locus-tag	class	description
AVL56_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AVL56_RS00020	COG0187	DNA topoisomerase II activity
AVL56_RS00045	COG2818	Glycosylase
AVL56_RS00055	COG3078	GTPase activator activity
AVL56_RS00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AVL56_RS00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AVL56_RS00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AVL56_RS00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AVL56_RS00085	COG0569	domain protein
AVL56_RS00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AVL56_RS00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AVL56_RS00110	COG0758	DNA mediated transformation
AVL56_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
AVL56_RS00130	COG0408	coproporphyrinogen oxidase activity
AVL56_RS00135	COG3047	cAMP biosynthetic process
AVL56_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AVL56_RS00200	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AVL56_RS00220	COG2234	aminopeptidase activity
AVL56_RS00235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AVL56_RS00260	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVL56_RS00300	COG3642	lipopolysaccharide core region biosynthetic process
AVL56_RS00305	COG0859	PFAM glycosyl transferase family 9
AVL56_RS00325	COG0156	8-amino-7-oxononanoate synthase activity
AVL56_RS00335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVL56_RS00340	COG0705	Rhomboid family
AVL56_RS00350	COG3161	chorismate lyase activity
AVL56_RS00355	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AVL56_RS00365	COG0210	DNA helicase
AVL56_RS00390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AVL56_RS00430	COG0582	viral genome integration into host DNA
AVL56_RS00435	COG1757	Na H antiporter
AVL56_RS00460	COG1620	l-lactate permease
AVL56_RS00475	COG0247	lactate metabolic process
AVL56_RS00475	COG2181	nitrate reductase activity
AVL56_RS00480	COG1902	pentaerythritol trinitrate reductase activity
AVL56_RS00480	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVL56_RS00500	COG4638	Rieske (2fe-2S)
AVL56_RS00515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AVL56_RS00555	COG1760	l-serine dehydratase
AVL56_RS00560	COG0583	DNA-binding transcription factor activity
AVL56_RS00575	COG1012	belongs to the aldehyde dehydrogenase family
AVL56_RS00580	COG4948	Mandelate Racemase Muconate Lactonizing
AVL56_RS00590	COG1012	belongs to the aldehyde dehydrogenase family
AVL56_RS00595	COG4771	TonB-dependent receptor
AVL56_RS00600	COG0457	Tetratricopeptide repeat
AVL56_RS00605	COG4999	Histidine kinase
AVL56_RS00605	COG3850	Histidine kinase
AVL56_RS00605	COG3437	response regulator, receiver
AVL56_RS00605	COG2205	protein histidine kinase activity
AVL56_RS00610	COG4773	Receptor
AVL56_RS00615	COG0583	DNA-binding transcription factor activity
AVL56_RS00630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVL56_RS00635	COG1129	ABC transporter
AVL56_RS00635	COG0842	Transport permease protein
AVL56_RS00640	COG0842	Transport permease protein
AVL56_RS00650	COG1960	acyl-CoA dehydrogenase activity
AVL56_RS00655	COG0583	DNA-binding transcription factor activity
AVL56_RS00670	COG3106	COG3106 Predicted ATPase
AVL56_RS00690	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AVL56_RS00705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AVL56_RS00720	COG4771	TonB-dependent receptor
AVL56_RS00725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL56_RS00735	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AVL56_RS00735	COG0778	Nitroreductase
AVL56_RS00745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AVL56_RS00750	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AVL56_RS00755	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AVL56_RS00760	COG1309	transcriptional regulator
AVL56_RS00785	COG1953	Uracil, thiamine, allantoin
AVL56_RS00795	COG3071	HemY protein
AVL56_RS00800	COG2959	enzyme of heme biosynthesis
AVL56_RS00810	COG0181	hydroxymethylbilane synthase activity
AVL56_RS00825	COG0194	GDP metabolic process
AVL56_RS00835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AVL56_RS00845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVL56_RS00850	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AVL56_RS00860	COG0678	peroxiredoxin activity
AVL56_RS00860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AVL56_RS00880	COG1178	ABC-type Fe3 transport system permease component
AVL56_RS00885	COG3842	ATPase activity
AVL56_RS00890	COG3300	MHYT domain
AVL56_RS00890	COG5001	Diguanylate cyclase
AVL56_RS00900	COG2081	HI0933 family
AVL56_RS00905	COG0668	transmembrane transport
AVL56_RS00930	COG3447	MASE1 domain protein
AVL56_RS00930	COG5001	Diguanylate cyclase
AVL56_RS00930	COG5002	protein histidine kinase activity
AVL56_RS00940	COG0583	DNA-binding transcription factor activity
AVL56_RS00965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVL56_RS00970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVL56_RS00980	COG0427	acetyl-CoA hydrolase
AVL56_RS00985	COG0123	including yeast histone deacetylase and acetoin utilization protein
AVL56_RS00995	COG0840	transmembrane signaling receptor activity
AVL56_RS01005	COG3064	Membrane
AVL56_RS01010	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVL56_RS01015	COG5001	Diguanylate cyclase
AVL56_RS01015	COG5002	protein histidine kinase activity
AVL56_RS01025	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AVL56_RS01035	COG0514	ATP-dependent DNA helicase (RecQ)
AVL56_RS01040	COG2050	protein possibly involved in aromatic compounds catabolism
AVL56_RS01045	COG2239	Acts as a magnesium transporter
AVL56_RS01050	COG2962	Rard protein
AVL56_RS01070	COG1011	Hydrolase
AVL56_RS01085	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AVL56_RS01090	COG0019	diaminopimelate decarboxylase activity
AVL56_RS01120	COG0163	prenyltransferase activity
AVL56_RS01125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AVL56_RS01135	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AVL56_RS01160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AVL56_RS01165	COG2814	Major facilitator Superfamily
AVL56_RS01170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVL56_RS01190	COG1085	galactose-1-phosphate uridylyltransferase
AVL56_RS01195	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AVL56_RS01205	COG0629	single-stranded DNA binding
AVL56_RS01220	COG0745	RESPONSE REGULATOR receiver
AVL56_RS01230	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AVL56_RS01260	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVL56_RS01285	COG1349	DNA-binding transcription factor activity
AVL56_RS01325	COG3267	Type II secretory pathway component ExeA
AVL56_RS01325	COG3409	Peptidoglycan-binding domain 1 protein
AVL56_RS01335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AVL56_RS01340	COG1459	type II secretion system
AVL56_RS01350	COG2165	general secretion pathway protein
AVL56_RS01355	COG2165	general secretion pathway protein
AVL56_RS01380	COG1077	Cell shape determining protein MreB Mrl
AVL56_RS01385	COG1792	Involved in formation and maintenance of cell shape
AVL56_RS01390	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AVL56_RS01400	COG1530	ribonuclease E activity
AVL56_RS01410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVL56_RS01415	COG0312	modulator of DNA gyrase
AVL56_RS01425	COG3028	Belongs to the UPF0307 family
AVL56_RS01430	COG0312	modulator of DNA gyrase
AVL56_RS01445	COG0745	RESPONSE REGULATOR receiver
AVL56_RS01450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVL56_RS01450	COG4191	Histidine kinase
AVL56_RS01455	COG0297	glycogen (starch) synthase activity
AVL56_RS01465	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AVL56_RS01475	COG1194	a g-specific adenine glycosylase
AVL56_RS01530	COG0745	RESPONSE REGULATOR receiver
AVL56_RS01540	COG0835	chemotaxis
AVL56_RS01555	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AVL56_RS01560	COG2201	protein-glutamate methylesterase activity
AVL56_RS01575	COG0501	Belongs to the peptidase M48B family
AVL56_RS01610	COG1609	Transcriptional regulator
AVL56_RS01615	COG0673	inositol 2-dehydrogenase activity
AVL56_RS01625	COG2211	Major facilitator Superfamily
AVL56_RS01680	COG1454	alcohol dehydrogenase
AVL56_RS01700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AVL56_RS01705	COG0051	transcription antitermination factor activity, RNA binding
AVL56_RS01720	COG0089	rRNA binding
AVL56_RS01730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AVL56_RS01740	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AVL56_RS01755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AVL56_RS01760	COG0438	transferase activity, transferring glycosyl groups
AVL56_RS01765	COG0859	PFAM glycosyl transferase family 9
AVL56_RS01770	COG1519	Transferase
AVL56_RS01795	COG0339	signal peptide processing
AVL56_RS01805	COG0788	formyltetrahydrofolate deformylase activity
AVL56_RS01815	COG1643	Atp-dependent helicase
AVL56_RS01820	COG2951	lytic endotransglycosylase activity
AVL56_RS01830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AVL56_RS01840	COG2354	Protein conserved in bacteria
AVL56_RS01865	COG0004	ammonium transporteR
AVL56_RS01870	COG0405	Gamma-glutamyltransferase
AVL56_RS01875	COG2837	iron assimilation
AVL56_RS01890	COG0540	Belongs to the ATCase OTCase family
AVL56_RS01915	COG2205	protein histidine kinase activity
AVL56_RS01915	COG5002	protein histidine kinase activity
AVL56_RS01915	COG0784	Response regulator, receiver
AVL56_RS01940	COG1012	belongs to the aldehyde dehydrogenase family
AVL56_RS01950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVL56_RS01960	COG0512	Glutamine amidotransferase of anthranilate synthase
AVL56_RS01965	COG0180	Tryptophanyl-tRNA synthetase
AVL56_RS01970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AVL56_RS01990	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AVL56_RS02000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AVL56_RS02035	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AVL56_RS02040	COG0281	malic enzyme
AVL56_RS02045	COG0625	glutathione transferase activity
AVL56_RS02080	COG5001	Diguanylate cyclase
AVL56_RS02080	COG3300	MHYT domain
AVL56_RS02085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AVL56_RS02085	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AVL56_RS02095	COG0137	argininosuccinate synthase activity
AVL56_RS02100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AVL56_RS02115	COG1803	Methylglyoxal synthase
AVL56_RS02125	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AVL56_RS02140	COG0745	RESPONSE REGULATOR receiver
AVL56_RS02145	COG2205	protein histidine kinase activity
AVL56_RS02150	COG2267	carboxylic ester hydrolase activity
AVL56_RS02155	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AVL56_RS02170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AVL56_RS02180	COG4942	peptidase
AVL56_RS02190	COG2861	carbohydrate metabolic process
AVL56_RS02200	COG0584	glycerophosphoryl diester phosphodiesterase
AVL56_RS02215	COG1162	GTPase activity
AVL56_RS02220	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AVL56_RS02240	COG0457	Tetratricopeptide repeat
AVL56_RS02255	COG0028	Belongs to the TPP enzyme family
AVL56_RS02275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVL56_RS02280	COG0805	protein transport
AVL56_RS02305	COG0248	Ppx GppA phosphatase
AVL56_RS02310	COG0513	Belongs to the DEAD box helicase family
AVL56_RS02315	COG3118	belongs to the thioredoxin family
AVL56_RS02320	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AVL56_RS02325	COG1473	amidohydrolase
AVL56_RS02330	COG0784	Response regulator, receiver
AVL56_RS02330	COG2205	protein histidine kinase activity
AVL56_RS02335	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AVL56_RS02340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AVL56_RS02345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AVL56_RS02360	COG0783	Belongs to the Dps family
AVL56_RS02365	COG2133	pyrroloquinoline quinone binding
AVL56_RS02375	COG3118	belongs to the thioredoxin family
