locus-tag	class	description
BM524_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BM524_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BM524_RS00020	COG0187	DNA topoisomerase II activity
BM524_RS00050	COG2818	Glycosylase
BM524_RS00060	COG3078	GTPase activator activity
BM524_RS00080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM524_RS00080	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM524_RS00085	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BM524_RS00090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BM524_RS00095	COG0569	domain protein
BM524_RS00100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BM524_RS00100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BM524_RS00105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BM524_RS00120	COG0758	DNA mediated transformation
BM524_RS00135	COG0009	L-threonylcarbamoyladenylate synthase
BM524_RS00140	COG0408	coproporphyrinogen oxidase activity
BM524_RS00145	COG3047	cAMP biosynthetic process
BM524_RS00160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BM524_RS00230	COG2234	aminopeptidase activity
BM524_RS00235	COG3562	capsule polysaccharide
BM524_RS00245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BM524_RS00270	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM524_RS00300	COG3642	lipopolysaccharide core region biosynthetic process
BM524_RS00305	COG0859	PFAM glycosyl transferase family 9
BM524_RS00335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM524_RS00350	COG3161	chorismate lyase activity
BM524_RS00355	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BM524_RS00375	COG0210	DNA helicase
BM524_RS00395	COG4771	TonB-dependent receptor
BM524_RS00400	COG0583	DNA-binding transcription factor activity
BM524_RS00420	COG0667	Aldo Keto reductase
BM524_RS00445	COG2159	amidohydrolase
BM524_RS00455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BM524_RS00475	COG1757	Na H antiporter
BM524_RS00490	COG1959	2 iron, 2 sulfur cluster binding
BM524_RS00495	COG0730	response to heat
BM524_RS00525	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BM524_RS00530	COG4988	ABC transporter
BM524_RS00540	COG1271	oxidase subunit
BM524_RS00545	COG0425	Belongs to the sulfur carrier protein TusA family
BM524_RS00545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM524_RS00555	COG0450	alkyl hydroperoxide reductase
BM524_RS00560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BM524_RS00590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_RS00595	COG0842	Transport permease protein
BM524_RS00595	COG1129	ABC transporter
BM524_RS00600	COG0842	Transport permease protein
BM524_RS00610	COG4771	TonB-dependent receptor
BM524_RS00625	COG0583	DNA-binding transcription factor activity
BM524_RS00635	COG3106	COG3106 Predicted ATPase
BM524_RS00650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BM524_RS00670	COG0352	thiamine-phosphate diphosphorylase activity
BM524_RS00680	COG3071	HemY protein
BM524_RS00685	COG2959	enzyme of heme biosynthesis
BM524_RS00695	COG0181	hydroxymethylbilane synthase activity
BM524_RS00710	COG0194	GDP metabolic process
BM524_RS00720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BM524_RS00730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM524_RS00735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BM524_RS00745	COG0678	peroxiredoxin activity
BM524_RS00760	COG1178	ABC-type Fe3 transport system permease component
BM524_RS00765	COG3842	ATPase activity
BM524_RS00770	COG0668	transmembrane transport
BM524_RS00775	COG2081	HI0933 family
BM524_RS00785	COG2200	EAL domain
BM524_RS00790	COG0583	DNA-binding transcription factor activity
BM524_RS00815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_RS00830	COG0427	acetyl-CoA hydrolase
BM524_RS00835	COG0123	including yeast histone deacetylase and acetoin utilization protein
BM524_RS00850	COG0840	transmembrane signaling receptor activity
BM524_RS00860	COG3064	Membrane
BM524_RS00870	COG5002	protein histidine kinase activity
BM524_RS00870	COG5001	Diguanylate cyclase
BM524_RS00885	COG0514	ATP-dependent DNA helicase (RecQ)
BM524_RS00890	COG2239	Acts as a magnesium transporter
BM524_RS00895	COG2962	Rard protein
BM524_RS00905	COG0210	DNA helicase
BM524_RS00915	COG1011	Hydrolase
BM524_RS00920	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BM524_RS00930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BM524_RS00935	COG0019	diaminopimelate decarboxylase activity
BM524_RS00965	COG0163	prenyltransferase activity
BM524_RS00970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BM524_RS00980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BM524_RS01020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BM524_RS01025	COG2814	Major facilitator Superfamily
BM524_RS01030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM524_RS01060	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BM524_RS01075	COG0629	single-stranded DNA binding
BM524_RS01100	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM524_RS01125	COG1349	DNA-binding transcription factor activity
BM524_RS01170	COG3267	Type II secretory pathway component ExeA
BM524_RS01170	COG3409	Peptidoglycan-binding domain 1 protein
BM524_RS01180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BM524_RS01185	COG1459	type II secretion system
BM524_RS01195	COG2165	general secretion pathway protein
BM524_RS01200	COG2165	general secretion pathway protein
BM524_RS01205	COG2165	general secretion pathway protein
BM524_RS01230	COG1077	Cell shape determining protein MreB Mrl
BM524_RS01235	COG1792	Involved in formation and maintenance of cell shape
BM524_RS01240	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BM524_RS01250	COG1530	ribonuclease E activity
BM524_RS01260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM524_RS01265	COG0312	modulator of DNA gyrase
BM524_RS01270	COG3028	Belongs to the UPF0307 family
BM524_RS01275	COG0312	modulator of DNA gyrase
BM524_RS01290	COG0745	RESPONSE REGULATOR receiver
BM524_RS01295	COG4191	Histidine kinase
BM524_RS01295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM524_RS01300	COG0297	glycogen (starch) synthase activity
BM524_RS01310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BM524_RS01315	COG0596	Alpha beta hydrolase
BM524_RS01355	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BM524_RS01390	COG0745	RESPONSE REGULATOR receiver
BM524_RS01395	COG2198	Histidine kinase
BM524_RS01395	COG0643	Histidine kinase
BM524_RS01400	COG0835	chemotaxis
BM524_RS01415	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BM524_RS01430	COG0745	RESPONSE REGULATOR receiver
BM524_RS01440	COG0835	chemotaxis
BM524_RS01460	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BM524_RS01535	COG0673	inositol 2-dehydrogenase activity
BM524_RS01545	COG2211	Major facilitator Superfamily
BM524_RS01550	COG1082	Xylose isomerase domain protein TIM barrel
BM524_RS01570	COG1454	alcohol dehydrogenase
BM524_RS01625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BM524_RS01645	COG0089	rRNA binding
BM524_RS01655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BM524_RS01665	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BM524_RS01680	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BM524_RS01685	COG0438	transferase activity, transferring glycosyl groups
BM524_RS01695	COG1519	Transferase
BM524_RS01715	COG0840	transmembrane signaling receptor activity
BM524_RS01730	COG0788	formyltetrahydrofolate deformylase activity
BM524_RS01740	COG1643	Atp-dependent helicase
BM524_RS01745	COG2951	lytic endotransglycosylase activity
BM524_RS01750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BM524_RS01760	COG2354	Protein conserved in bacteria
BM524_RS01785	COG0004	ammonium transporteR
BM524_RS01790	COG0405	Gamma-glutamyltransferase
BM524_RS01795	COG2837	iron assimilation
BM524_RS01810	COG0540	Belongs to the ATCase OTCase family
BM524_RS01835	COG5002	protein histidine kinase activity
BM524_RS01835	COG0784	Response regulator, receiver
BM524_RS01835	COG2205	protein histidine kinase activity
BM524_RS01850	COG3300	MHYT domain
BM524_RS01850	COG5001	Diguanylate cyclase
BM524_RS01860	COG1012	belongs to the aldehyde dehydrogenase family
BM524_RS01870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BM524_RS01885	COG0180	Tryptophanyl-tRNA synthetase
BM524_RS01890	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BM524_RS01910	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BM524_RS01920	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BM524_RS01955	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BM524_RS01960	COG0281	malic enzyme
BM524_RS01970	COG0625	glutathione transferase activity
BM524_RS01980	COG0753	catalase activity
BM524_RS02005	COG3300	MHYT domain
BM524_RS02005	COG5001	Diguanylate cyclase
BM524_RS02010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BM524_RS02010	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BM524_RS02020	COG0137	argininosuccinate synthase activity
BM524_RS02040	COG1803	Methylglyoxal synthase
BM524_RS02050	COG0745	RESPONSE REGULATOR receiver
BM524_RS02055	COG2205	protein histidine kinase activity
BM524_RS02060	COG2267	carboxylic ester hydrolase activity
BM524_RS02065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BM524_RS02075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BM524_RS02085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BM524_RS02090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM524_RS02095	COG4942	peptidase
BM524_RS02100	COG2861	carbohydrate metabolic process
BM524_RS02125	COG1162	GTPase activity
BM524_RS02130	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BM524_RS02150	COG4771	TonB-dependent receptor
BM524_RS02155	COG0457	Tetratricopeptide repeat
BM524_RS02170	COG0028	Belongs to the TPP enzyme family
BM524_RS02190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BM524_RS02195	COG0805	protein transport
BM524_RS02205	COG0084	hydrolase, TatD family'
BM524_RS02210	COG5001	Diguanylate cyclase
BM524_RS02210	COG4251	negative regulation of phosphorylation
BM524_RS02210	COG3706	GGDEF domain
BM524_RS02210	COG2203	Gaf domain
BM524_RS02220	COG0248	Ppx GppA phosphatase
BM524_RS02225	COG0513	Belongs to the DEAD box helicase family
BM524_RS02230	COG3118	belongs to the thioredoxin family
BM524_RS02235	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BM524_RS02240	COG1473	amidohydrolase
BM524_RS02245	COG5002	protein histidine kinase activity
BM524_RS02245	COG0784	Response regulator, receiver
BM524_RS02250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BM524_RS02255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BM524_RS02260	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BM524_RS02275	COG0783	Belongs to the Dps family
BM524_RS02280	COG2133	pyrroloquinoline quinone binding
BM524_RS02285	COG0823	Involved in the tonB-independent uptake of proteins
BM524_RS02285	COG1506	peptidase
BM524_RS02285	COG4946	Tricorn protease homolog
BM524_RS02295	COG3118	belongs to the thioredoxin family
BM524_RS02310	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
BM524_RS02320	COG1012	belongs to the aldehyde dehydrogenase family
BM524_RS02345	COG1757	Na H antiporter
BM524_RS02360	COG3876	Protein conserved in bacteria
BM524_RS02365	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BM524_RS02375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BM524_RS02385	COG0346	lactoylglutathione lyase activity
BM524_RS02410	COG2824	Alkylphosphonate utilization operon protein PhnA
BM524_RS02415	COG0454	-acetyltransferase
BM524_RS02450	COG0183	Belongs to the thiolase family
BM524_RS02455	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM524_RS02455	COG1024	Enoyl-CoA hydratase
BM524_RS02465	COG0006	proline dipeptidase activity
BM524_RS02475	COG0142	geranyltranstransferase activity
BM524_RS02505	COG4942	peptidase
BM524_RS02505	COG1388	LysM domain
BM524_RS02510	COG1238	metal cluster binding
