locus-tag	class	description
B1781_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B1781_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B1781_RS00020	COG0187	DNA topoisomerase II activity
B1781_RS00030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B1781_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
B1781_RS00070	COG0174	glutamine synthetase
B1781_RS00080	COG3852	Histidine kinase
B1781_RS00085	COG2204	response regulator
B1781_RS00095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B1781_RS00095	COG0426	domain, Protein
B1781_RS00135	COG0167	dihydroorotate dehydrogenase activity
B1781_RS00140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B1781_RS00165	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1781_RS00195	COG0778	Nitroreductase
B1781_RS00210	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B1781_RS00215	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B1781_RS00220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B1781_RS00230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B1781_RS00240	COG0793	Belongs to the peptidase S41A family
B1781_RS00245	COG2861	carbohydrate metabolic process
B1781_RS00260	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B1781_RS00285	COG3122	Protein conserved in bacteria
B1781_RS00290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B1781_RS00320	COG0471	metal ion transport
B1781_RS00320	COG3273	potassium ion transport
B1781_RS00325	COG0501	Belongs to the peptidase M48B family
B1781_RS00355	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B1781_RS00355	COG1013	pyruvate-flavodoxin oxidoreductase activity
B1781_RS00355	COG0674	pyruvate-flavodoxin oxidoreductase activity
B1781_RS00355	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B1781_RS00370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1781_RS00375	COG2197	response regulator
B1781_RS00515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B1781_RS00525	COG0019	diaminopimelate decarboxylase activity
B1781_RS00560	COG2972	Histidine kinase
B1781_RS00560	COG0745	RESPONSE REGULATOR receiver
B1781_RS00580	COG5002	protein histidine kinase activity
B1781_RS00580	COG5001	Diguanylate cyclase
B1781_RS00590	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B1781_RS00600	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B1781_RS00605	COG1704	LemA family
B1781_RS00655	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B1781_RS00675	COG0840	transmembrane signaling receptor activity
B1781_RS00690	COG3038	cytochrome b561
B1781_RS00700	COG2814	Major facilitator Superfamily
B1781_RS00720	COG0247	lactate metabolic process
B1781_RS00725	COG1011	Hydrolase
B1781_RS00760	COG0543	2 iron, 2 sulfur cluster binding
B1781_RS00760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1781_RS00770	COG2959	enzyme of heme biosynthesis
B1781_RS00780	COG0181	hydroxymethylbilane synthase activity
B1781_RS00800	COG0408	coproporphyrinogen oxidase activity
B1781_RS00810	COG0009	L-threonylcarbamoyladenylate synthase
B1781_RS00820	COG2922	Belongs to the Smg family
B1781_RS00825	COG0758	DNA mediated transformation
B1781_RS00830	COG1652	LysM domain
B1781_RS00835	COG0242	peptide deformylase activity
B1781_RS00855	COG5000	phosphorelay sensor kinase activity
B1781_RS00860	COG2204	response regulator
B1781_RS00865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B1781_RS00875	COG0569	domain protein
B1781_RS00880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B1781_RS00900	COG0315	cyclic pyranopterin monophosphate synthase activity
B1781_RS00915	COG0671	phosphoesterase, PA-phosphatase related
B1781_RS00915	COG2453	phosphatase
B1781_RS00920	COG2267	carboxylic ester hydrolase activity
B1781_RS00925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B1781_RS00930	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B1781_RS00935	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B1781_RS00945	COG5001	Diguanylate cyclase
B1781_RS00950	COG0205	6-phosphofructokinase activity
B1781_RS00960	COG0563	adenylate kinase activity
B1781_RS00975	COG0312	modulator of DNA gyrase
B1781_RS00980	COG0312	modulator of DNA gyrase
B1781_RS00985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1781_RS01000	COG0424	maF-like protein
B1781_RS01015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B1781_RS01020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B1781_RS01035	COG2308	Evidence 4 Homologs of previously reported genes of
B1781_RS01055	COG0495	leucyl-tRNA aminoacylation
B1781_RS01075	COG2239	Acts as a magnesium transporter
B1781_RS01080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1781_RS01085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1781_RS01095	COG1660	Displays ATPase and GTPase activities
B1781_RS01100	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B1781_RS01120	COG1137	ATPase activity
B1781_RS01135	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B1781_RS01140	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B1781_RS01140	COG0517	IMP dehydrogenase activity
B1781_RS01160	COG1127	ABC transporter
B1781_RS01165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B1781_RS01170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B1781_RS01175	COG2854	intermembrane phospholipid transfer
B1781_RS01185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B1781_RS01190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B1781_RS01195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B1781_RS01205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1781_RS01230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1781_RS01235	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B1781_RS01240	COG0723	plastoquinol--plastocyanin reductase activity
B1781_RS01245	COG0723	plastoquinol--plastocyanin reductase activity
B1781_RS01250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B1781_RS01255	COG2857	Cytochrome c1
B1781_RS01260	COG0625	glutathione transferase activity
B1781_RS01265	COG2969	positive regulation of protein catabolic process
B1781_RS01275	COG2244	polysaccharide biosynthetic process
B1781_RS01290	COG0390	transport system, permease component
B1781_RS01295	COG1116	anion transmembrane transporter activity
B1781_RS01300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B1781_RS01305	COG2022	thiamine diphosphate biosynthetic process
B1781_RS01315	COG1022	Amp-dependent synthetase and ligase
B1781_RS01325	COG1999	signal sequence binding
B1781_RS01340	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B1781_RS01365	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B1781_RS01370	COG2244	polysaccharide biosynthetic process
B1781_RS01375	COG1028	Short-chain dehydrogenase reductase Sdr
B1781_RS01390	COG0577	efflux transmembrane transporter activity
B1781_RS01390	COG1136	(ABC) transporter
B1781_RS01395	COG0577	efflux transmembrane transporter activity
B1781_RS01395	COG1136	(ABC) transporter
B1781_RS01400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1781_RS01410	COG0800	Aldolase
B1781_RS01425	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
B1781_RS01430	COG1116	anion transmembrane transporter activity
B1781_RS01440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1781_RS01465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1781_RS01475	COG0438	transferase activity, transferring glycosyl groups
B1781_RS01490	COG2205	protein histidine kinase activity
B1781_RS01490	COG0784	Response regulator, receiver
B1781_RS01540	COG1011	Hydrolase
B1781_RS01545	COG3300	MHYT domain
B1781_RS01545	COG5001	Diguanylate cyclase
B1781_RS01570	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B1781_RS01575	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B1781_RS01595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B1781_RS01600	COG0306	phosphate transporter
B1781_RS01610	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B1781_RS01615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B1781_RS01620	COG0330	HflC and HflK could
B1781_RS01650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B1781_RS01655	COG0037	tRNA processing
B1781_RS01710	COG1088	dTDP-glucose 4,6-dehydratase activity
B1781_RS01720	COG0463	Glycosyl transferase, family 2
B1781_RS01725	COG0438	transferase activity, transferring glycosyl groups
B1781_RS01760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B1781_RS01770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B1781_RS01775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1781_RS01785	COG0151	Belongs to the GarS family
B1781_RS01790	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1781_RS01810	COG0138	bifunctional purine biosynthesis protein purh
B1781_RS01820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B1781_RS01830	COG2264	protein methyltransferase activity
B1781_RS01835	COG0439	Biotin carboxylase
B1781_RS01840	COG0511	ligase activity, forming carbon-carbon bonds
B1781_RS01845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B1781_RS01850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1781_RS01855	COG4232	protein-disulfide reductase activity
B1781_RS01860	COG1324	tolerance protein
B1781_RS01875	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B1781_RS01885	COG2208	phosphoserine phosphatase activity
B1781_RS01895	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B1781_RS01915	COG0859	PFAM glycosyl transferase family 9
B1781_RS01920	COG0438	transferase activity, transferring glycosyl groups
B1781_RS01940	COG2192	nodulation
B1781_RS01945	COG0438	transferase activity, transferring glycosyl groups
B1781_RS01950	COG0438	transferase activity, transferring glycosyl groups
B1781_RS01965	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B1781_RS01980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1781_RS01995	COG0438	transferase activity, transferring glycosyl groups
B1781_RS02000	COG0438	transferase activity, transferring glycosyl groups
B1781_RS02005	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B1781_RS02005	COG2755	lipolytic protein G-D-S-L family
B1781_RS02015	COG1560	Kdo2-lipid A biosynthetic process
B1781_RS02020	COG1132	(ABC) transporter
B1781_RS02040	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B1781_RS02040	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B1781_RS02050	COG4989	oxidoreductase activity
B1781_RS02055	COG1519	Transferase
B1781_RS02065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B1781_RS02085	COG2815	serine threonine protein kinase
B1781_RS02085	COG0515	serine threonine protein kinase
B1781_RS02110	COG0631	protein serine/threonine phosphatase activity
B1781_RS02270	COG0247	lactate metabolic process
B1781_RS02285	COG2199	diguanylate cyclase activity
B1781_RS02310	COG1187	pseudouridine synthase activity
B1781_RS02360	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B1781_RS02375	COG0501	Belongs to the peptidase M48B family
B1781_RS02380	COG2832	Protein of unknown function (DUF454)
B1781_RS02395	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B1781_RS02400	COG3842	ATPase activity
B1781_RS02405	COG1176	ABC-type spermidine putrescine transport system, permease component I
B1781_RS02410	COG1177	transmembrane transport
B1781_RS02420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B1781_RS02420	COG2169	Transcriptional regulator
B1781_RS02440	COG0028	Belongs to the TPP enzyme family
B1781_RS02450	COG3284	Transcriptional regulator
B1781_RS02455	COG1012	belongs to the aldehyde dehydrogenase family
B1781_RS02465	COG0584	glycerophosphoryl diester phosphodiesterase
B1781_RS02470	COG2354	Protein conserved in bacteria
B1781_RS02490	COG1830	Aldolase
B1781_RS02495	COG2995	paraquat-inducible protein a
B1781_RS02500	COG2995	paraquat-inducible protein a
B1781_RS02505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B1781_RS02505	COG3008	intermembrane lipid transfer
B1781_RS02605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1781_RS02610	COG1138	Cytochrome C-type biogenesis protein
B1781_RS02615	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B1781_RS02625	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B1781_RS02635	COG4133	protoheme IX ABC transporter activity
B1781_RS02645	COG3245	cytochrome
B1781_RS02655	COG2084	Dehydrogenase
B1781_RS02670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B1781_RS02675	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B1781_RS02680	COG0631	protein serine/threonine phosphatase activity
B1781_RS02685	COG0515	serine threonine protein kinase
B1781_RS02690	COG1561	YicC-like family, N-terminal region
B1781_RS02695	COG0438	transferase activity, transferring glycosyl groups
B1781_RS02730	COG0194	GDP metabolic process
B1781_RS02735	COG1758	RNA polymerase activity
B1781_RS02740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B1781_RS02745	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B1781_RS02755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B1781_RS02770	COG0586	Pfam SNARE associated Golgi protein
B1781_RS02775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B1781_RS02780	COG0352	thiamine-phosphate diphosphorylase activity
B1781_RS02785	COG0351	phosphomethylpyrimidine kinase
B1781_RS02790	COG1773	rubredoxin
B1781_RS02800	COG0316	Belongs to the HesB IscA family
B1781_RS02810	COG1981	membrane
B1781_RS02825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B1781_RS02840	COG0316	Belongs to the HesB IscA family
B1781_RS02845	COG0045	succinate-CoA ligase (ADP-forming) activity
B1781_RS02845	COG1042	CoA-binding domain protein
