locus-tag	class	description
EP12_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EP12_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EP12_RS00040	COG2818	Glycosylase
EP12_RS00050	COG3078	GTPase activator activity
EP12_RS00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EP12_RS00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EP12_RS00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EP12_RS00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EP12_RS00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EP12_RS00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EP12_RS00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EP12_RS00105	COG1652	LysM domain
EP12_RS00110	COG0758	DNA mediated transformation
EP12_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
EP12_RS00130	COG0408	coproporphyrinogen oxidase activity
EP12_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EP12_RS00230	COG2234	aminopeptidase activity
EP12_RS00235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EP12_RS00255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EP12_RS00280	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP12_RS00310	COG3642	lipopolysaccharide core region biosynthetic process
EP12_RS00315	COG0859	PFAM glycosyl transferase family 9
EP12_RS00335	COG0156	8-amino-7-oxononanoate synthase activity
EP12_RS00345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP12_RS00350	COG0705	Rhomboid family
EP12_RS00360	COG3161	chorismate lyase activity
EP12_RS00365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EP12_RS00370	COG2960	long-chain fatty acid transporting porin activity
EP12_RS00375	COG0210	DNA helicase
EP12_RS00425	COG0842	Transport permease protein
EP12_RS00425	COG1129	ABC transporter
EP12_RS00430	COG0842	Transport permease protein
EP12_RS00435	COG4773	Receptor
EP12_RS00440	COG4771	TonB-dependent receptor
EP12_RS00445	COG1960	acyl-CoA dehydrogenase activity
EP12_RS00450	COG0583	DNA-binding transcription factor activity
EP12_RS00460	COG3106	COG3106 Predicted ATPase
EP12_RS00475	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EP12_RS00495	COG0352	thiamine-phosphate diphosphorylase activity
EP12_RS00505	COG4771	TonB-dependent receptor
EP12_RS00520	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
EP12_RS00520	COG0778	Nitroreductase
EP12_RS00530	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EP12_RS00535	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EP12_RS00540	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EP12_RS00545	COG1309	transcriptional regulator
EP12_RS00570	COG1953	Uracil, thiamine, allantoin
EP12_RS00585	COG2959	enzyme of heme biosynthesis
EP12_RS00590	COG1587	Uroporphyrinogen-III synthase
EP12_RS00595	COG0181	hydroxymethylbilane synthase activity
EP12_RS00610	COG0194	GDP metabolic process
EP12_RS00620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP12_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP12_RS00635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EP12_RS00645	COG0678	peroxiredoxin activity
EP12_RS00660	COG1178	ABC-type Fe3 transport system permease component
EP12_RS00665	COG3842	ATPase activity
EP12_RS00670	COG0668	transmembrane transport
EP12_RS00675	COG2081	HI0933 family
EP12_RS00685	COG4774	siderophore transport
EP12_RS00700	COG0745	RESPONSE REGULATOR receiver
EP12_RS00705	COG0457	Tetratricopeptide repeat
EP12_RS00730	COG0010	Belongs to the arginase family
EP12_RS00735	COG0010	Belongs to the arginase family
EP12_RS00740	COG0784	Response regulator, receiver
EP12_RS00740	COG2198	Histidine kinase
EP12_RS00740	COG5002	protein histidine kinase activity
EP12_RS00755	COG1172	Belongs to the binding-protein-dependent transport system permease family
EP12_RS00770	COG0829	nickel cation binding
EP12_RS00775	COG0831	urea catabolic process
EP12_RS00795	COG0830	nickel cation binding
EP12_RS00845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP12_RS00860	COG0427	acetyl-CoA hydrolase
EP12_RS00865	COG0123	including yeast histone deacetylase and acetoin utilization protein
EP12_RS00890	COG3064	Membrane
EP12_RS00900	COG5001	Diguanylate cyclase
EP12_RS00900	COG5002	protein histidine kinase activity
EP12_RS00915	COG0514	ATP-dependent DNA helicase (RecQ)
EP12_RS00925	COG2239	Acts as a magnesium transporter
EP12_RS00930	COG2962	Rard protein
EP12_RS00940	COG0210	DNA helicase
EP12_RS00950	COG1011	Hydrolase
EP12_RS00970	COG0019	diaminopimelate decarboxylase activity
EP12_RS01000	COG0163	prenyltransferase activity
EP12_RS01005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EP12_RS01015	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EP12_RS01040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EP12_RS01045	COG2814	Major facilitator Superfamily
EP12_RS01050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP12_RS01080	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EP12_RS01115	COG2801	Transposase and inactivated derivatives
EP12_RS01120	COG2801	Transposase and inactivated derivatives
EP12_RS01150	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EP12_RS01185	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP12_RS01220	COG1077	Cell shape determining protein MreB Mrl
EP12_RS01225	COG1792	Involved in formation and maintenance of cell shape
EP12_RS01230	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EP12_RS01235	COG0424	maF-like protein
EP12_RS01240	COG1530	ribonuclease E activity
EP12_RS01255	COG0312	modulator of DNA gyrase
EP12_RS01260	COG3028	Belongs to the UPF0307 family
EP12_RS01265	COG0312	modulator of DNA gyrase
EP12_RS01280	COG0745	RESPONSE REGULATOR receiver
EP12_RS01285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP12_RS01285	COG4191	Histidine kinase
EP12_RS01300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EP12_RS01305	COG0148	phosphopyruvate hydratase activity
EP12_RS01340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EP12_RS01355	COG0732	type I restriction modification DNA specificity domain
EP12_RS01360	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EP12_RS01410	COG4974	Belongs to the 'phage' integrase family
EP12_RS01475	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EP12_RS01485	COG0463	Glycosyl transferase, family 2
EP12_RS01495	COG0745	RESPONSE REGULATOR receiver
EP12_RS01540	COG0789	Transcriptional regulator
EP12_RS01545	COG2217	Heavy metal translocating P-type atpase
EP12_RS01580	COG0531	amino acid
EP12_RS01590	COG2132	Multicopper oxidase
EP12_RS01690	COG0583	DNA-binding transcription factor activity
EP12_RS01695	COG2814	Major facilitator Superfamily
EP12_RS01700	COG0840	transmembrane signaling receptor activity
EP12_RS01705	COG0745	RESPONSE REGULATOR receiver
EP12_RS01710	COG0643	Histidine kinase
EP12_RS01710	COG2198	Histidine kinase
EP12_RS01715	COG0835	chemotaxis
EP12_RS01730	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EP12_RS01760	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EP12_RS01820	COG4989	oxidoreductase activity
EP12_RS01825	COG3040	lipid binding
EP12_RS01840	COG0513	Belongs to the DEAD box helicase family
EP12_RS01850	COG3590	peptidase
EP12_RS01855	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EP12_RS01865	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EP12_RS01870	COG1132	(ABC) transporter
EP12_RS01880	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EP12_RS01885	COG0250	Participates in transcription elongation, termination and antitermination
EP12_RS01900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EP12_RS01905	COG0081	regulation of translation
EP12_RS01910	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EP12_RS01915	COG0222	ribosome binding
EP12_RS01920	COG0085	RNA polymerase activity
EP12_RS01925	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EP12_RS01930	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EP12_RS01935	COG0049	tRNA binding
EP12_RS01985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EP12_RS01990	COG0051	transcription antitermination factor activity, RNA binding
EP12_RS02005	COG0089	rRNA binding
EP12_RS02015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EP12_RS02025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EP12_RS02040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EP12_RS02045	COG0438	transferase activity, transferring glycosyl groups
EP12_RS02090	COG0788	formyltetrahydrofolate deformylase activity
EP12_RS02110	COG2951	lytic endotransglycosylase activity
EP12_RS02120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EP12_RS02135	COG2169	Transcriptional regulator
EP12_RS02155	COG0004	ammonium transporteR
EP12_RS02160	COG0405	Gamma-glutamyltransferase
EP12_RS02165	COG2837	iron assimilation
EP12_RS02210	COG5001	Diguanylate cyclase
EP12_RS02210	COG3300	MHYT domain
EP12_RS02230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EP12_RS02240	COG0512	Glutamine amidotransferase of anthranilate synthase
EP12_RS02245	COG0180	Tryptophanyl-tRNA synthetase
EP12_RS02250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EP12_RS02270	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EP12_RS02280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EP12_RS02315	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EP12_RS02320	COG0281	malic enzyme
EP12_RS02325	COG0625	glutathione transferase activity
EP12_RS02330	COG0753	catalase activity
EP12_RS02350	COG5001	Diguanylate cyclase
EP12_RS02350	COG3300	MHYT domain
EP12_RS02355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EP12_RS02355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EP12_RS02365	COG0137	argininosuccinate synthase activity
EP12_RS02385	COG1803	Methylglyoxal synthase
EP12_RS02410	COG0745	RESPONSE REGULATOR receiver
EP12_RS02420	COG2267	carboxylic ester hydrolase activity
EP12_RS02425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EP12_RS02435	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EP12_RS02445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EP12_RS02450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP12_RS02455	COG4942	peptidase
EP12_RS02465	COG2861	carbohydrate metabolic process
EP12_RS02490	COG1162	GTPase activity
EP12_RS02495	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EP12_RS02525	COG0028	Belongs to the TPP enzyme family
