locus-tag	class	description
I633_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I633_RS00020	COG0187	DNA topoisomerase II activity
I633_RS00040	COG2818	Glycosylase
I633_RS00050	COG3078	GTPase activator activity
I633_RS00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I633_RS00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I633_RS00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I633_RS00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I633_RS00110	COG0758	DNA mediated transformation
I633_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
I633_RS00130	COG0408	coproporphyrinogen oxidase activity
I633_RS00135	COG3047	cAMP biosynthetic process
I633_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I633_RS00235	COG2234	aminopeptidase activity
I633_RS00240	COG0463	Glycosyl transferase, family 2
I633_RS00250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I633_RS00275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I633_RS00305	COG3642	lipopolysaccharide core region biosynthetic process
I633_RS00340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I633_RS00355	COG3161	chorismate lyase activity
I633_RS00360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I633_RS00365	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I633_RS00380	COG0210	DNA helicase
I633_RS00410	COG1757	Na H antiporter
I633_RS00425	COG1959	2 iron, 2 sulfur cluster binding
I633_RS00430	COG0730	response to heat
I633_RS00445	COG4771	TonB-dependent receptor
I633_RS00460	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I633_RS00465	COG4988	ABC transporter
I633_RS00475	COG1271	oxidase subunit
I633_RS00490	COG0450	alkyl hydroperoxide reductase
I633_RS00500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I633_RS00530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I633_RS00535	COG0318	PFAM AMP-dependent synthetase and ligase
I633_RS00555	COG1024	Enoyl-CoA hydratase
I633_RS00610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_RS00615	COG0842	Transport permease protein
I633_RS00615	COG1129	ABC transporter
I633_RS00620	COG0842	Transport permease protein
I633_RS00655	COG0583	DNA-binding transcription factor activity
I633_RS00665	COG3106	COG3106 Predicted ATPase
I633_RS00680	COG2184	nucleotidyltransferase activity
I633_RS00685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I633_RS00700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I633_RS00715	COG3071	HemY protein
I633_RS00730	COG0181	hydroxymethylbilane synthase activity
I633_RS00755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I633_RS00765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I633_RS00770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I633_RS00780	COG0678	peroxiredoxin activity
I633_RS00795	COG1178	ABC-type Fe3 transport system permease component
I633_RS00800	COG3842	ATPase activity
I633_RS00830	COG2801	Transposase and inactivated derivatives
I633_RS00845	COG2200	EAL domain
I633_RS00850	COG0583	DNA-binding transcription factor activity
I633_RS00875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_RS00895	COG0123	including yeast histone deacetylase and acetoin utilization protein
I633_RS00910	COG0840	transmembrane signaling receptor activity
I633_RS00920	COG3064	Membrane
I633_RS00930	COG5001	Diguanylate cyclase
I633_RS00930	COG5002	protein histidine kinase activity
I633_RS00950	COG2239	Acts as a magnesium transporter
I633_RS00955	COG2962	Rard protein
I633_RS00975	COG1011	Hydrolase
I633_RS00990	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I633_RS00995	COG0019	diaminopimelate decarboxylase activity
I633_RS01025	COG0163	prenyltransferase activity
I633_RS01040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I633_RS01060	COG1077	Cell shape determining protein MreB Mrl
I633_RS01070	COG2814	Major facilitator Superfamily
I633_RS01075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I633_RS01115	COG0629	single-stranded DNA binding
I633_RS01130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I633_RS01190	COG3409	Peptidoglycan-binding domain 1 protein
I633_RS01190	COG3267	Type II secretory pathway component ExeA
I633_RS01200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I633_RS01205	COG1459	type II secretion system
I633_RS01220	COG2165	general secretion pathway protein
I633_RS01250	COG1077	Cell shape determining protein MreB Mrl
I633_RS01255	COG1792	Involved in formation and maintenance of cell shape
I633_RS01260	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I633_RS01270	COG1530	ribonuclease E activity
I633_RS01280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I633_RS01290	COG3028	Belongs to the UPF0307 family
I633_RS01310	COG0745	RESPONSE REGULATOR receiver
I633_RS01315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I633_RS01315	COG4191	Histidine kinase
I633_RS01320	COG0297	glycogen (starch) synthase activity
I633_RS01330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I633_RS01385	COG0531	amino acid
I633_RS01425	COG0745	RESPONSE REGULATOR receiver
I633_RS01435	COG0835	chemotaxis
I633_RS01450	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I633_RS01465	COG0745	RESPONSE REGULATOR receiver
I633_RS01475	COG0835	chemotaxis
I633_RS01495	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I633_RS01565	COG1609	Transcriptional regulator
I633_RS01570	COG0673	inositol 2-dehydrogenase activity
I633_RS01580	COG2211	Major facilitator Superfamily
I633_RS01585	COG1082	Xylose isomerase domain protein TIM barrel
I633_RS01605	COG1454	alcohol dehydrogenase
I633_RS01655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I633_RS01675	COG0089	rRNA binding
I633_RS01685	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I633_RS01695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I633_RS01710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I633_RS01715	COG0438	transferase activity, transferring glycosyl groups
I633_RS01745	COG0840	transmembrane signaling receptor activity
I633_RS01760	COG0788	formyltetrahydrofolate deformylase activity
I633_RS01790	COG2354	Protein conserved in bacteria
I633_RS01810	COG0004	ammonium transporteR
I633_RS01820	COG2837	iron assimilation
I633_RS01835	COG0540	Belongs to the ATCase OTCase family
I633_RS01885	COG1012	belongs to the aldehyde dehydrogenase family
I633_RS01895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I633_RS01910	COG0180	Tryptophanyl-tRNA synthetase
I633_RS01915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I633_RS01935	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I633_RS01945	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I633_RS01980	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I633_RS01985	COG0281	malic enzyme
I633_RS02005	COG0753	catalase activity
I633_RS02020	COG5001	Diguanylate cyclase
I633_RS02020	COG3300	MHYT domain
I633_RS02025	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I633_RS02025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I633_RS02035	COG0137	argininosuccinate synthase activity
I633_RS02055	COG1803	Methylglyoxal synthase
I633_RS02065	COG0745	RESPONSE REGULATOR receiver
I633_RS02070	COG2205	protein histidine kinase activity
I633_RS02075	COG2267	carboxylic ester hydrolase activity
I633_RS02080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I633_RS02090	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I633_RS02100	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I633_RS02105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I633_RS02110	COG4942	peptidase
I633_RS02115	COG2861	carbohydrate metabolic process
I633_RS02125	COG0584	glycerophosphoryl diester phosphodiesterase
I633_RS02145	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I633_RS02180	COG0028	Belongs to the TPP enzyme family
I633_RS02200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I633_RS02205	COG0805	protein transport
I633_RS02215	COG0084	hydrolase, TatD family'
I633_RS02220	COG3706	GGDEF domain
I633_RS02220	COG5001	Diguanylate cyclase
I633_RS02220	COG4251	negative regulation of phosphorylation
I633_RS02220	COG2203	Gaf domain
I633_RS02230	COG0248	Ppx GppA phosphatase
I633_RS02235	COG0513	Belongs to the DEAD box helicase family
I633_RS02240	COG3118	belongs to the thioredoxin family
I633_RS02245	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I633_RS02250	COG1473	amidohydrolase
I633_RS02255	COG5002	protein histidine kinase activity
I633_RS02255	COG0784	Response regulator, receiver
I633_RS02260	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I633_RS02265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I633_RS02270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I633_RS02285	COG0783	Belongs to the Dps family
I633_RS02290	COG2133	pyrroloquinoline quinone binding
I633_RS02305	COG3118	belongs to the thioredoxin family
I633_RS02320	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I633_RS02330	COG1012	belongs to the aldehyde dehydrogenase family
I633_RS02370	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I633_RS02380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I633_RS02390	COG0346	lactoylglutathione lyase activity
I633_RS02415	COG2824	Alkylphosphonate utilization operon protein PhnA
I633_RS02420	COG0454	-acetyltransferase
I633_RS02445	COG3093	addiction module antidote protein HigA
I633_RS02460	COG2026	Addiction module toxin, RelE StbE family
I633_RS02495	COG3093	addiction module antidote protein HigA
I633_RS02570	COG1024	Enoyl-CoA hydratase
I633_RS02570	COG1250	3-hydroxyacyl-CoA dehydrogenase
