locus-tag	class	description
I533_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I533_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I533_RS00040	COG2818	Glycosylase
I533_RS00050	COG3078	GTPase activator activity
I533_RS00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I533_RS00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I533_RS00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I533_RS00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I533_RS00085	COG0569	domain protein
I533_RS00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I533_RS00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I533_RS00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I533_RS00110	COG0758	DNA mediated transformation
I533_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
I533_RS00130	COG0408	coproporphyrinogen oxidase activity
I533_RS00135	COG3047	cAMP biosynthetic process
I533_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I533_RS00180	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I533_RS00225	COG2234	aminopeptidase activity
I533_RS00230	COG0463	Glycosyl transferase, family 2
I533_RS00240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I533_RS00265	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I533_RS00295	COG3642	lipopolysaccharide core region biosynthetic process
I533_RS00300	COG0859	PFAM glycosyl transferase family 9
I533_RS00330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I533_RS00345	COG3161	chorismate lyase activity
I533_RS00350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I533_RS00370	COG0210	DNA helicase
I533_RS00400	COG1757	Na H antiporter
I533_RS00415	COG1959	2 iron, 2 sulfur cluster binding
I533_RS00420	COG0730	response to heat
I533_RS00435	COG4771	TonB-dependent receptor
I533_RS00450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I533_RS00455	COG4988	ABC transporter
I533_RS00465	COG1271	oxidase subunit
I533_RS00475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I533_RS00475	COG0425	Belongs to the sulfur carrier protein TusA family
I533_RS00485	COG0450	alkyl hydroperoxide reductase
I533_RS00495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I533_RS00525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I533_RS00545	COG0582	viral genome integration into host DNA
I533_RS00575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I533_RS00580	COG0842	Transport permease protein
I533_RS00580	COG1129	ABC transporter
I533_RS00585	COG0842	Transport permease protein
I533_RS00605	COG1960	acyl-CoA dehydrogenase activity
I533_RS00610	COG0583	DNA-binding transcription factor activity
I533_RS00620	COG3106	COG3106 Predicted ATPase
I533_RS00635	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I533_RS00650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I533_RS00655	COG0352	thiamine-phosphate diphosphorylase activity
I533_RS00665	COG3071	HemY protein
I533_RS00670	COG2959	enzyme of heme biosynthesis
I533_RS00680	COG0181	hydroxymethylbilane synthase activity
I533_RS00695	COG0194	GDP metabolic process
I533_RS00705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I533_RS00715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I533_RS00720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I533_RS00730	COG0678	peroxiredoxin activity
I533_RS00745	COG1178	ABC-type Fe3 transport system permease component
I533_RS00750	COG3842	ATPase activity
I533_RS00755	COG0668	transmembrane transport
I533_RS00760	COG2081	HI0933 family
I533_RS00785	COG2200	EAL domain
I533_RS00790	COG0583	DNA-binding transcription factor activity
I533_RS00815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I533_RS00830	COG0427	acetyl-CoA hydrolase
I533_RS00835	COG0123	including yeast histone deacetylase and acetoin utilization protein
I533_RS00850	COG0840	transmembrane signaling receptor activity
I533_RS00860	COG3064	Membrane
I533_RS00870	COG5002	protein histidine kinase activity
I533_RS00870	COG5001	Diguanylate cyclase
I533_RS00885	COG0514	ATP-dependent DNA helicase (RecQ)
I533_RS00890	COG2239	Acts as a magnesium transporter
I533_RS00895	COG2962	Rard protein
I533_RS00905	COG0210	DNA helicase
I533_RS00915	COG1011	Hydrolase
I533_RS00920	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I533_RS00930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I533_RS00935	COG0019	diaminopimelate decarboxylase activity
I533_RS00965	COG0163	prenyltransferase activity
I533_RS00970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I533_RS00980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I533_RS01000	COG1077	Cell shape determining protein MreB Mrl
I533_RS01010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I533_RS01015	COG2814	Major facilitator Superfamily
I533_RS01020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I533_RS01045	COG1085	galactose-1-phosphate uridylyltransferase
I533_RS01050	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I533_RS01060	COG0629	single-stranded DNA binding
I533_RS01075	COG3250	beta-galactosidase activity
I533_RS01090	COG1349	DNA-binding transcription factor activity
I533_RS01135	COG3267	Type II secretory pathway component ExeA
I533_RS01135	COG3409	Peptidoglycan-binding domain 1 protein
I533_RS01145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I533_RS01150	COG1459	type II secretion system
I533_RS01160	COG2165	general secretion pathway protein
I533_RS01165	COG2165	general secretion pathway protein
I533_RS01195	COG1077	Cell shape determining protein MreB Mrl
I533_RS01200	COG1792	Involved in formation and maintenance of cell shape
I533_RS01205	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I533_RS01215	COG1530	ribonuclease E activity
I533_RS01225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I533_RS01230	COG0312	modulator of DNA gyrase
I533_RS01235	COG3028	Belongs to the UPF0307 family
I533_RS01240	COG0312	modulator of DNA gyrase
I533_RS01255	COG0745	RESPONSE REGULATOR receiver
I533_RS01260	COG4191	Histidine kinase
I533_RS01260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I533_RS01265	COG0297	glycogen (starch) synthase activity
I533_RS01275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I533_RS01280	COG0596	Alpha beta hydrolase
I533_RS01305	COG1204	response to ionizing radiation
I533_RS01315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I533_RS01320	COG5002	protein histidine kinase activity
I533_RS01325	COG0745	RESPONSE REGULATOR receiver
I533_RS01345	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I533_RS01410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I533_RS01410	COG1017	nitric oxide dioxygenase activity
I533_RS01430	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I533_RS01460	COG0375	protein maturation
I533_RS01470	COG0409	Hydrogenase expression formation protein
I533_RS01480	COG0309	Hydrogenase expression formation protein (HypE)
I533_RS01485	COG0789	Transcriptional regulator
I533_RS01490	COG2217	Heavy metal translocating P-type atpase
I533_RS01570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I533_RS01580	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I533_RS01590	COG0463	Glycosyl transferase, family 2
I533_RS01595	COG0745	RESPONSE REGULATOR receiver
I533_RS01665	COG0789	Transcriptional regulator
I533_RS01670	COG2217	Heavy metal translocating P-type atpase
I533_RS01705	COG0531	amino acid
I533_RS01715	COG2132	Multicopper oxidase
I533_RS01740	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I533_RS01810	COG1609	Transcriptional regulator
I533_RS01815	COG0673	inositol 2-dehydrogenase activity
I533_RS01825	COG2211	Major facilitator Superfamily
I533_RS01850	COG1454	alcohol dehydrogenase
I533_RS01910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I533_RS01930	COG0089	rRNA binding
I533_RS01940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I533_RS01950	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I533_RS01965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I533_RS01970	COG0438	transferase activity, transferring glycosyl groups
I533_RS01980	COG1519	Transferase
I533_RS02000	COG0840	transmembrane signaling receptor activity
I533_RS02015	COG0788	formyltetrahydrofolate deformylase activity
I533_RS02025	COG1643	Atp-dependent helicase
I533_RS02030	COG2951	lytic endotransglycosylase activity
I533_RS02035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I533_RS02045	COG2354	Protein conserved in bacteria
I533_RS02065	COG0004	ammonium transporteR
I533_RS02070	COG0405	Gamma-glutamyltransferase
I533_RS02075	COG2837	iron assimilation
I533_RS02090	COG0540	Belongs to the ATCase OTCase family
I533_RS02115	COG0784	Response regulator, receiver
I533_RS02115	COG2205	protein histidine kinase activity
I533_RS02115	COG5002	protein histidine kinase activity
I533_RS02130	COG3300	MHYT domain
I533_RS02130	COG5001	Diguanylate cyclase
I533_RS02140	COG1012	belongs to the aldehyde dehydrogenase family
I533_RS02150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I533_RS02165	COG0180	Tryptophanyl-tRNA synthetase
I533_RS02170	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I533_RS02190	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I533_RS02200	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I533_RS02235	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I533_RS02240	COG0281	malic enzyme
I533_RS02250	COG0625	glutathione transferase activity
I533_RS02260	COG0753	catalase activity
I533_RS02280	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I533_RS02280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I533_RS02290	COG0137	argininosuccinate synthase activity
I533_RS02310	COG1803	Methylglyoxal synthase
I533_RS02320	COG0745	RESPONSE REGULATOR receiver
I533_RS02325	COG2205	protein histidine kinase activity
I533_RS02330	COG2267	carboxylic ester hydrolase activity
I533_RS02335	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I533_RS02345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I533_RS02355	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I533_RS02360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I533_RS02365	COG4942	peptidase
I533_RS02370	COG2861	carbohydrate metabolic process
I533_RS02395	COG1162	GTPase activity
I533_RS02400	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I533_RS02440	COG0270	DNA (cytosine-5-)-methyltransferase activity
I533_RS02450	COG0028	Belongs to the TPP enzyme family
I533_RS02470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I533_RS02475	COG0805	protein transport
I533_RS02485	COG0084	hydrolase, TatD family'
I533_RS02490	COG3706	GGDEF domain
I533_RS02490	COG4251	negative regulation of phosphorylation
I533_RS02490	COG5001	Diguanylate cyclase
I533_RS02490	COG2203	Gaf domain
I533_RS02500	COG0248	Ppx GppA phosphatase
I533_RS02505	COG0513	Belongs to the DEAD box helicase family
I533_RS02510	COG3118	belongs to the thioredoxin family
I533_RS02515	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I533_RS02520	COG1473	amidohydrolase
I533_RS02525	COG5002	protein histidine kinase activity
I533_RS02525	COG0784	Response regulator, receiver
I533_RS02530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I533_RS02535	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I533_RS02540	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I533_RS02555	COG0783	Belongs to the Dps family
I533_RS02560	COG2133	pyrroloquinoline quinone binding
I533_RS02565	COG4946	Tricorn protease homolog
I533_RS02565	COG0823	Involved in the tonB-independent uptake of proteins
I533_RS02565	COG1506	peptidase
I533_RS02575	COG3118	belongs to the thioredoxin family
I533_RS02590	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I533_RS02600	COG1012	belongs to the aldehyde dehydrogenase family