EP12_RS02545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EP12_RS02565	COG3706	GGDEF domain
EP12_RS02575	COG0248	Ppx GppA phosphatase
EP12_RS02580	COG0513	Belongs to the DEAD box helicase family
EP12_RS02585	COG3118	belongs to the thioredoxin family
EP12_RS02590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EP12_RS02595	COG1473	amidohydrolase
EP12_RS02600	COG0784	Response regulator, receiver
EP12_RS02600	COG2205	protein histidine kinase activity
EP12_RS02605	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EP12_RS02610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EP12_RS02615	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EP12_RS02630	COG0783	Belongs to the Dps family
EP12_RS02635	COG2133	pyrroloquinoline quinone binding
EP12_RS02650	COG3118	belongs to the thioredoxin family
EP12_RS02660	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EP12_RS02665	COG1012	belongs to the aldehyde dehydrogenase family
EP12_RS02675	COG1757	Na H antiporter
EP12_RS02690	COG3876	Protein conserved in bacteria
EP12_RS02795	COG0519	Catalyzes the synthesis of GMP from XMP
EP12_RS02835	COG1228	amidohydrolase
EP12_RS02865	COG0183	Belongs to the thiolase family
EP12_RS02870	COG1024	Enoyl-CoA hydratase
EP12_RS02870	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP12_RS02880	COG0006	proline dipeptidase activity
EP12_RS02890	COG0142	geranyltranstransferase activity
EP12_RS02940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EP12_RS02945	COG4942	peptidase
EP12_RS02945	COG1388	LysM domain
EP12_RS02950	COG1238	metal cluster binding
EP12_RS02960	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EP12_RS02965	COG0585	pseudouridine synthase activity
EP12_RS02980	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EP12_RS02990	COG0840	transmembrane signaling receptor activity
EP12_RS03000	COG1538	Outer membrane efflux protein
EP12_RS03045	COG0494	nUDIX hydrolase
EP12_RS03055	COG0730	response to heat
EP12_RS03060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EP12_RS03080	COG0784	Response regulator, receiver
EP12_RS03080	COG2205	protein histidine kinase activity
EP12_RS03100	COG0564	pseudouridine synthase activity
EP12_RS03120	COG1648	precorrin-2 dehydrogenase activity
EP12_RS03120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EP12_RS03145	COG1538	Outer membrane efflux protein
EP12_RS03150	COG0494	nUDIX hydrolase
EP12_RS03155	COG3151	Protein conserved in bacteria
EP12_RS03165	COG3150	esterase
EP12_RS03180	COG4251	negative regulation of phosphorylation
EP12_RS03185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP12_RS03205	COG1509	lysine 2,3-aminomutase activity
EP12_RS03210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EP12_RS03215	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EP12_RS03230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EP12_RS03245	COG0271	Belongs to the BolA IbaG family
EP12_RS03255	COG3707	response regulator
EP12_RS03265	COG0659	secondary active sulfate transmembrane transporter activity
EP12_RS03270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP12_RS03275	COG2146	nitrite reductase [NAD(P)H] activity
EP12_RS03280	COG0243	molybdopterin cofactor binding
EP12_RS03285	COG1648	precorrin-2 dehydrogenase activity
EP12_RS03285	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EP12_RS03290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EP12_RS03300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EP12_RS03300	COG1116	anion transmembrane transporter activity
EP12_RS03305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP12_RS03310	COG1116	anion transmembrane transporter activity
EP12_RS03320	COG0746	molybdenum cofactor guanylyltransferase activity
EP12_RS03330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EP12_RS03335	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EP12_RS03340	COG0348	domain, Protein
EP12_RS03360	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_RS03370	COG4948	Mandelate Racemase Muconate Lactonizing
EP12_RS03390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP12_RS03430	COG0358	DNA primase activity
EP12_RS03450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EP12_RS03470	COG0537	adenosine 5'-monophosphoramidase activity
EP12_RS03485	COG3135	benzoate transporter
EP12_RS03490	COG1396	sequence-specific DNA binding
EP12_RS03495	COG2974	May be involved in recombination
EP12_RS03500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP12_RS03500	COG4191	Histidine kinase
EP12_RS03505	COG0745	RESPONSE REGULATOR receiver
EP12_RS03510	COG5002	protein histidine kinase activity
EP12_RS03540	COG0811	peptide transport
EP12_RS03545	COG0811	peptide transport
EP12_RS03550	COG0848	biopolymer transport protein
EP12_RS03565	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EP12_RS03570	COG3437	response regulator, receiver
EP12_RS03575	COG5002	protein histidine kinase activity
EP12_RS03575	COG0784	Response regulator, receiver
EP12_RS03575	COG2205	protein histidine kinase activity
EP12_RS03590	COG2133	pyrroloquinoline quinone binding
EP12_RS03595	COG1049	propionate catabolic process, 2-methylcitrate cycle
EP12_RS03605	COG1793	dna ligase
EP12_RS03620	COG0527	aspartate kinase activity
EP12_RS03625	COG0840	transmembrane signaling receptor activity
EP12_RS03635	COG2967	ApaG domain
EP12_RS03640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EP12_RS03645	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EP12_RS03650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP12_RS03655	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EP12_RS03660	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EP12_RS03670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EP12_RS03675	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EP12_RS03690	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EP12_RS03700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EP12_RS03705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP12_RS03710	COG3956	TIGRFAM MazG family protein
EP12_RS03725	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EP12_RS03730	COG1595	DNA-templated transcription, initiation
EP12_RS03740	COG4206	TonB-dependent receptor
EP12_RS03750	COG0723	plastoquinol--plastocyanin reductase activity
EP12_RS03755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EP12_RS03760	COG2857	Cytochrome c1
EP12_RS03765	COG0625	glutathione transferase activity
EP12_RS03770	COG2969	positive regulation of protein catabolic process
EP12_RS03785	COG0745	RESPONSE REGULATOR receiver
EP12_RS03790	COG2239	Acts as a magnesium transporter
EP12_RS03795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EP12_RS03815	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EP12_RS03820	COG1137	ATPase activity
EP12_RS03835	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EP12_RS03850	COG1127	ABC transporter
EP12_RS03855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EP12_RS03860	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EP12_RS03865	COG2854	intermembrane phospholipid transfer
EP12_RS03875	COG5007	Belongs to the BolA IbaG family
EP12_RS03885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP12_RS03890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP12_RS03900	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EP12_RS03955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP12_RS03965	COG2205	protein histidine kinase activity
EP12_RS03965	COG0784	Response regulator, receiver
EP12_RS03980	COG1979	alcohol dehydrogenase
EP12_RS04005	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EP12_RS04015	COG0126	phosphoglycerate kinase activity
EP12_RS04020	COG3588	fructose-bisphosphate aldolase
EP12_RS04025	COG0248	Ppx GppA phosphatase
EP12_RS04030	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EP12_RS04040	COG0573	inorganic phosphate transmembrane transporter activity
EP12_RS04050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EP12_RS04060	COG0306	phosphate transporter
EP12_RS04065	COG0589	response to stress
EP12_RS04070	COG0583	DNA-binding transcription factor activity
EP12_RS04080	COG1272	protein, Hemolysin III
EP12_RS04085	COG1846	Transcriptional regulator
EP12_RS04090	COG1764	response to oxidative stress
EP12_RS04100	COG1739	Uncharacterized protein family UPF0029
EP12_RS04110	COG0420	3'-5' exonuclease activity
EP12_RS04115	COG0419	ATPase involved in DNA repair
EP12_RS04120	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EP12_RS04130	COG1073	alpha beta
EP12_RS04135	COG2207	Transcriptional regulator
EP12_RS04140	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
EP12_RS04155	COG0625	glutathione transferase activity
EP12_RS04175	COG2971	BadF BadG BcrA BcrD
EP12_RS04200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EP12_RS04205	COG0668	transmembrane transport
EP12_RS04240	COG2897	thiosulfate sulfurtransferase activity
EP12_RS04245	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EP12_RS04250	COG3148	PFAM DTW domain containing protein
EP12_RS04295	COG1380	Effector of murein hydrolase LrgA
EP12_RS04300	COG1346	cytolysis
EP12_RS04330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EP12_RS04335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EP12_RS04340	COG0513	Belongs to the DEAD box helicase family
EP12_RS04350	COG3409	Peptidoglycan-binding domain 1 protein
EP12_RS04350	COG3267	Type II secretory pathway component ExeA
EP12_RS04365	COG0066	3-isopropylmalate dehydratase activity
EP12_RS04375	COG0473	3-isopropylmalate dehydrogenase activity
EP12_RS04380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EP12_RS04425	COG4555	ABC transporter
EP12_RS04430	COG1668	transmembrane transport
EP12_RS04445	COG4133	protoheme IX ABC transporter activity
EP12_RS04450	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP12_RS04455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP12_RS04460	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP12_RS04470	COG1138	Cytochrome C-type biogenesis protein
EP12_RS04475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EP12_RS04495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EP12_RS04535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EP12_RS04540	COG1216	Glycosyl transferase, family 2
EP12_RS04540	COG0463	Glycosyl transferase, family 2
