locus-tag	class	description
A6F65_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6F65_RS00010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6F65_RS00030	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6F65_RS00060	COG1301	dicarboxylic acid transport
A6F65_RS00065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6F65_RS00070	COG0625	glutathione transferase activity
A6F65_RS00085	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6F65_RS00090	COG0706	membrane insertase activity
A6F65_RS00095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A6F65_RS00100	COG0594	ribonuclease P activity
A6F65_RS00105	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6F65_RS00120	COG0606	chelatase, subunit chli
A6F65_RS00125	COG0531	amino acid
A6F65_RS00175	COG0154	amidase activity
A6F65_RS00200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6F65_RS00205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6F65_RS00210	COG1960	acyl-CoA dehydrogenase activity
A6F65_RS00220	COG2301	Belongs to the HpcH HpaI aldolase family
A6F65_RS00235	COG4771	TonB-dependent receptor
A6F65_RS00245	COG4771	TonB-dependent receptor
A6F65_RS00260	COG0247	lactate metabolic process
A6F65_RS00260	COG0277	FAD linked oxidase domain protein
A6F65_RS00275	COG1012	belongs to the aldehyde dehydrogenase family
A6F65_RS00290	COG1335	isochorismatase
A6F65_RS00305	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6F65_RS00315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6F65_RS00330	COG1522	sequence-specific DNA binding
A6F65_RS00340	COG2271	Major facilitator Superfamily
A6F65_RS00350	COG2130	NADP-dependent
A6F65_RS00375	COG2226	methyltransferase
A6F65_RS00400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6F65_RS00415	COG2866	Carboxypeptidase
A6F65_RS00425	COG0295	cytidine deaminase activity
A6F65_RS00435	COG5328	Belongs to the UPF0262 family
A6F65_RS00440	COG0305	Participates in initiation and elongation during chromosome replication
A6F65_RS00450	COG1758	RNA polymerase activity
A6F65_RS00470	COG1482	cell wall glycoprotein biosynthetic process
A6F65_RS00480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6F65_RS00490	COG3383	formate dehydrogenase (NAD+) activity
A6F65_RS00495	COG0746	molybdenum cofactor guanylyltransferase activity
A6F65_RS00510	COG0583	DNA-binding transcription factor activity
A6F65_RS00520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6F65_RS00520	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6F65_RS00530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6F65_RS00550	COG1012	belongs to the aldehyde dehydrogenase family
A6F65_RS00555	COG0583	DNA-binding transcription factor activity
A6F65_RS00560	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A6F65_RS00565	COG0457	Tetratricopeptide repeat
A6F65_RS00570	COG4771	TonB-dependent receptor
A6F65_RS00575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6F65_RS00580	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A6F65_RS00585	COG0583	DNA-binding transcription factor activity
A6F65_RS00595	COG4638	Rieske (2fe-2S)
A6F65_RS00605	COG0006	proline dipeptidase activity
A6F65_RS00615	COG5598	trimethylamine methyltransferase
A6F65_RS00650	COG5012	cobalamin binding
A6F65_RS00670	COG2175	clavaminate synthase activity
A6F65_RS00680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6F65_RS00680	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6F65_RS00705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6F65_RS00745	COG0582	viral genome integration into host DNA
A6F65_RS00765	COG0330	HflC and HflK could
A6F65_RS00775	COG3118	belongs to the thioredoxin family
A6F65_RS00780	COG3118	belongs to the thioredoxin family
A6F65_RS00810	COG2070	2-Nitropropane dioxygenase
A6F65_RS00820	COG0527	aspartate kinase activity
A6F65_RS00825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6F65_RS00830	COG0584	glycerophosphoryl diester phosphodiesterase
A6F65_RS00835	COG1393	Belongs to the ArsC family
A6F65_RS00850	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6F65_RS00860	COG0217	transcriptional regulatory protein
A6F65_RS00870	COG0393	Putative heavy-metal-binding
A6F65_RS00875	COG3750	Belongs to the UPF0335 family
A6F65_RS00885	COG0469	pyruvate kinase activity
A6F65_RS00890	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A6F65_RS00900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F65_RS00900	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A6F65_RS00910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6F65_RS00915	COG0085	RNA polymerase activity
A6F65_RS00925	COG3655	Transcriptional regulator
A6F65_RS00940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6F65_RS00945	COG0222	ribosome binding
A6F65_RS00960	COG0596	Alpha beta hydrolase
A6F65_RS00965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6F65_RS00965	COG0475	glutathione-regulated potassium exporter activity
A6F65_RS00970	COG0534	Mate efflux family protein
A6F65_RS00975	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6F65_RS00980	COG0459	protein refolding
A6F65_RS01000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6F65_RS01000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6F65_RS01005	COG3920	Histidine kinase
A6F65_RS01015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6F65_RS01035	COG2814	Major facilitator Superfamily
A6F65_RS01065	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6F65_RS01070	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6F65_RS01080	COG2890	protein-(glutamine-N5) methyltransferase activity
A6F65_RS01085	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6F65_RS01090	COG0124	histidyl-tRNA synthetase
A6F65_RS01095	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6F65_RS01110	COG0668	transmembrane transport
A6F65_RS01120	COG1137	ATPase activity
A6F65_RS01125	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A6F65_RS01135	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6F65_RS01140	COG1988	membrane-bound metal-dependent
A6F65_RS01155	COG0281	malic enzyme
A6F65_RS01155	COG0280	phosphate acetyltransferase
A6F65_RS01160	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6F65_RS01185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F65_RS01205	COG3483	tryptophan 2,3-dioxygenase activity
A6F65_RS01215	COG0747	negative chemotaxis
A6F65_RS01270	COG0156	8-amino-7-oxononanoate synthase activity
A6F65_RS01275	COG1764	response to oxidative stress
A6F65_RS01295	COG2827	Endonuclease containing a URI domain
A6F65_RS01300	COG4695	Portal protein
A6F65_RS01375	COG2032	superoxide dismutase activity
A6F65_RS01380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6F65_RS01390	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6F65_RS01395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6F65_RS01400	COG1278	Cold shock
A6F65_RS01405	COG1253	flavin adenine dinucleotide binding
A6F65_RS01420	COG2885	chlorophyll binding
A6F65_RS01420	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6F65_RS01425	COG0004	ammonium transporteR
A6F65_RS01430	COG0347	Belongs to the P(II) protein family
A6F65_RS01445	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A6F65_RS01450	COG4221	oxidoreductase activity
A6F65_RS01455	COG0072	phenylalanine-tRNA ligase activity
A6F65_RS01460	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6F65_RS01465	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6F65_RS01470	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6F65_RS01490	COG1494	fructose-1,6-bisphosphatase
A6F65_RS01530	COG1201	RNA secondary structure unwinding
A6F65_RS01550	COG1192	Involved in chromosome partitioning
A6F65_RS01555	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6F65_RS01560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6F65_RS01565	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6F65_RS01570	COG0509	glycine decarboxylation via glycine cleavage system
A6F65_RS01575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6F65_RS01580	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6F65_RS01595	COG3800	Transcriptional regulator