I533_RS02620	COG1757	Na H antiporter
I533_RS02635	COG3876	Protein conserved in bacteria
I533_RS02640	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I533_RS02650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I533_RS02685	COG2824	Alkylphosphonate utilization operon protein PhnA
I533_RS02690	COG0454	-acetyltransferase
I533_RS02715	COG3093	addiction module antidote protein HigA
I533_RS02730	COG2026	Addiction module toxin, RelE StbE family
I533_RS02755	COG3547	Transposase (IS116 IS110 IS902 family)
I533_RS02790	COG0183	Belongs to the thiolase family
I533_RS02795	COG1250	3-hydroxyacyl-CoA dehydrogenase
I533_RS02795	COG1024	Enoyl-CoA hydratase
I533_RS02805	COG0006	proline dipeptidase activity
I533_RS02815	COG0142	geranyltranstransferase activity
I533_RS02845	COG4942	peptidase
I533_RS02845	COG1388	LysM domain
I533_RS02850	COG1238	metal cluster binding
I533_RS02860	COG0585	pseudouridine synthase activity
I533_RS02865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I533_RS02875	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I533_RS02885	COG0840	transmembrane signaling receptor activity
I533_RS02890	COG0506	proline dehydrogenase activity
I533_RS02890	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I533_RS02890	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I533_RS02915	COG0494	nUDIX hydrolase
I533_RS02920	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I533_RS02925	COG0730	response to heat
I533_RS02930	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I533_RS02935	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I533_RS02970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I533_RS02980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I533_RS02990	COG1648	precorrin-2 dehydrogenase activity
I533_RS02990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I533_RS02995	COG0513	Belongs to the DEAD box helicase family
I533_RS03010	COG1538	Outer membrane efflux protein
I533_RS03015	COG0494	nUDIX hydrolase
I533_RS03025	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I533_RS03030	COG3150	esterase
I533_RS03035	COG0187	DNA topoisomerase II activity
I533_RS03045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I533_RS03070	COG1509	lysine 2,3-aminomutase activity
I533_RS03075	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I533_RS03080	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I533_RS03095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I533_RS03110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I533_RS03125	COG0271	Belongs to the BolA IbaG family
I533_RS03140	COG3707	response regulator
I533_RS03155	COG0659	secondary active sulfate transmembrane transporter activity
I533_RS03160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I533_RS03170	COG0243	molybdopterin cofactor binding
I533_RS03175	COG1648	precorrin-2 dehydrogenase activity
I533_RS03175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I533_RS03180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I533_RS03190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I533_RS03190	COG1116	anion transmembrane transporter activity
I533_RS03200	COG1116	anion transmembrane transporter activity
I533_RS03215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I533_RS03220	COG4206	TonB-dependent receptor
I533_RS03230	COG0348	domain, Protein
I533_RS03245	COG1960	acyl-CoA dehydrogenase activity
I533_RS03250	COG1028	Short-chain dehydrogenase reductase Sdr
I533_RS03260	COG4948	Mandelate Racemase Muconate Lactonizing
I533_RS03280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I533_RS03305	COG0358	DNA primase activity
I533_RS03310	COG1610	YqeY-like protein
I533_RS03330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I533_RS03335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I533_RS03350	COG0537	adenosine 5'-monophosphoramidase activity
I533_RS03365	COG3135	benzoate transporter
I533_RS03370	COG1396	sequence-specific DNA binding
I533_RS03375	COG2974	May be involved in recombination
I533_RS03380	COG4191	Histidine kinase
I533_RS03380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I533_RS03385	COG0745	RESPONSE REGULATOR receiver
I533_RS03390	COG5002	protein histidine kinase activity
I533_RS03415	COG0811	peptide transport
I533_RS03420	COG0811	peptide transport
I533_RS03425	COG0848	biopolymer transport protein
I533_RS03430	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I533_RS03440	COG3437	response regulator, receiver
I533_RS03460	COG0527	aspartate kinase activity
I533_RS03470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I533_RS03475	COG2967	ApaG domain
I533_RS03485	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I533_RS03490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I533_RS03495	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I533_RS03500	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I533_RS03510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I533_RS03530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I533_RS03545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I533_RS03550	COG3956	TIGRFAM MazG family protein
I533_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
I533_RS03585	COG0318	PFAM AMP-dependent synthetase and ligase
I533_RS03595	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I533_RS03605	COG0463	Glycosyl transferase, family 2
I533_RS03640	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I533_RS03645	COG0723	plastoquinol--plastocyanin reductase activity
I533_RS03650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I533_RS03655	COG2857	Cytochrome c1
I533_RS03660	COG0625	glutathione transferase activity
I533_RS03665	COG2969	positive regulation of protein catabolic process
I533_RS03670	COG2239	Acts as a magnesium transporter
I533_RS03675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I533_RS03695	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I533_RS03700	COG1137	ATPase activity
I533_RS03705	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I533_RS03715	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I533_RS03730	COG1127	ABC transporter
I533_RS03735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I533_RS03740	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I533_RS03745	COG2854	intermembrane phospholipid transfer
I533_RS03755	COG5007	Belongs to the BolA IbaG family
I533_RS03765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I533_RS03770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I533_RS03780	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I533_RS03825	COG4771	TonB-dependent receptor
I533_RS03830	COG0697	spore germination
I533_RS03840	COG0784	Response regulator, receiver
I533_RS03840	COG2205	protein histidine kinase activity
I533_RS03865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I533_RS03875	COG0126	phosphoglycerate kinase activity
I533_RS03880	COG3588	fructose-bisphosphate aldolase
I533_RS03890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I533_RS03900	COG1538	Outer membrane efflux protein
I533_RS03905	COG4946	Tricorn protease homolog
I533_RS03905	COG0823	Involved in the tonB-independent uptake of proteins
I533_RS03905	COG1506	peptidase
I533_RS03910	COG0248	Ppx GppA phosphatase
I533_RS03915	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I533_RS03925	COG0573	inorganic phosphate transmembrane transporter activity
I533_RS03935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I533_RS03945	COG0306	phosphate transporter
I533_RS03955	COG0583	DNA-binding transcription factor activity
I533_RS03965	COG1272	protein, Hemolysin III
I533_RS03970	COG1846	Transcriptional regulator
I533_RS03975	COG1764	response to oxidative stress
I533_RS04040	COG1739	Uncharacterized protein family UPF0029
I533_RS04050	COG0420	3'-5' exonuclease activity
I533_RS04055	COG0419	ATPase involved in DNA repair
I533_RS04075	COG2188	Transcriptional regulator
I533_RS04085	COG2986	histidine ammonia-lyase
I533_RS04110	COG0668	transmembrane transport
I533_RS04165	COG1346	cytolysis
I533_RS04195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I533_RS04205	COG0513	Belongs to the DEAD box helicase family
I533_RS04220	COG3267	Type II secretory pathway component ExeA
I533_RS04220	COG3409	Peptidoglycan-binding domain 1 protein
I533_RS04235	COG0066	3-isopropylmalate dehydratase activity
I533_RS04245	COG0473	3-isopropylmalate dehydrogenase activity
I533_RS04250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I533_RS04270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I533_RS04285	COG4555	ABC transporter
I533_RS04290	COG1668	transmembrane transport
I533_RS04310	COG4133	protoheme IX ABC transporter activity
I533_RS04315	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I533_RS04320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I533_RS04325	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I533_RS04335	COG1138	Cytochrome C-type biogenesis protein
I533_RS04340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I533_RS04355	COG2853	Lipoprotein
I533_RS04360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I533_RS04400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I533_RS04415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I533_RS04420	COG1555	photosystem II stabilization
I533_RS04420	COG1596	polysaccharide export
I533_RS04425	COG0473	3-isopropylmalate dehydrogenase activity
I533_RS04440	COG1611	Belongs to the LOG family
I533_RS04450	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I533_RS04450	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I533_RS04505	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I533_RS04510	COG0024	Methionine aminopeptidase
I533_RS04515	COG0052	Belongs to the universal ribosomal protein uS2 family
I533_RS04525	COG0528	UMP kinase activity
I533_RS04540	COG0575	Belongs to the CDS family
I533_RS04565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I533_RS04570	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I533_RS04585	COG0587	DNA-directed DNA polymerase activity
I533_RS04590	COG0825	malonyl-CoA metabolic process
I533_RS04595	COG0037	tRNA processing
I533_RS04625	COG0047	phosphoribosylformylglycinamidine synthase activity
I533_RS04625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I533_RS04630	COG2840	Smr protein MutS2
I533_RS04660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I533_RS04665	COG2197	response regulator
I533_RS04700	COG0784	Response regulator, receiver
I533_RS04700	COG0835	chemotaxis
I533_RS04705	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I533_RS04710	COG1815	bacterial-type flagellum-dependent cell motility
I533_RS04730	COG4787	bacterial-type flagellum-dependent cell motility
I533_RS04750	COG3951	Flagellar rod assembly protein muramidase FlgJ
I533_RS04750	COG1705	Flagellar rod assembly protein muramidase FlgJ
I533_RS04755	COG1256	bacterial-type flagellum assembly
I533_RS04775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I533_RS04780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I533_RS04795	COG1516	flagellar protein fliS
I533_RS04815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I533_RS04830	COG2089	acid synthase
I533_RS04840	COG1083	cytidylyl-transferase
I533_RS04845	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I533_RS04850	COG1086	Polysaccharide biosynthesis protein
I533_RS04880	COG1677	Flagellar hook-basal body complex protein FliE
I533_RS04885	COG1766	The M ring may be actively involved in energy transduction
I533_RS04890	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I533_RS04940	COG1987	bacterial-type flagellum assembly
