locus-tag	class	description
I876_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I876_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I876_RS00040	COG2818	Glycosylase
I876_RS00050	COG3078	GTPase activator activity
I876_RS00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I876_RS00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I876_RS00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I876_RS00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I876_RS00085	COG0569	domain protein
I876_RS00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I876_RS00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I876_RS00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I876_RS00110	COG0758	DNA mediated transformation
I876_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
I876_RS00130	COG0408	coproporphyrinogen oxidase activity
I876_RS00135	COG3047	cAMP biosynthetic process
I876_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I876_RS00235	COG2234	aminopeptidase activity
I876_RS00240	COG0463	Glycosyl transferase, family 2
I876_RS00250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I876_RS00275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I876_RS00305	COG3642	lipopolysaccharide core region biosynthetic process
I876_RS00310	COG0859	PFAM glycosyl transferase family 9
I876_RS00340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I876_RS00355	COG3161	chorismate lyase activity
I876_RS00360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I876_RS00380	COG0210	DNA helicase
I876_RS00410	COG1757	Na H antiporter
I876_RS00425	COG1959	2 iron, 2 sulfur cluster binding
I876_RS00430	COG0730	response to heat
I876_RS00445	COG4771	TonB-dependent receptor
I876_RS00460	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I876_RS00465	COG4988	ABC transporter
I876_RS00475	COG1271	oxidase subunit
I876_RS00485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I876_RS00485	COG0425	Belongs to the sulfur carrier protein TusA family
I876_RS00495	COG0450	alkyl hydroperoxide reductase
I876_RS00505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I876_RS00535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I876_RS00565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I876_RS00570	COG0842	Transport permease protein
I876_RS00570	COG1129	ABC transporter
I876_RS00575	COG0842	Transport permease protein
I876_RS00590	COG1960	acyl-CoA dehydrogenase activity
I876_RS00595	COG0583	DNA-binding transcription factor activity
I876_RS00605	COG3106	COG3106 Predicted ATPase
I876_RS00620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I876_RS00640	COG0352	thiamine-phosphate diphosphorylase activity
I876_RS00650	COG3071	HemY protein
I876_RS00655	COG2959	enzyme of heme biosynthesis
I876_RS00665	COG0181	hydroxymethylbilane synthase activity
I876_RS00680	COG0194	GDP metabolic process
I876_RS00690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I876_RS00700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I876_RS00705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I876_RS00715	COG0678	peroxiredoxin activity
I876_RS00730	COG1178	ABC-type Fe3 transport system permease component
I876_RS00735	COG3842	ATPase activity
I876_RS00740	COG0668	transmembrane transport
I876_RS00745	COG2081	HI0933 family
I876_RS00755	COG2963	transposase activity
I876_RS00775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I876_RS00790	COG0427	acetyl-CoA hydrolase
I876_RS00795	COG0123	including yeast histone deacetylase and acetoin utilization protein
I876_RS00810	COG0840	transmembrane signaling receptor activity
I876_RS00820	COG3064	Membrane
I876_RS00830	COG5001	Diguanylate cyclase
I876_RS00830	COG5002	protein histidine kinase activity
I876_RS00845	COG0514	ATP-dependent DNA helicase (RecQ)
I876_RS00850	COG2239	Acts as a magnesium transporter
I876_RS00855	COG2962	Rard protein
I876_RS00865	COG0210	DNA helicase
I876_RS00875	COG1011	Hydrolase
I876_RS00880	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I876_RS00890	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I876_RS00895	COG0019	diaminopimelate decarboxylase activity
I876_RS00940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I876_RS00940	COG2755	lipolytic protein G-D-S-L family
I876_RS00955	COG0163	prenyltransferase activity
I876_RS00960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I876_RS00970	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I876_RS00990	COG1077	Cell shape determining protein MreB Mrl
I876_RS01000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I876_RS01015	COG1085	galactose-1-phosphate uridylyltransferase
I876_RS01020	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I876_RS01030	COG0629	single-stranded DNA binding
I876_RS01045	COG3250	beta-galactosidase activity
I876_RS01065	COG1349	DNA-binding transcription factor activity
I876_RS01110	COG3267	Type II secretory pathway component ExeA
I876_RS01110	COG3409	Peptidoglycan-binding domain 1 protein