A6F65_RS01595	COG1396	sequence-specific DNA binding
A6F65_RS01605	COG2885	chlorophyll binding
A6F65_RS01615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6F65_RS01635	COG1496	oxidoreductase activity
A6F65_RS01640	COG0308	aminopeptidase N
A6F65_RS01665	COG3428	Bacterial PH domain
A6F65_RS01680	COG0588	phosphoglycerate mutase activity
A6F65_RS01690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6F65_RS01705	COG0196	riboflavin kinase activity
A6F65_RS01710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6F65_RS01715	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6F65_RS01725	COG1253	flavin adenine dinucleotide binding
A6F65_RS01730	COG2885	chlorophyll binding
A6F65_RS01735	COG0483	inositol monophosphate 1-phosphatase activity
A6F65_RS01740	COG0045	succinate-CoA ligase (ADP-forming) activity
A6F65_RS01755	COG2086	electron transfer activity
A6F65_RS01775	COG2733	membrane
A6F65_RS01785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F65_RS01805	COG0482	sulfurtransferase activity
A6F65_RS01835	COG0259	pyridoxamine-phosphate oxidase activity
A6F65_RS01840	COG0484	heat shock protein binding
A6F65_RS01845	COG1295	ribonuclease BN
A6F65_RS01850	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6F65_RS01870	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
A6F65_RS01880	COG0793	Belongs to the peptidase S41A family
A6F65_RS01885	COG4942	peptidase
A6F65_RS01890	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6F65_RS01895	COG0799	negative regulation of ribosome biogenesis
A6F65_RS01900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6F65_RS01905	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6F65_RS01910	COG0739	heme binding
A6F65_RS01945	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A6F65_RS01945	COG1793	dna ligase
A6F65_RS01955	COG1793	dna ligase
A6F65_RS01965	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6F65_RS01980	COG0113	porphobilinogen synthase activity
A6F65_RS01985	COG0739	heme binding
A6F65_RS01995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6F65_RS02000	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A6F65_RS02010	COG1329	Transcriptional regulator
A6F65_RS02040	COG1956	GAF domain-containing protein
A6F65_RS02075	COG0357	Ribosomal RNA small subunit methyltransferase G
A6F65_RS02080	COG0445	tRNA wobble uridine modification
A6F65_RS02085	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6F65_RS02100	COG0069	glutamate synthase activity
A6F65_RS02115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6F65_RS02120	COG1981	membrane
A6F65_RS02125	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6F65_RS02130	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A6F65_RS02135	COG0424	maF-like protein
A6F65_RS02140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6F65_RS02145	COG0237	dephospho-CoA kinase activity
A6F65_RS02150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6F65_RS02155	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6F65_RS02160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6F65_RS02185	COG0316	Belongs to the HesB IscA family
A6F65_RS02190	COG0517	IMP dehydrogenase activity
A6F65_RS02205	COG1506	peptidase
A6F65_RS02205	COG0823	Involved in the tonB-independent uptake of proteins
A6F65_RS02220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6F65_RS02225	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A6F65_RS02225	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A6F65_RS02230	COG2972	Histidine kinase
A6F65_RS02255	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6F65_RS02260	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6F65_RS02275	COG1612	heme a metabolic process
A6F65_RS02285	COG2022	thiamine diphosphate biosynthetic process
A6F65_RS02300	COG1022	Amp-dependent synthetase and ligase
A6F65_RS02305	COG0405	Gamma-glutamyltransferase
A6F65_RS02310	COG0167	dihydroorotate dehydrogenase activity
A6F65_RS02315	COG1959	2 iron, 2 sulfur cluster binding
A6F65_RS02320	COG0719	Fe-S assembly protein
A6F65_RS02330	COG0396	ATPase activity
A6F65_RS02335	COG0719	Fe-S assembly protein
A6F65_RS02340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6F65_RS02345	COG2151	metal-sulfur cluster biosynthetic enzyme
A6F65_RS02355	COG0316	Belongs to the HesB IscA family
A6F65_RS02370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F65_RS02375	COG0151	Belongs to the GarS family
A6F65_RS02380	COG1570	exodeoxyribonuclease VII activity
A6F65_RS02390	COG0739	heme binding
A6F65_RS02400	COG0457	Tetratricopeptide repeat
A6F65_RS02405	COG0457	Tetratricopeptide repeat
A6F65_RS02410	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6F65_RS02415	COG0590	tRNA wobble adenosine to inosine editing
A6F65_RS02435	COG3279	Response regulator of the LytR AlgR family
A6F65_RS02440	COG3275	phosphorelay sensor kinase activity
A6F65_RS02500	COG4650	regulator
A6F65_RS02510	COG1690	Belongs to the RtcB family
A6F65_RS02515	COG0430	RNA-3'-phosphate cyclase activity
A6F65_RS02540	COG1082	Xylose isomerase domain protein TIM barrel
A6F65_RS02555	COG2188	Transcriptional regulator
A6F65_RS02565	COG0804	urea catabolic process
A6F65_RS02595	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6F65_RS02605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F65_RS02615	COG0138	bifunctional purine biosynthesis protein purh
A6F65_RS02665	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6F65_RS02665	COG0493	'glutamate synthase
A6F65_RS02690	COG4152	abc transporter atp-binding protein
A6F65_RS02695	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6F65_RS02705	COG2902	Dehydrogenase
A6F65_RS02735	COG0495	leucyl-tRNA aminoacylation
A6F65_RS02775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6F65_RS02785	COG0739	heme binding
A6F65_RS02790	COG2833	Protein of unknown function (DUF455)
A6F65_RS02795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6F65_RS02800	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A6F65_RS02810	COG2957	Belongs to the agmatine deiminase family
A6F65_RS02825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6F65_RS02880	COG0110	maltose O-acetyltransferase activity
A6F65_RS02895	COG0438	transferase activity, transferring glycosyl groups
A6F65_RS02915	COG1216	Glycosyl transferase, family 2
A6F65_RS02920	COG0297	glycogen (starch) synthase activity
A6F65_RS02925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6F65_RS02930	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A6F65_RS02950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6F65_RS02955	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6F65_RS02965	COG0070	glutamate synthase
A6F65_RS02965	COG0069	glutamate synthase activity
A6F65_RS02965	COG0067	glutamate synthase
A6F65_RS02975	COG0438	transferase activity, transferring glycosyl groups
A6F65_RS02995	COG1132	(ABC) transporter
A6F65_RS03000	COG3590	peptidase
A6F65_RS03005	COG1968	undecaprenyl-diphosphatase activity
A6F65_RS03020	COG3186	Phenylalanine-4-hydroxylase
A6F65_RS03035	COG0514	ATP-dependent DNA helicase (RecQ)
A6F65_RS03050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6F65_RS03055	COG0688	phosphatidylethanolamine metabolic process
A6F65_RS03080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6F65_RS03090	COG0564	pseudouridine synthase activity
A6F65_RS03105	COG0433	COG0433 Predicted ATPase
A6F65_RS03120	COG2205	protein histidine kinase activity
A6F65_RS03150	COG0513	Belongs to the DEAD box helicase family
A6F65_RS03165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6F65_RS03180	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A6F65_RS03185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6F65_RS03200	COG1960	acyl-CoA dehydrogenase activity
A6F65_RS03205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6F65_RS03240	COG1760	l-serine dehydratase
A6F65_RS03245	COG0519	Catalyzes the synthesis of GMP from XMP
A6F65_RS03245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6F65_RS03265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6F65_RS03300	COG1131	(ABC) transporter