I533_RS04955	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I533_RS04980	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I533_RS04985	COG0643	Histidine kinase
I533_RS04985	COG2198	Histidine kinase
I533_RS04985	COG0784	Response regulator, receiver
I533_RS04995	COG1192	Involved in chromosome partitioning
I533_RS05005	COG0835	chemotaxis
I533_RS05020	COG0646	methionine synthase
I533_RS05020	COG1410	methionine synthase
I533_RS05025	COG1410	methionine synthase
I533_RS05025	COG0646	methionine synthase
I533_RS05035	COG3123	guanosine phosphorylase activity
I533_RS05045	COG0583	DNA-binding transcription factor activity
I533_RS05050	COG0583	DNA-binding transcription factor activity
I533_RS05060	COG0659	secondary active sulfate transmembrane transporter activity
I533_RS05075	COG3590	peptidase
I533_RS05085	COG2137	regulation of response to DNA damage stimulus
I533_RS05090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I533_RS05120	COG0511	ligase activity, forming carbon-carbon bonds
I533_RS05120	COG5016	pyruvate
I533_RS05125	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I533_RS05130	COG4172	Belongs to the ABC transporter superfamily
I533_RS05140	COG4171	peptide transport system, permease
I533_RS05145	COG4168	peptide transport system, permease
I533_RS05150	COG0747	negative chemotaxis
I533_RS05155	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I533_RS05170	COG0625	glutathione transferase activity
I533_RS05175	COG1522	sequence-specific DNA binding
I533_RS05235	COG0811	peptide transport
I533_RS05240	COG0811	peptide transport
I533_RS05245	COG0848	biopolymer transport protein
I533_RS05260	COG1444	tRNA N-acetyltransferase activity
I533_RS05300	COG0583	DNA-binding transcription factor activity
I533_RS05305	COG2814	Major facilitator Superfamily
I533_RS05310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I533_RS05315	COG0656	L-ascorbic acid biosynthetic process
I533_RS05335	COG1846	Transcriptional regulator
I533_RS05395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I533_RS05420	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I533_RS05435	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I533_RS05440	COG1401	restriction endodeoxyribonuclease activity
I533_RS05485	COG4584	PFAM Integrase catalytic
I533_RS05500	COG1484	DNA-dependent DNA replication
I533_RS05550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I533_RS05565	COG0681	Belongs to the peptidase S26 family
I533_RS05605	COG0629	single-stranded DNA binding
I533_RS05620	COG0714	Associated with various cellular activities
I533_RS05645	COG2003	Belongs to the UPF0758 family
I533_RS05760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I533_RS05850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I533_RS05900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I533_RS05905	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I533_RS05910	COG0564	pseudouridine synthase activity
I533_RS05920	COG0612	Peptidase, M16
I533_RS05925	COG2918	glutathione biosynthetic process
I533_RS05945	COG2840	Smr protein MutS2
I533_RS05950	COG2890	protein-(glutamine-N5) methyltransferase activity
I533_RS05965	COG2719	SpoVR family
I533_RS05970	COG2718	Belongs to the UPF0229 family
I533_RS05975	COG2766	serine protein kinase
I533_RS05980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I533_RS05985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I533_RS05990	COG4771	TonB-dependent receptor
I533_RS06015	COG0450	alkyl hydroperoxide reductase
I533_RS06020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I533_RS06025	COG2885	chlorophyll binding
I533_RS06030	COG0584	glycerophosphoryl diester phosphodiesterase
I533_RS06035	COG0346	lactoylglutathione lyase activity
I533_RS06040	COG1278	Cold shock
I533_RS06060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I533_RS06065	COG4660	Part of a membrane complex involved in electron transport
I533_RS06070	COG4659	FMN binding
I533_RS06075	COG4658	electron transport chain
I533_RS06080	COG4656	Part of a membrane complex involved in electron transport
I533_RS06085	COG2878	Part of a membrane complex involved in electron transport
I533_RS06090	COG4657	Part of a membrane complex involved in electron transport
I533_RS06105	COG0534	Mate efflux family protein
I533_RS06110	COG0556	nucleotide-excision repair
I533_RS06125	COG0602	queuosine metabolic process
I533_RS06135	COG0367	asparagine synthase
I533_RS06160	COG3273	potassium ion transport
I533_RS06160	COG0471	metal ion transport
I533_RS06175	COG0529	Catalyzes the synthesis of activated sulfate
I533_RS06180	COG0175	sulfate reduction
I533_RS06185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I533_RS06190	COG2199	diguanylate cyclase activity
I533_RS06190	COG2203	Gaf domain
I533_RS06215	COG2304	oxidoreductase activity
I533_RS06235	COG0714	Associated with various cellular activities
I533_RS06245	COG1250	3-hydroxyacyl-CoA dehydrogenase
I533_RS06245	COG1024	Enoyl-CoA hydratase
I533_RS06260	COG1025	Belongs to the peptidase M16 family
I533_RS06265	COG2062	phosphohistidine phosphatase, SixA
I533_RS06275	COG4536	flavin adenine dinucleotide binding
I533_RS06280	COG4137	Cytochrome C assembly protein
I533_RS06285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I533_RS06335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I533_RS06340	COG1132	(ABC) transporter
I533_RS06355	COG0228	four-way junction DNA binding
I533_RS06360	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I533_RS06365	COG0336	Belongs to the RNA methyltransferase TrmD family
I533_RS06370	COG0335	large ribosomal subunit rRNA binding
I533_RS06375	COG2860	membrane
I533_RS06385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I533_RS06390	COG1605	Chorismate mutase
I533_RS06390	COG0287	Prephenate dehydrogenase
I533_RS06395	COG1605	Chorismate mutase
I533_RS06395	COG0077	Prephenate dehydratase
I533_RS06400	COG0745	RESPONSE REGULATOR receiver
I533_RS06405	COG0023	Translation Initiation Factor
I533_RS06435	COG2205	protein histidine kinase activity
I533_RS06445	COG2204	response regulator
I533_RS06465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I533_RS06470	COG0494	nUDIX hydrolase
I533_RS06475	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I533_RS06480	COG0632	four-way junction helicase activity
I533_RS06485	COG2255	four-way junction helicase activity
I533_RS06490	COG0824	Thioesterase
I533_RS06495	COG0811	peptide transport
I533_RS06510	COG0823	Involved in the tonB-independent uptake of proteins
I533_RS06515	COG2885	chlorophyll binding
I533_RS06520	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I533_RS06535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I533_RS06550	COG4667	esterase of the alpha-beta hydrolase superfamily
I533_RS06555	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I533_RS06580	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I533_RS06585	COG3038	cytochrome b561
I533_RS06605	COG0583	DNA-binding transcription factor activity
I533_RS06610	COG1451	nucleotide metabolic process
I533_RS06620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I533_RS06630	COG3706	GGDEF domain
I533_RS06640	COG3008	intermembrane lipid transfer
I533_RS06640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I533_RS06645	COG2995	paraquat-inducible protein a
I533_RS06660	COG0017	Asparaginyl-tRNA synthetase
I533_RS06675	COG0189	ligase activity
I533_RS06705	COG0156	8-amino-7-oxononanoate synthase activity
I533_RS06710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I533_RS06720	COG3340	Belongs to the peptidase S51 family
I533_RS06725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I533_RS06730	COG4139	cobalamin transport
I533_RS06735	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I533_RS06740	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I533_RS06755	COG5265	(ABC) transporter
I533_RS06760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I533_RS06770	COG0745	RESPONSE REGULATOR receiver
I533_RS06790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I533_RS06820	COG2755	lipolytic protein G-D-S-L family
I533_RS06825	COG4181	ATPase activity
I533_RS06830	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I533_RS06835	COG1090	epimerase
I533_RS06840	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I533_RS06845	COG0628	permease
I533_RS06870	COG2350	Protein conserved in bacteria
I533_RS06875	COG0159	tryptophan synthase activity
I533_RS06885	COG0135	phosphoribosylanthranilate isomerase activity
I533_RS06885	COG0134	indole-3-glycerol-phosphate synthase activity
I533_RS06890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I533_RS06900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I533_RS06905	COG0613	PHP domain protein
I533_RS06910	COG0009	L-threonylcarbamoyladenylate synthase
I533_RS06920	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I533_RS06930	COG0656	L-ascorbic acid biosynthetic process
I533_RS06935	COG0110	maltose O-acetyltransferase activity
I533_RS06945	COG2733	membrane
I533_RS06950	COG0500	methyltransferase
I533_RS06955	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I533_RS06960	COG0497	DNA recombination
I533_RS06965	COG0783	Belongs to the Dps family
I533_RS06970	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I533_RS06975	COG1454	alcohol dehydrogenase
I533_RS06980	COG1028	Short-chain dehydrogenase reductase Sdr
I533_RS06990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I533_RS06995	COG2610	gluconate transmembrane transporter activity
I533_RS07010	COG2205	protein histidine kinase activity
I533_RS07010	COG2198	Histidine kinase
I533_RS07010	COG0784	Response regulator, receiver
I533_RS07015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I533_RS07025	COG0484	heat shock protein binding
I533_RS07030	COG3909	cytochrome
I533_RS07035	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I533_RS07050	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I533_RS07060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I533_RS07065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I533_RS07075	COG0280	phosphate acetyltransferase
I533_RS07075	COG0857	belongs to the CobB CobQ family
I533_RS07090	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I533_RS07095	COG4535	Mg2 and Co2 transporter CorC
I533_RS07105	COG1702	phosphate starvation-inducible protein PhoH
I533_RS07115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I533_RS07145	COG1607	acyl-coa hydrolase
I533_RS07150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I533_RS07165	COG1115	amino acid carrier protein
I533_RS07200	COG0012	GTP binding
I533_RS07215	COG1064	alcohol dehydrogenase
I533_RS07230	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I533_RS07240	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I533_RS07245	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I533_RS07250	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I533_RS07260	COG2890	protein-(glutamine-N5) methyltransferase activity
I533_RS07265	COG3437	response regulator, receiver
I533_RS07265	COG0784	Response regulator, receiver
I533_RS07275	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I533_RS07285	COG0583	DNA-binding transcription factor activity
I533_RS07295	COG2363	Small membrane protein
I533_RS07310	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I533_RS07315	COG0515	serine threonine protein kinase
I533_RS07320	COG2116	formate transmembrane transporter activity
I533_RS07335	COG0714	Associated with various cellular activities
I533_RS07340	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I533_RS07345	COG0033	Phosphoglucomutase
I533_RS07350	COG0058	SHG alpha-glucan phosphorylase activity
I533_RS07360	COG2988	succinylglutamate desuccinylase activity