EP12_RS04550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EP12_RS04555	COG1596	polysaccharide export
EP12_RS04555	COG1555	photosystem II stabilization
EP12_RS04560	COG0473	3-isopropylmalate dehydrogenase activity
EP12_RS04575	COG1611	Belongs to the LOG family
EP12_RS04585	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EP12_RS04585	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EP12_RS04675	COG0564	pseudouridine synthase activity
EP12_RS04690	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EP12_RS04695	COG0024	Methionine aminopeptidase
EP12_RS04700	COG0052	Belongs to the universal ribosomal protein uS2 family
EP12_RS04710	COG0528	UMP kinase activity
EP12_RS04720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EP12_RS04725	COG0575	Belongs to the CDS family
EP12_RS04750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EP12_RS04755	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP12_RS04775	COG0825	malonyl-CoA metabolic process
EP12_RS04810	COG0047	phosphoribosylformylglycinamidine synthase activity
EP12_RS04810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EP12_RS04815	COG2840	Smr protein MutS2
EP12_RS04850	COG0835	chemotaxis
EP12_RS04850	COG0784	Response regulator, receiver
EP12_RS04855	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EP12_RS04860	COG1815	bacterial-type flagellum-dependent cell motility
EP12_RS04880	COG4787	bacterial-type flagellum-dependent cell motility
EP12_RS04900	COG3951	Flagellar rod assembly protein muramidase FlgJ
EP12_RS04900	COG1705	Flagellar rod assembly protein muramidase FlgJ
EP12_RS04905	COG1256	bacterial-type flagellum assembly
EP12_RS04925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP12_RS04945	COG1516	flagellar protein fliS
EP12_RS04955	COG1086	Polysaccharide biosynthesis protein
EP12_RS04960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EP12_RS04965	COG1083	cytidylyl-transferase
EP12_RS04970	COG2089	acid synthase
EP12_RS04990	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_RS05045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EP12_RS05050	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EP12_RS05060	COG3475	LICD family
EP12_RS05065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EP12_RS05105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EP12_RS05135	COG1677	Flagellar hook-basal body complex protein FliE
EP12_RS05140	COG1766	The M ring may be actively involved in energy transduction
EP12_RS05145	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EP12_RS05195	COG1987	bacterial-type flagellum assembly
EP12_RS05210	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EP12_RS05235	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EP12_RS05240	COG2198	Histidine kinase
EP12_RS05240	COG0784	Response regulator, receiver
EP12_RS05240	COG0643	Histidine kinase
EP12_RS05245	COG2201	protein-glutamate methylesterase activity
EP12_RS05250	COG1192	Involved in chromosome partitioning
EP12_RS05260	COG0835	chemotaxis
EP12_RS05290	COG3123	guanosine phosphorylase activity
EP12_RS05295	COG0583	DNA-binding transcription factor activity
EP12_RS05300	COG0583	DNA-binding transcription factor activity
EP12_RS05305	COG0288	reversible hydration of carbon dioxide
EP12_RS05325	COG2137	regulation of response to DNA damage stimulus
EP12_RS05330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EP12_RS05365	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EP12_RS05375	COG4172	Belongs to the ABC transporter superfamily
EP12_RS05380	COG4171	peptide transport system, permease
EP12_RS05385	COG0601	transmembrane transport
EP12_RS05390	COG0747	negative chemotaxis
EP12_RS05395	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EP12_RS05400	COG1842	Phage shock protein A
EP12_RS05430	COG0625	glutathione transferase activity
EP12_RS05435	COG1522	sequence-specific DNA binding
EP12_RS05470	COG0811	peptide transport
EP12_RS05475	COG0811	peptide transport
EP12_RS05495	COG3385	transposase activity
EP12_RS05500	COG1444	tRNA N-acetyltransferase activity
EP12_RS05540	COG0456	acetyltransferase
EP12_RS05565	COG0656	L-ascorbic acid biosynthetic process
EP12_RS05615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EP12_RS05635	COG0633	Ferredoxin
EP12_RS05635	COG0543	2 iron, 2 sulfur cluster binding
EP12_RS05645	COG3547	Transposase (IS116 IS110 IS902 family)
EP12_RS05715	COG0564	pseudouridine synthase activity
EP12_RS05730	COG2918	glutathione biosynthetic process
EP12_RS05745	COG1136	(ABC) transporter
EP12_RS05775	COG2840	Smr protein MutS2
EP12_RS05780	COG2890	protein-(glutamine-N5) methyltransferase activity
EP12_RS05800	COG2719	SpoVR family
EP12_RS05815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EP12_RS05820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EP12_RS05860	COG0584	glycerophosphoryl diester phosphodiesterase
EP12_RS05865	COG0346	lactoylglutathione lyase activity
EP12_RS05870	COG1278	Cold shock
EP12_RS05880	COG3706	GGDEF domain
EP12_RS05885	COG3710	Transcriptional regulator
EP12_RS05970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EP12_RS05975	COG4660	Part of a membrane complex involved in electron transport
EP12_RS05980	COG4659	FMN binding
EP12_RS05985	COG4658	electron transport chain
EP12_RS05995	COG2878	Part of a membrane complex involved in electron transport
EP12_RS06000	COG4657	Part of a membrane complex involved in electron transport
EP12_RS06015	COG0534	Mate efflux family protein
EP12_RS06020	COG0556	nucleotide-excision repair
EP12_RS06045	COG0602	queuosine metabolic process
EP12_RS06055	COG0367	asparagine synthase
EP12_RS06080	COG3273	potassium ion transport
EP12_RS06080	COG0471	metal ion transport
EP12_RS06095	COG0529	Catalyzes the synthesis of activated sulfate
EP12_RS06100	COG0175	sulfate reduction
EP12_RS06105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP12_RS06120	COG1595	DNA-templated transcription, initiation
EP12_RS06135	COG2304	oxidoreductase activity
EP12_RS06155	COG0714	Associated with various cellular activities
EP12_RS06165	COG1024	Enoyl-CoA hydratase
EP12_RS06165	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP12_RS06180	COG1025	Belongs to the peptidase M16 family
EP12_RS06185	COG2062	phosphohistidine phosphatase, SixA
EP12_RS06195	COG4536	flavin adenine dinucleotide binding
EP12_RS06200	COG4137	Cytochrome C assembly protein
EP12_RS06210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EP12_RS06250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP12_RS06255	COG1132	(ABC) transporter
EP12_RS06260	COG2873	o-acetylhomoserine
EP12_RS06275	COG0228	four-way junction DNA binding
EP12_RS06280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EP12_RS06285	COG0336	Belongs to the RNA methyltransferase TrmD family
EP12_RS06290	COG0335	large ribosomal subunit rRNA binding
EP12_RS06295	COG2860	membrane
EP12_RS06305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EP12_RS06310	COG0287	Prephenate dehydrogenase
EP12_RS06310	COG1605	Chorismate mutase
EP12_RS06315	COG1605	Chorismate mutase
EP12_RS06315	COG0077	Prephenate dehydratase
EP12_RS06325	COG0745	RESPONSE REGULATOR receiver
EP12_RS06330	COG0023	Translation Initiation Factor
EP12_RS06360	COG2205	protein histidine kinase activity
EP12_RS06370	COG2204	response regulator
EP12_RS06375	COG1801	Protein of unknown function DUF72
EP12_RS06380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EP12_RS06385	COG0494	nUDIX hydrolase
EP12_RS06390	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EP12_RS06395	COG0632	four-way junction helicase activity
EP12_RS06400	COG2255	four-way junction helicase activity
EP12_RS06405	COG0824	Thioesterase
EP12_RS06410	COG0811	peptide transport
EP12_RS06430	COG2885	chlorophyll binding
EP12_RS06435	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EP12_RS06455	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EP12_RS06555	COG4387	Mu-like prophage protein GP36
EP12_RS06565	COG4397	Mu-like prophage major head subunit gpT
EP12_RS06570	COG4388	Caudovirus prohead serine protease
EP12_RS06600	COG4383	Mu-like prophage protein gp29
EP12_RS06605	COG4373	Mu-like prophage FluMu protein gp28
EP12_RS06725	COG3423	Transcriptional regulator
EP12_RS06735	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_RS06770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP12_RS06780	COG0612	Peptidase, M16
EP12_RS06800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP12_RS06805	COG4221	oxidoreductase activity
EP12_RS06810	COG0753	catalase activity
EP12_RS06815	COG3038	cytochrome b561
EP12_RS06820	COG0583	DNA-binding transcription factor activity
EP12_RS06825	COG0604	alcohol dehydrogenase
EP12_RS06825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EP12_RS06825	COG3321	synthase
EP12_RS06825	COG4221	oxidoreductase activity
EP12_RS06870	COG3008	intermembrane lipid transfer
EP12_RS06870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EP12_RS06875	COG2995	paraquat-inducible protein a
EP12_RS06900	COG3093	addiction module antidote protein HigA
EP12_RS06920	COG0017	Asparaginyl-tRNA synthetase
EP12_RS06935	COG0189	ligase activity
EP12_RS06980	COG3340	Belongs to the peptidase S51 family
EP12_RS06985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EP12_RS06990	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EP12_RS07000	COG1131	(ABC) transporter
EP12_RS07005	COG2972	Histidine kinase
EP12_RS07010	COG3279	Response regulator of the LytR AlgR family
EP12_RS07020	COG5265	(ABC) transporter
EP12_RS07025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EP12_RS07085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP12_RS07090	COG0402	S-adenosylhomocysteine deaminase activity
EP12_RS07110	COG2755	lipolytic protein G-D-S-L family
EP12_RS07115	COG4181	ATPase activity
EP12_RS07125	COG1090	epimerase
EP12_RS07130	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EP12_RS07135	COG0628	permease
EP12_RS07160	COG2350	Protein conserved in bacteria
EP12_RS07165	COG0159	tryptophan synthase activity
EP12_RS07175	COG0135	phosphoribosylanthranilate isomerase activity
EP12_RS07175	COG0134	indole-3-glycerol-phosphate synthase activity
EP12_RS07190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EP12_RS07195	COG0613	PHP domain protein
EP12_RS07200	COG0009	L-threonylcarbamoyladenylate synthase