BM524_RS02520	COG0585	pseudouridine synthase activity
BM524_RS02525	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BM524_RS02535	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BM524_RS02545	COG0840	transmembrane signaling receptor activity
BM524_RS02585	COG0494	nUDIX hydrolase
BM524_RS02590	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
BM524_RS02595	COG0730	response to heat
BM524_RS02600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BM524_RS02605	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BM524_RS02640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BM524_RS02650	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BM524_RS02660	COG1648	precorrin-2 dehydrogenase activity
BM524_RS02660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BM524_RS02665	COG0513	Belongs to the DEAD box helicase family
BM524_RS02680	COG1538	Outer membrane efflux protein
BM524_RS02685	COG0494	nUDIX hydrolase
BM524_RS02695	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BM524_RS02700	COG3150	esterase
BM524_RS02705	COG0187	DNA topoisomerase II activity
BM524_RS02715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM524_RS02740	COG1509	lysine 2,3-aminomutase activity
BM524_RS02745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BM524_RS02750	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BM524_RS02765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BM524_RS02770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM524_RS02785	COG0271	Belongs to the BolA IbaG family
BM524_RS02790	COG0671	phosphoesterase, PA-phosphatase related
BM524_RS02800	COG3707	response regulator
BM524_RS02815	COG0659	secondary active sulfate transmembrane transporter activity
BM524_RS02825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BM524_RS02835	COG0243	molybdopterin cofactor binding
BM524_RS02840	COG1648	precorrin-2 dehydrogenase activity
BM524_RS02840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BM524_RS02845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BM524_RS02855	COG1116	anion transmembrane transporter activity
BM524_RS02855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BM524_RS02865	COG1116	anion transmembrane transporter activity
BM524_RS02880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BM524_RS02885	COG4206	TonB-dependent receptor
BM524_RS02890	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BM524_RS02895	COG0348	domain, Protein
BM524_RS02910	COG1960	acyl-CoA dehydrogenase activity
BM524_RS02915	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_RS02925	COG4948	Mandelate Racemase Muconate Lactonizing
BM524_RS02940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_RS02945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM524_RS02970	COG0358	DNA primase activity
BM524_RS02975	COG1610	YqeY-like protein
BM524_RS02995	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BM524_RS03000	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BM524_RS03015	COG0537	adenosine 5'-monophosphoramidase activity
BM524_RS03030	COG3135	benzoate transporter
BM524_RS03035	COG1396	sequence-specific DNA binding
BM524_RS03040	COG2974	May be involved in recombination
BM524_RS03045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM524_RS03045	COG4191	Histidine kinase
BM524_RS03050	COG0745	RESPONSE REGULATOR receiver
BM524_RS03055	COG5002	protein histidine kinase activity
BM524_RS03080	COG0811	peptide transport
BM524_RS03085	COG0811	peptide transport
BM524_RS03090	COG0848	biopolymer transport protein
BM524_RS03095	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BM524_RS03105	COG3437	response regulator, receiver
BM524_RS03125	COG2133	pyrroloquinoline quinone binding
BM524_RS03135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BM524_RS03165	COG0527	aspartate kinase activity
BM524_RS03175	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BM524_RS03180	COG2967	ApaG domain
BM524_RS03190	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BM524_RS03195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM524_RS03200	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BM524_RS03205	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BM524_RS03215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BM524_RS03235	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BM524_RS03250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BM524_RS03255	COG3956	TIGRFAM MazG family protein
BM524_RS03280	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BM524_RS03285	COG0723	plastoquinol--plastocyanin reductase activity
BM524_RS03290	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BM524_RS03295	COG2857	Cytochrome c1
BM524_RS03300	COG0625	glutathione transferase activity
BM524_RS03305	COG2969	positive regulation of protein catabolic process
BM524_RS03320	COG0745	RESPONSE REGULATOR receiver
BM524_RS03325	COG2239	Acts as a magnesium transporter
BM524_RS03330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BM524_RS03350	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BM524_RS03355	COG1137	ATPase activity
BM524_RS03360	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BM524_RS03370	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BM524_RS03385	COG1127	ABC transporter
BM524_RS03390	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BM524_RS03395	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BM524_RS03400	COG2854	intermembrane phospholipid transfer
BM524_RS03410	COG5007	Belongs to the BolA IbaG family
BM524_RS03420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM524_RS03425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM524_RS03435	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BM524_RS03470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM524_RS03485	COG4771	TonB-dependent receptor
BM524_RS03490	COG0697	spore germination
BM524_RS03495	COG0784	Response regulator, receiver
BM524_RS03495	COG2205	protein histidine kinase activity
BM524_RS03520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BM524_RS03530	COG0126	phosphoglycerate kinase activity
BM524_RS03535	COG3588	fructose-bisphosphate aldolase
BM524_RS03545	COG4946	Tricorn protease homolog
BM524_RS03545	COG1506	peptidase
BM524_RS03545	COG0823	Involved in the tonB-independent uptake of proteins
BM524_RS03550	COG0248	Ppx GppA phosphatase
BM524_RS03555	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BM524_RS03565	COG0573	inorganic phosphate transmembrane transporter activity
BM524_RS03575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BM524_RS03585	COG0306	phosphate transporter
BM524_RS03595	COG0583	DNA-binding transcription factor activity
BM524_RS03605	COG1272	protein, Hemolysin III
BM524_RS03610	COG1846	Transcriptional regulator
BM524_RS03615	COG1764	response to oxidative stress
BM524_RS03630	COG1739	Uncharacterized protein family UPF0029
BM524_RS03640	COG0583	DNA-binding transcription factor activity
BM524_RS03645	COG4989	oxidoreductase activity
BM524_RS03660	COG0420	3'-5' exonuclease activity
BM524_RS03665	COG0419	ATPase involved in DNA repair
BM524_RS03675	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BM524_RS03700	COG2188	Transcriptional regulator
BM524_RS03710	COG2986	histidine ammonia-lyase
BM524_RS03735	COG0488	(ABC) transporter
BM524_RS03760	COG0668	transmembrane transport
BM524_RS03775	COG0582	viral genome integration into host DNA
BM524_RS03780	COG4249	Peptidase C14 caspase catalytic subunit p20
BM524_RS03780	COG2319	Wd-40 repeat
BM524_RS03820	COG1518	maintenance of DNA repeat elements
BM524_RS03825	COG1203	CRISPR-associated helicase, Cas3
BM524_RS03875	COG1346	cytolysis
BM524_RS03905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BM524_RS03915	COG0513	Belongs to the DEAD box helicase family
BM524_RS03925	COG3267	Type II secretory pathway component ExeA
BM524_RS03925	COG3409	Peptidoglycan-binding domain 1 protein
BM524_RS03940	COG0066	3-isopropylmalate dehydratase activity
BM524_RS03950	COG0473	3-isopropylmalate dehydrogenase activity
BM524_RS03955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BM524_RS03980	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BM524_RS03995	COG4555	ABC transporter
BM524_RS04000	COG1668	transmembrane transport
BM524_RS04010	COG0745	RESPONSE REGULATOR receiver
BM524_RS04040	COG4133	protoheme IX ABC transporter activity
BM524_RS04045	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM524_RS04050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM524_RS04055	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM524_RS04065	COG1138	Cytochrome C-type biogenesis protein
BM524_RS04070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BM524_RS04085	COG2853	Lipoprotein
BM524_RS04090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BM524_RS04110	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BM524_RS04115	COG1596	polysaccharide export
BM524_RS04115	COG1555	photosystem II stabilization
BM524_RS04120	COG0473	3-isopropylmalate dehydrogenase activity
BM524_RS04135	COG1611	Belongs to the LOG family
BM524_RS04145	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM524_RS04145	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM524_RS04200	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BM524_RS04205	COG0024	Methionine aminopeptidase
BM524_RS04210	COG0052	Belongs to the universal ribosomal protein uS2 family
BM524_RS04220	COG0528	UMP kinase activity
BM524_RS04235	COG0575	Belongs to the CDS family
BM524_RS04260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BM524_RS04280	COG0587	DNA-directed DNA polymerase activity
BM524_RS04285	COG0825	malonyl-CoA metabolic process
BM524_RS04290	COG0037	tRNA processing
BM524_RS04320	COG0047	phosphoribosylformylglycinamidine synthase activity
BM524_RS04320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BM524_RS04325	COG2840	Smr protein MutS2
BM524_RS04345	COG3047	cAMP biosynthetic process
BM524_RS04345	COG2885	chlorophyll binding
BM524_RS04355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_RS04360	COG2197	response regulator
BM524_RS04400	COG0835	chemotaxis
BM524_RS04400	COG0784	Response regulator, receiver
BM524_RS04405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BM524_RS04410	COG1815	bacterial-type flagellum-dependent cell motility
BM524_RS04430	COG4787	bacterial-type flagellum-dependent cell motility
BM524_RS04450	COG3951	Flagellar rod assembly protein muramidase FlgJ
BM524_RS04450	COG1705	Flagellar rod assembly protein muramidase FlgJ
BM524_RS04455	COG1256	bacterial-type flagellum assembly
BM524_RS04480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BM524_RS04485	COG1334	flagellar protein FlaG
BM524_RS04490	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BM524_RS04540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BM524_RS04545	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BM524_RS04545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM524_RS04555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM524_RS04565	COG1442	glycosyl transferase family 8
BM524_RS04575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BM524_RS04580	COG1086	Polysaccharide biosynthesis protein
BM524_RS04595	COG3475	LICD family
BM524_RS04600	COG2089	acid synthase
BM524_RS04610	COG1083	cytidylyl-transferase
BM524_RS04620	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BM524_RS04645	COG1677	Flagellar hook-basal body complex protein FliE
BM524_RS04650	COG1766	The M ring may be actively involved in energy transduction
BM524_RS04655	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BM524_RS04705	COG1987	bacterial-type flagellum assembly
BM524_RS04720	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BM524_RS04745	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BM524_RS04750	COG0643	Histidine kinase
BM524_RS04750	COG0784	Response regulator, receiver
BM524_RS04750	COG2198	Histidine kinase
