locus-tag	class	description
MADE_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MADE_RS00020	COG0187	DNA topoisomerase II activity
MADE_RS00040	COG2818	Glycosylase
MADE_RS00050	COG3078	GTPase activator activity
MADE_RS00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MADE_RS00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MADE_RS00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
MADE_RS00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MADE_RS00085	COG0569	domain protein
MADE_RS00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MADE_RS00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MADE_RS00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MADE_RS00110	COG0758	DNA mediated transformation
MADE_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
MADE_RS00130	COG0408	coproporphyrinogen oxidase activity
MADE_RS00135	COG3047	cAMP biosynthetic process
MADE_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MADE_RS00180	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MADE_RS00225	COG2234	aminopeptidase activity
MADE_RS00230	COG0463	Glycosyl transferase, family 2
MADE_RS00240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MADE_RS00265	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MADE_RS00295	COG3642	lipopolysaccharide core region biosynthetic process
MADE_RS00300	COG0859	PFAM glycosyl transferase family 9
MADE_RS00330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MADE_RS00345	COG3161	chorismate lyase activity
MADE_RS00350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MADE_RS00370	COG0210	DNA helicase
MADE_RS00400	COG1757	Na H antiporter
MADE_RS00415	COG1959	2 iron, 2 sulfur cluster binding
MADE_RS00420	COG0730	response to heat
MADE_RS00435	COG4771	TonB-dependent receptor
MADE_RS00450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MADE_RS00455	COG4988	ABC transporter
MADE_RS00465	COG1271	oxidase subunit
MADE_RS00470	COG0425	Belongs to the sulfur carrier protein TusA family
MADE_RS00470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MADE_RS00480	COG0450	alkyl hydroperoxide reductase
MADE_RS00490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MADE_RS00520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MADE_RS00565	COG1196	nuclear chromosome segregation
MADE_RS00630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MADE_RS00640	COG0842	Transport permease protein
MADE_RS00655	COG1960	acyl-CoA dehydrogenase activity
MADE_RS00660	COG0583	DNA-binding transcription factor activity
MADE_RS00670	COG3106	COG3106 Predicted ATPase
MADE_RS00685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MADE_RS00705	COG0352	thiamine-phosphate diphosphorylase activity
MADE_RS00715	COG3071	HemY protein
MADE_RS00720	COG2959	enzyme of heme biosynthesis
MADE_RS00730	COG0181	hydroxymethylbilane synthase activity
MADE_RS00745	COG0194	GDP metabolic process
MADE_RS00755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MADE_RS00765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MADE_RS00770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MADE_RS00780	COG0678	peroxiredoxin activity
MADE_RS00795	COG1178	ABC-type Fe3 transport system permease component
MADE_RS00800	COG3842	ATPase activity
MADE_RS00805	COG0668	transmembrane transport
MADE_RS00810	COG2081	HI0933 family
MADE_RS00845	COG2200	EAL domain
MADE_RS00850	COG0583	DNA-binding transcription factor activity
MADE_RS00875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MADE_RS00890	COG0427	acetyl-CoA hydrolase
MADE_RS00895	COG0123	including yeast histone deacetylase and acetoin utilization protein
MADE_RS00910	COG0840	transmembrane signaling receptor activity
MADE_RS00920	COG3064	Membrane
MADE_RS00930	COG5001	Diguanylate cyclase
MADE_RS00930	COG5002	protein histidine kinase activity
MADE_RS00945	COG0514	ATP-dependent DNA helicase (RecQ)
MADE_RS00950	COG2239	Acts as a magnesium transporter
MADE_RS00955	COG2962	Rard protein
MADE_RS00965	COG0210	DNA helicase
MADE_RS00975	COG1011	Hydrolase
MADE_RS00980	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MADE_RS00990	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MADE_RS00995	COG0019	diaminopimelate decarboxylase activity
MADE_RS01025	COG0163	prenyltransferase activity
MADE_RS01030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MADE_RS01040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MADE_RS01060	COG1077	Cell shape determining protein MreB Mrl
MADE_RS01070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MADE_RS01075	COG2814	Major facilitator Superfamily
MADE_RS01080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MADE_RS01105	COG1085	galactose-1-phosphate uridylyltransferase
MADE_RS01110	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MADE_RS01125	COG0629	single-stranded DNA binding
MADE_RS01140	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MADE_RS01145	COG3250	beta-galactosidase activity
MADE_RS01165	COG1349	DNA-binding transcription factor activity
MADE_RS01210	COG3409	Peptidoglycan-binding domain 1 protein
MADE_RS01210	COG3267	Type II secretory pathway component ExeA
MADE_RS01220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MADE_RS01225	COG1459	type II secretion system
MADE_RS01235	COG2165	general secretion pathway protein
MADE_RS01240	COG2165	general secretion pathway protein
MADE_RS01245	COG2165	general secretion pathway protein
MADE_RS01270	COG1077	Cell shape determining protein MreB Mrl
MADE_RS01275	COG1792	Involved in formation and maintenance of cell shape
MADE_RS01280	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MADE_RS01290	COG1530	ribonuclease E activity
MADE_RS01300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MADE_RS01305	COG0312	modulator of DNA gyrase
MADE_RS01310	COG3028	Belongs to the UPF0307 family
MADE_RS01315	COG0312	modulator of DNA gyrase
MADE_RS01330	COG0745	RESPONSE REGULATOR receiver
MADE_RS01335	COG4191	Histidine kinase
MADE_RS01335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MADE_RS01340	COG0297	glycogen (starch) synthase activity
MADE_RS01350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MADE_RS01355	COG0596	Alpha beta hydrolase
MADE_RS01425	COG4974	Belongs to the 'phage' integrase family
MADE_RS01445	COG0758	DNA mediated transformation
MADE_RS01510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MADE_RS01515	COG5002	protein histidine kinase activity
MADE_RS01520	COG0745	RESPONSE REGULATOR receiver
MADE_RS01540	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MADE_RS01610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MADE_RS01610	COG1017	nitric oxide dioxygenase activity
MADE_RS01630	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MADE_RS01645	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
MADE_RS01660	COG0375	protein maturation
MADE_RS01670	COG0409	Hydrogenase expression formation protein
MADE_RS01680	COG0309	Hydrogenase expression formation protein (HypE)
MADE_RS01685	COG0789	Transcriptional regulator
MADE_RS01690	COG2217	Heavy metal translocating P-type atpase
MADE_RS01795	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MADE_RS01815	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MADE_RS01825	COG0463	Glycosyl transferase, family 2
MADE_RS01830	COG0745	RESPONSE REGULATOR receiver
MADE_RS01835	COG5002	protein histidine kinase activity
MADE_RS01865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MADE_RS01875	COG0789	Transcriptional regulator
MADE_RS01880	COG2217	Heavy metal translocating P-type atpase
MADE_RS01915	COG0531	amino acid
MADE_RS01955	COG0745	RESPONSE REGULATOR receiver
MADE_RS01965	COG0835	chemotaxis
MADE_RS01970	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MADE_RS02010	COG0546	phosphoglycolate phosphatase activity
MADE_RS02030	COG1609	Transcriptional regulator
MADE_RS02035	COG0673	inositol 2-dehydrogenase activity
MADE_RS02045	COG2211	Major facilitator Superfamily
MADE_RS02050	COG1082	Xylose isomerase domain protein TIM barrel
MADE_RS02070	COG1454	alcohol dehydrogenase
MADE_RS02115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MADE_RS02135	COG0089	rRNA binding
MADE_RS02145	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MADE_RS02155	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MADE_RS02170	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MADE_RS02185	COG3344	reverse transcriptase
MADE_RS02190	COG0438	transferase activity, transferring glycosyl groups
MADE_RS02200	COG1519	Transferase
MADE_RS02220	COG0840	transmembrane signaling receptor activity
MADE_RS02235	COG0788	formyltetrahydrofolate deformylase activity
MADE_RS02245	COG1643	Atp-dependent helicase
MADE_RS02250	COG2951	lytic endotransglycosylase activity
MADE_RS02255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MADE_RS02265	COG2354	Protein conserved in bacteria
MADE_RS02285	COG0004	ammonium transporteR
MADE_RS02290	COG0405	Gamma-glutamyltransferase
MADE_RS02295	COG2837	iron assimilation
MADE_RS02310	COG0540	Belongs to the ATCase OTCase family
MADE_RS02335	COG5002	protein histidine kinase activity
MADE_RS02335	COG0784	Response regulator, receiver
MADE_RS02335	COG2205	protein histidine kinase activity
MADE_RS02350	COG3300	MHYT domain
MADE_RS02350	COG5001	Diguanylate cyclase
MADE_RS02360	COG1012	belongs to the aldehyde dehydrogenase family
MADE_RS02370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MADE_RS02385	COG0180	Tryptophanyl-tRNA synthetase
MADE_RS02390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MADE_RS02410	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MADE_RS02420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MADE_RS02455	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MADE_RS02460	COG0281	malic enzyme
MADE_RS02470	COG0625	glutathione transferase activity
MADE_RS02480	COG0753	catalase activity
MADE_RS02495	COG3300	MHYT domain
MADE_RS02495	COG5001	Diguanylate cyclase
MADE_RS02500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MADE_RS02500	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MADE_RS02510	COG0137	argininosuccinate synthase activity
MADE_RS02530	COG1803	Methylglyoxal synthase
MADE_RS02540	COG0745	RESPONSE REGULATOR receiver
MADE_RS02545	COG2205	protein histidine kinase activity
MADE_RS02550	COG2267	carboxylic ester hydrolase activity
MADE_RS02555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MADE_RS02565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MADE_RS02575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MADE_RS02580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MADE_RS02585	COG4942	peptidase
MADE_RS02590	COG2861	carbohydrate metabolic process
MADE_RS02615	COG1162	GTPase activity
MADE_RS02620	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MADE_RS02655	COG0028	Belongs to the TPP enzyme family
MADE_RS02675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MADE_RS02680	COG0805	protein transport
MADE_RS02690	COG0084	hydrolase, TatD family'
MADE_RS02695	COG4251	negative regulation of phosphorylation
MADE_RS02695	COG5001	Diguanylate cyclase
MADE_RS02695	COG3706	GGDEF domain
MADE_RS02695	COG2203	Gaf domain
MADE_RS02705	COG0248	Ppx GppA phosphatase
MADE_RS02710	COG0513	Belongs to the DEAD box helicase family
MADE_RS02715	COG3118	belongs to the thioredoxin family
MADE_RS02720	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MADE_RS02725	COG1473	amidohydrolase
MADE_RS02730	COG5002	protein histidine kinase activity
MADE_RS02730	COG0784	Response regulator, receiver