B1781_RS02845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B1781_RS02850	COG0123	including yeast histone deacetylase and acetoin utilization protein
B1781_RS02865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B1781_RS02900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1781_RS02905	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B1781_RS02905	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B1781_RS02910	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B1781_RS02950	COG4251	negative regulation of phosphorylation
B1781_RS02960	COG0784	Response regulator, receiver
B1781_RS02970	COG0745	RESPONSE REGULATOR receiver
B1781_RS02975	COG2198	Histidine kinase
B1781_RS02975	COG0643	Histidine kinase
B1781_RS02980	COG0835	chemotaxis
B1781_RS02985	COG0840	transmembrane signaling receptor activity
B1781_RS02990	COG0840	transmembrane signaling receptor activity
B1781_RS02990	COG0840	transmembrane signaling receptor activity
B1781_RS03000	COG1192	Involved in chromosome partitioning
B1781_RS03020	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B1781_RS03025	COG2201	protein-glutamate methylesterase activity
B1781_RS03030	COG0840	transmembrane signaling receptor activity
B1781_RS03045	COG0012	GTP binding
B1781_RS03060	COG0004	ammonium transporteR
B1781_RS03075	COG0142	geranyltranstransferase activity
B1781_RS03080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B1781_RS03085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B1781_RS03090	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B1781_RS03095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B1781_RS03100	COG0268	Binds directly to 16S ribosomal RNA
B1781_RS03105	COG0728	peptidoglycan biosynthetic process
B1781_RS03110	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B1781_RS03115	COG0196	riboflavin kinase activity
B1781_RS03120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B1781_RS03125	COG0745	RESPONSE REGULATOR receiver
B1781_RS03130	COG2205	protein histidine kinase activity
B1781_RS03135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B1781_RS03140	COG3023	N-Acetylmuramoyl-L-alanine amidase
B1781_RS03170	COG0545	Peptidyl-prolyl cis-trans isomerase
B1781_RS03175	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B1781_RS03185	COG0271	Belongs to the BolA IbaG family
B1781_RS03200	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B1781_RS03205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1781_RS03215	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B1781_RS03225	COG0729	surface antigen
B1781_RS03230	COG2911	Protein conserved in bacteria
B1781_RS03295	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B1781_RS03300	COG1047	Peptidyl-prolyl cis-trans
B1781_RS03310	COG2096	Adenosyltransferase
B1781_RS03325	COG3118	belongs to the thioredoxin family
B1781_RS03330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1781_RS03365	COG2193	ferroxidase activity
B1781_RS03405	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B1781_RS03410	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B1781_RS03415	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B1781_RS03425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B1781_RS03445	COG4181	ATPase activity
B1781_RS03455	COG1477	protein flavinylation
B1781_RS03470	COG4251	negative regulation of phosphorylation
B1781_RS03490	COG0850	regulation of cytokinetic process
B1781_RS03495	COG2894	cell division
B1781_RS03530	COG0861	Integral membrane protein TerC family
B1781_RS03535	COG0604	alcohol dehydrogenase
B1781_RS03545	COG0659	secondary active sulfate transmembrane transporter activity
B1781_RS03550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B1781_RS03550	COG4651	solute:proton antiporter activity
B1781_RS03555	COG3300	MHYT domain
B1781_RS03555	COG5001	Diguanylate cyclase
B1781_RS03595	COG0058	SHG alpha-glucan phosphorylase activity
B1781_RS03600	COG0297	glycogen (starch) synthase activity
B1781_RS03605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B1781_RS03620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B1781_RS03625	COG0837	glucose binding
B1781_RS03630	COG0363	glucosamine-6-phosphate deaminase activity
B1781_RS03635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B1781_RS03640	COG0166	Belongs to the GPI family
B1781_RS03650	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B1781_RS03655	COG3273	potassium ion transport
B1781_RS03655	COG0471	metal ion transport
B1781_RS03665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1781_RS03665	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B1781_RS03700	COG0129	dihydroxy-acid dehydratase activity
B1781_RS03710	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1781_RS03720	COG3842	ATPase activity
B1781_RS03725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B1781_RS03730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1781_RS03735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B1781_RS03745	COG0367	asparagine synthase
B1781_RS03750	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B1781_RS03755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B1781_RS03780	COG1238	metal cluster binding
B1781_RS03790	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1781_RS03795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1781_RS03825	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B1781_RS03830	COG0596	Alpha beta hydrolase
B1781_RS03850	COG0577	efflux transmembrane transporter activity
B1781_RS03850	COG1136	(ABC) transporter
B1781_RS03855	COG1136	(ABC) transporter
B1781_RS03855	COG0577	efflux transmembrane transporter activity
B1781_RS03860	COG0577	efflux transmembrane transporter activity
B1781_RS03860	COG1136	(ABC) transporter
B1781_RS03865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1781_RS03885	COG0137	argininosuccinate synthase activity
B1781_RS03890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1781_RS03900	COG1546	Belongs to the CinA family
B1781_RS03900	COG1058	Belongs to the CinA family
B1781_RS03905	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B1781_RS03910	COG0668	transmembrane transport
B1781_RS03945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B1781_RS03950	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B1781_RS03955	COG0517	IMP dehydrogenase activity
B1781_RS03955	COG0516	GMP reductase activity
B1781_RS03985	COG0248	Ppx GppA phosphatase
B1781_RS04030	COG0300	oxidoreductase activity
B1781_RS04055	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B1781_RS04060	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1781_RS04070	COG2204	response regulator
B1781_RS04075	COG3852	Histidine kinase
B1781_RS04100	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1781_RS04105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B1781_RS04120	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B1781_RS04125	COG4988	ABC transporter
B1781_RS04130	COG0583	DNA-binding transcription factor activity
B1781_RS04145	COG2197	response regulator
B1781_RS04150	COG3850	Histidine kinase
B1781_RS04165	COG1294	oxidase, subunit
B1781_RS04185	COG0488	(ABC) transporter
B1781_RS04220	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
B1781_RS04460	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B1781_RS04485	COG0456	acetyltransferase
B1781_RS04725	COG1280	lysine exporter protein (LysE YggA)
B1781_RS04860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B1781_RS04940	COG2963	transposase activity
B1781_RS05100	COG3437	response regulator, receiver
B1781_RS05105	COG1215	transferase activity, transferring glycosyl groups
B1781_RS05110	COG3769	mannosylglycerate metabolic process
B1781_RS05120	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B1781_RS05120	COG2885	chlorophyll binding
B1781_RS05175	COG4783	chaperone-mediated protein folding
B1781_RS05225	COG1012	belongs to the aldehyde dehydrogenase family
B1781_RS05230	COG0438	transferase activity, transferring glycosyl groups
B1781_RS05245	COG3128	pkhd-type hydroxylase
B1781_RS05260	COG1028	Short-chain dehydrogenase reductase Sdr
B1781_RS05265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1781_RS05275	COG1021	2,3-dihydroxybenzoate-AMP ligase
B1781_RS05280	COG1169	isochorismate synthase
B1781_RS05315	COG2221	Nitrite and sulphite reductase 4Fe-4S
B1781_RS05320	COG2221	Nitrite and sulphite reductase 4Fe-4S
B1781_RS05325	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
B1781_RS05330	COG2923	Belongs to the DsrF TusC family
B1781_RS05340	COG2920	part of a sulfur-relay system
B1781_RS05375	COG1797	cobyrinic acid a,c-diamide synthase activity
B1781_RS05395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1781_RS05395	COG0543	2 iron, 2 sulfur cluster binding
B1781_RS05405	COG2863	cytochrome
B1781_RS05415	COG3062	negative regulation of establishment of protein localization
B1781_RS05420	COG0243	molybdopterin cofactor binding
B1781_RS05425	COG0437	4 iron, 4 sulfur cluster binding
B1781_RS05430	COG0348	domain, Protein
B1781_RS05450	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B1781_RS05460	COG0308	aminopeptidase N
B1781_RS05470	COG1047	Peptidyl-prolyl cis-trans
B1781_RS05480	COG3153	acetyltransferase
B1781_RS05495	COG1671	Belongs to the UPF0178 family
B1781_RS05515	COG0811	peptide transport
B1781_RS05535	COG0745	RESPONSE REGULATOR receiver
B1781_RS05540	COG5002	protein histidine kinase activity
B1781_RS05550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B1781_RS05560	COG5265	(ABC) transporter
B1781_RS05570	COG3850	Histidine kinase
B1781_RS05575	COG2197	response regulator
B1781_RS05585	COG1648	precorrin-2 dehydrogenase activity
B1781_RS05585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B1781_RS05590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B1781_RS05595	COG0425	Belongs to the sulfur carrier protein TusA family
B1781_RS05600	COG2210	Belongs to the sulfur carrier protein TusA family
B1781_RS05610	COG0583	DNA-binding transcription factor activity
B1781_RS05630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1781_RS05640	COG0784	Response regulator, receiver
B1781_RS05640	COG2205	protein histidine kinase activity
B1781_RS05640	COG5002	protein histidine kinase activity
B1781_RS05645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B1781_RS05650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B1781_RS05655	COG2716	regulation of RNA biosynthetic process
B1781_RS05665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1781_RS05670	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
B1781_RS05675	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B1781_RS05680	COG0047	phosphoribosylformylglycinamidine synthase activity
B1781_RS05680	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B1781_RS05685	COG2900	Belongs to the SlyX family
B1781_RS05700	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B1781_RS05705	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B1781_RS05740	COG0488	(ABC) transporter
B1781_RS05750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1781_RS05755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B1781_RS05775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1781_RS05780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B1781_RS05785	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B1781_RS05785	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B1781_RS05810	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B1781_RS05815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B1781_RS05825	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B1781_RS05830	COG3577	Aspartyl protease
B1781_RS05835	COG1469	GTP cyclohydrolase I activity
B1781_RS05840	COG0142	geranyltranstransferase activity
B1781_RS05845	COG1722	exodeoxyribonuclease VII activity
B1781_RS05880	COG5002	protein histidine kinase activity
B1781_RS05880	COG5001	Diguanylate cyclase
B1781_RS05885	COG0709	Synthesizes selenophosphate from selenide and ATP
B1781_RS05915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1781_RS05930	COG0347	Belongs to the P(II) protein family
B1781_RS05970	COG1131	(ABC) transporter
B1781_RS06005	COG0300	oxidoreductase activity
B1781_RS06020	COG3842	ATPase activity
B1781_RS06025	COG1175	transmembrane transport
B1781_RS06030	COG0395	ABC-type sugar transport system, permease component
B1781_RS06035	COG1653	transport
B1781_RS06040	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B1781_RS06065	COG0676	glucose-6-phosphate 1-epimerase activity
B1781_RS06085	COG0745	RESPONSE REGULATOR receiver
B1781_RS06105	COG3706	GGDEF domain
B1781_RS06110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1781_RS06130	COG1199	ATP-dependent helicase activity
B1781_RS06140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1781_RS06145	COG1280	lysine exporter protein (LysE YggA)
B1781_RS06150	COG0659	secondary active sulfate transmembrane transporter activity
B1781_RS06155	COG0432	Pfam Uncharacterised protein family UPF0047
B1781_RS06180	COG1214	PFAM Peptidase M22, glycoprotease
B1781_RS06185	COG2925	Exonuclease
B1781_RS06195	COG2885	chlorophyll binding
B1781_RS06200	COG3743	rRNA binding
B1781_RS06200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B1781_RS06305	COG2827	Endonuclease containing a URI domain
B1781_RS06340	COG3091	SprT-like family
B1781_RS06345	COG0302	gtp cyclohydrolase
B1781_RS06365	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1781_RS06370	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1781_RS06375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B1781_RS06375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1781_RS06380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1781_RS06390	COG0189	ligase activity
