locus-tag	class	description
EP13_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EP13_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EP13_RS00040	COG2818	Glycosylase
EP13_RS00050	COG3078	GTPase activator activity
EP13_RS00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EP13_RS00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EP13_RS00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EP13_RS00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EP13_RS00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EP13_RS00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EP13_RS00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EP13_RS00105	COG1652	LysM domain
EP13_RS00110	COG0758	DNA mediated transformation
EP13_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
EP13_RS00130	COG0408	coproporphyrinogen oxidase activity
EP13_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EP13_RS00220	COG2234	aminopeptidase activity
EP13_RS00225	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EP13_RS00245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EP13_RS00270	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP13_RS00300	COG3642	lipopolysaccharide core region biosynthetic process
EP13_RS00305	COG0859	PFAM glycosyl transferase family 9
EP13_RS00325	COG0156	8-amino-7-oxononanoate synthase activity
EP13_RS00335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP13_RS00340	COG0705	Rhomboid family
EP13_RS00350	COG3161	chorismate lyase activity
EP13_RS00355	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EP13_RS00360	COG2960	long-chain fatty acid transporting porin activity
EP13_RS00365	COG0210	DNA helicase
EP13_RS00455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP13_RS00460	COG0842	Transport permease protein
EP13_RS00460	COG1129	ABC transporter
EP13_RS00465	COG0842	Transport permease protein
EP13_RS00470	COG4773	Receptor
EP13_RS00475	COG4771	TonB-dependent receptor
EP13_RS00480	COG1960	acyl-CoA dehydrogenase activity
EP13_RS00485	COG0583	DNA-binding transcription factor activity
EP13_RS00495	COG3106	COG3106 Predicted ATPase
EP13_RS00510	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EP13_RS00530	COG0352	thiamine-phosphate diphosphorylase activity
EP13_RS00540	COG4771	TonB-dependent receptor
EP13_RS00555	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
EP13_RS00555	COG0778	Nitroreductase
EP13_RS00565	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EP13_RS00570	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EP13_RS00575	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EP13_RS00580	COG1309	transcriptional regulator
EP13_RS00605	COG1953	Uracil, thiamine, allantoin
EP13_RS00615	COG3071	HemY protein
EP13_RS00620	COG2959	enzyme of heme biosynthesis
EP13_RS00625	COG1587	Uroporphyrinogen-III synthase
EP13_RS00630	COG0181	hydroxymethylbilane synthase activity
EP13_RS00645	COG0194	GDP metabolic process
EP13_RS00655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP13_RS00665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP13_RS00670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EP13_RS00680	COG0678	peroxiredoxin activity
EP13_RS00695	COG1178	ABC-type Fe3 transport system permease component
EP13_RS00700	COG3842	ATPase activity
EP13_RS00705	COG0668	transmembrane transport
EP13_RS00710	COG2081	HI0933 family
EP13_RS00720	COG4774	siderophore transport
EP13_RS00735	COG0745	RESPONSE REGULATOR receiver
EP13_RS00740	COG0457	Tetratricopeptide repeat
EP13_RS00765	COG0010	Belongs to the arginase family
EP13_RS00770	COG0010	Belongs to the arginase family
EP13_RS00775	COG5002	protein histidine kinase activity
EP13_RS00775	COG2198	Histidine kinase
EP13_RS00775	COG0784	Response regulator, receiver
EP13_RS00790	COG1172	Belongs to the binding-protein-dependent transport system permease family
EP13_RS00805	COG0829	nickel cation binding
EP13_RS00810	COG0831	urea catabolic process
EP13_RS00830	COG0830	nickel cation binding
EP13_RS00880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP13_RS00895	COG0427	acetyl-CoA hydrolase
EP13_RS00900	COG0123	including yeast histone deacetylase and acetoin utilization protein
EP13_RS00925	COG3064	Membrane
EP13_RS00935	COG5001	Diguanylate cyclase
EP13_RS00935	COG5002	protein histidine kinase activity
EP13_RS00950	COG0514	ATP-dependent DNA helicase (RecQ)
EP13_RS00960	COG2239	Acts as a magnesium transporter
EP13_RS00965	COG2962	Rard protein
EP13_RS00975	COG0210	DNA helicase
EP13_RS00985	COG1011	Hydrolase
EP13_RS01000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EP13_RS01005	COG0019	diaminopimelate decarboxylase activity
EP13_RS01035	COG0163	prenyltransferase activity
EP13_RS01040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EP13_RS01050	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EP13_RS01075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EP13_RS01080	COG2814	Major facilitator Superfamily
EP13_RS01085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP13_RS01115	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EP13_RS01125	COG0629	single-stranded DNA binding
EP13_RS01155	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP13_RS01170	COG1349	DNA-binding transcription factor activity
EP13_RS01190	COG1077	Cell shape determining protein MreB Mrl
EP13_RS01195	COG1792	Involved in formation and maintenance of cell shape
EP13_RS01200	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EP13_RS01205	COG0424	maF-like protein
EP13_RS01210	COG1530	ribonuclease E activity
EP13_RS01215	COG3164	Protein of unknown function
EP13_RS01220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP13_RS01225	COG0312	modulator of DNA gyrase
EP13_RS01230	COG3028	Belongs to the UPF0307 family
EP13_RS01235	COG0312	modulator of DNA gyrase
EP13_RS01250	COG0745	RESPONSE REGULATOR receiver
EP13_RS01255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP13_RS01255	COG4191	Histidine kinase
EP13_RS01260	COG0297	glycogen (starch) synthase activity
EP13_RS01270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EP13_RS01330	COG0328	RNA-DNA hybrid ribonuclease activity
EP13_RS01330	COG3341	Caulimovirus viroplasmin
EP13_RS01350	COG4974	Belongs to the 'phage' integrase family
EP13_RS01380	COG5002	protein histidine kinase activity
EP13_RS01385	COG0745	RESPONSE REGULATOR receiver
EP13_RS01405	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP13_RS01475	COG1017	nitric oxide dioxygenase activity
EP13_RS01475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EP13_RS01495	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EP13_RS01525	COG0375	protein maturation
EP13_RS01535	COG0409	Hydrogenase expression formation protein
EP13_RS01540	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EP13_RS01545	COG0309	Hydrogenase expression formation protein (HypE)
EP13_RS01550	COG0789	Transcriptional regulator
EP13_RS01555	COG2217	Heavy metal translocating P-type atpase
EP13_RS01630	COG0531	amino acid
EP13_RS01640	COG2132	Multicopper oxidase
EP13_RS01665	COG4771	TonB-dependent receptor
EP13_RS01705	COG2378	regulation of single-species biofilm formation
EP13_RS01715	COG4771	TonB-dependent receptor
EP13_RS01735	COG0583	DNA-binding transcription factor activity
EP13_RS01740	COG2814	Major facilitator Superfamily
EP13_RS01745	COG0840	transmembrane signaling receptor activity
EP13_RS01750	COG0745	RESPONSE REGULATOR receiver
EP13_RS01755	COG2198	Histidine kinase
EP13_RS01755	COG0643	Histidine kinase
EP13_RS01760	COG0835	chemotaxis
EP13_RS01775	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EP13_RS01805	COG3437	response regulator, receiver
EP13_RS01810	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EP13_RS01825	COG1609	Transcriptional regulator
EP13_RS01830	COG0673	inositol 2-dehydrogenase activity
EP13_RS01840	COG2211	Major facilitator Superfamily
EP13_RS01845	COG1082	Xylose isomerase domain protein TIM barrel
EP13_RS01895	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EP13_RS01900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EP13_RS01905	COG0051	transcription antitermination factor activity, RNA binding
EP13_RS01920	COG0089	rRNA binding
EP13_RS01930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EP13_RS01940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EP13_RS01955	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EP13_RS01960	COG0438	transferase activity, transferring glycosyl groups
EP13_RS01970	COG1519	Transferase
EP13_RS02005	COG0788	formyltetrahydrofolate deformylase activity
EP13_RS02020	COG1643	Atp-dependent helicase
EP13_RS02025	COG2951	lytic endotransglycosylase activity
EP13_RS02035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EP13_RS02045	COG2354	Protein conserved in bacteria
EP13_RS02050	COG2169	Transcriptional regulator
EP13_RS02070	COG0004	ammonium transporteR
EP13_RS02075	COG0405	Gamma-glutamyltransferase
EP13_RS02080	COG2837	iron assimilation
EP13_RS02090	COG0540	Belongs to the ATCase OTCase family
EP13_RS02130	COG3300	MHYT domain
EP13_RS02130	COG5001	Diguanylate cyclase
EP13_RS02140	COG1012	belongs to the aldehyde dehydrogenase family
EP13_RS02150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EP13_RS02160	COG0512	Glutamine amidotransferase of anthranilate synthase
EP13_RS02165	COG0180	Tryptophanyl-tRNA synthetase
EP13_RS02170	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EP13_RS02190	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EP13_RS02200	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EP13_RS02235	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EP13_RS02240	COG0281	malic enzyme
EP13_RS02245	COG0625	glutathione transferase activity
EP13_RS02250	COG0753	catalase activity
EP13_RS02270	COG3300	MHYT domain
EP13_RS02270	COG5001	Diguanylate cyclase
EP13_RS02275	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EP13_RS02275	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EP13_RS02285	COG0137	argininosuccinate synthase activity
EP13_RS02305	COG1803	Methylglyoxal synthase
EP13_RS02315	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EP13_RS02330	COG0745	RESPONSE REGULATOR receiver
EP13_RS02335	COG2205	protein histidine kinase activity
EP13_RS02340	COG2267	carboxylic ester hydrolase activity
EP13_RS02345	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EP13_RS02355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EP13_RS02365	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EP13_RS02370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP13_RS02375	COG4942	peptidase
EP13_RS02385	COG2861	carbohydrate metabolic process
EP13_RS02410	COG1162	GTPase activity
EP13_RS02415	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EP13_RS02445	COG0028	Belongs to the TPP enzyme family
EP13_RS02465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EP13_RS02470	COG0805	protein transport
EP13_RS02485	COG3706	GGDEF domain
EP13_RS02495	COG0248	Ppx GppA phosphatase
EP13_RS02500	COG0513	Belongs to the DEAD box helicase family
EP13_RS02505	COG3118	belongs to the thioredoxin family
EP13_RS02510	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EP13_RS02515	COG1473	amidohydrolase
EP13_RS02520	COG0784	Response regulator, receiver
EP13_RS02520	COG2205	protein histidine kinase activity
EP13_RS02525	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EP13_RS02530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EP13_RS02535	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EP13_RS02550	COG0783	Belongs to the Dps family
EP13_RS02555	COG2133	pyrroloquinoline quinone binding
EP13_RS02560	COG1506	peptidase