I876_RS01120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I876_RS01125	COG1459	type II secretion system
I876_RS01135	COG2165	general secretion pathway protein
I876_RS01140	COG2165	general secretion pathway protein
I876_RS01170	COG1077	Cell shape determining protein MreB Mrl
I876_RS01175	COG1792	Involved in formation and maintenance of cell shape
I876_RS01180	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I876_RS01190	COG1530	ribonuclease E activity
I876_RS01200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I876_RS01205	COG0312	modulator of DNA gyrase
I876_RS01210	COG3028	Belongs to the UPF0307 family
I876_RS01215	COG0312	modulator of DNA gyrase
I876_RS01230	COG0745	RESPONSE REGULATOR receiver
I876_RS01235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I876_RS01235	COG4191	Histidine kinase
I876_RS01240	COG0297	glycogen (starch) synthase activity
I876_RS01250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I876_RS01255	COG0596	Alpha beta hydrolase
I876_RS01275	COG2865	translation initiation factor activity
I876_RS01350	COG5310	Homospermidine synthase
I876_RS01375	COG3251	PFAM MbtH domain protein
I876_RS01525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I876_RS01535	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I876_RS01545	COG0463	Glycosyl transferase, family 2
I876_RS01550	COG0745	RESPONSE REGULATOR receiver
I876_RS01555	COG5002	protein histidine kinase activity
I876_RS01610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I876_RS01615	COG5002	protein histidine kinase activity
I876_RS01620	COG0745	RESPONSE REGULATOR receiver
I876_RS01640	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I876_RS01705	COG1017	nitric oxide dioxygenase activity
I876_RS01705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I876_RS01725	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I876_RS01755	COG0375	protein maturation
I876_RS01765	COG0409	Hydrogenase expression formation protein
I876_RS01775	COG0309	Hydrogenase expression formation protein (HypE)
I876_RS01780	COG0789	Transcriptional regulator
I876_RS01785	COG2217	Heavy metal translocating P-type atpase
I876_RS01855	COG0531	amino acid
I876_RS01865	COG2132	Multicopper oxidase
I876_RS01895	COG0745	RESPONSE REGULATOR receiver
I876_RS01905	COG0835	chemotaxis
I876_RS01920	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I876_RS01935	COG0745	RESPONSE REGULATOR receiver
I876_RS01945	COG0835	chemotaxis
I876_RS01965	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I876_RS01995	COG0546	phosphoglycolate phosphatase activity
I876_RS02015	COG1609	Transcriptional regulator
I876_RS02020	COG0673	inositol 2-dehydrogenase activity
I876_RS02030	COG2211	Major facilitator Superfamily
I876_RS02055	COG1454	alcohol dehydrogenase
I876_RS02100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I876_RS02120	COG0089	rRNA binding
I876_RS02130	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I876_RS02140	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I876_RS02155	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I876_RS02160	COG0438	transferase activity, transferring glycosyl groups
I876_RS02170	COG1519	Transferase
I876_RS02190	COG0840	transmembrane signaling receptor activity
I876_RS02205	COG0788	formyltetrahydrofolate deformylase activity
I876_RS02215	COG1643	Atp-dependent helicase
I876_RS02220	COG2951	lytic endotransglycosylase activity
I876_RS02225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I876_RS02235	COG2354	Protein conserved in bacteria
I876_RS02255	COG0004	ammonium transporteR
I876_RS02260	COG0405	Gamma-glutamyltransferase
I876_RS02265	COG2837	iron assimilation
I876_RS02280	COG0540	Belongs to the ATCase OTCase family
I876_RS02305	COG5002	protein histidine kinase activity
I876_RS02305	COG2205	protein histidine kinase activity
I876_RS02305	COG0784	Response regulator, receiver
I876_RS02330	COG1012	belongs to the aldehyde dehydrogenase family
I876_RS02340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I876_RS02355	COG0180	Tryptophanyl-tRNA synthetase
I876_RS02360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I876_RS02380	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I876_RS02390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I876_RS02425	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I876_RS02430	COG0281	malic enzyme
I876_RS02440	COG0625	glutathione transferase activity
I876_RS02450	COG0753	catalase activity
I876_RS02465	COG3300	MHYT domain
I876_RS02465	COG5001	Diguanylate cyclase
I876_RS02470	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I876_RS02470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I876_RS02480	COG0137	argininosuccinate synthase activity
I876_RS02500	COG1803	Methylglyoxal synthase
I876_RS02510	COG0745	RESPONSE REGULATOR receiver
I876_RS02515	COG2205	protein histidine kinase activity
I876_RS02520	COG2267	carboxylic ester hydrolase activity