A6F65_RS03330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6F65_RS03330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6F65_RS03385	COG2852	Protein conserved in bacteria
A6F65_RS03425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6F65_RS03440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6F65_RS03450	COG2095	MarC family integral membrane protein
A6F65_RS03470	COG4771	TonB-dependent receptor
A6F65_RS03475	COG3268	Saccharopine dehydrogenase
A6F65_RS03480	COG0717	Belongs to the dCTP deaminase family
A6F65_RS03485	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A6F65_RS03485	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A6F65_RS03485	COG0506	proline dehydrogenase activity
A6F65_RS03500	COG2205	protein histidine kinase activity
A6F65_RS03515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6F65_RS03525	COG0346	lactoylglutathione lyase activity
A6F65_RS03530	COG1024	Enoyl-CoA hydratase
A6F65_RS03535	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6F65_RS03535	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6F65_RS03550	COG4770	biotin carboxylase activity
A6F65_RS03565	COG0577	efflux transmembrane transporter activity
A6F65_RS03565	COG1136	(ABC) transporter
A6F65_RS03585	COG0587	DNA-directed DNA polymerase activity
A6F65_RS03590	COG2202	Pas domain
A6F65_RS03590	COG3920	Histidine kinase
A6F65_RS03610	COG2124	cytochrome p450
A6F65_RS03635	COG1609	Transcriptional regulator
A6F65_RS03650	COG1621	beta-fructofuranosidase activity
A6F65_RS03655	COG1940	carbohydrate kinase activity
A6F65_RS03675	COG2884	Cell division ATP-binding protein ftsE
A6F65_RS03690	COG0204	Acyl-transferase
A6F65_RS03695	COG0287	Prephenate dehydrogenase
A6F65_RS03700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6F65_RS03705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F65_RS03710	COG2813	Specifically methylates the guanine in position
A6F65_RS03710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F65_RS03715	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6F65_RS03730	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A6F65_RS03750	COG2072	flavoprotein involved in K transport
A6F65_RS03755	COG1546	Belongs to the CinA family
A6F65_RS03755	COG1058	Belongs to the CinA family
A6F65_RS03765	COG0081	regulation of translation
A6F65_RS03770	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6F65_RS03795	COG1115	amino acid carrier protein
A6F65_RS03815	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6F65_RS03840	COG0318	PFAM AMP-dependent synthetase and ligase
A6F65_RS03905	COG0784	Response regulator, receiver
A6F65_RS03905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6F65_RS03905	COG2205	protein histidine kinase activity
A6F65_RS03905	COG2198	Histidine kinase
A6F65_RS03940	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6F65_RS03945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6F65_RS03945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F65_RS03955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F65_RS03960	COG0596	Alpha beta hydrolase
A6F65_RS03980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6F65_RS03985	COG2010	Cytochrome c
A6F65_RS03985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6F65_RS03990	COG0489	protein tyrosine kinase activity
A6F65_RS04015	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F65_RS04080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6F65_RS04105	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A6F65_RS04110	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6F65_RS04115	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6F65_RS04120	COG1216	Glycosyl transferase, family 2
A6F65_RS04145	COG1132	(ABC) transporter
A6F65_RS04160	COG0366	Alpha amylase catalytic
A6F65_RS04195	COG1448	Aminotransferase
A6F65_RS04210	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6F65_RS04210	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6F65_RS04230	COG2983	Belongs to the UPF0260 family
A6F65_RS04235	COG1999	signal sequence binding
A6F65_RS04260	COG0629	single-stranded DNA binding
A6F65_RS04285	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6F65_RS04305	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6F65_RS04315	COG0659	secondary active sulfate transmembrane transporter activity
A6F65_RS04325	COG5265	(ABC) transporter
A6F65_RS04395	COG0175	sulfate reduction
A6F65_RS04405	COG1609	Transcriptional regulator
A6F65_RS04415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6F65_RS04420	COG3001	Fructosamine kinase
A6F65_RS04425	COG1024	Enoyl-CoA hydratase
A6F65_RS04430	COG1960	acyl-CoA dehydrogenase activity
A6F65_RS04450	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6F65_RS04465	COG3119	arylsulfatase activity
A6F65_RS04470	COG1472	Belongs to the glycosyl hydrolase 3 family
A6F65_RS04475	COG1609	Transcriptional regulator
A6F65_RS04485	COG3119	arylsulfatase activity
A6F65_RS04490	COG3119	arylsulfatase activity
A6F65_RS04500	COG3119	arylsulfatase activity
A6F65_RS04515	COG3119	arylsulfatase activity
A6F65_RS04520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6F65_RS04540	COG0783	Belongs to the Dps family
A6F65_RS04565	COG4989	oxidoreductase activity
A6F65_RS04635	COG1131	(ABC) transporter
A6F65_RS04660	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6F65_RS04675	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6F65_RS04690	COG3040	lipid binding
A6F65_RS04695	COG1671	Belongs to the UPF0178 family
A6F65_RS04705	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6F65_RS04720	COG1278	Cold shock
A6F65_RS04730	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6F65_RS04750	COG1881	PFAM PEBP family protein
A6F65_RS04795	COG2171	N-acyltransferase activity
A6F65_RS04805	COG1404	Belongs to the peptidase S8 family
A6F65_RS04810	COG0194	GDP metabolic process
A6F65_RS04825	COG0131	Imidazoleglycerol-phosphate dehydratase
A6F65_RS04830	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6F65_RS04835	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6F65_RS04840	COG0107	imidazoleglycerol-phosphate synthase activity
A6F65_RS04845	COG0140	phosphoribosyl-ATP diphosphatase activity
A6F65_RS04870	COG0848	biopolymer transport protein
A6F65_RS04880	COG0823	Involved in the tonB-independent uptake of proteins
A6F65_RS04885	COG2885	chlorophyll binding
A6F65_RS04895	COG0484	heat shock protein binding
A6F65_RS04905	COG0626	cystathionine gamma-synthase activity
A6F65_RS04920	COG0471	metal ion transport
A6F65_RS04935	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6F65_RS04945	COG0408	coproporphyrinogen oxidase activity
A6F65_RS04965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6F65_RS04970	COG0569	domain protein
A6F65_RS05010	COG0477	Major facilitator Superfamily
A6F65_RS05030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6F65_RS05045	COG1609	Transcriptional regulator
A6F65_RS05055	COG1028	Short-chain dehydrogenase reductase Sdr
A6F65_RS05070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6F65_RS05075	COG1960	acyl-CoA dehydrogenase activity
A6F65_RS05100	COG1024	Enoyl-CoA hydratase
A6F65_RS05135	COG0346	lactoylglutathione lyase activity
A6F65_RS05150	COG0686	Belongs to the AlaDH PNT family
A6F65_RS05155	COG3755	Protein conserved in bacteria
A6F65_RS05165	COG0784	Response regulator, receiver
A6F65_RS05185	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6F65_RS05190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6F65_RS05195	COG0181	hydroxymethylbilane synthase activity
A6F65_RS05210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6F65_RS05225	COG0556	nucleotide-excision repair
A6F65_RS05240	COG2226	methyltransferase
A6F65_RS05240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F65_RS05240	COG0596	Alpha beta hydrolase
A6F65_RS05245	COG2308	Evidence 4 Homologs of previously reported genes of
A6F65_RS05265	COG4566	intracellular signal transduction
A6F65_RS05280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6F65_RS05285	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A6F65_RS05290	COG0784	Response regulator, receiver