I533_RS07395	COG1393	Belongs to the ArsC family
I533_RS07420	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I533_RS07450	COG5001	Diguanylate cyclase
I533_RS07450	COG3300	MHYT domain
I533_RS07460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I533_RS07475	COG2249	NAD(P)H dehydrogenase (quinone) activity
I533_RS07495	COG1733	regulation of RNA biosynthetic process
I533_RS07500	COG5002	protein histidine kinase activity
I533_RS07500	COG5001	Diguanylate cyclase
I533_RS07500	COG3447	MASE1 domain protein
I533_RS07510	COG0402	S-adenosylhomocysteine deaminase activity
I533_RS07515	COG2351	hydroxyisourate hydrolase activity
I533_RS07530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I533_RS07545	COG1309	transcriptional regulator
I533_RS07560	COG2252	PERMEase
I533_RS07565	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I533_RS07580	COG5001	Diguanylate cyclase
I533_RS07580	COG4251	negative regulation of phosphorylation
I533_RS07580	COG3706	GGDEF domain
I533_RS07580	COG2203	Gaf domain
I533_RS07590	COG0784	Response regulator, receiver
I533_RS07590	COG2205	protein histidine kinase activity
I533_RS07600	COG2233	PERMEase
I533_RS07615	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I533_RS07620	COG0730	response to heat
I533_RS07660	COG1028	Short-chain dehydrogenase reductase Sdr
I533_RS07665	COG3001	Fructosamine kinase
I533_RS07675	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I533_RS07705	COG4774	siderophore transport
I533_RS07710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I533_RS07730	COG4464	protein tyrosine phosphatase activity
I533_RS07755	COG5001	Diguanylate cyclase
I533_RS07755	COG1716	ATPase activity
I533_RS07765	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I533_RS07775	COG0438	transferase activity, transferring glycosyl groups
I533_RS07790	COG0463	Glycosyl transferase, family 2
I533_RS07790	COG1216	Glycosyl transferase, family 2
I533_RS07825	COG2755	lipolytic protein G-D-S-L family
I533_RS07825	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I533_RS07830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I533_RS07865	COG1309	transcriptional regulator
I533_RS07875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I533_RS07875	COG0072	phenylalanine-tRNA ligase activity
I533_RS07900	COG1472	Belongs to the glycosyl hydrolase 3 family
I533_RS07905	COG2096	Adenosyltransferase
I533_RS07915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I533_RS07925	COG4591	ABC-type transport system involved in lipoprotein release permease component
I533_RS07950	COG0708	Exodeoxyribonuclease III
I533_RS07985	COG2814	Major facilitator Superfamily
I533_RS08020	COG4770	biotin carboxylase activity
I533_RS08025	COG1024	Enoyl-CoA hydratase
I533_RS08030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I533_RS08035	COG1960	acyl-CoA dehydrogenase activity
I533_RS08040	COG0789	Transcriptional regulator
I533_RS08045	COG0183	Belongs to the thiolase family
I533_RS08060	COG3706	GGDEF domain
I533_RS08070	COG2925	Exonuclease
I533_RS08120	COG1643	Atp-dependent helicase
I533_RS08140	COG0604	alcohol dehydrogenase
I533_RS08140	COG3321	synthase
I533_RS08145	COG0328	RNA-DNA hybrid ribonuclease activity
I533_RS08150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I533_RS08180	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I533_RS08185	COG1136	(ABC) transporter
I533_RS08190	COG4591	ABC-type transport system involved in lipoprotein release permease component
I533_RS08195	COG1301	dicarboxylic acid transport
I533_RS08205	COG3724	N-succinylarginine dihydrolase activity
I533_RS08210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I533_RS08225	COG0746	molybdenum cofactor guanylyltransferase activity
I533_RS08230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I533_RS08235	COG0243	molybdopterin cofactor binding
I533_RS08240	COG2153	protein acetylation
I533_RS08255	COG1530	ribonuclease E activity
I533_RS08260	COG0564	pseudouridine synthase activity
I533_RS08270	COG0424	maF-like protein
I533_RS08275	COG1399	metal-binding, possibly nucleic acid-binding protein
I533_RS08285	COG0416	fatty acid biosynthetic process
I533_RS08290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I533_RS08295	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I533_RS08305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I533_RS08310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I533_RS08320	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I533_RS08335	COG0084	hydrolase, TatD family'
I533_RS08345	COG0702	epimerase
I533_RS08350	COG3706	GGDEF domain
I533_RS08370	COG1028	Short-chain dehydrogenase reductase Sdr
I533_RS08375	COG0596	Alpha beta hydrolase
I533_RS08385	COG0183	Belongs to the thiolase family
I533_RS08390	COG1960	acyl-CoA dehydrogenase activity
I533_RS08410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I533_RS08420	COG0246	Mannitol dehydrogenase
I533_RS08440	COG0668	transmembrane transport
I533_RS08445	COG4771	TonB-dependent receptor
I533_RS08465	COG2205	protein histidine kinase activity
I533_RS08465	COG2198	Histidine kinase
I533_RS08465	COG0784	Response regulator, receiver
I533_RS08470	COG3437	response regulator, receiver
I533_RS08480	COG0195	Participates in both transcription termination and antitermination
I533_RS08495	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I533_RS08510	COG1187	pseudouridine synthase activity
I533_RS08520	COG3153	acetyltransferase
I533_RS08520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I533_RS08590	COG1032	radical SAM domain protein
I533_RS08610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I533_RS08620	COG4134	Bacterial extracellular solute-binding protein
I533_RS08630	COG4136	ATPase activity
I533_RS08635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I533_RS08660	COG5001	Diguanylate cyclase
I533_RS08660	COG4251	negative regulation of phosphorylation
I533_RS08660	COG2203	Gaf domain
I533_RS08660	COG3706	GGDEF domain
I533_RS08700	COG1131	(ABC) transporter
I533_RS08715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I533_RS08720	COG0385	Bile acid
I533_RS08740	COG1902	pentaerythritol trinitrate reductase activity
I533_RS08750	COG2867	negative regulation of translational initiation
I533_RS08755	COG2914	Belongs to the UPF0125 (RnfH) family
I533_RS08765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I533_RS08770	COG4771	TonB-dependent receptor
I533_RS08775	COG0457	Tetratricopeptide repeat
I533_RS08790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I533_RS08790	COG0574	Belongs to the PEP-utilizing enzyme family
I533_RS08825	COG2850	peptidyl-arginine hydroxylation
I533_RS08835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I533_RS08840	COG2915	High frequency lysogenization protein hflD homolog
I533_RS08845	COG0482	sulfurtransferase activity
I533_RS08850	COG1187	pseudouridine synthase activity
I533_RS08860	COG1278	Cold shock
I533_RS08865	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I533_RS08870	COG0542	response to heat
I533_RS08875	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I533_RS08880	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I533_RS08885	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I533_RS08890	COG0492	ferredoxin-NADP+ reductase activity
I533_RS08900	COG3091	SprT-like family
I533_RS08905	COG0616	signal peptide processing
I533_RS08920	COG0778	Nitroreductase
I533_RS08930	COG0252	asparaginase activity
I533_RS08935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I533_RS08940	COG0321	lipoyl(octanoyl) transferase activity
I533_RS08945	COG2921	Belongs to the UPF0250 family
I533_RS08950	COG1686	Belongs to the peptidase S11 family
I533_RS08955	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I533_RS08960	COG0772	Belongs to the SEDS family
I533_RS08965	COG0768	penicillin binding
I533_RS08970	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I533_RS08975	COG0799	negative regulation of ribosome biogenesis
I533_RS08985	COG1466	dna polymerase III delta subunit
I533_RS08990	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I533_RS08995	COG0495	leucyl-tRNA aminoacylation
I533_RS09010	COG1067	ATP-dependent peptidase activity
I533_RS09015	COG0596	Alpha beta hydrolase
I533_RS09020	COG2199	diguanylate cyclase activity
I533_RS09020	COG2203	Gaf domain
I533_RS09030	COG1534	Rna-binding protein
I533_RS09035	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I533_RS09040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I533_RS09045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I533_RS09050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I533_RS09055	COG0149	triose-phosphate isomerase activity
I533_RS09060	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I533_RS09080	COG1028	Short-chain dehydrogenase reductase Sdr
I533_RS09085	COG0561	phosphatase activity
I533_RS09100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I533_RS09105	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I533_RS09110	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I533_RS09125	COG1185	polyribonucleotide nucleotidyltransferase activity
I533_RS09155	COG2856	Zn peptidase
I533_RS09285	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I533_RS09290	COG1196	nuclear chromosome segregation
I533_RS09300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I533_RS09315	COG1132	(ABC) transporter
I533_RS09320	COG1663	tetraacyldisaccharide 4'-kinase activity
I533_RS09355	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I533_RS09360	COG0435	Glutathione S-transferase
I533_RS09365	COG1741	Belongs to the pirin family
I533_RS09370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I533_RS09380	COG0372	Belongs to the citrate synthase family
I533_RS09390	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I533_RS09395	COG1053	succinate dehydrogenase
I533_RS09400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I533_RS09405	COG0567	Dehydrogenase, E1 component
I533_RS09410	COG0508	dehydrogenase complex catalyzes the overall conversion of
I533_RS09445	COG4667	esterase of the alpha-beta hydrolase superfamily
I533_RS09465	COG0366	Alpha amylase catalytic
I533_RS09490	COG1028	Short-chain dehydrogenase reductase Sdr
I533_RS09495	COG2267	carboxylic ester hydrolase activity
I533_RS09505	COG0616	signal peptide processing
I533_RS09525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I533_RS09530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I533_RS09535	COG0386	Belongs to the glutathione peroxidase family
I533_RS09540	COG2084	Dehydrogenase
I533_RS09550	COG1960	acyl-CoA dehydrogenase activity
I533_RS09555	COG1024	Enoyl-CoA hydratase
I533_RS09560	COG2226	methyltransferase
I533_RS09570	COG3083	sulfuric ester hydrolase activity
I533_RS09575	COG3082	Protein of unknown function (DUF1414)
I533_RS09580	COG3081	Nucleoid-associated protein
I533_RS09610	COG3275	phosphorelay sensor kinase activity
I533_RS09615	COG3279	Response regulator of the LytR AlgR family
I533_RS09620	COG0205	6-phosphofructokinase activity
I533_RS09650	COG0604	alcohol dehydrogenase
I533_RS09650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I533_RS09650	COG3321	synthase
I533_RS09650	COG4221	oxidoreductase activity
I533_RS09655	COG4221	oxidoreductase activity
I533_RS09660	COG0583	DNA-binding transcription factor activity
I533_RS09710	COG2205	protein histidine kinase activity
I533_RS09710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I533_RS09720	COG1054	Belongs to the UPF0176 family
I533_RS09730	COG0513	Belongs to the DEAD box helicase family
I533_RS09740	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I533_RS09745	COG0583	DNA-binding transcription factor activity