I633_RS02580	COG0006	proline dipeptidase activity
I633_RS02590	COG0142	geranyltranstransferase activity
I633_RS02625	COG1238	metal cluster binding
I633_RS02635	COG0585	pseudouridine synthase activity
I633_RS02640	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I633_RS02650	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I633_RS02710	COG0730	response to heat
I633_RS02715	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I633_RS02720	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I633_RS02765	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I633_RS02780	COG0513	Belongs to the DEAD box helicase family
I633_RS02795	COG1538	Outer membrane efflux protein
I633_RS02800	COG0494	nUDIX hydrolase
I633_RS02810	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I633_RS02815	COG3150	esterase
I633_RS02830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I633_RS02855	COG1509	lysine 2,3-aminomutase activity
I633_RS02860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I633_RS02865	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I633_RS02880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I633_RS02885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I633_RS02900	COG0271	Belongs to the BolA IbaG family
I633_RS02915	COG3707	response regulator
I633_RS02925	COG0659	secondary active sulfate transmembrane transporter activity
I633_RS02945	COG0243	molybdopterin cofactor binding
I633_RS02950	COG1648	precorrin-2 dehydrogenase activity
I633_RS02950	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I633_RS02955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I633_RS02965	COG1116	anion transmembrane transporter activity
I633_RS02965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I633_RS02990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I633_RS03005	COG0348	domain, Protein
I633_RS03020	COG1960	acyl-CoA dehydrogenase activity
I633_RS03025	COG1028	Short-chain dehydrogenase reductase Sdr
I633_RS03035	COG4948	Mandelate Racemase Muconate Lactonizing
I633_RS03050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_RS03080	COG0358	DNA primase activity
I633_RS03105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I633_RS03110	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I633_RS03125	COG0537	adenosine 5'-monophosphoramidase activity
I633_RS03140	COG3135	benzoate transporter
I633_RS03145	COG1396	sequence-specific DNA binding
I633_RS03155	COG4191	Histidine kinase
I633_RS03155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I633_RS03160	COG0745	RESPONSE REGULATOR receiver
I633_RS03165	COG5002	protein histidine kinase activity
I633_RS03190	COG0811	peptide transport
I633_RS03200	COG0848	biopolymer transport protein
I633_RS03205	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I633_RS03215	COG3437	response regulator, receiver
I633_RS03235	COG2133	pyrroloquinoline quinone binding
I633_RS03240	COG1049	propionate catabolic process, 2-methylcitrate cycle
I633_RS03245	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I633_RS03280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I633_RS03285	COG2967	ApaG domain
I633_RS03295	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I633_RS03300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I633_RS03305	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I633_RS03310	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I633_RS03320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I633_RS03340	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I633_RS03385	COG1028	Short-chain dehydrogenase reductase Sdr
I633_RS03395	COG0318	PFAM AMP-dependent synthetase and ligase
I633_RS03415	COG0463	Glycosyl transferase, family 2
I633_RS03435	COG0642	Histidine kinase
I633_RS03455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I633_RS03460	COG0723	plastoquinol--plastocyanin reductase activity
I633_RS03465	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I633_RS03475	COG0625	glutathione transferase activity
I633_RS03480	COG2969	positive regulation of protein catabolic process
I633_RS03485	COG2239	Acts as a magnesium transporter
I633_RS03490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I633_RS03515	COG1137	ATPase activity
I633_RS03520	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I633_RS03530	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I633_RS03550	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I633_RS03555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I633_RS03560	COG2854	intermembrane phospholipid transfer
I633_RS03570	COG5007	Belongs to the BolA IbaG family
I633_RS03585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I633_RS03645	COG0697	spore germination
I633_RS03655	COG0784	Response regulator, receiver
I633_RS03655	COG2205	protein histidine kinase activity
I633_RS03680	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I633_RS03690	COG0126	phosphoglycerate kinase activity
I633_RS03695	COG3588	fructose-bisphosphate aldolase
I633_RS03705	COG4946	Tricorn protease homolog
I633_RS03705	COG1506	peptidase
I633_RS03705	COG0823	Involved in the tonB-independent uptake of proteins
I633_RS03715	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I633_RS03725	COG0573	inorganic phosphate transmembrane transporter activity
I633_RS03735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I633_RS03755	COG0583	DNA-binding transcription factor activity
I633_RS03765	COG1272	protein, Hemolysin III
I633_RS03770	COG1846	Transcriptional regulator
I633_RS03775	COG1764	response to oxidative stress
I633_RS03790	COG1739	Uncharacterized protein family UPF0029
I633_RS03800	COG0420	3'-5' exonuclease activity
I633_RS03815	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I633_RS03840	COG2986	histidine ammonia-lyase
I633_RS03865	COG0488	(ABC) transporter
I633_RS03885	COG0668	transmembrane transport
I633_RS03915	COG0582	viral genome integration into host DNA
I633_RS03985	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I633_RS04035	COG1346	cytolysis
I633_RS04065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I633_RS04075	COG0513	Belongs to the DEAD box helicase family
I633_RS04100	COG0066	3-isopropylmalate dehydratase activity
I633_RS04110	COG0473	3-isopropylmalate dehydrogenase activity
I633_RS04115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I633_RS04135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I633_RS04150	COG4555	ABC transporter
I633_RS04155	COG1668	transmembrane transport
I633_RS04180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I633_RS04185	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I633_RS04200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I633_RS04215	COG2853	Lipoprotein
I633_RS04220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I633_RS04260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I633_RS04275	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I633_RS04280	COG1596	polysaccharide export
I633_RS04280	COG1555	photosystem II stabilization
I633_RS04285	COG0473	3-isopropylmalate dehydrogenase activity
I633_RS04300	COG1611	Belongs to the LOG family
I633_RS04405	COG1773	rubredoxin
I633_RS04435	COG2204	response regulator
I633_RS04445	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I633_RS04510	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I633_RS04515	COG0024	Methionine aminopeptidase
I633_RS04520	COG0052	Belongs to the universal ribosomal protein uS2 family
I633_RS04530	COG0528	UMP kinase activity
I633_RS04570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I633_RS04595	COG0825	malonyl-CoA metabolic process
I633_RS04600	COG0037	tRNA processing
I633_RS04635	COG2840	Smr protein MutS2
I633_RS04665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_RS04670	COG2197	response regulator
I633_RS04710	COG0835	chemotaxis
I633_RS04710	COG0784	Response regulator, receiver
I633_RS04715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I633_RS04720	COG1815	bacterial-type flagellum-dependent cell motility
I633_RS04740	COG4787	bacterial-type flagellum-dependent cell motility
I633_RS04760	COG1705	Flagellar rod assembly protein muramidase FlgJ
I633_RS04760	COG3951	Flagellar rod assembly protein muramidase FlgJ
I633_RS04765	COG1256	bacterial-type flagellum assembly
I633_RS04795	COG1334	flagellar protein FlaG
I633_RS04800	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I633_RS04830	COG3980	spore coat polysaccharide biosynthesis protein
I633_RS04835	COG1083	cytidylyl-transferase
I633_RS04840	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I633_RS04870	COG1677	Flagellar hook-basal body complex protein FliE
I633_RS04880	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I633_RS04945	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I633_RS04970	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I633_RS04975	COG2198	Histidine kinase
I633_RS04975	COG0643	Histidine kinase
I633_RS04975	COG0784	Response regulator, receiver
I633_RS04995	COG0835	chemotaxis
I633_RS05010	COG0646	methionine synthase
I633_RS05010	COG1410	methionine synthase
I633_RS05015	COG1410	methionine synthase
I633_RS05015	COG0646	methionine synthase
I633_RS05030	COG0583	DNA-binding transcription factor activity
I633_RS05035	COG0583	DNA-binding transcription factor activity
I633_RS05040	COG0288	reversible hydration of carbon dioxide
I633_RS05060	COG3590	peptidase
I633_RS05070	COG2137	regulation of response to DNA damage stimulus