A6F65_RS05300	COG0656	L-ascorbic acid biosynthetic process
A6F65_RS05305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6F65_RS05325	COG0252	asparaginase activity
A6F65_RS05345	COG0165	Argininosuccinate lyase
A6F65_RS05355	COG0019	diaminopimelate decarboxylase activity
A6F65_RS05360	COG1648	precorrin-2 dehydrogenase activity
A6F65_RS05360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6F65_RS05375	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6F65_RS05385	COG0628	permease
A6F65_RS05395	COG0736	holo-[acyl-carrier-protein] synthase activity
A6F65_RS05400	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6F65_RS05405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6F65_RS05410	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6F65_RS05415	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6F65_RS05420	COG0109	protoheme IX farnesyltransferase activity
A6F65_RS05425	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A6F65_RS05460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6F65_RS05480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6F65_RS05490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6F65_RS05495	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6F65_RS05510	COG2197	response regulator
A6F65_RS05515	COG4585	Histidine kinase
A6F65_RS05535	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6F65_RS05545	COG0424	maF-like protein
A6F65_RS05550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6F65_RS05560	COG2081	HI0933 family
A6F65_RS05565	COG0322	excinuclease ABC activity
A6F65_RS05595	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A6F65_RS05610	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6F65_RS05620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6F65_RS05625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6F65_RS05630	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6F65_RS05640	COG0596	Alpha beta hydrolase
A6F65_RS05645	COG0545	Peptidyl-prolyl cis-trans isomerase
A6F65_RS05650	COG1741	Belongs to the pirin family
A6F65_RS05670	COG5507	3-demethylubiquinone-9 3-methyltransferase
A6F65_RS05680	COG5001	Diguanylate cyclase
A6F65_RS05685	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6F65_RS05690	COG0101	tRNA pseudouridine synthase activity
A6F65_RS05695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6F65_RS05700	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6F65_RS05705	COG0242	peptide deformylase activity
A6F65_RS05720	COG1322	Protein conserved in bacteria
A6F65_RS05730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6F65_RS05740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6F65_RS05740	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6F65_RS05745	COG1660	Displays ATPase and GTPase activities
A6F65_RS05755	COG0642	Histidine kinase
A6F65_RS05760	COG0745	RESPONSE REGULATOR receiver
A6F65_RS05765	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6F65_RS05790	COG0492	ferredoxin-NADP+ reductase activity
A6F65_RS05820	COG2945	thiolester hydrolase activity
A6F65_RS05830	COG1104	cysteine desulfurase activity
A6F65_RS05850	COG0693	protein deglycase activity
A6F65_RS05855	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6F65_RS05860	COG5002	protein histidine kinase activity
A6F65_RS05860	COG0784	Response regulator, receiver
A6F65_RS05865	COG0617	tRNA 3'-terminal CCA addition
A6F65_RS05885	COG2133	pyrroloquinoline quinone binding
A6F65_RS05890	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6F65_RS05895	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6F65_RS05905	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A6F65_RS05910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6F65_RS05915	COG1028	Short-chain dehydrogenase reductase Sdr
A6F65_RS05955	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6F65_RS05980	COG0697	spore germination
A6F65_RS06005	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6F65_RS06015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6F65_RS06020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6F65_RS06025	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6F65_RS06030	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6F65_RS06055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6F65_RS06055	COG2169	Transcriptional regulator
A6F65_RS06065	COG1196	nuclear chromosome segregation
A6F65_RS06075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6F65_RS06075	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6F65_RS06085	COG1194	a g-specific adenine glycosylase
A6F65_RS06120	COG2239	Acts as a magnesium transporter
A6F65_RS06135	COG0583	DNA-binding transcription factor activity
A6F65_RS06140	COG1253	flavin adenine dinucleotide binding
A6F65_RS06145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6F65_RS06160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6F65_RS06180	COG4957	zinc ion binding
A6F65_RS06200	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6F65_RS06205	COG0612	Peptidase, M16
A6F65_RS06210	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A6F65_RS06215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6F65_RS06235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6F65_RS06240	COG0625	glutathione transferase activity
A6F65_RS06260	COG1054	Belongs to the UPF0176 family
A6F65_RS06270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6F65_RS06280	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A6F65_RS06295	COG1381	Involved in DNA repair and RecF pathway recombination
A6F65_RS06300	COG0473	3-isopropylmalate dehydrogenase activity
A6F65_RS06330	COG2967	ApaG domain
A6F65_RS06385	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6F65_RS06390	COG0049	tRNA binding
A6F65_RS06395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6F65_RS06400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6F65_RS06405	COG0051	transcription antitermination factor activity, RNA binding
A6F65_RS06410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6F65_RS06415	COG0088	Forms part of the polypeptide exit tunnel
A6F65_RS06420	COG0089	rRNA binding
A6F65_RS06425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6F65_RS06430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6F65_RS06435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6F65_RS06440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6F65_RS06445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6F65_RS06450	COG0255	Belongs to the universal ribosomal protein uL29 family
A6F65_RS06455	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6F65_RS06460	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6F65_RS06465	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6F65_RS06470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6F65_RS06475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6F65_RS06480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6F65_RS06485	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6F65_RS06490	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6F65_RS06495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6F65_RS06500	COG1841	ribosomal large subunit assembly
A6F65_RS06510	COG0200	Binds to the 23S rRNA
A6F65_RS06515	COG0201	protein transport
A6F65_RS06520	COG0563	adenylate kinase activity
A6F65_RS06535	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6F65_RS06540	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6F65_RS06545	COG0202	RNA polymerase activity
A6F65_RS06550	COG0203	ribosomal protein L17
A6F65_RS06555	COG1505	serine-type exopeptidase activity
A6F65_RS06570	COG2860	membrane
A6F65_RS06585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6F65_RS06595	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F65_RS06605	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6F65_RS06615	COG0039	L-malate dehydrogenase activity
A6F65_RS06620	COG3300	MHYT domain
A6F65_RS06620	COG5001	Diguanylate cyclase
A6F65_RS06635	COG4206	TonB-dependent receptor