MADE_RS02735	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MADE_RS02740	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MADE_RS02745	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MADE_RS02760	COG0783	Belongs to the Dps family
MADE_RS02765	COG2133	pyrroloquinoline quinone binding
MADE_RS02770	COG4946	Tricorn protease homolog
MADE_RS02770	COG0823	Involved in the tonB-independent uptake of proteins
MADE_RS02770	COG1506	peptidase
MADE_RS02780	COG3118	belongs to the thioredoxin family
MADE_RS02795	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
MADE_RS02805	COG1012	belongs to the aldehyde dehydrogenase family
MADE_RS02825	COG1757	Na H antiporter
MADE_RS02840	COG3876	Protein conserved in bacteria
MADE_RS02845	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MADE_RS02855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MADE_RS02890	COG2824	Alkylphosphonate utilization operon protein PhnA
MADE_RS02895	COG0454	-acetyltransferase
MADE_RS02925	COG3093	addiction module antidote protein HigA
MADE_RS02940	COG2026	Addiction module toxin, RelE StbE family
MADE_RS03030	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_RS03135	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_RS03175	COG0183	Belongs to the thiolase family
MADE_RS03180	COG1024	Enoyl-CoA hydratase
MADE_RS03180	COG1250	3-hydroxyacyl-CoA dehydrogenase
MADE_RS03190	COG0006	proline dipeptidase activity
MADE_RS03200	COG0142	geranyltranstransferase activity
MADE_RS03230	COG4942	peptidase
MADE_RS03230	COG1388	LysM domain
MADE_RS03235	COG1238	metal cluster binding
MADE_RS03245	COG0585	pseudouridine synthase activity
MADE_RS03250	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MADE_RS03260	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MADE_RS03270	COG0840	transmembrane signaling receptor activity
MADE_RS03305	COG0494	nUDIX hydrolase
MADE_RS03310	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
MADE_RS03315	COG0730	response to heat
MADE_RS03320	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MADE_RS03325	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MADE_RS03360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MADE_RS03370	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MADE_RS03380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MADE_RS03380	COG1648	precorrin-2 dehydrogenase activity
MADE_RS03385	COG0513	Belongs to the DEAD box helicase family
MADE_RS03400	COG1538	Outer membrane efflux protein
MADE_RS03405	COG0494	nUDIX hydrolase
MADE_RS03415	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MADE_RS03420	COG3150	esterase
MADE_RS03425	COG0187	DNA topoisomerase II activity
MADE_RS03435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MADE_RS03460	COG1509	lysine 2,3-aminomutase activity
MADE_RS03465	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MADE_RS03470	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MADE_RS03485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MADE_RS03500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MADE_RS03515	COG0271	Belongs to the BolA IbaG family
MADE_RS03530	COG3707	response regulator
MADE_RS03545	COG0659	secondary active sulfate transmembrane transporter activity
MADE_RS03550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MADE_RS03560	COG0243	molybdopterin cofactor binding
MADE_RS03565	COG1648	precorrin-2 dehydrogenase activity
MADE_RS03565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MADE_RS03570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MADE_RS03580	COG1116	anion transmembrane transporter activity
MADE_RS03580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MADE_RS03590	COG1116	anion transmembrane transporter activity
MADE_RS03605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MADE_RS03610	COG4206	TonB-dependent receptor
MADE_RS03620	COG0348	domain, Protein
MADE_RS03635	COG1960	acyl-CoA dehydrogenase activity
MADE_RS03640	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_RS03650	COG4948	Mandelate Racemase Muconate Lactonizing
MADE_RS03665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MADE_RS03670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MADE_RS03695	COG0358	DNA primase activity
MADE_RS03720	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MADE_RS03725	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MADE_RS03740	COG0537	adenosine 5'-monophosphoramidase activity
MADE_RS03755	COG3135	benzoate transporter
MADE_RS03760	COG1396	sequence-specific DNA binding
MADE_RS03765	COG2974	May be involved in recombination
MADE_RS03770	COG4191	Histidine kinase
MADE_RS03770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MADE_RS03775	COG0745	RESPONSE REGULATOR receiver
MADE_RS03780	COG5002	protein histidine kinase activity
MADE_RS03805	COG0811	peptide transport
MADE_RS03810	COG0811	peptide transport
MADE_RS03815	COG0848	biopolymer transport protein
MADE_RS03820	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
MADE_RS03830	COG3437	response regulator, receiver
MADE_RS03850	COG2133	pyrroloquinoline quinone binding
MADE_RS03860	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MADE_RS03885	COG0527	aspartate kinase activity
MADE_RS03890	COG0840	transmembrane signaling receptor activity
MADE_RS03895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MADE_RS03900	COG2967	ApaG domain
MADE_RS03910	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MADE_RS03915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MADE_RS03920	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MADE_RS03925	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MADE_RS03935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MADE_RS03955	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MADE_RS03970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MADE_RS03975	COG3956	TIGRFAM MazG family protein
MADE_RS04000	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_RS04010	COG0318	PFAM AMP-dependent synthetase and ligase
MADE_RS04020	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MADE_RS04030	COG0463	Glycosyl transferase, family 2
MADE_RS04065	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MADE_RS04070	COG0723	plastoquinol--plastocyanin reductase activity
MADE_RS04075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MADE_RS04080	COG2857	Cytochrome c1
MADE_RS04085	COG0625	glutathione transferase activity
MADE_RS04090	COG2969	positive regulation of protein catabolic process
MADE_RS04095	COG2239	Acts as a magnesium transporter
MADE_RS04100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MADE_RS04120	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MADE_RS04125	COG1137	ATPase activity
MADE_RS04130	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MADE_RS04140	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MADE_RS04155	COG1127	ABC transporter
MADE_RS04160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MADE_RS04165	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MADE_RS04170	COG2854	intermembrane phospholipid transfer
MADE_RS04180	COG5007	Belongs to the BolA IbaG family
MADE_RS04190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MADE_RS04195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MADE_RS04205	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MADE_RS04230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MADE_RS04240	COG4771	TonB-dependent receptor
MADE_RS04245	COG0697	spore germination
MADE_RS04255	COG0784	Response regulator, receiver
MADE_RS04255	COG2205	protein histidine kinase activity
MADE_RS04280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MADE_RS04290	COG0126	phosphoglycerate kinase activity
MADE_RS04295	COG3588	fructose-bisphosphate aldolase
MADE_RS04305	COG0823	Involved in the tonB-independent uptake of proteins
MADE_RS04305	COG1506	peptidase
MADE_RS04305	COG4946	Tricorn protease homolog
MADE_RS04310	COG0248	Ppx GppA phosphatase
MADE_RS04315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MADE_RS04325	COG0573	inorganic phosphate transmembrane transporter activity
MADE_RS04335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MADE_RS04345	COG0306	phosphate transporter
MADE_RS04355	COG0583	DNA-binding transcription factor activity
MADE_RS04365	COG1272	protein, Hemolysin III
MADE_RS04370	COG1846	Transcriptional regulator
MADE_RS04375	COG1764	response to oxidative stress
MADE_RS04390	COG1739	Uncharacterized protein family UPF0029
MADE_RS04400	COG0420	3'-5' exonuclease activity
MADE_RS04405	COG0419	ATPase involved in DNA repair
MADE_RS04415	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MADE_RS04430	COG2188	Transcriptional regulator
MADE_RS04440	COG2986	histidine ammonia-lyase
MADE_RS04465	COG0488	(ABC) transporter
MADE_RS04485	COG0668	transmembrane transport
MADE_RS04540	COG1346	cytolysis
MADE_RS04570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MADE_RS04580	COG0513	Belongs to the DEAD box helicase family
MADE_RS04590	COG3267	Type II secretory pathway component ExeA
MADE_RS04590	COG3409	Peptidoglycan-binding domain 1 protein
MADE_RS04605	COG0066	3-isopropylmalate dehydratase activity
MADE_RS04615	COG0473	3-isopropylmalate dehydrogenase activity
MADE_RS04620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MADE_RS04640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MADE_RS04655	COG4555	ABC transporter
MADE_RS04660	COG1668	transmembrane transport
MADE_RS04675	COG4133	protoheme IX ABC transporter activity
MADE_RS04680	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MADE_RS04685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MADE_RS04690	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MADE_RS04700	COG1138	Cytochrome C-type biogenesis protein
MADE_RS04705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MADE_RS04720	COG2853	Lipoprotein
MADE_RS04725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MADE_RS04765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MADE_RS04780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MADE_RS04785	COG1555	photosystem II stabilization
MADE_RS04785	COG1596	polysaccharide export
MADE_RS04790	COG0473	3-isopropylmalate dehydrogenase activity
MADE_RS04805	COG1611	Belongs to the LOG family
MADE_RS04815	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MADE_RS04815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MADE_RS04875	COG0024	Methionine aminopeptidase
MADE_RS04890	COG0528	UMP kinase activity
MADE_RS04905	COG0575	Belongs to the CDS family
MADE_RS04930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MADE_RS04950	COG0587	DNA-directed DNA polymerase activity
MADE_RS04955	COG0825	malonyl-CoA metabolic process
MADE_RS04960	COG0037	tRNA processing
MADE_RS04990	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MADE_RS04990	COG0047	phosphoribosylformylglycinamidine synthase activity
MADE_RS04995	COG2840	Smr protein MutS2
MADE_RS05020	COG1132	(ABC) transporter
MADE_RS05120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MADE_RS05125	COG0789	Transcriptional regulator
MADE_RS05150	COG0789	Transcriptional regulator
MADE_RS05190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MADE_RS05200	COG4644	lycopene metabolic process
MADE_RS05210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MADE_RS05215	COG2197	response regulator
MADE_RS05250	COG0784	Response regulator, receiver
MADE_RS05250	COG0835	chemotaxis