I633_RS05110	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I633_RS05115	COG4172	Belongs to the ABC transporter superfamily
I633_RS05125	COG4171	peptide transport system, permease
I633_RS05130	COG4168	peptide transport system, permease
I633_RS05140	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I633_RS05145	COG1842	Phage shock protein A
I633_RS05175	COG0625	glutathione transferase activity
I633_RS05180	COG1522	sequence-specific DNA binding
I633_RS05245	COG0811	peptide transport
I633_RS05255	COG0848	biopolymer transport protein
I633_RS05270	COG1444	tRNA N-acetyltransferase activity
I633_RS05310	COG0456	acetyltransferase
I633_RS05325	COG0583	DNA-binding transcription factor activity
I633_RS05335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I633_RS05340	COG0656	L-ascorbic acid biosynthetic process
I633_RS05360	COG1846	Transcriptional regulator
I633_RS05460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I633_RS05495	COG0543	2 iron, 2 sulfur cluster binding
I633_RS05495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I633_RS05510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I633_RS05515	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I633_RS05520	COG0564	pseudouridine synthase activity
I633_RS05530	COG0612	Peptidase, M16
I633_RS05575	COG2719	SpoVR family
I633_RS05580	COG2718	Belongs to the UPF0229 family
I633_RS05590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I633_RS05595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I633_RS05600	COG4771	TonB-dependent receptor
I633_RS05625	COG0450	alkyl hydroperoxide reductase
I633_RS05630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I633_RS05635	COG2885	chlorophyll binding
I633_RS05640	COG0584	glycerophosphoryl diester phosphodiesterase
I633_RS05645	COG0346	lactoylglutathione lyase activity
I633_RS05650	COG1278	Cold shock
I633_RS05665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I633_RS05670	COG4660	Part of a membrane complex involved in electron transport
I633_RS05675	COG4659	FMN binding
I633_RS05685	COG4656	Part of a membrane complex involved in electron transport
I633_RS05690	COG2878	Part of a membrane complex involved in electron transport
I633_RS05695	COG4657	Part of a membrane complex involved in electron transport
I633_RS05715	COG0556	nucleotide-excision repair
I633_RS05730	COG0602	queuosine metabolic process
I633_RS05740	COG0367	asparagine synthase
I633_RS05765	COG0471	metal ion transport
I633_RS05765	COG3273	potassium ion transport
I633_RS05780	COG0529	Catalyzes the synthesis of activated sulfate
I633_RS05785	COG0175	sulfate reduction
I633_RS05790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I633_RS05795	COG2199	diguanylate cyclase activity
I633_RS05795	COG2203	Gaf domain
I633_RS05820	COG2304	oxidoreductase activity
I633_RS05840	COG0714	Associated with various cellular activities
I633_RS05865	COG1025	Belongs to the peptidase M16 family
I633_RS05870	COG2062	phosphohistidine phosphatase, SixA
I633_RS05880	COG4536	flavin adenine dinucleotide binding
I633_RS05885	COG4137	Cytochrome C assembly protein
I633_RS05890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I633_RS05955	COG0228	four-way junction DNA binding
I633_RS05960	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I633_RS05965	COG0336	Belongs to the RNA methyltransferase TrmD family
I633_RS05970	COG0335	large ribosomal subunit rRNA binding
I633_RS05975	COG2860	membrane
I633_RS05985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I633_RS05990	COG1605	Chorismate mutase
I633_RS05990	COG0287	Prephenate dehydrogenase
I633_RS05995	COG0077	Prephenate dehydratase
I633_RS05995	COG1605	Chorismate mutase
I633_RS06000	COG0745	RESPONSE REGULATOR receiver
I633_RS06005	COG0023	Translation Initiation Factor
I633_RS06035	COG2205	protein histidine kinase activity
I633_RS06045	COG2204	response regulator
I633_RS06070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I633_RS06075	COG0494	nUDIX hydrolase
I633_RS06080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I633_RS06085	COG0632	four-way junction helicase activity
I633_RS06090	COG2255	four-way junction helicase activity
I633_RS06095	COG0824	Thioesterase
I633_RS06100	COG0811	peptide transport
I633_RS06120	COG2885	chlorophyll binding
I633_RS06125	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I633_RS06145	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I633_RS06165	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I633_RS06185	COG3038	cytochrome b561
I633_RS06210	COG0583	DNA-binding transcription factor activity
I633_RS06215	COG1451	nucleotide metabolic process
I633_RS06225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I633_RS06235	COG1309	transcriptional regulator
I633_RS06240	COG4774	siderophore transport
I633_RS06260	COG3706	GGDEF domain
I633_RS06270	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I633_RS06270	COG3008	intermembrane lipid transfer
I633_RS06290	COG0017	Asparaginyl-tRNA synthetase
I633_RS06305	COG0189	ligase activity
I633_RS06340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I633_RS06350	COG3340	Belongs to the peptidase S51 family
I633_RS06355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I633_RS06360	COG4139	cobalamin transport
I633_RS06385	COG5265	(ABC) transporter
I633_RS06390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I633_RS06400	COG0745	RESPONSE REGULATOR receiver
I633_RS06420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I633_RS06460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I633_RS06475	COG2755	lipolytic protein G-D-S-L family
I633_RS06480	COG4181	ATPase activity
I633_RS06485	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I633_RS06490	COG1090	epimerase
I633_RS06495	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I633_RS06500	COG0628	permease
I633_RS06525	COG2350	Protein conserved in bacteria
I633_RS06530	COG0159	tryptophan synthase activity
I633_RS06540	COG0134	indole-3-glycerol-phosphate synthase activity
I633_RS06540	COG0135	phosphoribosylanthranilate isomerase activity
I633_RS06545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I633_RS06555	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I633_RS06560	COG0613	PHP domain protein
I633_RS06565	COG0009	L-threonylcarbamoyladenylate synthase
I633_RS06575	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I633_RS06585	COG0656	L-ascorbic acid biosynthetic process
I633_RS06590	COG0110	maltose O-acetyltransferase activity
I633_RS06620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_RS06625	COG0500	methyltransferase
I633_RS06630	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I633_RS06635	COG0497	DNA recombination
I633_RS06640	COG0783	Belongs to the Dps family
I633_RS06645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I633_RS06650	COG1454	alcohol dehydrogenase
I633_RS06655	COG1028	Short-chain dehydrogenase reductase Sdr
I633_RS06665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I633_RS06670	COG2610	gluconate transmembrane transporter activity
I633_RS06685	COG2205	protein histidine kinase activity
I633_RS06685	COG0784	Response regulator, receiver
I633_RS06685	COG2198	Histidine kinase
I633_RS06690	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I633_RS06700	COG0484	heat shock protein binding
I633_RS06705	COG3909	cytochrome
I633_RS06710	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I633_RS06725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I633_RS06740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I633_RS06780	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I633_RS06785	COG4535	Mg2 and Co2 transporter CorC
I633_RS06795	COG1702	phosphate starvation-inducible protein PhoH
I633_RS06830	COG1607	acyl-coa hydrolase
I633_RS06835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I633_RS06845	COG1115	amino acid carrier protein
I633_RS06895	COG0012	GTP binding
I633_RS06910	COG1064	alcohol dehydrogenase
I633_RS06925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I633_RS06935	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I633_RS06940	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I633_RS06955	COG2890	protein-(glutamine-N5) methyltransferase activity
I633_RS06960	COG0784	Response regulator, receiver
I633_RS06960	COG3437	response regulator, receiver
I633_RS06970	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I633_RS06990	COG2363	Small membrane protein
I633_RS07010	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I633_RS07015	COG0515	serine threonine protein kinase
I633_RS07035	COG0714	Associated with various cellular activities
I633_RS07040	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I633_RS07045	COG0033	Phosphoglucomutase
I633_RS07095	COG1393	Belongs to the ArsC family
I633_RS07120	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I633_RS07150	COG5001	Diguanylate cyclase
I633_RS07150	COG3300	MHYT domain
I633_RS07175	COG2249	NAD(P)H dehydrogenase (quinone) activity
I633_RS07195	COG1733	regulation of RNA biosynthetic process
I633_RS07200	COG3447	MASE1 domain protein
I633_RS07200	COG5002	protein histidine kinase activity
I633_RS07200	COG5001	Diguanylate cyclase
I633_RS07210	COG0402	S-adenosylhomocysteine deaminase activity
I633_RS07215	COG2351	hydroxyisourate hydrolase activity
I633_RS07230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I633_RS07240	COG1309	transcriptional regulator
I633_RS07260	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I633_RS07275	COG4251	negative regulation of phosphorylation
I633_RS07275	COG3706	GGDEF domain