EP13_RS02560	COG0823	Involved in the tonB-independent uptake of proteins
EP13_RS02560	COG4946	Tricorn protease homolog
EP13_RS02570	COG3118	belongs to the thioredoxin family
EP13_RS02580	COG1012	belongs to the aldehyde dehydrogenase family
EP13_RS02590	COG1757	Na H antiporter
EP13_RS02605	COG3876	Protein conserved in bacteria
EP13_RS02610	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EP13_RS02695	COG1247	-acetyltransferase
EP13_RS02715	COG0519	Catalyzes the synthesis of GMP from XMP
EP13_RS02750	COG1228	amidohydrolase
EP13_RS02785	COG0183	Belongs to the thiolase family
EP13_RS02790	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP13_RS02790	COG1024	Enoyl-CoA hydratase
EP13_RS02795	COG0741	lytic transglycosylase activity
EP13_RS02800	COG0006	proline dipeptidase activity
EP13_RS02810	COG0142	geranyltranstransferase activity
EP13_RS02860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EP13_RS02865	COG4942	peptidase
EP13_RS02865	COG1388	LysM domain
EP13_RS02870	COG1238	metal cluster binding
EP13_RS02880	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EP13_RS02885	COG0585	pseudouridine synthase activity
EP13_RS02900	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EP13_RS02910	COG0840	transmembrane signaling receptor activity
EP13_RS02920	COG1538	Outer membrane efflux protein
EP13_RS02930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP13_RS02950	COG3025	triphosphatase activity
EP13_RS02960	COG3066	DNA modification
EP13_RS02965	COG0494	nUDIX hydrolase
EP13_RS02975	COG0730	response to heat
EP13_RS02980	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EP13_RS02985	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EP13_RS02995	COG3706	GGDEF domain
EP13_RS03000	COG2205	protein histidine kinase activity
EP13_RS03000	COG0784	Response regulator, receiver
EP13_RS03020	COG0564	pseudouridine synthase activity
EP13_RS03025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EP13_RS03030	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EP13_RS03040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EP13_RS03040	COG1648	precorrin-2 dehydrogenase activity
EP13_RS03065	COG1538	Outer membrane efflux protein
EP13_RS03070	COG0494	nUDIX hydrolase
EP13_RS03075	COG3151	Protein conserved in bacteria
EP13_RS03085	COG3150	esterase
EP13_RS03090	COG0187	DNA topoisomerase II activity
EP13_RS03100	COG4251	negative regulation of phosphorylation
EP13_RS03105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP13_RS03125	COG1509	lysine 2,3-aminomutase activity
EP13_RS03130	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EP13_RS03135	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EP13_RS03150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EP13_RS03165	COG0271	Belongs to the BolA IbaG family
EP13_RS03170	COG0671	phosphoesterase, PA-phosphatase related
EP13_RS03180	COG3707	response regulator
EP13_RS03190	COG0659	secondary active sulfate transmembrane transporter activity
EP13_RS03195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP13_RS03200	COG2146	nitrite reductase [NAD(P)H] activity
EP13_RS03205	COG0243	molybdopterin cofactor binding
EP13_RS03210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EP13_RS03210	COG1648	precorrin-2 dehydrogenase activity
EP13_RS03215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EP13_RS03225	COG1116	anion transmembrane transporter activity
EP13_RS03225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EP13_RS03230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP13_RS03235	COG1116	anion transmembrane transporter activity
EP13_RS03245	COG0746	molybdenum cofactor guanylyltransferase activity
EP13_RS03255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EP13_RS03260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EP13_RS03265	COG0348	domain, Protein
EP13_RS03280	COG1960	acyl-CoA dehydrogenase activity
EP13_RS03285	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_RS03295	COG4948	Mandelate Racemase Muconate Lactonizing
EP13_RS03315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP13_RS03355	COG0358	DNA primase activity
EP13_RS03375	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EP13_RS03395	COG0537	adenosine 5'-monophosphoramidase activity
EP13_RS03410	COG3135	benzoate transporter
EP13_RS03415	COG1396	sequence-specific DNA binding
EP13_RS03420	COG2974	May be involved in recombination
EP13_RS03425	COG4191	Histidine kinase
EP13_RS03425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP13_RS03430	COG0745	RESPONSE REGULATOR receiver
EP13_RS03435	COG5002	protein histidine kinase activity
EP13_RS03465	COG0811	peptide transport
EP13_RS03470	COG0811	peptide transport
EP13_RS03475	COG0848	biopolymer transport protein
EP13_RS03480	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EP13_RS03490	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EP13_RS03495	COG3437	response regulator, receiver
EP13_RS03500	COG2205	protein histidine kinase activity
EP13_RS03500	COG0784	Response regulator, receiver
EP13_RS03500	COG5002	protein histidine kinase activity
EP13_RS03515	COG2133	pyrroloquinoline quinone binding
EP13_RS03530	COG1793	dna ligase
EP13_RS03545	COG0527	aspartate kinase activity
EP13_RS03550	COG0840	transmembrane signaling receptor activity
EP13_RS03555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EP13_RS03560	COG2967	ApaG domain
EP13_RS03565	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EP13_RS03570	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EP13_RS03575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP13_RS03580	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EP13_RS03585	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EP13_RS03595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EP13_RS03600	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EP13_RS03615	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EP13_RS03625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EP13_RS03630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP13_RS03635	COG3956	TIGRFAM MazG family protein
EP13_RS03650	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EP13_RS03655	COG1595	DNA-templated transcription, initiation
EP13_RS03675	COG0723	plastoquinol--plastocyanin reductase activity
EP13_RS03680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EP13_RS03685	COG2857	Cytochrome c1
EP13_RS03690	COG0625	glutathione transferase activity
EP13_RS03695	COG2969	positive regulation of protein catabolic process
EP13_RS03710	COG0745	RESPONSE REGULATOR receiver
EP13_RS03715	COG2239	Acts as a magnesium transporter
EP13_RS03720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EP13_RS03740	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EP13_RS03745	COG1137	ATPase activity
EP13_RS03760	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EP13_RS03775	COG1127	ABC transporter
EP13_RS03780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EP13_RS03785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EP13_RS03790	COG2854	intermembrane phospholipid transfer
EP13_RS03800	COG5007	Belongs to the BolA IbaG family
EP13_RS03810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP13_RS03815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP13_RS03825	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EP13_RS03925	COG0784	Response regulator, receiver
EP13_RS03925	COG2205	protein histidine kinase activity
EP13_RS03925	COG2198	Histidine kinase
EP13_RS03925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP13_RS03940	COG1979	alcohol dehydrogenase
EP13_RS03965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EP13_RS03975	COG0126	phosphoglycerate kinase activity
EP13_RS03980	COG3588	fructose-bisphosphate aldolase
EP13_RS03985	COG0248	Ppx GppA phosphatase
EP13_RS03990	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EP13_RS04000	COG0573	inorganic phosphate transmembrane transporter activity
EP13_RS04010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EP13_RS04020	COG0306	phosphate transporter
EP13_RS04025	COG0589	response to stress
EP13_RS04030	COG0583	DNA-binding transcription factor activity
EP13_RS04040	COG1272	protein, Hemolysin III
EP13_RS04045	COG1846	Transcriptional regulator
EP13_RS04050	COG1764	response to oxidative stress
EP13_RS04060	COG1739	Uncharacterized protein family UPF0029
EP13_RS04070	COG0420	3'-5' exonuclease activity
EP13_RS04075	COG0419	ATPase involved in DNA repair
EP13_RS04105	COG0625	glutathione transferase activity
EP13_RS04130	COG2971	BadF BadG BcrA BcrD
EP13_RS04140	COG0488	(ABC) transporter
EP13_RS04155	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EP13_RS04160	COG0668	transmembrane transport
EP13_RS04195	COG1609	Transcriptional regulator
EP13_RS04230	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EP13_RS04235	COG0732	type I restriction modification DNA specificity domain
EP13_RS04245	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EP13_RS04290	COG1380	Effector of murein hydrolase LrgA
EP13_RS04295	COG1346	cytolysis
EP13_RS04325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EP13_RS04330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EP13_RS04335	COG0513	Belongs to the DEAD box helicase family
EP13_RS04345	COG3267	Type II secretory pathway component ExeA
EP13_RS04345	COG3409	Peptidoglycan-binding domain 1 protein
EP13_RS04360	COG0066	3-isopropylmalate dehydratase activity
EP13_RS04370	COG0473	3-isopropylmalate dehydrogenase activity
EP13_RS04375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EP13_RS04400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EP13_RS04420	COG4555	ABC transporter
EP13_RS04425	COG1668	transmembrane transport
EP13_RS04440	COG4133	protoheme IX ABC transporter activity
EP13_RS04445	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP13_RS04450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP13_RS04455	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP13_RS04465	COG1138	Cytochrome C-type biogenesis protein
EP13_RS04470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EP13_RS04485	COG2853	Lipoprotein
EP13_RS04490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EP13_RS04530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EP13_RS04535	COG0463	Glycosyl transferase, family 2
EP13_RS04535	COG1216	Glycosyl transferase, family 2
EP13_RS04545	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EP13_RS04550	COG1555	photosystem II stabilization
EP13_RS04550	COG1596	polysaccharide export
EP13_RS04555	COG0473	3-isopropylmalate dehydrogenase activity
EP13_RS04570	COG1611	Belongs to the LOG family
EP13_RS04580	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EP13_RS04580	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EP13_RS04635	COG0564	pseudouridine synthase activity
EP13_RS04650	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EP13_RS04655	COG0024	Methionine aminopeptidase
EP13_RS04660	COG0052	Belongs to the universal ribosomal protein uS2 family
EP13_RS04670	COG0528	UMP kinase activity
EP13_RS04680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EP13_RS04685	COG0575	Belongs to the CDS family
EP13_RS04695	COG0750	zinc metalloprotease
EP13_RS04710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EP13_RS04715	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP13_RS04730	COG0587	DNA-directed DNA polymerase activity
EP13_RS04735	COG0825	malonyl-CoA metabolic process
EP13_RS04740	COG0037	tRNA processing
EP13_RS04770	COG0047	phosphoribosylformylglycinamidine synthase activity
EP13_RS04770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EP13_RS04775	COG2840	Smr protein MutS2