B1781_RS06395	COG1595	DNA-templated transcription, initiation
B1781_RS06405	COG2239	Acts as a magnesium transporter
B1781_RS06410	COG1253	flavin adenine dinucleotide binding
B1781_RS06415	COG3707	response regulator
B1781_RS06420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B1781_RS06420	COG1116	anion transmembrane transporter activity
B1781_RS06425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1781_RS06430	COG1116	anion transmembrane transporter activity
B1781_RS06435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B1781_RS06435	COG1116	anion transmembrane transporter activity
B1781_RS06440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1781_RS06450	COG2920	part of a sulfur-relay system
B1781_RS06455	COG0243	molybdopterin cofactor binding
B1781_RS06460	COG1763	Mo-molybdopterin cofactor biosynthetic process
B1781_RS06490	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B1781_RS06505	COG1940	carbohydrate kinase activity
B1781_RS06560	COG1509	lysine 2,3-aminomutase activity
B1781_RS06565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B1781_RS06580	COG0688	phosphatidylethanolamine metabolic process
B1781_RS06590	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B1781_RS06595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1781_RS06625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B1781_RS06630	COG1121	(ABC) transporter
B1781_RS06635	COG0735	belongs to the Fur family
B1781_RS06655	COG2201	protein-glutamate methylesterase activity
B1781_RS06665	COG5001	Diguanylate cyclase
B1781_RS06665	COG5002	protein histidine kinase activity
B1781_RS06675	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B1781_RS06680	COG0343	queuine tRNA-ribosyltransferase activity
B1781_RS06685	COG1862	Preprotein translocase
B1781_RS06690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1781_RS06695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1781_RS06705	COG0438	transferase activity, transferring glycosyl groups
B1781_RS06710	COG2873	o-acetylhomoserine
B1781_RS06715	COG0840	transmembrane signaling receptor activity
B1781_RS06740	COG0730	response to heat
B1781_RS06750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1781_RS06755	COG1131	(ABC) transporter
B1781_RS06760	COG0842	Transport permease protein
B1781_RS06765	COG2270	Major facilitator Superfamily
B1781_RS06770	COG2738	Putative neutral zinc metallopeptidase
B1781_RS06800	COG1987	bacterial-type flagellum assembly
B1781_RS06810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B1781_RS06815	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B1781_RS06840	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
B1781_RS06845	COG0643	Histidine kinase
B1781_RS06845	COG0784	Response regulator, receiver
B1781_RS06845	COG2198	Histidine kinase
B1781_RS06850	COG2201	protein-glutamate methylesterase activity
B1781_RS06855	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B1781_RS06865	COG1192	Involved in chromosome partitioning
B1781_RS06875	COG0835	chemotaxis
B1781_RS06890	COG0668	transmembrane transport
B1781_RS06915	COG0204	Acyl-transferase
B1781_RS06920	COG3239	Fatty acid desaturase
B1781_RS06925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1781_RS06950	COG5001	Diguanylate cyclase
B1781_RS07065	COG0535	radical SAM domain protein
B1781_RS07080	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B1781_RS07100	COG1131	(ABC) transporter
B1781_RS07105	COG0842	Transport permease protein
B1781_RS07110	COG0842	Transport permease protein
B1781_RS07115	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
B1781_RS07115	COG2878	Part of a membrane complex involved in electron transport
B1781_RS07120	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B1781_RS07120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B1781_RS07120	COG1013	pyruvate-flavodoxin oxidoreductase activity
B1781_RS07120	COG0674	pyruvate-flavodoxin oxidoreductase activity
B1781_RS07125	COG4656	Part of a membrane complex involved in electron transport
B1781_RS07130	COG4658	electron transport chain
B1781_RS07140	COG4660	Part of a membrane complex involved in electron transport
B1781_RS07145	COG4657	Part of a membrane complex involved in electron transport
B1781_RS07160	COG1858	cytochrome C peroxidase
B1781_RS07165	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B1781_RS07175	COG0840	transmembrane signaling receptor activity
B1781_RS07205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B1781_RS07210	COG0840	transmembrane signaling receptor activity
B1781_RS07225	COG0583	DNA-binding transcription factor activity
B1781_RS07245	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B1781_RS07270	COG4658	electron transport chain
B1781_RS07275	COG4656	Part of a membrane complex involved in electron transport
B1781_RS07280	COG2878	Part of a membrane complex involved in electron transport
B1781_RS07285	COG4657	Part of a membrane complex involved in electron transport
B1781_RS07320	COG0426	domain, Protein
B1781_RS07325	COG0633	Ferredoxin
B1781_RS07355	COG2703	oxygen carrier activity
B1781_RS07375	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
B1781_RS07395	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B1781_RS07450	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
B1781_RS07530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B1781_RS07545	COG5002	protein histidine kinase activity
B1781_RS07545	COG2205	protein histidine kinase activity
B1781_RS07545	COG0784	Response regulator, receiver
B1781_RS07550	COG0745	RESPONSE REGULATOR receiver
B1781_RS07560	COG5002	protein histidine kinase activity
B1781_RS07565	COG0745	RESPONSE REGULATOR receiver
B1781_RS07570	COG2202	Pas domain
B1781_RS07570	COG2205	protein histidine kinase activity
B1781_RS07600	COG2205	protein histidine kinase activity
B1781_RS07600	COG0784	Response regulator, receiver
B1781_RS07600	COG5002	protein histidine kinase activity
B1781_RS07605	COG0840	transmembrane signaling receptor activity
B1781_RS07690	COG2267	carboxylic ester hydrolase activity
B1781_RS07700	COG4569	acetaldehyde dehydrogenase (acetylating) activity
B1781_RS07750	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B1781_RS07755	COG0436	Aminotransferase
B1781_RS07770	COG1509	lysine 2,3-aminomutase activity
B1781_RS07785	COG3267	Type II secretory pathway component ExeA
B1781_RS07785	COG3409	Peptidoglycan-binding domain 1 protein
B1781_RS07810	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
B1781_RS07815	COG1017	nitric oxide dioxygenase activity
B1781_RS07815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1781_RS07830	COG0754	glutathionylspermidine amidase activity
B1781_RS07845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B1781_RS07850	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B1781_RS07855	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B1781_RS07860	COG0537	adenosine 5'-monophosphoramidase activity
B1781_RS07870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B1781_RS07905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1781_RS07910	COG1393	Belongs to the ArsC family
B1781_RS07915	COG2171	N-acyltransferase activity
B1781_RS07920	COG0436	Aminotransferase
B1781_RS07935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1781_RS07940	COG0384	phenazine biosynthesis protein PhzF
B1781_RS07955	COG0454	-acetyltransferase
B1781_RS07965	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B1781_RS07970	COG0024	Methionine aminopeptidase
B1781_RS07975	COG0052	Belongs to the universal ribosomal protein uS2 family
B1781_RS07980	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B1781_RS07985	COG0528	UMP kinase activity
B1781_RS07990	COG0233	cytoplasmic translational termination
B1781_RS07995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B1781_RS08000	COG0575	Belongs to the CDS family
B1781_RS08005	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B1781_RS08025	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1781_RS08030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B1781_RS08035	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1781_RS08040	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1781_RS08050	COG0587	DNA-directed DNA polymerase activity
B1781_RS08055	COG0825	malonyl-CoA metabolic process
B1781_RS08060	COG0037	tRNA processing
B1781_RS08065	COG2995	paraquat-inducible protein a
B1781_RS08075	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B1781_RS08080	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B1781_RS08085	COG0574	Belongs to the PEP-utilizing enzyme family
B1781_RS08085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1781_RS08090	COG3005	denitrification pathway
B1781_RS08100	COG0367	asparagine synthase
B1781_RS08105	COG0438	transferase activity, transferring glycosyl groups
B1781_RS08110	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B1781_RS08115	COG0354	folic acid binding
B1781_RS08120	COG0557	exoribonuclease II activity
B1781_RS08175	COG3128	pkhd-type hydroxylase
B1781_RS08180	COG4774	siderophore transport
B1781_RS08195	COG0848	biopolymer transport protein
B1781_RS08200	COG0811	peptide transport
B1781_RS08225	COG0500	methyltransferase
B1781_RS08230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B1781_RS08245	COG5398	heme oxygenase
B1781_RS08250	COG4251	negative regulation of phosphorylation
B1781_RS08255	COG3258	Cytochrome c
B1781_RS08270	COG0753	catalase activity
B1781_RS08280	COG0745	RESPONSE REGULATOR receiver
B1781_RS08285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1781_RS08305	COG4953	penicillin-binding protein 1C
B1781_RS08310	COG2373	Large extracellular alpha-helical protein
B1781_RS08330	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B1781_RS08335	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
B1781_RS08340	COG3454	Phosphonate metabolism
B1781_RS08345	COG4778	phosphonate C-P lyase system protein PhnL
B1781_RS08350	COG4107	phosphonate C-P lyase system protein PhnK
B1781_RS08355	COG3627	carbon phosphorus lyase activity
B1781_RS08360	COG3626	phosphonate metabolism
B1781_RS08365	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
B1781_RS08370	COG3624	Phosphonate C-P lyase system protein PhnG
B1781_RS08380	COG3454	Phosphonate metabolism
B1781_RS08385	COG3639	organic phosphonate transmembrane transporter activity
B1781_RS08390	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
B1781_RS08410	COG0121	glutamine amidotransferase
B1781_RS08415	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B1781_RS08420	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B1781_RS08430	COG0840	transmembrane signaling receptor activity
B1781_RS08435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B1781_RS08440	COG1127	ABC transporter
B1781_RS08470	COG0653	protein targeting
B1781_RS08485	COG1690	Belongs to the RtcB family
B1781_RS08505	COG0583	DNA-binding transcription factor activity
B1781_RS08515	COG1858	cytochrome C peroxidase
B1781_RS08530	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B1781_RS08550	COG4191	Histidine kinase
B1781_RS08555	COG2204	response regulator
B1781_RS08565	COG0375	protein maturation
B1781_RS08570	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
B1781_RS08585	COG1773	rubredoxin
B1781_RS08610	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
B1781_RS08635	COG2046	Belongs to the sulfate adenylyltransferase family
B1781_RS08635	COG0529	Catalyzes the synthesis of activated sulfate
B1781_RS08660	COG1959	2 iron, 2 sulfur cluster binding
B1781_RS08665	COG1104	cysteine desulfurase activity
B1781_RS08670	COG0724	RNA recognition motif
B1781_RS08675	COG0822	iron-sulfur transferase activity
B1781_RS08685	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B1781_RS08710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B1781_RS08715	COG0105	UTP biosynthetic process
B1781_RS08720	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B1781_RS08735	COG0124	histidyl-tRNA synthetase
B1781_RS08740	COG2976	Protein conserved in bacteria
B1781_RS08745	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1781_RS08750	COG1160	GTP binding
B1781_RS08755	COG1570	exodeoxyribonuclease VII activity
B1781_RS08770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B1781_RS08770	COG0519	Catalyzes the synthesis of GMP from XMP
B1781_RS08790	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B1781_RS08795	COG1643	Atp-dependent helicase
B1781_RS08800	COG0745	RESPONSE REGULATOR receiver
B1781_RS08815	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B1781_RS08820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B1781_RS08835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1781_RS08840	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B1781_RS08845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B1781_RS08850	COG2974	May be involved in recombination
B1781_RS08860	COG0625	glutathione transferase activity
B1781_RS08880	COG0525	valine-tRNA ligase activity
B1781_RS08885	COG0840	transmembrane signaling receptor activity
B1781_RS08905	COG0617	tRNA 3'-terminal CCA addition
B1781_RS08930	COG2198	Histidine kinase
B1781_RS08930	COG5002	protein histidine kinase activity
B1781_RS08930	COG0784	Response regulator, receiver
B1781_RS08940	COG4206	TonB-dependent receptor
B1781_RS08945	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B1781_RS08950	COG0166	Belongs to the GPI family
B1781_RS08965	COG0436	Aminotransferase