I633_RS07275	COG2203	Gaf domain
I633_RS07275	COG5001	Diguanylate cyclase
I633_RS07285	COG2205	protein histidine kinase activity
I633_RS07285	COG0784	Response regulator, receiver
I633_RS07300	COG2233	PERMEase
I633_RS07320	COG0730	response to heat
I633_RS07360	COG1028	Short-chain dehydrogenase reductase Sdr
I633_RS07365	COG3001	Fructosamine kinase
I633_RS07375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I633_RS07405	COG1596	polysaccharide export
I633_RS07410	COG0489	protein tyrosine kinase activity
I633_RS07415	COG4464	protein tyrosine phosphatase activity
I633_RS07475	COG1216	Glycosyl transferase, family 2
I633_RS07495	COG1215	transferase activity, transferring glycosyl groups
I633_RS07505	COG2755	lipolytic protein G-D-S-L family
I633_RS07505	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I633_RS07510	COG1215	transferase activity, transferring glycosyl groups
I633_RS07515	COG0438	transferase activity, transferring glycosyl groups
I633_RS07525	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I633_RS07540	COG0072	phenylalanine-tRNA ligase activity
I633_RS07540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I633_RS07565	COG1472	Belongs to the glycosyl hydrolase 3 family
I633_RS07570	COG2096	Adenosyltransferase
I633_RS07590	COG4591	ABC-type transport system involved in lipoprotein release permease component
I633_RS07650	COG2814	Major facilitator Superfamily
I633_RS07685	COG4770	biotin carboxylase activity
I633_RS07690	COG1024	Enoyl-CoA hydratase
I633_RS07695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I633_RS07700	COG1960	acyl-CoA dehydrogenase activity
I633_RS07705	COG0789	Transcriptional regulator
I633_RS07725	COG3706	GGDEF domain
I633_RS07810	COG0328	RNA-DNA hybrid ribonuclease activity
I633_RS07815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I633_RS07845	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I633_RS07850	COG1136	(ABC) transporter
I633_RS07855	COG4591	ABC-type transport system involved in lipoprotein release permease component
I633_RS07870	COG3724	N-succinylarginine dihydrolase activity
I633_RS07890	COG0746	molybdenum cofactor guanylyltransferase activity
I633_RS07900	COG0243	molybdopterin cofactor binding
I633_RS07905	COG2153	protein acetylation
I633_RS07920	COG1530	ribonuclease E activity
I633_RS07925	COG0564	pseudouridine synthase activity
I633_RS07935	COG0424	maF-like protein
I633_RS07940	COG1399	metal-binding, possibly nucleic acid-binding protein
I633_RS07950	COG0416	fatty acid biosynthetic process
I633_RS07960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I633_RS07970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I633_RS07975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I633_RS07985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I633_RS08000	COG0084	hydrolase, TatD family'
I633_RS08010	COG0702	epimerase
I633_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
I633_RS08040	COG0596	Alpha beta hydrolase
I633_RS08050	COG0183	Belongs to the thiolase family
I633_RS08055	COG1960	acyl-CoA dehydrogenase activity
I633_RS08075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I633_RS08085	COG0246	Mannitol dehydrogenase
I633_RS08115	COG4771	TonB-dependent receptor
I633_RS08145	COG3437	response regulator, receiver
I633_RS08170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I633_RS08180	COG1187	pseudouridine synthase activity
I633_RS08190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I633_RS08190	COG3153	acetyltransferase
I633_RS08285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I633_RS08295	COG4134	Bacterial extracellular solute-binding protein
I633_RS08305	COG4136	ATPase activity
I633_RS08310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I633_RS08330	COG2203	Gaf domain
I633_RS08330	COG3706	GGDEF domain
I633_RS08330	COG4251	negative regulation of phosphorylation
I633_RS08330	COG5001	Diguanylate cyclase
I633_RS08445	COG1902	pentaerythritol trinitrate reductase activity
I633_RS08455	COG2867	negative regulation of translational initiation
I633_RS08460	COG2914	Belongs to the UPF0125 (RnfH) family
I633_RS08475	COG4771	TonB-dependent receptor
I633_RS08495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I633_RS08495	COG0574	Belongs to the PEP-utilizing enzyme family
I633_RS08530	COG2850	peptidyl-arginine hydroxylation
I633_RS08545	COG2915	High frequency lysogenization protein hflD homolog
I633_RS08550	COG0482	sulfurtransferase activity
I633_RS08565	COG1278	Cold shock
I633_RS08570	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I633_RS08575	COG0542	response to heat
I633_RS08580	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I633_RS08585	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I633_RS08590	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I633_RS08595	COG0492	ferredoxin-NADP+ reductase activity
I633_RS08605	COG3091	SprT-like family
I633_RS08625	COG0778	Nitroreductase
I633_RS08635	COG0252	asparaginase activity
I633_RS08640	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I633_RS08645	COG0321	lipoyl(octanoyl) transferase activity
I633_RS08650	COG2921	Belongs to the UPF0250 family
I633_RS08655	COG1686	Belongs to the peptidase S11 family
I633_RS08665	COG0772	Belongs to the SEDS family
I633_RS08675	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I633_RS08680	COG0799	negative regulation of ribosome biogenesis
I633_RS08690	COG1466	dna polymerase III delta subunit
I633_RS08695	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I633_RS08700	COG0495	leucyl-tRNA aminoacylation
I633_RS08710	COG0596	Alpha beta hydrolase
I633_RS08725	COG1534	Rna-binding protein
I633_RS08730	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I633_RS08735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I633_RS08740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I633_RS08745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I633_RS08750	COG0149	triose-phosphate isomerase activity
I633_RS08755	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I633_RS08765	COG5001	Diguanylate cyclase
I633_RS08765	COG3300	MHYT domain
I633_RS08785	COG1597	lipid kinase activity
I633_RS08785	COG1803	Methylglyoxal synthase
I633_RS08795	COG1028	Short-chain dehydrogenase reductase Sdr
I633_RS08800	COG0561	phosphatase activity
I633_RS08815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I633_RS08820	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I633_RS08825	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I633_RS08840	COG1185	polyribonucleotide nucleotidyltransferase activity
I633_RS09020	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I633_RS09025	COG1196	nuclear chromosome segregation
I633_RS09035	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I633_RS09050	COG1132	(ABC) transporter
I633_RS09055	COG1663	tetraacyldisaccharide 4'-kinase activity
I633_RS09090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I633_RS09095	COG0435	Glutathione S-transferase
I633_RS09100	COG1741	Belongs to the pirin family
I633_RS09105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I633_RS09115	COG0372	Belongs to the citrate synthase family
I633_RS09125	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I633_RS09130	COG1053	succinate dehydrogenase
I633_RS09135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I633_RS09140	COG0567	Dehydrogenase, E1 component
I633_RS09145	COG0508	dehydrogenase complex catalyzes the overall conversion of
I633_RS09180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I633_RS09185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I633_RS09200	COG4191	Histidine kinase
I633_RS09240	COG0366	Alpha amylase catalytic
I633_RS09265	COG1028	Short-chain dehydrogenase reductase Sdr
I633_RS09270	COG2267	carboxylic ester hydrolase activity
I633_RS09280	COG0616	signal peptide processing
I633_RS09300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I633_RS09305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I633_RS09310	COG0386	Belongs to the glutathione peroxidase family
I633_RS09315	COG2084	Dehydrogenase
I633_RS09330	COG1024	Enoyl-CoA hydratase
I633_RS09335	COG2226	methyltransferase
I633_RS09340	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I633_RS09345	COG3083	sulfuric ester hydrolase activity
I633_RS09350	COG3082	Protein of unknown function (DUF1414)
I633_RS09355	COG3081	Nucleoid-associated protein
I633_RS09385	COG3275	phosphorelay sensor kinase activity
I633_RS09390	COG3279	Response regulator of the LytR AlgR family
I633_RS09395	COG0205	6-phosphofructokinase activity
I633_RS09410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I633_RS09425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I633_RS09425	COG2205	protein histidine kinase activity
I633_RS09435	COG1054	Belongs to the UPF0176 family
I633_RS09445	COG0513	Belongs to the DEAD box helicase family
I633_RS09455	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I633_RS09460	COG0583	DNA-binding transcription factor activity
I633_RS09480	COG1760	l-serine dehydratase
I633_RS09505	COG1322	Protein conserved in bacteria
I633_RS09515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I633_RS09520	COG0022	dehydrogenase e1 component
I633_RS09540	COG1946	Acyl-CoA thioesterase
I633_RS09560	COG1956	GAF domain-containing protein
I633_RS09585	COG1757	Na H antiporter
I633_RS09590	COG0308	aminopeptidase N
I633_RS09625	COG0167	dihydroorotate dehydrogenase activity
I633_RS09640	COG0488	(ABC) transporter
I633_RS09650	COG3130	regulation of translation