MADE_RS05255	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MADE_RS05260	COG1815	bacterial-type flagellum-dependent cell motility
MADE_RS05275	COG1749	Flagellar hook protein flgE
MADE_RS05280	COG4787	bacterial-type flagellum-dependent cell motility
MADE_RS05300	COG1705	Flagellar rod assembly protein muramidase FlgJ
MADE_RS05300	COG3951	Flagellar rod assembly protein muramidase FlgJ
MADE_RS05340	COG1516	flagellar protein fliS
MADE_RS05355	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MADE_RS05370	COG2089	acid synthase
MADE_RS05405	COG1083	cytidylyl-transferase
MADE_RS05410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MADE_RS05415	COG1086	Polysaccharide biosynthesis protein
MADE_RS05440	COG1677	Flagellar hook-basal body complex protein FliE
MADE_RS05445	COG1766	The M ring may be actively involved in energy transduction
MADE_RS05450	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MADE_RS05500	COG1987	bacterial-type flagellum assembly
MADE_RS05515	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MADE_RS05540	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MADE_RS05545	COG2198	Histidine kinase
MADE_RS05545	COG0784	Response regulator, receiver
MADE_RS05545	COG0643	Histidine kinase
MADE_RS05555	COG1192	Involved in chromosome partitioning
MADE_RS05565	COG0835	chemotaxis
MADE_RS05580	COG0646	methionine synthase
MADE_RS05580	COG1410	methionine synthase
MADE_RS05585	COG1410	methionine synthase
MADE_RS05585	COG0646	methionine synthase
MADE_RS05595	COG3123	guanosine phosphorylase activity
MADE_RS05600	COG0583	DNA-binding transcription factor activity
MADE_RS05605	COG0583	DNA-binding transcription factor activity
MADE_RS05615	COG0659	secondary active sulfate transmembrane transporter activity
MADE_RS05630	COG3590	peptidase
MADE_RS05640	COG2137	regulation of response to DNA damage stimulus
MADE_RS05645	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MADE_RS05670	COG0511	ligase activity, forming carbon-carbon bonds
MADE_RS05670	COG5016	pyruvate
MADE_RS05675	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MADE_RS05680	COG4172	Belongs to the ABC transporter superfamily
MADE_RS05690	COG4171	peptide transport system, permease
MADE_RS05695	COG4168	peptide transport system, permease
MADE_RS05700	COG0747	negative chemotaxis
MADE_RS05705	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MADE_RS05710	COG1842	Phage shock protein A
MADE_RS05740	COG0625	glutathione transferase activity
MADE_RS05745	COG1522	sequence-specific DNA binding
MADE_RS05805	COG0811	peptide transport
MADE_RS05810	COG0811	peptide transport
MADE_RS05815	COG0848	biopolymer transport protein
MADE_RS05835	COG1444	tRNA N-acetyltransferase activity
MADE_RS05875	COG0456	acetyltransferase
MADE_RS05890	COG0583	DNA-binding transcription factor activity
MADE_RS05900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MADE_RS05905	COG0656	L-ascorbic acid biosynthetic process
MADE_RS05925	COG1846	Transcriptional regulator
MADE_RS05940	COG3344	reverse transcriptase
MADE_RS05960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MADE_RS05995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MADE_RS05995	COG0543	2 iron, 2 sulfur cluster binding
MADE_RS06010	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MADE_RS06015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MADE_RS06020	COG0564	pseudouridine synthase activity
MADE_RS06030	COG0612	Peptidase, M16
MADE_RS06035	COG2918	glutathione biosynthetic process
MADE_RS06055	COG2840	Smr protein MutS2
MADE_RS06060	COG2890	protein-(glutamine-N5) methyltransferase activity
MADE_RS06075	COG2719	SpoVR family
MADE_RS06080	COG2718	Belongs to the UPF0229 family
MADE_RS06085	COG2766	serine protein kinase
MADE_RS06090	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MADE_RS06095	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MADE_RS06100	COG4771	TonB-dependent receptor
MADE_RS06125	COG0450	alkyl hydroperoxide reductase
MADE_RS06130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MADE_RS06135	COG2885	chlorophyll binding
MADE_RS06140	COG0584	glycerophosphoryl diester phosphodiesterase
MADE_RS06145	COG0346	lactoylglutathione lyase activity
MADE_RS06150	COG1278	Cold shock
MADE_RS06165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MADE_RS06170	COG4660	Part of a membrane complex involved in electron transport
MADE_RS06175	COG4659	FMN binding
MADE_RS06180	COG4658	electron transport chain
MADE_RS06185	COG4656	Part of a membrane complex involved in electron transport
MADE_RS06190	COG2878	Part of a membrane complex involved in electron transport
MADE_RS06195	COG4657	Part of a membrane complex involved in electron transport
MADE_RS06210	COG0534	Mate efflux family protein
MADE_RS06215	COG0556	nucleotide-excision repair
MADE_RS06230	COG0602	queuosine metabolic process
MADE_RS06240	COG0367	asparagine synthase
MADE_RS06265	COG3273	potassium ion transport
MADE_RS06265	COG0471	metal ion transport
MADE_RS06280	COG0529	Catalyzes the synthesis of activated sulfate
MADE_RS06285	COG0175	sulfate reduction
MADE_RS06290	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MADE_RS06295	COG2199	diguanylate cyclase activity
MADE_RS06295	COG2203	Gaf domain
MADE_RS06320	COG2304	oxidoreductase activity
MADE_RS06340	COG0714	Associated with various cellular activities
MADE_RS06350	COG1250	3-hydroxyacyl-CoA dehydrogenase
MADE_RS06350	COG1024	Enoyl-CoA hydratase
MADE_RS06365	COG1025	Belongs to the peptidase M16 family
MADE_RS06370	COG2062	phosphohistidine phosphatase, SixA
MADE_RS06385	COG4137	Cytochrome C assembly protein
MADE_RS06390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MADE_RS06440	COG1132	(ABC) transporter
MADE_RS06455	COG0228	four-way junction DNA binding
MADE_RS06460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MADE_RS06465	COG0336	Belongs to the RNA methyltransferase TrmD family
MADE_RS06470	COG0335	large ribosomal subunit rRNA binding
MADE_RS06475	COG2860	membrane
MADE_RS06485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MADE_RS06490	COG1605	Chorismate mutase
MADE_RS06490	COG0287	Prephenate dehydrogenase
MADE_RS06495	COG1605	Chorismate mutase
MADE_RS06495	COG0077	Prephenate dehydratase
MADE_RS06505	COG0023	Translation Initiation Factor
MADE_RS06535	COG2205	protein histidine kinase activity
MADE_RS06545	COG2204	response regulator
MADE_RS06565	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MADE_RS06570	COG0494	nUDIX hydrolase
MADE_RS06575	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MADE_RS06580	COG0632	four-way junction helicase activity
MADE_RS06585	COG2255	four-way junction helicase activity
MADE_RS06590	COG0824	Thioesterase
MADE_RS06595	COG0811	peptide transport
MADE_RS06610	COG0823	Involved in the tonB-independent uptake of proteins
MADE_RS06615	COG2885	chlorophyll binding
MADE_RS06625	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MADE_RS06640	COG4667	esterase of the alpha-beta hydrolase superfamily
MADE_RS06645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MADE_RS06655	COG0784	Response regulator, receiver
MADE_RS06655	COG2205	protein histidine kinase activity
MADE_RS06670	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
MADE_RS06675	COG3038	cytochrome b561
MADE_RS06700	COG1451	nucleotide metabolic process
MADE_RS06710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MADE_RS06720	COG1309	transcriptional regulator
MADE_RS06725	COG4774	siderophore transport
MADE_RS06745	COG3706	GGDEF domain
MADE_RS06755	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MADE_RS06755	COG3008	intermembrane lipid transfer
MADE_RS06760	COG2995	paraquat-inducible protein a
MADE_RS06775	COG0017	Asparaginyl-tRNA synthetase
MADE_RS06790	COG0189	ligase activity
MADE_RS06820	COG0156	8-amino-7-oxononanoate synthase activity
MADE_RS06825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MADE_RS06835	COG3340	Belongs to the peptidase S51 family
MADE_RS06840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MADE_RS06845	COG4139	cobalamin transport
MADE_RS06850	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MADE_RS06855	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MADE_RS06870	COG5265	(ABC) transporter
MADE_RS06875	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MADE_RS06885	COG0745	RESPONSE REGULATOR receiver
MADE_RS06945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MADE_RS06960	COG2755	lipolytic protein G-D-S-L family
MADE_RS06965	COG4181	ATPase activity
MADE_RS06970	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MADE_RS06975	COG1090	epimerase
MADE_RS06980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MADE_RS06985	COG0628	permease
MADE_RS07010	COG2350	Protein conserved in bacteria
MADE_RS07015	COG0159	tryptophan synthase activity
MADE_RS07025	COG0135	phosphoribosylanthranilate isomerase activity
MADE_RS07025	COG0134	indole-3-glycerol-phosphate synthase activity
MADE_RS07030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MADE_RS07040	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MADE_RS07045	COG0613	PHP domain protein
MADE_RS07050	COG0009	L-threonylcarbamoyladenylate synthase
MADE_RS07060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MADE_RS07070	COG0656	L-ascorbic acid biosynthetic process
MADE_RS07075	COG0110	maltose O-acetyltransferase activity
MADE_RS07085	COG2733	membrane
MADE_RS07105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MADE_RS07110	COG0500	methyltransferase
MADE_RS07115	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MADE_RS07120	COG0497	DNA recombination
MADE_RS07125	COG0783	Belongs to the Dps family
MADE_RS07130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MADE_RS07135	COG1454	alcohol dehydrogenase
MADE_RS07140	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_RS07150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MADE_RS07155	COG2610	gluconate transmembrane transporter activity
MADE_RS07160	COG4771	TonB-dependent receptor
MADE_RS07185	COG2205	protein histidine kinase activity
MADE_RS07185	COG2202	Pas domain
MADE_RS07190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MADE_RS07200	COG0484	heat shock protein binding
MADE_RS07205	COG3909	cytochrome
MADE_RS07210	COG4943	cyclic-guanylate-specific phosphodiesterase activity
MADE_RS07225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MADE_RS07235	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MADE_RS07240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MADE_RS07265	COG0280	phosphate acetyltransferase
MADE_RS07265	COG0857	belongs to the CobB CobQ family
MADE_RS07280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MADE_RS07285	COG4535	Mg2 and Co2 transporter CorC
MADE_RS07295	COG1702	phosphate starvation-inducible protein PhoH
MADE_RS07305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MADE_RS07335	COG1607	acyl-coa hydrolase
MADE_RS07340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MADE_RS07350	COG1115	amino acid carrier protein
MADE_RS07400	COG0012	GTP binding
MADE_RS07415	COG1064	alcohol dehydrogenase
MADE_RS07430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MADE_RS07440	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MADE_RS07445	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MADE_RS07450	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MADE_RS07460	COG2890	protein-(glutamine-N5) methyltransferase activity
MADE_RS07465	COG0784	Response regulator, receiver
MADE_RS07465	COG3437	response regulator, receiver