BM524_RS04760	COG1192	Involved in chromosome partitioning
BM524_RS04770	COG0835	chemotaxis
BM524_RS04785	COG1410	methionine synthase
BM524_RS04785	COG0646	methionine synthase
BM524_RS04790	COG1410	methionine synthase
BM524_RS04790	COG0646	methionine synthase
BM524_RS04800	COG3123	guanosine phosphorylase activity
BM524_RS04810	COG0583	DNA-binding transcription factor activity
BM524_RS04815	COG0583	DNA-binding transcription factor activity
BM524_RS04825	COG0659	secondary active sulfate transmembrane transporter activity
BM524_RS04840	COG3590	peptidase
BM524_RS04850	COG2137	regulation of response to DNA damage stimulus
BM524_RS04855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BM524_RS04885	COG0511	ligase activity, forming carbon-carbon bonds
BM524_RS04885	COG5016	pyruvate
BM524_RS04890	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BM524_RS04895	COG4172	Belongs to the ABC transporter superfamily
BM524_RS04905	COG4171	peptide transport system, permease
BM524_RS04910	COG4168	peptide transport system, permease
BM524_RS04915	COG0747	negative chemotaxis
BM524_RS04920	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BM524_RS04925	COG1842	Phage shock protein A
BM524_RS04955	COG0625	glutathione transferase activity
BM524_RS04960	COG1522	sequence-specific DNA binding
BM524_RS05025	COG0811	peptide transport
BM524_RS05030	COG0811	peptide transport
BM524_RS05035	COG0848	biopolymer transport protein
BM524_RS05050	COG1444	tRNA N-acetyltransferase activity
BM524_RS05090	COG0456	acetyltransferase
BM524_RS05105	COG0583	DNA-binding transcription factor activity
BM524_RS05110	COG2814	Major facilitator Superfamily
BM524_RS05120	COG0656	L-ascorbic acid biosynthetic process
BM524_RS05140	COG1846	Transcriptional regulator
BM524_RS05170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BM524_RS05200	COG0543	2 iron, 2 sulfur cluster binding
BM524_RS05200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BM524_RS05215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BM524_RS05220	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BM524_RS05225	COG0564	pseudouridine synthase activity
BM524_RS05235	COG0612	Peptidase, M16
BM524_RS05240	COG2918	glutathione biosynthetic process
BM524_RS05260	COG2840	Smr protein MutS2
BM524_RS05265	COG2890	protein-(glutamine-N5) methyltransferase activity
BM524_RS05280	COG2719	SpoVR family
BM524_RS05285	COG2718	Belongs to the UPF0229 family
BM524_RS05290	COG2766	serine protein kinase
BM524_RS05295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BM524_RS05300	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BM524_RS05305	COG4771	TonB-dependent receptor
BM524_RS05330	COG0450	alkyl hydroperoxide reductase
BM524_RS05340	COG2885	chlorophyll binding
BM524_RS05345	COG0584	glycerophosphoryl diester phosphodiesterase
BM524_RS05350	COG0346	lactoylglutathione lyase activity
BM524_RS05355	COG1278	Cold shock
BM524_RS05375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BM524_RS05380	COG4660	Part of a membrane complex involved in electron transport
BM524_RS05385	COG4659	FMN binding
BM524_RS05390	COG4658	electron transport chain
BM524_RS05395	COG4656	Part of a membrane complex involved in electron transport
BM524_RS05400	COG2878	Part of a membrane complex involved in electron transport
BM524_RS05405	COG4657	Part of a membrane complex involved in electron transport
BM524_RS05420	COG0534	Mate efflux family protein
BM524_RS05425	COG0556	nucleotide-excision repair
BM524_RS05440	COG0602	queuosine metabolic process
BM524_RS05450	COG0367	asparagine synthase
BM524_RS05475	COG3273	potassium ion transport
BM524_RS05475	COG0471	metal ion transport
BM524_RS05490	COG0529	Catalyzes the synthesis of activated sulfate
BM524_RS05495	COG0175	sulfate reduction
BM524_RS05500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM524_RS05530	COG2304	oxidoreductase activity
BM524_RS05550	COG0714	Associated with various cellular activities
BM524_RS05560	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM524_RS05560	COG1024	Enoyl-CoA hydratase
BM524_RS05575	COG1025	Belongs to the peptidase M16 family
BM524_RS05580	COG2062	phosphohistidine phosphatase, SixA
BM524_RS05590	COG4536	flavin adenine dinucleotide binding
BM524_RS05595	COG4137	Cytochrome C assembly protein
BM524_RS05600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BM524_RS05645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_RS05650	COG1132	(ABC) transporter
BM524_RS05665	COG0228	four-way junction DNA binding
BM524_RS05670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BM524_RS05675	COG0336	Belongs to the RNA methyltransferase TrmD family
BM524_RS05680	COG0335	large ribosomal subunit rRNA binding
BM524_RS05685	COG2860	membrane
BM524_RS05695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BM524_RS05700	COG0287	Prephenate dehydrogenase
BM524_RS05700	COG1605	Chorismate mutase
BM524_RS05705	COG1605	Chorismate mutase
BM524_RS05705	COG0077	Prephenate dehydratase
BM524_RS05710	COG0745	RESPONSE REGULATOR receiver
BM524_RS05715	COG0023	Translation Initiation Factor
BM524_RS05745	COG2205	protein histidine kinase activity
BM524_RS05755	COG2204	response regulator
BM524_RS05760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BM524_RS05775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BM524_RS05780	COG0494	nUDIX hydrolase
BM524_RS05785	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BM524_RS05790	COG0632	four-way junction helicase activity
BM524_RS05795	COG2255	four-way junction helicase activity
BM524_RS05800	COG0824	Thioesterase
BM524_RS05805	COG0811	peptide transport
BM524_RS05820	COG0823	Involved in the tonB-independent uptake of proteins
BM524_RS05825	COG2885	chlorophyll binding
BM524_RS05830	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
BM524_RS05850	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BM524_RS05865	COG4667	esterase of the alpha-beta hydrolase superfamily
BM524_RS05870	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BM524_RS05880	COG0784	Response regulator, receiver
BM524_RS05880	COG2205	protein histidine kinase activity
BM524_RS05895	COG0300	oxidoreductase activity
BM524_RS05900	COG3038	cytochrome b561
BM524_RS05930	COG0583	DNA-binding transcription factor activity
BM524_RS05935	COG1064	alcohol dehydrogenase
BM524_RS05940	COG1451	nucleotide metabolic process
BM524_RS05945	COG0517	IMP dehydrogenase activity
BM524_RS05950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM524_RS05960	COG1309	transcriptional regulator
BM524_RS05965	COG4774	siderophore transport
BM524_RS05985	COG3706	GGDEF domain
BM524_RS05995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BM524_RS05995	COG3008	intermembrane lipid transfer
BM524_RS06000	COG2995	paraquat-inducible protein a
BM524_RS06020	COG2207	Transcriptional regulator
BM524_RS06025	COG0017	Asparaginyl-tRNA synthetase
BM524_RS06040	COG0189	ligase activity
BM524_RS06070	COG0156	8-amino-7-oxononanoate synthase activity
BM524_RS06075	COG2226	methyltransferase
BM524_RS06085	COG3340	Belongs to the peptidase S51 family
BM524_RS06090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BM524_RS06095	COG4139	cobalamin transport
BM524_RS06100	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
BM524_RS06105	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BM524_RS06120	COG5265	(ABC) transporter
BM524_RS06125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BM524_RS06135	COG0745	RESPONSE REGULATOR receiver
BM524_RS06155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM524_RS06195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM524_RS06210	COG2755	lipolytic protein G-D-S-L family
BM524_RS06215	COG4181	ATPase activity
BM524_RS06220	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BM524_RS06225	COG1090	epimerase
BM524_RS06230	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BM524_RS06235	COG0628	permease
BM524_RS06260	COG2350	Protein conserved in bacteria
BM524_RS06265	COG0159	tryptophan synthase activity
BM524_RS06275	COG0135	phosphoribosylanthranilate isomerase activity
BM524_RS06275	COG0134	indole-3-glycerol-phosphate synthase activity
BM524_RS06280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BM524_RS06290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BM524_RS06295	COG0613	PHP domain protein
BM524_RS06300	COG0009	L-threonylcarbamoyladenylate synthase
BM524_RS06310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BM524_RS06320	COG0656	L-ascorbic acid biosynthetic process
BM524_RS06325	COG0110	maltose O-acetyltransferase activity
BM524_RS06335	COG2733	membrane
BM524_RS06355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_RS06360	COG0500	methyltransferase
BM524_RS06365	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM524_RS06370	COG0497	DNA recombination
BM524_RS06375	COG0783	Belongs to the Dps family
BM524_RS06380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BM524_RS06385	COG1454	alcohol dehydrogenase
BM524_RS06390	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_RS06400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BM524_RS06405	COG2610	gluconate transmembrane transporter activity
BM524_RS06425	COG2205	protein histidine kinase activity
BM524_RS06425	COG0784	Response regulator, receiver
BM524_RS06425	COG2198	Histidine kinase
BM524_RS06445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BM524_RS06455	COG0484	heat shock protein binding
BM524_RS06460	COG3909	cytochrome
BM524_RS06480	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BM524_RS06490	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BM524_RS06495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BM524_RS06520	COG0857	belongs to the CobB CobQ family
BM524_RS06520	COG0280	phosphate acetyltransferase
BM524_RS06525	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BM524_RS06530	COG4535	Mg2 and Co2 transporter CorC
BM524_RS06540	COG1702	phosphate starvation-inducible protein PhoH
BM524_RS06550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM524_RS06580	COG1607	acyl-coa hydrolase
BM524_RS06585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BM524_RS06595	COG1115	amino acid carrier protein
BM524_RS06645	COG0012	GTP binding
BM524_RS06660	COG1064	alcohol dehydrogenase
BM524_RS06675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BM524_RS06685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BM524_RS06690	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BM524_RS06695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BM524_RS06705	COG2890	protein-(glutamine-N5) methyltransferase activity
BM524_RS06710	COG3437	response regulator, receiver
BM524_RS06710	COG0784	Response regulator, receiver
BM524_RS06720	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BM524_RS06730	COG0583	DNA-binding transcription factor activity
BM524_RS06740	COG2363	Small membrane protein
BM524_RS06755	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
BM524_RS06760	COG0515	serine threonine protein kinase
BM524_RS06765	COG2116	formate transmembrane transporter activity
BM524_RS06780	COG0714	Associated with various cellular activities
BM524_RS06785	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
BM524_RS06790	COG0033	Phosphoglucomutase
BM524_RS06795	COG0058	SHG alpha-glucan phosphorylase activity
BM524_RS06805	COG2988	succinylglutamate desuccinylase activity
BM524_RS06840	COG1393	Belongs to the ArsC family
BM524_RS06865	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BM524_RS06895	COG1621	beta-fructofuranosidase activity
BM524_RS06945	COG2080	2 iron, 2 sulfur cluster binding
BM524_RS06955	COG0281	malic enzyme
BM524_RS06960	COG3300	MHYT domain
BM524_RS06960	COG5001	Diguanylate cyclase
BM524_RS06985	COG2249	NAD(P)H dehydrogenase (quinone) activity
BM524_RS07005	COG1733	regulation of RNA biosynthetic process
BM524_RS07010	COG5001	Diguanylate cyclase
BM524_RS07010	COG3447	MASE1 domain protein
BM524_RS07010	COG5002	protein histidine kinase activity