A6F65_RS06650	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6F65_RS06675	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A6F65_RS06690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6F65_RS06715	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6F65_RS06720	COG0137	argininosuccinate synthase activity
A6F65_RS06730	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6F65_RS06735	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
A6F65_RS06745	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6F65_RS06760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6F65_RS06765	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6F65_RS06780	COG2268	Band 7 protein
A6F65_RS06790	COG0741	lytic transglycosylase activity
A6F65_RS06795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6F65_RS06805	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6F65_RS06830	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6F65_RS06835	COG4106	trans-aconitate 2-methyltransferase activity
A6F65_RS06840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6F65_RS06850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F65_RS06855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F65_RS06855	COG3153	acetyltransferase
A6F65_RS06860	COG0538	isocitrate dehydrogenase activity
A6F65_RS06885	COG1960	acyl-CoA dehydrogenase activity
A6F65_RS06890	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6F65_RS06890	COG1024	Enoyl-CoA hydratase
A6F65_RS06895	COG0183	Belongs to the thiolase family
A6F65_RS06900	COG0318	PFAM AMP-dependent synthetase and ligase
A6F65_RS06905	COG0789	Transcriptional regulator
A6F65_RS06950	COG0210	DNA helicase
A6F65_RS06970	COG0742	ribosomal rna small subunit methyltransferase
A6F65_RS06980	COG1187	pseudouridine synthase activity
A6F65_RS06985	COG2223	nitrite transmembrane transporter activity
A6F65_RS06990	COG0285	dihydrofolate synthase activity
A6F65_RS06995	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6F65_RS07000	COG0159	tryptophan synthase activity
A6F65_RS07005	COG2852	Protein conserved in bacteria
A6F65_RS07010	COG0133	tryptophan synthase activity
A6F65_RS07015	COG0135	phosphoribosylanthranilate isomerase activity
A6F65_RS07025	COG0284	orotidine-5'-phosphate decarboxylase activity
A6F65_RS07035	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6F65_RS07040	COG2003	Belongs to the UPF0758 family
A6F65_RS07065	COG0356	it plays a direct role in the translocation of protons across the membrane
A6F65_RS07070	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6F65_RS07075	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6F65_RS07080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6F65_RS07090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F65_RS07095	COG0539	negative regulation of cytoplasmic translation
A6F65_RS07105	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6F65_RS07115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6F65_RS07130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6F65_RS07135	COG0228	four-way junction DNA binding
A6F65_RS07140	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6F65_RS07165	COG0336	Belongs to the RNA methyltransferase TrmD family
A6F65_RS07170	COG0335	large ribosomal subunit rRNA binding
A6F65_RS07190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6F65_RS07220	COG4067	protein conserved in archaea
A6F65_RS07220	COG0189	ligase activity
A6F65_RS07225	COG0189	ligase activity
A6F65_RS07240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6F65_RS07245	COG0359	binds to the 23S rRNA
A6F65_RS07250	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6F65_RS07255	COG0360	Binds together with S18 to 16S ribosomal RNA
A6F65_RS07260	COG2354	Protein conserved in bacteria
A6F65_RS07270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6F65_RS07275	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6F65_RS07280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6F65_RS07310	COG0493	'glutamate synthase
A6F65_RS07315	COG3300	MHYT domain
A6F65_RS07315	COG5001	Diguanylate cyclase
A6F65_RS07320	COG3300	MHYT domain
A6F65_RS07320	COG5001	Diguanylate cyclase
A6F65_RS07325	COG0481	GTPase activity
A6F65_RS07350	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6F65_RS07370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6F65_RS07380	COG4221	oxidoreductase activity
A6F65_RS07400	COG2264	protein methyltransferase activity
A6F65_RS07420	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A6F65_RS07455	COG2321	neutral zinc metallopeptidase
A6F65_RS07460	COG1028	Short-chain dehydrogenase reductase Sdr
A6F65_RS07480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6F65_RS07490	COG1051	belongs to the nudix hydrolase family
A6F65_RS07495	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6F65_RS07495	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A6F65_RS07500	COG1013	pyruvate-flavodoxin oxidoreductase activity
A6F65_RS07510	COG1902	pentaerythritol trinitrate reductase activity
A6F65_RS07520	COG0415	Belongs to the DNA photolyase family
A6F65_RS07525	COG2264	protein methyltransferase activity
A6F65_RS07545	COG0300	oxidoreductase activity
A6F65_RS07550	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6F65_RS07560	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6F65_RS07595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6F65_RS07615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6F65_RS07620	COG0126	phosphoglycerate kinase activity
A6F65_RS07630	COG3588	fructose-bisphosphate aldolase
A6F65_RS07640	COG0352	thiamine-phosphate diphosphorylase activity
A6F65_RS07645	COG1376	ErfK ybiS ycfS ynhG family protein
A6F65_RS07650	COG0739	heme binding
A6F65_RS07650	COG1196	nuclear chromosome segregation
A6F65_RS07650	COG0741	lytic transglycosylase activity
A6F65_RS07660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6F65_RS07665	COG0483	inositol monophosphate 1-phosphatase activity
A6F65_RS07690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6F65_RS07695	COG4191	Histidine kinase
A6F65_RS07700	COG2204	response regulator
A6F65_RS07710	COG0385	Bile acid
A6F65_RS07720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6F65_RS07725	COG0733	neurotransmitter:sodium symporter activity
A6F65_RS07735	COG3338	carbonate dehydratase activity
A6F65_RS07745	COG1573	uracil-dna glycosylase
A6F65_RS07750	COG1280	lysine exporter protein (LysE YggA)
A6F65_RS07760	COG0745	RESPONSE REGULATOR receiver
A6F65_RS07765	COG0704	Plays a role in the regulation of phosphate uptake
A6F65_RS07770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6F65_RS07780	COG0573	inorganic phosphate transmembrane transporter activity
A6F65_RS07790	COG3746	phosphate-selective porin O and P
A6F65_RS07795	COG5002	protein histidine kinase activity
A6F65_RS07805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6F65_RS07825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6F65_RS07830	COG2353	YceI-like domain
A6F65_RS07840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6F65_RS07855	COG0028	Belongs to the TPP enzyme family
A6F65_RS07860	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6F65_RS07880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6F65_RS07885	COG1722	exodeoxyribonuclease VII activity
A6F65_RS07890	COG0142	geranyltranstransferase activity
A6F65_RS07900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6F65_RS07910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6F65_RS07920	COG1131	(ABC) transporter
A6F65_RS07925	COG0842	Transport permease protein
A6F65_RS07935	COG0343	queuine tRNA-ribosyltransferase activity
A6F65_RS07945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6F65_RS07970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6F65_RS07975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6F65_RS07980	COG0698	ribose 5-phosphate isomerase
A6F65_RS07985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6F65_RS07990	COG0358	DNA primase activity
A6F65_RS08005	COG0505	Belongs to the CarA family
A6F65_RS08015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6F65_RS08045	COG0148	phosphopyruvate hydratase activity