MADE_RS07475	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MADE_RS07485	COG0583	DNA-binding transcription factor activity
MADE_RS07495	COG2363	Small membrane protein
MADE_RS07510	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
MADE_RS07515	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
MADE_RS07520	COG0515	serine threonine protein kinase
MADE_RS07525	COG2116	formate transmembrane transporter activity
MADE_RS07540	COG0714	Associated with various cellular activities
MADE_RS07545	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
MADE_RS07550	COG0033	Phosphoglucomutase
MADE_RS07555	COG0058	SHG alpha-glucan phosphorylase activity
MADE_RS07565	COG2988	succinylglutamate desuccinylase activity
MADE_RS07600	COG1393	Belongs to the ArsC family
MADE_RS07625	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MADE_RS07655	COG5001	Diguanylate cyclase
MADE_RS07655	COG3300	MHYT domain
MADE_RS07685	COG2249	NAD(P)H dehydrogenase (quinone) activity
MADE_RS07705	COG1733	regulation of RNA biosynthetic process
MADE_RS07710	COG5001	Diguanylate cyclase
MADE_RS07710	COG3447	MASE1 domain protein
MADE_RS07710	COG5002	protein histidine kinase activity
MADE_RS07720	COG0402	S-adenosylhomocysteine deaminase activity
MADE_RS07725	COG2351	hydroxyisourate hydrolase activity
MADE_RS07740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MADE_RS07755	COG1309	transcriptional regulator
MADE_RS07770	COG2252	PERMEase
MADE_RS07775	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MADE_RS07790	COG2203	Gaf domain
MADE_RS07790	COG5001	Diguanylate cyclase
MADE_RS07790	COG4251	negative regulation of phosphorylation
MADE_RS07790	COG3706	GGDEF domain
MADE_RS07800	COG2205	protein histidine kinase activity
MADE_RS07800	COG0784	Response regulator, receiver
MADE_RS07810	COG2233	PERMEase
MADE_RS07825	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MADE_RS07830	COG0730	response to heat
MADE_RS07870	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_RS07875	COG3001	Fructosamine kinase
MADE_RS07885	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MADE_RS07900	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MADE_RS07900	COG0662	Cupin 2, conserved barrel domain protein
MADE_RS07905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MADE_RS07915	COG1596	polysaccharide export
MADE_RS07920	COG0489	protein tyrosine kinase activity
MADE_RS07925	COG4464	protein tyrosine phosphatase activity
MADE_RS07950	COG5001	Diguanylate cyclase
MADE_RS07950	COG3300	MHYT domain
MADE_RS07975	COG1215	transferase activity, transferring glycosyl groups
MADE_RS07985	COG2244	polysaccharide biosynthetic process
MADE_RS08010	COG0438	transferase activity, transferring glycosyl groups
MADE_RS08015	COG1484	DNA-dependent DNA replication
MADE_RS08020	COG4584	PFAM Integrase catalytic
MADE_RS08035	COG3039	Transposase
MADE_RS08040	COG2755	lipolytic protein G-D-S-L family
MADE_RS08040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MADE_RS08060	COG0297	glycogen (starch) synthase activity
MADE_RS08075	COG0072	phenylalanine-tRNA ligase activity
MADE_RS08075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MADE_RS08100	COG1472	Belongs to the glycosyl hydrolase 3 family
MADE_RS08105	COG2096	Adenosyltransferase
MADE_RS08115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MADE_RS08125	COG4591	ABC-type transport system involved in lipoprotein release permease component
MADE_RS08150	COG0708	Exodeoxyribonuclease III
MADE_RS08185	COG2814	Major facilitator Superfamily
MADE_RS08220	COG4770	biotin carboxylase activity
MADE_RS08225	COG1024	Enoyl-CoA hydratase
MADE_RS08230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MADE_RS08235	COG1960	acyl-CoA dehydrogenase activity
MADE_RS08240	COG0789	Transcriptional regulator
MADE_RS08245	COG0183	Belongs to the thiolase family
MADE_RS08260	COG3706	GGDEF domain
MADE_RS08270	COG2925	Exonuclease
MADE_RS08320	COG1643	Atp-dependent helicase
MADE_RS08340	COG0604	alcohol dehydrogenase
MADE_RS08340	COG3321	synthase
MADE_RS08345	COG0328	RNA-DNA hybrid ribonuclease activity
MADE_RS08350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MADE_RS08375	COG4943	cyclic-guanylate-specific phosphodiesterase activity
MADE_RS08380	COG1136	(ABC) transporter
MADE_RS08385	COG4591	ABC-type transport system involved in lipoprotein release permease component
MADE_RS08400	COG3724	N-succinylarginine dihydrolase activity
MADE_RS08410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MADE_RS08425	COG0746	molybdenum cofactor guanylyltransferase activity
MADE_RS08430	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MADE_RS08435	COG0243	molybdopterin cofactor binding
MADE_RS08440	COG2153	protein acetylation
MADE_RS08455	COG1530	ribonuclease E activity
MADE_RS08460	COG0564	pseudouridine synthase activity
MADE_RS08470	COG0424	maF-like protein
MADE_RS08475	COG1399	metal-binding, possibly nucleic acid-binding protein
MADE_RS08495	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MADE_RS08505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MADE_RS08510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MADE_RS08520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MADE_RS08535	COG0084	hydrolase, TatD family'
MADE_RS08545	COG0702	epimerase
MADE_RS08550	COG3706	GGDEF domain
MADE_RS08570	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_RS08575	COG0596	Alpha beta hydrolase
MADE_RS08585	COG0183	Belongs to the thiolase family
MADE_RS08590	COG1960	acyl-CoA dehydrogenase activity
MADE_RS08610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MADE_RS08620	COG0246	Mannitol dehydrogenase
MADE_RS08625	COG3039	Transposase
MADE_RS08645	COG0668	transmembrane transport
MADE_RS08650	COG4771	TonB-dependent receptor
MADE_RS08680	COG3437	response regulator, receiver
MADE_RS08690	COG0195	Participates in both transcription termination and antitermination
MADE_RS08705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MADE_RS08720	COG1187	pseudouridine synthase activity
MADE_RS08730	COG3153	acetyltransferase
MADE_RS08730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MADE_RS08805	COG1032	radical SAM domain protein
MADE_RS08820	COG4771	TonB-dependent receptor
MADE_RS08825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MADE_RS08835	COG4134	Bacterial extracellular solute-binding protein
MADE_RS08845	COG4136	ATPase activity
MADE_RS08850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MADE_RS08875	COG4251	negative regulation of phosphorylation
MADE_RS08875	COG2203	Gaf domain
MADE_RS08875	COG3706	GGDEF domain
MADE_RS08875	COG5001	Diguanylate cyclase
MADE_RS08915	COG1131	(ABC) transporter
MADE_RS08920	COG1902	pentaerythritol trinitrate reductase activity
MADE_RS08930	COG2867	negative regulation of translational initiation
MADE_RS08935	COG2914	Belongs to the UPF0125 (RnfH) family
MADE_RS08945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MADE_RS08950	COG4771	TonB-dependent receptor
MADE_RS08955	COG0457	Tetratricopeptide repeat
MADE_RS08970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MADE_RS08970	COG0574	Belongs to the PEP-utilizing enzyme family
MADE_RS08980	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_RS09015	COG2850	peptidyl-arginine hydroxylation
MADE_RS09025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MADE_RS09030	COG2915	High frequency lysogenization protein hflD homolog
MADE_RS09035	COG0482	sulfurtransferase activity
MADE_RS09040	COG1187	pseudouridine synthase activity
MADE_RS09050	COG1278	Cold shock
MADE_RS09055	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MADE_RS09065	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MADE_RS09070	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MADE_RS09075	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MADE_RS09080	COG0492	ferredoxin-NADP+ reductase activity
MADE_RS09090	COG3091	SprT-like family
MADE_RS09095	COG0616	signal peptide processing
MADE_RS09110	COG0778	Nitroreductase
MADE_RS09120	COG0252	asparaginase activity
MADE_RS09125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MADE_RS09130	COG0321	lipoyl(octanoyl) transferase activity
MADE_RS09135	COG2921	Belongs to the UPF0250 family
MADE_RS09140	COG1686	Belongs to the peptidase S11 family
MADE_RS09145	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MADE_RS09150	COG0772	Belongs to the SEDS family
MADE_RS09155	COG0768	penicillin binding
MADE_RS09160	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MADE_RS09165	COG0799	negative regulation of ribosome biogenesis
MADE_RS09175	COG1466	dna polymerase III delta subunit
MADE_RS09180	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
MADE_RS09185	COG0495	leucyl-tRNA aminoacylation
MADE_RS09195	COG1067	ATP-dependent peptidase activity
MADE_RS09200	COG0596	Alpha beta hydrolase
MADE_RS09205	COG3706	GGDEF domain
MADE_RS09215	COG1534	Rna-binding protein
MADE_RS09225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MADE_RS09235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MADE_RS09240	COG0149	triose-phosphate isomerase activity
MADE_RS09245	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MADE_RS09255	COG3300	MHYT domain
MADE_RS09255	COG5001	Diguanylate cyclase
MADE_RS09275	COG1803	Methylglyoxal synthase
MADE_RS09275	COG1597	lipid kinase activity
MADE_RS09285	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_RS09290	COG0561	phosphatase activity
MADE_RS09305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MADE_RS09310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MADE_RS09315	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MADE_RS09360	COG2226	methyltransferase
MADE_RS09375	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_RS09480	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
MADE_RS09485	COG1196	nuclear chromosome segregation
MADE_RS09510	COG1132	(ABC) transporter
MADE_RS09515	COG1663	tetraacyldisaccharide 4'-kinase activity
MADE_RS09550	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MADE_RS09555	COG0435	Glutathione S-transferase
MADE_RS09560	COG1741	Belongs to the pirin family
MADE_RS09565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MADE_RS09575	COG0372	Belongs to the citrate synthase family
MADE_RS09585	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MADE_RS09590	COG1053	succinate dehydrogenase
MADE_RS09595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MADE_RS09600	COG0567	Dehydrogenase, E1 component
MADE_RS09605	COG0508	dehydrogenase complex catalyzes the overall conversion of
MADE_RS09640	COG4667	esterase of the alpha-beta hydrolase superfamily
MADE_RS09660	COG0366	Alpha amylase catalytic
MADE_RS09685	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_RS09690	COG2267	carboxylic ester hydrolase activity
MADE_RS09700	COG0616	signal peptide processing
MADE_RS09720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MADE_RS09725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MADE_RS09730	COG0386	Belongs to the glutathione peroxidase family
MADE_RS09735	COG2084	Dehydrogenase
MADE_RS09745	COG1960	acyl-CoA dehydrogenase activity
MADE_RS09750	COG1024	Enoyl-CoA hydratase
MADE_RS09755	COG2226	methyltransferase
MADE_RS09765	COG3083	sulfuric ester hydrolase activity
MADE_RS09770	COG3082	Protein of unknown function (DUF1414)
MADE_RS09775	COG3081	Nucleoid-associated protein
MADE_RS09805	COG3275	phosphorelay sensor kinase activity
MADE_RS09810	COG3279	Response regulator of the LytR AlgR family
MADE_RS09815	COG0205	6-phosphofructokinase activity