B1781_RS08970	COG0556	nucleotide-excision repair
B1781_RS08975	COG0583	DNA-binding transcription factor activity
B1781_RS08980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B1781_RS08990	COG0175	sulfate reduction
B1781_RS08995	COG0529	Catalyzes the synthesis of activated sulfate
B1781_RS09050	COG4566	intracellular signal transduction
B1781_RS09060	COG1858	cytochrome C peroxidase
B1781_RS09075	COG4941	Belongs to the sigma-70 factor family
B1781_RS09100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1781_RS09145	COG3706	GGDEF domain
B1781_RS09150	COG0647	UMP catabolic process
B1781_RS09165	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B1781_RS09165	COG0493	'glutamate synthase
B1781_RS09170	COG0649	NAD binding
B1781_RS09175	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1781_RS09180	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1781_RS09190	COG2111	Na H antiporter
B1781_RS09190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B1781_RS09195	COG0651	ATP synthesis coupled electron transport
B1781_RS09200	COG1006	Multisubunit Na H antiporter MnhC subunit
B1781_RS09225	COG1863	multisubunit Na H antiporter MnhE subunit
B1781_RS09230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1781_RS09245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B1781_RS09250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B1781_RS09255	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B1781_RS09260	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B1781_RS09265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B1781_RS09270	COG0072	phenylalanine-tRNA ligase activity
B1781_RS09275	COG0776	regulation of translation
B1781_RS09290	COG5001	Diguanylate cyclase
B1781_RS09290	COG4251	negative regulation of phosphorylation
B1781_RS09290	COG3706	GGDEF domain
B1781_RS09290	COG2203	Gaf domain
B1781_RS09305	COG0647	UMP catabolic process
B1781_RS09325	COG5001	Diguanylate cyclase
B1781_RS09325	COG5002	protein histidine kinase activity
B1781_RS09335	COG1643	Atp-dependent helicase
B1781_RS09340	COG3012	SEC-C Motif Domain Protein
B1781_RS09350	COG1196	nuclear chromosome segregation
B1781_RS09350	COG0741	lytic transglycosylase activity
B1781_RS09350	COG0739	heme binding
B1781_RS09355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1781_RS09380	COG0429	hydrolase of the alpha beta-hydrolase fold
B1781_RS09385	COG1132	(ABC) transporter
B1781_RS09395	COG1538	Outer membrane efflux protein
B1781_RS09400	COG1216	Glycosyl transferase, family 2
B1781_RS09435	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B1781_RS09450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1781_RS09465	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B1781_RS09475	COG0066	3-isopropylmalate dehydratase activity
B1781_RS09480	COG0473	3-isopropylmalate dehydrogenase activity
B1781_RS09495	COG0101	tRNA pseudouridine synthase activity
B1781_RS09500	COG0135	phosphoribosylanthranilate isomerase activity
B1781_RS09505	COG0133	tryptophan synthase activity
B1781_RS09510	COG0159	tryptophan synthase activity
B1781_RS09515	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B1781_RS09520	COG0285	dihydrofolate synthase activity
B1781_RS09530	COG1286	toxin biosynthetic process
B1781_RS09560	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
B1781_RS09570	COG2211	Major facilitator Superfamily
B1781_RS09655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1781_RS09660	COG0583	DNA-binding transcription factor activity
B1781_RS09670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1781_RS09780	COG0530	calcium, potassium:sodium antiporter activity
B1781_RS09795	COG3746	phosphate-selective porin O and P
B1781_RS09800	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
B1781_RS09855	COG0826	peptidase U32
B1781_RS09870	COG0497	DNA recombination
B1781_RS09875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B1781_RS09880	COG1420	regulation of RNA biosynthetic process
B1781_RS09890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B1781_RS09895	COG0443	Heat shock 70 kDa protein
B1781_RS09900	COG0484	heat shock protein binding
B1781_RS09915	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B1781_RS09925	COG1970	mechanosensitive ion channel activity
B1781_RS09935	COG1028	Short-chain dehydrogenase reductase Sdr
B1781_RS09950	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B1781_RS09955	COG0284	orotidine-5'-phosphate decarboxylase activity
B1781_RS09960	COG2046	Belongs to the sulfate adenylyltransferase family
B1781_RS09965	COG0494	nUDIX hydrolase
B1781_RS10010	COG1450	Type ii and iii secretion system protein
B1781_RS10035	COG4795	General secretion pathway protein
B1781_RS10050	COG2165	general secretion pathway protein
B1781_RS10055	COG1459	type II secretion system
B1781_RS10060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B1781_RS10090	COG2815	serine threonine protein kinase
B1781_RS10090	COG0515	serine threonine protein kinase
B1781_RS10100	COG0489	protein tyrosine kinase activity
B1781_RS10140	COG0438	transferase activity, transferring glycosyl groups
B1781_RS10155	COG0463	Glycosyl transferase, family 2
B1781_RS10160	COG0438	transferase activity, transferring glycosyl groups
B1781_RS10170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B1781_RS10185	COG3153	acetyltransferase
B1781_RS10185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1781_RS10200	COG2850	peptidyl-arginine hydroxylation
B1781_RS10225	COG2915	High frequency lysogenization protein hflD homolog
B1781_RS10230	COG0482	sulfurtransferase activity
B1781_RS10245	COG1187	pseudouridine synthase activity
B1781_RS10255	COG1278	Cold shock
B1781_RS10260	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B1781_RS10265	COG0542	response to heat
B1781_RS10270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B1781_RS10275	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B1781_RS10280	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B1781_RS10295	COG0492	ferredoxin-NADP+ reductase activity
B1781_RS10300	COG0686	Belongs to the AlaDH PNT family
B1781_RS10310	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B1781_RS10335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1781_RS10340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B1781_RS10345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B1781_RS10355	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B1781_RS10370	COG0670	Belongs to the BI1 family
B1781_RS10385	COG1573	uracil-dna glycosylase
B1781_RS10390	COG0322	excinuclease ABC activity
B1781_RS10405	COG0582	viral genome integration into host DNA
B1781_RS10485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1781_RS10490	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B1781_RS10495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1781_RS10500	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
B1781_RS10515	COG0489	protein tyrosine kinase activity
B1781_RS10545	COG0367	asparagine synthase
B1781_RS10550	COG0424	maF-like protein
B1781_RS10555	COG3630	sodium ion export across plasma membrane
B1781_RS10560	COG0511	ligase activity, forming carbon-carbon bonds
B1781_RS10560	COG5016	pyruvate
B1781_RS10565	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
B1781_RS10570	COG1399	metal-binding, possibly nucleic acid-binding protein
B1781_RS10575	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B1781_RS10580	COG0416	fatty acid biosynthetic process
B1781_RS10585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1781_RS10590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B1781_RS10600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1781_RS10605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1781_RS10610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1781_RS10615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B1781_RS10620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B1781_RS10635	COG0084	hydrolase, TatD family'
B1781_RS10645	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B1781_RS10660	COG3026	antisigma factor binding
B1781_RS10670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1781_RS10680	COG0481	GTPase activity
B1781_RS10695	COG0571	ribonuclease III activity
B1781_RS10705	COG1381	Involved in DNA repair and RecF pathway recombination
B1781_RS10710	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B1781_RS10715	COG2205	protein histidine kinase activity
B1781_RS10715	COG0784	Response regulator, receiver
B1781_RS10715	COG5002	protein histidine kinase activity
B1781_RS10735	COG2954	triphosphatase activity
B1781_RS10750	COG0601	transmembrane transport
B1781_RS10755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1781_RS10765	COG1472	Belongs to the glycosyl hydrolase 3 family
B1781_RS10805	COG0668	transmembrane transport
B1781_RS10810	COG4771	TonB-dependent receptor
B1781_RS10815	COG3720	iron ion transport
B1781_RS10835	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B1781_RS10895	COG1230	cation diffusion facilitator family transporter
B1781_RS10945	COG0628	permease
B1781_RS10950	COG5487	UPF0391 membrane protein
B1781_RS10955	COG1597	lipid kinase activity
B1781_RS10965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1781_RS10980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B1781_RS10985	COG3383	formate dehydrogenase (NAD+) activity
B1781_RS10995	COG1999	signal sequence binding
B1781_RS11000	COG3391	amine dehydrogenase activity
B1781_RS11005	COG1858	cytochrome C peroxidase
B1781_RS11010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1781_RS11020	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
B1781_RS11030	COG0702	epimerase
B1781_RS11040	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
B1781_RS11045	COG4067	protein conserved in archaea
B1781_RS11045	COG0189	ligase activity
B1781_RS11055	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
B1781_RS11065	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B1781_RS11105	COG1229	Formylmethanofuran dehydrogenase subunit A
B1781_RS11130	COG3284	Transcriptional regulator
B1781_RS11135	COG0671	phosphoesterase, PA-phosphatase related
B1781_RS11145	COG1283	sodium-dependent phosphate transmembrane transporter activity
B1781_RS11160	COG1752	Esterase of the alpha-beta hydrolase superfamily
B1781_RS11185	COG1595	DNA-templated transcription, initiation
B1781_RS11210	COG5002	protein histidine kinase activity
B1781_RS11220	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B1781_RS11245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B1781_RS11260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B1781_RS11285	COG1335	isochorismatase
B1781_RS11305	COG0450	alkyl hydroperoxide reductase
B1781_RS11310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1781_RS11315	COG1201	RNA secondary structure unwinding
B1781_RS11325	COG1793	dna ligase
B1781_RS11330	COG1280	lysine exporter protein (LysE YggA)
B1781_RS11360	COG1121	(ABC) transporter
B1781_RS11365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B1781_RS11380	COG2154	pterin-4-alpha-carbinolamine dehydratase
B1781_RS11390	COG0681	Belongs to the peptidase S26 family
B1781_RS11440	COG1032	radical SAM domain protein
B1781_RS11445	COG1032	radical SAM domain protein
B1781_RS11485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B1781_RS11495	COG1231	oxidoreductase activity
B1781_RS11520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B1781_RS11525	COG3391	amine dehydrogenase activity
B1781_RS11530	COG1999	signal sequence binding
B1781_RS11535	COG4191	Histidine kinase
B1781_RS11540	COG4566	intracellular signal transduction
B1781_RS11575	COG4191	Histidine kinase
B1781_RS11580	COG4566	intracellular signal transduction
B1781_RS11585	COG3239	Fatty acid desaturase
B1781_RS11635	COG0471	metal ion transport
B1781_RS11665	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
B1781_RS11675	COG1196	nuclear chromosome segregation
B1781_RS11680	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B1781_RS11705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B1781_RS11725	COG2116	formate transmembrane transporter activity
B1781_RS11735	COG2202	Pas domain
B1781_RS11735	COG3920	Histidine kinase
B1781_RS11760	COG2304	oxidoreductase activity
B1781_RS11780	COG0714	Associated with various cellular activities
B1781_RS11805	COG3046	protein related to deoxyribodipyrimidine photolyase
B1781_RS11815	COG1309	transcriptional regulator
B1781_RS11820	COG0425	Belongs to the sulfur carrier protein TusA family
B1781_RS11825	COG2210	Belongs to the sulfur carrier protein TusA family
B1781_RS11850	COG1960	acyl-CoA dehydrogenase activity
B1781_RS11855	COG0183	Belongs to the thiolase family
B1781_RS11865	COG1022	Amp-dependent synthetase and ligase
B1781_RS11880	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B1781_RS11920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1781_RS11930	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B1781_RS11940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B1781_RS11945	COG1053	succinate dehydrogenase
B1781_RS11950	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B1781_RS11960	COG3028	Belongs to the UPF0307 family
B1781_RS11965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B1781_RS11975	COG1968	undecaprenyl-diphosphatase activity
B1781_RS11985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1781_RS12025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1781_RS12030	COG0367	asparagine synthase
B1781_RS12060	COG0616	signal peptide processing