I633_RS09665	COG0415	Belongs to the DNA photolyase family
I633_RS09680	COG3046	protein related to deoxyribodipyrimidine photolyase
I633_RS09815	COG4772	TonB-dependent receptor
I633_RS09870	COG4974	Belongs to the 'phage' integrase family
I633_RS09880	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I633_RS09885	COG0589	response to stress
I633_RS09895	COG0069	glutamate synthase activity
I633_RS09910	COG2193	ferroxidase activity
I633_RS09935	COG2010	Cytochrome c
I633_RS09960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I633_RS09965	COG0589	response to stress
I633_RS09970	COG0037	tRNA processing
I633_RS09975	COG1752	Esterase of the alpha-beta hydrolase superfamily
I633_RS09995	COG1280	lysine exporter protein (LysE YggA)
I633_RS10005	COG2897	thiosulfate sulfurtransferase activity
I633_RS10010	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I633_RS10015	COG3148	PFAM DTW domain containing protein
I633_RS10040	COG0322	excinuclease ABC activity
I633_RS10050	COG0436	Aminotransferase
I633_RS10055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I633_RS10065	COG2259	Doxx family
I633_RS10070	COG0583	DNA-binding transcription factor activity
I633_RS10085	COG0670	Belongs to the BI1 family
I633_RS10090	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I633_RS10105	COG2920	part of a sulfur-relay system
I633_RS10125	COG4206	TonB-dependent receptor
I633_RS10125	COG4206	TonB-dependent receptor
I633_RS10140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I633_RS10160	COG0686	Belongs to the AlaDH PNT family
I633_RS10165	COG0284	orotidine-5'-phosphate decarboxylase activity
I633_RS10170	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I633_RS10185	COG0776	regulation of translation
I633_RS10190	COG0539	negative regulation of cytoplasmic translation
I633_RS10195	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I633_RS10200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I633_RS10205	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I633_RS10215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I633_RS10225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I633_RS10230	COG0633	Ferredoxin
I633_RS10260	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I633_RS10265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I633_RS10275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I633_RS10285	COG4783	chaperone-mediated protein folding
I633_RS10295	COG1393	Belongs to the ArsC family
I633_RS10310	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I633_RS10325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I633_RS10360	COG0572	uridine kinase
I633_RS10365	COG3769	mannosylglycerate metabolic process
I633_RS10370	COG1215	transferase activity, transferring glycosyl groups
I633_RS10385	COG0303	'Molybdopterin
I633_RS10405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I633_RS10410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I633_RS10435	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I633_RS10490	COG1024	Enoyl-CoA hydratase
I633_RS10545	COG1671	Belongs to the UPF0178 family
I633_RS10555	COG1028	Short-chain dehydrogenase reductase Sdr
I633_RS10560	COG1960	acyl-CoA dehydrogenase activity
I633_RS10565	COG0662	Cupin 2, conserved barrel domain protein
I633_RS10565	COG2207	Transcriptional regulator
I633_RS10580	COG1505	serine-type exopeptidase activity
I633_RS10590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_RS10620	COG0596	Alpha beta hydrolase
I633_RS10630	COG0716	FMN binding
I633_RS10640	COG0735	belongs to the Fur family
I633_RS10650	COG1984	allophanate hydrolase subunit 2
I633_RS10660	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I633_RS10665	COG2996	Protein conserved in bacteria
I633_RS10675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_RS10700	COG0436	Aminotransferase
I633_RS10710	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I633_RS10730	COG2080	2 iron, 2 sulfur cluster binding
I633_RS10755	COG1073	alpha beta
I633_RS10760	COG2207	Transcriptional regulator
I633_RS10765	COG4584	PFAM Integrase catalytic
I633_RS10780	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I633_RS10785	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I633_RS10810	COG3012	SEC-C Motif Domain Protein
I633_RS10825	COG1960	acyl-CoA dehydrogenase activity
I633_RS10835	COG4771	TonB-dependent receptor
I633_RS10880	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I633_RS10885	COG0315	cyclic pyranopterin monophosphate synthase activity
I633_RS10890	COG0521	Mo-molybdopterin cofactor biosynthetic process
I633_RS10905	COG2161	toxin-antitoxin pair type II binding
I633_RS10910	COG4115	mRNA cleavage
I633_RS10930	COG3268	Saccharopine dehydrogenase
I633_RS10950	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I633_RS10955	COG4206	TonB-dependent receptor
I633_RS10970	COG5006	permease, DMT superfamily
I633_RS10995	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I633_RS11005	COG1022	Amp-dependent synthetase and ligase
I633_RS11030	COG0583	DNA-binding transcription factor activity
I633_RS11045	COG0640	Transcriptional regulator
I633_RS11065	COG2204	response regulator
I633_RS11075	COG4251	negative regulation of phosphorylation
I633_RS11080	COG0784	Response regulator, receiver
I633_RS11085	COG0784	Response regulator, receiver
I633_RS11085	COG2205	protein histidine kinase activity
I633_RS11110	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I633_RS11135	COG3139	Protein of unknown function (DUF1315)
I633_RS11150	COG1115	amino acid carrier protein
I633_RS11175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I633_RS11190	COG1640	4-alpha-glucanotransferase
I633_RS11195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I633_RS11200	COG0676	glucose-6-phosphate 1-epimerase activity
I633_RS11205	COG0800	Aldolase
I633_RS11215	COG0129	dihydroxy-acid dehydratase activity
I633_RS11225	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I633_RS11230	COG1737	Transcriptional regulator
I633_RS11235	COG0469	pyruvate kinase activity
I633_RS11260	COG2823	Periplasmic or secreted lipoprotein
I633_RS11285	COG3665	Urea carboxylase-associated protein
I633_RS11305	COG1028	Short-chain dehydrogenase reductase Sdr
I633_RS11310	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I633_RS11320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I633_RS11335	COG2721	sulfolactate sulfo-lyase activity
I633_RS11340	COG1904	glucuronate isomerase
I633_RS11355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I633_RS11405	COG0840	transmembrane signaling receptor activity
I633_RS11420	COG0583	DNA-binding transcription factor activity
I633_RS11425	COG1979	alcohol dehydrogenase
I633_RS11430	COG5001	Diguanylate cyclase
I633_RS11440	COG0784	Response regulator, receiver
I633_RS11440	COG3437	response regulator, receiver
I633_RS11480	COG0489	protein tyrosine kinase activity
I633_RS11485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I633_RS11485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I633_RS11490	COG0668	transmembrane transport
I633_RS11495	COG2226	methyltransferase
I633_RS11500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I633_RS11505	COG0741	lytic transglycosylase activity
I633_RS11505	COG1388	LysM domain
I633_RS11520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I633_RS11525	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I633_RS11535	COG2268	Band 7 protein
I633_RS11550	COG1733	regulation of RNA biosynthetic process
I633_RS11555	COG0604	alcohol dehydrogenase
I633_RS11560	COG0753	catalase activity
I633_RS11565	COG0604	alcohol dehydrogenase
I633_RS11595	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I633_RS11600	COG1286	toxin biosynthetic process
I633_RS11605	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I633_RS11610	COG0285	dihydrofolate synthase activity
I633_RS11630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I633_RS11635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I633_RS11655	COG3609	addiction module antidote protein, CC2985 family
I633_RS11660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I633_RS11665	COG0318	PFAM AMP-dependent synthetase and ligase
I633_RS11675	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I633_RS11675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I633_RS11715	COG0604	alcohol dehydrogenase
I633_RS11735	COG2031	fatty acid transporter
I633_RS11750	COG0612	Peptidase, M16
I633_RS11765	COG3101	peptidyl-lysine hydroxylation
I633_RS11795	COG1902	pentaerythritol trinitrate reductase activity
I633_RS11795	COG0446	pyridine nucleotide-disulphide oxidoreductase
I633_RS11830	COG4399	Belongs to the UPF0754 family
I633_RS11855	COG1770	oligopeptidase
I633_RS11870	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I633_RS11875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I633_RS11885	COG2983	Belongs to the UPF0260 family
I633_RS11890	COG0179	Fumarylacetoacetate (FAA) hydrolase
I633_RS11905	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I633_RS11915	COG2267	carboxylic ester hydrolase activity
I633_RS11930	COG1214	PFAM Peptidase M22, glycoprotease
I633_RS11985	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I633_RS12000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I633_RS12005	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I633_RS12010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I633_RS12020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I633_RS12035	COG0140	phosphoribosyl-ATP diphosphatase activity