EP13_RS04800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP13_RS04805	COG2197	response regulator
EP13_RS04845	COG0835	chemotaxis
EP13_RS04845	COG0784	Response regulator, receiver
EP13_RS04850	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EP13_RS04855	COG1815	bacterial-type flagellum-dependent cell motility
EP13_RS04875	COG4787	bacterial-type flagellum-dependent cell motility
EP13_RS04895	COG3951	Flagellar rod assembly protein muramidase FlgJ
EP13_RS04895	COG1705	Flagellar rod assembly protein muramidase FlgJ
EP13_RS04900	COG1256	bacterial-type flagellum assembly
EP13_RS04920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP13_RS04925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP13_RS04930	COG1334	flagellar protein FlaG
EP13_RS04940	COG1516	flagellar protein fliS
EP13_RS04950	COG1086	Polysaccharide biosynthesis protein
EP13_RS04955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EP13_RS04960	COG1083	cytidylyl-transferase
EP13_RS04965	COG2089	acid synthase
EP13_RS04985	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_RS05015	COG1442	glycosyl transferase family 8
EP13_RS05020	COG1216	Glycosyl transferase, family 2
EP13_RS05055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EP13_RS05085	COG1677	Flagellar hook-basal body complex protein FliE
EP13_RS05090	COG1766	The M ring may be actively involved in energy transduction
EP13_RS05095	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EP13_RS05145	COG1987	bacterial-type flagellum assembly
EP13_RS05160	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EP13_RS05185	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EP13_RS05190	COG0643	Histidine kinase
EP13_RS05190	COG2198	Histidine kinase
EP13_RS05190	COG0784	Response regulator, receiver
EP13_RS05195	COG2201	protein-glutamate methylesterase activity
EP13_RS05200	COG1192	Involved in chromosome partitioning
EP13_RS05210	COG0835	chemotaxis
EP13_RS05240	COG3123	guanosine phosphorylase activity
EP13_RS05245	COG0583	DNA-binding transcription factor activity
EP13_RS05250	COG0583	DNA-binding transcription factor activity
EP13_RS05255	COG0288	reversible hydration of carbon dioxide
EP13_RS05260	COG0659	secondary active sulfate transmembrane transporter activity
EP13_RS05275	COG2137	regulation of response to DNA damage stimulus
EP13_RS05280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EP13_RS05315	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EP13_RS05320	COG4172	Belongs to the ABC transporter superfamily
EP13_RS05325	COG4172	Belongs to the ABC transporter superfamily
EP13_RS05330	COG4171	peptide transport system, permease
EP13_RS05335	COG0601	transmembrane transport
EP13_RS05340	COG0747	negative chemotaxis
EP13_RS05345	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EP13_RS05350	COG1842	Phage shock protein A
EP13_RS05380	COG0625	glutathione transferase activity
EP13_RS05385	COG1522	sequence-specific DNA binding
EP13_RS05415	COG0811	peptide transport
EP13_RS05420	COG0811	peptide transport
EP13_RS05425	COG0848	biopolymer transport protein
EP13_RS05480	COG0456	acetyltransferase
EP13_RS05495	COG0583	DNA-binding transcription factor activity
EP13_RS05500	COG2814	Major facilitator Superfamily
EP13_RS05505	COG0656	L-ascorbic acid biosynthetic process
EP13_RS05545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EP13_RS05555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EP13_RS05570	COG0633	Ferredoxin
EP13_RS05570	COG0543	2 iron, 2 sulfur cluster binding
EP13_RS05690	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_RS05765	COG3547	Transposase (IS116 IS110 IS902 family)
EP13_RS05855	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EP13_RS05860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EP13_RS05865	COG0564	pseudouridine synthase activity
EP13_RS05875	COG0612	Peptidase, M16
EP13_RS05880	COG2918	glutathione biosynthetic process
EP13_RS05890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP13_RS05895	COG1136	(ABC) transporter
EP13_RS05905	COG1136	(ABC) transporter
EP13_RS05905	COG0577	efflux transmembrane transporter activity
EP13_RS05920	COG2840	Smr protein MutS2
EP13_RS05925	COG2890	protein-(glutamine-N5) methyltransferase activity
EP13_RS05945	COG2719	SpoVR family
EP13_RS05950	COG2718	Belongs to the UPF0229 family
EP13_RS05955	COG2766	serine protein kinase
EP13_RS05960	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EP13_RS05965	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EP13_RS05970	COG4771	TonB-dependent receptor
EP13_RS05995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EP13_RS06000	COG2885	chlorophyll binding
EP13_RS06005	COG0584	glycerophosphoryl diester phosphodiesterase
EP13_RS06010	COG0346	lactoylglutathione lyase activity
EP13_RS06015	COG1278	Cold shock
EP13_RS06025	COG3706	GGDEF domain
EP13_RS06030	COG3710	Transcriptional regulator
EP13_RS06075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EP13_RS06110	COG2808	Putative FMN-binding domain
EP13_RS06115	COG0583	DNA-binding transcription factor activity
EP13_RS06120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EP13_RS06125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EP13_RS06130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EP13_RS06135	COG4660	Part of a membrane complex involved in electron transport
EP13_RS06140	COG4659	FMN binding
EP13_RS06145	COG4658	electron transport chain
EP13_RS06150	COG4656	Part of a membrane complex involved in electron transport
EP13_RS06155	COG2878	Part of a membrane complex involved in electron transport
EP13_RS06160	COG4657	Part of a membrane complex involved in electron transport
EP13_RS06175	COG0534	Mate efflux family protein
EP13_RS06180	COG0556	nucleotide-excision repair
EP13_RS06205	COG0602	queuosine metabolic process
EP13_RS06215	COG0367	asparagine synthase
EP13_RS06240	COG3273	potassium ion transport
EP13_RS06240	COG0471	metal ion transport
EP13_RS06255	COG0529	Catalyzes the synthesis of activated sulfate
EP13_RS06260	COG0175	sulfate reduction
EP13_RS06265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP13_RS06280	COG1595	DNA-templated transcription, initiation
EP13_RS06295	COG2304	oxidoreductase activity
EP13_RS06315	COG0714	Associated with various cellular activities
EP13_RS06325	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP13_RS06325	COG1024	Enoyl-CoA hydratase
EP13_RS06340	COG1025	Belongs to the peptidase M16 family
EP13_RS06345	COG2062	phosphohistidine phosphatase, SixA
EP13_RS06355	COG4536	flavin adenine dinucleotide binding
EP13_RS06360	COG4137	Cytochrome C assembly protein
EP13_RS06370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EP13_RS06410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP13_RS06415	COG1132	(ABC) transporter
EP13_RS06420	COG2873	o-acetylhomoserine
EP13_RS06435	COG0228	four-way junction DNA binding
EP13_RS06440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EP13_RS06445	COG0336	Belongs to the RNA methyltransferase TrmD family
EP13_RS06450	COG0335	large ribosomal subunit rRNA binding
EP13_RS06455	COG2860	membrane
EP13_RS06465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EP13_RS06470	COG1605	Chorismate mutase
EP13_RS06470	COG0287	Prephenate dehydrogenase
EP13_RS06475	COG0077	Prephenate dehydratase
EP13_RS06475	COG1605	Chorismate mutase
EP13_RS06480	COG0745	RESPONSE REGULATOR receiver
EP13_RS06485	COG0023	Translation Initiation Factor
EP13_RS06515	COG2205	protein histidine kinase activity
EP13_RS06525	COG2204	response regulator
EP13_RS06530	COG1801	Protein of unknown function DUF72
EP13_RS06535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EP13_RS06540	COG0494	nUDIX hydrolase
EP13_RS06545	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EP13_RS06550	COG0632	four-way junction helicase activity
EP13_RS06555	COG2255	four-way junction helicase activity
EP13_RS06560	COG0824	Thioesterase
EP13_RS06565	COG0811	peptide transport
EP13_RS06580	COG0823	Involved in the tonB-independent uptake of proteins
EP13_RS06585	COG2885	chlorophyll binding
EP13_RS06590	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EP13_RS06610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EP13_RS06620	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_RS06630	COG1451	nucleotide metabolic process
EP13_RS06645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP13_RS06650	COG4667	esterase of the alpha-beta hydrolase superfamily
EP13_RS06655	COG0612	Peptidase, M16
EP13_RS06675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP13_RS06680	COG4221	oxidoreductase activity
EP13_RS06685	COG0753	catalase activity
EP13_RS06690	COG3038	cytochrome b561
EP13_RS06695	COG0583	DNA-binding transcription factor activity
EP13_RS06700	COG4221	oxidoreductase activity
EP13_RS06700	COG0604	alcohol dehydrogenase
EP13_RS06700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EP13_RS06700	COG3321	synthase
EP13_RS06745	COG3008	intermembrane lipid transfer
EP13_RS06745	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EP13_RS06750	COG2995	paraquat-inducible protein a
EP13_RS06770	COG3093	addiction module antidote protein HigA
EP13_RS06775	COG0789	Transcriptional regulator
EP13_RS06815	COG0017	Asparaginyl-tRNA synthetase
EP13_RS06830	COG0189	ligase activity
EP13_RS06865	COG1073	alpha beta
EP13_RS06865	COG2226	methyltransferase
EP13_RS06875	COG3340	Belongs to the peptidase S51 family
EP13_RS06880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EP13_RS06885	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EP13_RS06895	COG1131	(ABC) transporter
EP13_RS06900	COG2972	Histidine kinase
EP13_RS06915	COG5265	(ABC) transporter
EP13_RS06920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EP13_RS06950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EP13_RS06985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP13_RS06990	COG0402	S-adenosylhomocysteine deaminase activity
EP13_RS07010	COG2755	lipolytic protein G-D-S-L family
EP13_RS07015	COG4181	ATPase activity
EP13_RS07020	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EP13_RS07025	COG1090	epimerase
EP13_RS07030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EP13_RS07035	COG0628	permease
EP13_RS07060	COG2350	Protein conserved in bacteria
EP13_RS07065	COG0159	tryptophan synthase activity
EP13_RS07075	COG0134	indole-3-glycerol-phosphate synthase activity
EP13_RS07075	COG0135	phosphoribosylanthranilate isomerase activity
EP13_RS07080	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EP13_RS07090	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EP13_RS07095	COG0613	PHP domain protein
EP13_RS07100	COG0009	L-threonylcarbamoyladenylate synthase
EP13_RS07105	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EP13_RS07110	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EP13_RS07120	COG0656	L-ascorbic acid biosynthetic process
EP13_RS07125	COG0110	maltose O-acetyltransferase activity
EP13_RS07140	COG2733	membrane
EP13_RS07145	COG0500	methyltransferase
EP13_RS07150	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP13_RS07155	COG0497	DNA recombination
EP13_RS07165	COG0783	Belongs to the Dps family
EP13_RS07170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EP13_RS07175	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_RS07185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EP13_RS07190	COG2610	gluconate transmembrane transporter activity
EP13_RS07195	COG4771	TonB-dependent receptor
EP13_RS07210	COG2202	Pas domain
EP13_RS07210	COG2205	protein histidine kinase activity