EP12_RS07205	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EP12_RS07210	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EP12_RS07220	COG0656	L-ascorbic acid biosynthetic process
EP12_RS07225	COG0110	maltose O-acetyltransferase activity
EP12_RS07240	COG2733	membrane
EP12_RS07245	COG0500	methyltransferase
EP12_RS07250	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP12_RS07265	COG0783	Belongs to the Dps family
EP12_RS07270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EP12_RS07275	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_RS07285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EP12_RS07295	COG4771	TonB-dependent receptor
EP12_RS07315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EP12_RS07325	COG0484	heat shock protein binding
EP12_RS07330	COG3909	cytochrome
EP12_RS07335	COG5001	Diguanylate cyclase
EP12_RS07335	COG3300	MHYT domain
EP12_RS07345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EP12_RS07355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EP12_RS07360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EP12_RS07375	COG0071	Belongs to the small heat shock protein (HSP20) family
EP12_RS07390	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EP12_RS07395	COG4535	Mg2 and Co2 transporter CorC
EP12_RS07400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EP12_RS07420	COG1702	phosphate starvation-inducible protein PhoH
EP12_RS07430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP12_RS07450	COG1607	acyl-coa hydrolase
EP12_RS07455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EP12_RS07460	COG1115	amino acid carrier protein
EP12_RS07550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EP12_RS07555	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EP12_RS07570	COG2890	protein-(glutamine-N5) methyltransferase activity
EP12_RS07575	COG0784	Response regulator, receiver
EP12_RS07575	COG3437	response regulator, receiver
EP12_RS07585	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EP12_RS07595	COG0583	DNA-binding transcription factor activity
EP12_RS07605	COG2363	Small membrane protein
EP12_RS07615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EP12_RS07625	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EP12_RS07630	COG2815	serine threonine protein kinase
EP12_RS07630	COG0515	serine threonine protein kinase
EP12_RS07640	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EP12_RS07645	COG0033	Phosphoglucomutase
EP12_RS07650	COG0058	SHG alpha-glucan phosphorylase activity
EP12_RS07660	COG2988	succinylglutamate desuccinylase activity
EP12_RS07690	COG1393	Belongs to the ArsC family
EP12_RS07715	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EP12_RS07750	COG0740	serine-type endopeptidase activity
EP12_RS07805	COG5001	Diguanylate cyclase
EP12_RS07805	COG5002	protein histidine kinase activity
EP12_RS07805	COG3447	MASE1 domain protein
EP12_RS07820	COG2351	hydroxyisourate hydrolase activity
EP12_RS07835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EP12_RS07845	COG1309	transcriptional regulator
EP12_RS07860	COG2252	PERMEase
EP12_RS07865	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EP12_RS07875	COG3300	MHYT domain
EP12_RS07875	COG5001	Diguanylate cyclase
EP12_RS07885	COG0784	Response regulator, receiver
EP12_RS07885	COG2205	protein histidine kinase activity
EP12_RS07915	COG2233	PERMEase
EP12_RS07935	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EP12_RS07940	COG0730	response to heat
EP12_RS07980	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_RS07985	COG3001	Fructosamine kinase
EP12_RS07995	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EP12_RS08015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EP12_RS08025	COG1596	polysaccharide export
EP12_RS08035	COG4464	protein tyrosine phosphatase activity
EP12_RS08090	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EP12_RS08090	COG2755	lipolytic protein G-D-S-L family
EP12_RS08140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP12_RS08140	COG0072	phenylalanine-tRNA ligase activity
EP12_RS08165	COG1472	Belongs to the glycosyl hydrolase 3 family
EP12_RS08170	COG2096	Adenosyltransferase
EP12_RS08180	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EP12_RS08190	COG4591	ABC-type transport system involved in lipoprotein release permease component
EP12_RS08195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EP12_RS08205	COG0708	Exodeoxyribonuclease III
EP12_RS08240	COG2814	Major facilitator Superfamily
EP12_RS08270	COG4770	biotin carboxylase activity
EP12_RS08280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EP12_RS08290	COG0789	Transcriptional regulator
EP12_RS08295	COG0183	Belongs to the thiolase family
EP12_RS08310	COG2925	Exonuclease
EP12_RS08370	COG3321	synthase
EP12_RS08370	COG0604	alcohol dehydrogenase
EP12_RS08375	COG0328	RNA-DNA hybrid ribonuclease activity
EP12_RS08415	COG1136	(ABC) transporter
EP12_RS08420	COG4591	ABC-type transport system involved in lipoprotein release permease component
EP12_RS08435	COG3724	N-succinylarginine dihydrolase activity
EP12_RS08440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EP12_RS08445	COG3122	Protein conserved in bacteria
EP12_RS08450	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EP12_RS08455	COG2153	protein acetylation
EP12_RS08475	COG0564	pseudouridine synthase activity
EP12_RS08480	COG0546	phosphoglycolate phosphatase activity
EP12_RS08490	COG1399	metal-binding, possibly nucleic acid-binding protein
EP12_RS08520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EP12_RS08525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EP12_RS08535	COG0596	Alpha beta hydrolase
EP12_RS08550	COG1960	acyl-CoA dehydrogenase activity
EP12_RS08560	COG2390	Transcriptional regulator
EP12_RS08565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP12_RS08595	COG0668	transmembrane transport
EP12_RS08600	COG4771	TonB-dependent receptor
EP12_RS08625	COG3437	response regulator, receiver
EP12_RS08635	COG0195	Participates in both transcription termination and antitermination
EP12_RS08650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EP12_RS08660	COG3706	GGDEF domain
EP12_RS08665	COG0596	Alpha beta hydrolase
EP12_RS08675	COG3153	acetyltransferase
EP12_RS08675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP12_RS08745	COG1032	radical SAM domain protein
EP12_RS08760	COG4771	TonB-dependent receptor
EP12_RS08765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP12_RS08775	COG4134	Bacterial extracellular solute-binding protein
EP12_RS08780	COG4135	transport system, permease component
EP12_RS08785	COG4136	ATPase activity
EP12_RS08790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EP12_RS08800	COG3932	Exopolysaccharide synthesis, ExoD
EP12_RS08805	COG0604	alcohol dehydrogenase
EP12_RS08840	COG0840	transmembrane signaling receptor activity
EP12_RS08860	COG1131	(ABC) transporter
EP12_RS08875	COG1902	pentaerythritol trinitrate reductase activity
EP12_RS08885	COG2867	negative regulation of translational initiation
EP12_RS08890	COG2914	Belongs to the UPF0125 (RnfH) family
EP12_RS08900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EP12_RS08905	COG4771	TonB-dependent receptor
EP12_RS08910	COG0457	Tetratricopeptide repeat
EP12_RS08940	COG0247	lactate metabolic process
EP12_RS08940	COG0277	FAD linked oxidase domain protein
EP12_RS08950	COG2850	peptidyl-arginine hydroxylation
EP12_RS08960	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EP12_RS08965	COG2915	High frequency lysogenization protein hflD homolog
EP12_RS08970	COG0482	sulfurtransferase activity
EP12_RS08975	COG1187	pseudouridine synthase activity
EP12_RS08985	COG1278	Cold shock
EP12_RS08990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EP12_RS08995	COG0542	response to heat
EP12_RS09000	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EP12_RS09005	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EP12_RS09010	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EP12_RS09015	COG0492	ferredoxin-NADP+ reductase activity
EP12_RS09020	COG3092	negative regulation of chromosome organization
EP12_RS09025	COG3091	SprT-like family
EP12_RS09030	COG0616	signal peptide processing
EP12_RS09040	COG0778	Nitroreductase
EP12_RS09050	COG0252	asparaginase activity
EP12_RS09055	COG3706	GGDEF domain
EP12_RS09060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EP12_RS09065	COG0321	lipoyl(octanoyl) transferase activity
EP12_RS09070	COG2921	Belongs to the UPF0250 family
EP12_RS09075	COG1686	Belongs to the peptidase S11 family
EP12_RS09080	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EP12_RS09085	COG0772	Belongs to the SEDS family
EP12_RS09090	COG0768	penicillin binding
EP12_RS09095	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EP12_RS09100	COG0799	negative regulation of ribosome biogenesis
EP12_RS09105	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EP12_RS09110	COG1466	dna polymerase III delta subunit
EP12_RS09115	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EP12_RS09120	COG0495	leucyl-tRNA aminoacylation
EP12_RS09125	COG1067	ATP-dependent peptidase activity
EP12_RS09135	COG1534	Rna-binding protein
EP12_RS09140	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EP12_RS09145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP12_RS09150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EP12_RS09155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EP12_RS09160	COG0149	triose-phosphate isomerase activity
EP12_RS09165	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EP12_RS09190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EP12_RS09205	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_RS09220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP12_RS09225	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EP12_RS09230	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EP12_RS09245	COG1185	polyribonucleotide nucleotidyltransferase activity
EP12_RS09265	COG0295	cytidine deaminase activity
EP12_RS09280	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EP12_RS09285	COG1196	nuclear chromosome segregation
EP12_RS09295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EP12_RS09305	COG2333	competence protein COMEC
EP12_RS09305	COG0658	competence protein
EP12_RS09310	COG1132	(ABC) transporter