I633_RS12035	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I633_RS12075	COG0326	Molecular chaperone. Has ATPase activity
I633_RS12080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I633_RS12100	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I633_RS12105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I633_RS12115	COG3220	belongs to the UPF0276 family
I633_RS12125	COG0577	efflux transmembrane transporter activity
I633_RS12125	COG1136	(ABC) transporter
I633_RS12165	COG1183	phosphatidylcholine synthase activity
I633_RS12185	COG0277	FAD linked oxidase domain protein
I633_RS12190	COG0542	response to heat
I633_RS12215	COG1595	DNA-templated transcription, initiation
I633_RS12230	COG4221	oxidoreductase activity
I633_RS12245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I633_RS12255	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I633_RS12275	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I633_RS12290	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I633_RS12305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I633_RS12305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I633_RS12320	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I633_RS12355	COG0084	hydrolase, TatD family'
I633_RS12370	COG0571	ribonuclease III activity
I633_RS12400	COG1595	DNA-templated transcription, initiation
I633_RS12405	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I633_RS12420	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I633_RS12500	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I633_RS12520	COG0196	riboflavin kinase activity
I633_RS12525	COG0728	peptidoglycan biosynthetic process
I633_RS12530	COG0268	Binds directly to 16S ribosomal RNA
I633_RS12550	COG0385	Bile acid
I633_RS12555	COG0583	DNA-binding transcription factor activity
I633_RS12590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I633_RS12595	COG0776	regulation of translation
I633_RS12600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I633_RS12610	COG0740	serine-type endopeptidase activity
I633_RS12615	COG0544	peptidyl-prolyl cis-trans isomerase activity
I633_RS12670	COG1720	tRNA m6t6A37 methyltransferase activity
I633_RS12680	COG1234	tRNA 3'-trailer cleavage
I633_RS12690	COG0123	including yeast histone deacetylase and acetoin utilization protein
I633_RS12705	COG0516	GMP reductase activity
I633_RS12705	COG0517	IMP dehydrogenase activity
I633_RS12710	COG1570	exodeoxyribonuclease VII activity
I633_RS12730	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I633_RS12735	COG2976	Protein conserved in bacteria
I633_RS12760	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I633_RS12770	COG2166	iron-sulfur cluster assembly
I633_RS12790	COG0719	Fe-S assembly protein
I633_RS12795	COG0396	ATPase activity
I633_RS12800	COG0719	Fe-S assembly protein
I633_RS12805	COG1104	cysteine desulfurase activity
I633_RS12815	COG2072	flavoprotein involved in K transport
I633_RS12825	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I633_RS12830	COG0483	inositol monophosphate 1-phosphatase activity
I633_RS12845	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I633_RS12850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I633_RS12855	COG1862	Preprotein translocase
I633_RS12860	COG0343	queuine tRNA-ribosyltransferase activity
I633_RS12880	COG1842	Phage shock protein A
I633_RS12885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I633_RS12935	COG2066	Belongs to the glutaminase family
I633_RS12940	COG1785	Belongs to the alkaline phosphatase family
I633_RS12945	COG0745	RESPONSE REGULATOR receiver
I633_RS13015	COG0438	transferase activity, transferring glycosyl groups
I633_RS13035	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I633_RS13040	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I633_RS13070	COG5002	protein histidine kinase activity
I633_RS13080	COG0438	transferase activity, transferring glycosyl groups
I633_RS13095	COG0367	asparagine synthase
I633_RS13110	COG2244	polysaccharide biosynthetic process
I633_RS13115	COG1216	Glycosyl transferase, family 2
I633_RS13125	COG0463	Glycosyl transferase, family 2
I633_RS13175	COG0489	protein tyrosine kinase activity
I633_RS13185	COG3267	Type II secretory pathway component ExeA
I633_RS13185	COG3409	Peptidoglycan-binding domain 1 protein
I633_RS13220	COG1560	Kdo2-lipid A biosynthetic process
I633_RS13250	COG3300	MHYT domain
I633_RS13250	COG5001	Diguanylate cyclase
I633_RS13255	COG1435	thymidine kinase activity
I633_RS13265	COG1609	Transcriptional regulator
I633_RS13270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I633_RS13310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I633_RS13350	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I633_RS13400	COG0745	RESPONSE REGULATOR receiver
I633_RS13405	COG2205	protein histidine kinase activity
I633_RS13445	COG2080	2 iron, 2 sulfur cluster binding
I633_RS13455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I633_RS13475	COG1028	Short-chain dehydrogenase reductase Sdr
I633_RS13485	COG0693	protein deglycase activity
I633_RS13490	COG1295	ribonuclease BN
I633_RS13530	COG2814	Major facilitator Superfamily
I633_RS13545	COG0514	ATP-dependent DNA helicase (RecQ)
I633_RS13580	COG4251	negative regulation of phosphorylation
I633_RS13585	COG2133	pyrroloquinoline quinone binding
I633_RS13590	COG3550	peptidyl-serine autophosphorylation
I633_RS13740	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I633_RS13745	COG2971	BadF BadG BcrA BcrD
I633_RS13750	COG0583	DNA-binding transcription factor activity
I633_RS13775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I633_RS13780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I633_RS13785	COG0006	proline dipeptidase activity
I633_RS13800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I633_RS13815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I633_RS13820	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I633_RS13825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I633_RS13845	COG3313	Fe-S protein
I633_RS13880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I633_RS13885	COG0508	dehydrogenase complex catalyzes the overall conversion of
I633_RS13890	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I633_RS13905	COG3023	N-Acetylmuramoyl-L-alanine amidase
I633_RS13910	COG3577	Aspartyl protease
I633_RS13915	COG0157	Belongs to the NadC ModD family
I633_RS13930	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I633_RS13935	COG0237	dephospho-CoA kinase activity
I633_RS13945	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I633_RS13955	COG0494	nUDIX hydrolase
I633_RS13965	COG0739	heme binding
I633_RS13970	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I633_RS13975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I633_RS13980	COG0849	cell division
I633_RS13985	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I633_RS13990	COG1181	Belongs to the D-alanine--D-alanine ligase family
I633_RS13995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I633_RS14010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I633_RS14020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I633_RS14025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I633_RS14030	COG0768	penicillin binding
I633_RS14035	COG3116	cell division
I633_RS14045	COG2001	Belongs to the MraZ family
I633_RS14065	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I633_RS14070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_RS14090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I633_RS14090	COG0678	peroxiredoxin activity
I633_RS14115	COG2204	response regulator
I633_RS14120	COG0784	Response regulator, receiver
I633_RS14120	COG2205	protein histidine kinase activity
I633_RS14145	COG0668	transmembrane transport
I633_RS14150	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I633_RS14155	COG0189	ligase activity
I633_RS14160	COG1678	Uncharacterized ACR, COG1678
I633_RS14165	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I633_RS14190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I633_RS14205	COG0446	pyridine nucleotide-disulphide oxidoreductase
I633_RS14205	COG1902	pentaerythritol trinitrate reductase activity
I633_RS14220	COG0625	glutathione transferase activity
I633_RS14245	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I633_RS14255	COG2814	Major facilitator Superfamily
I633_RS14260	COG0724	RNA recognition motif
I633_RS14290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I633_RS14295	COG0083	homoserine kinase activity
I633_RS14310	COG0583	DNA-binding transcription factor activity
I633_RS14325	COG0640	Transcriptional regulator
I633_RS14335	COG0431	NADPH-dependent FMN reductase
I633_RS14340	COG0798	PFAM Bile acid sodium symporter
I633_RS14345	COG2201	protein-glutamate methylesterase activity
I633_RS14350	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I633_RS14360	COG5002	protein histidine kinase activity
I633_RS14360	COG3850	Histidine kinase
I633_RS14405	COG1748	Saccharopine dehydrogenase
I633_RS14420	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I633_RS14425	COG3107	peptidoglycan biosynthetic process
I633_RS14435	COG0438	transferase activity, transferring glycosyl groups
I633_RS14445	COG2823	Periplasmic or secreted lipoprotein
I633_RS14470	COG2197	response regulator
I633_RS14485	COG4771	TonB-dependent receptor
I633_RS14495	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I633_RS14500	COG0372	Belongs to the citrate synthase family