AVL56_RS02385	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AVL56_RS02395	COG1012	belongs to the aldehyde dehydrogenase family
AVL56_RS02410	COG1757	Na H antiporter
AVL56_RS02435	COG3876	Protein conserved in bacteria
AVL56_RS02440	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AVL56_RS02460	COG0346	lactoylglutathione lyase activity
AVL56_RS02475	COG0840	transmembrane signaling receptor activity
AVL56_RS02535	COG4115	mRNA cleavage
AVL56_RS02540	COG2161	toxin-antitoxin pair type II binding
AVL56_RS02635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVL56_RS02690	COG0183	Belongs to the thiolase family
AVL56_RS02695	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVL56_RS02695	COG1024	Enoyl-CoA hydratase
AVL56_RS02705	COG0006	proline dipeptidase activity
AVL56_RS02715	COG0142	geranyltranstransferase activity
AVL56_RS02775	COG1238	metal cluster binding
AVL56_RS02785	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AVL56_RS02790	COG0585	pseudouridine synthase activity
AVL56_RS02805	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AVL56_RS02815	COG0840	transmembrane signaling receptor activity
AVL56_RS02820	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AVL56_RS02820	COG0506	proline dehydrogenase activity
AVL56_RS02820	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AVL56_RS02835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVL56_RS02850	COG4991	sh3 domain protein
AVL56_RS02855	COG3025	triphosphatase activity
AVL56_RS02870	COG0494	nUDIX hydrolase
AVL56_RS02875	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
AVL56_RS02880	COG0730	response to heat
AVL56_RS02885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AVL56_RS02890	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AVL56_RS02895	COG2201	protein-glutamate methylesterase activity
AVL56_RS02900	COG3706	GGDEF domain
AVL56_RS02905	COG5002	protein histidine kinase activity
AVL56_RS02905	COG0784	Response regulator, receiver
AVL56_RS02925	COG0564	pseudouridine synthase activity
AVL56_RS02935	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AVL56_RS02950	COG1802	Transcriptional regulator
AVL56_RS02955	COG3119	arylsulfatase activity
AVL56_RS02960	COG1012	belongs to the aldehyde dehydrogenase family
AVL56_RS02965	COG1028	Short-chain dehydrogenase reductase Sdr
AVL56_RS02970	COG1063	alcohol dehydrogenase
AVL56_RS02975	COG4948	Mandelate Racemase Muconate Lactonizing
AVL56_RS02980	COG2814	Major facilitator Superfamily
AVL56_RS02985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVL56_RS03000	COG2124	cytochrome p450
AVL56_RS03100	COG3119	arylsulfatase activity
AVL56_RS03135	COG3119	arylsulfatase activity
AVL56_RS03140	COG3119	arylsulfatase activity
AVL56_RS03150	COG1648	precorrin-2 dehydrogenase activity
AVL56_RS03150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AVL56_RS03170	COG1538	Outer membrane efflux protein
AVL56_RS03175	COG0494	nUDIX hydrolase
AVL56_RS03190	COG3150	esterase
AVL56_RS03205	COG4251	negative regulation of phosphorylation
AVL56_RS03210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVL56_RS03230	COG1509	lysine 2,3-aminomutase activity
AVL56_RS03235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AVL56_RS03260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AVL56_RS03275	COG0271	Belongs to the BolA IbaG family
AVL56_RS03280	COG0671	phosphoesterase, PA-phosphatase related
AVL56_RS03290	COG3707	response regulator
AVL56_RS03300	COG0659	secondary active sulfate transmembrane transporter activity
AVL56_RS03305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AVL56_RS03310	COG2146	nitrite reductase [NAD(P)H] activity
AVL56_RS03315	COG0243	molybdopterin cofactor binding
AVL56_RS03320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AVL56_RS03320	COG1648	precorrin-2 dehydrogenase activity
AVL56_RS03325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AVL56_RS03335	COG1116	anion transmembrane transporter activity
AVL56_RS03335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVL56_RS03340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVL56_RS03345	COG1116	anion transmembrane transporter activity
AVL56_RS03360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AVL56_RS03365	COG4206	TonB-dependent receptor
AVL56_RS03370	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AVL56_RS03375	COG0348	domain, Protein
AVL56_RS03390	COG1960	acyl-CoA dehydrogenase activity
AVL56_RS03395	COG1028	Short-chain dehydrogenase reductase Sdr
AVL56_RS03415	COG4948	Mandelate Racemase Muconate Lactonizing
AVL56_RS03435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVL56_RS03460	COG0358	DNA primase activity
AVL56_RS03465	COG1610	YqeY-like protein
AVL56_RS03485	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AVL56_RS03490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AVL56_RS03505	COG0537	adenosine 5'-monophosphoramidase activity
AVL56_RS03520	COG3135	benzoate transporter
AVL56_RS03525	COG1396	sequence-specific DNA binding
AVL56_RS03530	COG2974	May be involved in recombination
AVL56_RS03535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVL56_RS03535	COG4191	Histidine kinase
AVL56_RS03540	COG0745	RESPONSE REGULATOR receiver
AVL56_RS03545	COG5002	protein histidine kinase activity
AVL56_RS03575	COG0811	peptide transport
AVL56_RS03580	COG0811	peptide transport
AVL56_RS03585	COG0848	biopolymer transport protein
AVL56_RS03590	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AVL56_RS03600	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AVL56_RS03605	COG3437	response regulator, receiver
AVL56_RS03625	COG2133	pyrroloquinoline quinone binding
AVL56_RS03630	COG1049	propionate catabolic process, 2-methylcitrate cycle
AVL56_RS03650	COG0527	aspartate kinase activity
AVL56_RS03655	COG0840	transmembrane signaling receptor activity
AVL56_RS03660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AVL56_RS03670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AVL56_RS03675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AVL56_RS03680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVL56_RS03685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AVL56_RS03690	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AVL56_RS03700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AVL56_RS03720	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AVL56_RS03730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AVL56_RS03735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AVL56_RS03740	COG3956	TIGRFAM MazG family protein
AVL56_RS03760	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AVL56_RS03765	COG1595	DNA-templated transcription, initiation
AVL56_RS03775	COG4206	TonB-dependent receptor
AVL56_RS03785	COG1473	amidohydrolase
AVL56_RS03790	COG0723	plastoquinol--plastocyanin reductase activity
AVL56_RS03795	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AVL56_RS03800	COG2857	Cytochrome c1
AVL56_RS03805	COG0625	glutathione transferase activity
AVL56_RS03810	COG2969	positive regulation of protein catabolic process
AVL56_RS03815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVL56_RS03815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVL56_RS03820	COG2207	Transcriptional regulator
AVL56_RS03820	COG3708	Transcriptional regulator
AVL56_RS03830	COG2239	Acts as a magnesium transporter
AVL56_RS03835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVL56_RS03855	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AVL56_RS03860	COG1137	ATPase activity
AVL56_RS03875	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AVL56_RS03890	COG1127	ABC transporter
AVL56_RS03895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AVL56_RS03900	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AVL56_RS03905	COG2854	intermembrane phospholipid transfer
AVL56_RS03915	COG5007	Belongs to the BolA IbaG family
AVL56_RS03925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVL56_RS03930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVL56_RS03940	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AVL56_RS03955	COG2207	Transcriptional regulator
AVL56_RS03970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVL56_RS03985	COG3300	MHYT domain
AVL56_RS03985	COG5001	Diguanylate cyclase
AVL56_RS03990	COG0784	Response regulator, receiver
AVL56_RS03990	COG2205	protein histidine kinase activity
AVL56_RS04000	COG2207	Transcriptional regulator
AVL56_RS04005	COG1979	alcohol dehydrogenase
AVL56_RS04030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AVL56_RS04040	COG0126	phosphoglycerate kinase activity
AVL56_RS04045	COG3588	fructose-bisphosphate aldolase
AVL56_RS04050	COG4946	Tricorn protease homolog
AVL56_RS04050	COG1506	peptidase
AVL56_RS04050	COG0823	Involved in the tonB-independent uptake of proteins
AVL56_RS04055	COG0248	Ppx GppA phosphatase
AVL56_RS04060	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AVL56_RS04070	COG0573	inorganic phosphate transmembrane transporter activity
AVL56_RS04075	COG0581	inorganic phosphate transmembrane transporter activity
AVL56_RS04080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AVL56_RS04090	COG0306	phosphate transporter
AVL56_RS04100	COG0583	DNA-binding transcription factor activity
AVL56_RS04125	COG1272	protein, Hemolysin III
AVL56_RS04145	COG0477	Major facilitator Superfamily
AVL56_RS04150	COG1609	Transcriptional regulator
AVL56_RS04150	COG2207	Transcriptional regulator
AVL56_RS04155	COG1070	Carbohydrate kinase
AVL56_RS04160	COG2115	Belongs to the xylose isomerase family
AVL56_RS04165	COG4447	cellulose binding
AVL56_RS04165	COG5520	Belongs to the glycosyl hydrolase 30 family
AVL56_RS04165	COG3291	Pkd domain containing protein
AVL56_RS04170	COG2207	Transcriptional regulator
AVL56_RS04185	COG1472	Belongs to the glycosyl hydrolase 3 family
AVL56_RS04190	COG1846	Transcriptional regulator
AVL56_RS04195	COG1764	response to oxidative stress
AVL56_RS04210	COG1739	Uncharacterized protein family UPF0029
AVL56_RS04220	COG0420	3'-5' exonuclease activity
AVL56_RS04225	COG0419	ATPase involved in DNA repair
AVL56_RS04230	COG3706	GGDEF domain
AVL56_RS04240	COG2971	BadF BadG BcrA BcrD
AVL56_RS04245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AVL56_RS04255	COG0488	(ABC) transporter
AVL56_RS04290	COG4667	esterase of the alpha-beta hydrolase superfamily
AVL56_RS04360	COG0582	viral genome integration into host DNA
AVL56_RS04420	COG2003	Belongs to the UPF0758 family
AVL56_RS04455	COG1346	cytolysis
AVL56_RS04485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AVL56_RS04495	COG0513	Belongs to the DEAD box helicase family
AVL56_RS04505	COG3409	Peptidoglycan-binding domain 1 protein
AVL56_RS04505	COG3267	Type II secretory pathway component ExeA
AVL56_RS04515	COG0784	Response regulator, receiver
AVL56_RS04515	COG3437	response regulator, receiver
AVL56_RS04520	COG0066	3-isopropylmalate dehydratase activity
AVL56_RS04530	COG0473	3-isopropylmalate dehydrogenase activity
AVL56_RS04535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVL56_RS04565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AVL56_RS04580	COG4555	ABC transporter
AVL56_RS04585	COG1668	transmembrane transport
AVL56_RS04605	COG4133	protoheme IX ABC transporter activity
AVL56_RS04610	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AVL56_RS04615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AVL56_RS04620	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AVL56_RS04630	COG1138	Cytochrome C-type biogenesis protein
AVL56_RS04635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AVL56_RS04650	COG2853	Lipoprotein
AVL56_RS04655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AVL56_RS04680	COG1682	transport, permease protein
AVL56_RS04710	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AVL56_RS04715	COG1555	photosystem II stabilization
AVL56_RS04715	COG1596	polysaccharide export
AVL56_RS04720	COG0473	3-isopropylmalate dehydrogenase activity
AVL56_RS04735	COG1611	Belongs to the LOG family
AVL56_RS04745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AVL56_RS04745	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AVL56_RS04815	COG0564	pseudouridine synthase activity