EP12_RS09315	COG1663	tetraacyldisaccharide 4'-kinase activity
EP12_RS09395	COG2808	Putative FMN-binding domain
EP12_RS09435	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EP12_RS09465	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EP12_RS09470	COG1053	succinate dehydrogenase
EP12_RS09475	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EP12_RS09480	COG0567	Dehydrogenase, E1 component
EP12_RS09485	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP12_RS09540	COG0366	Alpha amylase catalytic
EP12_RS09565	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_RS09570	COG2267	carboxylic ester hydrolase activity
EP12_RS09580	COG0616	signal peptide processing
EP12_RS09595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EP12_RS09600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EP12_RS09605	COG0386	Belongs to the glutathione peroxidase family
EP12_RS09610	COG2084	Dehydrogenase
EP12_RS09625	COG1960	acyl-CoA dehydrogenase activity
EP12_RS09630	COG1024	Enoyl-CoA hydratase
EP12_RS09640	COG2226	methyltransferase
EP12_RS09645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EP12_RS09650	COG3083	sulfuric ester hydrolase activity
EP12_RS09655	COG3082	Protein of unknown function (DUF1414)
EP12_RS09660	COG3081	Nucleoid-associated protein
EP12_RS09690	COG3275	phosphorelay sensor kinase activity
EP12_RS09695	COG3279	Response regulator of the LytR AlgR family
EP12_RS09700	COG0205	6-phosphofructokinase activity
EP12_RS09730	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EP12_RS09755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP12_RS09780	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EP12_RS09815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP12_RS09815	COG2205	protein histidine kinase activity
EP12_RS09845	COG0513	Belongs to the DEAD box helicase family
EP12_RS09855	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EP12_RS09890	COG1760	l-serine dehydratase
EP12_RS09915	COG2199	diguanylate cyclase activity
EP12_RS09930	COG1404	Belongs to the peptidase S8 family
EP12_RS09940	COG0022	dehydrogenase e1 component
EP12_RS09950	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EP12_RS09955	COG0515	serine threonine protein kinase
EP12_RS09960	COG1946	Acyl-CoA thioesterase
EP12_RS09970	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EP12_RS09980	COG1956	GAF domain-containing protein
EP12_RS09995	COG0793	Belongs to the peptidase S41A family
EP12_RS10000	COG0733	neurotransmitter:sodium symporter activity
EP12_RS10055	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP12_RS10100	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_RS10145	COG0309	Hydrogenase expression formation protein (HypE)
EP12_RS10150	COG0789	Transcriptional regulator
EP12_RS10155	COG2217	Heavy metal translocating P-type atpase
EP12_RS10195	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EP12_RS10210	COG3667	copper resistance
EP12_RS10215	COG2132	Multicopper oxidase
EP12_RS10245	COG0789	Transcriptional regulator
EP12_RS10295	COG4772	TonB-dependent receptor
EP12_RS10350	COG2801	Transposase and inactivated derivatives
EP12_RS10400	COG5002	protein histidine kinase activity
EP12_RS10405	COG0745	RESPONSE REGULATOR receiver
EP12_RS10435	COG0167	dihydroorotate dehydrogenase activity
EP12_RS10450	COG0488	(ABC) transporter
EP12_RS10460	COG3130	regulation of translation
EP12_RS10465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EP12_RS10475	COG0415	Belongs to the DNA photolyase family
EP12_RS10480	COG0415	Belongs to the DNA photolyase family
EP12_RS10485	COG0415	Belongs to the DNA photolyase family
EP12_RS10490	COG3046	protein related to deoxyribodipyrimidine photolyase
EP12_RS10510	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EP12_RS10515	COG0589	response to stress
EP12_RS10540	COG2193	ferroxidase activity
EP12_RS10550	COG3278	Belongs to the heme-copper respiratory oxidase family
EP12_RS10565	COG2010	Cytochrome c
EP12_RS10590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP12_RS10595	COG0589	response to stress
EP12_RS10600	COG0037	tRNA processing
EP12_RS10605	COG1752	Esterase of the alpha-beta hydrolase superfamily
EP12_RS10625	COG1280	lysine exporter protein (LysE YggA)
EP12_RS10635	COG2897	thiosulfate sulfurtransferase activity
EP12_RS10640	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EP12_RS10645	COG3148	PFAM DTW domain containing protein
EP12_RS10700	COG0582	viral genome integration into host DNA
EP12_RS10725	COG0322	excinuclease ABC activity
EP12_RS10730	COG2197	response regulator
EP12_RS10735	COG1741	Belongs to the pirin family
EP12_RS10740	COG0436	Aminotransferase
EP12_RS10745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EP12_RS10755	COG3384	dioxygenase
EP12_RS10760	COG2259	Doxx family
EP12_RS10765	COG0583	DNA-binding transcription factor activity
EP12_RS10780	COG0670	Belongs to the BI1 family
EP12_RS10785	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EP12_RS10800	COG2920	part of a sulfur-relay system
EP12_RS10805	COG0561	phosphatase activity
EP12_RS10835	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EP12_RS10840	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EP12_RS10845	COG1674	ftsk spoiiie
EP12_RS10845	COG0531	amino acid
EP12_RS10855	COG0686	Belongs to the AlaDH PNT family
EP12_RS10860	COG0284	orotidine-5'-phosphate decarboxylase activity
EP12_RS10865	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EP12_RS10880	COG0776	regulation of translation
EP12_RS10885	COG0539	negative regulation of cytoplasmic translation
EP12_RS10890	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EP12_RS10895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EP12_RS10900	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EP12_RS10920	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EP12_RS10925	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EP12_RS10930	COG0633	Ferredoxin
EP12_RS10970	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EP12_RS10975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EP12_RS10985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EP12_RS10995	COG4783	chaperone-mediated protein folding
EP12_RS11000	COG4232	protein-disulfide reductase activity
EP12_RS11040	COG0789	Transcriptional regulator
EP12_RS11070	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EP12_RS11120	COG3769	mannosylglycerate metabolic process
EP12_RS11125	COG1215	transferase activity, transferring glycosyl groups
EP12_RS11140	COG0303	'Molybdopterin
EP12_RS11145	COG0534	Mate efflux family protein
EP12_RS11165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EP12_RS11180	COG2801	Transposase and inactivated derivatives
EP12_RS11185	COG2963	transposase activity
EP12_RS11195	COG0405	Gamma-glutamyltransferase
EP12_RS11200	COG1024	Enoyl-CoA hydratase
EP12_RS11240	COG1448	Aminotransferase
EP12_RS11250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EP12_RS11260	COG1671	Belongs to the UPF0178 family
EP12_RS11265	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_RS11270	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_RS11275	COG1960	acyl-CoA dehydrogenase activity
EP12_RS11280	COG4977	sequence-specific DNA binding
EP12_RS11330	COG0596	Alpha beta hydrolase
EP12_RS11340	COG0716	FMN binding
EP12_RS11350	COG0735	belongs to the Fur family
EP12_RS11360	COG1984	allophanate hydrolase subunit 2
EP12_RS11370	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EP12_RS11375	COG2996	Protein conserved in bacteria
EP12_RS11380	COG1765	OsmC-like protein
EP12_RS11400	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EP12_RS11405	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EP12_RS11420	COG4771	TonB-dependent receptor
EP12_RS11425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EP12_RS11435	COG1238	metal cluster binding
EP12_RS11445	COG3012	SEC-C Motif Domain Protein
EP12_RS11460	COG0456	acetyltransferase
EP12_RS11465	COG3706	GGDEF domain
EP12_RS11470	COG0702	epimerase
EP12_RS11480	COG0084	hydrolase, TatD family'
EP12_RS11495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EP12_RS11500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EP12_RS11550	COG1618	nucleotide phosphatase activity, acting on free nucleotides
EP12_RS11550	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EP12_RS11570	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EP12_RS11575	COG0315	cyclic pyranopterin monophosphate synthase activity
EP12_RS11580	COG0521	Mo-molybdopterin cofactor biosynthetic process
EP12_RS11585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EP12_RS11605	COG0436	Aminotransferase
EP12_RS11610	COG3268	Saccharopine dehydrogenase
EP12_RS11615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP12_RS11640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EP12_RS11645	COG1074	ATP-dependent DNA helicase activity
EP12_RS11650	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EP12_RS11660	COG1022	Amp-dependent synthetase and ligase
EP12_RS11675	COG3132	Protein of unknown function, DUF480
EP12_RS11690	COG0583	DNA-binding transcription factor activity
EP12_RS11695	COG3085	chromosome segregation
EP12_RS11705	COG0640	Transcriptional regulator
EP12_RS11725	COG2204	response regulator
EP12_RS11735	COG4251	negative regulation of phosphorylation
EP12_RS11740	COG0784	Response regulator, receiver
EP12_RS11745	COG2205	protein histidine kinase activity
EP12_RS11745	COG0784	Response regulator, receiver
EP12_RS11790	COG3139	Protein of unknown function (DUF1315)
EP12_RS11800	COG1115	amino acid carrier protein
EP12_RS11825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EP12_RS11840	COG1640	4-alpha-glucanotransferase
EP12_RS11850	COG0676	glucose-6-phosphate 1-epimerase activity
EP12_RS11855	COG0800	Aldolase
EP12_RS11860	COG0837	glucose binding
EP12_RS11865	COG0129	dihydroxy-acid dehydratase activity
EP12_RS11875	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EP12_RS11880	COG1737	Transcriptional regulator
EP12_RS11885	COG0469	pyruvate kinase activity
EP12_RS11890	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EP12_RS11930	COG2205	protein histidine kinase activity
EP12_RS11935	COG0745	RESPONSE REGULATOR receiver
EP12_RS11960	COG3665	Urea carboxylase-associated protein
EP12_RS11975	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EP12_RS12000	COG2721	sulfolactate sulfo-lyase activity