BM524_RS07020	COG0402	S-adenosylhomocysteine deaminase activity
BM524_RS07025	COG2351	hydroxyisourate hydrolase activity
BM524_RS07040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BM524_RS07055	COG1309	transcriptional regulator
BM524_RS07070	COG2252	PERMEase
BM524_RS07075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BM524_RS07090	COG5001	Diguanylate cyclase
BM524_RS07090	COG4251	negative regulation of phosphorylation
BM524_RS07090	COG3706	GGDEF domain
BM524_RS07090	COG2203	Gaf domain
BM524_RS07095	COG0784	Response regulator, receiver
BM524_RS07095	COG2205	protein histidine kinase activity
BM524_RS07110	COG2233	PERMEase
BM524_RS07125	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BM524_RS07130	COG0730	response to heat
BM524_RS07170	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_RS07175	COG3001	Fructosamine kinase
BM524_RS07185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BM524_RS07200	COG0662	Cupin 2, conserved barrel domain protein
BM524_RS07200	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BM524_RS07205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BM524_RS07215	COG1596	polysaccharide export
BM524_RS07220	COG0489	protein tyrosine kinase activity
BM524_RS07225	COG4464	protein tyrosine phosphatase activity
BM524_RS07250	COG5001	Diguanylate cyclase
BM524_RS07250	COG3300	MHYT domain
BM524_RS07275	COG0463	Glycosyl transferase, family 2
BM524_RS07300	COG1215	transferase activity, transferring glycosyl groups
BM524_RS07305	COG0438	transferase activity, transferring glycosyl groups
BM524_RS07315	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BM524_RS07335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM524_RS07335	COG0072	phenylalanine-tRNA ligase activity
BM524_RS07360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BM524_RS07370	COG1472	Belongs to the glycosyl hydrolase 3 family
BM524_RS07375	COG2096	Adenosyltransferase
BM524_RS07385	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BM524_RS07395	COG4591	ABC-type transport system involved in lipoprotein release permease component
BM524_RS07420	COG0708	Exodeoxyribonuclease III
BM524_RS07455	COG2814	Major facilitator Superfamily
BM524_RS07490	COG4770	biotin carboxylase activity
BM524_RS07495	COG1024	Enoyl-CoA hydratase
BM524_RS07500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BM524_RS07505	COG1960	acyl-CoA dehydrogenase activity
BM524_RS07510	COG0789	Transcriptional regulator
BM524_RS07515	COG0183	Belongs to the thiolase family
BM524_RS07530	COG3706	GGDEF domain
BM524_RS07540	COG2925	Exonuclease
BM524_RS07590	COG1643	Atp-dependent helicase
BM524_RS07610	COG3321	synthase
BM524_RS07610	COG0604	alcohol dehydrogenase
BM524_RS07615	COG0328	RNA-DNA hybrid ribonuclease activity
BM524_RS07620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BM524_RS07650	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BM524_RS07655	COG1136	(ABC) transporter
BM524_RS07660	COG4591	ABC-type transport system involved in lipoprotein release permease component
BM524_RS07675	COG3724	N-succinylarginine dihydrolase activity
BM524_RS07685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BM524_RS07700	COG0746	molybdenum cofactor guanylyltransferase activity
BM524_RS07705	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BM524_RS07710	COG0243	molybdopterin cofactor binding
BM524_RS07715	COG2153	protein acetylation
BM524_RS07730	COG1530	ribonuclease E activity
BM524_RS07750	COG1399	metal-binding, possibly nucleic acid-binding protein
BM524_RS07760	COG0416	fatty acid biosynthetic process
BM524_RS07765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BM524_RS07770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BM524_RS07780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BM524_RS07785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BM524_RS07795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BM524_RS07810	COG0084	hydrolase, TatD family'
BM524_RS07820	COG0702	epimerase
BM524_RS07845	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_RS07850	COG0596	Alpha beta hydrolase
BM524_RS07860	COG0183	Belongs to the thiolase family
BM524_RS07865	COG1960	acyl-CoA dehydrogenase activity
BM524_RS07885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM524_RS07895	COG0246	Mannitol dehydrogenase
BM524_RS07920	COG0668	transmembrane transport
BM524_RS07925	COG4771	TonB-dependent receptor
BM524_RS07955	COG3437	response regulator, receiver
BM524_RS07965	COG0195	Participates in both transcription termination and antitermination
BM524_RS07980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BM524_RS07995	COG5001	Diguanylate cyclase
BM524_RS07995	COG3300	MHYT domain
BM524_RS08000	COG1187	pseudouridine synthase activity
BM524_RS08010	COG3153	acetyltransferase
BM524_RS08010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM524_RS08085	COG1032	radical SAM domain protein
BM524_RS08100	COG4771	TonB-dependent receptor
BM524_RS08105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM524_RS08115	COG4134	Bacterial extracellular solute-binding protein
BM524_RS08125	COG4136	ATPase activity
BM524_RS08130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BM524_RS08150	COG5001	Diguanylate cyclase
BM524_RS08150	COG4251	negative regulation of phosphorylation
BM524_RS08150	COG3706	GGDEF domain
BM524_RS08150	COG2203	Gaf domain
BM524_RS08170	COG0583	DNA-binding transcription factor activity
BM524_RS08190	COG1131	(ABC) transporter
BM524_RS08205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM524_RS08210	COG0385	Bile acid
BM524_RS08235	COG3311	Transcriptional regulator
BM524_RS08265	COG0582	viral genome integration into host DNA
BM524_RS08275	COG1902	pentaerythritol trinitrate reductase activity
BM524_RS08285	COG2867	negative regulation of translational initiation
BM524_RS08290	COG2914	Belongs to the UPF0125 (RnfH) family
BM524_RS08300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BM524_RS08305	COG4771	TonB-dependent receptor
BM524_RS08310	COG0457	Tetratricopeptide repeat
BM524_RS08325	COG0574	Belongs to the PEP-utilizing enzyme family
BM524_RS08325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BM524_RS08360	COG2850	peptidyl-arginine hydroxylation
BM524_RS08375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BM524_RS08380	COG2915	High frequency lysogenization protein hflD homolog
BM524_RS08385	COG0482	sulfurtransferase activity
BM524_RS08390	COG1187	pseudouridine synthase activity
BM524_RS08400	COG1278	Cold shock
BM524_RS08405	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BM524_RS08410	COG0542	response to heat
BM524_RS08415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BM524_RS08420	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BM524_RS08425	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BM524_RS08430	COG0492	ferredoxin-NADP+ reductase activity
BM524_RS08440	COG3091	SprT-like family
BM524_RS08445	COG0616	signal peptide processing
BM524_RS08460	COG0778	Nitroreductase
BM524_RS08470	COG0252	asparaginase activity
BM524_RS08475	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BM524_RS08480	COG0321	lipoyl(octanoyl) transferase activity
BM524_RS08485	COG2921	Belongs to the UPF0250 family
BM524_RS08490	COG1686	Belongs to the peptidase S11 family
BM524_RS08495	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BM524_RS08500	COG0772	Belongs to the SEDS family
BM524_RS08505	COG0768	penicillin binding
BM524_RS08510	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BM524_RS08515	COG0799	negative regulation of ribosome biogenesis
BM524_RS08525	COG1466	dna polymerase III delta subunit
BM524_RS08530	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BM524_RS08535	COG0495	leucyl-tRNA aminoacylation
BM524_RS08545	COG1067	ATP-dependent peptidase activity
BM524_RS08550	COG0596	Alpha beta hydrolase
BM524_RS08555	COG3706	GGDEF domain
BM524_RS08565	COG1534	Rna-binding protein
BM524_RS08570	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BM524_RS08575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM524_RS08580	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BM524_RS08585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BM524_RS08590	COG0149	triose-phosphate isomerase activity
BM524_RS08595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BM524_RS08605	COG5001	Diguanylate cyclase
BM524_RS08605	COG3300	MHYT domain
BM524_RS08625	COG1803	Methylglyoxal synthase
BM524_RS08625	COG1597	lipid kinase activity
BM524_RS08635	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_RS08640	COG0561	phosphatase activity
BM524_RS08655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM524_RS08660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BM524_RS08665	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BM524_RS08680	COG1185	polyribonucleotide nucleotidyltransferase activity
BM524_RS08840	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
BM524_RS08845	COG1196	nuclear chromosome segregation
BM524_RS08855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BM524_RS08870	COG1132	(ABC) transporter
BM524_RS08875	COG1663	tetraacyldisaccharide 4'-kinase activity
BM524_RS08915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BM524_RS08920	COG0435	Glutathione S-transferase
BM524_RS08925	COG1741	Belongs to the pirin family
BM524_RS08930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BM524_RS08940	COG0372	Belongs to the citrate synthase family
BM524_RS08950	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BM524_RS08955	COG1053	succinate dehydrogenase
BM524_RS08960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BM524_RS08965	COG0567	Dehydrogenase, E1 component
BM524_RS08970	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM524_RS09010	COG4667	esterase of the alpha-beta hydrolase superfamily
BM524_RS09030	COG0366	Alpha amylase catalytic
BM524_RS09055	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_RS09060	COG2267	carboxylic ester hydrolase activity
BM524_RS09070	COG0616	signal peptide processing
BM524_RS09090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM524_RS09095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BM524_RS09100	COG0386	Belongs to the glutathione peroxidase family
BM524_RS09105	COG2084	Dehydrogenase
BM524_RS09115	COG1960	acyl-CoA dehydrogenase activity
BM524_RS09120	COG1024	Enoyl-CoA hydratase
BM524_RS09125	COG2226	methyltransferase
BM524_RS09130	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BM524_RS09135	COG3083	sulfuric ester hydrolase activity
BM524_RS09140	COG3082	Protein of unknown function (DUF1414)
BM524_RS09145	COG3081	Nucleoid-associated protein
BM524_RS09175	COG3275	phosphorelay sensor kinase activity
BM524_RS09180	COG3279	Response regulator of the LytR AlgR family
BM524_RS09185	COG0205	6-phosphofructokinase activity
BM524_RS09195	COG0789	Transcriptional regulator
BM524_RS09245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM524_RS09245	COG2205	protein histidine kinase activity
BM524_RS09255	COG1054	Belongs to the UPF0176 family
BM524_RS09265	COG0513	Belongs to the DEAD box helicase family
BM524_RS09275	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BM524_RS09280	COG0583	DNA-binding transcription factor activity
BM524_RS09300	COG1760	l-serine dehydratase
BM524_RS09325	COG1322	Protein conserved in bacteria
BM524_RS09330	COG1404	Belongs to the peptidase S8 family
BM524_RS09335	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BM524_RS09340	COG0022	dehydrogenase e1 component
BM524_RS09350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BM524_RS09355	COG0515	serine threonine protein kinase
BM524_RS09360	COG1946	Acyl-CoA thioesterase
BM524_RS09370	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BM524_RS09380	COG1956	GAF domain-containing protein
BM524_RS09395	COG0793	Belongs to the peptidase S41A family
BM524_RS09400	COG0733	neurotransmitter:sodium symporter activity