AVL56_RS04830	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AVL56_RS04835	COG0024	Methionine aminopeptidase
AVL56_RS04840	COG0052	Belongs to the universal ribosomal protein uS2 family
AVL56_RS04850	COG0528	UMP kinase activity
AVL56_RS04860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AVL56_RS04865	COG0575	Belongs to the CDS family
AVL56_RS04870	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AVL56_RS04875	COG0750	zinc metalloprotease
AVL56_RS04890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AVL56_RS04895	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVL56_RS04910	COG0587	DNA-directed DNA polymerase activity
AVL56_RS04915	COG0825	malonyl-CoA metabolic process
AVL56_RS04920	COG0037	tRNA processing
AVL56_RS04950	COG0047	phosphoribosylformylglycinamidine synthase activity
AVL56_RS04950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AVL56_RS04955	COG2840	Smr protein MutS2
AVL56_RS04985	COG0513	Belongs to the DEAD box helicase family
AVL56_RS04990	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AVL56_RS04995	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AVL56_RS05000	COG0583	DNA-binding transcription factor activity
AVL56_RS05020	COG1760	l-serine dehydratase
AVL56_RS05025	COG0494	nUDIX hydrolase
AVL56_RS05030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AVL56_RS05040	COG1322	Protein conserved in bacteria
AVL56_RS05045	COG1404	Belongs to the peptidase S8 family
AVL56_RS05050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AVL56_RS05055	COG0022	dehydrogenase e1 component
AVL56_RS05060	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVL56_RS05065	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AVL56_RS05070	COG0515	serine threonine protein kinase
AVL56_RS05075	COG1946	Acyl-CoA thioesterase
AVL56_RS05085	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AVL56_RS05095	COG1956	GAF domain-containing protein
AVL56_RS05110	COG0793	Belongs to the peptidase S41A family
AVL56_RS05115	COG0733	neurotransmitter:sodium symporter activity
AVL56_RS05120	COG1757	Na H antiporter
AVL56_RS05125	COG0308	aminopeptidase N
AVL56_RS05155	COG2902	Dehydrogenase
AVL56_RS05160	COG0167	dihydroorotate dehydrogenase activity
AVL56_RS05175	COG0488	(ABC) transporter
AVL56_RS05185	COG3130	regulation of translation
AVL56_RS05190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AVL56_RS05200	COG0415	Belongs to the DNA photolyase family
AVL56_RS05205	COG0415	Belongs to the DNA photolyase family
AVL56_RS05210	COG3046	protein related to deoxyribodipyrimidine photolyase
AVL56_RS05235	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AVL56_RS05240	COG0589	response to stress
AVL56_RS05250	COG0069	glutamate synthase activity
AVL56_RS05265	COG2193	ferroxidase activity
AVL56_RS05275	COG3278	Belongs to the heme-copper respiratory oxidase family
AVL56_RS05290	COG2010	Cytochrome c
AVL56_RS05315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVL56_RS05325	COG0037	tRNA processing
AVL56_RS05330	COG1752	Esterase of the alpha-beta hydrolase superfamily
AVL56_RS05395	COG1280	lysine exporter protein (LysE YggA)
AVL56_RS05405	COG2897	thiosulfate sulfurtransferase activity
AVL56_RS05410	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AVL56_RS05415	COG3148	PFAM DTW domain containing protein
AVL56_RS05460	COG0322	excinuclease ABC activity
AVL56_RS05465	COG2197	response regulator
AVL56_RS05470	COG1741	Belongs to the pirin family
AVL56_RS05480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AVL56_RS05510	COG0642	Histidine kinase
AVL56_RS05515	COG0745	RESPONSE REGULATOR receiver
AVL56_RS05540	COG0670	Belongs to the BI1 family
AVL56_RS05550	COG2923	Belongs to the DsrF TusC family
AVL56_RS05560	COG2920	part of a sulfur-relay system
AVL56_RS05565	COG0561	phosphatase activity
AVL56_RS05580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AVL56_RS05585	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AVL56_RS05590	COG0531	amino acid
AVL56_RS05590	COG1674	ftsk spoiiie
AVL56_RS05600	COG0686	Belongs to the AlaDH PNT family
AVL56_RS05605	COG0284	orotidine-5'-phosphate decarboxylase activity
AVL56_RS05610	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AVL56_RS05615	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AVL56_RS05625	COG0776	regulation of translation
AVL56_RS05630	COG0539	negative regulation of cytoplasmic translation
AVL56_RS05635	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AVL56_RS05640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AVL56_RS05645	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AVL56_RS05660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AVL56_RS05665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AVL56_RS05670	COG0633	Ferredoxin
AVL56_RS05675	COG5002	protein histidine kinase activity
AVL56_RS05815	COG1131	(ABC) transporter
AVL56_RS05850	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AVL56_RS05855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVL56_RS05865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AVL56_RS05875	COG4783	chaperone-mediated protein folding
AVL56_RS05885	COG1393	Belongs to the ArsC family
AVL56_RS05920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AVL56_RS05955	COG0572	uridine kinase
AVL56_RS05960	COG3769	mannosylglycerate metabolic process
AVL56_RS05965	COG1215	transferase activity, transferring glycosyl groups
AVL56_RS05975	COG0303	'Molybdopterin
AVL56_RS05980	COG0534	Mate efflux family protein
AVL56_RS05995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVL56_RS06000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AVL56_RS06010	COG0405	Gamma-glutamyltransferase
AVL56_RS06015	COG1024	Enoyl-CoA hydratase
AVL56_RS06050	COG1448	Aminotransferase
AVL56_RS06055	COG1671	Belongs to the UPF0178 family
AVL56_RS06060	COG1028	Short-chain dehydrogenase reductase Sdr
AVL56_RS06070	COG1960	acyl-CoA dehydrogenase activity
AVL56_RS06075	COG1917	Cupin 2, conserved barrel domain protein
AVL56_RS06075	COG2207	Transcriptional regulator
AVL56_RS06125	COG0596	Alpha beta hydrolase
AVL56_RS06135	COG0716	FMN binding
AVL56_RS06155	COG3265	gluconokinase activity
AVL56_RS06160	COG1609	Transcriptional regulator
AVL56_RS06170	COG1984	allophanate hydrolase subunit 2
AVL56_RS06180	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AVL56_RS06185	COG2996	Protein conserved in bacteria
AVL56_RS06190	COG1765	OsmC-like protein
AVL56_RS06195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVL56_RS06205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVL56_RS06220	COG0436	Aminotransferase
AVL56_RS06225	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AVL56_RS06230	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AVL56_RS06240	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AVL56_RS06250	COG1238	metal cluster binding
AVL56_RS06295	COG4628	conserved protein (DUF2132)
AVL56_RS06305	COG0454	-acetyltransferase
AVL56_RS06310	COG1119	ATPase activity
AVL56_RS06320	COG1185	polyribonucleotide nucleotidyltransferase activity
AVL56_RS06335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AVL56_RS06340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AVL56_RS06345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVL56_RS06385	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AVL56_RS06390	COG0149	triose-phosphate isomerase activity
AVL56_RS06395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AVL56_RS06400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AVL56_RS06410	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AVL56_RS06415	COG1534	Rna-binding protein
AVL56_RS06425	COG1067	ATP-dependent peptidase activity
AVL56_RS06430	COG0495	leucyl-tRNA aminoacylation
AVL56_RS06440	COG1466	dna polymerase III delta subunit
AVL56_RS06445	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AVL56_RS06450	COG0799	negative regulation of ribosome biogenesis
AVL56_RS06455	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AVL56_RS06460	COG0768	penicillin binding
AVL56_RS06465	COG0772	Belongs to the SEDS family
AVL56_RS06470	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AVL56_RS06475	COG1686	Belongs to the peptidase S11 family
AVL56_RS06480	COG2921	Belongs to the UPF0250 family
AVL56_RS06485	COG0321	lipoyl(octanoyl) transferase activity
AVL56_RS06490	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AVL56_RS06500	COG0252	asparaginase activity
AVL56_RS06510	COG0778	Nitroreductase
AVL56_RS06525	COG0616	signal peptide processing
AVL56_RS06545	COG0492	ferredoxin-NADP+ reductase activity
AVL56_RS06550	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AVL56_RS06555	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AVL56_RS06560	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AVL56_RS06565	COG0542	response to heat
AVL56_RS06570	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AVL56_RS06575	COG1278	Cold shock
AVL56_RS06585	COG1187	pseudouridine synthase activity
AVL56_RS06590	COG0482	sulfurtransferase activity
AVL56_RS06595	COG2915	High frequency lysogenization protein hflD homolog
AVL56_RS06600	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AVL56_RS06610	COG2850	peptidyl-arginine hydroxylation
AVL56_RS06625	COG0277	FAD linked oxidase domain protein
AVL56_RS06625	COG0247	lactate metabolic process
AVL56_RS06630	COG3123	guanosine phosphorylase activity
AVL56_RS06635	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AVL56_RS06675	COG1695	Transcriptional regulator
AVL56_RS06690	COG1077	Cell shape determining protein MreB Mrl
AVL56_RS06720	COG3265	gluconokinase activity
AVL56_RS06730	COG1028	Short-chain dehydrogenase reductase Sdr
AVL56_RS06745	COG1609	Transcriptional regulator
AVL56_RS06750	COG0679	Auxin Efflux Carrier
AVL56_RS06770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVL56_RS06770	COG0574	Belongs to the PEP-utilizing enzyme family
AVL56_RS06790	COG1942	4-Oxalocrotonate Tautomerase
AVL56_RS06810	COG1714	RDD family
AVL56_RS06835	COG0702	epimerase
AVL56_RS06845	COG0084	hydrolase, TatD family'
AVL56_RS06850	COG0470	DNA polymerase III
AVL56_RS06860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AVL56_RS06865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AVL56_RS06870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVL56_RS06875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVL56_RS06890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AVL56_RS06895	COG0416	fatty acid biosynthetic process
AVL56_RS06905	COG1399	metal-binding, possibly nucleic acid-binding protein
AVL56_RS06910	COG0424	maF-like protein
AVL56_RS06915	COG0546	phosphoglycolate phosphatase activity
AVL56_RS06925	COG1530	ribonuclease E activity
AVL56_RS06945	COG2153	protein acetylation
AVL56_RS06965	COG0625	glutathione transferase activity
AVL56_RS06980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AVL56_RS06990	COG0583	DNA-binding transcription factor activity
AVL56_RS07000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AVL56_RS07005	COG3724	N-succinylarginine dihydrolase activity
AVL56_RS07015	COG1301	dicarboxylic acid transport
AVL56_RS07020	COG4591	ABC-type transport system involved in lipoprotein release permease component
AVL56_RS07030	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AVL56_RS07065	COG0328	RNA-DNA hybrid ribonuclease activity
AVL56_RS07070	COG3321	synthase
AVL56_RS07070	COG0604	alcohol dehydrogenase
AVL56_RS07090	COG1643	Atp-dependent helicase
AVL56_RS07130	COG3437	response regulator, receiver
AVL56_RS07130	COG4999	Histidine kinase
AVL56_RS07130	COG2205	protein histidine kinase activity
AVL56_RS07130	COG3850	Histidine kinase
AVL56_RS07135	COG2925	Exonuclease
AVL56_RS07150	COG0183	Belongs to the thiolase family
AVL56_RS07155	COG0789	Transcriptional regulator
AVL56_RS07160	COG1960	acyl-CoA dehydrogenase activity
AVL56_RS07165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AVL56_RS07170	COG1024	Enoyl-CoA hydratase
AVL56_RS07175	COG4770	biotin carboxylase activity
AVL56_RS07205	COG1957	nucleoside hydrolase
AVL56_RS07220	COG2814	Major facilitator Superfamily