I533_RS09765	COG1760	l-serine dehydratase
I533_RS09790	COG1322	Protein conserved in bacteria
I533_RS09795	COG1404	Belongs to the peptidase S8 family
I533_RS09800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I533_RS09805	COG0022	dehydrogenase e1 component
I533_RS09815	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I533_RS09820	COG0515	serine threonine protein kinase
I533_RS09825	COG1946	Acyl-CoA thioesterase
I533_RS09835	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I533_RS09845	COG1956	GAF domain-containing protein
I533_RS09860	COG0793	Belongs to the peptidase S41A family
I533_RS09865	COG0733	neurotransmitter:sodium symporter activity
I533_RS09870	COG1757	Na H antiporter
I533_RS09875	COG0308	aminopeptidase N
I533_RS09905	COG2902	Dehydrogenase
I533_RS09910	COG0167	dihydroorotate dehydrogenase activity
I533_RS09925	COG0488	(ABC) transporter
I533_RS09935	COG3130	regulation of translation
I533_RS09940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I533_RS09950	COG0415	Belongs to the DNA photolyase family
I533_RS09955	COG0415	Belongs to the DNA photolyase family
I533_RS09960	COG0415	Belongs to the DNA photolyase family
I533_RS09965	COG3046	protein related to deoxyribodipyrimidine photolyase
I533_RS09975	COG4974	Belongs to the 'phage' integrase family
I533_RS09985	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I533_RS09990	COG0589	response to stress
I533_RS10000	COG0069	glutamate synthase activity
I533_RS10015	COG2193	ferroxidase activity
I533_RS10025	COG3278	Belongs to the heme-copper respiratory oxidase family
I533_RS10040	COG2010	Cytochrome c
I533_RS10050	COG2217	Heavy metal translocating P-type atpase
I533_RS10065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I533_RS10070	COG0589	response to stress
I533_RS10075	COG0037	tRNA processing
I533_RS10080	COG1752	Esterase of the alpha-beta hydrolase superfamily
I533_RS10100	COG1280	lysine exporter protein (LysE YggA)
I533_RS10110	COG2897	thiosulfate sulfurtransferase activity
I533_RS10115	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I533_RS10120	COG3148	PFAM DTW domain containing protein
I533_RS10145	COG0322	excinuclease ABC activity
I533_RS10150	COG2197	response regulator
I533_RS10155	COG0436	Aminotransferase
I533_RS10160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I533_RS10185	COG0556	nucleotide-excision repair
I533_RS10190	COG4974	Belongs to the 'phage' integrase family
I533_RS10225	COG0789	Transcriptional regulator
I533_RS10230	COG3547	Transposase (IS116 IS110 IS902 family)
I533_RS10240	COG2259	Doxx family
I533_RS10245	COG0583	DNA-binding transcription factor activity
I533_RS10260	COG0670	Belongs to the BI1 family
I533_RS10265	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I533_RS10280	COG2920	part of a sulfur-relay system
I533_RS10305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I533_RS10315	COG0531	amino acid
I533_RS10315	COG1674	ftsk spoiiie
I533_RS10325	COG0686	Belongs to the AlaDH PNT family
I533_RS10330	COG0284	orotidine-5'-phosphate decarboxylase activity
I533_RS10335	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I533_RS10350	COG0776	regulation of translation
I533_RS10355	COG0539	negative regulation of cytoplasmic translation
I533_RS10360	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I533_RS10365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I533_RS10370	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I533_RS10380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I533_RS10385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I533_RS10390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I533_RS10395	COG0633	Ferredoxin
I533_RS10430	COG3344	reverse transcriptase
I533_RS10440	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I533_RS10445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I533_RS10455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I533_RS10465	COG4783	chaperone-mediated protein folding
I533_RS10475	COG1393	Belongs to the ArsC family
I533_RS10490	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I533_RS10505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I533_RS10515	COG1960	acyl-CoA dehydrogenase activity
I533_RS10540	COG0572	uridine kinase
I533_RS10545	COG3769	mannosylglycerate metabolic process
I533_RS10550	COG1215	transferase activity, transferring glycosyl groups
I533_RS10555	COG0366	Alpha amylase catalytic
I533_RS10565	COG0303	'Molybdopterin
I533_RS10570	COG0534	Mate efflux family protein
I533_RS10585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I533_RS10590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I533_RS10610	COG3547	Transposase (IS116 IS110 IS902 family)
I533_RS10630	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I533_RS10650	COG3547	Transposase (IS116 IS110 IS902 family)
I533_RS10675	COG0405	Gamma-glutamyltransferase
I533_RS10680	COG1024	Enoyl-CoA hydratase
I533_RS10725	COG1448	Aminotransferase
I533_RS10740	COG1671	Belongs to the UPF0178 family
I533_RS10745	COG1028	Short-chain dehydrogenase reductase Sdr
I533_RS10750	COG1028	Short-chain dehydrogenase reductase Sdr
I533_RS10755	COG1960	acyl-CoA dehydrogenase activity
I533_RS10760	COG0662	Cupin 2, conserved barrel domain protein
I533_RS10760	COG2207	Transcriptional regulator
I533_RS10775	COG1505	serine-type exopeptidase activity
I533_RS10785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I533_RS10815	COG0596	Alpha beta hydrolase
I533_RS10825	COG0716	FMN binding
I533_RS10850	COG4772	TonB-dependent receptor
I533_RS10860	COG0735	belongs to the Fur family
I533_RS10870	COG1984	allophanate hydrolase subunit 2
I533_RS10875	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I533_RS10880	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I533_RS10885	COG2996	Protein conserved in bacteria
I533_RS10890	COG1765	OsmC-like protein
I533_RS10895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I533_RS10905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I533_RS10920	COG0436	Aminotransferase
I533_RS10925	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I533_RS10930	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I533_RS10940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I533_RS10940	COG2010	Cytochrome c
I533_RS10970	COG1073	alpha beta
I533_RS10975	COG2207	Transcriptional regulator
I533_RS10985	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I533_RS10990	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I533_RS11015	COG3012	SEC-C Motif Domain Protein
I533_RS11020	COG0604	alcohol dehydrogenase
I533_RS11030	COG1960	acyl-CoA dehydrogenase activity
I533_RS11040	COG4771	TonB-dependent receptor
I533_RS11065	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I533_RS11085	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I533_RS11090	COG0315	cyclic pyranopterin monophosphate synthase activity
I533_RS11095	COG0521	Mo-molybdopterin cofactor biosynthetic process
I533_RS11110	COG2161	toxin-antitoxin pair type II binding
I533_RS11115	COG4115	mRNA cleavage
I533_RS11130	COG0436	Aminotransferase
I533_RS11135	COG3268	Saccharopine dehydrogenase
I533_RS11140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I533_RS11155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I533_RS11160	COG4206	TonB-dependent receptor
I533_RS11170	COG5006	permease, DMT superfamily
I533_RS11185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I533_RS11190	COG1074	ATP-dependent DNA helicase activity
I533_RS11195	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I533_RS11210	COG1022	Amp-dependent synthetase and ligase
I533_RS11215	COG4251	negative regulation of phosphorylation
I533_RS11215	COG3706	GGDEF domain
I533_RS11215	COG2203	Gaf domain
I533_RS11215	COG5001	Diguanylate cyclase
I533_RS11235	COG0583	DNA-binding transcription factor activity
I533_RS11250	COG0640	Transcriptional regulator
I533_RS11270	COG2204	response regulator
I533_RS11280	COG4251	negative regulation of phosphorylation
I533_RS11285	COG0784	Response regulator, receiver
I533_RS11290	COG0784	Response regulator, receiver
I533_RS11290	COG2205	protein histidine kinase activity
I533_RS11315	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I533_RS11340	COG3139	Protein of unknown function (DUF1315)
I533_RS11355	COG1115	amino acid carrier protein
I533_RS11360	COG2866	Carboxypeptidase
I533_RS11380	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I533_RS11390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I533_RS11395	COG1640	4-alpha-glucanotransferase
I533_RS11400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I533_RS11405	COG0676	glucose-6-phosphate 1-epimerase activity
I533_RS11410	COG0800	Aldolase
I533_RS11420	COG0129	dihydroxy-acid dehydratase activity
I533_RS11430	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I533_RS11435	COG1737	Transcriptional regulator
I533_RS11440	COG0469	pyruvate kinase activity
I533_RS11455	COG1960	acyl-CoA dehydrogenase activity
I533_RS11475	COG0471	metal ion transport
I533_RS11475	COG0490	domain, Protein
I533_RS11495	COG0129	dihydroxy-acid dehydratase activity
I533_RS11505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I533_RS11510	COG1737	Transcriptional regulator
I533_RS11515	COG0469	pyruvate kinase activity
I533_RS11520	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I533_RS11540	COG2823	Periplasmic or secreted lipoprotein
I533_RS11570	COG3665	Urea carboxylase-associated protein
I533_RS11600	COG2356	endonuclease I
I533_RS11620	COG0583	DNA-binding transcription factor activity
I533_RS11625	COG1979	alcohol dehydrogenase
I533_RS11640	COG3437	response regulator, receiver
I533_RS11640	COG0784	Response regulator, receiver
I533_RS11660	COG0471	metal ion transport
I533_RS11670	COG0489	protein tyrosine kinase activity
I533_RS11675	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I533_RS11675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I533_RS11680	COG0668	transmembrane transport
I533_RS11685	COG2226	methyltransferase
I533_RS11690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I533_RS11695	COG1388	LysM domain
I533_RS11695	COG0741	lytic transglycosylase activity
I533_RS11705	COG0215	cysteine-tRNA ligase activity
I533_RS11710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I533_RS11715	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I533_RS11725	COG2268	Band 7 protein
I533_RS11740	COG1733	regulation of RNA biosynthetic process
I533_RS11745	COG0604	alcohol dehydrogenase
I533_RS11750	COG0753	catalase activity
I533_RS11755	COG0604	alcohol dehydrogenase
I533_RS11795	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I533_RS11800	COG1286	toxin biosynthetic process
I533_RS11805	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I533_RS11810	COG0285	dihydrofolate synthase activity
I533_RS11830	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I533_RS11835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I533_RS11855	COG3609	addiction module antidote protein, CC2985 family
I533_RS11865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I533_RS11875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I533_RS11875	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I533_RS11920	COG0789	Transcriptional regulator
I533_RS11925	COG0604	alcohol dehydrogenase
I533_RS11940	COG1119	ATPase activity
I533_RS11945	COG2031	fatty acid transporter
I533_RS11950	COG0784	Response regulator, receiver
I533_RS11950	COG5002	protein histidine kinase activity
I533_RS11950	COG2205	protein histidine kinase activity
I533_RS11960	COG0612	Peptidase, M16
I533_RS11975	COG3101	peptidyl-lysine hydroxylation
I533_RS12000	COG0446	pyridine nucleotide-disulphide oxidoreductase