EP13_RS07215	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EP13_RS07225	COG0484	heat shock protein binding
EP13_RS07230	COG3909	cytochrome
EP13_RS07235	COG3300	MHYT domain
EP13_RS07235	COG5001	Diguanylate cyclase
EP13_RS07245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EP13_RS07255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EP13_RS07260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EP13_RS07275	COG0071	Belongs to the small heat shock protein (HSP20) family
EP13_RS07285	COG0280	phosphate acetyltransferase
EP13_RS07285	COG0857	belongs to the CobB CobQ family
EP13_RS07290	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EP13_RS07295	COG4535	Mg2 and Co2 transporter CorC
EP13_RS07300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EP13_RS07320	COG1702	phosphate starvation-inducible protein PhoH
EP13_RS07330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP13_RS07350	COG1607	acyl-coa hydrolase
EP13_RS07355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EP13_RS07360	COG1115	amino acid carrier protein
EP13_RS07420	COG0012	GTP binding
EP13_RS07445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EP13_RS07455	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EP13_RS07460	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EP13_RS07465	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EP13_RS07475	COG2890	protein-(glutamine-N5) methyltransferase activity
EP13_RS07480	COG3437	response regulator, receiver
EP13_RS07480	COG0784	Response regulator, receiver
EP13_RS07490	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EP13_RS07500	COG0583	DNA-binding transcription factor activity
EP13_RS07510	COG2363	Small membrane protein
EP13_RS07520	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EP13_RS07530	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EP13_RS07535	COG0515	serine threonine protein kinase
EP13_RS07535	COG2815	serine threonine protein kinase
EP13_RS07540	COG2116	formate transmembrane transporter activity
EP13_RS07545	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EP13_RS07550	COG0033	Phosphoglucomutase
EP13_RS07555	COG0058	SHG alpha-glucan phosphorylase activity
EP13_RS07565	COG2988	succinylglutamate desuccinylase activity
EP13_RS07595	COG1393	Belongs to the ArsC family
EP13_RS07620	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EP13_RS07645	COG3447	MASE1 domain protein
EP13_RS07645	COG5001	Diguanylate cyclase
EP13_RS07645	COG5002	protein histidine kinase activity
EP13_RS07655	COG0402	S-adenosylhomocysteine deaminase activity
EP13_RS07660	COG2351	hydroxyisourate hydrolase activity
EP13_RS07675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EP13_RS07685	COG1309	transcriptional regulator
EP13_RS07700	COG2252	PERMEase
EP13_RS07705	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EP13_RS07715	COG5001	Diguanylate cyclase
EP13_RS07715	COG3300	MHYT domain
EP13_RS07725	COG0784	Response regulator, receiver
EP13_RS07725	COG2205	protein histidine kinase activity
EP13_RS07750	COG2233	PERMEase
EP13_RS07770	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EP13_RS07775	COG0730	response to heat
EP13_RS07815	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_RS07820	COG3001	Fructosamine kinase
EP13_RS07830	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EP13_RS07845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EP13_RS07855	COG1596	polysaccharide export
EP13_RS07860	COG0489	protein tyrosine kinase activity
EP13_RS07865	COG4464	protein tyrosine phosphatase activity
EP13_RS07875	COG0438	transferase activity, transferring glycosyl groups
EP13_RS07890	COG5001	Diguanylate cyclase
EP13_RS07890	COG3300	MHYT domain
EP13_RS07915	COG2755	lipolytic protein G-D-S-L family
EP13_RS07915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EP13_RS07940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EP13_RS07945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EP13_RS07950	COG0463	Glycosyl transferase, family 2
EP13_RS07950	COG1216	Glycosyl transferase, family 2
EP13_RS07970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP13_RS07970	COG0072	phenylalanine-tRNA ligase activity
EP13_RS07995	COG1472	Belongs to the glycosyl hydrolase 3 family
EP13_RS08000	COG2096	Adenosyltransferase
EP13_RS08010	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EP13_RS08020	COG4591	ABC-type transport system involved in lipoprotein release permease component
EP13_RS08025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EP13_RS08035	COG0708	Exodeoxyribonuclease III
EP13_RS08070	COG2814	Major facilitator Superfamily
EP13_RS08100	COG4770	biotin carboxylase activity
EP13_RS08110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EP13_RS08115	COG1960	acyl-CoA dehydrogenase activity
EP13_RS08120	COG0789	Transcriptional regulator
EP13_RS08125	COG0183	Belongs to the thiolase family
EP13_RS08140	COG2925	Exonuclease
EP13_RS08180	COG1643	Atp-dependent helicase
EP13_RS08200	COG3321	synthase
EP13_RS08200	COG0604	alcohol dehydrogenase
EP13_RS08205	COG0328	RNA-DNA hybrid ribonuclease activity
EP13_RS08240	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EP13_RS08245	COG1136	(ABC) transporter
EP13_RS08250	COG4591	ABC-type transport system involved in lipoprotein release permease component
EP13_RS08265	COG3724	N-succinylarginine dihydrolase activity
EP13_RS08270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EP13_RS08275	COG3122	Protein conserved in bacteria
EP13_RS08280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EP13_RS08285	COG2153	protein acetylation
EP13_RS08300	COG1530	ribonuclease E activity
EP13_RS08305	COG0564	pseudouridine synthase activity
EP13_RS08310	COG0546	phosphoglycolate phosphatase activity
EP13_RS08320	COG1399	metal-binding, possibly nucleic acid-binding protein
EP13_RS08330	COG0416	fatty acid biosynthetic process
EP13_RS08335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EP13_RS08350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EP13_RS08355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EP13_RS08365	COG0596	Alpha beta hydrolase
EP13_RS08370	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP13_RS08370	COG1024	Enoyl-CoA hydratase
EP13_RS08375	COG0183	Belongs to the thiolase family
EP13_RS08380	COG1960	acyl-CoA dehydrogenase activity
EP13_RS08390	COG2390	Transcriptional regulator
EP13_RS08395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP13_RS08425	COG0668	transmembrane transport
EP13_RS08430	COG4771	TonB-dependent receptor
EP13_RS08450	COG2205	protein histidine kinase activity
EP13_RS08450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP13_RS08455	COG3437	response regulator, receiver
EP13_RS08465	COG0195	Participates in both transcription termination and antitermination
EP13_RS08480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EP13_RS08490	COG3706	GGDEF domain
EP13_RS08495	COG0596	Alpha beta hydrolase
EP13_RS08505	COG3153	acetyltransferase
EP13_RS08505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP13_RS08590	COG4771	TonB-dependent receptor
EP13_RS08595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP13_RS08605	COG4134	Bacterial extracellular solute-binding protein
EP13_RS08610	COG4135	transport system, permease component
EP13_RS08615	COG4136	ATPase activity
EP13_RS08620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EP13_RS08630	COG3932	Exopolysaccharide synthesis, ExoD
EP13_RS08635	COG0604	alcohol dehydrogenase
EP13_RS08685	COG1131	(ABC) transporter
EP13_RS08700	COG1902	pentaerythritol trinitrate reductase activity
EP13_RS08710	COG2867	negative regulation of translational initiation
EP13_RS08715	COG2914	Belongs to the UPF0125 (RnfH) family
EP13_RS08725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EP13_RS08730	COG4771	TonB-dependent receptor
EP13_RS08735	COG0457	Tetratricopeptide repeat
EP13_RS08745	COG0574	Belongs to the PEP-utilizing enzyme family
EP13_RS08745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EP13_RS08765	COG0247	lactate metabolic process
EP13_RS08765	COG0277	FAD linked oxidase domain protein
EP13_RS08775	COG2850	peptidyl-arginine hydroxylation
EP13_RS08785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EP13_RS08790	COG2915	High frequency lysogenization protein hflD homolog
EP13_RS08795	COG0482	sulfurtransferase activity
EP13_RS08800	COG1187	pseudouridine synthase activity
EP13_RS08810	COG1278	Cold shock
EP13_RS08815	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EP13_RS08820	COG0542	response to heat
EP13_RS08825	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EP13_RS08830	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EP13_RS08835	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EP13_RS08840	COG0492	ferredoxin-NADP+ reductase activity
EP13_RS08845	COG3092	negative regulation of chromosome organization
EP13_RS08850	COG3091	SprT-like family
EP13_RS08855	COG0616	signal peptide processing
EP13_RS08865	COG0778	Nitroreductase
EP13_RS08875	COG0252	asparaginase activity
EP13_RS08880	COG3706	GGDEF domain
EP13_RS08885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EP13_RS08890	COG0321	lipoyl(octanoyl) transferase activity
EP13_RS08895	COG2921	Belongs to the UPF0250 family
EP13_RS08900	COG1686	Belongs to the peptidase S11 family
EP13_RS08905	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EP13_RS08910	COG0772	Belongs to the SEDS family
EP13_RS08915	COG0768	penicillin binding
EP13_RS08920	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EP13_RS08925	COG0799	negative regulation of ribosome biogenesis
EP13_RS08930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EP13_RS08935	COG1466	dna polymerase III delta subunit
EP13_RS08940	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EP13_RS08945	COG0495	leucyl-tRNA aminoacylation
EP13_RS08950	COG1067	ATP-dependent peptidase activity
EP13_RS08960	COG1534	Rna-binding protein
EP13_RS08965	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EP13_RS08970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP13_RS08975	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EP13_RS08980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EP13_RS08985	COG0149	triose-phosphate isomerase activity
EP13_RS08990	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EP13_RS09030	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_RS09045	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP13_RS09050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EP13_RS09055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EP13_RS09070	COG1185	polyribonucleotide nucleotidyltransferase activity
EP13_RS09090	COG0295	cytidine deaminase activity
EP13_RS09105	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EP13_RS09110	COG1196	nuclear chromosome segregation
EP13_RS09120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EP13_RS09130	COG2333	competence protein COMEC
EP13_RS09130	COG0658	competence protein
EP13_RS09135	COG1132	(ABC) transporter
EP13_RS09140	COG1663	tetraacyldisaccharide 4'-kinase activity
EP13_RS09285	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EP13_RS09290	COG0435	Glutathione S-transferase
EP13_RS09315	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EP13_RS09320	COG1053	succinate dehydrogenase
EP13_RS09325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EP13_RS09330	COG0567	Dehydrogenase, E1 component
EP13_RS09335	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP13_RS09375	COG4667	esterase of the alpha-beta hydrolase superfamily
EP13_RS09390	COG0366	Alpha amylase catalytic
EP13_RS09415	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_RS09420	COG2267	carboxylic ester hydrolase activity