B1781_RS12065	COG0546	phosphoglycolate phosphatase activity
B1781_RS12075	COG1530	ribonuclease E activity
B1781_RS12080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B1781_RS12090	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B1781_RS12095	COG2835	tetraacyldisaccharide 4'-kinase activity
B1781_RS12095	COG1663	tetraacyldisaccharide 4'-kinase activity
B1781_RS12100	COG1663	tetraacyldisaccharide 4'-kinase activity
B1781_RS12105	COG0848	biopolymer transport protein
B1781_RS12110	COG0811	peptide transport
B1781_RS12115	COG0658	competence protein
B1781_RS12115	COG2333	competence protein COMEC
B1781_RS12125	COG1136	(ABC) transporter
B1781_RS12130	COG4591	ABC-type transport system involved in lipoprotein release permease component
B1781_RS12140	COG2957	Belongs to the agmatine deiminase family
B1781_RS12145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1781_RS12150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1781_RS12205	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B1781_RS12220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B1781_RS12220	COG2755	lipolytic protein G-D-S-L family
B1781_RS12235	COG3240	lipase activity
B1781_RS12275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1781_RS12305	COG1595	DNA-templated transcription, initiation
B1781_RS12355	COG1595	DNA-templated transcription, initiation
B1781_RS12380	COG1132	(ABC) transporter
B1781_RS12410	COG4654	Cytochrome c, class I
B1781_RS12415	COG0437	4 iron, 4 sulfur cluster binding
B1781_RS12420	COG0243	molybdopterin cofactor binding
B1781_RS12445	COG4191	Histidine kinase
B1781_RS12450	COG2204	response regulator
B1781_RS12490	COG0530	calcium, potassium:sodium antiporter activity
B1781_RS12505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B1781_RS12515	COG0457	Tetratricopeptide repeat
B1781_RS12520	COG1649	PFAM Uncharacterised BCR, COG1649
B1781_RS12520	COG0726	polysaccharide deacetylase
B1781_RS12525	COG1215	transferase activity, transferring glycosyl groups
B1781_RS12535	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
B1781_RS12565	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B1781_RS12600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1781_RS12600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B1781_RS12610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1781_RS12630	COG0456	acetyltransferase
B1781_RS12635	COG0303	'Molybdopterin
B1781_RS12645	COG3842	ATPase activity
B1781_RS12650	COG4662	Binding-protein-dependent transport system inner membrane component
B1781_RS12660	COG2204	response regulator
B1781_RS12670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B1781_RS12680	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B1781_RS12685	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B1781_RS12715	COG0243	molybdopterin cofactor binding
B1781_RS12715	COG3383	formate dehydrogenase (NAD+) activity
B1781_RS12720	COG0437	4 iron, 4 sulfur cluster binding
B1781_RS12735	COG0247	lactate metabolic process
B1781_RS12735	COG2181	nitrate reductase activity
B1781_RS12760	COG0583	DNA-binding transcription factor activity
B1781_RS12765	COG1028	Short-chain dehydrogenase reductase Sdr
B1781_RS12785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B1781_RS12815	COG0741	lytic transglycosylase activity
B1781_RS12835	COG2358	TRAP transporter, solute receptor (TAXI family
B1781_RS12840	COG0735	belongs to the Fur family
B1781_RS12845	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1781_RS12850	COG2914	Belongs to the UPF0125 (RnfH) family
B1781_RS12860	COG0733	neurotransmitter:sodium symporter activity
B1781_RS12870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B1781_RS12885	COG0297	glycogen (starch) synthase activity
B1781_RS12890	COG1216	Glycosyl transferase, family 2
B1781_RS12890	COG0463	Glycosyl transferase, family 2
B1781_RS12895	COG0438	transferase activity, transferring glycosyl groups
B1781_RS12905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1781_RS12910	COG1960	acyl-CoA dehydrogenase activity
B1781_RS12925	COG0457	Tetratricopeptide repeat
B1781_RS12930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1781_RS12955	COG2423	ornithine cyclodeaminase activity
B1781_RS12975	COG0840	transmembrane signaling receptor activity
B1781_RS12980	COG0617	tRNA 3'-terminal CCA addition
B1781_RS12985	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1781_RS13010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B1781_RS13035	COG2119	membrane
B1781_RS13040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B1781_RS13045	COG0640	Transcriptional regulator
B1781_RS13060	COG0071	Belongs to the small heat shock protein (HSP20) family
B1781_RS13065	COG1611	Belongs to the LOG family
B1781_RS13070	COG2202	Pas domain
B1781_RS13070	COG2205	protein histidine kinase activity
B1781_RS13085	COG1842	Phage shock protein A
B1781_RS13095	COG5002	protein histidine kinase activity
B1781_RS13105	COG1902	pentaerythritol trinitrate reductase activity
B1781_RS13210	COG2226	methyltransferase
B1781_RS13220	COG2166	iron-sulfur cluster assembly
B1781_RS13225	COG0316	Belongs to the HesB IscA family
B1781_RS13235	COG0719	Fe-S assembly protein
B1781_RS13240	COG0396	ATPase activity
B1781_RS13245	COG0719	Fe-S assembly protein
B1781_RS13255	COG0577	efflux transmembrane transporter activity
B1781_RS13270	COG1858	cytochrome C peroxidase
B1781_RS13275	COG5001	Diguanylate cyclase
B1781_RS13275	COG4251	negative regulation of phosphorylation
B1781_RS13275	COG3706	GGDEF domain
B1781_RS13275	COG2203	Gaf domain
B1781_RS13290	COG1216	Glycosyl transferase, family 2
B1781_RS13290	COG0463	Glycosyl transferase, family 2
B1781_RS13310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1781_RS13315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1781_RS13345	COG0514	ATP-dependent DNA helicase (RecQ)
B1781_RS13350	COG2226	methyltransferase
B1781_RS13355	COG0588	phosphoglycerate mutase activity
B1781_RS13390	COG2207	Transcriptional regulator
B1781_RS13405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1781_RS13410	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B1781_RS13425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B1781_RS13435	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B1781_RS13440	COG1802	Transcriptional regulator
B1781_RS13475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B1781_RS13480	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
B1781_RS13490	COG0281	malic enzyme
B1781_RS13500	COG3243	poly(R)-hydroxyalkanoic acid synthase
B1781_RS13510	COG0183	Belongs to the thiolase family
B1781_RS13515	COG1028	Short-chain dehydrogenase reductase Sdr
B1781_RS13520	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
B1781_RS13530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1781_RS13550	COG1205	dead DEAH box helicase
B1781_RS13550	COG1111	helicase
B1781_RS13555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B1781_RS13565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1781_RS13570	COG4106	trans-aconitate 2-methyltransferase activity
B1781_RS13580	COG0726	polysaccharide deacetylase
B1781_RS13655	COG0776	regulation of translation
B1781_RS13665	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B1781_RS13670	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B1781_RS13675	COG0287	Prephenate dehydrogenase
B1781_RS13680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1781_RS13685	COG0077	Prephenate dehydratase
B1781_RS13685	COG1605	Chorismate mutase
B1781_RS13690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1781_RS13695	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B1781_RS13705	COG3258	Cytochrome c
B1781_RS13720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1781_RS13725	COG0840	transmembrane signaling receptor activity
B1781_RS13730	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B1781_RS13735	COG0402	S-adenosylhomocysteine deaminase activity
B1781_RS13745	COG0546	phosphoglycolate phosphatase activity
B1781_RS13755	COG1028	Short-chain dehydrogenase reductase Sdr
B1781_RS13795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B1781_RS13800	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B1781_RS13805	COG0180	Tryptophanyl-tRNA synthetase
B1781_RS13810	COG1994	Peptidase M50
B1781_RS13815	COG0009	L-threonylcarbamoyladenylate synthase
B1781_RS13820	COG0613	PHP domain protein
B1781_RS13830	COG2917	probably involved in intracellular septation
B1781_RS13835	COG2350	Protein conserved in bacteria
B1781_RS13840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1781_RS13860	COG1238	metal cluster binding
B1781_RS13865	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B1781_RS13870	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B1781_RS13880	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B1781_RS13890	COG0585	pseudouridine synthase activity
B1781_RS13900	COG0084	hydrolase, TatD family'
B1781_RS13905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B1781_RS13910	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B1781_RS13915	COG0148	phosphopyruvate hydratase activity
B1781_RS13920	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B1781_RS13925	COG0504	CTP synthase activity
B1781_RS13935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1781_RS13940	COG3278	Belongs to the heme-copper respiratory oxidase family
B1781_RS13955	COG2010	Cytochrome c
B1781_RS13990	COG1388	LysM domain
B1781_RS13990	COG0741	lytic transglycosylase activity
B1781_RS14000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1781_RS14005	COG0601	transmembrane transport
B1781_RS14020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1781_RS14040	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B1781_RS14045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B1781_RS14050	COG0740	serine-type endopeptidase activity
B1781_RS14055	COG0544	peptidyl-prolyl cis-trans isomerase activity
B1781_RS14065	COG0318	PFAM AMP-dependent synthetase and ligase
B1781_RS14085	COG3852	Histidine kinase
B1781_RS14090	COG0822	iron-sulfur transferase activity
B1781_RS14095	COG1959	2 iron, 2 sulfur cluster binding
B1781_RS14100	COG3151	Protein conserved in bacteria
B1781_RS14105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1781_RS14110	COG0563	adenylate kinase activity
B1781_RS14115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1781_RS14120	COG0179	Fumarylacetoacetate (FAA) hydrolase
B1781_RS14125	COG0326	Molecular chaperone. Has ATPase activity
B1781_RS14130	COG0033	Phosphoglucomutase
B1781_RS14140	COG0668	transmembrane transport
B1781_RS14145	COG0598	Magnesium transport protein CorA
B1781_RS14150	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B1781_RS14155	COG0277	FAD linked oxidase domain protein
B1781_RS14160	COG0277	FAD linked oxidase domain protein
B1781_RS14255	COG1346	cytolysis
B1781_RS14270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1781_RS14290	COG1056	cytidyltransferase-related domain
B1781_RS14290	COG1051	belongs to the nudix hydrolase family
B1781_RS14295	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
B1781_RS14300	COG4302	ethanolamine ammonia-lyase activity
B1781_RS14305	COG4303	Ethanolamine ammonia lyase large subunit
B1781_RS14310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1781_RS14335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B1781_RS14340	COG2218	PFAM glutamate synthase alpha subunit domain protein
B1781_RS14345	COG0069	glutamate synthase activity
B1781_RS14355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B1781_RS14360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1781_RS14370	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1781_RS14370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1781_RS14385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1781_RS14420	COG1024	Enoyl-CoA hydratase
B1781_RS14445	COG0004	ammonium transporteR
B1781_RS14455	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1781_RS14460	COG3850	Histidine kinase
B1781_RS14465	COG2197	response regulator
B1781_RS14500	COG2818	Glycosylase
B1781_RS14515	COG4566	intracellular signal transduction
B1781_RS14520	COG4191	Histidine kinase
B1781_RS14540	COG1216	Glycosyl transferase, family 2
B1781_RS14545	COG5039	Polysaccharide pyruvyl transferase
B1781_RS14560	COG0795	lipopolysaccharide-transporting ATPase activity
B1781_RS14565	COG0795	lipopolysaccharide-transporting ATPase activity
B1781_RS14570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B1781_RS14590	COG0598	Magnesium transport protein CorA
B1781_RS14595	COG1185	polyribonucleotide nucleotidyltransferase activity
B1781_RS14600	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B1781_RS14605	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B1781_RS14610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B1781_RS14615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B1781_RS14620	COG0195	Participates in both transcription termination and antitermination
B1781_RS14625	COG0779	Required for maturation of 30S ribosomal subunits
B1781_RS14645	COG2863	cytochrome
B1781_RS14650	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1781_RS14655	COG4122	O-methyltransferase activity
B1781_RS14680	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B1781_RS14695	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
B1781_RS14725	COG0298	carbon dioxide binding
B1781_RS14730	COG0375	protein maturation
B1781_RS14740	COG0409	Hydrogenase expression formation protein
B1781_RS14745	COG0521	Mo-molybdopterin cofactor biosynthetic process