AVL56_RS07255	COG0708	Exodeoxyribonuclease III
AVL56_RS07275	COG4591	ABC-type transport system involved in lipoprotein release permease component
AVL56_RS07285	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AVL56_RS07295	COG2096	Adenosyltransferase
AVL56_RS07305	COG1472	Belongs to the glycosyl hydrolase 3 family
AVL56_RS07315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AVL56_RS07330	COG0072	phenylalanine-tRNA ligase activity
AVL56_RS07330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVL56_RS07345	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AVL56_RS07345	COG2755	lipolytic protein G-D-S-L family
AVL56_RS07350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AVL56_RS07350	COG2755	lipolytic protein G-D-S-L family
AVL56_RS07365	COG0438	transferase activity, transferring glycosyl groups
AVL56_RS07385	COG0438	transferase activity, transferring glycosyl groups
AVL56_RS07395	COG1216	Glycosyl transferase, family 2
AVL56_RS07410	COG0438	transferase activity, transferring glycosyl groups
AVL56_RS07445	COG4464	protein tyrosine phosphatase activity
AVL56_RS07450	COG0489	protein tyrosine kinase activity
AVL56_RS07455	COG1596	polysaccharide export
AVL56_RS07485	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AVL56_RS07495	COG1028	Short-chain dehydrogenase reductase Sdr
AVL56_RS07525	COG0154	amidase activity
AVL56_RS07535	COG0730	response to heat
AVL56_RS07540	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AVL56_RS07555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AVL56_RS07560	COG2233	PERMEase
AVL56_RS07575	COG0784	Response regulator, receiver
AVL56_RS07575	COG5002	protein histidine kinase activity
AVL56_RS07585	COG5001	Diguanylate cyclase
AVL56_RS07585	COG3300	MHYT domain
AVL56_RS07595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AVL56_RS07600	COG2252	PERMEase
AVL56_RS07615	COG1309	transcriptional regulator
AVL56_RS07625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVL56_RS07640	COG2351	hydroxyisourate hydrolase activity
AVL56_RS07645	COG0402	S-adenosylhomocysteine deaminase activity
AVL56_RS07655	COG5002	protein histidine kinase activity
AVL56_RS07655	COG5001	Diguanylate cyclase
AVL56_RS07655	COG3447	MASE1 domain protein
AVL56_RS07675	COG3706	GGDEF domain
AVL56_RS07690	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AVL56_RS07710	COG2190	(PTS) system
AVL56_RS07710	COG2211	Major facilitator Superfamily
AVL56_RS07715	COG1393	Belongs to the ArsC family
AVL56_RS07745	COG2988	succinylglutamate desuccinylase activity
AVL56_RS07755	COG0058	SHG alpha-glucan phosphorylase activity
AVL56_RS07760	COG0033	Phosphoglucomutase
AVL56_RS07765	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AVL56_RS07770	COG0714	Associated with various cellular activities
AVL56_RS07785	COG2116	formate transmembrane transporter activity
AVL56_RS07790	COG0515	serine threonine protein kinase
AVL56_RS07790	COG2815	serine threonine protein kinase
AVL56_RS07795	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
AVL56_RS07800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AVL56_RS07820	COG0583	DNA-binding transcription factor activity
AVL56_RS07830	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AVL56_RS07840	COG3437	response regulator, receiver
AVL56_RS07840	COG0784	Response regulator, receiver
AVL56_RS07845	COG2890	protein-(glutamine-N5) methyltransferase activity
AVL56_RS07855	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AVL56_RS07860	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AVL56_RS07865	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AVL56_RS07875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AVL56_RS07880	COG5001	Diguanylate cyclase
AVL56_RS07890	COG1064	alcohol dehydrogenase
AVL56_RS07905	COG0012	GTP binding
AVL56_RS07910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AVL56_RS07935	COG1115	amino acid carrier protein
AVL56_RS07940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVL56_RS07955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVL56_RS07965	COG1702	phosphate starvation-inducible protein PhoH
AVL56_RS07975	COG4535	Mg2 and Co2 transporter CorC
AVL56_RS07980	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AVL56_RS07985	COG0280	phosphate acetyltransferase
AVL56_RS07985	COG0857	belongs to the CobB CobQ family
AVL56_RS07995	COG0071	Belongs to the small heat shock protein (HSP20) family
AVL56_RS08025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AVL56_RS08030	COG0505	Belongs to the CarA family
AVL56_RS08035	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AVL56_RS08050	COG5001	Diguanylate cyclase
AVL56_RS08050	COG4251	negative regulation of phosphorylation
AVL56_RS08050	COG3706	GGDEF domain
AVL56_RS08050	COG2203	Gaf domain
AVL56_RS08055	COG3909	cytochrome
AVL56_RS08060	COG0484	heat shock protein binding
AVL56_RS08070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AVL56_RS08075	COG2205	protein histidine kinase activity
AVL56_RS08075	COG0784	Response regulator, receiver
AVL56_RS08085	COG4771	TonB-dependent receptor
AVL56_RS08090	COG2610	gluconate transmembrane transporter activity
AVL56_RS08095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVL56_RS08105	COG1028	Short-chain dehydrogenase reductase Sdr
AVL56_RS08110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AVL56_RS08115	COG0497	DNA recombination
AVL56_RS08120	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVL56_RS08125	COG0500	methyltransferase
AVL56_RS08130	COG2733	membrane
AVL56_RS08145	COG0110	maltose O-acetyltransferase activity
AVL56_RS08150	COG0656	L-ascorbic acid biosynthetic process
AVL56_RS08165	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AVL56_RS08170	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AVL56_RS08175	COG0009	L-threonylcarbamoyladenylate synthase
AVL56_RS08180	COG0613	PHP domain protein
AVL56_RS08185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AVL56_RS08190	COG0512	Glutamine amidotransferase of anthranilate synthase
AVL56_RS08195	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AVL56_RS08200	COG0135	phosphoribosylanthranilate isomerase activity
AVL56_RS08200	COG0134	indole-3-glycerol-phosphate synthase activity
AVL56_RS08210	COG0159	tryptophan synthase activity
AVL56_RS08215	COG2350	Protein conserved in bacteria
AVL56_RS08235	COG2205	protein histidine kinase activity
AVL56_RS08240	COG0628	permease
AVL56_RS08245	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AVL56_RS08250	COG1090	epimerase
AVL56_RS08255	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AVL56_RS08260	COG4181	ATPase activity
AVL56_RS08280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AVL56_RS08305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVL56_RS08325	COG0745	RESPONSE REGULATOR receiver
AVL56_RS08335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AVL56_RS08340	COG5265	(ABC) transporter
AVL56_RS08355	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AVL56_RS08365	COG4139	cobalamin transport
AVL56_RS08370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AVL56_RS08385	COG2226	methyltransferase
AVL56_RS08385	COG1073	alpha beta
AVL56_RS08390	COG0156	8-amino-7-oxononanoate synthase activity
AVL56_RS08415	COG0456	acetyltransferase
AVL56_RS08420	COG0189	ligase activity
AVL56_RS08435	COG0017	Asparaginyl-tRNA synthetase
AVL56_RS08445	COG2995	paraquat-inducible protein a
AVL56_RS08450	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AVL56_RS08450	COG3008	intermembrane lipid transfer
AVL56_RS08480	COG0583	DNA-binding transcription factor activity
AVL56_RS08485	COG1309	transcriptional regulator
AVL56_RS08495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVL56_RS08500	COG0517	IMP dehydrogenase activity
AVL56_RS08515	COG0583	DNA-binding transcription factor activity
AVL56_RS08520	COG3038	cytochrome b561
AVL56_RS08530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL56_RS08560	COG2271	Major facilitator Superfamily
AVL56_RS08565	COG2205	protein histidine kinase activity
AVL56_RS08565	COG0784	Response regulator, receiver
AVL56_RS08640	COG3459	Glycosyltransferase 36 associated
AVL56_RS08655	COG0330	HflC and HflK could
AVL56_RS08660	COG2199	diguanylate cyclase activity
AVL56_RS08660	COG2203	Gaf domain
AVL56_RS08670	COG1917	Cupin 2, conserved barrel domain protein
AVL56_RS08670	COG2207	Transcriptional regulator
AVL56_RS08700	COG4771	TonB-dependent receptor
AVL56_RS08725	COG4771	TonB-dependent receptor
AVL56_RS08730	COG1609	Transcriptional regulator
AVL56_RS08760	COG0583	DNA-binding transcription factor activity
AVL56_RS08765	COG3384	dioxygenase
AVL56_RS08815	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AVL56_RS08850	COG0667	Aldo Keto reductase
AVL56_RS08875	COG2159	amidohydrolase
AVL56_RS08880	COG2828	Protein conserved in bacteria
AVL56_RS08885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AVL56_RS08900	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AVL56_RS08920	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AVL56_RS08925	COG2885	chlorophyll binding
AVL56_RS08930	COG0823	Involved in the tonB-independent uptake of proteins
AVL56_RS08945	COG0811	peptide transport
AVL56_RS08950	COG0824	Thioesterase
AVL56_RS08955	COG2255	four-way junction helicase activity
AVL56_RS08960	COG0632	four-way junction helicase activity
AVL56_RS08965	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AVL56_RS08970	COG0494	nUDIX hydrolase
AVL56_RS08975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AVL56_RS08990	COG2204	response regulator
AVL56_RS09000	COG2205	protein histidine kinase activity
AVL56_RS09030	COG0023	Translation Initiation Factor
AVL56_RS09035	COG0745	RESPONSE REGULATOR receiver
AVL56_RS09040	COG1605	Chorismate mutase
AVL56_RS09040	COG0077	Prephenate dehydratase
AVL56_RS09045	COG0840	transmembrane signaling receptor activity
AVL56_RS09050	COG1605	Chorismate mutase
AVL56_RS09050	COG0287	Prephenate dehydrogenase
AVL56_RS09055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AVL56_RS09060	COG2860	membrane
AVL56_RS09075	COG0335	large ribosomal subunit rRNA binding
AVL56_RS09080	COG0336	Belongs to the RNA methyltransferase TrmD family
AVL56_RS09085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AVL56_RS09090	COG0228	four-way junction DNA binding
AVL56_RS09105	COG2873	o-acetylhomoserine
AVL56_RS09110	COG1132	(ABC) transporter
AVL56_RS09115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVL56_RS09125	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AVL56_RS09155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AVL56_RS09160	COG4137	Cytochrome C assembly protein
AVL56_RS09165	COG4536	flavin adenine dinucleotide binding
AVL56_RS09175	COG2062	phosphohistidine phosphatase, SixA
AVL56_RS09180	COG1025	Belongs to the peptidase M16 family
AVL56_RS09195	COG1024	Enoyl-CoA hydratase
AVL56_RS09195	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVL56_RS09205	COG0714	Associated with various cellular activities
AVL56_RS09225	COG2304	oxidoreductase activity
AVL56_RS09250	COG3706	GGDEF domain
AVL56_RS09255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVL56_RS09260	COG0175	sulfate reduction
AVL56_RS09265	COG0529	Catalyzes the synthesis of activated sulfate
AVL56_RS09280	COG0471	metal ion transport
AVL56_RS09280	COG3273	potassium ion transport
AVL56_RS09305	COG0367	asparagine synthase
AVL56_RS09315	COG0602	queuosine metabolic process
AVL56_RS09340	COG0556	nucleotide-excision repair
AVL56_RS09345	COG0534	Mate efflux family protein
AVL56_RS09360	COG4657	Part of a membrane complex involved in electron transport
AVL56_RS09365	COG2878	Part of a membrane complex involved in electron transport
AVL56_RS09370	COG4656	Part of a membrane complex involved in electron transport
AVL56_RS09375	COG4658	electron transport chain
AVL56_RS09380	COG4659	FMN binding
AVL56_RS09385	COG4660	Part of a membrane complex involved in electron transport
AVL56_RS09390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AVL56_RS09405	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AVL56_RS09410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVL56_RS09415	COG0823	Involved in the tonB-independent uptake of proteins