EP13_RS09430	COG0616	signal peptide processing
EP13_RS09440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EP13_RS09445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EP13_RS09450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EP13_RS09455	COG0386	Belongs to the glutathione peroxidase family
EP13_RS09460	COG2084	Dehydrogenase
EP13_RS09480	COG1960	acyl-CoA dehydrogenase activity
EP13_RS09485	COG1024	Enoyl-CoA hydratase
EP13_RS09495	COG2226	methyltransferase
EP13_RS09500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EP13_RS09505	COG3083	sulfuric ester hydrolase activity
EP13_RS09510	COG3082	Protein of unknown function (DUF1414)
EP13_RS09515	COG3081	Nucleoid-associated protein
EP13_RS09545	COG3275	phosphorelay sensor kinase activity
EP13_RS09550	COG3279	Response regulator of the LytR AlgR family
EP13_RS09555	COG0205	6-phosphofructokinase activity
EP13_RS09580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP13_RS09580	COG2205	protein histidine kinase activity
EP13_RS09590	COG1054	Belongs to the UPF0176 family
EP13_RS09610	COG0513	Belongs to the DEAD box helicase family
EP13_RS09620	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EP13_RS09625	COG0583	DNA-binding transcription factor activity
EP13_RS09655	COG1760	l-serine dehydratase
EP13_RS09680	COG2199	diguanylate cyclase activity
EP13_RS09690	COG1404	Belongs to the peptidase S8 family
EP13_RS09700	COG0022	dehydrogenase e1 component
EP13_RS09710	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EP13_RS09715	COG0515	serine threonine protein kinase
EP13_RS09720	COG1946	Acyl-CoA thioesterase
EP13_RS09730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EP13_RS09740	COG1956	GAF domain-containing protein
EP13_RS09755	COG0793	Belongs to the peptidase S41A family
EP13_RS09760	COG0733	neurotransmitter:sodium symporter activity
EP13_RS09765	COG1757	Na H antiporter
EP13_RS09770	COG0308	aminopeptidase N
EP13_RS09805	COG0167	dihydroorotate dehydrogenase activity
EP13_RS09820	COG0488	(ABC) transporter
EP13_RS09830	COG3130	regulation of translation
EP13_RS09835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EP13_RS09845	COG0415	Belongs to the DNA photolyase family
EP13_RS09850	COG0415	Belongs to the DNA photolyase family
EP13_RS09855	COG0415	Belongs to the DNA photolyase family
EP13_RS09860	COG3046	protein related to deoxyribodipyrimidine photolyase
EP13_RS09880	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EP13_RS09885	COG0589	response to stress
EP13_RS09895	COG0069	glutamate synthase activity
EP13_RS09910	COG2193	ferroxidase activity
EP13_RS09920	COG3278	Belongs to the heme-copper respiratory oxidase family
EP13_RS09935	COG2010	Cytochrome c
EP13_RS09960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP13_RS09965	COG0589	response to stress
EP13_RS09970	COG0037	tRNA processing
EP13_RS09975	COG1752	Esterase of the alpha-beta hydrolase superfamily
EP13_RS09995	COG1280	lysine exporter protein (LysE YggA)
EP13_RS10005	COG2897	thiosulfate sulfurtransferase activity
EP13_RS10010	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EP13_RS10015	COG3148	PFAM DTW domain containing protein
EP13_RS10085	COG0582	viral genome integration into host DNA
EP13_RS10110	COG0322	excinuclease ABC activity
EP13_RS10115	COG2197	response regulator
EP13_RS10120	COG1741	Belongs to the pirin family
EP13_RS10125	COG0436	Aminotransferase
EP13_RS10130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EP13_RS10140	COG3384	dioxygenase
EP13_RS10145	COG2259	Doxx family
EP13_RS10150	COG0583	DNA-binding transcription factor activity
EP13_RS10165	COG0670	Belongs to the BI1 family
EP13_RS10170	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EP13_RS10185	COG2920	part of a sulfur-relay system
EP13_RS10190	COG0561	phosphatase activity
EP13_RS10220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EP13_RS10225	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EP13_RS10230	COG1674	ftsk spoiiie
EP13_RS10230	COG0531	amino acid
EP13_RS10240	COG0686	Belongs to the AlaDH PNT family
EP13_RS10245	COG0284	orotidine-5'-phosphate decarboxylase activity
EP13_RS10250	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EP13_RS10265	COG0776	regulation of translation
EP13_RS10270	COG0539	negative regulation of cytoplasmic translation
EP13_RS10275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EP13_RS10280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EP13_RS10285	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EP13_RS10300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EP13_RS10305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EP13_RS10310	COG0633	Ferredoxin
EP13_RS10350	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EP13_RS10355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EP13_RS10365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EP13_RS10375	COG4783	chaperone-mediated protein folding
EP13_RS10380	COG4232	protein-disulfide reductase activity
EP13_RS10385	COG1393	Belongs to the ArsC family
EP13_RS10405	COG0789	Transcriptional regulator
EP13_RS10435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EP13_RS10450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EP13_RS10460	COG1960	acyl-CoA dehydrogenase activity
EP13_RS10485	COG3769	mannosylglycerate metabolic process
EP13_RS10490	COG1215	transferase activity, transferring glycosyl groups
EP13_RS10505	COG0303	'Molybdopterin
EP13_RS10510	COG0534	Mate efflux family protein
EP13_RS10525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP13_RS10530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EP13_RS10540	COG0405	Gamma-glutamyltransferase
EP13_RS10545	COG1024	Enoyl-CoA hydratase
EP13_RS10585	COG1448	Aminotransferase
EP13_RS10595	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EP13_RS10605	COG1671	Belongs to the UPF0178 family
EP13_RS10610	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_RS10615	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_RS10620	COG1960	acyl-CoA dehydrogenase activity
EP13_RS10625	COG4977	sequence-specific DNA binding
EP13_RS10675	COG0596	Alpha beta hydrolase
EP13_RS10685	COG0716	FMN binding
EP13_RS10695	COG0735	belongs to the Fur family
EP13_RS10705	COG1984	allophanate hydrolase subunit 2
EP13_RS10715	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EP13_RS10720	COG2996	Protein conserved in bacteria
EP13_RS10740	COG0436	Aminotransferase
EP13_RS10745	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EP13_RS10750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EP13_RS10765	COG4771	TonB-dependent receptor
EP13_RS10770	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EP13_RS10775	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EP13_RS10780	COG1238	metal cluster binding
EP13_RS10790	COG3012	SEC-C Motif Domain Protein
EP13_RS10805	COG0456	acetyltransferase
EP13_RS10810	COG3706	GGDEF domain
EP13_RS10815	COG0702	epimerase
EP13_RS10825	COG0084	hydrolase, TatD family'
EP13_RS10840	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EP13_RS10845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EP13_RS10875	COG4771	TonB-dependent receptor
EP13_RS10895	COG1618	nucleotide phosphatase activity, acting on free nucleotides
EP13_RS10895	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EP13_RS10915	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EP13_RS10925	COG0521	Mo-molybdopterin cofactor biosynthetic process
EP13_RS10930	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EP13_RS10950	COG0436	Aminotransferase
EP13_RS10955	COG3268	Saccharopine dehydrogenase
EP13_RS10960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP13_RS10985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EP13_RS10990	COG1074	ATP-dependent DNA helicase activity
EP13_RS10995	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EP13_RS11005	COG1022	Amp-dependent synthetase and ligase
EP13_RS11020	COG3132	Protein of unknown function, DUF480
EP13_RS11035	COG0583	DNA-binding transcription factor activity
EP13_RS11040	COG3085	chromosome segregation
EP13_RS11050	COG0640	Transcriptional regulator
EP13_RS11070	COG2204	response regulator
EP13_RS11080	COG4251	negative regulation of phosphorylation
EP13_RS11085	COG0784	Response regulator, receiver
EP13_RS11090	COG0784	Response regulator, receiver
EP13_RS11090	COG2205	protein histidine kinase activity
EP13_RS11135	COG3139	Protein of unknown function (DUF1315)
EP13_RS11145	COG1115	amino acid carrier protein
EP13_RS11150	COG2866	Carboxypeptidase
EP13_RS11170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EP13_RS11180	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EP13_RS11185	COG1640	4-alpha-glucanotransferase
EP13_RS11195	COG0676	glucose-6-phosphate 1-epimerase activity
EP13_RS11200	COG0800	Aldolase
EP13_RS11205	COG0837	glucose binding
EP13_RS11210	COG0129	dihydroxy-acid dehydratase activity
EP13_RS11220	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EP13_RS11225	COG1737	Transcriptional regulator
EP13_RS11230	COG0469	pyruvate kinase activity
EP13_RS11235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EP13_RS11275	COG2205	protein histidine kinase activity
EP13_RS11280	COG0745	RESPONSE REGULATOR receiver
EP13_RS11305	COG3665	Urea carboxylase-associated protein
EP13_RS11315	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_RS11320	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EP13_RS11345	COG2721	sulfolactate sulfo-lyase activity
EP13_RS11350	COG1904	glucuronate isomerase
EP13_RS11355	COG0246	Mannitol dehydrogenase
EP13_RS11360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP13_RS11365	COG2755	lipolytic protein G-D-S-L family
EP13_RS11375	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EP13_RS11385	COG4677	pectinesterase activity
EP13_RS11390	COG0784	Response regulator, receiver
EP13_RS11390	COG2205	protein histidine kinase activity
EP13_RS11390	COG5002	protein histidine kinase activity
EP13_RS11400	COG0308	aminopeptidase N
EP13_RS11405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP13_RS11415	COG1119	ATPase activity
EP13_RS11430	COG1609	Transcriptional regulator
EP13_RS11435	COG4948	Mandelate Racemase Muconate Lactonizing
EP13_RS11455	COG5001	Diguanylate cyclase
EP13_RS11455	COG3300	MHYT domain
EP13_RS11475	COG0745	RESPONSE REGULATOR receiver
EP13_RS11480	COG2205	protein histidine kinase activity
EP13_RS11490	COG3437	response regulator, receiver
EP13_RS11490	COG0784	Response regulator, receiver
EP13_RS11495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP13_RS11495	COG4191	Histidine kinase
EP13_RS11505	COG0612	Peptidase, M16
EP13_RS11535	COG0330	HflC and HflK could
EP13_RS11555	COG0471	metal ion transport
EP13_RS11565	COG0489	protein tyrosine kinase activity
EP13_RS11570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP13_RS11570	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP13_RS11575	COG2226	methyltransferase
EP13_RS11580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP13_RS11585	COG0741	lytic transglycosylase activity
EP13_RS11585	COG1388	LysM domain
EP13_RS11595	COG0215	cysteine-tRNA ligase activity
EP13_RS11600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EP13_RS11610	COG1785	Belongs to the alkaline phosphatase family
EP13_RS11615	COG1785	Belongs to the alkaline phosphatase family
EP13_RS11630	COG2268	Band 7 protein
EP13_RS11640	COG0583	DNA-binding transcription factor activity
EP13_RS11645	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EP13_RS11660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EP13_RS11665	COG1286	toxin biosynthetic process