BM524_RS09405	COG1757	Na H antiporter
BM524_RS09410	COG0308	aminopeptidase N
BM524_RS09440	COG2902	Dehydrogenase
BM524_RS09445	COG0167	dihydroorotate dehydrogenase activity
BM524_RS09460	COG0488	(ABC) transporter
BM524_RS09470	COG3130	regulation of translation
BM524_RS09475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BM524_RS09485	COG0415	Belongs to the DNA photolyase family
BM524_RS09490	COG0415	Belongs to the DNA photolyase family
BM524_RS09495	COG0415	Belongs to the DNA photolyase family
BM524_RS09500	COG3046	protein related to deoxyribodipyrimidine photolyase
BM524_RS09535	COG1082	Xylose isomerase domain protein TIM barrel
BM524_RS09565	COG4974	Belongs to the 'phage' integrase family
BM524_RS09575	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BM524_RS09580	COG0589	response to stress
BM524_RS09590	COG0069	glutamate synthase activity
BM524_RS09605	COG2193	ferroxidase activity
BM524_RS09615	COG3278	Belongs to the heme-copper respiratory oxidase family
BM524_RS09630	COG2010	Cytochrome c
BM524_RS09655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM524_RS09660	COG0589	response to stress
BM524_RS09665	COG0037	tRNA processing
BM524_RS09670	COG1752	Esterase of the alpha-beta hydrolase superfamily
BM524_RS09690	COG1280	lysine exporter protein (LysE YggA)
BM524_RS09700	COG2897	thiosulfate sulfurtransferase activity
BM524_RS09705	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BM524_RS09710	COG3148	PFAM DTW domain containing protein
BM524_RS09735	COG0322	excinuclease ABC activity
BM524_RS09740	COG2197	response regulator
BM524_RS09745	COG0436	Aminotransferase
BM524_RS09750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BM524_RS09765	COG0583	DNA-binding transcription factor activity
BM524_RS09770	COG2259	Doxx family
BM524_RS09780	COG0670	Belongs to the BI1 family
BM524_RS09785	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BM524_RS09800	COG2920	part of a sulfur-relay system
BM524_RS09830	COG4206	TonB-dependent receptor
BM524_RS09830	COG4206	TonB-dependent receptor
BM524_RS09845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BM524_RS09855	COG0531	amino acid
BM524_RS09855	COG1674	ftsk spoiiie
BM524_RS09865	COG0686	Belongs to the AlaDH PNT family
BM524_RS09870	COG0284	orotidine-5'-phosphate decarboxylase activity
BM524_RS09875	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BM524_RS09890	COG0776	regulation of translation
BM524_RS09895	COG0539	negative regulation of cytoplasmic translation
BM524_RS09900	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BM524_RS09905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BM524_RS09910	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BM524_RS09920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM524_RS09925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BM524_RS09930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BM524_RS09935	COG0633	Ferredoxin
BM524_RS09970	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BM524_RS09975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BM524_RS09985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BM524_RS09995	COG4783	chaperone-mediated protein folding
BM524_RS10005	COG1393	Belongs to the ArsC family
BM524_RS10020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BM524_RS10035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BM524_RS10045	COG1960	acyl-CoA dehydrogenase activity
BM524_RS10070	COG0572	uridine kinase
BM524_RS10075	COG3769	mannosylglycerate metabolic process
BM524_RS10080	COG1215	transferase activity, transferring glycosyl groups
BM524_RS10085	COG0366	Alpha amylase catalytic
BM524_RS10095	COG0303	'Molybdopterin
BM524_RS10100	COG0534	Mate efflux family protein
BM524_RS10115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM524_RS10120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BM524_RS10160	COG3547	Transposase (IS116 IS110 IS902 family)
BM524_RS10185	COG0405	Gamma-glutamyltransferase
BM524_RS10190	COG1024	Enoyl-CoA hydratase
BM524_RS10250	COG1671	Belongs to the UPF0178 family
BM524_RS10255	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_RS10260	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_RS10265	COG1960	acyl-CoA dehydrogenase activity
BM524_RS10270	COG2207	Transcriptional regulator
BM524_RS10270	COG0662	Cupin 2, conserved barrel domain protein
BM524_RS10275	COG4771	TonB-dependent receptor
BM524_RS10285	COG1505	serine-type exopeptidase activity
BM524_RS10295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_RS10325	COG0596	Alpha beta hydrolase
BM524_RS10335	COG0716	FMN binding
BM524_RS10345	COG0735	belongs to the Fur family
BM524_RS10355	COG1984	allophanate hydrolase subunit 2
BM524_RS10360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BM524_RS10365	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BM524_RS10370	COG2996	Protein conserved in bacteria
BM524_RS10375	COG1765	OsmC-like protein
BM524_RS10380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_RS10390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM524_RS10405	COG0436	Aminotransferase
BM524_RS10410	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BM524_RS10415	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BM524_RS10440	COG3012	SEC-C Motif Domain Protein
BM524_RS10445	COG5002	protein histidine kinase activity
BM524_RS10445	COG5001	Diguanylate cyclase
BM524_RS10445	COG3447	MASE1 domain protein
BM524_RS10450	COG0366	Alpha amylase catalytic
BM524_RS10460	COG0604	alcohol dehydrogenase
BM524_RS10470	COG1960	acyl-CoA dehydrogenase activity
BM524_RS10480	COG4771	TonB-dependent receptor
BM524_RS10500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BM524_RS10505	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BM524_RS10525	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BM524_RS10530	COG0315	cyclic pyranopterin monophosphate synthase activity
BM524_RS10535	COG0521	Mo-molybdopterin cofactor biosynthetic process
BM524_RS10540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BM524_RS10550	COG2161	toxin-antitoxin pair type II binding
BM524_RS10555	COG4115	mRNA cleavage
BM524_RS10570	COG0436	Aminotransferase
BM524_RS10575	COG3268	Saccharopine dehydrogenase
BM524_RS10580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM524_RS10600	COG4206	TonB-dependent receptor
BM524_RS10610	COG5006	permease, DMT superfamily
BM524_RS10635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM524_RS10640	COG1074	ATP-dependent DNA helicase activity
BM524_RS10645	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BM524_RS10655	COG1022	Amp-dependent synthetase and ligase
BM524_RS10660	COG3706	GGDEF domain
BM524_RS10660	COG5001	Diguanylate cyclase
BM524_RS10660	COG2203	Gaf domain
BM524_RS10660	COG4251	negative regulation of phosphorylation
BM524_RS10680	COG0583	DNA-binding transcription factor activity
BM524_RS10695	COG0640	Transcriptional regulator
BM524_RS10715	COG2204	response regulator
BM524_RS10725	COG4251	negative regulation of phosphorylation
BM524_RS10730	COG0784	Response regulator, receiver
BM524_RS10735	COG0784	Response regulator, receiver
BM524_RS10735	COG2205	protein histidine kinase activity
BM524_RS10760	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BM524_RS10785	COG3139	Protein of unknown function (DUF1315)
BM524_RS10800	COG1115	amino acid carrier protein
BM524_RS10805	COG2866	Carboxypeptidase
BM524_RS10825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BM524_RS10835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BM524_RS10840	COG1640	4-alpha-glucanotransferase
BM524_RS10845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BM524_RS10850	COG0676	glucose-6-phosphate 1-epimerase activity
BM524_RS10855	COG0800	Aldolase
BM524_RS10865	COG0129	dihydroxy-acid dehydratase activity
BM524_RS10875	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BM524_RS10880	COG1737	Transcriptional regulator
BM524_RS10885	COG0469	pyruvate kinase activity
BM524_RS10890	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BM524_RS10905	COG2823	Periplasmic or secreted lipoprotein
BM524_RS10935	COG3665	Urea carboxylase-associated protein
BM524_RS10955	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_RS10960	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BM524_RS10970	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BM524_RS10985	COG2721	sulfolactate sulfo-lyase activity
BM524_RS10990	COG1904	glucuronate isomerase
BM524_RS10995	COG0246	Mannitol dehydrogenase
BM524_RS11000	COG0800	Aldolase
BM524_RS11005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM524_RS11010	COG2755	lipolytic protein G-D-S-L family
BM524_RS11020	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BM524_RS11045	COG2356	endonuclease I
BM524_RS11050	COG0840	transmembrane signaling receptor activity
BM524_RS11065	COG0583	DNA-binding transcription factor activity
BM524_RS11070	COG1979	alcohol dehydrogenase
BM524_RS11075	COG5001	Diguanylate cyclase
BM524_RS11085	COG0784	Response regulator, receiver
BM524_RS11085	COG3437	response regulator, receiver
BM524_RS11090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM524_RS11090	COG4191	Histidine kinase
BM524_RS11105	COG0471	metal ion transport
BM524_RS11115	COG0489	protein tyrosine kinase activity
BM524_RS11120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM524_RS11120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM524_RS11125	COG0668	transmembrane transport
BM524_RS11130	COG2226	methyltransferase
BM524_RS11135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM524_RS11140	COG1388	LysM domain
BM524_RS11140	COG0741	lytic transglycosylase activity
BM524_RS11150	COG0215	cysteine-tRNA ligase activity
BM524_RS11155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM524_RS11160	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BM524_RS11170	COG2268	Band 7 protein
BM524_RS11185	COG1733	regulation of RNA biosynthetic process
BM524_RS11190	COG0604	alcohol dehydrogenase
BM524_RS11195	COG0753	catalase activity
BM524_RS11200	COG0604	alcohol dehydrogenase
BM524_RS11205	COG0583	DNA-binding transcription factor activity
BM524_RS11230	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BM524_RS11235	COG1286	toxin biosynthetic process
BM524_RS11240	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
BM524_RS11245	COG0285	dihydrofolate synthase activity
BM524_RS11265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BM524_RS11270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BM524_RS11290	COG3609	addiction module antidote protein, CC2985 family
BM524_RS11300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BM524_RS11315	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BM524_RS11315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BM524_RS11345	COG0604	alcohol dehydrogenase
BM524_RS11370	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_RS11375	COG1119	ATPase activity
BM524_RS11380	COG2031	fatty acid transporter
BM524_RS11385	COG0784	Response regulator, receiver
BM524_RS11385	COG2205	protein histidine kinase activity
BM524_RS11385	COG5002	protein histidine kinase activity
BM524_RS11395	COG0612	Peptidase, M16
BM524_RS11410	COG3101	peptidyl-lysine hydroxylation
BM524_RS11440	COG0446	pyridine nucleotide-disulphide oxidoreductase
BM524_RS11440	COG1902	pentaerythritol trinitrate reductase activity
BM524_RS11465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BM524_RS11475	COG4399	Belongs to the UPF0754 family
BM524_RS11500	COG1770	oligopeptidase
BM524_RS11505	COG2186	Transcriptional regulator
BM524_RS11515	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BM524_RS11520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BM524_RS11530	COG2983	Belongs to the UPF0260 family
BM524_RS11535	COG0179	Fumarylacetoacetate (FAA) hydrolase
BM524_RS11550	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BM524_RS11555	COG0318	PFAM AMP-dependent synthetase and ligase