MADE_RS09835	COG5433	transposase activity
MADE_RS09850	COG3321	synthase
MADE_RS09850	COG0604	alcohol dehydrogenase
MADE_RS09850	COG4221	oxidoreductase activity
MADE_RS09850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MADE_RS09855	COG4221	oxidoreductase activity
MADE_RS09860	COG0583	DNA-binding transcription factor activity
MADE_RS09900	COG2205	protein histidine kinase activity
MADE_RS09900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MADE_RS09910	COG1054	Belongs to the UPF0176 family
MADE_RS09920	COG0513	Belongs to the DEAD box helicase family
MADE_RS09930	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MADE_RS09935	COG0583	DNA-binding transcription factor activity
MADE_RS09980	COG1322	Protein conserved in bacteria
MADE_RS09985	COG1404	Belongs to the peptidase S8 family
MADE_RS09995	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MADE_RS10000	COG0022	dehydrogenase e1 component
MADE_RS10010	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MADE_RS10015	COG0515	serine threonine protein kinase
MADE_RS10030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MADE_RS10040	COG1956	GAF domain-containing protein
MADE_RS10055	COG0793	Belongs to the peptidase S41A family
MADE_RS10060	COG0733	neurotransmitter:sodium symporter activity
MADE_RS10065	COG1757	Na H antiporter
MADE_RS10070	COG0308	aminopeptidase N
MADE_RS10100	COG2902	Dehydrogenase
MADE_RS10105	COG0167	dihydroorotate dehydrogenase activity
MADE_RS10120	COG0488	(ABC) transporter
MADE_RS10130	COG3130	regulation of translation
MADE_RS10135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MADE_RS10150	COG0415	Belongs to the DNA photolyase family
MADE_RS10160	COG0415	Belongs to the DNA photolyase family
MADE_RS10165	COG3046	protein related to deoxyribodipyrimidine photolyase
MADE_RS10240	COG4772	TonB-dependent receptor
MADE_RS10290	COG4974	Belongs to the 'phage' integrase family
MADE_RS10300	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MADE_RS10315	COG0069	glutamate synthase activity
MADE_RS10330	COG2193	ferroxidase activity
MADE_RS10340	COG3278	Belongs to the heme-copper respiratory oxidase family
MADE_RS10365	COG2217	Heavy metal translocating P-type atpase
MADE_RS10380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MADE_RS10385	COG0589	response to stress
MADE_RS10390	COG0037	tRNA processing
MADE_RS10395	COG1752	Esterase of the alpha-beta hydrolase superfamily
MADE_RS10415	COG1280	lysine exporter protein (LysE YggA)
MADE_RS10425	COG2897	thiosulfate sulfurtransferase activity
MADE_RS10430	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MADE_RS10435	COG3148	PFAM DTW domain containing protein
MADE_RS10485	COG0582	viral genome integration into host DNA
MADE_RS10510	COG0322	excinuclease ABC activity
MADE_RS10515	COG2197	response regulator
MADE_RS10520	COG0436	Aminotransferase
MADE_RS10540	COG2259	Doxx family
MADE_RS10545	COG0583	DNA-binding transcription factor activity
MADE_RS10560	COG0670	Belongs to the BI1 family
MADE_RS10580	COG2920	part of a sulfur-relay system
MADE_RS10610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MADE_RS10630	COG0686	Belongs to the AlaDH PNT family
MADE_RS10635	COG0284	orotidine-5'-phosphate decarboxylase activity
MADE_RS10640	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MADE_RS10665	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MADE_RS10670	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MADE_RS10675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MADE_RS10685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MADE_RS10690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MADE_RS10695	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MADE_RS10700	COG0633	Ferredoxin
MADE_RS10735	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MADE_RS10750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MADE_RS10760	COG4783	chaperone-mediated protein folding
MADE_RS10770	COG1393	Belongs to the ArsC family
MADE_RS10785	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MADE_RS10800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MADE_RS10810	COG1960	acyl-CoA dehydrogenase activity
MADE_RS10835	COG0572	uridine kinase
MADE_RS10840	COG3769	mannosylglycerate metabolic process
MADE_RS10845	COG1215	transferase activity, transferring glycosyl groups
MADE_RS10850	COG0366	Alpha amylase catalytic
MADE_RS10865	COG0534	Mate efflux family protein
MADE_RS10880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MADE_RS10885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MADE_RS10925	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_RS10945	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
MADE_RS10990	COG0405	Gamma-glutamyltransferase
MADE_RS10995	COG1024	Enoyl-CoA hydratase
MADE_RS11050	COG1448	Aminotransferase
MADE_RS11060	COG1671	Belongs to the UPF0178 family
MADE_RS11065	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_RS11070	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_RS11075	COG1960	acyl-CoA dehydrogenase activity
MADE_RS11080	COG2207	Transcriptional regulator
MADE_RS11080	COG0662	Cupin 2, conserved barrel domain protein
MADE_RS11095	COG1505	serine-type exopeptidase activity
MADE_RS11105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MADE_RS11140	COG0596	Alpha beta hydrolase
MADE_RS11150	COG0716	FMN binding
MADE_RS11160	COG0735	belongs to the Fur family
MADE_RS11170	COG1984	allophanate hydrolase subunit 2
MADE_RS11175	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MADE_RS11180	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MADE_RS11185	COG2996	Protein conserved in bacteria
MADE_RS11190	COG1765	OsmC-like protein
MADE_RS11195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MADE_RS11220	COG0436	Aminotransferase
MADE_RS11225	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MADE_RS11230	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MADE_RS11255	COG3012	SEC-C Motif Domain Protein
MADE_RS11260	COG0604	alcohol dehydrogenase
MADE_RS11270	COG1960	acyl-CoA dehydrogenase activity
MADE_RS11280	COG4771	TonB-dependent receptor
MADE_RS11305	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MADE_RS11325	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MADE_RS11335	COG0521	Mo-molybdopterin cofactor biosynthetic process
MADE_RS11340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MADE_RS11350	COG2161	toxin-antitoxin pair type II binding
MADE_RS11355	COG4115	mRNA cleavage
MADE_RS11370	COG0436	Aminotransferase
MADE_RS11375	COG3268	Saccharopine dehydrogenase
MADE_RS11380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MADE_RS11395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MADE_RS11400	COG4206	TonB-dependent receptor
MADE_RS11410	COG5006	permease, DMT superfamily
MADE_RS11425	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MADE_RS11430	COG1074	ATP-dependent DNA helicase activity
MADE_RS11435	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MADE_RS11445	COG1022	Amp-dependent synthetase and ligase
MADE_RS11450	COG5001	Diguanylate cyclase
MADE_RS11450	COG2203	Gaf domain
MADE_RS11450	COG3706	GGDEF domain
MADE_RS11450	COG4251	negative regulation of phosphorylation
MADE_RS11470	COG0583	DNA-binding transcription factor activity
MADE_RS11485	COG0640	Transcriptional regulator
MADE_RS11505	COG2204	response regulator
MADE_RS11515	COG4251	negative regulation of phosphorylation
MADE_RS11520	COG0784	Response regulator, receiver
MADE_RS11525	COG2205	protein histidine kinase activity
MADE_RS11525	COG0784	Response regulator, receiver
MADE_RS11550	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MADE_RS11575	COG3139	Protein of unknown function (DUF1315)
MADE_RS11590	COG1115	amino acid carrier protein
MADE_RS11595	COG2866	Carboxypeptidase
MADE_RS11615	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MADE_RS11625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MADE_RS11630	COG1640	4-alpha-glucanotransferase
MADE_RS11635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MADE_RS11640	COG0676	glucose-6-phosphate 1-epimerase activity
MADE_RS11645	COG0800	Aldolase
MADE_RS11655	COG0129	dihydroxy-acid dehydratase activity
MADE_RS11665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MADE_RS11670	COG1737	Transcriptional regulator
MADE_RS11675	COG0469	pyruvate kinase activity
MADE_RS11680	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MADE_RS11695	COG2823	Periplasmic or secreted lipoprotein
MADE_RS11725	COG3665	Urea carboxylase-associated protein
MADE_RS11760	COG2356	endonuclease I
MADE_RS11765	COG0840	transmembrane signaling receptor activity
MADE_RS11780	COG0583	DNA-binding transcription factor activity
MADE_RS11785	COG1979	alcohol dehydrogenase
MADE_RS11800	COG0784	Response regulator, receiver
MADE_RS11800	COG3437	response regulator, receiver
MADE_RS11840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MADE_RS11860	COG0471	metal ion transport
MADE_RS11870	COG0489	protein tyrosine kinase activity
MADE_RS11875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MADE_RS11875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MADE_RS11880	COG0668	transmembrane transport
MADE_RS11885	COG2226	methyltransferase
MADE_RS11890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MADE_RS11895	COG0741	lytic transglycosylase activity
MADE_RS11895	COG1388	LysM domain
MADE_RS11920	COG0215	cysteine-tRNA ligase activity
MADE_RS11925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MADE_RS11930	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MADE_RS11940	COG2268	Band 7 protein
MADE_RS11955	COG1733	regulation of RNA biosynthetic process
MADE_RS11960	COG0604	alcohol dehydrogenase
MADE_RS11970	COG0753	catalase activity
MADE_RS11975	COG0604	alcohol dehydrogenase
MADE_RS12005	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MADE_RS12015	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
MADE_RS12020	COG0285	dihydrofolate synthase activity
MADE_RS12045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MADE_RS12050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MADE_RS12070	COG3609	addiction module antidote protein, CC2985 family
MADE_RS12080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MADE_RS12085	COG0318	PFAM AMP-dependent synthetase and ligase
MADE_RS12095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MADE_RS12095	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MADE_RS12130	COG0789	Transcriptional regulator
MADE_RS12135	COG0604	alcohol dehydrogenase
MADE_RS12140	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_RS12160	COG1119	ATPase activity
MADE_RS12165	COG2031	fatty acid transporter
MADE_RS12170	COG0784	Response regulator, receiver
MADE_RS12170	COG2205	protein histidine kinase activity
MADE_RS12170	COG5002	protein histidine kinase activity
MADE_RS12180	COG0612	Peptidase, M16
MADE_RS12195	COG3101	peptidyl-lysine hydroxylation
MADE_RS12225	COG0446	pyridine nucleotide-disulphide oxidoreductase
MADE_RS12225	COG1902	pentaerythritol trinitrate reductase activity
MADE_RS12260	COG4399	Belongs to the UPF0754 family
MADE_RS12290	COG1770	oligopeptidase
MADE_RS12295	COG2186	Transcriptional regulator
MADE_RS12305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MADE_RS12310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MADE_RS12320	COG2983	Belongs to the UPF0260 family
MADE_RS12325	COG0179	Fumarylacetoacetate (FAA) hydrolase
MADE_RS12340	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MADE_RS12345	COG0318	PFAM AMP-dependent synthetase and ligase