I633_RS14505	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I633_RS14540	COG3023	N-Acetylmuramoyl-L-alanine amidase
I633_RS14550	COG0493	'glutamate synthase
I633_RS14565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I633_RS14570	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I633_RS14575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I633_RS14580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I633_RS14595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I633_RS14605	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I633_RS14610	COG4942	peptidase
I633_RS14630	COG1902	pentaerythritol trinitrate reductase activity
I633_RS14650	COG0625	glutathione transferase activity
I633_RS14675	COG2894	cell division
I633_RS14680	COG0850	regulation of cytokinetic process
I633_RS14690	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I633_RS14705	COG1981	membrane
I633_RS14735	COG1217	gtp-binding protein TYPA
I633_RS14740	COG0174	glutamine synthetase
I633_RS14750	COG3852	Histidine kinase
I633_RS14760	COG3437	response regulator, receiver
I633_RS14810	COG2927	DNA polymerase III (CHI subunit)
I633_RS14815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I633_RS14825	COG0795	lipopolysaccharide-transporting ATPase activity
I633_RS14930	COG2856	Zn peptidase
I633_RS14990	COG3250	beta-galactosidase activity
I633_RS15020	COG2203	Gaf domain
I633_RS15020	COG2199	diguanylate cyclase activity
I633_RS15045	COG0673	inositol 2-dehydrogenase activity
I633_RS15060	COG0628	permease
I633_RS15075	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I633_RS15080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I633_RS15105	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I633_RS15130	COG4447	cellulose binding
I633_RS15140	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I633_RS15155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I633_RS15165	COG0679	Auxin Efflux Carrier
I633_RS15195	COG1131	(ABC) transporter
I633_RS15205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I633_RS15220	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I633_RS15260	COG2205	protein histidine kinase activity
I633_RS15290	COG2197	response regulator
I633_RS15320	COG0277	FAD linked oxidase domain protein
I633_RS15330	COG1462	curli production assembly transport component CsgG
I633_RS15360	COG2197	response regulator
I633_RS15390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I633_RS15405	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I633_RS15405	COG3264	Mechanosensitive ion channel
I633_RS15445	COG0730	response to heat
I633_RS15475	COG0417	DNA replication proofreading
I633_RS15485	COG0318	PFAM AMP-dependent synthetase and ligase
I633_RS15520	COG1309	transcriptional regulator
I633_RS15530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I633_RS15540	COG1573	uracil-dna glycosylase
I633_RS15545	COG3300	MHYT domain
I633_RS15545	COG5001	Diguanylate cyclase
I633_RS15565	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I633_RS15585	COG1983	PspC domain protein
I633_RS15590	COG1842	Phage shock protein A
I633_RS15600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I633_RS15625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I633_RS15635	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I633_RS15640	COG0204	Acyl-transferase
I633_RS15645	COG0204	Acyl-transferase
I633_RS15650	COG0668	transmembrane transport
I633_RS15665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I633_RS15685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I633_RS15710	COG0848	biopolymer transport protein
I633_RS15730	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I633_RS15760	COG0702	epimerase
I633_RS15775	COG5002	protein histidine kinase activity
I633_RS15775	COG5001	Diguanylate cyclase
I633_RS15785	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I633_RS15795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I633_RS15810	COG0121	glutamine amidotransferase
I633_RS15815	COG4682	membrane
I633_RS15835	COG1953	Uracil, thiamine, allantoin
I633_RS15840	COG4771	TonB-dependent receptor
I633_RS15850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I633_RS15860	COG0596	Alpha beta hydrolase
I633_RS15865	COG0251	oxidation-reduction process
I633_RS15895	COG4628	conserved protein (DUF2132)
I633_RS15900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I633_RS15920	COG1477	protein flavinylation
I633_RS15925	COG2871	sodium ion transport
I633_RS15930	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I633_RS15935	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I633_RS15940	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I633_RS15945	COG1805	sodium ion transport
I633_RS15950	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I633_RS15975	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I633_RS15980	COG0545	Peptidyl-prolyl cis-trans isomerase
I633_RS15985	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I633_RS16000	COG0039	L-malate dehydrogenase activity
I633_RS16005	COG1438	arginine binding
I633_RS16030	COG0572	uridine kinase
I633_RS16035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I633_RS16060	COG2176	DNA-directed DNA polymerase activity
I633_RS16085	COG0189	ligase activity
I633_RS16095	COG4067	protein conserved in archaea
I633_RS16095	COG0189	ligase activity
I633_RS16110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I633_RS16120	COG1283	sodium-dependent phosphate transmembrane transporter activity
I633_RS16125	COG0667	Aldo Keto reductase
I633_RS16140	COG5001	Diguanylate cyclase
I633_RS16175	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I633_RS16185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I633_RS16235	COG2274	protein secretion by the type I secretion system
I633_RS16240	COG0583	DNA-binding transcription factor activity
I633_RS16335	COG1051	belongs to the nudix hydrolase family
I633_RS16340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I633_RS16365	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I633_RS16380	COG0438	transferase activity, transferring glycosyl groups
I633_RS16410	COG0662	Cupin 2, conserved barrel domain protein
I633_RS16410	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I633_RS16430	COG2161	toxin-antitoxin pair type II binding
I633_RS16440	COG0202	RNA polymerase activity
I633_RS16485	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I633_RS16520	COG0784	Response regulator, receiver
I633_RS16520	COG5002	protein histidine kinase activity
I633_RS16575	COG4771	TonB-dependent receptor
I633_RS16590	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I633_RS16645	COG1294	oxidase, subunit
I633_RS16650	COG1522	sequence-specific DNA binding
I633_RS16660	COG1278	Cold shock
I633_RS16685	COG0339	signal peptide processing
I633_RS16690	COG2201	protein-glutamate methylesterase activity
I633_RS16700	COG3852	Histidine kinase
I633_RS16710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I633_RS16715	COG0243	molybdopterin cofactor binding
I633_RS16720	COG4946	Tricorn protease homolog
I633_RS16720	COG1506	peptidase
I633_RS16720	COG0823	Involved in the tonB-independent uptake of proteins
I633_RS16775	COG2197	response regulator
I633_RS16805	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I633_RS16810	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I633_RS16815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I633_RS16830	COG0281	malic enzyme
I633_RS16840	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I633_RS16870	COG0456	acetyltransferase
I633_RS16880	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I633_RS16885	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I633_RS16890	COG2177	Part of the ABC transporter FtsEX involved in
I633_RS16900	COG0552	protein localization to endoplasmic reticulum
I633_RS16905	COG0742	ribosomal rna small subunit methyltransferase
I633_RS16915	COG2095	MarC family integral membrane protein
I633_RS16935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I633_RS16940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I633_RS16945	COG0617	tRNA 3'-terminal CCA addition
I633_RS16950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I633_RS16965	COG0076	glutamate decarboxylase activity
I633_RS16980	COG0842	Transport permease protein
I633_RS16990	COG0745	RESPONSE REGULATOR receiver
I633_RS17000	COG4774	siderophore transport
I633_RS17030	COG1966	Carbon starvation protein
I633_RS17040	COG0657	acetylesterase activity
I633_RS17055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I633_RS17060	COG0049	tRNA binding
I633_RS17065	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I633_RS17070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I633_RS17080	COG0222	ribosome binding
I633_RS17085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I633_RS17090	COG0081	regulation of translation
I633_RS17095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I633_RS17115	COG0250	Participates in transcription elongation, termination and antitermination
I633_RS17120	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I633_RS17135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I633_RS17150	COG0513	Belongs to the DEAD box helicase family
I633_RS17155	COG0418	dihydroorotase activity
I633_RS17160	COG3040	lipid binding
I633_RS17165	COG4989	oxidoreductase activity
I633_RS17170	COG0346	lactoylglutathione lyase activity
I633_RS17175	COG0668	transmembrane transport
I633_RS17195	COG0302	gtp cyclohydrolase
I633_RS17210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I633_RS17230	COG1793	dna ligase