BM524_RS11560	COG2267	carboxylic ester hydrolase activity
BM524_RS11575	COG1214	PFAM Peptidase M22, glycoprotease
BM524_RS11580	COG1199	ATP-dependent helicase activity
BM524_RS11635	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BM524_RS11640	COG4771	TonB-dependent receptor
BM524_RS11650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BM524_RS11655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BM524_RS11660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM524_RS11665	COG0131	Imidazoleglycerol-phosphate dehydratase
BM524_RS11665	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BM524_RS11670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BM524_RS11685	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BM524_RS11685	COG0140	phosphoribosyl-ATP diphosphatase activity
BM524_RS11690	COG2116	formate transmembrane transporter activity
BM524_RS11695	COG0840	transmembrane signaling receptor activity
BM524_RS11725	COG0326	Molecular chaperone. Has ATPase activity
BM524_RS11730	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BM524_RS11750	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BM524_RS11755	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BM524_RS11765	COG3220	belongs to the UPF0276 family
BM524_RS11785	COG3706	GGDEF domain
BM524_RS11785	COG2203	Gaf domain
BM524_RS11785	COG5001	Diguanylate cyclase
BM524_RS11785	COG4251	negative regulation of phosphorylation
BM524_RS11815	COG1183	phosphatidylcholine synthase activity
BM524_RS11835	COG0277	FAD linked oxidase domain protein
BM524_RS11840	COG0542	response to heat
BM524_RS11845	COG1496	oxidoreductase activity
BM524_RS11865	COG1595	DNA-templated transcription, initiation
BM524_RS11880	COG4221	oxidoreductase activity
BM524_RS11895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BM524_RS11905	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BM524_RS11915	COG0142	geranyltranstransferase activity
BM524_RS11925	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BM524_RS11930	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BM524_RS11940	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BM524_RS11955	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BM524_RS11955	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BM524_RS11970	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BM524_RS11975	COG0488	(ABC) transporter
BM524_RS11985	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BM524_RS11995	COG0560	Phosphoserine phosphatase
BM524_RS12005	COG0084	hydrolase, TatD family'
BM524_RS12015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BM524_RS12020	COG0571	ribonuclease III activity
BM524_RS12050	COG1595	DNA-templated transcription, initiation
BM524_RS12055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BM524_RS12070	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BM524_RS12150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BM524_RS12155	COG1047	Peptidyl-prolyl cis-trans
BM524_RS12165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BM524_RS12170	COG0196	riboflavin kinase activity
BM524_RS12175	COG0728	peptidoglycan biosynthetic process
BM524_RS12180	COG0268	Binds directly to 16S ribosomal RNA
BM524_RS12195	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_RS12200	COG0385	Bile acid
BM524_RS12205	COG0583	DNA-binding transcription factor activity
BM524_RS12235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM524_RS12240	COG0776	regulation of translation
BM524_RS12245	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BM524_RS12250	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BM524_RS12255	COG0740	serine-type endopeptidase activity
BM524_RS12260	COG0544	peptidyl-prolyl cis-trans isomerase activity
BM524_RS12300	COG1720	tRNA m6t6A37 methyltransferase activity
BM524_RS12310	COG1234	tRNA 3'-trailer cleavage
BM524_RS12320	COG0123	including yeast histone deacetylase and acetoin utilization protein
BM524_RS12335	COG0516	GMP reductase activity
BM524_RS12335	COG0517	IMP dehydrogenase activity
BM524_RS12340	COG1570	exodeoxyribonuclease VII activity
BM524_RS12360	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM524_RS12365	COG2976	Protein conserved in bacteria
BM524_RS12390	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BM524_RS12400	COG2166	iron-sulfur cluster assembly
BM524_RS12415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BM524_RS12420	COG0719	Fe-S assembly protein
BM524_RS12425	COG0396	ATPase activity
BM524_RS12430	COG0719	Fe-S assembly protein
BM524_RS12435	COG1104	cysteine desulfurase activity
BM524_RS12440	COG1959	2 iron, 2 sulfur cluster binding
BM524_RS12445	COG2072	flavoprotein involved in K transport
BM524_RS12450	COG1045	serine acetyltransferase
BM524_RS12455	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BM524_RS12460	COG0483	inositol monophosphate 1-phosphatase activity
BM524_RS12475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM524_RS12480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM524_RS12485	COG1862	Preprotein translocase
BM524_RS12490	COG0343	queuine tRNA-ribosyltransferase activity
BM524_RS12510	COG1842	Phage shock protein A
BM524_RS12515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BM524_RS12535	COG0754	glutathionylspermidine amidase activity
BM524_RS12565	COG2066	Belongs to the glutaminase family
BM524_RS12570	COG1785	Belongs to the alkaline phosphatase family
BM524_RS12575	COG0745	RESPONSE REGULATOR receiver
BM524_RS12675	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BM524_RS12680	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BM524_RS12700	COG0297	glycogen (starch) synthase activity
BM524_RS12705	COG0367	asparagine synthase
BM524_RS12715	COG0463	Glycosyl transferase, family 2
BM524_RS12725	COG1216	Glycosyl transferase, family 2
BM524_RS12745	COG0367	asparagine synthase
BM524_RS12780	COG0489	protein tyrosine kinase activity
BM524_RS12790	COG3409	Peptidoglycan-binding domain 1 protein
BM524_RS12790	COG3267	Type II secretory pathway component ExeA
BM524_RS12795	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BM524_RS12795	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BM524_RS12825	COG1560	Kdo2-lipid A biosynthetic process
BM524_RS12840	COG1960	acyl-CoA dehydrogenase activity
BM524_RS12855	COG3300	MHYT domain
BM524_RS12855	COG5001	Diguanylate cyclase
BM524_RS12860	COG1435	thymidine kinase activity
BM524_RS12870	COG1609	Transcriptional regulator
BM524_RS12875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BM524_RS12905	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BM524_RS12910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM524_RS12915	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM524_RS12915	COG1024	Enoyl-CoA hydratase
BM524_RS12930	COG1012	belongs to the aldehyde dehydrogenase family
BM524_RS12950	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
BM524_RS12955	COG0789	Transcriptional regulator
BM524_RS12985	COG1960	acyl-CoA dehydrogenase activity
BM524_RS13010	COG0745	RESPONSE REGULATOR receiver
BM524_RS13015	COG2205	protein histidine kinase activity
BM524_RS13055	COG2080	2 iron, 2 sulfur cluster binding
BM524_RS13060	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BM524_RS13065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BM524_RS13085	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_RS13090	COG4221	oxidoreductase activity
BM524_RS13095	COG0693	protein deglycase activity
BM524_RS13100	COG1295	ribonuclease BN
BM524_RS13145	COG2814	Major facilitator Superfamily
BM524_RS13165	COG0514	ATP-dependent DNA helicase (RecQ)
BM524_RS13195	COG4251	negative regulation of phosphorylation
BM524_RS13200	COG2133	pyrroloquinoline quinone binding
BM524_RS13205	COG3609	addiction module antidote protein, CC2985 family
BM524_RS13270	COG2826	transposase and inactivated derivatives, IS30 family
BM524_RS13275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BM524_RS13275	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BM524_RS13290	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BM524_RS13295	COG2971	BadF BadG BcrA BcrD
BM524_RS13300	COG0583	DNA-binding transcription factor activity
BM524_RS13305	COG1620	l-lactate permease
BM524_RS13325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM524_RS13330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM524_RS13335	COG0006	proline dipeptidase activity
BM524_RS13350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM524_RS13365	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BM524_RS13370	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BM524_RS13375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BM524_RS13395	COG3313	Fe-S protein
BM524_RS13430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM524_RS13435	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM524_RS13440	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BM524_RS13455	COG3023	N-Acetylmuramoyl-L-alanine amidase
BM524_RS13460	COG3577	Aspartyl protease
BM524_RS13465	COG0157	Belongs to the NadC ModD family
BM524_RS13475	COG1459	type II secretion system
BM524_RS13480	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BM524_RS13485	COG0237	dephospho-CoA kinase activity
BM524_RS13485	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BM524_RS13490	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BM524_RS13495	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BM524_RS13500	COG3608	succinylglutamate desuccinylase aspartoacylase
BM524_RS13505	COG0494	nUDIX hydrolase
BM524_RS13515	COG0739	heme binding
BM524_RS13520	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BM524_RS13525	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BM524_RS13530	COG0849	cell division
BM524_RS13535	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BM524_RS13540	COG1181	Belongs to the D-alanine--D-alanine ligase family
BM524_RS13545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BM524_RS13555	COG0772	Belongs to the SEDS family
BM524_RS13560	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BM524_RS13570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BM524_RS13575	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BM524_RS13580	COG0768	penicillin binding
BM524_RS13585	COG3116	cell division
BM524_RS13595	COG2001	Belongs to the MraZ family
BM524_RS13615	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM524_RS13620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_RS13640	COG0678	peroxiredoxin activity
BM524_RS13640	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BM524_RS13665	COG2204	response regulator
BM524_RS13670	COG0784	Response regulator, receiver
BM524_RS13670	COG2205	protein histidine kinase activity
BM524_RS13685	COG2271	Major facilitator Superfamily
BM524_RS13710	COG0668	transmembrane transport
BM524_RS13715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BM524_RS13720	COG0189	ligase activity
BM524_RS13725	COG1678	Uncharacterized ACR, COG1678
BM524_RS13730	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BM524_RS13755	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BM524_RS13760	COG0762	integral membrane protein
BM524_RS13770	COG0446	pyridine nucleotide-disulphide oxidoreductase
BM524_RS13770	COG1902	pentaerythritol trinitrate reductase activity
BM524_RS13785	COG0625	glutathione transferase activity
BM524_RS13795	COG1764	response to oxidative stress
BM524_RS13800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM524_RS13815	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BM524_RS13820	COG1396	sequence-specific DNA binding
BM524_RS13825	COG2814	Major facilitator Superfamily
BM524_RS13830	COG0724	RNA recognition motif
BM524_RS13860	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BM524_RS13865	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BM524_RS13870	COG0083	homoserine kinase activity
BM524_RS13885	COG0583	DNA-binding transcription factor activity