AVL56_RS09415	COG1506	peptidase
AVL56_RS09415	COG4946	Tricorn protease homolog
AVL56_RS09440	COG1278	Cold shock
AVL56_RS09445	COG0346	lactoylglutathione lyase activity
AVL56_RS09450	COG0584	glycerophosphoryl diester phosphodiesterase
AVL56_RS09455	COG2885	chlorophyll binding
AVL56_RS09460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AVL56_RS09465	COG0450	alkyl hydroperoxide reductase
AVL56_RS09490	COG4771	TonB-dependent receptor
AVL56_RS09495	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AVL56_RS09500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AVL56_RS09505	COG2766	serine protein kinase
AVL56_RS09510	COG2718	Belongs to the UPF0229 family
AVL56_RS09515	COG2719	SpoVR family
AVL56_RS09535	COG2890	protein-(glutamine-N5) methyltransferase activity
AVL56_RS09540	COG2840	Smr protein MutS2
AVL56_RS09565	COG1136	(ABC) transporter
AVL56_RS09585	COG2918	glutathione biosynthetic process
AVL56_RS09590	COG0612	Peptidase, M16
AVL56_RS09600	COG0564	pseudouridine synthase activity
AVL56_RS09605	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AVL56_RS09610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AVL56_RS09635	COG2175	clavaminate synthase activity
AVL56_RS09665	COG0583	DNA-binding transcription factor activity
AVL56_RS09680	COG0456	acetyltransferase
AVL56_RS09720	COG1444	tRNA N-acetyltransferase activity
AVL56_RS09735	COG0848	biopolymer transport protein
AVL56_RS09740	COG0811	peptide transport
AVL56_RS09745	COG0811	peptide transport
AVL56_RS09810	COG1522	sequence-specific DNA binding
AVL56_RS09815	COG0625	glutathione transferase activity
AVL56_RS09845	COG1842	Phage shock protein A
AVL56_RS09850	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AVL56_RS09855	COG0747	negative chemotaxis
AVL56_RS09860	COG4168	peptide transport system, permease
AVL56_RS09865	COG4171	peptide transport system, permease
AVL56_RS09870	COG4172	Belongs to the ABC transporter superfamily
AVL56_RS09875	COG4172	Belongs to the ABC transporter superfamily
AVL56_RS09880	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AVL56_RS09895	COG1607	acyl-coa hydrolase
AVL56_RS09935	COG3590	peptidase
AVL56_RS09940	COG1309	transcriptional regulator
AVL56_RS09950	COG0659	secondary active sulfate transmembrane transporter activity
AVL56_RS09955	COG0288	reversible hydration of carbon dioxide
AVL56_RS09960	COG0583	DNA-binding transcription factor activity
AVL56_RS09965	COG0583	DNA-binding transcription factor activity
AVL56_RS09975	COG1410	methionine synthase
AVL56_RS09975	COG0646	methionine synthase
AVL56_RS09980	COG0646	methionine synthase
AVL56_RS09980	COG1410	methionine synthase
AVL56_RS09995	COG0835	chemotaxis
AVL56_RS10005	COG1192	Involved in chromosome partitioning
AVL56_RS10010	COG2201	protein-glutamate methylesterase activity
AVL56_RS10015	COG0643	Histidine kinase
AVL56_RS10015	COG2198	Histidine kinase
AVL56_RS10015	COG0784	Response regulator, receiver
AVL56_RS10020	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AVL56_RS10045	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AVL56_RS10060	COG1987	bacterial-type flagellum assembly
AVL56_RS10110	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AVL56_RS10115	COG1766	The M ring may be actively involved in energy transduction
AVL56_RS10145	COG1086	Polysaccharide biosynthesis protein
AVL56_RS10150	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AVL56_RS10155	COG1083	cytidylyl-transferase
AVL56_RS10165	COG2089	acid synthase
AVL56_RS10180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL56_RS10185	COG1028	Short-chain dehydrogenase reductase Sdr
AVL56_RS10190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AVL56_RS10220	COG2089	acid synthase
AVL56_RS10225	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AVL56_RS10230	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AVL56_RS10270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AVL56_RS10275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AVL56_RS10295	COG1256	bacterial-type flagellum assembly
AVL56_RS10300	COG3951	Flagellar rod assembly protein muramidase FlgJ
AVL56_RS10300	COG1705	Flagellar rod assembly protein muramidase FlgJ
AVL56_RS10320	COG4787	bacterial-type flagellum-dependent cell motility
AVL56_RS10325	COG1749	Flagellar hook protein flgE
AVL56_RS10340	COG1815	bacterial-type flagellum-dependent cell motility
AVL56_RS10345	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AVL56_RS10350	COG0784	Response regulator, receiver
AVL56_RS10350	COG0835	chemotaxis
AVL56_RS10390	COG2197	response regulator
AVL56_RS10395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVL56_RS10405	COG2885	chlorophyll binding
AVL56_RS10520	COG2205	protein histidine kinase activity
AVL56_RS10520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVL56_RS10530	COG0205	6-phosphofructokinase activity
AVL56_RS10535	COG3279	Response regulator of the LytR AlgR family
AVL56_RS10540	COG3275	phosphorelay sensor kinase activity
AVL56_RS10570	COG3081	Nucleoid-associated protein
AVL56_RS10575	COG3082	Protein of unknown function (DUF1414)
AVL56_RS10580	COG3083	sulfuric ester hydrolase activity
AVL56_RS10590	COG2226	methyltransferase
AVL56_RS10595	COG1024	Enoyl-CoA hydratase
AVL56_RS10600	COG1960	acyl-CoA dehydrogenase activity
AVL56_RS10610	COG2084	Dehydrogenase
AVL56_RS10615	COG0386	Belongs to the glutathione peroxidase family
AVL56_RS10620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVL56_RS10625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVL56_RS10630	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AVL56_RS10655	COG0616	signal peptide processing
AVL56_RS10665	COG2267	carboxylic ester hydrolase activity
AVL56_RS10670	COG1028	Short-chain dehydrogenase reductase Sdr
AVL56_RS10680	COG1609	Transcriptional regulator
AVL56_RS10695	COG0366	Alpha amylase catalytic
AVL56_RS10715	COG4667	esterase of the alpha-beta hydrolase superfamily
AVL56_RS10750	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVL56_RS10755	COG0567	Dehydrogenase, E1 component
AVL56_RS10765	COG1053	succinate dehydrogenase
AVL56_RS10770	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AVL56_RS10795	COG0435	Glutathione S-transferase
AVL56_RS10800	COG0579	oxidoreductase
AVL56_RS10805	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AVL56_RS10850	COG1663	tetraacyldisaccharide 4'-kinase activity
AVL56_RS10855	COG1132	(ABC) transporter
AVL56_RS10870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AVL56_RS10880	COG1196	nuclear chromosome segregation
AVL56_RS10900	COG0295	cytidine deaminase activity
AVL56_RS10925	COG0477	Major facilitator Superfamily
AVL56_RS10945	COG2318	DinB family
AVL56_RS10950	COG0457	Tetratricopeptide repeat
AVL56_RS10960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AVL56_RS10970	COG2914	Belongs to the UPF0125 (RnfH) family
AVL56_RS10975	COG2867	negative regulation of translational initiation
AVL56_RS11035	COG4771	TonB-dependent receptor
AVL56_RS11040	COG2814	Major facilitator Superfamily
AVL56_RS11070	COG1012	belongs to the aldehyde dehydrogenase family
AVL56_RS11080	COG1595	DNA-templated transcription, initiation
AVL56_RS11085	COG1595	DNA-templated transcription, initiation
AVL56_RS11115	COG0583	DNA-binding transcription factor activity
AVL56_RS11135	COG3300	MHYT domain
AVL56_RS11135	COG5001	Diguanylate cyclase
AVL56_RS11150	COG3706	GGDEF domain
AVL56_RS11150	COG5001	Diguanylate cyclase
AVL56_RS11150	COG2203	Gaf domain
AVL56_RS11150	COG4251	negative regulation of phosphorylation
AVL56_RS11165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AVL56_RS11170	COG4136	ATPase activity
AVL56_RS11175	COG4135	transport system, permease component
AVL56_RS11180	COG4134	Bacterial extracellular solute-binding protein
AVL56_RS11195	COG4771	TonB-dependent receptor
AVL56_RS11210	COG1032	radical SAM domain protein
AVL56_RS11235	COG4774	siderophore transport
AVL56_RS11275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVL56_RS11275	COG3153	acetyltransferase
AVL56_RS11285	COG0596	Alpha beta hydrolase
AVL56_RS11290	COG3706	GGDEF domain
AVL56_RS11300	COG4269	membrane
AVL56_RS11310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AVL56_RS11325	COG0195	Participates in both transcription termination and antitermination
AVL56_RS11335	COG3437	response regulator, receiver
AVL56_RS11340	COG0784	Response regulator, receiver
AVL56_RS11340	COG2205	protein histidine kinase activity
AVL56_RS11340	COG2198	Histidine kinase
AVL56_RS11360	COG4771	TonB-dependent receptor
AVL56_RS11365	COG0668	transmembrane transport
AVL56_RS11385	COG0668	transmembrane transport
AVL56_RS11405	COG0246	Mannitol dehydrogenase
AVL56_RS11415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVL56_RS11420	COG2390	Transcriptional regulator
AVL56_RS11430	COG0596	Alpha beta hydrolase
AVL56_RS11435	COG1960	acyl-CoA dehydrogenase activity
AVL56_RS11440	COG0183	Belongs to the thiolase family
AVL56_RS11445	COG1024	Enoyl-CoA hydratase
AVL56_RS11445	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVL56_RS11450	COG0596	Alpha beta hydrolase
AVL56_RS11480	COG1960	acyl-CoA dehydrogenase activity
AVL56_RS11490	COG4771	TonB-dependent receptor
AVL56_RS11510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AVL56_RS11530	COG0314	molybdopterin synthase activity
AVL56_RS11535	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AVL56_RS11540	COG0315	cyclic pyranopterin monophosphate synthase activity
AVL56_RS11545	COG0521	Mo-molybdopterin cofactor biosynthetic process
AVL56_RS11550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AVL56_RS11675	COG1028	Short-chain dehydrogenase reductase Sdr
AVL56_RS11710	COG0436	Aminotransferase
AVL56_RS11715	COG3268	Saccharopine dehydrogenase
AVL56_RS11730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVL56_RS11745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AVL56_RS11750	COG1074	ATP-dependent DNA helicase activity
AVL56_RS11755	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AVL56_RS11765	COG1022	Amp-dependent synthetase and ligase
AVL56_RS11770	COG3300	MHYT domain
AVL56_RS11770	COG5001	Diguanylate cyclase
AVL56_RS11780	COG3132	Protein of unknown function, DUF480
AVL56_RS11795	COG0583	DNA-binding transcription factor activity
AVL56_RS11815	COG0640	Transcriptional regulator
AVL56_RS11825	COG0583	DNA-binding transcription factor activity
AVL56_RS11835	COG2204	response regulator
AVL56_RS11845	COG4251	negative regulation of phosphorylation
AVL56_RS11850	COG0784	Response regulator, receiver
AVL56_RS11855	COG0784	Response regulator, receiver
AVL56_RS11855	COG2205	protein histidine kinase activity
AVL56_RS11880	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AVL56_RS11905	COG3139	Protein of unknown function (DUF1315)
AVL56_RS11915	COG1115	amino acid carrier protein
AVL56_RS11920	COG2866	Carboxypeptidase
AVL56_RS11940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AVL56_RS11950	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AVL56_RS11955	COG1640	4-alpha-glucanotransferase
AVL56_RS11965	COG0676	glucose-6-phosphate 1-epimerase activity
AVL56_RS11970	COG0800	Aldolase
AVL56_RS11980	COG0129	dihydroxy-acid dehydratase activity
AVL56_RS11990	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AVL56_RS11995	COG1737	Transcriptional regulator
AVL56_RS12000	COG0469	pyruvate kinase activity
AVL56_RS12005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AVL56_RS12050	COG2205	protein histidine kinase activity
AVL56_RS12055	COG0745	RESPONSE REGULATOR receiver
AVL56_RS12080	COG3665	Urea carboxylase-associated protein
AVL56_RS12090	COG1028	Short-chain dehydrogenase reductase Sdr
AVL56_RS12095	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AVL56_RS12120	COG2721	sulfolactate sulfo-lyase activity
AVL56_RS12125	COG1904	glucuronate isomerase
AVL56_RS12130	COG0246	Mannitol dehydrogenase
AVL56_RS12135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVL56_RS12140	COG2755	lipolytic protein G-D-S-L family
AVL56_RS12150	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AVL56_RS12160	COG4677	pectinesterase activity