MADE_RS12350	COG2267	carboxylic ester hydrolase activity
MADE_RS12365	COG1214	PFAM Peptidase M22, glycoprotease
MADE_RS12370	COG1199	ATP-dependent helicase activity
MADE_RS12420	COG4771	TonB-dependent receptor
MADE_RS12430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MADE_RS12435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MADE_RS12440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MADE_RS12445	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MADE_RS12445	COG0131	Imidazoleglycerol-phosphate dehydratase
MADE_RS12450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MADE_RS12465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MADE_RS12465	COG0140	phosphoribosyl-ATP diphosphatase activity
MADE_RS12470	COG2116	formate transmembrane transporter activity
MADE_RS12475	COG0840	transmembrane signaling receptor activity
MADE_RS12500	COG0326	Molecular chaperone. Has ATPase activity
MADE_RS12505	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MADE_RS12530	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MADE_RS12535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MADE_RS12545	COG3220	belongs to the UPF0276 family
MADE_RS12555	COG1136	(ABC) transporter
MADE_RS12555	COG0577	efflux transmembrane transporter activity
MADE_RS12565	COG3706	GGDEF domain
MADE_RS12565	COG4251	negative regulation of phosphorylation
MADE_RS12565	COG2203	Gaf domain
MADE_RS12565	COG5001	Diguanylate cyclase
MADE_RS12595	COG1183	phosphatidylcholine synthase activity
MADE_RS12615	COG0277	FAD linked oxidase domain protein
MADE_RS12620	COG0542	response to heat
MADE_RS12645	COG1595	DNA-templated transcription, initiation
MADE_RS12660	COG4221	oxidoreductase activity
MADE_RS12675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MADE_RS12685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MADE_RS12695	COG0142	geranyltranstransferase activity
MADE_RS12705	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MADE_RS12710	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MADE_RS12720	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MADE_RS12735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MADE_RS12735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MADE_RS12750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MADE_RS12755	COG0488	(ABC) transporter
MADE_RS12765	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MADE_RS12775	COG0560	Phosphoserine phosphatase
MADE_RS12785	COG0084	hydrolase, TatD family'
MADE_RS12800	COG0571	ribonuclease III activity
MADE_RS12830	COG1595	DNA-templated transcription, initiation
MADE_RS12835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MADE_RS12850	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MADE_RS12930	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MADE_RS12935	COG1047	Peptidyl-prolyl cis-trans
MADE_RS12945	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MADE_RS12950	COG0196	riboflavin kinase activity
MADE_RS12955	COG0728	peptidoglycan biosynthetic process
MADE_RS12960	COG0268	Binds directly to 16S ribosomal RNA
MADE_RS12975	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_RS12980	COG0385	Bile acid
MADE_RS13010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MADE_RS13015	COG0776	regulation of translation
MADE_RS13020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MADE_RS13025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MADE_RS13030	COG0740	serine-type endopeptidase activity
MADE_RS13035	COG0544	peptidyl-prolyl cis-trans isomerase activity
MADE_RS13075	COG1720	tRNA m6t6A37 methyltransferase activity
MADE_RS13085	COG1234	tRNA 3'-trailer cleavage
MADE_RS13120	COG0517	IMP dehydrogenase activity
MADE_RS13120	COG0516	GMP reductase activity
MADE_RS13125	COG1570	exodeoxyribonuclease VII activity
MADE_RS13145	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MADE_RS13150	COG2976	Protein conserved in bacteria
MADE_RS13175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MADE_RS13180	COG3344	reverse transcriptase
MADE_RS13195	COG2166	iron-sulfur cluster assembly
MADE_RS13210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MADE_RS13215	COG0719	Fe-S assembly protein
MADE_RS13220	COG0396	ATPase activity
MADE_RS13225	COG0719	Fe-S assembly protein
MADE_RS13230	COG1104	cysteine desulfurase activity
MADE_RS13240	COG2072	flavoprotein involved in K transport
MADE_RS13245	COG1045	serine acetyltransferase
MADE_RS13250	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MADE_RS13255	COG0483	inositol monophosphate 1-phosphatase activity
MADE_RS13270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MADE_RS13275	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MADE_RS13280	COG1862	Preprotein translocase
MADE_RS13285	COG0343	queuine tRNA-ribosyltransferase activity
MADE_RS13305	COG1842	Phage shock protein A
MADE_RS13310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MADE_RS13330	COG0754	glutathionylspermidine amidase activity
MADE_RS13360	COG2066	Belongs to the glutaminase family
MADE_RS13365	COG1785	Belongs to the alkaline phosphatase family
MADE_RS13370	COG0745	RESPONSE REGULATOR receiver
MADE_RS13480	COG0367	asparagine synthase
MADE_RS13500	COG0438	transferase activity, transferring glycosyl groups
MADE_RS13535	COG2246	polysaccharide biosynthetic process
MADE_RS13550	COG4372	Transposase
MADE_RS13555	COG2755	lipolytic protein G-D-S-L family
MADE_RS13555	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MADE_RS13595	COG2244	polysaccharide biosynthetic process
MADE_RS13615	COG0463	Glycosyl transferase, family 2
MADE_RS13620	COG3562	capsule polysaccharide
MADE_RS13675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MADE_RS13690	COG0489	protein tyrosine kinase activity
MADE_RS13700	COG3409	Peptidoglycan-binding domain 1 protein
MADE_RS13700	COG3267	Type II secretory pathway component ExeA
MADE_RS13735	COG1560	Kdo2-lipid A biosynthetic process
MADE_RS13750	COG1960	acyl-CoA dehydrogenase activity
MADE_RS13770	COG3344	reverse transcriptase
MADE_RS13785	COG5001	Diguanylate cyclase
MADE_RS13785	COG3300	MHYT domain
MADE_RS13790	COG1435	thymidine kinase activity
MADE_RS13800	COG1609	Transcriptional regulator
MADE_RS13805	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MADE_RS13835	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MADE_RS13840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MADE_RS13845	COG1250	3-hydroxyacyl-CoA dehydrogenase
MADE_RS13845	COG1024	Enoyl-CoA hydratase
MADE_RS13860	COG1012	belongs to the aldehyde dehydrogenase family
MADE_RS13880	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
MADE_RS13905	COG1960	acyl-CoA dehydrogenase activity
MADE_RS13930	COG0745	RESPONSE REGULATOR receiver
MADE_RS13935	COG2205	protein histidine kinase activity
MADE_RS13975	COG2080	2 iron, 2 sulfur cluster binding
MADE_RS13980	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MADE_RS13985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MADE_RS14005	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_RS14010	COG4221	oxidoreductase activity
MADE_RS14015	COG0693	protein deglycase activity
MADE_RS14020	COG1295	ribonuclease BN
MADE_RS14060	COG2814	Major facilitator Superfamily
MADE_RS14075	COG0514	ATP-dependent DNA helicase (RecQ)
MADE_RS14105	COG4251	negative regulation of phosphorylation
MADE_RS14110	COG2133	pyrroloquinoline quinone binding
MADE_RS14125	COG0830	nickel cation binding
MADE_RS14150	COG0829	nickel cation binding
MADE_RS14190	COG0745	RESPONSE REGULATOR receiver
MADE_RS14195	COG3177	Filamentation induced by cAMP protein fic
MADE_RS14200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MADE_RS14205	COG1518	maintenance of DNA repeat elements
MADE_RS14240	COG1203	CRISPR-associated helicase, Cas3
MADE_RS14250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MADE_RS14250	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MADE_RS14265	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MADE_RS14270	COG2971	BadF BadG BcrA BcrD
MADE_RS14275	COG0583	DNA-binding transcription factor activity
MADE_RS14280	COG1620	l-lactate permease
MADE_RS14300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MADE_RS14305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MADE_RS14310	COG0006	proline dipeptidase activity
MADE_RS14650	COG0582	viral genome integration into host DNA
MADE_RS14655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MADE_RS14670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MADE_RS14675	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MADE_RS14680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MADE_RS14700	COG3313	Fe-S protein
MADE_RS14735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MADE_RS14740	COG0508	dehydrogenase complex catalyzes the overall conversion of
MADE_RS14745	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MADE_RS14760	COG3023	N-Acetylmuramoyl-L-alanine amidase
MADE_RS14765	COG3577	Aspartyl protease
MADE_RS14770	COG0157	Belongs to the NadC ModD family
MADE_RS14780	COG1459	type II secretion system
MADE_RS14785	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MADE_RS14790	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MADE_RS14790	COG0237	dephospho-CoA kinase activity
MADE_RS14800	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MADE_RS14805	COG3608	succinylglutamate desuccinylase aspartoacylase
MADE_RS14810	COG0840	transmembrane signaling receptor activity
MADE_RS14815	COG4566	intracellular signal transduction
MADE_RS14830	COG2198	Histidine kinase
MADE_RS14830	COG0643	Histidine kinase
MADE_RS14840	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MADE_RS14850	COG2201	protein-glutamate methylesterase activity
MADE_RS14855	COG0835	chemotaxis
MADE_RS14860	COG0840	transmembrane signaling receptor activity
MADE_RS14865	COG0494	nUDIX hydrolase
MADE_RS14875	COG0739	heme binding
MADE_RS14880	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MADE_RS14885	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MADE_RS14890	COG0849	cell division
MADE_RS14895	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MADE_RS14900	COG1181	Belongs to the D-alanine--D-alanine ligase family
MADE_RS14905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MADE_RS14915	COG0772	Belongs to the SEDS family
MADE_RS14920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MADE_RS14930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MADE_RS14935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MADE_RS14940	COG0768	penicillin binding
MADE_RS14945	COG3116	cell division
MADE_RS14955	COG2001	Belongs to the MraZ family
MADE_RS14995	COG0678	peroxiredoxin activity
MADE_RS14995	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MADE_RS15020	COG2204	response regulator
MADE_RS15025	COG2205	protein histidine kinase activity
MADE_RS15025	COG0784	Response regulator, receiver
MADE_RS15050	COG0668	transmembrane transport
MADE_RS15055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MADE_RS15060	COG0189	ligase activity
MADE_RS15065	COG1678	Uncharacterized ACR, COG1678
MADE_RS15070	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MADE_RS15095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MADE_RS15100	COG0762	integral membrane protein
MADE_RS15110	COG0446	pyridine nucleotide-disulphide oxidoreductase
MADE_RS15110	COG1902	pentaerythritol trinitrate reductase activity
MADE_RS15125	COG0625	glutathione transferase activity