BM524_RS13900	COG0640	Transcriptional regulator
BM524_RS13910	COG0431	NADPH-dependent FMN reductase
BM524_RS13915	COG0798	PFAM Bile acid sodium symporter
BM524_RS13920	COG2201	protein-glutamate methylesterase activity
BM524_RS13925	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BM524_RS13935	COG3850	Histidine kinase
BM524_RS13935	COG5002	protein histidine kinase activity
BM524_RS13950	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BM524_RS13980	COG1748	Saccharopine dehydrogenase
BM524_RS13995	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BM524_RS14000	COG3107	peptidoglycan biosynthetic process
BM524_RS14020	COG2823	Periplasmic or secreted lipoprotein
BM524_RS14050	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BM524_RS14055	COG0372	Belongs to the citrate synthase family
BM524_RS14060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BM524_RS14065	COG2828	Protein conserved in bacteria
BM524_RS14070	COG2199	diguanylate cyclase activity
BM524_RS14070	COG2203	Gaf domain
BM524_RS14090	COG0784	Response regulator, receiver
BM524_RS14090	COG2198	Histidine kinase
BM524_RS14090	COG5002	protein histidine kinase activity
BM524_RS14095	COG3023	N-Acetylmuramoyl-L-alanine amidase
BM524_RS14100	COG0070	glutamate synthase
BM524_RS14100	COG0069	glutamate synthase activity
BM524_RS14100	COG0067	glutamate synthase
BM524_RS14105	COG0493	'glutamate synthase
BM524_RS14125	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BM524_RS14130	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BM524_RS14135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BM524_RS14140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM524_RS14155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BM524_RS14160	COG5507	3-demethylubiquinone-9 3-methyltransferase
BM524_RS14165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BM524_RS14170	COG4942	peptidase
BM524_RS14175	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BM524_RS14180	COG0738	Major facilitator superfamily
BM524_RS14185	COG1902	pentaerythritol trinitrate reductase activity
BM524_RS14205	COG0625	glutathione transferase activity
BM524_RS14230	COG2894	cell division
BM524_RS14235	COG0850	regulation of cytokinetic process
BM524_RS14245	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BM524_RS14265	COG1981	membrane
BM524_RS14280	COG1914	H( )-stimulated, divalent metal cation uptake system
BM524_RS14295	COG1217	gtp-binding protein TYPA
BM524_RS14300	COG0174	glutamine synthetase
BM524_RS14310	COG3852	Histidine kinase
BM524_RS14315	COG2204	response regulator
BM524_RS14320	COG3437	response regulator, receiver
BM524_RS14360	COG4999	Histidine kinase
BM524_RS14360	COG3437	response regulator, receiver
BM524_RS14360	COG3850	Histidine kinase
BM524_RS14360	COG2205	protein histidine kinase activity
BM524_RS14365	COG0525	valine-tRNA ligase activity
BM524_RS14370	COG2927	DNA polymerase III (CHI subunit)
BM524_RS14375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BM524_RS14380	COG0795	lipopolysaccharide-transporting ATPase activity
BM524_RS14385	COG0795	lipopolysaccharide-transporting ATPase activity
BM524_RS14455	COG3459	Glycosyltransferase 36 associated
BM524_RS14465	COG2199	diguanylate cyclase activity
BM524_RS14465	COG2203	Gaf domain
BM524_RS14495	COG0673	inositol 2-dehydrogenase activity
BM524_RS14500	COG2205	protein histidine kinase activity
BM524_RS14500	COG2198	Histidine kinase
BM524_RS14500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM524_RS14500	COG0784	Response regulator, receiver
BM524_RS14505	COG0628	permease
BM524_RS14520	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BM524_RS14525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BM524_RS14530	COG4558	Periplasmic binding protein
BM524_RS14540	COG4206	TonB-dependent receptor
BM524_RS14550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BM524_RS14575	COG4447	cellulose binding
BM524_RS14585	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BM524_RS14595	COG0006	proline dipeptidase activity
BM524_RS14600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BM524_RS14610	COG0679	Auxin Efflux Carrier
BM524_RS14620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM524_RS14630	COG0395	ABC-type sugar transport system, permease component
BM524_RS14650	COG2267	carboxylic ester hydrolase activity
BM524_RS14680	COG1131	(ABC) transporter
BM524_RS14690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BM524_RS14745	COG2205	protein histidine kinase activity
BM524_RS14755	COG3901	Regulator of nitric oxide reductase transcription
BM524_RS14755	COG0348	domain, Protein
BM524_RS14765	COG2197	response regulator
BM524_RS14790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BM524_RS14795	COG0277	FAD linked oxidase domain protein
BM524_RS14805	COG1462	curli production assembly transport component CsgG
BM524_RS14835	COG2197	response regulator
BM524_RS14860	COG0513	Belongs to the DEAD box helicase family
BM524_RS14865	COG5001	Diguanylate cyclase
BM524_RS14880	COG0800	Aldolase
BM524_RS14885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM524_RS14900	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BM524_RS14900	COG3264	Mechanosensitive ion channel
BM524_RS14940	COG0730	response to heat
BM524_RS14945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM524_RS14960	COG4191	Histidine kinase
BM524_RS14970	COG0417	DNA replication proofreading
BM524_RS14980	COG0318	PFAM AMP-dependent synthetase and ligase
BM524_RS15025	COG1309	transcriptional regulator
BM524_RS15035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM524_RS15045	COG1573	uracil-dna glycosylase
BM524_RS15050	COG3300	MHYT domain
BM524_RS15050	COG5001	Diguanylate cyclase
BM524_RS15070	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BM524_RS15090	COG1983	PspC domain protein
BM524_RS15095	COG1842	Phage shock protein A
BM524_RS15105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM524_RS15110	COG0582	viral genome integration into host DNA
BM524_RS15170	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BM524_RS15240	COG1621	beta-fructofuranosidase activity
BM524_RS15255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BM524_RS15265	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BM524_RS15270	COG0204	Acyl-transferase
BM524_RS15275	COG0204	Acyl-transferase
BM524_RS15280	COG0668	transmembrane transport
BM524_RS15295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM524_RS15300	COG0733	neurotransmitter:sodium symporter activity
BM524_RS15315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM524_RS15340	COG0848	biopolymer transport protein
BM524_RS15355	COG0457	Tetratricopeptide repeat
BM524_RS15360	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BM524_RS15370	COG1215	transferase activity, transferring glycosyl groups
BM524_RS15385	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BM524_RS15390	COG0702	epimerase
BM524_RS15410	COG5002	protein histidine kinase activity
BM524_RS15410	COG5001	Diguanylate cyclase
BM524_RS15420	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BM524_RS15430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM524_RS15440	COG0583	DNA-binding transcription factor activity
BM524_RS15445	COG0121	glutamine amidotransferase
BM524_RS15455	COG4682	membrane
BM524_RS15490	COG4628	conserved protein (DUF2132)
BM524_RS15495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM524_RS15505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BM524_RS15520	COG1477	protein flavinylation
BM524_RS15525	COG2871	sodium ion transport
BM524_RS15530	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM524_RS15535	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM524_RS15540	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM524_RS15545	COG1805	sodium ion transport
BM524_RS15550	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM524_RS15555	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BM524_RS15560	COG0545	Peptidyl-prolyl cis-trans isomerase
BM524_RS15565	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BM524_RS15580	COG0039	L-malate dehydrogenase activity
BM524_RS15585	COG1438	arginine binding
BM524_RS15610	COG0572	uridine kinase
BM524_RS15615	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BM524_RS15640	COG2176	DNA-directed DNA polymerase activity
BM524_RS15650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM524_RS15660	COG2205	protein histidine kinase activity
BM524_RS15670	COG0189	ligase activity
BM524_RS15680	COG4067	protein conserved in archaea
BM524_RS15680	COG0189	ligase activity
BM524_RS15695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BM524_RS15705	COG1283	sodium-dependent phosphate transmembrane transporter activity
BM524_RS15710	COG0667	Aldo Keto reductase
BM524_RS15735	COG2815	serine threonine protein kinase
BM524_RS15735	COG0515	serine threonine protein kinase
BM524_RS15795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BM524_RS15825	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BM524_RS15835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BM524_RS15840	COG0840	transmembrane signaling receptor activity
BM524_RS15880	COG2274	protein secretion by the type I secretion system
BM524_RS15885	COG0583	DNA-binding transcription factor activity
BM524_RS15920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BM524_RS15935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BM524_RS15985	COG2244	polysaccharide biosynthetic process
BM524_RS16005	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BM524_RS16015	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BM524_RS16020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BM524_RS16035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BM524_RS16050	COG0202	RNA polymerase activity
BM524_RS16075	COG0201	protein transport
BM524_RS16095	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BM524_RS16130	COG0784	Response regulator, receiver
BM524_RS16130	COG5002	protein histidine kinase activity
BM524_RS16145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM524_RS16150	COG0557	exoribonuclease II activity
BM524_RS16170	COG4771	TonB-dependent receptor
BM524_RS16185	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BM524_RS16200	COG0543	2 iron, 2 sulfur cluster binding
BM524_RS16210	COG2234	aminopeptidase activity
BM524_RS16220	COG4251	negative regulation of phosphorylation
BM524_RS16230	COG1271	oxidase subunit
BM524_RS16235	COG1294	oxidase, subunit
BM524_RS16240	COG1522	sequence-specific DNA binding
BM524_RS16250	COG1278	Cold shock
BM524_RS16255	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM524_RS16275	COG0339	signal peptide processing
BM524_RS16280	COG2201	protein-glutamate methylesterase activity
BM524_RS16290	COG3852	Histidine kinase
BM524_RS16300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM524_RS16305	COG0243	molybdopterin cofactor binding
BM524_RS16310	COG0823	Involved in the tonB-independent uptake of proteins
BM524_RS16310	COG4946	Tricorn protease homolog
BM524_RS16310	COG1506	peptidase
BM524_RS16355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_RS16365	COG2197	response regulator
BM524_RS16395	COG1621	beta-fructofuranosidase activity
BM524_RS16400	COG2814	Major facilitator Superfamily
BM524_RS16405	COG0702	epimerase
BM524_RS16410	COG4771	TonB-dependent receptor
BM524_RS16420	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BM524_RS16425	COG1278	Cold shock
BM524_RS16435	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BM524_RS16440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BM524_RS16455	COG0281	malic enzyme
BM524_RS16465	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BM524_RS16495	COG0456	acetyltransferase
BM524_RS16505	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BM524_RS16510	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BM524_RS16515	COG2177	Part of the ABC transporter FtsEX involved in