AVL56_RS12180	COG2356	endonuclease I
AVL56_RS12190	COG1024	Enoyl-CoA hydratase
AVL56_RS12210	COG1609	Transcriptional regulator
AVL56_RS12215	COG4948	Mandelate Racemase Muconate Lactonizing
AVL56_RS12220	COG0673	inositol 2-dehydrogenase activity
AVL56_RS12235	COG5001	Diguanylate cyclase
AVL56_RS12235	COG3300	MHYT domain
AVL56_RS12250	COG0746	molybdenum cofactor guanylyltransferase activity
AVL56_RS12260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVL56_RS12265	COG1764	response to oxidative stress
AVL56_RS12290	COG0745	RESPONSE REGULATOR receiver
AVL56_RS12295	COG3850	Histidine kinase
AVL56_RS12295	COG5002	protein histidine kinase activity
AVL56_RS12330	COG0738	Major facilitator superfamily
AVL56_RS12355	COG0840	transmembrane signaling receptor activity
AVL56_RS12365	COG0753	catalase activity
AVL56_RS12375	COG0330	HflC and HflK could
AVL56_RS12395	COG0778	Nitroreductase
AVL56_RS12415	COG0471	metal ion transport
AVL56_RS12425	COG0489	protein tyrosine kinase activity
AVL56_RS12430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVL56_RS12430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVL56_RS12435	COG2226	methyltransferase
AVL56_RS12440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVL56_RS12445	COG1388	LysM domain
AVL56_RS12445	COG0741	lytic transglycosylase activity
AVL56_RS12465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AVL56_RS12470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVL56_RS12480	COG2268	Band 7 protein
AVL56_RS12500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVL56_RS12505	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVL56_RS12510	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AVL56_RS12515	COG2080	2 iron, 2 sulfur cluster binding
AVL56_RS12525	COG0604	alcohol dehydrogenase
AVL56_RS12535	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AVL56_RS12550	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AVL56_RS12555	COG1286	toxin biosynthetic process
AVL56_RS12560	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AVL56_RS12565	COG0285	dihydrofolate synthase activity
AVL56_RS12575	COG0101	tRNA pseudouridine synthase activity
AVL56_RS12590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVL56_RS12610	COG3706	GGDEF domain
AVL56_RS12615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVL56_RS12615	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AVL56_RS12645	COG3101	peptidyl-lysine hydroxylation
AVL56_RS12690	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVL56_RS12690	COG1902	pentaerythritol trinitrate reductase activity
AVL56_RS12715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL56_RS12720	COG1309	transcriptional regulator
AVL56_RS12725	COG4399	Belongs to the UPF0754 family
AVL56_RS12770	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AVL56_RS12775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVL56_RS12780	COG2983	Belongs to the UPF0260 family
AVL56_RS12785	COG0179	Fumarylacetoacetate (FAA) hydrolase
AVL56_RS12800	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AVL56_RS12805	COG0318	PFAM AMP-dependent synthetase and ligase
AVL56_RS12810	COG2267	carboxylic ester hydrolase activity
AVL56_RS12825	COG1214	PFAM Peptidase M22, glycoprotease
AVL56_RS12830	COG1199	ATP-dependent helicase activity
AVL56_RS12890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AVL56_RS12895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AVL56_RS12900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVL56_RS12905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AVL56_RS12905	COG0131	Imidazoleglycerol-phosphate dehydratase
AVL56_RS12910	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AVL56_RS12925	COG0140	phosphoribosyl-ATP diphosphatase activity
AVL56_RS12925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AVL56_RS12935	COG1028	Short-chain dehydrogenase reductase Sdr
AVL56_RS12945	COG1022	Amp-dependent synthetase and ligase
AVL56_RS12965	COG0463	Glycosyl transferase, family 2
AVL56_RS12985	COG0642	Histidine kinase
AVL56_RS12995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVL56_RS13020	COG0326	Molecular chaperone. Has ATPase activity
AVL56_RS13025	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AVL56_RS13050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AVL56_RS13055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AVL56_RS13065	COG3220	belongs to the UPF0276 family
AVL56_RS13075	COG2319	Wd-40 repeat
AVL56_RS13075	COG4249	Peptidase C14 caspase catalytic subunit p20
AVL56_RS13085	COG2203	Gaf domain
AVL56_RS13085	COG3706	GGDEF domain
AVL56_RS13085	COG4251	negative regulation of phosphorylation
AVL56_RS13085	COG5001	Diguanylate cyclase
AVL56_RS13120	COG1183	phosphatidylcholine synthase activity
AVL56_RS13140	COG0542	response to heat
AVL56_RS13145	COG1496	oxidoreductase activity
AVL56_RS13150	COG0564	pseudouridine synthase activity
AVL56_RS13165	COG1595	DNA-templated transcription, initiation
AVL56_RS13180	COG4221	oxidoreductase activity
AVL56_RS13185	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AVL56_RS13195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AVL56_RS13205	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AVL56_RS13210	COG1722	exodeoxyribonuclease VII activity
AVL56_RS13215	COG0142	geranyltranstransferase activity
AVL56_RS13225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AVL56_RS13230	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AVL56_RS13240	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AVL56_RS13255	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVL56_RS13255	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVL56_RS13270	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVL56_RS13275	COG0488	(ABC) transporter
AVL56_RS13285	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AVL56_RS13295	COG0560	Phosphoserine phosphatase
AVL56_RS13305	COG0084	hydrolase, TatD family'
AVL56_RS13350	COG1595	DNA-templated transcription, initiation
AVL56_RS13355	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AVL56_RS13370	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AVL56_RS13390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AVL56_RS13450	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AVL56_RS13455	COG1047	Peptidyl-prolyl cis-trans
AVL56_RS13465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AVL56_RS13470	COG0196	riboflavin kinase activity
AVL56_RS13475	COG0728	peptidoglycan biosynthetic process
AVL56_RS13480	COG0268	Binds directly to 16S ribosomal RNA
AVL56_RS13500	COG0385	Bile acid
AVL56_RS13530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVL56_RS13535	COG0776	regulation of translation
AVL56_RS13540	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AVL56_RS13545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AVL56_RS13550	COG0740	serine-type endopeptidase activity
AVL56_RS13555	COG0544	peptidyl-prolyl cis-trans isomerase activity
AVL56_RS13595	COG1720	tRNA m6t6A37 methyltransferase activity
AVL56_RS13615	COG0123	including yeast histone deacetylase and acetoin utilization protein
AVL56_RS13635	COG0517	IMP dehydrogenase activity
AVL56_RS13635	COG0516	GMP reductase activity
AVL56_RS13640	COG1570	exodeoxyribonuclease VII activity
AVL56_RS13655	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVL56_RS13660	COG2976	Protein conserved in bacteria
AVL56_RS13685	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AVL56_RS13695	COG2166	iron-sulfur cluster assembly
AVL56_RS13710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVL56_RS13715	COG0719	Fe-S assembly protein
AVL56_RS13720	COG0396	ATPase activity
AVL56_RS13725	COG0719	Fe-S assembly protein
AVL56_RS13730	COG1104	cysteine desulfurase activity
AVL56_RS13745	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AVL56_RS13750	COG0483	inositol monophosphate 1-phosphatase activity
AVL56_RS13780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVL56_RS13785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVL56_RS13790	COG1862	Preprotein translocase
AVL56_RS13795	COG0343	queuine tRNA-ribosyltransferase activity
AVL56_RS13810	COG3789	protein conserved in bacteria
AVL56_RS13815	COG1842	Phage shock protein A
AVL56_RS13840	COG0754	glutathionylspermidine amidase activity
AVL56_RS13855	COG2066	Belongs to the glutaminase family
AVL56_RS13860	COG1785	Belongs to the alkaline phosphatase family
AVL56_RS13865	COG0745	RESPONSE REGULATOR receiver
AVL56_RS13915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AVL56_RS13920	COG1045	serine acetyltransferase
AVL56_RS13945	COG0438	transferase activity, transferring glycosyl groups
AVL56_RS13990	COG1216	Glycosyl transferase, family 2
AVL56_RS13990	COG0463	Glycosyl transferase, family 2
AVL56_RS14025	COG0489	protein tyrosine kinase activity
AVL56_RS14035	COG3267	Type II secretory pathway component ExeA
AVL56_RS14035	COG3409	Peptidoglycan-binding domain 1 protein
AVL56_RS14040	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AVL56_RS14040	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AVL56_RS14045	COG2827	Endonuclease containing a URI domain
AVL56_RS14065	COG1560	Kdo2-lipid A biosynthetic process
AVL56_RS14095	COG1960	acyl-CoA dehydrogenase activity
AVL56_RS14110	COG1435	thymidine kinase activity
AVL56_RS14120	COG1609	Transcriptional regulator
AVL56_RS14125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AVL56_RS14165	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AVL56_RS14170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVL56_RS14175	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AVL56_RS14180	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AVL56_RS14205	COG2815	serine threonine protein kinase
AVL56_RS14205	COG0515	serine threonine protein kinase
AVL56_RS14215	COG1982	Orn Lys Arg decarboxylase major
AVL56_RS14235	COG4774	siderophore transport
AVL56_RS14250	COG1028	Short-chain dehydrogenase reductase Sdr
AVL56_RS14255	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AVL56_RS14260	COG0789	Transcriptional regulator
AVL56_RS14275	COG0189	ligase activity
AVL56_RS14330	COG1960	acyl-CoA dehydrogenase activity
AVL56_RS14360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AVL56_RS14370	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AVL56_RS14420	COG1607	acyl-coa hydrolase
AVL56_RS14425	COG0826	peptidase U32
AVL56_RS14500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AVL56_RS14540	COG1028	Short-chain dehydrogenase reductase Sdr
AVL56_RS14550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AVL56_RS14555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVL56_RS14560	COG1845	cytochrome c oxidase, subunit III
AVL56_RS14570	COG0109	protoheme IX farnesyltransferase activity
AVL56_RS14585	COG0583	DNA-binding transcription factor activity
AVL56_RS14600	COG4221	oxidoreductase activity
AVL56_RS14605	COG0693	protein deglycase activity
AVL56_RS14635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AVL56_RS14640	COG1335	isochorismatase
AVL56_RS14645	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AVL56_RS14700	COG1566	PFAM secretion protein HlyD family protein
AVL56_RS14705	COG1846	Transcriptional regulator
AVL56_RS14715	COG1295	ribonuclease BN
AVL56_RS14720	COG0514	ATP-dependent DNA helicase (RecQ)
AVL56_RS14745	COG0583	DNA-binding transcription factor activity
AVL56_RS14755	COG0484	heat shock protein binding
AVL56_RS14780	COG2319	Wd-40 repeat
AVL56_RS14780	COG4249	Peptidase C14 caspase catalytic subunit p20
AVL56_RS14795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVL56_RS14815	COG1451	nucleotide metabolic process
AVL56_RS14830	COG0653	protein targeting
AVL56_RS14845	COG1757	Na H antiporter
AVL56_RS14865	COG2133	pyrroloquinoline quinone binding
AVL56_RS14875	COG0697	spore germination
AVL56_RS14880	COG3813	Protein conserved in bacteria
AVL56_RS14885	COG0513	Belongs to the DEAD box helicase family
AVL56_RS14935	COG2814	Major facilitator Superfamily
AVL56_RS14945	COG0656	L-ascorbic acid biosynthetic process