EP12_RS12005	COG1904	glucuronate isomerase
EP12_RS12010	COG0246	Mannitol dehydrogenase
EP12_RS12015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP12_RS12020	COG2755	lipolytic protein G-D-S-L family
EP12_RS12030	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EP12_RS12040	COG4677	pectinesterase activity
EP12_RS12060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP12_RS12070	COG1119	ATPase activity
EP12_RS12085	COG1609	Transcriptional regulator
EP12_RS12090	COG4948	Mandelate Racemase Muconate Lactonizing
EP12_RS12110	COG3300	MHYT domain
EP12_RS12110	COG5001	Diguanylate cyclase
EP12_RS12130	COG0745	RESPONSE REGULATOR receiver
EP12_RS12135	COG2205	protein histidine kinase activity
EP12_RS12145	COG0784	Response regulator, receiver
EP12_RS12145	COG3437	response regulator, receiver
EP12_RS12155	COG0471	metal ion transport
EP12_RS12165	COG0489	protein tyrosine kinase activity
EP12_RS12170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP12_RS12170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP12_RS12175	COG2226	methyltransferase
EP12_RS12180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP12_RS12200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EP12_RS12210	COG1785	Belongs to the alkaline phosphatase family
EP12_RS12215	COG1785	Belongs to the alkaline phosphatase family
EP12_RS12240	COG0583	DNA-binding transcription factor activity
EP12_RS12245	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EP12_RS12260	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EP12_RS12265	COG1286	toxin biosynthetic process
EP12_RS12270	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EP12_RS12275	COG0285	dihydrofolate synthase activity
EP12_RS12310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EP12_RS12405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EP12_RS12415	COG4399	Belongs to the UPF0754 family
EP12_RS12445	COG2186	Transcriptional regulator
EP12_RS12455	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EP12_RS12460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EP12_RS12465	COG2983	Belongs to the UPF0260 family
EP12_RS12470	COG0179	Fumarylacetoacetate (FAA) hydrolase
EP12_RS12485	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EP12_RS12490	COG0318	PFAM AMP-dependent synthetase and ligase
EP12_RS12495	COG2267	carboxylic ester hydrolase activity
EP12_RS12510	COG1214	PFAM Peptidase M22, glycoprotease
EP12_RS12515	COG1199	ATP-dependent helicase activity
EP12_RS12560	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EP12_RS12570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP12_RS12575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EP12_RS12575	COG0131	Imidazoleglycerol-phosphate dehydratase
EP12_RS12595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EP12_RS12595	COG0140	phosphoribosyl-ATP diphosphatase activity
EP12_RS12605	COG0583	DNA-binding transcription factor activity
EP12_RS12635	COG0326	Molecular chaperone. Has ATPase activity
EP12_RS12640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EP12_RS12660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EP12_RS12665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EP12_RS12675	COG3220	belongs to the UPF0276 family
EP12_RS12685	COG2319	Wd-40 repeat
EP12_RS12685	COG4249	Peptidase C14 caspase catalytic subunit p20
EP12_RS12695	COG3706	GGDEF domain
EP12_RS12695	COG4251	negative regulation of phosphorylation
EP12_RS12695	COG5001	Diguanylate cyclase
EP12_RS12695	COG2203	Gaf domain
EP12_RS12740	COG0542	response to heat
EP12_RS12750	COG0564	pseudouridine synthase activity
EP12_RS12765	COG1595	DNA-templated transcription, initiation
EP12_RS12780	COG4221	oxidoreductase activity
EP12_RS12805	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EP12_RS12815	COG0142	geranyltranstransferase activity
EP12_RS12825	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EP12_RS12840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EP12_RS12855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EP12_RS12855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EP12_RS12870	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP12_RS12885	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EP12_RS12895	COG0560	Phosphoserine phosphatase
EP12_RS12905	COG0084	hydrolase, TatD family'
EP12_RS12950	COG1595	DNA-templated transcription, initiation
EP12_RS12970	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EP12_RS13050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EP12_RS13055	COG1047	Peptidyl-prolyl cis-trans
EP12_RS13070	COG0196	riboflavin kinase activity
EP12_RS13075	COG0728	peptidoglycan biosynthetic process
EP12_RS13080	COG0268	Binds directly to 16S ribosomal RNA
EP12_RS13110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP12_RS13115	COG0776	regulation of translation
EP12_RS13120	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EP12_RS13125	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EP12_RS13130	COG0740	serine-type endopeptidase activity
EP12_RS13135	COG0544	peptidyl-prolyl cis-trans isomerase activity
EP12_RS13175	COG1720	tRNA m6t6A37 methyltransferase activity
EP12_RS13195	COG0123	including yeast histone deacetylase and acetoin utilization protein
EP12_RS13210	COG0517	IMP dehydrogenase activity
EP12_RS13210	COG0516	GMP reductase activity
EP12_RS13215	COG1570	exodeoxyribonuclease VII activity
EP12_RS13230	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP12_RS13235	COG2976	Protein conserved in bacteria
EP12_RS13260	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EP12_RS13270	COG2166	iron-sulfur cluster assembly
EP12_RS13285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EP12_RS13290	COG0719	Fe-S assembly protein
EP12_RS13295	COG0396	ATPase activity
EP12_RS13305	COG1104	cysteine desulfurase activity
EP12_RS13315	COG1045	serine acetyltransferase
EP12_RS13320	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EP12_RS13325	COG0483	inositol monophosphate 1-phosphatase activity
EP12_RS13340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP12_RS13345	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP12_RS13350	COG1862	Preprotein translocase
EP12_RS13355	COG0343	queuine tRNA-ribosyltransferase activity
EP12_RS13375	COG1842	Phage shock protein A
EP12_RS13380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EP12_RS13400	COG0754	glutathionylspermidine amidase activity
EP12_RS13415	COG2066	Belongs to the glutaminase family
EP12_RS13420	COG1785	Belongs to the alkaline phosphatase family
EP12_RS13490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EP12_RS13525	COG0367	asparagine synthase
EP12_RS13530	COG2755	lipolytic protein G-D-S-L family
EP12_RS13530	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EP12_RS13535	COG0438	transferase activity, transferring glycosyl groups
EP12_RS13570	COG1215	transferase activity, transferring glycosyl groups
EP12_RS13580	COG0463	Glycosyl transferase, family 2
EP12_RS13580	COG1216	Glycosyl transferase, family 2
EP12_RS13595	COG0438	transferase activity, transferring glycosyl groups
EP12_RS13600	COG0438	transferase activity, transferring glycosyl groups
EP12_RS13635	COG0489	protein tyrosine kinase activity
EP12_RS13645	COG3267	Type II secretory pathway component ExeA
EP12_RS13645	COG3409	Peptidoglycan-binding domain 1 protein
EP12_RS13655	COG2827	Endonuclease containing a URI domain
EP12_RS13675	COG1560	Kdo2-lipid A biosynthetic process
EP12_RS13685	COG1960	acyl-CoA dehydrogenase activity
EP12_RS13705	COG1435	thymidine kinase activity
EP12_RS13710	COG1609	Transcriptional regulator
EP12_RS13715	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EP12_RS13750	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EP12_RS13755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP12_RS13785	COG1024	Enoyl-CoA hydratase
EP12_RS13785	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP12_RS13800	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EP12_RS13845	COG2080	2 iron, 2 sulfur cluster binding
EP12_RS13850	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EP12_RS13855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EP12_RS13875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EP12_RS13920	COG0693	protein deglycase activity
EP12_RS13945	COG0402	S-adenosylhomocysteine deaminase activity
EP12_RS13955	COG1595	DNA-templated transcription, initiation
EP12_RS13995	COG1295	ribonuclease BN
EP12_RS14000	COG2197	response regulator
EP12_RS14080	COG0477	Major facilitator Superfamily
EP12_RS14090	COG1609	Transcriptional regulator
EP12_RS14090	COG2207	Transcriptional regulator
EP12_RS14105	COG2211	Major facilitator Superfamily
EP12_RS14125	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EP12_RS14130	COG2115	Belongs to the xylose isomerase family
EP12_RS14145	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EP12_RS14185	COG0514	ATP-dependent DNA helicase (RecQ)
EP12_RS14190	COG2267	carboxylic ester hydrolase activity
EP12_RS14210	COG2205	protein histidine kinase activity
EP12_RS14210	COG5002	protein histidine kinase activity
EP12_RS14210	COG0784	Response regulator, receiver
EP12_RS14215	COG1595	DNA-templated transcription, initiation
EP12_RS14220	COG0596	Alpha beta hydrolase
EP12_RS14225	COG1764	response to oxidative stress
EP12_RS14230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EP12_RS14245	COG4555	ABC transporter
EP12_RS14250	COG0513	Belongs to the DEAD box helicase family
EP12_RS14265	COG0235	Class ii aldolase
EP12_RS14285	COG1312	Catalyzes the dehydration of D-mannonate
EP12_RS14300	COG3177	Filamentation induced by cAMP protein fic
EP12_RS14400	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EP12_RS14400	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EP12_RS14415	COG0583	DNA-binding transcription factor activity
EP12_RS14420	COG0006	proline dipeptidase activity
EP12_RS14430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP12_RS14435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP12_RS14440	COG0006	proline dipeptidase activity
