM2010_RS10205	COG0280	phosphate acetyltransferase
AM2010_RS10205	COG0281	malic enzyme
AM2010_RS10210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AM2010_RS10230	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM2010_RS10235	COG2096	Adenosyltransferase
AM2010_RS10245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AM2010_RS10265	COG3483	tryptophan 2,3-dioxygenase activity
AM2010_RS10275	COG4166	transmembrane transport
AM2010_RS10330	COG0156	8-amino-7-oxononanoate synthase activity
AM2010_RS10340	COG1764	response to oxidative stress
AM2010_RS10360	COG4695	Portal protein
AM2010_RS10435	COG2885	chlorophyll binding
AM2010_RS10435	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AM2010_RS10440	COG2032	superoxide dismutase activity
AM2010_RS10450	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AM2010_RS10465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AM2010_RS10470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AM2010_RS10475	COG1278	Cold shock
AM2010_RS10480	COG1253	flavin adenine dinucleotide binding
AM2010_RS10490	COG1473	amidohydrolase
AM2010_RS10510	COG0004	ammonium transporteR
AM2010_RS10515	COG0347	Belongs to the P(II) protein family
AM2010_RS10530	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AM2010_RS10535	COG4221	oxidoreductase activity
AM2010_RS10540	COG0072	phenylalanine-tRNA ligase activity
AM2010_RS10545	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AM2010_RS10555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AM2010_RS10560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AM2010_RS10570	COG0483	inositol monophosphate 1-phosphatase activity
AM2010_RS10575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AM2010_RS10580	COG1494	fructose-1,6-bisphosphatase
AM2010_RS10620	COG1201	RNA secondary structure unwinding
AM2010_RS10640	COG1192	Involved in chromosome partitioning
AM2010_RS10645	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AM2010_RS10660	COG5295	Hep Hag repeat protein
AM2010_RS10685	COG0175	sulfate reduction
AM2010_RS10695	COG1218	3'(2'),5'-bisphosphate nucleotidase
AM2010_RS10700	COG2885	chlorophyll binding
AM2010_RS10710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AM2010_RS10735	COG0308	aminopeptidase N
AM2010_RS10760	COG3428	Bacterial PH domain
AM2010_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
AM2010_RS10780	COG1609	Transcriptional regulator
AM2010_RS10790	COG1472	Belongs to the glycosyl hydrolase 3 family
AM2010_RS10810	COG0588	phosphoglycerate mutase activity
AM2010_RS10815	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AM2010_RS10820	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AM2010_RS10835	COG0196	riboflavin kinase activity
AM2010_RS10845	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AM2010_RS10850	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AM2010_RS10860	COG1253	flavin adenine dinucleotide binding
AM2010_RS10865	COG2885	chlorophyll binding
AM2010_RS10870	COG1218	3'(2'),5'-bisphosphate nucleotidase
AM2010_RS10875	COG0045	succinate-CoA ligase (ADP-forming) activity
AM2010_RS10885	COG2086	electron transfer activity
AM2010_RS10900	COG2733	membrane
AM2010_RS10930	COG0482	sulfurtransferase activity
AM2010_RS10955	COG0259	pyridoxamine-phosphate oxidase activity
AM2010_RS10960	COG0484	heat shock protein binding
AM2010_RS10965	COG1295	ribonuclease BN
AM2010_RS10970	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AM2010_RS10990	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AM2010_RS11005	COG0673	inositol 2-dehydrogenase activity
AM2010_RS11025	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AM2010_RS11050	COG0489	protein tyrosine kinase activity
AM2010_RS11050	COG3206	protein involved in exopolysaccharide biosynthesis
AM2010_RS11060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM2010_RS11070	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AM2010_RS11080	COG0793	Belongs to the peptidase S41A family
AM2010_RS11090	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AM2010_RS11095	COG0799	negative regulation of ribosome biogenesis
AM2010_RS11100	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AM2010_RS11105	COG0739	heme binding