EP13_RS11670	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EP13_RS11675	COG0285	dihydrofolate synthase activity
EP13_RS11700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP13_RS11710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EP13_RS11715	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EP13_RS11715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EP13_RS11740	COG0668	transmembrane transport
EP13_RS11745	COG2205	protein histidine kinase activity
EP13_RS11745	COG0784	Response regulator, receiver
EP13_RS11745	COG5002	protein histidine kinase activity
EP13_RS11760	COG3101	peptidyl-lysine hydroxylation
EP13_RS11780	COG1902	pentaerythritol trinitrate reductase activity
EP13_RS11780	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP13_RS11805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EP13_RS11815	COG4399	Belongs to the UPF0754 family
EP13_RS11845	COG2186	Transcriptional regulator
EP13_RS11855	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EP13_RS11860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EP13_RS11865	COG2983	Belongs to the UPF0260 family
EP13_RS11870	COG0179	Fumarylacetoacetate (FAA) hydrolase
EP13_RS11885	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EP13_RS11890	COG0318	PFAM AMP-dependent synthetase and ligase
EP13_RS11895	COG2267	carboxylic ester hydrolase activity
EP13_RS11910	COG1214	PFAM Peptidase M22, glycoprotease
EP13_RS11915	COG1199	ATP-dependent helicase activity
EP13_RS11945	COG4771	TonB-dependent receptor
EP13_RS11955	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EP13_RS11960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EP13_RS11965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP13_RS11970	COG0131	Imidazoleglycerol-phosphate dehydratase
EP13_RS11970	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EP13_RS11975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EP13_RS12000	COG0583	DNA-binding transcription factor activity
EP13_RS12005	COG2116	formate transmembrane transporter activity
EP13_RS12015	COG4206	TonB-dependent receptor
EP13_RS12035	COG0326	Molecular chaperone. Has ATPase activity
EP13_RS12040	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EP13_RS12060	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EP13_RS12065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EP13_RS12075	COG3220	belongs to the UPF0276 family
EP13_RS12085	COG4249	Peptidase C14 caspase catalytic subunit p20
EP13_RS12085	COG2319	Wd-40 repeat
EP13_RS12100	COG2203	Gaf domain
EP13_RS12100	COG5001	Diguanylate cyclase
EP13_RS12100	COG4251	negative regulation of phosphorylation
EP13_RS12100	COG3706	GGDEF domain
EP13_RS12130	COG1183	phosphatidylcholine synthase activity
EP13_RS12150	COG0542	response to heat
EP13_RS12160	COG0564	pseudouridine synthase activity
EP13_RS12175	COG1595	DNA-templated transcription, initiation
EP13_RS12190	COG4221	oxidoreductase activity
EP13_RS12205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EP13_RS12215	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EP13_RS12225	COG0142	geranyltranstransferase activity
EP13_RS12235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EP13_RS12250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EP13_RS12265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EP13_RS12265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EP13_RS12280	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP13_RS12285	COG0488	(ABC) transporter
EP13_RS12295	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EP13_RS12305	COG0560	Phosphoserine phosphatase
EP13_RS12315	COG0084	hydrolase, TatD family'
EP13_RS12360	COG1595	DNA-templated transcription, initiation
EP13_RS12365	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EP13_RS12380	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EP13_RS12460	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EP13_RS12465	COG1047	Peptidyl-prolyl cis-trans
EP13_RS12475	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EP13_RS12480	COG0196	riboflavin kinase activity
EP13_RS12485	COG0728	peptidoglycan biosynthetic process
EP13_RS12490	COG0268	Binds directly to 16S ribosomal RNA
EP13_RS12520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP13_RS12525	COG0776	regulation of translation
EP13_RS12530	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EP13_RS12535	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EP13_RS12540	COG0740	serine-type endopeptidase activity
EP13_RS12545	COG0544	peptidyl-prolyl cis-trans isomerase activity
EP13_RS12585	COG1720	tRNA m6t6A37 methyltransferase activity
EP13_RS12605	COG0123	including yeast histone deacetylase and acetoin utilization protein
EP13_RS12620	COG0517	IMP dehydrogenase activity
EP13_RS12620	COG0516	GMP reductase activity
EP13_RS12625	COG1570	exodeoxyribonuclease VII activity
EP13_RS12640	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP13_RS12645	COG2976	Protein conserved in bacteria
EP13_RS12660	COG1426	Protein conserved in bacteria
EP13_RS12670	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EP13_RS12680	COG2166	iron-sulfur cluster assembly
EP13_RS12695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EP13_RS12700	COG0719	Fe-S assembly protein
EP13_RS12705	COG0396	ATPase activity
EP13_RS12710	COG0719	Fe-S assembly protein
EP13_RS12715	COG1104	cysteine desulfurase activity
EP13_RS12725	COG1045	serine acetyltransferase
EP13_RS12730	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EP13_RS12735	COG0483	inositol monophosphate 1-phosphatase activity
EP13_RS12750	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP13_RS12755	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP13_RS12760	COG1862	Preprotein translocase
EP13_RS12765	COG0343	queuine tRNA-ribosyltransferase activity
EP13_RS12785	COG1842	Phage shock protein A
EP13_RS12790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EP13_RS12810	COG0754	glutathionylspermidine amidase activity
EP13_RS12825	COG2066	Belongs to the glutaminase family
EP13_RS12830	COG1785	Belongs to the alkaline phosphatase family
EP13_RS12835	COG0745	RESPONSE REGULATOR receiver
EP13_RS12900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EP13_RS12935	COG0367	asparagine synthase
EP13_RS12965	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EP13_RS12965	COG2755	lipolytic protein G-D-S-L family
EP13_RS13030	COG0489	protein tyrosine kinase activity
EP13_RS13040	COG3267	Type II secretory pathway component ExeA
EP13_RS13040	COG3409	Peptidoglycan-binding domain 1 protein
EP13_RS13050	COG2827	Endonuclease containing a URI domain
EP13_RS13070	COG1560	Kdo2-lipid A biosynthetic process
EP13_RS13080	COG1960	acyl-CoA dehydrogenase activity
EP13_RS13100	COG1435	thymidine kinase activity
EP13_RS13105	COG1609	Transcriptional regulator
EP13_RS13110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EP13_RS13145	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EP13_RS13150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP13_RS13175	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP13_RS13175	COG1024	Enoyl-CoA hydratase
EP13_RS13190	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EP13_RS13210	COG1960	acyl-CoA dehydrogenase activity
EP13_RS13235	COG2080	2 iron, 2 sulfur cluster binding
EP13_RS13240	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EP13_RS13245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EP13_RS13265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EP13_RS13295	COG0583	DNA-binding transcription factor activity
EP13_RS13300	COG0523	cobalamin synthesis protein
EP13_RS13325	COG0693	protein deglycase activity
EP13_RS13345	COG2233	PERMEase
EP13_RS13350	COG0402	S-adenosylhomocysteine deaminase activity
EP13_RS13360	COG1595	DNA-templated transcription, initiation
EP13_RS13400	COG1295	ribonuclease BN
EP13_RS13405	COG2197	response regulator
EP13_RS13525	COG0514	ATP-dependent DNA helicase (RecQ)
EP13_RS13530	COG2267	carboxylic ester hydrolase activity
EP13_RS13555	COG1595	DNA-templated transcription, initiation
EP13_RS13560	COG0596	Alpha beta hydrolase
EP13_RS13565	COG1764	response to oxidative stress
EP13_RS13570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EP13_RS13585	COG4555	ABC transporter
EP13_RS13600	COG0513	Belongs to the DEAD box helicase family
EP13_RS13615	COG0235	Class ii aldolase
EP13_RS13630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP13_RS13635	COG0577	efflux transmembrane transporter activity
EP13_RS13635	COG1136	(ABC) transporter
EP13_RS13640	COG1136	(ABC) transporter
EP13_RS13640	COG0577	efflux transmembrane transporter activity
EP13_RS13650	COG3852	Histidine kinase
EP13_RS13695	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EP13_RS13695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EP13_RS13720	COG1609	Transcriptional regulator
EP13_RS13730	COG2971	BadF BadG BcrA BcrD
EP13_RS13735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EP13_RS13740	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EP13_RS13750	COG0583	DNA-binding transcription factor activity
EP13_RS13755	COG0006	proline dipeptidase activity
EP13_RS13765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP13_RS13770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP13_RS13775	COG0006	proline dipeptidase activity
EP13_RS13785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP13_RS13795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EP13_RS13800	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EP13_RS13805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP13_RS13825	COG3313	Fe-S protein
EP13_RS13845	COG4948	Mandelate Racemase Muconate Lactonizing
EP13_RS13850	COG2186	Transcriptional regulator
EP13_RS13860	COG0546	phosphoglycolate phosphatase activity
EP13_RS13870	COG3962	Belongs to the TPP enzyme family
EP13_RS13880	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EP13_RS13885	COG3718	enzyme involved in inositol metabolism
EP13_RS13895	COG1904	glucuronate isomerase
EP13_RS13900	COG0246	Mannitol dehydrogenase
EP13_RS13910	COG0673	inositol 2-dehydrogenase activity
EP13_RS13920	COG1175	transmembrane transport
EP13_RS13925	COG0395	ABC-type sugar transport system, permease component
EP13_RS13935	COG4771	TonB-dependent receptor
EP13_RS13960	COG5434	Belongs to the glycosyl hydrolase 28 family
EP13_RS13975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP13_RS13980	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP13_RS13985	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EP13_RS14005	COG3577	Aspartyl protease
EP13_RS14015	COG4969	Belongs to the N-Me-Phe pilin family
EP13_RS14020	COG1459	type II secretion system
EP13_RS14025	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EP13_RS14030	COG0237	dephospho-CoA kinase activity
EP13_RS14035	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EP13_RS14040	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EP13_RS14060	COG1621	beta-fructofuranosidase activity
EP13_RS14065	COG2814	Major facilitator Superfamily
EP13_RS14070	COG0702	epimerase
EP13_RS14075	COG1629	transport
EP13_RS14080	COG3608	succinylglutamate desuccinylase aspartoacylase
EP13_RS14095	COG0739	heme binding
EP13_RS14100	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EP13_RS14105	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EP13_RS14110	COG0849	cell division
EP13_RS14115	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EP13_RS14120	COG1181	Belongs to the D-alanine--D-alanine ligase family
EP13_RS14125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EP13_RS14135	COG0772	Belongs to the SEDS family