EP12_RS14450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP12_RS14460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EP12_RS14465	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EP12_RS14470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP12_RS14510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP12_RS14515	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP12_RS14520	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EP12_RS14540	COG3577	Aspartyl protease
EP12_RS14550	COG4969	Belongs to the N-Me-Phe pilin family
EP12_RS14555	COG1459	type II secretion system
EP12_RS14565	COG0237	dephospho-CoA kinase activity
EP12_RS14570	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EP12_RS14575	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EP12_RS14600	COG2814	Major facilitator Superfamily
EP12_RS14605	COG0702	epimerase
EP12_RS14615	COG3608	succinylglutamate desuccinylase aspartoacylase
EP12_RS14630	COG0739	heme binding
EP12_RS14635	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EP12_RS14640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EP12_RS14645	COG0849	cell division
EP12_RS14650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EP12_RS14655	COG1181	Belongs to the D-alanine--D-alanine ligase family
EP12_RS14660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EP12_RS14670	COG0772	Belongs to the SEDS family
EP12_RS14675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EP12_RS14685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EP12_RS14700	COG3116	cell division
EP12_RS14710	COG2001	Belongs to the MraZ family
EP12_RS14725	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP12_RS14750	COG0678	peroxiredoxin activity
EP12_RS14750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EP12_RS14765	COG2204	response regulator
EP12_RS14780	COG2084	Dehydrogenase
EP12_RS14815	COG0668	transmembrane transport
EP12_RS14825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EP12_RS14835	COG1678	Uncharacterized ACR, COG1678
EP12_RS14840	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EP12_RS14860	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EP12_RS14865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EP12_RS14870	COG0762	integral membrane protein
EP12_RS14910	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EP12_RS14940	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EP12_RS14945	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EP12_RS14950	COG0083	homoserine kinase activity
EP12_RS14960	COG0583	DNA-binding transcription factor activity
EP12_RS14975	COG0640	Transcriptional regulator
EP12_RS14985	COG0431	NADPH-dependent FMN reductase
EP12_RS14990	COG0798	PFAM Bile acid sodium symporter
EP12_RS14995	COG2201	protein-glutamate methylesterase activity
EP12_RS15000	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EP12_RS15010	COG2205	protein histidine kinase activity
EP12_RS15025	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EP12_RS15035	COG1748	Saccharopine dehydrogenase
EP12_RS15055	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EP12_RS15065	COG0792	nuclease activity
EP12_RS15075	COG2823	Periplasmic or secreted lipoprotein
EP12_RS15100	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EP12_RS15105	COG0372	Belongs to the citrate synthase family
EP12_RS15115	COG2828	Protein conserved in bacteria
EP12_RS15120	COG2203	Gaf domain
EP12_RS15120	COG2199	diguanylate cyclase activity
EP12_RS15140	COG5002	protein histidine kinase activity
EP12_RS15140	COG2198	Histidine kinase
EP12_RS15140	COG0784	Response regulator, receiver
EP12_RS15145	COG3023	N-Acetylmuramoyl-L-alanine amidase
EP12_RS15150	COG0070	glutamate synthase
EP12_RS15150	COG0067	glutamate synthase
EP12_RS15150	COG0069	glutamate synthase activity
EP12_RS15155	COG0493	'glutamate synthase
EP12_RS15170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EP12_RS15180	COG2755	lipolytic protein G-D-S-L family
EP12_RS15200	COG3401	FG-GAP repeat protein
EP12_RS15205	COG1304	FMN binding
EP12_RS15210	COG4952	isomerase
EP12_RS15215	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_RS15215	COG3347	Dehydrogenase
EP12_RS15230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP12_RS15235	COG1414	Transcriptional regulator
EP12_RS15240	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_RS15255	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EP12_RS15270	COG3254	rhamnose metabolic process
EP12_RS15285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP12_RS15295	COG5507	3-demethylubiquinone-9 3-methyltransferase
EP12_RS15300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EP12_RS15305	COG0739	heme binding
EP12_RS15305	COG0741	lytic transglycosylase activity
EP12_RS15305	COG1196	nuclear chromosome segregation
EP12_RS15310	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EP12_RS15315	COG3437	response regulator, receiver
EP12_RS15340	COG0625	glutathione transferase activity
EP12_RS15370	COG2894	cell division
EP12_RS15375	COG0850	regulation of cytokinetic process
EP12_RS15405	COG1981	membrane
EP12_RS15420	COG1914	H( )-stimulated, divalent metal cation uptake system
EP12_RS15435	COG1217	gtp-binding protein TYPA
EP12_RS15440	COG0174	glutamine synthetase
EP12_RS15450	COG3852	Histidine kinase
EP12_RS15455	COG2204	response regulator
EP12_RS15460	COG3437	response regulator, receiver
EP12_RS15495	COG0525	valine-tRNA ligase activity
EP12_RS15500	COG2927	DNA polymerase III (CHI subunit)
EP12_RS15505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EP12_RS15520	COG0840	transmembrane signaling receptor activity
EP12_RS15525	COG3588	fructose-bisphosphate aldolase
EP12_RS15555	COG3842	ATPase activity
EP12_RS15560	COG3842	ATPase activity
EP12_RS15565	COG3284	Transcriptional regulator
EP12_RS15570	COG0149	triose-phosphate isomerase activity
EP12_RS15575	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EP12_RS15580	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EP12_RS15590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EP12_RS15595	COG3842	ATPase activity
EP12_RS15610	COG0795	lipopolysaccharide-transporting ATPase activity
EP12_RS15615	COG0795	lipopolysaccharide-transporting ATPase activity
EP12_RS15625	COG1414	Transcriptional regulator
EP12_RS15630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP12_RS15635	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_RS15645	COG3246	L-lysine catabolic process to acetate
EP12_RS15650	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP12_RS15730	COG3250	beta-galactosidase activity
EP12_RS15750	COG4948	Mandelate Racemase Muconate Lactonizing
EP12_RS15755	COG3661	Belongs to the glycosyl hydrolase 67 family
EP12_RS15770	COG0793	Belongs to the peptidase S41A family
EP12_RS15770	COG4946	Tricorn protease homolog
EP12_RS15825	COG4206	TonB-dependent receptor
EP12_RS15830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EP12_RS15835	COG4139	cobalamin transport
EP12_RS15845	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EP12_RS15865	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_RS15880	COG1609	Transcriptional regulator
EP12_RS15900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP12_RS15915	COG2267	carboxylic ester hydrolase activity
EP12_RS15930	COG1116	anion transmembrane transporter activity
EP12_RS15950	COG0513	Belongs to the DEAD box helicase family
EP12_RS15955	COG0800	Aldolase
EP12_RS15960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP12_RS15975	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EP12_RS15975	COG3264	Mechanosensitive ion channel
EP12_RS15980	COG2207	Transcriptional regulator
EP12_RS16000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EP12_RS16000	COG0475	glutathione-regulated potassium exporter activity
EP12_RS16015	COG3568	Endonuclease Exonuclease Phosphatase
EP12_RS16030	COG0730	response to heat
EP12_RS16035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP12_RS16055	COG0417	DNA replication proofreading
EP12_RS16105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP12_RS16115	COG1573	uracil-dna glycosylase
EP12_RS16140	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EP12_RS16165	COG1842	Phage shock protein A
EP12_RS16195	COG4529	Protein conserved in bacteria
EP12_RS16210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EP12_RS16225	COG0204	Acyl-transferase
EP12_RS16230	COG0204	Acyl-transferase
EP12_RS16235	COG0668	transmembrane transport
EP12_RS16250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EP12_RS16255	COG0733	neurotransmitter:sodium symporter activity
EP12_RS16270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EP12_RS16285	COG0716	FMN binding
EP12_RS16295	COG0848	biopolymer transport protein
EP12_RS16305	COG0457	Tetratricopeptide repeat
EP12_RS16310	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EP12_RS16335	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EP12_RS16355	COG5001	Diguanylate cyclase
EP12_RS16355	COG5002	protein histidine kinase activity
EP12_RS16365	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EP12_RS16370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP12_RS16380	COG0583	DNA-binding transcription factor activity
EP12_RS16405	COG0121	glutamine amidotransferase
EP12_RS16430	COG1522	sequence-specific DNA binding
EP12_RS16450	COG0577	efflux transmembrane transporter activity
EP12_RS16450	COG1136	(ABC) transporter
EP12_RS16465	COG4628	conserved protein (DUF2132)
EP12_RS16475	COG3265	gluconokinase activity
EP12_RS16480	COG1609	Transcriptional regulator
EP12_RS16495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EP12_RS16510	COG2871	sodium ion transport
EP12_RS16515	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EP12_RS16520	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EP12_RS16530	COG1805	sodium ion transport
EP12_RS16535	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EP12_RS16540	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EP12_RS16545	COG0545	Peptidyl-prolyl cis-trans isomerase
EP12_RS16550	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EP12_RS16565	COG0039	L-malate dehydrogenase activity
EP12_RS16570	COG1438	arginine binding
EP12_RS16575	COG4206	TonB-dependent receptor
EP12_RS16605	COG0572	uridine kinase
EP12_RS16610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EP12_RS16640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP12_RS16650	COG2198	Histidine kinase
EP12_RS16650	COG0784	Response regulator, receiver
EP12_RS16650	COG5002	protein histidine kinase activity