BM524_RS16520	COG2884	Cell division ATP-binding protein ftsE
BM524_RS16525	COG0552	protein localization to endoplasmic reticulum
BM524_RS16535	COG0742	ribosomal rna small subunit methyltransferase
BM524_RS16545	COG2095	MarC family integral membrane protein
BM524_RS16570	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BM524_RS16575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM524_RS16580	COG0617	tRNA 3'-terminal CCA addition
BM524_RS16585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BM524_RS16600	COG0076	glutamate decarboxylase activity
BM524_RS16615	COG0842	Transport permease protein
BM524_RS16620	COG1131	(ABC) transporter
BM524_RS16625	COG0745	RESPONSE REGULATOR receiver
BM524_RS16630	COG2205	protein histidine kinase activity
BM524_RS16635	COG4774	siderophore transport
BM524_RS16655	COG1253	flavin adenine dinucleotide binding
BM524_RS16665	COG1966	Carbon starvation protein
BM524_RS16675	COG0657	acetylesterase activity
BM524_RS16685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BM524_RS16695	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BM524_RS16700	COG0049	tRNA binding
BM524_RS16705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BM524_RS16710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BM524_RS16715	COG0085	RNA polymerase activity
BM524_RS16720	COG0222	ribosome binding
BM524_RS16725	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BM524_RS16730	COG0081	regulation of translation
BM524_RS16735	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BM524_RS16755	COG0250	Participates in transcription elongation, termination and antitermination
BM524_RS16760	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BM524_RS16770	COG1132	(ABC) transporter
BM524_RS16775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BM524_RS16780	COG3590	peptidase
BM524_RS16790	COG0513	Belongs to the DEAD box helicase family
BM524_RS16795	COG0418	dihydroorotase activity
BM524_RS16800	COG3040	lipid binding
BM524_RS16805	COG4989	oxidoreductase activity
BM524_RS16810	COG0346	lactoylglutathione lyase activity
BM524_RS16815	COG0668	transmembrane transport
BM524_RS16835	COG0302	gtp cyclohydrolase
BM524_RS16845	COG2957	Belongs to the agmatine deiminase family
BM524_RS16850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM524_RS16860	COG1201	RNA secondary structure unwinding
BM524_RS16870	COG1793	dna ligase
BM524_RS16875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BM524_RS16880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM524_RS16895	COG0625	glutathione transferase activity
BM524_RS16900	COG0625	glutathione transferase activity
BM524_RS16910	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BM524_RS16925	COG1012	belongs to the aldehyde dehydrogenase family
BM524_RS16930	COG0028	Belongs to the TPP enzyme family
BM524_RS16940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BM524_RS16945	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BM524_RS16950	COG0330	HflC and HflK could
BM524_RS16955	COG0330	HflC and HflK could
BM524_RS16960	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BM524_RS16965	COG1923	regulation of RNA biosynthetic process
BM524_RS16970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BM524_RS16985	COG0802	atpase or kinase
BM524_RS16990	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BM524_RS16990	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BM524_RS16995	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BM524_RS17015	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
BM524_RS17020	COG0735	belongs to the Fur family
BM524_RS17040	COG0305	Participates in initiation and elongation during chromosome replication
BM524_RS17065	COG2258	MOSC domain
BM524_RS17125	COG2205	protein histidine kinase activity
BM524_RS17125	COG0784	Response regulator, receiver
BM524_RS17125	COG2198	Histidine kinase
BM524_RS17135	COG1136	(ABC) transporter
BM524_RS17135	COG0577	efflux transmembrane transporter activity
BM524_RS17145	COG0840	transmembrane signaling receptor activity
BM524_RS17150	COG5002	protein histidine kinase activity
BM524_RS17155	COG0840	transmembrane signaling receptor activity
BM524_RS17170	COG2855	membrane
BM524_RS17175	COG2175	clavaminate synthase activity
BM524_RS17180	COG0656	L-ascorbic acid biosynthetic process
BM524_RS17200	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM524_RS17205	COG4771	TonB-dependent receptor
BM524_RS17225	COG1757	Na H antiporter
BM524_RS17230	COG1472	Belongs to the glycosyl hydrolase 3 family
BM524_RS17240	COG2723	6-phospho-beta-galactosidase activity
BM524_RS17245	COG1609	Transcriptional regulator
BM524_RS17250	COG2814	Major facilitator Superfamily
BM524_RS17250	COG0477	Major facilitator Superfamily
BM524_RS17255	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BM524_RS17260	COG4988	ABC transporter
BM524_RS17265	COG4890	Cyd operon protein YbgT
BM524_RS17270	COG1294	oxidase, subunit
BM524_RS17310	COG4319	ketosteroid isomerase
BM524_RS17330	COG2375	cellular response to nickel ion
BM524_RS17335	COG3237	CsbD-like
BM524_RS17350	COG1595	DNA-templated transcription, initiation
BM524_RS17355	COG1404	Belongs to the peptidase S8 family
BM524_RS17380	COG0596	Alpha beta hydrolase
BM524_RS17380	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM524_RS17400	COG3038	cytochrome b561
BM524_RS17410	COG1252	NADH dehydrogenase
BM524_RS17425	COG0583	DNA-binding transcription factor activity
BM524_RS17430	COG2067	long-chain fatty acid transport protein
BM524_RS17435	COG2130	NADP-dependent
BM524_RS17440	COG3706	GGDEF domain
BM524_RS17440	COG2203	Gaf domain
BM524_RS17440	COG4251	negative regulation of phosphorylation
BM524_RS17440	COG5001	Diguanylate cyclase
BM524_RS17445	COG0784	Response regulator, receiver
BM524_RS17445	COG2205	protein histidine kinase activity
BM524_RS17455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BM524_RS17460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BM524_RS17465	COG1349	DNA-binding transcription factor activity
BM524_RS17470	COG0673	inositol 2-dehydrogenase activity
BM524_RS17485	COG0697	spore germination
BM524_RS17490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BM524_RS17495	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BM524_RS17500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BM524_RS17505	COG1166	arginine decarboxylase activity
BM524_RS17515	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BM524_RS17575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM524_RS17615	COG3030	protein affecting phage T7 exclusion by the F plasmid
BM524_RS17620	COG1324	tolerance protein
BM524_RS17625	COG4232	protein-disulfide reductase activity
BM524_RS17630	COG0739	heme binding
BM524_RS17635	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BM524_RS17640	COG0511	ligase activity, forming carbon-carbon bonds
BM524_RS17645	COG0439	Biotin carboxylase
BM524_RS17690	COG0154	amidase activity
BM524_RS17705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM524_RS17710	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BM524_RS17725	COG0151	Belongs to the GarS family
BM524_RS17745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM524_RS17750	COG3954	Phosphoribulokinase
BM524_RS17775	COG1501	Belongs to the glycosyl hydrolase 31 family
BM524_RS17780	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BM524_RS17785	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BM524_RS17795	COG3031	protein transport across the cell outer membrane
BM524_RS17805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BM524_RS17810	COG1459	type II secretion system
BM524_RS17815	COG2165	general secretion pathway protein
BM524_RS17820	COG2165	general secretion pathway protein
BM524_RS17825	COG2165	general secretion pathway protein
BM524_RS17830	COG4795	General secretion pathway protein
BM524_RS17845	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
BM524_RS17865	COG1012	belongs to the aldehyde dehydrogenase family
BM524_RS17875	COG1011	Hydrolase
BM524_RS17880	COG0494	nUDIX hydrolase
BM524_RS17885	COG1218	3'(2'),5'-bisphosphate nucleotidase
BM524_RS17895	COG2943	transferase activity, transferring hexosyl groups
BM524_RS17900	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BM524_RS17910	COG3089	Belongs to the UPF0270 family
BM524_RS17915	COG0429	hydrolase of the alpha beta-hydrolase fold
BM524_RS17925	COG0488	(ABC) transporter
BM524_RS17940	COG2900	Belongs to the SlyX family
BM524_RS17950	COG0545	Peptidyl-prolyl cis-trans isomerase
BM524_RS17960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BM524_RS17965	COG2183	response to ionizing radiation
BM524_RS17985	COG0596	Alpha beta hydrolase
BM524_RS17990	COG1040	competence protein
BM524_RS18010	COG1794	racemase activity, acting on amino acids and derivatives
BM524_RS18025	COG0534	Mate efflux family protein
BM524_RS18030	COG1649	PFAM Uncharacterised BCR, COG1649
BM524_RS18030	COG0726	polysaccharide deacetylase
BM524_RS18040	COG1999	signal sequence binding
BM524_RS18045	COG0109	protoheme IX farnesyltransferase activity
BM524_RS18050	COG1612	heme a metabolic process
BM524_RS18070	COG1845	cytochrome c oxidase, subunit III
BM524_RS18075	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BM524_RS18080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BM524_RS18085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BM524_RS18095	COG3706	GGDEF domain
BM524_RS18110	COG0129	dihydroxy-acid dehydratase activity
BM524_RS18120	COG0606	chelatase, subunit chli
BM524_RS18125	COG0583	DNA-binding transcription factor activity
BM524_RS18135	COG2814	Major facilitator Superfamily
BM524_RS18140	COG1073	alpha beta
BM524_RS18145	COG0729	surface antigen
BM524_RS18150	COG2911	Protein conserved in bacteria
BM524_RS18175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BM524_RS18185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BM524_RS18205	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM524_RS18230	COG1228	amidohydrolase
BM524_RS18255	COG0425	Belongs to the sulfur carrier protein TusA family
BM524_RS18270	COG1561	YicC-like family, N-terminal region
BM524_RS18330	COG2723	6-phospho-beta-galactosidase activity
BM524_RS18335	COG2211	Major facilitator Superfamily
BM524_RS18340	COG1609	Transcriptional regulator
BM524_RS18355	COG2199	diguanylate cyclase activity
BM524_RS18355	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BM524_RS18380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BM524_RS18400	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BM524_RS18405	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BM524_RS18425	COG1475	DNA binding
BM524_RS18430	COG1192	Involved in chromosome partitioning
BM524_RS18455	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BM524_RS18460	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BM524_RS18470	COG0706	membrane insertase activity
BM524_RS18475	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BM524_RS18480	COG0594	ribonuclease P activity
BM524_RS18485	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BM524_RS18930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM524_RS18950	COG0667	Aldo Keto reductase
BM524_RS19150	COG1132	(ABC) transporter
BM524_RS19165	COG1132	(ABC) transporter
BM524_RS19425	COG0181	hydroxymethylbilane synthase activity
BM524_RS19515	COG1178	ABC-type Fe3 transport system permease component
BM524_RS19615	COG0427	acetyl-CoA hydrolase
BM524_RS19635	COG0840	transmembrane signaling receptor activity
BM524_RS19645	COG3064	Membrane
BM524_RS19700	COG0514	ATP-dependent DNA helicase (RecQ)
BM524_RS19705	COG0514	ATP-dependent DNA helicase (RecQ)
BM524_RS20110	COG1792	Involved in formation and maintenance of cell shape
BM524_RS20220	COG0643	Histidine kinase
BM524_RS20220	COG2198	Histidine kinase
BM524_RS20735	COG1643	Atp-dependent helicase
BM524_RS21060	COG0281	malic enzyme
BM524_RS21245	COG0028	Belongs to the TPP enzyme family