I633_RS17235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I633_RS17240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I633_RS17250	COG1410	methionine synthase
I633_RS17250	COG0646	methionine synthase
I633_RS17255	COG0625	glutathione transferase activity
I633_RS17270	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I633_RS17285	COG1012	belongs to the aldehyde dehydrogenase family
I633_RS17290	COG0028	Belongs to the TPP enzyme family
I633_RS17300	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I633_RS17310	COG0330	HflC and HflK could
I633_RS17315	COG0330	HflC and HflK could
I633_RS17320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I633_RS17325	COG1923	regulation of RNA biosynthetic process
I633_RS17330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I633_RS17345	COG0802	atpase or kinase
I633_RS17355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I633_RS17375	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I633_RS17380	COG0735	belongs to the Fur family
I633_RS17400	COG0305	Participates in initiation and elongation during chromosome replication
I633_RS17425	COG2258	MOSC domain
I633_RS17455	COG2198	Histidine kinase
I633_RS17455	COG2205	protein histidine kinase activity
I633_RS17455	COG0784	Response regulator, receiver
I633_RS17465	COG0577	efflux transmembrane transporter activity
I633_RS17465	COG1136	(ABC) transporter
I633_RS17475	COG0840	transmembrane signaling receptor activity
I633_RS17480	COG5002	protein histidine kinase activity
I633_RS17485	COG0840	transmembrane signaling receptor activity
I633_RS17525	COG2723	6-phospho-beta-galactosidase activity
I633_RS17530	COG1609	Transcriptional regulator
I633_RS17535	COG0477	Major facilitator Superfamily
I633_RS17535	COG2814	Major facilitator Superfamily
I633_RS17540	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I633_RS17550	COG4890	Cyd operon protein YbgT
I633_RS17555	COG1294	oxidase, subunit
I633_RS17590	COG4319	ketosteroid isomerase
I633_RS17615	COG2375	cellular response to nickel ion
I633_RS17620	COG3237	CsbD-like
I633_RS17645	COG0508	dehydrogenase complex catalyzes the overall conversion of
I633_RS17645	COG0596	Alpha beta hydrolase
I633_RS17665	COG3038	cytochrome b561
I633_RS17675	COG1252	NADH dehydrogenase
I633_RS17690	COG0583	DNA-binding transcription factor activity
I633_RS17700	COG2130	NADP-dependent
I633_RS17705	COG5001	Diguanylate cyclase
I633_RS17705	COG4251	negative regulation of phosphorylation
I633_RS17705	COG3706	GGDEF domain
I633_RS17705	COG2203	Gaf domain
I633_RS17710	COG0784	Response regulator, receiver
I633_RS17710	COG2205	protein histidine kinase activity
I633_RS17725	COG4372	Transposase
I633_RS17745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I633_RS17750	COG2181	nitrate reductase activity
I633_RS17755	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I633_RS17760	COG1140	nitrate reductase beta subunit
I633_RS17765	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I633_RS17790	COG2197	response regulator
I633_RS17800	COG2832	Protein of unknown function (DUF454)
I633_RS17810	COG0314	molybdopterin synthase activity
I633_RS17815	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I633_RS17820	COG0315	cyclic pyranopterin monophosphate synthase activity
I633_RS17825	COG0521	Mo-molybdopterin cofactor biosynthetic process
I633_RS17830	COG0746	molybdenum cofactor guanylyltransferase activity
I633_RS17835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I633_RS17850	COG3154	lipid carrier protein
I633_RS17860	COG0826	peptidase U32
I633_RS17865	COG0826	peptidase U32
I633_RS17880	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I633_RS17905	COG2223	nitrite transmembrane transporter activity
I633_RS17910	COG0515	serine threonine protein kinase
I633_RS17945	COG1349	DNA-binding transcription factor activity
I633_RS17950	COG0673	inositol 2-dehydrogenase activity
I633_RS17965	COG0697	spore germination
I633_RS17970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I633_RS17980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I633_RS17985	COG1166	arginine decarboxylase activity
I633_RS17995	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I633_RS18055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I633_RS18065	COG0109	protoheme IX farnesyltransferase activity
I633_RS18085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I633_RS18135	COG4232	protein-disulfide reductase activity
I633_RS18140	COG0739	heme binding
I633_RS18145	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I633_RS18220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I633_RS18225	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I633_RS18240	COG0151	Belongs to the GarS family
I633_RS18260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I633_RS18265	COG3954	Phosphoribulokinase
I633_RS18290	COG1501	Belongs to the glycosyl hydrolase 31 family
I633_RS18320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I633_RS18325	COG1459	type II secretion system
I633_RS18330	COG2165	general secretion pathway protein
I633_RS18335	COG2165	general secretion pathway protein
I633_RS18340	COG2165	general secretion pathway protein
I633_RS18345	COG4795	General secretion pathway protein
I633_RS18375	COG3344	reverse transcriptase
I633_RS18385	COG4667	esterase of the alpha-beta hydrolase superfamily
I633_RS18395	COG1012	belongs to the aldehyde dehydrogenase family
I633_RS18405	COG1011	Hydrolase
I633_RS18415	COG1218	3'(2'),5'-bisphosphate nucleotidase
I633_RS18425	COG2943	transferase activity, transferring hexosyl groups
I633_RS18430	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I633_RS18440	COG3089	Belongs to the UPF0270 family
I633_RS18445	COG0429	hydrolase of the alpha beta-hydrolase fold
I633_RS18470	COG2900	Belongs to the SlyX family
I633_RS18480	COG0545	Peptidyl-prolyl cis-trans isomerase
I633_RS18490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I633_RS18495	COG2183	response to ionizing radiation
I633_RS18520	COG1609	Transcriptional regulator
I633_RS18520	COG2207	Transcriptional regulator
I633_RS18525	COG2211	Major facilitator Superfamily
I633_RS18545	COG0667	Aldo Keto reductase
I633_RS18550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I633_RS18555	COG2115	Belongs to the xylose isomerase family
I633_RS18560	COG1070	Carbohydrate kinase
I633_RS18580	COG0477	Major facilitator Superfamily
I633_RS18625	COG0596	Alpha beta hydrolase
I633_RS18630	COG1040	competence protein
I633_RS18650	COG1794	racemase activity, acting on amino acids and derivatives
I633_RS18665	COG0726	polysaccharide deacetylase
I633_RS18665	COG1649	PFAM Uncharacterised BCR, COG1649
I633_RS18675	COG1999	signal sequence binding
I633_RS18680	COG0109	protoheme IX farnesyltransferase activity
I633_RS18685	COG1612	heme a metabolic process
I633_RS18715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I633_RS18720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I633_RS18740	COG0129	dihydroxy-acid dehydratase activity
I633_RS18750	COG0606	chelatase, subunit chli
I633_RS18805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I633_RS18835	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I633_RS18885	COG0425	Belongs to the sulfur carrier protein TusA family
I633_RS18900	COG1561	YicC-like family, N-terminal region
I633_RS18955	COG3645	SOS response
I633_RS19035	COG2723	6-phospho-beta-galactosidase activity
I633_RS19040	COG2211	Major facilitator Superfamily
I633_RS19045	COG1609	Transcriptional regulator
I633_RS19060	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I633_RS19060	COG2199	diguanylate cyclase activity
I633_RS19085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I633_RS19105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I633_RS19110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I633_RS19130	COG1475	DNA binding
I633_RS19135	COG1192	Involved in chromosome partitioning
I633_RS19160	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I633_RS19175	COG0706	membrane insertase activity
I633_RS19180	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I633_RS19185	COG0594	ribonuclease P activity
I633_RS19190	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I633_RS19265	COG0596	Alpha beta hydrolase
I633_RS19445	COG4191	Histidine kinase
I633_RS19450	COG2203	Gaf domain
I633_RS19450	COG3706	GGDEF domain
I633_RS19450	COG4251	negative regulation of phosphorylation
I633_RS19450	COG5001	Diguanylate cyclase
I633_RS19455	COG2826	transposase and inactivated derivatives, IS30 family
I633_RS19475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I633_RS19535	COG1988	membrane-bound metal-dependent
I633_RS19570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I633_RS19700	COG0633	Ferredoxin
I633_RS19760	COG4974	Belongs to the 'phage' integrase family
I633_RS19765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I633_RS19770	COG1061	Type III restriction enzyme res subunit
I633_RS19795	COG1061	Type III restriction enzyme res subunit
I633_RS19800	COG1002	Type II restriction enzyme, methylase subunits
I633_RS19835	COG2201	protein-glutamate methylesterase activity
I633_RS19840	COG1002	Type II restriction enzyme, methylase subunits
I633_RS19850	COG3152	Membrane
I633_RS19890	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I633_RS20015	COG0629	single-stranded DNA binding
I633_RS20045	COG5654	RES domain protein
I633_RS20190	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I633_RS20250	COG3135	benzoate transporter