MADE_RS15135	COG1764	response to oxidative stress
MADE_RS15140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MADE_RS15155	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MADE_RS15160	COG1396	sequence-specific DNA binding
MADE_RS15165	COG2814	Major facilitator Superfamily
MADE_RS15170	COG0724	RNA recognition motif
MADE_RS15195	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MADE_RS15200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MADE_RS15205	COG0083	homoserine kinase activity
MADE_RS15220	COG0583	DNA-binding transcription factor activity
MADE_RS15235	COG0640	Transcriptional regulator
MADE_RS15245	COG0431	NADPH-dependent FMN reductase
MADE_RS15250	COG0798	PFAM Bile acid sodium symporter
MADE_RS15255	COG2201	protein-glutamate methylesterase activity
MADE_RS15260	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
MADE_RS15270	COG0642	Histidine kinase
MADE_RS15295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MADE_RS15320	COG1748	Saccharopine dehydrogenase
MADE_RS15335	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MADE_RS15340	COG3107	peptidoglycan biosynthetic process
MADE_RS15350	COG0438	transferase activity, transferring glycosyl groups
MADE_RS15360	COG2823	Periplasmic or secreted lipoprotein
MADE_RS15380	COG4585	Histidine kinase
MADE_RS15385	COG2197	response regulator
MADE_RS15410	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MADE_RS15415	COG0372	Belongs to the citrate synthase family
MADE_RS15420	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MADE_RS15425	COG2828	Protein conserved in bacteria
MADE_RS15430	COG2203	Gaf domain
MADE_RS15430	COG2199	diguanylate cyclase activity
MADE_RS15435	COG1940	carbohydrate kinase activity
MADE_RS15455	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
MADE_RS15475	COG0784	Response regulator, receiver
MADE_RS15475	COG5002	protein histidine kinase activity
MADE_RS15475	COG2198	Histidine kinase
MADE_RS15480	COG3023	N-Acetylmuramoyl-L-alanine amidase
MADE_RS15485	COG0067	glutamate synthase
MADE_RS15485	COG0070	glutamate synthase
MADE_RS15485	COG0069	glutamate synthase activity
MADE_RS15490	COG0493	'glutamate synthase
MADE_RS15505	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MADE_RS15510	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MADE_RS15515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MADE_RS15520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MADE_RS15535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MADE_RS15540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MADE_RS15550	COG4942	peptidase
MADE_RS15555	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MADE_RS15560	COG0738	Major facilitator superfamily
MADE_RS15570	COG1902	pentaerythritol trinitrate reductase activity
MADE_RS15590	COG0625	glutathione transferase activity
MADE_RS15615	COG2894	cell division
MADE_RS15620	COG0850	regulation of cytokinetic process
MADE_RS15630	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
MADE_RS15645	COG1981	membrane
MADE_RS15660	COG1914	H( )-stimulated, divalent metal cation uptake system
MADE_RS15675	COG1217	gtp-binding protein TYPA
MADE_RS15680	COG0174	glutamine synthetase
MADE_RS15690	COG3852	Histidine kinase
MADE_RS15695	COG2204	response regulator
MADE_RS15700	COG3437	response regulator, receiver
MADE_RS15740	COG2205	protein histidine kinase activity
MADE_RS15740	COG3437	response regulator, receiver
MADE_RS15740	COG3850	Histidine kinase
MADE_RS15740	COG4999	Histidine kinase
MADE_RS15745	COG0525	valine-tRNA ligase activity
MADE_RS15750	COG2927	DNA polymerase III (CHI subunit)
MADE_RS15755	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MADE_RS15760	COG0795	lipopolysaccharide-transporting ATPase activity
MADE_RS15765	COG0795	lipopolysaccharide-transporting ATPase activity
MADE_RS15855	COG0673	inositol 2-dehydrogenase activity
MADE_RS15890	COG1858	cytochrome C peroxidase
MADE_RS15895	COG4771	TonB-dependent receptor
MADE_RS15910	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_RS15940	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MADE_RS15945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MADE_RS15950	COG4558	Periplasmic binding protein
MADE_RS15960	COG4206	TonB-dependent receptor
MADE_RS15970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MADE_RS16005	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MADE_RS16020	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MADE_RS16060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MADE_RS16065	COG0277	FAD linked oxidase domain protein
MADE_RS16075	COG1462	curli production assembly transport component CsgG
MADE_RS16105	COG2197	response regulator
MADE_RS16120	COG0513	Belongs to the DEAD box helicase family
MADE_RS16140	COG0800	Aldolase
MADE_RS16145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MADE_RS16180	COG2337	Toxic component of a toxin-antitoxin (TA) module
MADE_RS16210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MADE_RS16215	COG2010	Cytochrome c
MADE_RS16215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MADE_RS16235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MADE_RS16250	COG3264	Mechanosensitive ion channel
MADE_RS16250	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MADE_RS16290	COG0730	response to heat
MADE_RS16295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MADE_RS16310	COG4191	Histidine kinase
MADE_RS16320	COG0417	DNA replication proofreading
MADE_RS16330	COG0318	PFAM AMP-dependent synthetase and ligase
MADE_RS16375	COG1309	transcriptional regulator
MADE_RS16385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MADE_RS16395	COG1573	uracil-dna glycosylase
MADE_RS16400	COG3300	MHYT domain
MADE_RS16400	COG5001	Diguanylate cyclase
MADE_RS16420	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MADE_RS16440	COG1983	PspC domain protein
MADE_RS16445	COG1842	Phage shock protein A
MADE_RS16455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MADE_RS16460	COG0582	viral genome integration into host DNA
MADE_RS16470	COG4372	Transposase
MADE_RS16520	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MADE_RS16600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MADE_RS16610	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MADE_RS16615	COG0204	Acyl-transferase
MADE_RS16620	COG0204	Acyl-transferase
MADE_RS16625	COG0668	transmembrane transport
MADE_RS16640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MADE_RS16645	COG0733	neurotransmitter:sodium symporter activity
MADE_RS16660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MADE_RS16685	COG0848	biopolymer transport protein
MADE_RS16700	COG0457	Tetratricopeptide repeat
MADE_RS16705	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MADE_RS16715	COG1215	transferase activity, transferring glycosyl groups
MADE_RS16730	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MADE_RS16735	COG0702	epimerase
MADE_RS16750	COG5001	Diguanylate cyclase
MADE_RS16750	COG5002	protein histidine kinase activity
MADE_RS16760	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MADE_RS16770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MADE_RS16780	COG0583	DNA-binding transcription factor activity
MADE_RS16785	COG0121	glutamine amidotransferase
MADE_RS16790	COG4682	membrane
MADE_RS16810	COG1953	Uracil, thiamine, allantoin
MADE_RS16815	COG4771	TonB-dependent receptor
MADE_RS16825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MADE_RS16830	COG0778	Nitroreductase
MADE_RS16835	COG0596	Alpha beta hydrolase
MADE_RS16840	COG0251	oxidation-reduction process
MADE_RS16845	COG1335	isochorismatase
MADE_RS16850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MADE_RS16855	COG1309	transcriptional regulator
MADE_RS16870	COG4628	conserved protein (DUF2132)
MADE_RS16875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MADE_RS16885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MADE_RS16895	COG1477	protein flavinylation
MADE_RS16900	COG2871	sodium ion transport
MADE_RS16905	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MADE_RS16910	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MADE_RS16915	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MADE_RS16920	COG1805	sodium ion transport
MADE_RS16925	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MADE_RS16930	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MADE_RS16935	COG0545	Peptidyl-prolyl cis-trans isomerase
MADE_RS16940	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MADE_RS16955	COG0039	L-malate dehydrogenase activity
MADE_RS16960	COG1438	arginine binding
MADE_RS16985	COG0572	uridine kinase
MADE_RS16990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MADE_RS17015	COG2176	DNA-directed DNA polymerase activity
MADE_RS17025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MADE_RS17035	COG2205	protein histidine kinase activity
MADE_RS17045	COG0189	ligase activity
MADE_RS17055	COG4067	protein conserved in archaea
MADE_RS17055	COG0189	ligase activity
MADE_RS17070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MADE_RS17080	COG1283	sodium-dependent phosphate transmembrane transporter activity
MADE_RS17085	COG0667	Aldo Keto reductase
MADE_RS17100	COG5001	Diguanylate cyclase
MADE_RS17135	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MADE_RS17145	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MADE_RS17150	COG0840	transmembrane signaling receptor activity
MADE_RS17195	COG2274	protein secretion by the type I secretion system
MADE_RS17200	COG0583	DNA-binding transcription factor activity
MADE_RS17225	COG1091	dTDP-4-dehydrorhamnose reductase activity
MADE_RS17275	COG2801	Transposase and inactivated derivatives
MADE_RS17310	COG3119	arylsulfatase activity
MADE_RS17325	COG0438	transferase activity, transferring glycosyl groups
MADE_RS17325	COG1216	Glycosyl transferase, family 2
MADE_RS17330	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MADE_RS17330	COG0662	Cupin 2, conserved barrel domain protein
MADE_RS17350	COG0202	RNA polymerase activity
MADE_RS17375	COG0201	protein transport
MADE_RS17395	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MADE_RS17455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MADE_RS17460	COG0557	exoribonuclease II activity
MADE_RS17490	COG4771	TonB-dependent receptor
MADE_RS17505	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
MADE_RS17535	COG2234	aminopeptidase activity
MADE_RS17545	COG4251	negative regulation of phosphorylation
MADE_RS17555	COG1271	oxidase subunit
MADE_RS17560	COG1294	oxidase, subunit
MADE_RS17565	COG1522	sequence-specific DNA binding
MADE_RS17575	COG1278	Cold shock
MADE_RS17580	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MADE_RS17600	COG0339	signal peptide processing
MADE_RS17605	COG0745	RESPONSE REGULATOR receiver
MADE_RS17615	COG3852	Histidine kinase
MADE_RS17625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MADE_RS17630	COG0243	molybdopterin cofactor binding
MADE_RS17635	COG0823	Involved in the tonB-independent uptake of proteins
MADE_RS17635	COG1506	peptidase
MADE_RS17635	COG4946	Tricorn protease homolog
MADE_RS17680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MADE_RS17690	COG2197	response regulator
MADE_RS17700	COG0189	ligase activity
MADE_RS17720	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MADE_RS17725	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MADE_RS17730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MADE_RS17745	COG0281	malic enzyme