I533_RS12000	COG1902	pentaerythritol trinitrate reductase activity
I533_RS12025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I533_RS12035	COG4399	Belongs to the UPF0754 family
I533_RS12060	COG1770	oligopeptidase
I533_RS12065	COG2186	Transcriptional regulator
I533_RS12075	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I533_RS12080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I533_RS12090	COG2983	Belongs to the UPF0260 family
I533_RS12095	COG0179	Fumarylacetoacetate (FAA) hydrolase
I533_RS12110	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I533_RS12115	COG0318	PFAM AMP-dependent synthetase and ligase
I533_RS12120	COG2267	carboxylic ester hydrolase activity
I533_RS12135	COG1214	PFAM Peptidase M22, glycoprotease
I533_RS12140	COG1199	ATP-dependent helicase activity
I533_RS12190	COG4771	TonB-dependent receptor
I533_RS12200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I533_RS12205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I533_RS12210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I533_RS12215	COG0131	Imidazoleglycerol-phosphate dehydratase
I533_RS12215	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I533_RS12220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I533_RS12235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I533_RS12235	COG0140	phosphoribosyl-ATP diphosphatase activity
I533_RS12240	COG2116	formate transmembrane transporter activity
I533_RS12245	COG0840	transmembrane signaling receptor activity
I533_RS12280	COG0326	Molecular chaperone. Has ATPase activity
I533_RS12285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I533_RS12305	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I533_RS12310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I533_RS12320	COG3220	belongs to the UPF0276 family
I533_RS12330	COG0577	efflux transmembrane transporter activity
I533_RS12330	COG1136	(ABC) transporter
I533_RS12340	COG5001	Diguanylate cyclase
I533_RS12340	COG4251	negative regulation of phosphorylation
I533_RS12340	COG3706	GGDEF domain
I533_RS12340	COG2203	Gaf domain
I533_RS12375	COG1183	phosphatidylcholine synthase activity
I533_RS12395	COG0277	FAD linked oxidase domain protein
I533_RS12400	COG0542	response to heat
I533_RS12425	COG1595	DNA-templated transcription, initiation
I533_RS12440	COG4221	oxidoreductase activity
I533_RS12455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I533_RS12465	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I533_RS12475	COG0142	geranyltranstransferase activity
I533_RS12485	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I533_RS12490	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I533_RS12500	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I533_RS12515	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I533_RS12515	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I533_RS12530	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I533_RS12535	COG0488	(ABC) transporter
I533_RS12545	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I533_RS12555	COG0560	Phosphoserine phosphatase
I533_RS12565	COG0084	hydrolase, TatD family'
I533_RS12580	COG0571	ribonuclease III activity
I533_RS12610	COG1595	DNA-templated transcription, initiation
I533_RS12615	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I533_RS12630	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I533_RS12710	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I533_RS12715	COG1047	Peptidyl-prolyl cis-trans
I533_RS12725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I533_RS12730	COG0196	riboflavin kinase activity
I533_RS12735	COG0728	peptidoglycan biosynthetic process
I533_RS12740	COG0268	Binds directly to 16S ribosomal RNA
I533_RS12755	COG1028	Short-chain dehydrogenase reductase Sdr
I533_RS12760	COG0385	Bile acid
I533_RS12765	COG0583	DNA-binding transcription factor activity
I533_RS12790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I533_RS12795	COG0776	regulation of translation
I533_RS12805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I533_RS12810	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I533_RS12815	COG0740	serine-type endopeptidase activity
I533_RS12820	COG0544	peptidyl-prolyl cis-trans isomerase activity
I533_RS12865	COG1720	tRNA m6t6A37 methyltransferase activity
I533_RS12875	COG1234	tRNA 3'-trailer cleavage
I533_RS12885	COG0123	including yeast histone deacetylase and acetoin utilization protein
I533_RS12900	COG0516	GMP reductase activity
I533_RS12900	COG0517	IMP dehydrogenase activity
I533_RS12905	COG1570	exodeoxyribonuclease VII activity
I533_RS12925	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I533_RS12930	COG2976	Protein conserved in bacteria
I533_RS12955	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I533_RS12965	COG2166	iron-sulfur cluster assembly
I533_RS12980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I533_RS12985	COG0719	Fe-S assembly protein
I533_RS12990	COG0396	ATPase activity
I533_RS12995	COG0719	Fe-S assembly protein
I533_RS13000	COG1104	cysteine desulfurase activity
I533_RS13010	COG2072	flavoprotein involved in K transport
I533_RS13015	COG1045	serine acetyltransferase
I533_RS13020	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I533_RS13025	COG0483	inositol monophosphate 1-phosphatase activity
I533_RS13040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I533_RS13045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I533_RS13050	COG1862	Preprotein translocase
I533_RS13055	COG0343	queuine tRNA-ribosyltransferase activity
I533_RS13075	COG1842	Phage shock protein A
I533_RS13080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I533_RS13100	COG0754	glutathionylspermidine amidase activity
I533_RS13130	COG2066	Belongs to the glutaminase family
I533_RS13135	COG1785	Belongs to the alkaline phosphatase family
I533_RS13140	COG0745	RESPONSE REGULATOR receiver
I533_RS13175	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I533_RS13280	COG0438	transferase activity, transferring glycosyl groups
I533_RS13305	COG0438	transferase activity, transferring glycosyl groups
I533_RS13330	COG0367	asparagine synthase
I533_RS13335	COG0438	transferase activity, transferring glycosyl groups
I533_RS13355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I533_RS13370	COG0489	protein tyrosine kinase activity
I533_RS13380	COG3409	Peptidoglycan-binding domain 1 protein
I533_RS13380	COG3267	Type II secretory pathway component ExeA
I533_RS13385	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I533_RS13385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I533_RS13390	COG2827	Endonuclease containing a URI domain
I533_RS13415	COG1560	Kdo2-lipid A biosynthetic process
I533_RS13445	COG1960	acyl-CoA dehydrogenase activity
I533_RS13460	COG3300	MHYT domain
I533_RS13460	COG5001	Diguanylate cyclase
I533_RS13465	COG1435	thymidine kinase activity
I533_RS13475	COG1609	Transcriptional regulator
I533_RS13480	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I533_RS13505	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I533_RS13510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I533_RS13515	COG1250	3-hydroxyacyl-CoA dehydrogenase
I533_RS13515	COG1024	Enoyl-CoA hydratase
I533_RS13530	COG1012	belongs to the aldehyde dehydrogenase family
I533_RS13550	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I533_RS13575	COG1960	acyl-CoA dehydrogenase activity
I533_RS13605	COG0745	RESPONSE REGULATOR receiver
I533_RS13610	COG2205	protein histidine kinase activity
I533_RS13650	COG2080	2 iron, 2 sulfur cluster binding
I533_RS13655	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I533_RS13660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I533_RS13680	COG1028	Short-chain dehydrogenase reductase Sdr
I533_RS13690	COG4221	oxidoreductase activity
I533_RS13695	COG0693	protein deglycase activity
I533_RS13700	COG1295	ribonuclease BN
I533_RS13740	COG2814	Major facilitator Superfamily
I533_RS13755	COG0514	ATP-dependent DNA helicase (RecQ)
I533_RS13785	COG4251	negative regulation of phosphorylation
I533_RS13790	COG2133	pyrroloquinoline quinone binding
I533_RS13805	COG0830	nickel cation binding
I533_RS13830	COG0829	nickel cation binding
I533_RS13870	COG0745	RESPONSE REGULATOR receiver
I533_RS13875	COG3177	Filamentation induced by cAMP protein fic
I533_RS13895	COG4942	peptidase
I533_RS13905	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I533_RS13925	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I533_RS13935	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I533_RS13935	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I533_RS13950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I533_RS13955	COG2971	BadF BadG BcrA BcrD
I533_RS13960	COG0583	DNA-binding transcription factor activity
I533_RS13965	COG1620	l-lactate permease
I533_RS13985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I533_RS13990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I533_RS13995	COG0006	proline dipeptidase activity
I533_RS14005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I533_RS14020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I533_RS14025	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I533_RS14030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I533_RS14050	COG3313	Fe-S protein
I533_RS14085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I533_RS14090	COG0508	dehydrogenase complex catalyzes the overall conversion of
I533_RS14095	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I533_RS14110	COG3023	N-Acetylmuramoyl-L-alanine amidase
I533_RS14115	COG3577	Aspartyl protease
I533_RS14120	COG0157	Belongs to the NadC ModD family
I533_RS14130	COG1459	type II secretion system
I533_RS14135	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I533_RS14140	COG0237	dephospho-CoA kinase activity
I533_RS14140	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I533_RS14145	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I533_RS14150	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I533_RS14155	COG3608	succinylglutamate desuccinylase aspartoacylase
I533_RS14160	COG0494	nUDIX hydrolase
I533_RS14170	COG0739	heme binding
I533_RS14175	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I533_RS14180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I533_RS14185	COG0849	cell division
I533_RS14190	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I533_RS14195	COG1181	Belongs to the D-alanine--D-alanine ligase family
I533_RS14200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I533_RS14210	COG0772	Belongs to the SEDS family
I533_RS14215	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I533_RS14225	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I533_RS14230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I533_RS14235	COG0768	penicillin binding
I533_RS14240	COG3116	cell division
I533_RS14250	COG2001	Belongs to the MraZ family
I533_RS14290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I533_RS14290	COG0678	peroxiredoxin activity
I533_RS14320	COG2205	protein histidine kinase activity
I533_RS14320	COG0784	Response regulator, receiver
I533_RS14345	COG0668	transmembrane transport
I533_RS14350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I533_RS14355	COG0189	ligase activity
I533_RS14360	COG1678	Uncharacterized ACR, COG1678
I533_RS14365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I533_RS14390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I533_RS14395	COG0762	integral membrane protein
I533_RS14405	COG0446	pyridine nucleotide-disulphide oxidoreductase
I533_RS14405	COG1902	pentaerythritol trinitrate reductase activity