EP13_RS14140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EP13_RS14150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EP13_RS14155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EP13_RS14160	COG0768	penicillin binding
EP13_RS14165	COG3116	cell division
EP13_RS14175	COG2001	Belongs to the MraZ family
EP13_RS14190	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP13_RS14215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EP13_RS14215	COG0678	peroxiredoxin activity
EP13_RS14230	COG2356	endonuclease I
EP13_RS14235	COG2204	response regulator
EP13_RS14250	COG2084	Dehydrogenase
EP13_RS14255	COG2271	Major facilitator Superfamily
EP13_RS14285	COG0668	transmembrane transport
EP13_RS14295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EP13_RS14305	COG1678	Uncharacterized ACR, COG1678
EP13_RS14310	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EP13_RS14330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EP13_RS14335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EP13_RS14340	COG0762	integral membrane protein
EP13_RS14350	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP13_RS14350	COG1902	pentaerythritol trinitrate reductase activity
EP13_RS14380	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EP13_RS14410	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EP13_RS14415	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EP13_RS14420	COG0083	homoserine kinase activity
EP13_RS14430	COG0583	DNA-binding transcription factor activity
EP13_RS14445	COG0640	Transcriptional regulator
EP13_RS14455	COG0431	NADPH-dependent FMN reductase
EP13_RS14460	COG0798	PFAM Bile acid sodium symporter
EP13_RS14465	COG2201	protein-glutamate methylesterase activity
EP13_RS14470	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EP13_RS14480	COG2205	protein histidine kinase activity
EP13_RS14495	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EP13_RS14505	COG1748	Saccharopine dehydrogenase
EP13_RS14525	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EP13_RS14535	COG0792	nuclease activity
EP13_RS14545	COG2823	Periplasmic or secreted lipoprotein
EP13_RS14570	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EP13_RS14575	COG0372	Belongs to the citrate synthase family
EP13_RS14580	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EP13_RS14585	COG2828	Protein conserved in bacteria
EP13_RS14590	COG2199	diguanylate cyclase activity
EP13_RS14590	COG2203	Gaf domain
EP13_RS14610	COG5002	protein histidine kinase activity
EP13_RS14610	COG2198	Histidine kinase
EP13_RS14610	COG0784	Response regulator, receiver
EP13_RS14615	COG3023	N-Acetylmuramoyl-L-alanine amidase
EP13_RS14620	COG0069	glutamate synthase activity
EP13_RS14620	COG0067	glutamate synthase
EP13_RS14620	COG0070	glutamate synthase
EP13_RS14625	COG0493	'glutamate synthase
EP13_RS14640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EP13_RS14650	COG2755	lipolytic protein G-D-S-L family
EP13_RS14670	COG3401	FG-GAP repeat protein
EP13_RS14675	COG1304	FMN binding
EP13_RS14680	COG4952	isomerase
EP13_RS14685	COG3347	Dehydrogenase
EP13_RS14685	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_RS14700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP13_RS14705	COG1414	Transcriptional regulator
EP13_RS14710	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_RS14725	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EP13_RS14740	COG3254	rhamnose metabolic process
EP13_RS14755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP13_RS14765	COG5507	3-demethylubiquinone-9 3-methyltransferase
EP13_RS14770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EP13_RS14775	COG0741	lytic transglycosylase activity
EP13_RS14775	COG1196	nuclear chromosome segregation
EP13_RS14775	COG0739	heme binding
EP13_RS14780	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EP13_RS14785	COG3437	response regulator, receiver
EP13_RS14795	COG1902	pentaerythritol trinitrate reductase activity
EP13_RS14810	COG0625	glutathione transferase activity
EP13_RS14840	COG2894	cell division
EP13_RS14845	COG0850	regulation of cytokinetic process
EP13_RS14875	COG1981	membrane
EP13_RS14890	COG1914	H( )-stimulated, divalent metal cation uptake system
EP13_RS14895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP13_RS14905	COG1217	gtp-binding protein TYPA
EP13_RS14910	COG0174	glutamine synthetase
EP13_RS14920	COG3852	Histidine kinase
EP13_RS14925	COG2204	response regulator
EP13_RS14930	COG3437	response regulator, receiver
EP13_RS14950	COG3706	GGDEF domain
EP13_RS14960	COG2205	protein histidine kinase activity
EP13_RS14960	COG5002	protein histidine kinase activity
EP13_RS14960	COG0784	Response regulator, receiver
EP13_RS14965	COG0525	valine-tRNA ligase activity
EP13_RS14970	COG2927	DNA polymerase III (CHI subunit)
EP13_RS14975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EP13_RS14980	COG0795	lipopolysaccharide-transporting ATPase activity
EP13_RS14985	COG0795	lipopolysaccharide-transporting ATPase activity
EP13_RS14995	COG1414	Transcriptional regulator
EP13_RS15000	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP13_RS15005	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_RS15015	COG3246	L-lysine catabolic process to acetate
EP13_RS15020	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP13_RS15070	COG1131	(ABC) transporter
EP13_RS15080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EP13_RS15100	COG0535	radical SAM domain protein
EP13_RS15130	COG0784	Response regulator, receiver
EP13_RS15130	COG2205	protein histidine kinase activity
EP13_RS15140	COG0348	domain, Protein
EP13_RS15140	COG3901	Regulator of nitric oxide reductase transcription
EP13_RS15150	COG2197	response regulator
EP13_RS15155	COG4585	Histidine kinase
EP13_RS15190	COG0793	Belongs to the peptidase S41A family
EP13_RS15190	COG4946	Tricorn protease homolog
EP13_RS15245	COG3209	COG3209 Rhs family protein
EP13_RS15250	COG4206	TonB-dependent receptor
EP13_RS15255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EP13_RS15260	COG4139	cobalamin transport
EP13_RS15265	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EP13_RS15270	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EP13_RS15280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EP13_RS15290	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_RS15305	COG1609	Transcriptional regulator
EP13_RS15325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP13_RS15335	COG0395	ABC-type sugar transport system, permease component
EP13_RS15360	COG2267	carboxylic ester hydrolase activity
EP13_RS15375	COG1116	anion transmembrane transporter activity
EP13_RS15400	COG0513	Belongs to the DEAD box helicase family
EP13_RS15405	COG0800	Aldolase
EP13_RS15410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP13_RS15425	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EP13_RS15425	COG3264	Mechanosensitive ion channel
EP13_RS15430	COG2207	Transcriptional regulator
EP13_RS15450	COG0475	glutathione-regulated potassium exporter activity
EP13_RS15450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EP13_RS15465	COG3568	Endonuclease Exonuclease Phosphatase
EP13_RS15480	COG0730	response to heat
EP13_RS15485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP13_RS15500	COG4191	Histidine kinase
EP13_RS15505	COG0417	DNA replication proofreading
EP13_RS15565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP13_RS15575	COG1573	uracil-dna glycosylase
EP13_RS15600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EP13_RS15625	COG1842	Phage shock protein A
EP13_RS15640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP13_RS15645	COG4529	Protein conserved in bacteria
EP13_RS15660	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EP13_RS15675	COG0204	Acyl-transferase
EP13_RS15680	COG0204	Acyl-transferase
EP13_RS15685	COG0668	transmembrane transport
EP13_RS15700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EP13_RS15705	COG0733	neurotransmitter:sodium symporter activity
EP13_RS15720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EP13_RS15735	COG0716	FMN binding
EP13_RS15745	COG0848	biopolymer transport protein
EP13_RS15755	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EP13_RS15775	COG5002	protein histidine kinase activity
EP13_RS15775	COG5001	Diguanylate cyclase
EP13_RS15785	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EP13_RS15790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP13_RS15800	COG0583	DNA-binding transcription factor activity
EP13_RS15820	COG0121	glutamine amidotransferase
EP13_RS15845	COG1522	sequence-specific DNA binding
EP13_RS15855	COG0577	efflux transmembrane transporter activity
EP13_RS15855	COG1136	(ABC) transporter
EP13_RS15870	COG4628	conserved protein (DUF2132)
EP13_RS15880	COG3265	gluconokinase activity
EP13_RS15885	COG1609	Transcriptional regulator
EP13_RS15900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EP13_RS15910	COG1477	protein flavinylation
EP13_RS15915	COG2871	sodium ion transport
EP13_RS15920	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EP13_RS15925	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EP13_RS15930	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EP13_RS15935	COG1805	sodium ion transport
EP13_RS15940	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EP13_RS15945	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EP13_RS15950	COG0545	Peptidyl-prolyl cis-trans isomerase
EP13_RS15955	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EP13_RS15970	COG0039	L-malate dehydrogenase activity
EP13_RS15975	COG1438	arginine binding
EP13_RS15980	COG4206	TonB-dependent receptor
EP13_RS16005	COG0572	uridine kinase
EP13_RS16010	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EP13_RS16030	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EP13_RS16030	COG0517	IMP dehydrogenase activity
EP13_RS16035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP13_RS16045	COG0784	Response regulator, receiver
EP13_RS16045	COG2198	Histidine kinase
EP13_RS16045	COG5002	protein histidine kinase activity
EP13_RS16055	COG0189	ligase activity
EP13_RS16065	COG4067	protein conserved in archaea
EP13_RS16065	COG0189	ligase activity
EP13_RS16080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EP13_RS16090	COG1283	sodium-dependent phosphate transmembrane transporter activity
EP13_RS16095	COG0667	Aldo Keto reductase
EP13_RS16110	COG0753	catalase activity
EP13_RS16160	COG0583	DNA-binding transcription factor activity
EP13_RS16190	COG1216	Glycosyl transferase, family 2
EP13_RS16190	COG0438	transferase activity, transferring glycosyl groups
EP13_RS16200	COG1091	dTDP-4-dehydrorhamnose reductase activity
EP13_RS16220	COG1216	Glycosyl transferase, family 2
EP13_RS16225	COG1215	transferase activity, transferring glycosyl groups
EP13_RS16250	COG1215	transferase activity, transferring glycosyl groups
EP13_RS16260	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EP13_RS16260	COG0662	Cupin 2, conserved barrel domain protein
EP13_RS16270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP13_RS16280	COG0202	RNA polymerase activity
EP13_RS16300	COG0201	protein transport
EP13_RS16320	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EP13_RS16355	COG0784	Response regulator, receiver
EP13_RS16355	COG5002	protein histidine kinase activity
EP13_RS16365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP13_RS16385	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EP13_RS16410	COG2234	aminopeptidase activity
EP13_RS16450	COG1271	oxidase subunit
EP13_RS16455	COG1294	oxidase, subunit