AM2010_RS11115	COG0318	PFAM AMP-dependent synthetase and ligase
AM2010_RS11125	COG0438	transferase activity, transferring glycosyl groups
AM2010_RS11150	COG1793	dna ligase
AM2010_RS11150	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AM2010_RS11165	COG1872	DUF167
AM2010_RS11180	COG0519	Catalyzes the synthesis of GMP from XMP
AM2010_RS11185	COG0113	porphobilinogen synthase activity
AM2010_RS11190	COG0739	heme binding
AM2010_RS11200	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AM2010_RS11205	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AM2010_RS11210	COG1329	Transcriptional regulator
AM2010_RS11225	COG0009	L-threonylcarbamoyladenylate synthase
AM2010_RS11230	COG1960	acyl-CoA dehydrogenase activity
AM2010_RS11245	COG1956	GAF domain-containing protein
AM2010_RS11265	COG0357	Ribosomal RNA small subunit methyltransferase G
AM2010_RS11270	COG0445	tRNA wobble uridine modification
AM2010_RS11275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AM2010_RS11290	COG0069	glutamate synthase activity
AM2010_RS11305	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AM2010_RS11310	COG1981	membrane
AM2010_RS11315	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AM2010_RS11320	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AM2010_RS11325	COG0424	maF-like protein
AM2010_RS11330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AM2010_RS11335	COG0237	dephospho-CoA kinase activity
AM2010_RS11340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM2010_RS11345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AM2010_RS11395	COG0405	Gamma-glutamyltransferase
AM2010_RS11400	COG0167	dihydroorotate dehydrogenase activity
AM2010_RS11410	COG1959	2 iron, 2 sulfur cluster binding
AM2010_RS11415	COG0719	Fe-S assembly protein
AM2010_RS11425	COG0396	ATPase activity
AM2010_RS11435	COG0719	Fe-S assembly protein
AM2010_RS11445	COG2151	metal-sulfur cluster biosynthetic enzyme
AM2010_RS11450	COG0316	Belongs to the HesB IscA family
AM2010_RS11470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM2010_RS11475	COG0151	Belongs to the GarS family
AM2010_RS11480	COG1570	exodeoxyribonuclease VII activity
AM2010_RS11500	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AM2010_RS11505	COG0590	tRNA wobble adenosine to inosine editing
AM2010_RS11520	COG3279	Response regulator of the LytR AlgR family
AM2010_RS11525	COG3275	phosphorelay sensor kinase activity
AM2010_RS11560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AM2010_RS11580	COG2188	Transcriptional regulator
AM2010_RS11585	COG3104	oligopeptide transport
AM2010_RS11590	COG1228	amidohydrolase
AM2010_RS11600	COG0545	Peptidyl-prolyl cis-trans isomerase
AM2010_RS11615	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AM2010_RS11625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AM2010_RS11630	COG0138	bifunctional purine biosynthesis protein purh
AM2010_RS11660	COG1473	amidohydrolase
AM2010_RS11665	COG4206	TonB-dependent receptor
AM2010_RS11670	COG3268	Saccharopine dehydrogenase
AM2010_RS11675	COG0717	Belongs to the dCTP deaminase family
AM2010_RS11685	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AM2010_RS11685	COG0506	proline dehydrogenase activity
AM2010_RS11685	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AM2010_RS11695	COG2030	dehydratase
AM2010_RS11715	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AM2010_RS11745	COG0495	leucyl-tRNA aminoacylation
AM2010_RS11760	COG1028	Short-chain dehydrogenase reductase Sdr
AM2010_RS11780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AM2010_RS11805	COG0739	heme binding
AM2010_RS11810	COG2833	Protein of unknown function (DUF455)
AM2010_RS11815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AM2010_RS11820	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AM2010_RS11840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AM2010_RS11855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM2010_RS11860	COG2902	Dehydrogenase
AM2010_RS11870	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AM2010_RS11875	COG4152	abc transporter atp-binding protein
AM2010_RS11895	COG2022	thiamine diphosphate biosynthetic process
AM2010_RS11905	COG1612	heme a metabolic process
AM2010_RS11910	COG1324	tolerance protein