AVL56_RS14985	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVL56_RS14985	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVL56_RS15000	COG0583	DNA-binding transcription factor activity
AVL56_RS15015	COG1621	beta-fructofuranosidase activity
AVL56_RS15020	COG0477	Major facilitator Superfamily
AVL56_RS15030	COG1629	transport
AVL56_RS15055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVL56_RS15060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVL56_RS15065	COG0006	proline dipeptidase activity
AVL56_RS15080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVL56_RS15095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AVL56_RS15100	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AVL56_RS15105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVL56_RS15125	COG3313	Fe-S protein
AVL56_RS15165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVL56_RS15170	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVL56_RS15175	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AVL56_RS15210	COG1459	type II secretion system
AVL56_RS15220	COG0237	dephospho-CoA kinase activity
AVL56_RS15220	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AVL56_RS15225	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AVL56_RS15230	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AVL56_RS15235	COG2988	succinylglutamate desuccinylase activity
AVL56_RS15240	COG0494	nUDIX hydrolase
AVL56_RS15250	COG0739	heme binding
AVL56_RS15255	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AVL56_RS15265	COG0849	cell division
AVL56_RS15270	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AVL56_RS15275	COG1181	Belongs to the D-alanine--D-alanine ligase family
AVL56_RS15280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AVL56_RS15290	COG0772	Belongs to the SEDS family
AVL56_RS15295	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AVL56_RS15305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AVL56_RS15310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVL56_RS15315	COG0768	penicillin binding
AVL56_RS15320	COG3116	cell division
AVL56_RS15330	COG2001	Belongs to the MraZ family
AVL56_RS15370	COG0678	peroxiredoxin activity
AVL56_RS15370	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AVL56_RS15390	COG2198	Histidine kinase
AVL56_RS15390	COG0784	Response regulator, receiver
AVL56_RS15390	COG5002	protein histidine kinase activity
AVL56_RS15410	COG0668	transmembrane transport
AVL56_RS15415	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AVL56_RS15420	COG0189	ligase activity
AVL56_RS15425	COG1678	Uncharacterized ACR, COG1678
AVL56_RS15430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AVL56_RS15450	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AVL56_RS15455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AVL56_RS15460	COG0762	integral membrane protein
AVL56_RS15475	COG1902	pentaerythritol trinitrate reductase activity
AVL56_RS15475	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVL56_RS15490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVL56_RS15495	COG0625	glutathione transferase activity
AVL56_RS15525	COG0083	homoserine kinase activity
AVL56_RS15535	COG0583	DNA-binding transcription factor activity
AVL56_RS15545	COG2197	response regulator
AVL56_RS15550	COG4585	Histidine kinase
AVL56_RS15570	COG0640	Transcriptional regulator
AVL56_RS15580	COG0431	NADPH-dependent FMN reductase
AVL56_RS15585	COG0798	PFAM Bile acid sodium symporter
AVL56_RS15590	COG2201	protein-glutamate methylesterase activity
AVL56_RS15595	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AVL56_RS15600	COG0745	RESPONSE REGULATOR receiver
AVL56_RS15605	COG5002	protein histidine kinase activity
AVL56_RS15630	COG1748	Saccharopine dehydrogenase
AVL56_RS15645	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AVL56_RS15650	COG3107	peptidoglycan biosynthetic process
AVL56_RS15655	COG0792	nuclease activity
AVL56_RS15665	COG2823	Periplasmic or secreted lipoprotein
AVL56_RS15685	COG0583	DNA-binding transcription factor activity
AVL56_RS15700	COG4585	Histidine kinase
AVL56_RS15705	COG2197	response regulator
AVL56_RS15710	COG4771	TonB-dependent receptor
AVL56_RS15720	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AVL56_RS15725	COG0372	Belongs to the citrate synthase family
AVL56_RS15735	COG2828	Protein conserved in bacteria
AVL56_RS15740	COG2203	Gaf domain
AVL56_RS15740	COG2199	diguanylate cyclase activity
AVL56_RS15760	COG4206	TonB-dependent receptor
AVL56_RS15765	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AVL56_RS15785	COG0784	Response regulator, receiver
AVL56_RS15785	COG5002	protein histidine kinase activity
AVL56_RS15785	COG2198	Histidine kinase
AVL56_RS15790	COG0069	glutamate synthase activity
AVL56_RS15790	COG0070	glutamate synthase
AVL56_RS15790	COG0067	glutamate synthase
AVL56_RS15795	COG0493	'glutamate synthase
AVL56_RS15805	COG1476	TRANSCRIPTIONal
AVL56_RS15820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AVL56_RS15830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVL56_RS15835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVL56_RS15850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AVL56_RS15855	COG0739	heme binding
AVL56_RS15860	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AVL56_RS15870	COG0738	Major facilitator superfamily
AVL56_RS15880	COG1902	pentaerythritol trinitrate reductase activity
AVL56_RS15890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVL56_RS15895	COG0625	glutathione transferase activity
AVL56_RS15915	COG2894	cell division
AVL56_RS15920	COG0850	regulation of cytokinetic process
AVL56_RS15945	COG1981	membrane
AVL56_RS15960	COG1914	H( )-stimulated, divalent metal cation uptake system
AVL56_RS15965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AVL56_RS15980	COG1217	gtp-binding protein TYPA
AVL56_RS15985	COG0174	glutamine synthetase
AVL56_RS15995	COG3852	Histidine kinase
AVL56_RS16005	COG3437	response regulator, receiver
AVL56_RS16025	COG3706	GGDEF domain
AVL56_RS16040	COG0525	valine-tRNA ligase activity
AVL56_RS16045	COG2927	DNA polymerase III (CHI subunit)
AVL56_RS16050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AVL56_RS16055	COG0795	lipopolysaccharide-transporting ATPase activity
AVL56_RS16060	COG0795	lipopolysaccharide-transporting ATPase activity
AVL56_RS16125	COG1082	Xylose isomerase domain protein TIM barrel
AVL56_RS16165	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AVL56_RS16180	COG0251	oxidation-reduction process
AVL56_RS16235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVL56_RS16245	COG0395	ABC-type sugar transport system, permease component
AVL56_RS16265	COG3706	GGDEF domain
AVL56_RS16270	COG3706	GGDEF domain
AVL56_RS16300	COG4771	TonB-dependent receptor
AVL56_RS16305	COG1858	cytochrome C peroxidase
AVL56_RS16335	COG1028	Short-chain dehydrogenase reductase Sdr
AVL56_RS16345	COG1917	Cupin 2, conserved barrel domain protein
AVL56_RS16350	COG2271	Major facilitator Superfamily
AVL56_RS16370	COG1716	ATPase activity
AVL56_RS16405	COG1357	PFAM Pentapeptide repeats (8 copies)
AVL56_RS16405	COG0515	serine threonine protein kinase
AVL56_RS16420	COG1716	ATPase activity
AVL56_RS16420	COG1131	(ABC) transporter
AVL56_RS16420	COG0842	Transport permease protein
AVL56_RS16425	COG0513	Belongs to the DEAD box helicase family
AVL56_RS16430	COG0800	Aldolase
AVL56_RS16435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVL56_RS16440	COG2186	Transcriptional regulator
AVL56_RS16450	COG3264	Mechanosensitive ion channel
AVL56_RS16450	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AVL56_RS16485	COG3568	Endonuclease Exonuclease Phosphatase
AVL56_RS16500	COG0730	response to heat
AVL56_RS16505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVL56_RS16520	COG4191	Histidine kinase
AVL56_RS16530	COG0417	DNA replication proofreading
AVL56_RS16580	COG1309	transcriptional regulator
AVL56_RS16595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVL56_RS16605	COG1573	uracil-dna glycosylase
AVL56_RS16610	COG3300	MHYT domain
AVL56_RS16610	COG5001	Diguanylate cyclase
AVL56_RS16630	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AVL56_RS16635	COG4771	TonB-dependent receptor
AVL56_RS16660	COG1842	Phage shock protein A
AVL56_RS16670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AVL56_RS16695	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AVL56_RS16700	COG0204	Acyl-transferase
AVL56_RS16705	COG0204	Acyl-transferase
AVL56_RS16710	COG0668	transmembrane transport
AVL56_RS16725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVL56_RS16730	COG0733	neurotransmitter:sodium symporter activity
AVL56_RS16745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVL56_RS16770	COG0848	biopolymer transport protein
AVL56_RS16780	COG0457	Tetratricopeptide repeat
AVL56_RS16810	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AVL56_RS16815	COG0702	epimerase
AVL56_RS16830	COG5001	Diguanylate cyclase
AVL56_RS16830	COG5002	protein histidine kinase activity
AVL56_RS16840	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AVL56_RS16845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVL56_RS16855	COG0583	DNA-binding transcription factor activity
AVL56_RS16860	COG0121	glutamine amidotransferase
AVL56_RS16875	COG1522	sequence-specific DNA binding
AVL56_RS16890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVL56_RS16900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AVL56_RS16910	COG1477	protein flavinylation
AVL56_RS16915	COG2871	sodium ion transport
AVL56_RS16920	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AVL56_RS16925	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AVL56_RS16930	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AVL56_RS16935	COG1805	sodium ion transport
AVL56_RS16940	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AVL56_RS16945	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AVL56_RS16950	COG0545	Peptidyl-prolyl cis-trans isomerase
AVL56_RS16955	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AVL56_RS16965	COG0039	L-malate dehydrogenase activity
AVL56_RS16970	COG1438	arginine binding
AVL56_RS17000	COG0572	uridine kinase
AVL56_RS17005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AVL56_RS17015	COG0457	Tetratricopeptide repeat
AVL56_RS17020	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AVL56_RS17040	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AVL56_RS17040	COG0517	IMP dehydrogenase activity
AVL56_RS17045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVL56_RS17065	COG0189	ligase activity
AVL56_RS17075	COG0189	ligase activity
AVL56_RS17075	COG4067	protein conserved in archaea
AVL56_RS17090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVL56_RS17105	COG1283	sodium-dependent phosphate transmembrane transporter activity
AVL56_RS17110	COG0667	Aldo Keto reductase
AVL56_RS17125	COG0753	catalase activity
AVL56_RS17160	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AVL56_RS17165	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AVL56_RS17165	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AVL56_RS17170	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AVL56_RS17225	COG0583	DNA-binding transcription factor activity
AVL56_RS17280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AVL56_RS17295	COG1216	Glycosyl transferase, family 2
AVL56_RS17295	COG0438	transferase activity, transferring glycosyl groups
AVL56_RS17325	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AVL56_RS17340	COG3119	arylsulfatase activity
AVL56_RS17355	COG1216	Glycosyl transferase, family 2
AVL56_RS17355	COG0438	transferase activity, transferring glycosyl groups
AVL56_RS17360	COG0662	Cupin 2, conserved barrel domain protein
AVL56_RS17360	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AVL56_RS17370	COG0202	RNA polymerase activity
AVL56_RS17390	COG0201	protein transport
AVL56_RS17410	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AVL56_RS17445	COG5002	protein histidine kinase activity
AVL56_RS17445	COG0784	Response regulator, receiver
AVL56_RS17460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVL56_RS17465	COG0557	exoribonuclease II activity