I533_RS14420	COG0625	glutathione transferase activity
I533_RS14430	COG1764	response to oxidative stress
I533_RS14435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I533_RS14450	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I533_RS14460	COG2814	Major facilitator Superfamily
I533_RS14465	COG0724	RNA recognition motif
I533_RS14490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I533_RS14495	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I533_RS14500	COG0083	homoserine kinase activity
I533_RS14515	COG0583	DNA-binding transcription factor activity
I533_RS14530	COG0640	Transcriptional regulator
I533_RS14540	COG0431	NADPH-dependent FMN reductase
I533_RS14545	COG0798	PFAM Bile acid sodium symporter
I533_RS14550	COG2201	protein-glutamate methylesterase activity
I533_RS14555	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I533_RS14565	COG0642	Histidine kinase
I533_RS14590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I533_RS14615	COG1748	Saccharopine dehydrogenase
I533_RS14630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I533_RS14635	COG3107	peptidoglycan biosynthetic process
I533_RS14645	COG0438	transferase activity, transferring glycosyl groups
I533_RS14655	COG2823	Periplasmic or secreted lipoprotein
I533_RS14675	COG4585	Histidine kinase
I533_RS14680	COG2197	response regulator
I533_RS14695	COG4771	TonB-dependent receptor
I533_RS14705	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I533_RS14710	COG0372	Belongs to the citrate synthase family
I533_RS14715	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I533_RS14720	COG2828	Protein conserved in bacteria
I533_RS14725	COG2203	Gaf domain
I533_RS14725	COG2199	diguanylate cyclase activity
I533_RS14745	COG5002	protein histidine kinase activity
I533_RS14745	COG2198	Histidine kinase
I533_RS14745	COG0784	Response regulator, receiver
I533_RS14750	COG3023	N-Acetylmuramoyl-L-alanine amidase
I533_RS14755	COG0067	glutamate synthase
I533_RS14755	COG0070	glutamate synthase
I533_RS14755	COG0069	glutamate synthase activity
I533_RS14760	COG0493	'glutamate synthase
I533_RS14775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I533_RS14780	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I533_RS14790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I533_RS14805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I533_RS14810	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I533_RS14820	COG4942	peptidase
I533_RS14825	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I533_RS14830	COG0738	Major facilitator superfamily
I533_RS14840	COG1902	pentaerythritol trinitrate reductase activity
I533_RS14860	COG0625	glutathione transferase activity
I533_RS14885	COG2894	cell division
I533_RS14890	COG0850	regulation of cytokinetic process
I533_RS14900	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I533_RS14915	COG1981	membrane
I533_RS14930	COG1914	H( )-stimulated, divalent metal cation uptake system
I533_RS14945	COG1217	gtp-binding protein TYPA
I533_RS14950	COG0174	glutamine synthetase
I533_RS14960	COG3852	Histidine kinase
I533_RS14965	COG2204	response regulator
I533_RS14970	COG3437	response regulator, receiver
I533_RS15010	COG2205	protein histidine kinase activity
I533_RS15010	COG3437	response regulator, receiver
I533_RS15010	COG3850	Histidine kinase
I533_RS15010	COG4999	Histidine kinase
I533_RS15015	COG0525	valine-tRNA ligase activity
I533_RS15020	COG2927	DNA polymerase III (CHI subunit)
I533_RS15025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I533_RS15030	COG0795	lipopolysaccharide-transporting ATPase activity
I533_RS15035	COG0795	lipopolysaccharide-transporting ATPase activity
I533_RS15110	COG2856	Zn peptidase
I533_RS15200	COG0673	inositol 2-dehydrogenase activity
I533_RS15215	COG0628	permease
I533_RS15230	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I533_RS15235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I533_RS15240	COG4558	Periplasmic binding protein
I533_RS15250	COG4206	TonB-dependent receptor
I533_RS15265	COG0149	triose-phosphate isomerase activity
I533_RS15270	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I533_RS15275	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I533_RS15285	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I533_RS15290	COG3842	ATPase activity
I533_RS15325	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I533_RS15360	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I533_RS15375	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I533_RS15385	COG0679	Auxin Efflux Carrier
I533_RS15420	COG1131	(ABC) transporter
I533_RS15440	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I533_RS15480	COG2205	protein histidine kinase activity
I533_RS15490	COG0348	domain, Protein
I533_RS15490	COG3901	Regulator of nitric oxide reductase transcription
I533_RS15500	COG2197	response regulator
I533_RS15525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I533_RS15530	COG0277	FAD linked oxidase domain protein
I533_RS15540	COG1462	curli production assembly transport component CsgG
I533_RS15570	COG2197	response regulator
I533_RS15585	COG0513	Belongs to the DEAD box helicase family
I533_RS15590	COG5001	Diguanylate cyclase
I533_RS15605	COG0800	Aldolase
I533_RS15610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I533_RS15625	COG3264	Mechanosensitive ion channel
I533_RS15625	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I533_RS15665	COG0730	response to heat
I533_RS15670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I533_RS15685	COG4191	Histidine kinase
I533_RS15695	COG0417	DNA replication proofreading
I533_RS15705	COG0318	PFAM AMP-dependent synthetase and ligase
I533_RS15750	COG1309	transcriptional regulator
I533_RS15760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I533_RS15770	COG1573	uracil-dna glycosylase
I533_RS15775	COG5001	Diguanylate cyclase
I533_RS15775	COG3300	MHYT domain
I533_RS15795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I533_RS15815	COG1983	PspC domain protein
I533_RS15820	COG1842	Phage shock protein A
I533_RS15830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I533_RS15855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I533_RS15865	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I533_RS15870	COG0204	Acyl-transferase
I533_RS15875	COG0204	Acyl-transferase
I533_RS15880	COG0668	transmembrane transport
I533_RS15895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I533_RS15900	COG0733	neurotransmitter:sodium symporter activity
I533_RS15915	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I533_RS15940	COG0848	biopolymer transport protein
I533_RS15960	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I533_RS15970	COG1215	transferase activity, transferring glycosyl groups
I533_RS15985	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I533_RS15990	COG0702	epimerase
I533_RS16015	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I533_RS16025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I533_RS16035	COG0583	DNA-binding transcription factor activity
I533_RS16040	COG0121	glutamine amidotransferase
I533_RS16045	COG4682	membrane
I533_RS16065	COG1953	Uracil, thiamine, allantoin
I533_RS16070	COG4771	TonB-dependent receptor
I533_RS16080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I533_RS16085	COG0778	Nitroreductase
I533_RS16090	COG0596	Alpha beta hydrolase
I533_RS16095	COG0251	oxidation-reduction process
I533_RS16100	COG1335	isochorismatase
I533_RS16105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I533_RS16110	COG1309	transcriptional regulator
I533_RS16125	COG4628	conserved protein (DUF2132)
I533_RS16145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I533_RS16150	COG1609	Transcriptional regulator
I533_RS16155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I533_RS16165	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I533_RS16175	COG1477	protein flavinylation
I533_RS16180	COG2871	sodium ion transport
I533_RS16185	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I533_RS16190	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I533_RS16195	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I533_RS16200	COG1805	sodium ion transport
I533_RS16205	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I533_RS16210	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I533_RS16215	COG0545	Peptidyl-prolyl cis-trans isomerase
I533_RS16220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I533_RS16235	COG0039	L-malate dehydrogenase activity
I533_RS16240	COG1438	arginine binding
I533_RS16265	COG0572	uridine kinase
I533_RS16270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I533_RS16295	COG2176	DNA-directed DNA polymerase activity
I533_RS16305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I533_RS16325	COG0189	ligase activity
I533_RS16335	COG0189	ligase activity
I533_RS16335	COG4067	protein conserved in archaea
I533_RS16350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I533_RS16360	COG1283	sodium-dependent phosphate transmembrane transporter activity
I533_RS16365	COG0667	Aldo Keto reductase
I533_RS16420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I533_RS16430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I533_RS16435	COG0840	transmembrane signaling receptor activity
I533_RS16475	COG2274	protein secretion by the type I secretion system
I533_RS16480	COG0583	DNA-binding transcription factor activity
I533_RS16505	COG1091	dTDP-4-dehydrorhamnose reductase activity
I533_RS16535	COG1051	belongs to the nudix hydrolase family
I533_RS16540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I533_RS16570	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I533_RS16640	COG0110	maltose O-acetyltransferase activity
I533_RS16730	COG0438	transferase activity, transferring glycosyl groups
I533_RS16730	COG1216	Glycosyl transferase, family 2
I533_RS16755	COG2161	toxin-antitoxin pair type II binding
I533_RS16765	COG0202	RNA polymerase activity
I533_RS16790	COG0201	protein transport
I533_RS16810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I533_RS16845	COG5002	protein histidine kinase activity
I533_RS16845	COG0784	Response regulator, receiver
I533_RS16865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I533_RS16870	COG0557	exoribonuclease II activity
I533_RS16900	COG4771	TonB-dependent receptor
I533_RS16915	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I533_RS16930	COG0543	2 iron, 2 sulfur cluster binding
I533_RS16945	COG2234	aminopeptidase activity
I533_RS16955	COG4251	negative regulation of phosphorylation
I533_RS16965	COG1271	oxidase subunit
I533_RS16970	COG1294	oxidase, subunit
I533_RS16975	COG1522	sequence-specific DNA binding
I533_RS16985	COG1278	Cold shock
I533_RS16990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I533_RS17010	COG0339	signal peptide processing
I533_RS17015	COG2201	protein-glutamate methylesterase activity
I533_RS17025	COG3852	Histidine kinase
I533_RS17035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I533_RS17040	COG0243	molybdopterin cofactor binding
I533_RS17045	COG0823	Involved in the tonB-independent uptake of proteins
I533_RS17045	COG1506	peptidase
I533_RS17045	COG4946	Tricorn protease homolog
I533_RS17090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I533_RS17100	COG2197	response regulator
I533_RS17110	COG0189	ligase activity
I533_RS17130	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I533_RS17135	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I533_RS17140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I533_RS17155	COG0281	malic enzyme
I533_RS17165	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I533_RS17195	COG0456	acetyltransferase