AM2010_RS11920	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AM2010_RS11925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AM2010_RS11940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM2010_RS11940	COG4651	solute:proton antiporter activity
AM2010_RS11970	COG2972	Histidine kinase
AM2010_RS11995	COG0823	Involved in the tonB-independent uptake of proteins
AM2010_RS11995	COG1506	peptidase
AM2010_RS12110	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AM2010_RS12150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM2010_RS12175	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AM2010_RS12185	COG0402	S-adenosylhomocysteine deaminase activity
AM2010_RS12195	COG1960	acyl-CoA dehydrogenase activity
AM2010_RS12200	COG0251	oxidation-reduction process
AM2010_RS12210	COG1960	acyl-CoA dehydrogenase activity
AM2010_RS12215	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AM2010_RS12235	COG0436	Aminotransferase
AM2010_RS12275	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AM2010_RS12280	COG2095	MarC family integral membrane protein
AM2010_RS12290	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AM2010_RS12300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AM2010_RS12310	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
AM2010_RS12315	COG0183	Belongs to the thiolase family
AM2010_RS12335	COG0514	ATP-dependent DNA helicase (RecQ)
AM2010_RS12375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AM2010_RS12385	COG0564	pseudouridine synthase activity
AM2010_RS12395	COG0433	COG0433 Predicted ATPase
AM2010_RS12400	COG2205	protein histidine kinase activity
AM2010_RS12440	COG3706	GGDEF domain
AM2010_RS12445	COG0686	Belongs to the AlaDH PNT family
AM2010_RS12450	COG3746	phosphate-selective porin O and P
AM2010_RS12455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AM2010_RS12460	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AM2010_RS12465	COG1285	pathogenesis
AM2010_RS12510	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AM2010_RS12515	COG0318	PFAM AMP-dependent synthetase and ligase
AM2010_RS12520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AM2010_RS12530	COG1174	glycine betaine transport
AM2010_RS12535	COG1125	glycine betaine transport
AM2010_RS12540	COG5001	Diguanylate cyclase
AM2010_RS12545	COG1960	acyl-CoA dehydrogenase activity
AM2010_RS12550	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AM2010_RS12555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AM2010_RS12585	COG1760	l-serine dehydratase
AM2010_RS12590	COG0318	PFAM AMP-dependent synthetase and ligase
AM2010_RS12600	COG0519	Catalyzes the synthesis of GMP from XMP
AM2010_RS12600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AM2010_RS12610	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AM2010_RS12635	COG0312	modulator of DNA gyrase
AM2010_RS12645	COG1131	(ABC) transporter
AM2010_RS12665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AM2010_RS12665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AM2010_RS12720	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AM2010_RS12725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AM2010_RS12735	COG1609	Transcriptional regulator
AM2010_RS12745	COG1028	Short-chain dehydrogenase reductase Sdr
AM2010_RS12780	COG3507	Belongs to the glycosyl hydrolase 43 family
AM2010_RS12785	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AM2010_RS12800	COG2721	sulfolactate sulfo-lyase activity
AM2010_RS12805	COG1904	glucuronate isomerase
AM2010_RS12810	COG0246	Mannitol dehydrogenase
AM2010_RS12820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM2010_RS12825	COG2226	methyltransferase
AM2010_RS12835	COG1410	methionine synthase
AM2010_RS12835	COG0646	methionine synthase
AM2010_RS12845	COG1410	methionine synthase
AM2010_RS12845	COG0646	methionine synthase
AM2010_RS12850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AM2010_RS12855	COG0509	glycine decarboxylation via glycine cleavage system
AM2010_RS12860	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AM2010_RS12865	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AM2010_RS12890	COG1024	Enoyl-CoA hydratase
AM2010_RS12895	COG1024	Enoyl-CoA hydratase