B1781_RS14750	COG0038	chloride channel
B1781_RS14760	COG2358	TRAP transporter, solute receptor (TAXI family
B1781_RS14775	COG2902	Dehydrogenase
B1781_RS14825	COG2304	oxidoreductase activity
B1781_RS14875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B1781_RS14880	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B1781_RS14885	COG3852	Histidine kinase
B1781_RS14890	COG2204	response regulator
B1781_RS14895	COG2205	protein histidine kinase activity
B1781_RS14895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1781_RS14900	COG2920	part of a sulfur-relay system
B1781_RS14910	COG3237	CsbD-like
B1781_RS14960	COG3152	Membrane
B1781_RS14985	COG0714	Associated with various cellular activities
B1781_RS15100	COG2255	four-way junction helicase activity
B1781_RS15115	COG1842	Phage shock protein A
B1781_RS15230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1781_RS15245	COG2202	Pas domain
B1781_RS15245	COG2205	protein histidine kinase activity
B1781_RS15270	COG0398	Pfam SNARE associated Golgi protein
B1781_RS15280	COG4572	Cation transport regulator
B1781_RS15300	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B1781_RS15300	COG0617	tRNA 3'-terminal CCA addition
B1781_RS15300	COG0517	IMP dehydrogenase activity
B1781_RS15315	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B1781_RS15320	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B1781_RS15325	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B1781_RS15330	COG1805	sodium ion transport
B1781_RS15370	COG0546	phosphoglycolate phosphatase activity
B1781_RS15395	COG1252	NADH dehydrogenase
B1781_RS15450	COG3284	Transcriptional regulator
B1781_RS15470	COG1116	anion transmembrane transporter activity
B1781_RS15485	COG0439	Biotin carboxylase
B1781_RS15500	COG1007	ATP synthesis coupled electron transport
B1781_RS15515	COG0713	ATP synthesis coupled electron transport
B1781_RS15525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1781_RS15530	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B1781_RS15535	COG1034	ATP synthesis coupled electron transport
B1781_RS15545	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B1781_RS15550	COG0649	NAD binding
B1781_RS15555	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1781_RS15560	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1781_RS15565	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1781_RS15580	COG0149	triose-phosphate isomerase activity
B1781_RS15585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1781_RS15590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B1781_RS15595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1781_RS15600	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B1781_RS15605	COG1534	Rna-binding protein
B1781_RS15610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B1781_RS15615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B1781_RS15620	COG0505	Belongs to the CarA family
B1781_RS15625	COG3118	belongs to the thioredoxin family
B1781_RS15630	COG3118	belongs to the thioredoxin family
B1781_RS15640	COG1720	tRNA m6t6A37 methyltransferase activity
B1781_RS15645	COG3300	MHYT domain
B1781_RS15645	COG5001	Diguanylate cyclase
B1781_RS15685	COG1126	abc transporter atp-binding protein
B1781_RS15690	COG0765	amino acid transport
B1781_RS15695	COG4597	amino acid ABC transporter
B1781_RS15700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1781_RS15705	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1781_RS15715	COG1196	nuclear chromosome segregation
B1781_RS15720	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B1781_RS15725	COG1070	Carbohydrate kinase
B1781_RS15735	COG2204	response regulator
B1781_RS15740	COG2205	protein histidine kinase activity
B1781_RS15745	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B1781_RS15750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B1781_RS15760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B1781_RS15775	COG0436	Aminotransferase
B1781_RS15810	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
B1781_RS15815	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
B1781_RS15820	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
B1781_RS15825	COG1394	ATPase activity, coupled to movement of substances
B1781_RS15830	COG3738	Protein conserved in bacteria
B1781_RS15860	COG1317	bacterial-type flagellum organization
B1781_RS15865	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B1781_RS15895	COG4536	flavin adenine dinucleotide binding
B1781_RS15915	COG0359	binds to the 23S rRNA
B1781_RS15930	COG0360	Binds together with S18 to 16S ribosomal RNA
B1781_RS15935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1781_RS15940	COG0557	exoribonuclease II activity
B1781_RS15960	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B1781_RS15990	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B1781_RS16000	COG3842	ATPase activity
B1781_RS16010	COG1074	ATP-dependent DNA helicase activity
B1781_RS16025	COG0071	Belongs to the small heat shock protein (HSP20) family
B1781_RS16030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1781_RS16040	COG1028	Short-chain dehydrogenase reductase Sdr
B1781_RS16045	COG1741	Belongs to the pirin family
B1781_RS16050	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B1781_RS16055	COG0583	DNA-binding transcription factor activity
B1781_RS16065	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B1781_RS16100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B1781_RS16105	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B1781_RS16110	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
B1781_RS16115	COG0330	HflC and HflK could
B1781_RS16120	COG0330	HflC and HflK could
B1781_RS16125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B1781_RS16130	COG1923	regulation of RNA biosynthetic process
B1781_RS16135	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B1781_RS16140	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B1781_RS16150	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1781_RS16155	COG0802	atpase or kinase
B1781_RS16160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B1781_RS16160	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B1781_RS16190	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B1781_RS16195	COG0501	Belongs to the peptidase M48B family
B1781_RS16205	COG1162	GTPase activity
B1781_RS16230	COG0215	cysteine-tRNA ligase activity
B1781_RS16270	COG2833	Protein of unknown function (DUF455)
B1781_RS16275	COG2379	hydroxypyruvate reductase
B1781_RS16290	COG0523	cobalamin synthesis protein
B1781_RS16335	COG0335	large ribosomal subunit rRNA binding
B1781_RS16340	COG0336	Belongs to the RNA methyltransferase TrmD family
B1781_RS16345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B1781_RS16350	COG0228	four-way junction DNA binding
B1781_RS16365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B1781_RS16385	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B1781_RS16395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B1781_RS16400	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
B1781_RS16405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B1781_RS16440	COG1215	transferase activity, transferring glycosyl groups
B1781_RS16445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1781_RS16450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B1781_RS16455	COG1011	Hydrolase
B1781_RS16460	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B1781_RS16465	COG2089	acid synthase
B1781_RS16475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B1781_RS16480	COG1086	Polysaccharide biosynthesis protein
B1781_RS16510	COG3047	cAMP biosynthetic process
B1781_RS16510	COG2885	chlorophyll binding
B1781_RS16515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B1781_RS16525	COG3951	Flagellar rod assembly protein muramidase FlgJ
B1781_RS16525	COG1705	Flagellar rod assembly protein muramidase FlgJ
B1781_RS16540	COG4786	Flagellar basal body rod
B1781_RS16545	COG4787	bacterial-type flagellum-dependent cell motility
B1781_RS16550	COG1749	Flagellar hook protein flgE
B1781_RS16555	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B1781_RS16560	COG1558	bacterial-type flagellum-dependent cell motility
B1781_RS16565	COG1815	bacterial-type flagellum-dependent cell motility
B1781_RS16570	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B1781_RS16575	COG0784	Response regulator, receiver
B1781_RS16575	COG0835	chemotaxis
B1781_RS16630	COG2207	Transcriptional regulator
B1781_RS16660	COG0567	Dehydrogenase, E1 component
B1781_RS16690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B1781_RS16710	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B1781_RS16715	COG0456	acetyltransferase
B1781_RS16720	COG1573	uracil-dna glycosylase
B1781_RS16725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1781_RS16730	COG1183	phosphatidylcholine synthase activity
B1781_RS16735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B1781_RS16740	COG0440	acetolactate synthase activity
B1781_RS16745	COG0028	Belongs to the TPP enzyme family
B1781_RS16755	COG1322	Protein conserved in bacteria
B1781_RS16760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1781_RS16765	COG0708	Exodeoxyribonuclease III
B1781_RS16780	COG0704	Plays a role in the regulation of phosphate uptake
B1781_RS16785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B1781_RS16790	COG0581	inorganic phosphate transmembrane transporter activity
B1781_RS16795	COG0573	inorganic phosphate transmembrane transporter activity
B1781_RS16810	COG5001	Diguanylate cyclase
B1781_RS16810	COG3706	GGDEF domain
B1781_RS16810	COG4251	negative regulation of phosphorylation
B1781_RS16810	COG2203	Gaf domain
B1781_RS16820	COG0442	prolyl-tRNA aminoacylation
B1781_RS16830	COG5002	protein histidine kinase activity
B1781_RS16835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B1781_RS16850	COG1592	Rubrerythrin
B1781_RS16855	COG0583	DNA-binding transcription factor activity
B1781_RS16860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B1781_RS16870	COG1254	Belongs to the acylphosphatase family
B1781_RS16890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1781_RS16900	COG1959	2 iron, 2 sulfur cluster binding
B1781_RS16900	COG1295	ribonuclease BN
B1781_RS16905	COG1393	Belongs to the ArsC family
B1781_RS16930	COG0628	permease
B1781_RS16935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B1781_RS16945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B1781_RS16950	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B1781_RS16960	COG0717	Belongs to the dCTP deaminase family
B1781_RS16975	COG1280	lysine exporter protein (LysE YggA)
B1781_RS16985	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B1781_RS16990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1781_RS17015	COG1028	Short-chain dehydrogenase reductase Sdr
B1781_RS17025	COG2010	Cytochrome c
B1781_RS17035	COG0489	protein tyrosine kinase activity
B1781_RS17045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1781_RS17045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1781_RS17065	COG0393	Putative heavy-metal-binding
B1781_RS17070	COG0393	Putative heavy-metal-binding
B1781_RS17075	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B1781_RS17080	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B1781_RS17085	COG4657	Part of a membrane complex involved in electron transport
B1781_RS17090	COG2878	Part of a membrane complex involved in electron transport
B1781_RS17105	COG4659	FMN binding
B1781_RS17110	COG4660	Part of a membrane complex involved in electron transport
B1781_RS17130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B1781_RS17145	COG3220	belongs to the UPF0276 family
B1781_RS17160	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B1781_RS17180	COG3038	cytochrome b561
B1781_RS17190	COG0791	NLP P60 protein
B1781_RS17205	COG3604	Transcriptional regulator
B1781_RS17210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B1781_RS17215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1781_RS17220	COG1116	anion transmembrane transporter activity
B1781_RS17225	COG0523	cobalamin synthesis protein
B1781_RS17235	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
B1781_RS17285	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B1781_RS17300	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B1781_RS17305	COG0527	aspartate kinase activity
B1781_RS17310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B1781_RS17315	COG2137	regulation of response to DNA damage stimulus
B1781_RS17325	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B1781_RS17350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B1781_RS17360	COG0631	protein serine/threonine phosphatase activity
B1781_RS17365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B1781_RS17370	COG1666	GTP binding
B1781_RS17375	COG4974	Belongs to the 'phage' integrase family
B1781_RS17380	COG3098	single-species biofilm formation
B1781_RS17385	COG2983	Belongs to the UPF0260 family
B1781_RS17400	COG0826	peptidase U32
B1781_RS17410	COG3302	dmso reductase anchor subunit
B1781_RS17415	COG0437	4 iron, 4 sulfur cluster binding
B1781_RS17420	COG0243	molybdopterin cofactor binding
B1781_RS17440	COG0561	phosphatase activity
B1781_RS17440	COG3100	YcgL domain-containing protein
B1781_RS17445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1781_RS17555	COG2391	methyltransferase activity
B1781_RS17560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B1781_RS17565	COG0602	queuosine metabolic process