A6F65_RS08050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6F65_RS08060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6F65_RS08080	COG0772	Belongs to the SEDS family
A6F65_RS08095	COG1792	Involved in formation and maintenance of cell shape
A6F65_RS08105	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6F65_RS08135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6F65_RS08140	COG2867	negative regulation of translational initiation
A6F65_RS08155	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6F65_RS08155	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6F65_RS08165	COG3852	Histidine kinase
A6F65_RS08170	COG2204	response regulator
A6F65_RS08175	COG5000	phosphorelay sensor kinase activity
A6F65_RS08180	COG2204	response regulator
A6F65_RS08190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6F65_RS08195	COG3956	TIGRFAM MazG family protein
A6F65_RS08200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6F65_RS08205	COG1234	tRNA 3'-trailer cleavage
A6F65_RS08210	COG0084	hydrolase, TatD family'
A6F65_RS08220	COG0470	DNA polymerase III
A6F65_RS08225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6F65_RS08230	COG1686	Belongs to the peptidase S11 family
A6F65_RS08235	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6F65_RS08240	COG2951	lytic endotransglycosylase activity
A6F65_RS08255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6F65_RS08265	COG1607	acyl-coa hydrolase
A6F65_RS08270	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F65_RS08285	COG0557	exoribonuclease II activity
A6F65_RS08290	COG0442	prolyl-tRNA aminoacylation
A6F65_RS08300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6F65_RS08315	COG1286	toxin biosynthetic process
A6F65_RS08325	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6F65_RS08330	COG0484	heat shock protein binding
A6F65_RS08335	COG0443	Heat shock 70 kDa protein
A6F65_RS08360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6F65_RS08365	COG1420	regulation of RNA biosynthetic process
A6F65_RS08370	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6F65_RS08375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6F65_RS08385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6F65_RS08390	COG4974	Belongs to the 'phage' integrase family
A6F65_RS08395	COG0586	Pfam SNARE associated Golgi protein
A6F65_RS08400	COG0189	ligase activity
A6F65_RS08405	COG0792	nuclease activity
A6F65_RS08410	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6F65_RS08415	COG3107	peptidoglycan biosynthetic process
A6F65_RS08420	COG0187	DNA topoisomerase II activity
A6F65_RS08450	COG3876	Protein conserved in bacteria
A6F65_RS08460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6F65_RS08480	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6F65_RS08495	COG0574	Belongs to the PEP-utilizing enzyme family
A6F65_RS08495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6F65_RS08500	COG0751	glycine-tRNA ligase activity
A6F65_RS08505	COG0752	glycyl-tRNA synthetase alpha subunit
A6F65_RS08530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6F65_RS08535	COG0193	aminoacyl-tRNA hydrolase activity
A6F65_RS08540	COG0012	GTP binding
A6F65_RS08550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6F65_RS08570	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A6F65_RS08615	COG0022	dehydrogenase e1 component
A6F65_RS08615	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F65_RS08620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6F65_RS08635	COG3088	subunit of a heme lyase
A6F65_RS08640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6F65_RS08645	COG1138	Cytochrome C-type biogenesis protein
A6F65_RS08650	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A6F65_RS08655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6F65_RS08675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6F65_RS08680	COG0071	Belongs to the small heat shock protein (HSP20) family
A6F65_RS08685	COG0504	CTP synthase activity
A6F65_RS08695	COG0149	triose-phosphate isomerase activity
A6F65_RS08705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6F65_RS08730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6F65_RS08735	COG0134	indole-3-glycerol-phosphate synthase activity
A6F65_RS08740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F65_RS08745	COG0315	cyclic pyranopterin monophosphate synthase activity
A6F65_RS08750	COG0303	'Molybdopterin
A6F65_RS08755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6F65_RS08760	COG2333	competence protein COMEC
A6F65_RS08760	COG0658	competence protein
A6F65_RS08765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F65_RS08770	COG0372	Belongs to the citrate synthase family
A6F65_RS08780	COG2205	protein histidine kinase activity
A6F65_RS08815	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A6F65_RS08825	COG1007	ATP synthesis coupled electron transport
A6F65_RS08840	COG0713	ATP synthesis coupled electron transport
A6F65_RS08850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6F65_RS08855	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6F65_RS08885	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A6F65_RS08895	COG0649	NAD binding
A6F65_RS08905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6F65_RS08910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6F65_RS08915	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6F65_RS08920	COG1012	belongs to the aldehyde dehydrogenase family
A6F65_RS08925	COG0183	Belongs to the thiolase family
A6F65_RS08940	COG0004	ammonium transporteR
A6F65_RS08950	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6F65_RS08960	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6F65_RS08975	COG1530	ribonuclease E activity
A6F65_RS08995	COG1216	Glycosyl transferase, family 2
A6F65_RS09005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6F65_RS09010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6F65_RS09020	COG1024	Enoyl-CoA hydratase
A6F65_RS09020	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6F65_RS09050	COG3267	Type II secretory pathway component ExeA
A6F65_RS09050	COG3409	Peptidoglycan-binding domain 1 protein
A6F65_RS09080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6F65_RS09105	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6F65_RS09115	COG0129	dihydroxy-acid dehydratase activity
A6F65_RS09125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6F65_RS09145	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6F65_RS09150	COG0530	calcium, potassium:sodium antiporter activity
A6F65_RS09160	COG0318	PFAM AMP-dependent synthetase and ligase
A6F65_RS09175	COG1136	(ABC) transporter
A6F65_RS09185	COG3706	GGDEF domain
A6F65_RS09190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6F65_RS09200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6F65_RS09210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6F65_RS09220	COG0653	protein targeting
A6F65_RS09245	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A6F65_RS09250	COG0483	inositol monophosphate 1-phosphatase activity
A6F65_RS09270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6F65_RS09275	COG3178	'Phosphotransferase
A6F65_RS09280	COG0802	atpase or kinase
A6F65_RS09285	COG2205	protein histidine kinase activity
A6F65_RS09290	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A6F65_RS09295	COG0678	peroxiredoxin activity
A6F65_RS09310	COG1309	transcriptional regulator
A6F65_RS09315	COG0302	gtp cyclohydrolase
A6F65_RS09320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6F65_RS09355	COG0825	malonyl-CoA metabolic process
A6F65_RS09360	COG4974	Belongs to the 'phage' integrase family
A6F65_RS09370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6F65_RS09375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6F65_RS09390	COG0166	Belongs to the GPI family
A6F65_RS09395	COG0681	Belongs to the peptidase S26 family
A6F65_RS09400	COG0571	ribonuclease III activity
A6F65_RS09405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6F65_RS09415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6F65_RS09415	COG1754	DNA topoisomerase type I activity