I533_RS17205	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I533_RS17210	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I533_RS17215	COG2177	Part of the ABC transporter FtsEX involved in
I533_RS17220	COG2884	Cell division ATP-binding protein ftsE
I533_RS17225	COG0552	protein localization to endoplasmic reticulum
I533_RS17230	COG0742	ribosomal rna small subunit methyltransferase
I533_RS17240	COG2095	MarC family integral membrane protein
I533_RS17260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I533_RS17265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I533_RS17270	COG0617	tRNA 3'-terminal CCA addition
I533_RS17275	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I533_RS17290	COG0076	glutamate decarboxylase activity
I533_RS17305	COG0842	Transport permease protein
I533_RS17310	COG1131	(ABC) transporter
I533_RS17315	COG0745	RESPONSE REGULATOR receiver
I533_RS17320	COG2205	protein histidine kinase activity
I533_RS17325	COG4774	siderophore transport
I533_RS17345	COG1253	flavin adenine dinucleotide binding
I533_RS17355	COG1966	Carbon starvation protein
I533_RS17365	COG0657	acetylesterase activity
I533_RS17380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I533_RS17385	COG0049	tRNA binding
I533_RS17390	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I533_RS17395	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I533_RS17400	COG0085	RNA polymerase activity
I533_RS17405	COG0222	ribosome binding
I533_RS17410	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I533_RS17415	COG0081	regulation of translation
I533_RS17420	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I533_RS17440	COG0250	Participates in transcription elongation, termination and antitermination
I533_RS17445	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I533_RS17455	COG1132	(ABC) transporter
I533_RS17460	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I533_RS17465	COG3590	peptidase
I533_RS17475	COG0513	Belongs to the DEAD box helicase family
I533_RS17480	COG0418	dihydroorotase activity
I533_RS17485	COG3040	lipid binding
I533_RS17490	COG4989	oxidoreductase activity
I533_RS17495	COG0346	lactoylglutathione lyase activity
I533_RS17500	COG0668	transmembrane transport
I533_RS17520	COG0302	gtp cyclohydrolase
I533_RS17530	COG2957	Belongs to the agmatine deiminase family
I533_RS17535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I533_RS17545	COG1201	RNA secondary structure unwinding
I533_RS17555	COG1793	dna ligase
I533_RS17560	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I533_RS17565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I533_RS17580	COG0625	glutathione transferase activity
I533_RS17585	COG0625	glutathione transferase activity
I533_RS17595	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I533_RS17610	COG1012	belongs to the aldehyde dehydrogenase family
I533_RS17615	COG0028	Belongs to the TPP enzyme family
I533_RS17625	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I533_RS17630	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I533_RS17635	COG0330	HflC and HflK could
I533_RS17640	COG0330	HflC and HflK could
I533_RS17645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I533_RS17650	COG1923	regulation of RNA biosynthetic process
I533_RS17655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I533_RS17670	COG0802	atpase or kinase
I533_RS17675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I533_RS17675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I533_RS17680	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I533_RS17700	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I533_RS17705	COG0735	belongs to the Fur family
I533_RS17725	COG0305	Participates in initiation and elongation during chromosome replication
I533_RS17750	COG2258	MOSC domain
I533_RS17780	COG2198	Histidine kinase
I533_RS17780	COG0784	Response regulator, receiver
I533_RS17780	COG2205	protein histidine kinase activity
I533_RS17790	COG1136	(ABC) transporter
I533_RS17800	COG0840	transmembrane signaling receptor activity
I533_RS17805	COG5002	protein histidine kinase activity
I533_RS17810	COG0840	transmembrane signaling receptor activity
I533_RS17835	COG1757	Na H antiporter
I533_RS17840	COG1472	Belongs to the glycosyl hydrolase 3 family
I533_RS17850	COG2723	6-phospho-beta-galactosidase activity
I533_RS17855	COG1609	Transcriptional regulator
I533_RS17860	COG2814	Major facilitator Superfamily
I533_RS17865	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I533_RS17870	COG4988	ABC transporter
I533_RS17880	COG1294	oxidase, subunit
I533_RS17920	COG4319	ketosteroid isomerase
I533_RS17940	COG2375	cellular response to nickel ion
I533_RS17945	COG3237	CsbD-like
I533_RS17975	COG0508	dehydrogenase complex catalyzes the overall conversion of
I533_RS17975	COG0596	Alpha beta hydrolase
I533_RS17995	COG3038	cytochrome b561
I533_RS18005	COG1252	NADH dehydrogenase
I533_RS18020	COG0583	DNA-binding transcription factor activity
I533_RS18025	COG2067	long-chain fatty acid transport protein
I533_RS18030	COG2130	NADP-dependent
I533_RS18035	COG2203	Gaf domain
I533_RS18035	COG3706	GGDEF domain
I533_RS18035	COG5001	Diguanylate cyclase
I533_RS18035	COG4251	negative regulation of phosphorylation
I533_RS18040	COG0784	Response regulator, receiver
I533_RS18040	COG2205	protein histidine kinase activity
I533_RS18050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I533_RS18110	COG0701	Predicted permease
I533_RS18155	COG0789	Transcriptional regulator
I533_RS18180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I533_RS18185	COG1349	DNA-binding transcription factor activity
I533_RS18190	COG0673	inositol 2-dehydrogenase activity
I533_RS18205	COG0697	spore germination
I533_RS18210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I533_RS18215	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I533_RS18220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I533_RS18225	COG1166	arginine decarboxylase activity
I533_RS18235	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I533_RS18290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I533_RS18300	COG0109	protoheme IX farnesyltransferase activity
I533_RS18320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I533_RS18335	COG1487	ribonuclease activity
I533_RS18365	COG3030	protein affecting phage T7 exclusion by the F plasmid
I533_RS18370	COG1324	tolerance protein
I533_RS18375	COG4232	protein-disulfide reductase activity
I533_RS18380	COG0739	heme binding
I533_RS18385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I533_RS18390	COG0511	ligase activity, forming carbon-carbon bonds
I533_RS18395	COG0439	Biotin carboxylase
I533_RS18440	COG0154	amidase activity
I533_RS18455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I533_RS18460	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I533_RS18475	COG0151	Belongs to the GarS family
I533_RS18490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I533_RS18495	COG3954	Phosphoribulokinase
I533_RS18520	COG1501	Belongs to the glycosyl hydrolase 31 family
I533_RS18525	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I533_RS18535	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I533_RS18545	COG3031	protein transport across the cell outer membrane
I533_RS18555	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I533_RS18560	COG1459	type II secretion system
I533_RS18565	COG2165	general secretion pathway protein
I533_RS18570	COG2165	general secretion pathway protein
I533_RS18575	COG2165	general secretion pathway protein
I533_RS18580	COG4795	General secretion pathway protein
I533_RS18595	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I533_RS18610	COG1012	belongs to the aldehyde dehydrogenase family
I533_RS18620	COG1011	Hydrolase
I533_RS18625	COG0494	nUDIX hydrolase
I533_RS18630	COG1218	3'(2'),5'-bisphosphate nucleotidase
I533_RS18640	COG2943	transferase activity, transferring hexosyl groups
I533_RS18645	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I533_RS18655	COG3089	Belongs to the UPF0270 family
I533_RS18660	COG0429	hydrolase of the alpha beta-hydrolase fold
I533_RS18670	COG0488	(ABC) transporter
I533_RS18685	COG2900	Belongs to the SlyX family
I533_RS18695	COG0545	Peptidyl-prolyl cis-trans isomerase
I533_RS18705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I533_RS18710	COG2183	response to ionizing radiation
I533_RS18730	COG0596	Alpha beta hydrolase
I533_RS18735	COG1040	competence protein
I533_RS18755	COG1794	racemase activity, acting on amino acids and derivatives
I533_RS18765	COG0534	Mate efflux family protein
I533_RS18770	COG0726	polysaccharide deacetylase
I533_RS18770	COG1649	PFAM Uncharacterised BCR, COG1649
I533_RS18780	COG1999	signal sequence binding
I533_RS18785	COG0109	protoheme IX farnesyltransferase activity
I533_RS18790	COG1612	heme a metabolic process
I533_RS18810	COG1845	cytochrome c oxidase, subunit III
I533_RS18815	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I533_RS18820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I533_RS18825	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I533_RS18845	COG0129	dihydroxy-acid dehydratase activity
I533_RS18855	COG0606	chelatase, subunit chli
I533_RS18870	COG2814	Major facilitator Superfamily
I533_RS18880	COG0729	surface antigen
I533_RS18885	COG2911	Protein conserved in bacteria
I533_RS18910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I533_RS18920	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I533_RS18940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I533_RS18965	COG1228	amidohydrolase
I533_RS18990	COG0425	Belongs to the sulfur carrier protein TusA family
I533_RS19005	COG1561	YicC-like family, N-terminal region
I533_RS19015	COG3550	peptidyl-serine autophosphorylation
I533_RS19020	COG3620	sequence-specific DNA binding
I533_RS19045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I533_RS19070	COG4771	TonB-dependent receptor
I533_RS19080	COG3119	arylsulfatase activity
I533_RS19085	COG0714	Associated with various cellular activities
I533_RS19100	COG2304	oxidoreductase activity
I533_RS19130	COG0318	PFAM AMP-dependent synthetase and ligase
I533_RS19135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I533_RS19145	COG1960	acyl-CoA dehydrogenase activity
I533_RS19155	COG1024	Enoyl-CoA hydratase
I533_RS19185	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I533_RS19205	COG0129	dihydroxy-acid dehydratase activity
I533_RS19215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I533_RS19220	COG1737	Transcriptional regulator
I533_RS19225	COG0469	pyruvate kinase activity
I533_RS19230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I533_RS19265	COG3177	Filamentation induced by cAMP protein fic
I533_RS19280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I533_RS19295	COG0706	membrane insertase activity
I533_RS19300	COG0594	ribonuclease P activity
I533_RS19305	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I533_RS19330	COG2327	Polysaccharide pyruvyl transferase
I533_RS19380	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I533_RS19390	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I533_RS19410	COG1216	Glycosyl transferase, family 2
I533_RS19410	COG0438	transferase activity, transferring glycosyl groups
I533_RS19425	COG4771	TonB-dependent receptor
I533_RS19430	COG2184	nucleotidyltransferase activity
I533_RS19550	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I533_RS19585	COG0789	Transcriptional regulator
I533_RS19620	COG5507	3-demethylubiquinone-9 3-methyltransferase
I533_RS19640	COG4890	Cyd operon protein YbgT
I533_RS19660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I533_RS19675	COG1469	GTP cyclohydrolase I activity