B1781_RS17570	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
B1781_RS17575	COG2885	chlorophyll binding
B1781_RS17580	COG0823	Involved in the tonB-independent uptake of proteins
B1781_RS17595	COG0811	peptide transport
B1781_RS17600	COG0824	Thioesterase
B1781_RS17605	COG2255	four-way junction helicase activity
B1781_RS17625	COG0632	four-way junction helicase activity
B1781_RS17630	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B1781_RS17635	COG0217	transcriptional regulatory protein
B1781_RS17660	COG0494	nUDIX hydrolase
B1781_RS17665	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B1781_RS17690	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B1781_RS17695	COG0300	oxidoreductase activity
B1781_RS17700	COG2918	glutathione biosynthetic process
B1781_RS17710	COG0793	Belongs to the peptidase S41A family
B1781_RS17725	COG3956	TIGRFAM MazG family protein
B1781_RS17730	COG2135	peptidase activity
B1781_RS17735	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B1781_RS17745	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B1781_RS17750	COG4589	Belongs to the CDS family
B1781_RS17755	COG0204	Acyl-transferase
B1781_RS17775	COG2205	protein histidine kinase activity
B1781_RS17775	COG0784	Response regulator, receiver
B1781_RS17775	COG2198	Histidine kinase
B1781_RS17775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1781_RS17825	COG0318	PFAM AMP-dependent synthetase and ligase
B1781_RS17835	COG3485	protocatechuate 3,4-dioxygenase
B1781_RS17845	COG2239	Acts as a magnesium transporter
B1781_RS17855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1781_RS17865	COG0409	Hydrogenase expression formation protein
B1781_RS17890	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B1781_RS17925	COG0069	glutamate synthase activity
B1781_RS17930	COG0025	NhaP-type Na H and K H
B1781_RS17955	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
B1781_RS17960	COG0494	nUDIX hydrolase
B1781_RS17970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1781_RS17975	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B1781_RS18000	COG0405	Gamma-glutamyltransferase
B1781_RS18015	COG0542	response to heat
B1781_RS18030	COG0242	peptide deformylase activity
B1781_RS18040	COG1496	oxidoreductase activity
B1781_RS18045	COG0564	pseudouridine synthase activity
B1781_RS18065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B1781_RS18070	COG0045	succinate-CoA ligase (ADP-forming) activity
B1781_RS18110	COG0237	dephospho-CoA kinase activity
B1781_RS18115	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
B1781_RS18120	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B1781_RS18130	COG0352	thiamine-phosphate diphosphorylase activity
B1781_RS18135	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B1781_RS18145	COG0653	protein targeting
B1781_RS18150	COG0739	heme binding
B1781_RS18160	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B1781_RS18175	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B1781_RS18180	COG1181	Belongs to the D-alanine--D-alanine ligase family
B1781_RS18185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B1781_RS18190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B1781_RS18195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1781_RS18200	COG0772	Belongs to the SEDS family
B1781_RS18205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B1781_RS18210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1781_RS18215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B1781_RS18220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B1781_RS18230	COG3116	cell division
B1781_RS18240	COG2001	Belongs to the MraZ family
B1781_RS18255	COG3107	peptidoglycan biosynthetic process
B1781_RS18260	COG0792	nuclease activity
B1781_RS18270	COG2823	Periplasmic or secreted lipoprotein
B1781_RS18275	COG0277	FAD linked oxidase domain protein
B1781_RS18280	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B1781_RS18305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B1781_RS18310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B1781_RS18315	COG3954	Phosphoribulokinase
B1781_RS18325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B1781_RS18345	COG0671	phosphoesterase, PA-phosphatase related
B1781_RS18350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1781_RS18355	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B1781_RS18370	COG1850	ribulose-bisphosphate carboxylase activity
B1781_RS18385	COG2862	Uncharacterized protein family, UPF0114
B1781_RS18395	COG5001	Diguanylate cyclase
B1781_RS18395	COG5002	protein histidine kinase activity
B1781_RS18405	COG3710	Transcriptional regulator
B1781_RS18430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1781_RS18435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B1781_RS18450	COG0247	lactate metabolic process
B1781_RS18460	COG0741	lytic transglycosylase activity
B1781_RS18510	COG3447	MASE1 domain protein
B1781_RS18510	COG5001	Diguanylate cyclase
B1781_RS18510	COG5002	protein histidine kinase activity
B1781_RS18515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B1781_RS18520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B1781_RS18525	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B1781_RS18530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B1781_RS18535	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B1781_RS18540	COG1610	YqeY-like protein
B1781_RS18545	COG0358	DNA primase activity
B1781_RS18560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B1781_RS18585	COG1320	monovalent cation:proton antiporter activity
B1781_RS18590	COG2111	Na H antiporter
B1781_RS18590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B1781_RS18600	COG0651	ATP synthesis coupled electron transport
B1781_RS18605	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1781_RS18610	COG0651	ATP synthesis coupled electron transport
B1781_RS18615	COG0589	response to stress
B1781_RS18620	COG0583	DNA-binding transcription factor activity
B1781_RS18630	COG4251	negative regulation of phosphorylation
B1781_RS18630	COG3706	GGDEF domain
B1781_RS18630	COG2203	Gaf domain
B1781_RS18630	COG5001	Diguanylate cyclase
B1781_RS18720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B1781_RS18725	COG1331	Highly conserved protein containing a thioredoxin domain
B1781_RS18730	COG0805	protein transport
B1781_RS18735	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1781_RS18740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1781_RS18745	COG0140	phosphoribosyl-ATP diphosphatase activity
B1781_RS18750	COG0107	imidazoleglycerol-phosphate synthase activity
B1781_RS18755	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B1781_RS18760	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B1781_RS18765	COG0131	Imidazoleglycerol-phosphate dehydratase
B1781_RS18770	COG1490	D-aminoacyl-tRNA deacylase activity
B1781_RS18795	COG0596	Alpha beta hydrolase
B1781_RS18815	COG0840	transmembrane signaling receptor activity
B1781_RS18830	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B1781_RS18855	COG0191	fructose-bisphosphate aldolase activity
B1781_RS18860	COG0469	pyruvate kinase activity
B1781_RS18865	COG0126	phosphoglycerate kinase activity
B1781_RS18870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B1781_RS18875	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B1781_RS18890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B1781_RS18900	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B1781_RS18905	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B1781_RS18910	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B1781_RS18920	COG0784	Response regulator, receiver
B1781_RS18920	COG2198	Histidine kinase
B1781_RS18920	COG0643	Histidine kinase
B1781_RS18925	COG0840	transmembrane signaling receptor activity
B1781_RS18955	COG0189	ligase activity
B1781_RS18965	COG1678	Uncharacterized ACR, COG1678
B1781_RS18970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B1781_RS18975	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B1781_RS18980	COG0540	Belongs to the ATCase OTCase family
B1781_RS18990	COG0543	2 iron, 2 sulfur cluster binding
B1781_RS19020	COG1872	DUF167
B1781_RS19035	COG2211	Major facilitator Superfamily
B1781_RS19040	COG0708	Exodeoxyribonuclease III
B1781_RS19065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1781_RS19075	COG0756	dUTP diphosphatase activity
B1781_RS19080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B1781_RS19085	COG2003	Belongs to the UPF0758 family
B1781_RS19090	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B1781_RS19095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B1781_RS19105	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B1781_RS19140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1781_RS19145	COG0405	Gamma-glutamyltransferase
B1781_RS19150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B1781_RS19155	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B1781_RS19160	COG0742	ribosomal rna small subunit methyltransferase
B1781_RS19165	COG0612	Peptidase, M16
B1781_RS19170	COG0612	Peptidase, M16
B1781_RS19175	COG0552	protein localization to endoplasmic reticulum
B1781_RS19180	COG2884	Cell division ATP-binding protein ftsE
B1781_RS19185	COG2177	Part of the ABC transporter FtsEX involved in
B1781_RS19200	COG2217	Heavy metal translocating P-type atpase
B1781_RS19215	COG2010	Cytochrome c
B1781_RS19230	COG3278	Belongs to the heme-copper respiratory oxidase family
B1781_RS19235	COG0109	protoheme IX farnesyltransferase activity
B1781_RS19240	COG1612	heme a metabolic process
B1781_RS19265	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
B1781_RS19270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B1781_RS19275	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B1781_RS19285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B1781_RS19290	COG2226	methyltransferase
B1781_RS19295	COG0596	Alpha beta hydrolase
B1781_RS19300	COG0156	8-amino-7-oxononanoate synthase activity
B1781_RS19305	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B1781_RS19315	COG1040	competence protein
B1781_RS19330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B1781_RS19335	COG3161	chorismate lyase activity
B1781_RS19345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B1781_RS19350	COG3040	lipid binding
B1781_RS19360	COG0432	Pfam Uncharacterised protein family UPF0047
B1781_RS19385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B1781_RS19385	COG4797	methyltransferase
B1781_RS19420	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B1781_RS19425	COG4535	Mg2 and Co2 transporter CorC
B1781_RS19430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B1781_RS19435	COG1702	phosphate starvation-inducible protein PhoH
B1781_RS19440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1781_RS19450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1781_RS19465	COG4452	Inner membrane protein CreD
B1781_RS19470	COG2205	protein histidine kinase activity
B1781_RS19475	COG0745	RESPONSE REGULATOR receiver
B1781_RS19500	COG0395	ABC-type sugar transport system, permease component
B1781_RS19505	COG1175	transmembrane transport
B1781_RS19510	COG3842	ATPase activity
B1781_RS19515	COG3842	ATPase activity
B1781_RS19530	COG2766	serine protein kinase
B1781_RS19535	COG2718	Belongs to the UPF0229 family
B1781_RS19540	COG2719	SpoVR family
B1781_RS19555	COG0318	PFAM AMP-dependent synthetase and ligase
B1781_RS19560	COG0730	response to heat
B1781_RS19580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B1781_RS19590	COG1704	LemA family
B1781_RS19600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B1781_RS19620	COG0531	amino acid
B1781_RS19635	COG2195	Cleaves the N-terminal amino acid of tripeptides
B1781_RS19660	COG4608	Belongs to the ABC transporter superfamily
B1781_RS19665	COG0444	Belongs to the ABC transporter superfamily
B1781_RS19675	COG0601	transmembrane transport
B1781_RS19680	COG4166	transmembrane transport
B1781_RS19695	COG1067	ATP-dependent peptidase activity
B1781_RS19720	COG0303	'Molybdopterin
B1781_RS19740	COG0438	transferase activity, transferring glycosyl groups
B1781_RS19785	COG2205	protein histidine kinase activity
B1781_RS19785	COG0784	Response regulator, receiver
B1781_RS19820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1781_RS19835	COG3458	cephalosporin-C deacetylase activity
B1781_RS19845	COG5002	protein histidine kinase activity
B1781_RS19845	COG5001	Diguanylate cyclase
B1781_RS19910	COG4191	Histidine kinase
B1781_RS19915	COG0724	RNA recognition motif
B1781_RS19920	COG0513	Belongs to the DEAD box helicase family
B1781_RS19945	COG1850	ribulose-bisphosphate carboxylase activity
B1781_RS19950	COG4451	ribulose bisphosphate carboxylase, small
B1781_RS19975	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
B1781_RS19980	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
B1781_RS19995	COG0489	protein tyrosine kinase activity
B1781_RS20005	COG0583	DNA-binding transcription factor activity
B1781_RS20020	COG0494	nUDIX hydrolase
B1781_RS20025	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
B1781_RS20045	COG3002	Belongs to the UPF0753 family
B1781_RS20080	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B1781_RS20110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B1781_RS20155	COG5507	3-demethylubiquinone-9 3-methyltransferase
B1781_RS20160	COG1132	(ABC) transporter
B1781_RS20170	COG1047	Peptidyl-prolyl cis-trans
B1781_RS20205	COG1629	transport
B1781_RS20205	COG4774	siderophore transport