A6F65_RS09440	COG0758	DNA mediated transformation
A6F65_RS09445	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6F65_RS09450	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6F65_RS09455	COG0156	8-amino-7-oxononanoate synthase activity
A6F65_RS09460	COG3300	MHYT domain
A6F65_RS09460	COG5001	Diguanylate cyclase
A6F65_RS09470	COG1899	peptidyl-lysine modification to peptidyl-hypusine
A6F65_RS09495	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A6F65_RS09500	COG3387	PFAM Glycoside hydrolase 15-related
A6F65_RS09505	COG1877	trehalose-phosphatase activity
A6F65_RS09525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6F65_RS09530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6F65_RS09535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6F65_RS09545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6F65_RS09555	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6F65_RS09560	COG0583	DNA-binding transcription factor activity
A6F65_RS09570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6F65_RS09575	COG2814	Major facilitator Superfamily
A6F65_RS09580	COG0028	Belongs to the TPP enzyme family
A6F65_RS09590	COG5001	Diguanylate cyclase
A6F65_RS09590	COG3300	MHYT domain
A6F65_RS09595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6F65_RS09600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6F65_RS09605	COG0552	protein localization to endoplasmic reticulum
A6F65_RS09610	COG2917	probably involved in intracellular septation
A6F65_RS09615	COG3158	transport of potassium into the cell
A6F65_RS09640	COG0254	rRNA binding
A6F65_RS09645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6F65_RS09660	COG0750	zinc metalloprotease
A6F65_RS09665	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6F65_RS09675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6F65_RS09680	COG0233	cytoplasmic translational termination
A6F65_RS09685	COG0528	UMP kinase activity
A6F65_RS09700	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6F65_RS09705	COG0052	Belongs to the universal ribosomal protein uS2 family
A6F65_RS09715	COG0688	phosphatidylethanolamine metabolic process
A6F65_RS09725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6F65_RS09755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6F65_RS09770	COG1643	Atp-dependent helicase
A6F65_RS09775	COG0142	geranyltranstransferase activity
A6F65_RS09780	COG1605	Chorismate mutase
A6F65_RS09780	COG0287	Prephenate dehydrogenase
A6F65_RS09785	COG3920	Histidine kinase
A6F65_RS09790	COG0784	Response regulator, receiver
A6F65_RS09815	COG2968	Membrane
A6F65_RS09820	COG0488	(ABC) transporter
A6F65_RS09855	COG0438	transferase activity, transferring glycosyl groups
A6F65_RS09860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6F65_RS09865	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6F65_RS09870	COG1862	Preprotein translocase
A6F65_RS09885	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6F65_RS09890	COG0511	ligase activity, forming carbon-carbon bonds
A6F65_RS09895	COG0439	Biotin carboxylase
A6F65_RS09910	COG1522	sequence-specific DNA binding
A6F65_RS09915	COG2205	protein histidine kinase activity
A6F65_RS09935	COG0534	Mate efflux family protein
A6F65_RS09950	COG2234	aminopeptidase activity
A6F65_RS09990	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A6F65_RS09995	COG0668	transmembrane transport
A6F65_RS10000	COG1199	ATP-dependent helicase activity
A6F65_RS10015	COG0776	regulation of translation
A6F65_RS10020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6F65_RS10025	COG0416	fatty acid biosynthetic process
A6F65_RS10035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F65_RS10040	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A6F65_RS10065	COG0215	cysteine-tRNA ligase activity
A6F65_RS10100	COG2226	methyltransferase
A6F65_RS10115	COG0646	methionine synthase
A6F65_RS10115	COG1410	methionine synthase
A6F65_RS10120	COG1733	regulation of RNA biosynthetic process
A6F65_RS10125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A6F65_RS10130	COG3046	protein related to deoxyribodipyrimidine photolyase
A6F65_RS10140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6F65_RS10175	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6F65_RS10180	COG1012	belongs to the aldehyde dehydrogenase family
A6F65_RS10200	COG0418	dihydroorotase activity
A6F65_RS10225	COG4771	TonB-dependent receptor
A6F65_RS10235	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6F65_RS10240	COG0612	Peptidase, M16
A6F65_RS10250	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6F65_RS10255	COG0047	phosphoribosylformylglycinamidine synthase activity
A6F65_RS10260	COG5001	Diguanylate cyclase
A6F65_RS10265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6F65_RS10275	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6F65_RS10290	COG1045	serine acetyltransferase
A6F65_RS10305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6F65_RS10310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6F65_RS10320	COG0105	UTP biosynthetic process
A6F65_RS10335	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6F65_RS10340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6F65_RS10345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6F65_RS10350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6F65_RS10355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6F65_RS10365	COG3138	arginine N-succinyltransferase
A6F65_RS10370	COG3724	N-succinylarginine dihydrolase activity
A6F65_RS10385	COG1970	mechanosensitive ion channel activity
A6F65_RS10400	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A6F65_RS10410	COG0494	nUDIX hydrolase
A6F65_RS10430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6F65_RS10440	COG2814	Major facilitator Superfamily
A6F65_RS10445	COG1012	belongs to the aldehyde dehydrogenase family
A6F65_RS10465	COG1228	amidohydrolase
A6F65_RS10480	COG1028	Short-chain dehydrogenase reductase Sdr
A6F65_RS10515	COG3971	2-oxopent-4-enoate hydratase activity
A6F65_RS10525	COG1846	Transcriptional regulator
A6F65_RS10555	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A6F65_RS10580	COG4638	Rieske (2fe-2S)
A6F65_RS10600	COG0346	lactoylglutathione lyase activity
A6F65_RS10605	COG0277	FAD linked oxidase domain protein
A6F65_RS10615	COG1028	Short-chain dehydrogenase reductase Sdr
A6F65_RS10690	COG0842	Transport permease protein
A6F65_RS10705	COG1064	alcohol dehydrogenase
A6F65_RS10720	COG1185	polyribonucleotide nucleotidyltransferase activity
A6F65_RS10725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6F65_RS10730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6F65_RS10740	COG1994	Peptidase M50
A6F65_RS10745	COG1435	thymidine kinase activity
A6F65_RS10755	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6F65_RS10770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6F65_RS10775	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A6F65_RS10785	COG0779	Required for maturation of 30S ribosomal subunits
A6F65_RS10805	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6F65_RS10810	COG1842	Phage shock protein A
A6F65_RS10840	COG2166	iron-sulfur cluster assembly
A6F65_RS10845	COG0401	homolog of Blt101
A6F65_RS10865	COG0824	Thioesterase
A6F65_RS10875	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6F65_RS10890	COG0066	3-isopropylmalate dehydratase activity
A6F65_RS10900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6F65_RS10915	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6F65_RS10925	COG4181	ATPase activity
A6F65_RS10935	COG4771	TonB-dependent receptor
A6F65_RS10940	COG5658	integral membrane protein
A6F65_RS10945	COG0640	Transcriptional regulator
A6F65_RS10960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6F65_RS10975	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A6F65_RS10980	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6F65_RS10995	COG2897	thiosulfate sulfurtransferase activity
A6F65_RS11000	COG0626	cystathionine gamma-synthase activity