EP13_RS16460	COG0840	transmembrane signaling receptor activity
EP13_RS16470	COG1278	Cold shock
EP13_RS16475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EP13_RS16495	COG0339	signal peptide processing
EP13_RS16500	COG0745	RESPONSE REGULATOR receiver
EP13_RS16510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP13_RS16510	COG4191	Histidine kinase
EP13_RS16520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP13_RS16525	COG1506	peptidase
EP13_RS16525	COG4946	Tricorn protease homolog
EP13_RS16525	COG0823	Involved in the tonB-independent uptake of proteins
EP13_RS16565	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EP13_RS16570	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EP13_RS16575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EP13_RS16590	COG0281	malic enzyme
EP13_RS16600	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EP13_RS16630	COG0456	acetyltransferase
EP13_RS16640	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EP13_RS16645	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EP13_RS16650	COG2177	Part of the ABC transporter FtsEX involved in
EP13_RS16655	COG2884	Cell division ATP-binding protein ftsE
EP13_RS16660	COG0552	protein localization to endoplasmic reticulum
EP13_RS16665	COG0742	ribosomal rna small subunit methyltransferase
EP13_RS16670	COG3068	Protein conserved in bacteria
EP13_RS16675	COG2095	MarC family integral membrane protein
EP13_RS16695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EP13_RS16710	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EP13_RS16725	COG0076	glutamate decarboxylase activity
EP13_RS16735	COG0842	Transport permease protein
EP13_RS16740	COG1131	(ABC) transporter
EP13_RS16750	COG0745	RESPONSE REGULATOR receiver
EP13_RS16755	COG2205	protein histidine kinase activity
EP13_RS16760	COG4774	siderophore transport
EP13_RS16780	COG1253	flavin adenine dinucleotide binding
EP13_RS16785	COG0701	Predicted permease
EP13_RS16790	COG1966	Carbon starvation protein
EP13_RS16800	COG0657	acetylesterase activity
EP13_RS16810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EP13_RS16815	COG0049	tRNA binding
EP13_RS16820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EP13_RS16825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EP13_RS16830	COG0085	RNA polymerase activity
EP13_RS16835	COG0222	ribosome binding
EP13_RS16840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EP13_RS16845	COG0081	regulation of translation
EP13_RS16850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EP13_RS16865	COG0250	Participates in transcription elongation, termination and antitermination
EP13_RS16870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EP13_RS16880	COG1132	(ABC) transporter
EP13_RS16885	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EP13_RS16895	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EP13_RS16900	COG3590	peptidase
EP13_RS16910	COG0513	Belongs to the DEAD box helicase family
EP13_RS16915	COG0418	dihydroorotase activity
EP13_RS16925	COG3040	lipid binding
EP13_RS16930	COG4989	oxidoreductase activity
EP13_RS16935	COG0346	lactoylglutathione lyase activity
EP13_RS16950	COG0302	gtp cyclohydrolase
EP13_RS16960	COG2957	Belongs to the agmatine deiminase family
EP13_RS16965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP13_RS16975	COG3706	GGDEF domain
EP13_RS17010	COG1201	RNA secondary structure unwinding
EP13_RS17020	COG1793	dna ligase
EP13_RS17040	COG0625	glutathione transferase activity
EP13_RS17050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EP13_RS17060	COG1012	belongs to the aldehyde dehydrogenase family
EP13_RS17065	COG0028	Belongs to the TPP enzyme family
EP13_RS17075	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EP13_RS17080	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EP13_RS17085	COG0330	HflC and HflK could
EP13_RS17090	COG0330	HflC and HflK could
EP13_RS17095	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EP13_RS17100	COG1923	regulation of RNA biosynthetic process
EP13_RS17105	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EP13_RS17110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EP13_RS17120	COG0802	atpase or kinase
EP13_RS17125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EP13_RS17125	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EP13_RS17130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EP13_RS17150	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EP13_RS17155	COG0735	belongs to the Fur family
EP13_RS17165	COG0432	Pfam Uncharacterised protein family UPF0047
EP13_RS17175	COG0305	Participates in initiation and elongation during chromosome replication
EP13_RS17200	COG2258	MOSC domain
EP13_RS17220	COG5002	protein histidine kinase activity
EP13_RS17230	COG0840	transmembrane signaling receptor activity
EP13_RS17235	COG4191	Histidine kinase
EP13_RS17245	COG1609	Transcriptional regulator
EP13_RS17250	COG2211	Major facilitator Superfamily
EP13_RS17255	COG2723	6-phospho-beta-galactosidase activity
EP13_RS17275	COG0789	Transcriptional regulator
EP13_RS17290	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EP13_RS17295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EP13_RS17300	COG4558	Periplasmic binding protein
EP13_RS17310	COG4771	TonB-dependent receptor
EP13_RS17335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EP13_RS17340	COG4988	ABC transporter
EP13_RS17350	COG1294	oxidase, subunit
EP13_RS17365	COG2204	response regulator
EP13_RS17450	COG2814	Major facilitator Superfamily
EP13_RS17460	COG3237	CsbD-like
EP13_RS17475	COG4771	TonB-dependent receptor
EP13_RS17480	COG0457	Tetratricopeptide repeat
EP13_RS17495	COG3314	Sporulation integral membrane protein YlbJ
EP13_RS17510	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EP13_RS17560	COG1595	DNA-templated transcription, initiation
EP13_RS17590	COG2267	carboxylic ester hydrolase activity
EP13_RS17610	COG1252	NADH dehydrogenase
EP13_RS17630	COG0583	DNA-binding transcription factor activity
EP13_RS17635	COG2067	long-chain fatty acid transport protein
EP13_RS17640	COG2130	NADP-dependent
EP13_RS17650	COG0784	Response regulator, receiver
EP13_RS17650	COG2205	protein histidine kinase activity
EP13_RS17660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP13_RS17670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EP13_RS17675	COG4771	TonB-dependent receptor
EP13_RS17680	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP13_RS17700	COG0656	L-ascorbic acid biosynthetic process
EP13_RS17705	COG2175	clavaminate synthase activity
EP13_RS17710	COG2855	membrane
EP13_RS17780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EP13_RS17785	COG1349	DNA-binding transcription factor activity
EP13_RS17790	COG0673	inositol 2-dehydrogenase activity
EP13_RS17805	COG0697	spore germination
EP13_RS17815	COG2169	Transcriptional regulator
EP13_RS17825	COG1166	arginine decarboxylase activity
EP13_RS17835	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EP13_RS17875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP13_RS17880	COG3507	Belongs to the glycosyl hydrolase 43 family
EP13_RS17885	COG0109	protoheme IX farnesyltransferase activity
EP13_RS17905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EP13_RS17920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EP13_RS17950	COG1335	isochorismatase
EP13_RS17955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP13_RS17970	COG3384	dioxygenase
EP13_RS17980	COG2175	clavaminate synthase activity
EP13_RS18000	COG1324	tolerance protein
EP13_RS18005	COG4232	protein-disulfide reductase activity
EP13_RS18010	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EP13_RS18015	COG0511	ligase activity, forming carbon-carbon bonds
EP13_RS18020	COG0439	Biotin carboxylase
EP13_RS18075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP13_RS18080	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EP13_RS18095	COG0151	Belongs to the GarS family
EP13_RS18105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP13_RS18115	COG3954	Phosphoribulokinase
EP13_RS18140	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EP13_RS18145	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EP13_RS18155	COG3031	protein transport across the cell outer membrane
EP13_RS18165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EP13_RS18170	COG1459	type II secretion system
EP13_RS18175	COG2165	general secretion pathway protein
EP13_RS18185	COG2165	general secretion pathway protein
EP13_RS18190	COG4795	General secretion pathway protein
EP13_RS18195	COG3156	type II secretion system protein K
EP13_RS18205	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EP13_RS18220	COG1012	belongs to the aldehyde dehydrogenase family
EP13_RS18230	COG1011	Hydrolase
EP13_RS18235	COG0494	nUDIX hydrolase
EP13_RS18240	COG1218	3'(2'),5'-bisphosphate nucleotidase
EP13_RS18250	COG2943	transferase activity, transferring hexosyl groups
EP13_RS18255	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EP13_RS18265	COG3089	Belongs to the UPF0270 family
EP13_RS18270	COG0429	hydrolase of the alpha beta-hydrolase fold
EP13_RS18280	COG0488	(ABC) transporter
EP13_RS18305	COG0545	Peptidyl-prolyl cis-trans isomerase
EP13_RS18315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EP13_RS18320	COG2183	response to ionizing radiation
EP13_RS18335	COG0596	Alpha beta hydrolase
EP13_RS18340	COG1040	competence protein
EP13_RS18360	COG1794	racemase activity, acting on amino acids and derivatives
EP13_RS18365	COG2226	methyltransferase
EP13_RS18375	COG0534	Mate efflux family protein
EP13_RS18395	COG0109	protoheme IX farnesyltransferase activity
EP13_RS18400	COG1612	heme a metabolic process
EP13_RS18420	COG1845	cytochrome c oxidase, subunit III
EP13_RS18430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EP13_RS18435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EP13_RS18445	COG4774	siderophore transport
EP13_RS18465	COG0129	dihydroxy-acid dehydratase activity
EP13_RS18470	COG2860	membrane
EP13_RS18475	COG0606	chelatase, subunit chli
EP13_RS18480	COG0583	DNA-binding transcription factor activity
EP13_RS18490	COG2814	Major facilitator Superfamily
EP13_RS18500	COG0729	surface antigen
EP13_RS18525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EP13_RS18535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EP13_RS18555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EP13_RS18600	COG0425	Belongs to the sulfur carrier protein TusA family
EP13_RS18615	COG1561	YicC-like family, N-terminal region
EP13_RS18630	COG3550	peptidyl-serine autophosphorylation
EP13_RS18650	COG2723	6-phospho-beta-galactosidase activity
EP13_RS18655	COG2211	Major facilitator Superfamily
EP13_RS18705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EP13_RS18725	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EP13_RS18730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EP13_RS18750	COG1475	DNA binding
EP13_RS18755	COG1192	Involved in chromosome partitioning
EP13_RS18780	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EP13_RS18785	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EP13_RS18795	COG0706	membrane insertase activity
EP13_RS18845	COG3209	COG3209 Rhs family protein
EP13_RS18915	COG2815	serine threonine protein kinase
EP13_RS18915	COG0515	serine threonine protein kinase
EP13_RS18930	COG2205	protein histidine kinase activity
EP13_RS18930	COG3437	response regulator, receiver
EP13_RS18930	COG3850	Histidine kinase
EP13_RS18930	COG4999	Histidine kinase
EP13_RS18955	COG0655	NAD(P)H dehydrogenase (quinone) activity
EP13_RS18965	COG4638	Rieske (2fe-2S)