B1781_RS20220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B1781_RS20230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1781_RS20235	COG0519	Catalyzes the synthesis of GMP from XMP
B1781_RS20235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B1781_RS20240	COG0174	glutamine synthetase
B1781_RS20245	COG1012	belongs to the aldehyde dehydrogenase family
B1781_RS20265	COG0545	Peptidyl-prolyl cis-trans isomerase
B1781_RS20270	COG4977	sequence-specific DNA binding
B1781_RS20270	COG1917	Cupin 2, conserved barrel domain protein
B1781_RS20285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B1781_RS20300	COG2201	protein-glutamate methylesterase activity
B1781_RS20305	COG2198	Histidine kinase
B1781_RS20305	COG5002	protein histidine kinase activity
B1781_RS20305	COG0784	Response regulator, receiver
B1781_RS20310	COG1253	flavin adenine dinucleotide binding
B1781_RS20325	COG2814	Major facilitator Superfamily
B1781_RS20330	COG0745	RESPONSE REGULATOR receiver
B1781_RS20335	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B1781_RS20355	COG0203	ribosomal protein L17
B1781_RS20360	COG0202	RNA polymerase activity
B1781_RS20365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B1781_RS20370	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B1781_RS20375	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B1781_RS20380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B1781_RS20385	COG0201	protein transport
B1781_RS20390	COG0200	Binds to the 23S rRNA
B1781_RS20395	COG1841	ribosomal large subunit assembly
B1781_RS20400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B1781_RS20405	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B1781_RS20410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B1781_RS20415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B1781_RS20420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B1781_RS20425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B1781_RS20430	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B1781_RS20435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B1781_RS20440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B1781_RS20445	COG0255	Belongs to the universal ribosomal protein uL29 family
B1781_RS20450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B1781_RS20455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B1781_RS20460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B1781_RS20465	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B1781_RS20470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B1781_RS20480	COG0088	Forms part of the polypeptide exit tunnel
B1781_RS20485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B1781_RS20490	COG0051	transcription antitermination factor activity, RNA binding
B1781_RS20495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1781_RS20500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1781_RS20505	COG0049	tRNA binding
B1781_RS20510	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B1781_RS20515	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B1781_RS20520	COG0085	RNA polymerase activity
B1781_RS20525	COG0222	ribosome binding
B1781_RS20530	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B1781_RS20535	COG0081	regulation of translation
B1781_RS20540	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B1781_RS20550	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B1781_RS20560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1781_RS20595	COG2409	Drug exporters of the RND superfamily
B1781_RS20600	COG0193	aminoacyl-tRNA hydrolase activity
B1781_RS20605	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B1781_RS20610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B1781_RS20625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B1781_RS20635	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B1781_RS20640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B1781_RS20645	COG2890	protein-(glutamine-N5) methyltransferase activity
B1781_RS20660	COG3150	esterase
B1781_RS20665	COG2813	Specifically methylates the guanine in position
B1781_RS20670	COG3706	GGDEF domain
B1781_RS20680	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1781_RS20685	COG0154	amidase activity
B1781_RS20690	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1781_RS20695	COG1077	Cell shape determining protein MreB Mrl
B1781_RS20700	COG1792	Involved in formation and maintenance of cell shape
B1781_RS20705	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B1781_RS20710	COG0768	penicillin binding
B1781_RS20715	COG0772	Belongs to the SEDS family
B1781_RS20720	COG2951	lytic endotransglycosylase activity
B1781_RS20730	COG1686	Belongs to the peptidase S11 family
B1781_RS20755	COG0367	asparagine synthase
B1781_RS20760	COG1181	Belongs to the D-alanine--D-alanine ligase family
B1781_RS20765	COG1363	Peptidase, m42
B1781_RS20855	COG1280	lysine exporter protein (LysE YggA)
B1781_RS20920	COG0386	Belongs to the glutathione peroxidase family
B1781_RS20930	COG0789	Transcriptional regulator
B1781_RS20940	COG0415	Belongs to the DNA photolyase family
B1781_RS20945	COG0625	glutathione transferase activity
B1781_RS20950	COG0579	oxidoreductase
B1781_RS20970	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B1781_RS20985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1781_RS21015	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B1781_RS21025	COG3437	response regulator, receiver
B1781_RS21030	COG0784	Response regulator, receiver
B1781_RS21030	COG2205	protein histidine kinase activity
B1781_RS21035	COG0564	pseudouridine synthase activity
B1781_RS21060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B1781_RS21065	COG1444	tRNA N-acetyltransferase activity
B1781_RS21075	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B1781_RS21080	COG4181	ATPase activity
B1781_RS21100	COG5001	Diguanylate cyclase
B1781_RS21100	COG5002	protein histidine kinase activity
B1781_RS21105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B1781_RS21115	COG1410	methionine synthase
B1781_RS21115	COG0646	methionine synthase
B1781_RS21125	COG2205	protein histidine kinase activity
B1781_RS21125	COG0784	Response regulator, receiver
B1781_RS21150	COG1136	(ABC) transporter
B1781_RS21205	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B1781_RS21210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1781_RS21215	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B1781_RS21230	COG2967	ApaG domain
B1781_RS21235	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B1781_RS21245	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B1781_RS21255	COG1765	OsmC-like protein
B1781_RS21265	COG0134	indole-3-glycerol-phosphate synthase activity
B1781_RS21270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1781_RS21280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B1781_RS21295	COG0546	phosphoglycolate phosphatase activity
B1781_RS21300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B1781_RS21315	COG0018	arginyl-trna synthetase
B1781_RS21320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B1781_RS21330	COG3001	Fructosamine kinase
B1781_RS21340	COG1196	nuclear chromosome segregation
B1781_RS21340	COG3264	Mechanosensitive ion channel
B1781_RS21345	COG0189	ligase activity
B1781_RS21345	COG4067	protein conserved in archaea
B1781_RS21350	COG0189	ligase activity
B1781_RS21360	COG0004	ammonium transporteR
B1781_RS21375	COG2960	long-chain fatty acid transporting porin activity
B1781_RS21380	COG0606	chelatase, subunit chli
B1781_RS21385	COG0488	(ABC) transporter
B1781_RS21395	COG2133	pyrroloquinoline quinone binding
B1781_RS21420	COG0633	Ferredoxin
B1781_RS21420	COG3217	Mosc domain protein beta barrel domain protein
B1781_RS21430	COG1454	alcohol dehydrogenase
B1781_RS21450	COG3100	YcgL domain-containing protein
B1781_RS21455	COG0560	Phosphoserine phosphatase
B1781_RS21455	COG3830	Belongs to the UPF0237 family
B1781_RS21485	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B1781_RS21490	COG0784	Response regulator, receiver
B1781_RS21490	COG2205	protein histidine kinase activity
B1781_RS21490	COG5002	protein histidine kinase activity
B1781_RS21495	COG3604	Transcriptional regulator
B1781_RS21505	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B1781_RS21515	COG0667	Aldo Keto reductase
B1781_RS21540	COG0776	regulation of translation
B1781_RS21595	COG0714	Associated with various cellular activities
B1781_RS21615	COG2048	Heterodisulfide reductase, subunit B
B1781_RS21620	COG1301	dicarboxylic acid transport
B1781_RS21625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B1781_RS21630	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B1781_RS21680	COG2363	Small membrane protein
B1781_RS21690	COG2204	response regulator
B1781_RS21700	COG0745	RESPONSE REGULATOR receiver
B1781_RS21710	COG1166	arginine decarboxylase activity
B1781_RS21715	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B1781_RS21740	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B1781_RS21745	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B1781_RS21755	COG1396	sequence-specific DNA binding
B1781_RS21765	COG2321	neutral zinc metallopeptidase
B1781_RS21770	COG0433	COG0433 Predicted ATPase
B1781_RS21795	COG3220	belongs to the UPF0276 family
B1781_RS21805	COG1331	Highly conserved protein containing a thioredoxin domain
B1781_RS21825	COG1595	DNA-templated transcription, initiation
B1781_RS21835	COG0314	molybdopterin synthase activity
B1781_RS21840	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B1781_RS21845	COG0303	'Molybdopterin
B1781_RS21860	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B1781_RS21865	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1781_RS21870	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B1781_RS21875	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1781_RS21880	COG0509	glycine decarboxylation via glycine cleavage system
B1781_RS21885	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1781_RS21895	COG1178	ABC-type Fe3 transport system permease component
B1781_RS21905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1781_RS21910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1781_RS21915	COG0006	proline dipeptidase activity
B1781_RS21940	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B1781_RS21950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B1781_RS21955	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B1781_RS21970	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B1781_RS21975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B1781_RS21980	COG3411	Ferredoxin
B1781_RS21985	COG0247	lactate metabolic process
B1781_RS21995	COG0457	Tetratricopeptide repeat
B1781_RS22000	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B1781_RS22010	COG0069	glutamate synthase activity
B1781_RS22010	COG0067	glutamate synthase
B1781_RS22010	COG0070	glutamate synthase
B1781_RS22020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B1781_RS22025	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B1781_RS22065	COG0372	Belongs to the citrate synthase family
B1781_RS22070	COG0039	L-malate dehydrogenase activity
B1781_RS22075	COG0281	malic enzyme
B1781_RS22080	COG0254	rRNA binding
B1781_RS22100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B1781_RS22105	COG0210	DNA helicase
B1781_RS22120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B1781_RS22125	COG0830	nickel cation binding
B1781_RS22130	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
B1781_RS22135	COG0804	urea catabolic process
B1781_RS22140	COG0832	Belongs to the urease beta subunit family
B1781_RS22145	COG0831	urea catabolic process
B1781_RS22150	COG0829	nickel cation binding
B1781_RS22205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1781_RS22210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1781_RS22225	COG1355	regulation of microtubule-based process
B1781_RS22235	COG3706	GGDEF domain
B1781_RS22280	COG0490	domain, Protein
B1781_RS22280	COG0471	metal ion transport
B1781_RS22330	COG1368	sulfuric ester hydrolase activity
B1781_RS22475	COG2183	response to ionizing radiation
B1781_RS22505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1781_RS22505	COG0574	Belongs to the PEP-utilizing enzyme family
B1781_RS22540	COG1051	belongs to the nudix hydrolase family
B1781_RS22540	COG1056	cytidyltransferase-related domain
B1781_RS22545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1781_RS22550	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B1781_RS22555	COG1047	Peptidyl-prolyl cis-trans
B1781_RS22560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B1781_RS22565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B1781_RS22575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B1781_RS22580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1781_RS22585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B1781_RS22595	COG0356	it plays a direct role in the translocation of protons across the membrane
B1781_RS22605	COG1475	DNA binding
B1781_RS22610	COG1192	Involved in chromosome partitioning
B1781_RS22615	COG0357	Ribosomal RNA small subunit methyltransferase G
B1781_RS22620	COG0625	glutathione transferase activity
B1781_RS22635	COG0445	tRNA wobble uridine modification
B1781_RS22645	COG0714	Associated with various cellular activities
B1781_RS22660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B1781_RS22670	COG0706	membrane insertase activity
B1781_RS22675	COG0594	ribonuclease P activity
B1781_RS22680	COG0230	Belongs to the bacterial ribosomal protein bL34 family