AM2010_RS12930	COG1028	Short-chain dehydrogenase reductase Sdr
AM2010_RS12940	COG2204	response regulator
AM2010_RS12945	COG4191	Histidine kinase
AM2010_RS12950	COG1301	dicarboxylic acid transport
AM2010_RS12955	COG2755	lipolytic protein G-D-S-L family
AM2010_RS12955	COG0657	acetylesterase activity
AM2010_RS12960	COG4206	TonB-dependent receptor
AM2010_RS12970	COG2070	2-Nitropropane dioxygenase
AM2010_RS13000	COG4771	TonB-dependent receptor
AM2010_RS13005	COG4221	oxidoreductase activity
AM2010_RS13015	COG0318	PFAM AMP-dependent synthetase and ligase
AM2010_RS13025	COG1021	2,3-dihydroxybenzoate-AMP ligase
AM2010_RS13030	COG0183	Belongs to the thiolase family
AM2010_RS13040	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AM2010_RS13050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM2010_RS13050	COG2813	Specifically methylates the guanine in position
AM2010_RS13055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM2010_RS13060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AM2010_RS13065	COG0287	Prephenate dehydrogenase
AM2010_RS13085	COG2884	Cell division ATP-binding protein ftsE
AM2010_RS13130	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AM2010_RS13155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AM2010_RS13160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AM2010_RS13170	COG0330	HflC and HflK could
AM2010_RS13180	COG0489	protein tyrosine kinase activity
AM2010_RS13190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AM2010_RS13210	COG2226	methyltransferase
AM2010_RS13215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AM2010_RS13225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM2010_RS13225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AM2010_RS13255	COG3186	Phenylalanine-4-hydroxylase
AM2010_RS13270	COG1968	undecaprenyl-diphosphatase activity
AM2010_RS13280	COG1132	(ABC) transporter
AM2010_RS13295	COG0183	Belongs to the thiolase family
AM2010_RS13330	COG1758	RNA polymerase activity
AM2010_RS13340	COG0305	Participates in initiation and elongation during chromosome replication
AM2010_RS13345	COG5328	Belongs to the UPF0262 family
AM2010_RS13355	COG0295	cytidine deaminase activity
AM2010_RS13360	COG2866	Carboxypeptidase
AM2010_RS13375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AM2010_RS13405	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AM2010_RS13410	COG0594	ribonuclease P activity
AM2010_RS13415	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AM2010_RS13420	COG0706	membrane insertase activity
AM2010_RS13425	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AM2010_RS13430	COG0454	-acetyltransferase
AM2010_RS13445	COG0668	transmembrane transport
AM2010_RS13455	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AM2010_RS13465	COG2989	Protein conserved in bacteria
AM2010_RS13475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AM2010_RS13490	COG2255	four-way junction helicase activity
AM2010_RS13500	COG0632	four-way junction helicase activity
AM2010_RS13505	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AM2010_RS13510	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AM2010_RS13520	COG0450	alkyl hydroperoxide reductase
AM2010_RS13525	COG3634	alkyl hydroperoxide reductase activity
AM2010_RS13535	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AM2010_RS13540	COG4395	Tim44
AM2010_RS13545	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AM2010_RS13550	COG0728	peptidoglycan biosynthetic process
AM2010_RS13555	COG0180	Tryptophanyl-tRNA synthetase
AM2010_RS13565	COG0756	dUTP diphosphatase activity
AM2010_RS13570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AM2010_RS13585	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AM2010_RS13590	COG2226	methyltransferase
AM2010_RS13595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AM2010_RS13600	COG0268	Binds directly to 16S ribosomal RNA
AM2010_RS13695	COG3712	iron ion homeostasis
AM2010_RS13705	COG4977	sequence-specific DNA binding
AM2010_RS13705	COG1917	Cupin 2, conserved barrel domain protein
AM2010_RS13805	COG1766	The M ring may be actively involved in energy transduction
AM2010_RS13810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AM2010_RS13830	COG0385	Bile acid