AVL56_RS17480	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AVL56_RS17495	COG0543	2 iron, 2 sulfur cluster binding
AVL56_RS17500	COG2234	aminopeptidase activity
AVL56_RS17520	COG1271	oxidase subunit
AVL56_RS17525	COG1294	oxidase, subunit
AVL56_RS17530	COG0840	transmembrane signaling receptor activity
AVL56_RS17535	COG1522	sequence-specific DNA binding
AVL56_RS17550	COG1278	Cold shock
AVL56_RS17555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AVL56_RS17575	COG0339	signal peptide processing
AVL56_RS17580	COG2201	protein-glutamate methylesterase activity
AVL56_RS17590	COG4191	Histidine kinase
AVL56_RS17590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVL56_RS17600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVL56_RS17605	COG0243	molybdopterin cofactor binding
AVL56_RS17610	COG4946	Tricorn protease homolog
AVL56_RS17610	COG0793	Belongs to the peptidase S41A family
AVL56_RS17650	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AVL56_RS17655	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AVL56_RS17660	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AVL56_RS17675	COG0281	malic enzyme
AVL56_RS17680	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AVL56_RS17685	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AVL56_RS17715	COG0456	acetyltransferase
AVL56_RS17725	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AVL56_RS17730	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AVL56_RS17735	COG2177	Part of the ABC transporter FtsEX involved in
AVL56_RS17740	COG2884	Cell division ATP-binding protein ftsE
AVL56_RS17745	COG0552	protein localization to endoplasmic reticulum
AVL56_RS17750	COG0742	ribosomal rna small subunit methyltransferase
AVL56_RS17760	COG2095	MarC family integral membrane protein
AVL56_RS17780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AVL56_RS17785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVL56_RS17795	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AVL56_RS17810	COG0076	glutamate decarboxylase activity
AVL56_RS17815	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AVL56_RS17825	COG0842	Transport permease protein
AVL56_RS17830	COG1131	(ABC) transporter
AVL56_RS17835	COG0745	RESPONSE REGULATOR receiver
AVL56_RS17840	COG2205	protein histidine kinase activity
AVL56_RS17845	COG4774	siderophore transport
AVL56_RS17865	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AVL56_RS17870	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AVL56_RS17880	COG0535	radical SAM domain protein
AVL56_RS17895	COG1253	flavin adenine dinucleotide binding
AVL56_RS17900	COG0701	Predicted permease
AVL56_RS17905	COG1966	Carbon starvation protein
AVL56_RS17920	COG0657	acetylesterase activity
AVL56_RS17955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AVL56_RS17960	COG0049	tRNA binding
AVL56_RS17965	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AVL56_RS17970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AVL56_RS17975	COG0085	RNA polymerase activity
AVL56_RS17980	COG0222	ribosome binding
AVL56_RS17985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AVL56_RS17990	COG0081	regulation of translation
AVL56_RS17995	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AVL56_RS18000	COG0250	Participates in transcription elongation, termination and antitermination
AVL56_RS18005	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AVL56_RS18015	COG1132	(ABC) transporter
AVL56_RS18020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AVL56_RS18025	COG3590	peptidase
AVL56_RS18035	COG0513	Belongs to the DEAD box helicase family
AVL56_RS18040	COG0418	dihydroorotase activity
AVL56_RS18050	COG3040	lipid binding
AVL56_RS18055	COG4989	oxidoreductase activity
AVL56_RS18060	COG0346	lactoylglutathione lyase activity
AVL56_RS18075	COG0302	gtp cyclohydrolase
AVL56_RS18095	COG2957	Belongs to the agmatine deiminase family
AVL56_RS18100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVL56_RS18115	COG3306	glycosyltransferase involved in LPS biosynthesis
AVL56_RS18120	COG1201	RNA secondary structure unwinding
AVL56_RS18130	COG1793	dna ligase
AVL56_RS18140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVL56_RS18155	COG0625	glutathione transferase activity
AVL56_RS18170	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AVL56_RS18175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVL56_RS18185	COG1012	belongs to the aldehyde dehydrogenase family
AVL56_RS18200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVL56_RS18205	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AVL56_RS18210	COG0330	HflC and HflK could
AVL56_RS18215	COG0330	HflC and HflK could
AVL56_RS18220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AVL56_RS18225	COG1923	regulation of RNA biosynthetic process
AVL56_RS18230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AVL56_RS18245	COG0802	atpase or kinase
AVL56_RS18250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AVL56_RS18250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AVL56_RS18255	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AVL56_RS18270	COG2816	NAD+ diphosphatase activity
AVL56_RS18275	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AVL56_RS18280	COG0735	belongs to the Fur family
AVL56_RS18300	COG0305	Participates in initiation and elongation during chromosome replication
AVL56_RS18325	COG2258	MOSC domain
AVL56_RS18355	COG5002	protein histidine kinase activity
AVL56_RS18365	COG0840	transmembrane signaling receptor activity
AVL56_RS18370	COG4191	Histidine kinase
AVL56_RS18370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVL56_RS18380	COG1609	Transcriptional regulator
AVL56_RS18385	COG2211	Major facilitator Superfamily
AVL56_RS18390	COG2723	6-phospho-beta-galactosidase activity
AVL56_RS18400	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AVL56_RS18405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVL56_RS18410	COG4558	Periplasmic binding protein
AVL56_RS18420	COG4206	TonB-dependent receptor
AVL56_RS18430	COG1472	Belongs to the glycosyl hydrolase 3 family
AVL56_RS18445	COG2855	membrane
AVL56_RS18450	COG2175	clavaminate synthase activity
AVL56_RS18455	COG0656	L-ascorbic acid biosynthetic process
AVL56_RS18460	COG2188	Transcriptional regulator
AVL56_RS18475	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVL56_RS18480	COG1230	cation diffusion facilitator family transporter
AVL56_RS18515	COG4771	TonB-dependent receptor
AVL56_RS18520	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AVL56_RS18525	COG4988	ABC transporter
AVL56_RS18535	COG1294	oxidase, subunit
AVL56_RS18550	COG2204	response regulator
AVL56_RS18585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AVL56_RS18615	COG4319	ketosteroid isomerase
AVL56_RS18655	COG3237	CsbD-like
AVL56_RS18675	COG1404	Belongs to the peptidase S8 family
AVL56_RS18700	COG2267	carboxylic ester hydrolase activity
AVL56_RS18725	COG3038	cytochrome b561
AVL56_RS18730	COG2353	YceI-like domain
AVL56_RS18735	COG1252	NADH dehydrogenase
AVL56_RS18765	COG2130	NADP-dependent
AVL56_RS18770	COG5001	Diguanylate cyclase
AVL56_RS18770	COG4251	negative regulation of phosphorylation
AVL56_RS18770	COG3706	GGDEF domain
AVL56_RS18770	COG2203	Gaf domain
AVL56_RS18790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL56_RS18800	COG4181	ATPase activity
AVL56_RS18820	COG0523	cobalamin synthesis protein
AVL56_RS18835	COG4771	TonB-dependent receptor
AVL56_RS18865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AVL56_RS18870	COG1349	DNA-binding transcription factor activity
AVL56_RS18885	COG0697	spore germination
AVL56_RS18890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AVL56_RS18895	COG4977	sequence-specific DNA binding
AVL56_RS18915	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AVL56_RS18935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVL56_RS18945	COG0523	cobalamin synthesis protein
AVL56_RS18975	COG4232	protein-disulfide reductase activity
AVL56_RS18980	COG0739	heme binding
AVL56_RS18985	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AVL56_RS18990	COG0511	ligase activity, forming carbon-carbon bonds
AVL56_RS18995	COG0439	Biotin carboxylase
AVL56_RS19015	COG2176	DNA-directed DNA polymerase activity
AVL56_RS19035	COG0154	amidase activity
AVL56_RS19050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AVL56_RS19055	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AVL56_RS19070	COG0151	Belongs to the GarS family
AVL56_RS19080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVL56_RS19090	COG3954	Phosphoribulokinase
AVL56_RS19095	COG2233	PERMEase
AVL56_RS19130	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AVL56_RS19135	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AVL56_RS19145	COG3031	protein transport across the cell outer membrane
AVL56_RS19155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AVL56_RS19160	COG1459	type II secretion system
AVL56_RS19165	COG2165	general secretion pathway protein
AVL56_RS19175	COG2165	general secretion pathway protein
AVL56_RS19180	COG4795	General secretion pathway protein
AVL56_RS19195	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AVL56_RS19205	COG1234	tRNA 3'-trailer cleavage
AVL56_RS19210	COG1012	belongs to the aldehyde dehydrogenase family
AVL56_RS19220	COG1011	Hydrolase
AVL56_RS19225	COG0494	nUDIX hydrolase
AVL56_RS19230	COG1218	3'(2'),5'-bisphosphate nucleotidase
AVL56_RS19240	COG2943	transferase activity, transferring hexosyl groups
AVL56_RS19245	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AVL56_RS19255	COG3089	Belongs to the UPF0270 family
AVL56_RS19260	COG0429	hydrolase of the alpha beta-hydrolase fold
AVL56_RS19270	COG0488	(ABC) transporter
AVL56_RS19295	COG0545	Peptidyl-prolyl cis-trans isomerase
AVL56_RS19305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AVL56_RS19310	COG2183	response to ionizing radiation
AVL56_RS19325	COG0596	Alpha beta hydrolase
AVL56_RS19330	COG1040	competence protein
AVL56_RS19350	COG1794	racemase activity, acting on amino acids and derivatives
AVL56_RS19365	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AVL56_RS19370	COG0534	Mate efflux family protein
AVL56_RS19385	COG1999	signal sequence binding
AVL56_RS19390	COG0109	protoheme IX farnesyltransferase activity
AVL56_RS19395	COG1612	heme a metabolic process
AVL56_RS19420	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AVL56_RS19425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVL56_RS19430	COG1565	acr, cog1565
AVL56_RS19430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AVL56_RS19440	COG4974	Belongs to the 'phage' integrase family
AVL56_RS19475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVL56_RS19485	COG0786	glutamate:sodium symporter activity
AVL56_RS19545	COG0129	dihydroxy-acid dehydratase activity
AVL56_RS19560	COG0606	chelatase, subunit chli
AVL56_RS19575	COG2814	Major facilitator Superfamily
AVL56_RS19585	COG0729	surface antigen
AVL56_RS19590	COG2911	Protein conserved in bacteria
AVL56_RS19615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVL56_RS19625	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AVL56_RS19645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AVL56_RS19695	COG0425	Belongs to the sulfur carrier protein TusA family
AVL56_RS19710	COG1561	YicC-like family, N-terminal region
AVL56_RS19745	COG2211	Major facilitator Superfamily
AVL56_RS19750	COG1609	Transcriptional regulator
AVL56_RS19765	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AVL56_RS19765	COG2199	diguanylate cyclase activity
AVL56_RS19795	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AVL56_RS19815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AVL56_RS19820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AVL56_RS19840	COG1475	DNA binding
AVL56_RS19845	COG1192	Involved in chromosome partitioning
AVL56_RS19870	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AVL56_RS19875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AVL56_RS19885	COG0706	membrane insertase activity
AVL56_RS19890	COG0594	ribonuclease P activity
AVL56_RS19895	COG0230	Belongs to the bacterial ribosomal protein bL34 family