A6F65_RS11005	COG0668	transmembrane transport
A6F65_RS11010	COG1648	precorrin-2 dehydrogenase activity
A6F65_RS11010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6F65_RS11020	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6F65_RS11030	COG0175	sulfate reduction
A6F65_RS11040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6F65_RS11045	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6F65_RS11050	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6F65_RS11060	COG0670	Belongs to the BI1 family
A6F65_RS11065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6F65_RS11090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6F65_RS11095	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6F65_RS11100	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6F65_RS11105	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6F65_RS11110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6F65_RS11120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6F65_RS11125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6F65_RS11130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6F65_RS11135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6F65_RS11150	COG0275	rRNA processing
A6F65_RS11155	COG2001	Belongs to the MraZ family
A6F65_RS11170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6F65_RS11200	COG2154	pterin-4-alpha-carbinolamine dehydratase
A6F65_RS11205	COG4133	protoheme IX ABC transporter activity
A6F65_RS11210	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6F65_RS11215	COG0024	Methionine aminopeptidase
A6F65_RS11225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6F65_RS11235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6F65_RS11240	COG0347	Belongs to the P(II) protein family
A6F65_RS11245	COG0174	glutamine synthetase
A6F65_RS11255	COG1476	TRANSCRIPTIONal
A6F65_RS11285	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A6F65_RS11290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6F65_RS11295	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A6F65_RS11300	COG0805	protein transport
A6F65_RS11305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6F65_RS11310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6F65_RS11315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6F65_RS11320	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6F65_RS11325	COG1472	Belongs to the glycosyl hydrolase 3 family
A6F65_RS11335	COG0018	arginyl-trna synthetase
A6F65_RS11345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6F65_RS11350	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6F65_RS11355	COG0328	RNA-DNA hybrid ribonuclease activity
A6F65_RS11360	COG3422	double-strand break repair
A6F65_RS11385	COG4964	Belongs to the GSP D family
A6F65_RS11415	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A6F65_RS11460	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6F65_RS11470	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6F65_RS11485	COG0154	amidase activity
A6F65_RS11490	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6F65_RS11505	COG0545	Peptidyl-prolyl cis-trans isomerase
A6F65_RS11510	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6F65_RS11515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6F65_RS11525	COG0546	phosphoglycolate phosphatase activity
A6F65_RS11545	COG1127	ABC transporter
A6F65_RS11550	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6F65_RS11555	COG0525	valine-tRNA ligase activity
A6F65_RS11565	COG0602	queuosine metabolic process
A6F65_RS11585	COG0730	response to heat
A6F65_RS11595	COG1215	transferase activity, transferring glycosyl groups
A6F65_RS11600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6F65_RS11615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6F65_RS11625	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6F65_RS11640	COG0564	pseudouridine synthase activity
A6F65_RS11645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6F65_RS11660	COG1595	DNA-templated transcription, initiation
A6F65_RS11670	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6F65_RS11690	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6F65_RS11695	COG0740	serine-type endopeptidase activity
A6F65_RS11705	COG0154	amidase activity
A6F65_RS11715	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6F65_RS11740	COG1160	GTP binding
A6F65_RS11760	COG2311	Membrane
A6F65_RS11785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6F65_RS11790	COG0540	Belongs to the ATCase OTCase family
A6F65_RS11795	COG0616	signal peptide processing
A6F65_RS11810	COG0438	transferase activity, transferring glycosyl groups
A6F65_RS11815	COG0438	transferase activity, transferring glycosyl groups
A6F65_RS11845	COG3665	Urea carboxylase-associated protein
A6F65_RS11880	COG4974	Belongs to the 'phage' integrase family
A6F65_RS11945	COG2197	response regulator
A6F65_RS11960	COG2239	Acts as a magnesium transporter
A6F65_RS11965	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A6F65_RS11980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6F65_RS11990	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6F65_RS11995	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6F65_RS12015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6F65_RS12040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6F65_RS12045	COG0129	dihydroxy-acid dehydratase activity
A6F65_RS12050	COG0837	glucose binding
A6F65_RS12055	COG0800	Aldolase
A6F65_RS12070	COG0037	tRNA processing
A6F65_RS12100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6F65_RS12165	COG0321	lipoyl(octanoyl) transferase activity
A6F65_RS12185	COG4774	siderophore transport
A6F65_RS12190	COG2080	2 iron, 2 sulfur cluster binding
A6F65_RS12195	COG0534	Mate efflux family protein
A6F65_RS12200	COG1012	belongs to the aldehyde dehydrogenase family
A6F65_RS12205	COG0725	ABC transporter, periplasmic molybdate-binding protein
A6F65_RS12210	COG4149	molybdate abc transporter
A6F65_RS12215	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A6F65_RS12220	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6F65_RS12225	COG0248	Ppx GppA phosphatase
A6F65_RS12250	COG0745	RESPONSE REGULATOR receiver
A6F65_RS12255	COG0436	Aminotransferase
A6F65_RS12260	COG3243	poly(R)-hydroxyalkanoic acid synthase
A6F65_RS12305	COG0784	Response regulator, receiver
A6F65_RS12310	COG3920	Histidine kinase
A6F65_RS12310	COG2202	Pas domain
A6F65_RS12335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6F65_RS12340	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6F65_RS12340	COG0351	phosphomethylpyrimidine kinase
A6F65_RS12340	COG0352	thiamine-phosphate diphosphorylase activity
A6F65_RS12345	COG1611	Belongs to the LOG family
A6F65_RS12360	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6F65_RS12365	COG3474	cytochrome
A6F65_RS12370	COG0077	Prephenate dehydratase
A6F65_RS12385	COG0714	Associated with various cellular activities
A6F65_RS12405	COG0454	-acetyltransferase
A6F65_RS12415	COG0668	transmembrane transport
A6F65_RS12435	COG2067	long-chain fatty acid transport protein
A6F65_RS12440	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6F65_RS12450	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6F65_RS12465	COG2989	Protein conserved in bacteria
A6F65_RS12480	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A6F65_RS12505	COG2255	four-way junction helicase activity
A6F65_RS12515	COG0632	four-way junction helicase activity
A6F65_RS12520	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6F65_RS12530	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A6F65_RS12555	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A6F65_RS12560	COG0728	peptidoglycan biosynthetic process
A6F65_RS12565	COG0180	Tryptophanyl-tRNA synthetase
A6F65_RS12585	COG0756	dUTP diphosphatase activity
A6F65_RS12590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6F65_RS12610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6F65_RS12615	COG2226	methyltransferase
A6F65_RS12620	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6F65_RS12625	COG0268	Binds directly to 16S ribosomal RNA