EP12_RS16660	COG0189	ligase activity
EP12_RS16670	COG4067	protein conserved in archaea
EP12_RS16670	COG0189	ligase activity
EP12_RS16685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EP12_RS16695	COG1283	sodium-dependent phosphate transmembrane transporter activity
EP12_RS16700	COG0667	Aldo Keto reductase
EP12_RS16715	COG0753	catalase activity
EP12_RS16815	COG0583	DNA-binding transcription factor activity
EP12_RS16845	COG0438	transferase activity, transferring glycosyl groups
EP12_RS16845	COG1216	Glycosyl transferase, family 2
EP12_RS16855	COG1091	dTDP-4-dehydrorhamnose reductase activity
EP12_RS16880	COG0463	Glycosyl transferase, family 2
EP12_RS16885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EP12_RS16890	COG0110	maltose O-acetyltransferase activity
EP12_RS16895	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EP12_RS16905	COG0463	Glycosyl transferase, family 2
EP12_RS16920	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EP12_RS16925	COG0473	3-isopropylmalate dehydrogenase activity
EP12_RS16925	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EP12_RS16955	COG0662	Cupin 2, conserved barrel domain protein
EP12_RS16955	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EP12_RS16975	COG0202	RNA polymerase activity
EP12_RS16995	COG0201	protein transport
EP12_RS17015	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EP12_RS17060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP12_RS17080	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EP12_RS17105	COG2234	aminopeptidase activity
EP12_RS17145	COG1271	oxidase subunit
EP12_RS17150	COG1294	oxidase, subunit
EP12_RS17160	COG1278	Cold shock
EP12_RS17165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EP12_RS17185	COG0339	signal peptide processing
EP12_RS17190	COG2201	protein-glutamate methylesterase activity
EP12_RS17200	COG4191	Histidine kinase
EP12_RS17200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP12_RS17210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP12_RS17215	COG0823	Involved in the tonB-independent uptake of proteins
EP12_RS17215	COG1506	peptidase
EP12_RS17215	COG4946	Tricorn protease homolog
EP12_RS17255	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EP12_RS17260	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EP12_RS17265	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EP12_RS17280	COG0281	malic enzyme
EP12_RS17290	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EP12_RS17320	COG0456	acetyltransferase
EP12_RS17340	COG2177	Part of the ABC transporter FtsEX involved in
EP12_RS17345	COG2884	Cell division ATP-binding protein ftsE
EP12_RS17350	COG0552	protein localization to endoplasmic reticulum
EP12_RS17360	COG3068	Protein conserved in bacteria
EP12_RS17365	COG2095	MarC family integral membrane protein
EP12_RS17385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EP12_RS17400	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EP12_RS17415	COG0076	glutamate decarboxylase activity
EP12_RS17430	COG1131	(ABC) transporter
EP12_RS17440	COG0745	RESPONSE REGULATOR receiver
EP12_RS17445	COG2205	protein histidine kinase activity
EP12_RS17450	COG4774	siderophore transport
EP12_RS17470	COG1253	flavin adenine dinucleotide binding
EP12_RS17475	COG0701	Predicted permease
EP12_RS17480	COG1966	Carbon starvation protein
EP12_RS17490	COG0657	acetylesterase activity
EP12_RS17525	COG0049	tRNA binding
EP12_RS17530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EP12_RS17540	COG0085	RNA polymerase activity
EP12_RS17550	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EP12_RS17560	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EP12_RS17575	COG0250	Participates in transcription elongation, termination and antitermination
EP12_RS17580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EP12_RS17605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EP12_RS17625	COG0418	dihydroorotase activity
EP12_RS17635	COG3040	lipid binding
EP12_RS17640	COG4989	oxidoreductase activity
EP12_RS17645	COG0346	lactoylglutathione lyase activity
EP12_RS17660	COG0302	gtp cyclohydrolase
EP12_RS17670	COG2957	Belongs to the agmatine deiminase family
EP12_RS17675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP12_RS17685	COG3706	GGDEF domain
EP12_RS17695	COG2207	Transcriptional regulator
EP12_RS17745	COG1201	RNA secondary structure unwinding
EP12_RS17755	COG1793	dna ligase
EP12_RS17775	COG0625	glutathione transferase activity
EP12_RS17785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EP12_RS17795	COG1012	belongs to the aldehyde dehydrogenase family
EP12_RS17810	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EP12_RS17825	COG0330	HflC and HflK could
EP12_RS17830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EP12_RS17835	COG1923	regulation of RNA biosynthetic process
EP12_RS17840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EP12_RS17855	COG0802	atpase or kinase
EP12_RS17865	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EP12_RS17885	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EP12_RS17890	COG0735	belongs to the Fur family
EP12_RS17900	COG0432	Pfam Uncharacterised protein family UPF0047
EP12_RS17955	COG5002	protein histidine kinase activity
EP12_RS17985	COG1609	Transcriptional regulator
EP12_RS17995	COG2723	6-phospho-beta-galactosidase activity
EP12_RS18015	COG0789	Transcriptional regulator
EP12_RS18035	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EP12_RS18040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EP12_RS18045	COG4558	Periplasmic binding protein
EP12_RS18055	COG4771	TonB-dependent receptor
EP12_RS18080	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EP12_RS18085	COG4988	ABC transporter
EP12_RS18095	COG1294	oxidase, subunit
EP12_RS18205	COG3237	CsbD-like
EP12_RS18220	COG4771	TonB-dependent receptor
EP12_RS18225	COG0457	Tetratricopeptide repeat
EP12_RS18245	COG3314	Sporulation integral membrane protein YlbJ
EP12_RS18260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EP12_RS18320	COG1595	DNA-templated transcription, initiation
EP12_RS18350	COG2267	carboxylic ester hydrolase activity
EP12_RS18400	COG2130	NADP-dependent
EP12_RS18435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EP12_RS18445	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP12_RS18465	COG0656	L-ascorbic acid biosynthetic process
EP12_RS18470	COG2175	clavaminate synthase activity
EP12_RS18475	COG2855	membrane
EP12_RS18510	COG1349	DNA-binding transcription factor activity
EP12_RS18515	COG0673	inositol 2-dehydrogenase activity
EP12_RS18540	COG2169	Transcriptional regulator
EP12_RS18600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP12_RS18610	COG0109	protoheme IX farnesyltransferase activity
EP12_RS18645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EP12_RS18675	COG1335	isochorismatase
EP12_RS18680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP12_RS18695	COG3384	dioxygenase
EP12_RS18705	COG2175	clavaminate synthase activity
EP12_RS18725	COG1324	tolerance protein
EP12_RS18735	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EP12_RS18740	COG0511	ligase activity, forming carbon-carbon bonds
EP12_RS18745	COG0439	Biotin carboxylase
EP12_RS18815	COG0151	Belongs to the GarS family
EP12_RS18865	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EP12_RS18895	COG2165	general secretion pathway protein
EP12_RS18910	COG4795	General secretion pathway protein
EP12_RS18925	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EP12_RS18940	COG1012	belongs to the aldehyde dehydrogenase family
EP12_RS18950	COG1011	Hydrolase
EP12_RS18975	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EP12_RS18985	COG3089	Belongs to the UPF0270 family
EP12_RS19025	COG0545	Peptidyl-prolyl cis-trans isomerase
EP12_RS19035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EP12_RS19060	COG1040	competence protein
EP12_RS19080	COG1794	racemase activity, acting on amino acids and derivatives
EP12_RS19085	COG2226	methyltransferase
EP12_RS19100	COG0534	Mate efflux family protein
EP12_RS19120	COG0109	protoheme IX farnesyltransferase activity
EP12_RS19170	COG4774	siderophore transport
EP12_RS19195	COG2860	membrane
EP12_RS19205	COG0583	DNA-binding transcription factor activity
EP12_RS19215	COG2814	Major facilitator Superfamily
EP12_RS19220	COG0729	surface antigen
EP12_RS19245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EP12_RS19320	COG0425	Belongs to the sulfur carrier protein TusA family
EP12_RS19360	COG0582	viral genome integration into host DNA
EP12_RS19365	COG2003	Belongs to the UPF0758 family
EP12_RS19400	COG0210	DNA helicase
EP12_RS19490	COG2211	Major facilitator Superfamily
EP12_RS19540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EP12_RS19560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EP12_RS19565	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EP12_RS19585	COG1475	DNA binding
EP12_RS19590	COG1192	Involved in chromosome partitioning
EP12_RS19615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EP12_RS19620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EP12_RS19630	COG0706	membrane insertase activity
EP12_RS19635	COG0594	ribonuclease P activity
EP12_RS19670	COG3437	response regulator, receiver
EP12_RS19710	COG0741	lytic transglycosylase activity
EP12_RS19720	COG3209	COG3209 Rhs family protein
EP12_RS19780	COG3646	Phage regulatory protein
EP12_RS19790	COG1073	alpha beta
EP12_RS19790	COG2226	methyltransferase
EP12_RS19840	COG4977	sequence-specific DNA binding
EP12_RS19855	COG0515	serine threonine protein kinase
EP12_RS19855	COG2815	serine threonine protein kinase
EP12_RS19875	COG3437	response regulator, receiver
EP12_RS19875	COG3850	Histidine kinase
EP12_RS19875	COG4999	Histidine kinase
EP12_RS19875	COG2205	protein histidine kinase activity
EP12_RS19890	COG1203	CRISPR-associated helicase, Cas3
EP12_RS19895	COG1203	CRISPR-associated helicase, Cas3
EP12_RS19900	COG1203	CRISPR-associated helicase, Cas3
EP12_RS19910	COG5002	protein histidine kinase activity
EP12_RS19910	COG0784	Response regulator, receiver
EP12_RS19910	COG2205	protein histidine kinase activity
EP12_RS19935	COG1215	transferase activity, transferring glycosyl groups
EP12_RS19965	COG0655	NAD(P)H dehydrogenase (quinone) activity
EP12_RS19995	COG4638	Rieske (2fe-2S)