MADE_RS17755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MADE_RS17785	COG0456	acetyltransferase
MADE_RS17795	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MADE_RS17800	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MADE_RS17805	COG2177	Part of the ABC transporter FtsEX involved in
MADE_RS17810	COG2884	Cell division ATP-binding protein ftsE
MADE_RS17815	COG0552	protein localization to endoplasmic reticulum
MADE_RS17820	COG0742	ribosomal rna small subunit methyltransferase
MADE_RS17830	COG2095	MarC family integral membrane protein
MADE_RS17850	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MADE_RS17855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MADE_RS17860	COG0617	tRNA 3'-terminal CCA addition
MADE_RS17865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MADE_RS17880	COG0076	glutamate decarboxylase activity
MADE_RS17895	COG0842	Transport permease protein
MADE_RS17900	COG1131	(ABC) transporter
MADE_RS17905	COG0745	RESPONSE REGULATOR receiver
MADE_RS17910	COG2205	protein histidine kinase activity
MADE_RS17915	COG4774	siderophore transport
MADE_RS17935	COG1253	flavin adenine dinucleotide binding
MADE_RS17945	COG1966	Carbon starvation protein
MADE_RS17955	COG0657	acetylesterase activity
MADE_RS17970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MADE_RS17975	COG0049	tRNA binding
MADE_RS17980	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MADE_RS17985	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MADE_RS17990	COG0085	RNA polymerase activity
MADE_RS17995	COG0222	ribosome binding
MADE_RS18000	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MADE_RS18005	COG0081	regulation of translation
MADE_RS18010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MADE_RS18030	COG0250	Participates in transcription elongation, termination and antitermination
MADE_RS18035	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MADE_RS18045	COG1132	(ABC) transporter
MADE_RS18050	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MADE_RS18055	COG3590	peptidase
MADE_RS18065	COG0513	Belongs to the DEAD box helicase family
MADE_RS18070	COG0418	dihydroorotase activity
MADE_RS18075	COG3040	lipid binding
MADE_RS18080	COG4989	oxidoreductase activity
MADE_RS18085	COG0346	lactoylglutathione lyase activity
MADE_RS18090	COG0668	transmembrane transport
MADE_RS18110	COG0302	gtp cyclohydrolase
MADE_RS18120	COG2957	Belongs to the agmatine deiminase family
MADE_RS18125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MADE_RS18135	COG1201	RNA secondary structure unwinding
MADE_RS18145	COG1793	dna ligase
MADE_RS18150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MADE_RS18155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MADE_RS18165	COG0646	methionine synthase
MADE_RS18165	COG1410	methionine synthase
MADE_RS18170	COG0625	glutathione transferase activity
MADE_RS18175	COG0625	glutathione transferase activity
MADE_RS18185	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MADE_RS18200	COG1012	belongs to the aldehyde dehydrogenase family
MADE_RS18205	COG0028	Belongs to the TPP enzyme family
MADE_RS18215	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MADE_RS18220	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MADE_RS18225	COG0330	HflC and HflK could
MADE_RS18230	COG0330	HflC and HflK could
MADE_RS18235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MADE_RS18240	COG1923	regulation of RNA biosynthetic process
MADE_RS18245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MADE_RS18260	COG0802	atpase or kinase
MADE_RS18265	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MADE_RS18265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MADE_RS18270	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MADE_RS18290	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
MADE_RS18295	COG0735	belongs to the Fur family
MADE_RS18315	COG0305	Participates in initiation and elongation during chromosome replication
MADE_RS18340	COG2258	MOSC domain
MADE_RS18370	COG2205	protein histidine kinase activity
MADE_RS18390	COG0840	transmembrane signaling receptor activity
MADE_RS18395	COG5002	protein histidine kinase activity
MADE_RS18400	COG0840	transmembrane signaling receptor activity
MADE_RS18425	COG1757	Na H antiporter
MADE_RS18430	COG1472	Belongs to the glycosyl hydrolase 3 family
MADE_RS18440	COG2723	6-phospho-beta-galactosidase activity
MADE_RS18445	COG1609	Transcriptional regulator
MADE_RS18450	COG0477	Major facilitator Superfamily
MADE_RS18450	COG2814	Major facilitator Superfamily
MADE_RS18455	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MADE_RS18460	COG4988	ABC transporter
MADE_RS18470	COG1294	oxidase, subunit
MADE_RS18510	COG4319	ketosteroid isomerase
MADE_RS18530	COG2375	cellular response to nickel ion
MADE_RS18535	COG3237	CsbD-like
MADE_RS18580	COG3038	cytochrome b561
MADE_RS18610	COG2067	long-chain fatty acid transport protein
MADE_RS18615	COG2130	NADP-dependent
MADE_RS18620	COG4251	negative regulation of phosphorylation
MADE_RS18620	COG3706	GGDEF domain
MADE_RS18620	COG2203	Gaf domain
MADE_RS18620	COG5001	Diguanylate cyclase
MADE_RS18625	COG2205	protein histidine kinase activity
MADE_RS18625	COG0784	Response regulator, receiver
MADE_RS18650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MADE_RS18655	COG2181	nitrate reductase activity
MADE_RS18660	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
MADE_RS18670	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MADE_RS18675	COG3850	Histidine kinase
MADE_RS18680	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MADE_RS18700	COG2197	response regulator
MADE_RS18710	COG2832	Protein of unknown function (DUF454)
MADE_RS18720	COG0314	molybdopterin synthase activity
MADE_RS18725	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MADE_RS18740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MADE_RS18755	COG3154	lipid carrier protein
MADE_RS18760	COG0028	Belongs to the TPP enzyme family
MADE_RS18765	COG0826	peptidase U32
MADE_RS18770	COG0826	peptidase U32
MADE_RS18780	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
MADE_RS18785	COG3604	Transcriptional regulator
MADE_RS18810	COG0515	serine threonine protein kinase
MADE_RS18820	COG1136	(ABC) transporter
MADE_RS18840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MADE_RS18845	COG1349	DNA-binding transcription factor activity
MADE_RS18850	COG0673	inositol 2-dehydrogenase activity
MADE_RS18865	COG0697	spore germination
MADE_RS18870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MADE_RS18880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MADE_RS18885	COG1166	arginine decarboxylase activity
MADE_RS18895	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MADE_RS18950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MADE_RS18955	COG0109	protoheme IX farnesyltransferase activity
MADE_RS18975	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MADE_RS18990	COG1487	ribonuclease activity
MADE_RS19020	COG3030	protein affecting phage T7 exclusion by the F plasmid
MADE_RS19025	COG1324	tolerance protein
MADE_RS19030	COG4232	protein-disulfide reductase activity
MADE_RS19035	COG0739	heme binding
MADE_RS19040	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MADE_RS19045	COG0511	ligase activity, forming carbon-carbon bonds
MADE_RS19050	COG0439	Biotin carboxylase
MADE_RS19100	COG0154	amidase activity
MADE_RS19115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MADE_RS19120	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MADE_RS19150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MADE_RS19155	COG3954	Phosphoribulokinase
MADE_RS19180	COG1501	Belongs to the glycosyl hydrolase 31 family
MADE_RS19185	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MADE_RS19195	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MADE_RS19215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MADE_RS19220	COG1459	type II secretion system
MADE_RS19225	COG2165	general secretion pathway protein
MADE_RS19230	COG2165	general secretion pathway protein
MADE_RS19235	COG2165	general secretion pathway protein
MADE_RS19240	COG4795	General secretion pathway protein
MADE_RS19255	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
MADE_RS19270	COG1012	belongs to the aldehyde dehydrogenase family
MADE_RS19280	COG1011	Hydrolase
MADE_RS19285	COG0494	nUDIX hydrolase
MADE_RS19290	COG1218	3'(2'),5'-bisphosphate nucleotidase
MADE_RS19300	COG2943	transferase activity, transferring hexosyl groups
MADE_RS19320	COG3089	Belongs to the UPF0270 family
MADE_RS19325	COG0429	hydrolase of the alpha beta-hydrolase fold
MADE_RS19350	COG2900	Belongs to the SlyX family
MADE_RS19360	COG0545	Peptidyl-prolyl cis-trans isomerase
MADE_RS19370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MADE_RS19395	COG0596	Alpha beta hydrolase
MADE_RS19400	COG1040	competence protein
MADE_RS19420	COG1794	racemase activity, acting on amino acids and derivatives
MADE_RS19435	COG0726	polysaccharide deacetylase
MADE_RS19435	COG1649	PFAM Uncharacterised BCR, COG1649
MADE_RS19445	COG1999	signal sequence binding
MADE_RS19450	COG0109	protoheme IX farnesyltransferase activity
MADE_RS19455	COG1612	heme a metabolic process
MADE_RS19480	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MADE_RS19485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MADE_RS19490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MADE_RS19510	COG0129	dihydroxy-acid dehydratase activity
MADE_RS19525	COG0606	chelatase, subunit chli
MADE_RS19530	COG0583	DNA-binding transcription factor activity
MADE_RS19540	COG2814	Major facilitator Superfamily
MADE_RS19550	COG0729	surface antigen
MADE_RS19555	COG2911	Protein conserved in bacteria
MADE_RS19580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MADE_RS19590	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MADE_RS19610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MADE_RS19635	COG1228	amidohydrolase
MADE_RS19660	COG0425	Belongs to the sulfur carrier protein TusA family
MADE_RS19675	COG1561	YicC-like family, N-terminal region
MADE_RS19685	COG3550	peptidyl-serine autophosphorylation
MADE_RS19690	COG3620	sequence-specific DNA binding
MADE_RS19780	COG3177	Filamentation induced by cAMP protein fic
MADE_RS19790	COG1609	Transcriptional regulator
MADE_RS19805	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MADE_RS19805	COG2199	diguanylate cyclase activity
MADE_RS19830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MADE_RS19850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MADE_RS19855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MADE_RS19875	COG1475	DNA binding
MADE_RS19880	COG1192	Involved in chromosome partitioning
MADE_RS19905	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MADE_RS19910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MADE_RS19980	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
MADE_RS20065	COG0746	molybdenum cofactor guanylyltransferase activity
MADE_RS20075	COG2184	nucleotidyltransferase activity
MADE_RS20135	COG0789	Transcriptional regulator
MADE_RS20140	COG3039	Transposase
MADE_RS20235	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MADE_RS20320	COG0789	Transcriptional regulator
MADE_RS20355	COG5507	3-demethylubiquinone-9 3-methyltransferase
MADE_RS20385	COG2801	Transposase and inactivated derivatives
MADE_RS20390	COG4890	Cyd operon protein YbgT
MADE_RS20410	COG0759	Could be involved in insertion of integral membrane proteins into the membrane