I876_RS02525	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I876_RS02535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I876_RS02545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I876_RS02550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I876_RS02555	COG4942	peptidase
I876_RS02560	COG2861	carbohydrate metabolic process
I876_RS02585	COG1162	GTPase activity
I876_RS02590	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I876_RS02620	COG0028	Belongs to the TPP enzyme family
I876_RS02640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I876_RS02645	COG0805	protein transport
I876_RS02655	COG0084	hydrolase, TatD family'
I876_RS02660	COG2203	Gaf domain
I876_RS02660	COG5001	Diguanylate cyclase
I876_RS02660	COG4251	negative regulation of phosphorylation
I876_RS02660	COG3706	GGDEF domain
I876_RS02670	COG0248	Ppx GppA phosphatase
I876_RS02675	COG0513	Belongs to the DEAD box helicase family
I876_RS02680	COG3118	belongs to the thioredoxin family
I876_RS02685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I876_RS02690	COG1473	amidohydrolase
I876_RS02695	COG5002	protein histidine kinase activity
I876_RS02695	COG0784	Response regulator, receiver
I876_RS02700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I876_RS02705	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I876_RS02710	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I876_RS02725	COG0783	Belongs to the Dps family
I876_RS02730	COG2133	pyrroloquinoline quinone binding
I876_RS02735	COG0823	Involved in the tonB-independent uptake of proteins
I876_RS02735	COG1506	peptidase
I876_RS02735	COG4946	Tricorn protease homolog
I876_RS02745	COG3118	belongs to the thioredoxin family
I876_RS02760	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I876_RS02770	COG1012	belongs to the aldehyde dehydrogenase family
I876_RS02790	COG1757	Na H antiporter
I876_RS02805	COG3876	Protein conserved in bacteria
I876_RS02810	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I876_RS02820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I876_RS02830	COG0346	lactoylglutathione lyase activity
I876_RS02855	COG2824	Alkylphosphonate utilization operon protein PhnA
I876_RS02860	COG0454	-acetyltransferase
I876_RS02885	COG3093	addiction module antidote protein HigA
I876_RS02900	COG2026	Addiction module toxin, RelE StbE family
I876_RS02950	COG1733	regulation of RNA biosynthetic process
I876_RS02970	COG0183	Belongs to the thiolase family
I876_RS02975	COG1250	3-hydroxyacyl-CoA dehydrogenase
I876_RS02975	COG1024	Enoyl-CoA hydratase
I876_RS02985	COG0006	proline dipeptidase activity
I876_RS02995	COG0142	geranyltranstransferase activity
I876_RS03025	COG1388	LysM domain
I876_RS03025	COG4942	peptidase
I876_RS03030	COG1238	metal cluster binding
I876_RS03040	COG0585	pseudouridine synthase activity
I876_RS03045	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I876_RS03055	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I876_RS03065	COG0840	transmembrane signaling receptor activity
I876_RS03095	COG0494	nUDIX hydrolase
I876_RS03105	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I876_RS03110	COG0730	response to heat
I876_RS03115	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I876_RS03120	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I876_RS03155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I876_RS03165	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I876_RS03175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I876_RS03175	COG1648	precorrin-2 dehydrogenase activity
I876_RS03180	COG0513	Belongs to the DEAD box helicase family
I876_RS03195	COG1538	Outer membrane efflux protein
I876_RS03200	COG0494	nUDIX hydrolase
I876_RS03210	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I876_RS03215	COG3150	esterase
I876_RS03220	COG0187	DNA topoisomerase II activity
I876_RS03230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I876_RS03255	COG1509	lysine 2,3-aminomutase activity
I876_RS03260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I876_RS03265	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I876_RS03280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I876_RS03295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I876_RS03310	COG0271	Belongs to the BolA IbaG family
I876_RS03325	COG3707	response regulator
I876_RS03340	COG0659	secondary active sulfate transmembrane transporter activity
I876_RS03345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I876_RS03355	COG0243	molybdopterin cofactor binding
I876_RS03360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I876_RS03360	COG1648	precorrin-2 dehydrogenase activity
I876_RS03365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I876_RS03375	COG1116	anion transmembrane transporter activity
I876_RS03375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I876_RS03385	COG1116	anion transmembrane transporter activity
I876_RS03400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I876_RS03405	COG4206	TonB-dependent receptor
I876_RS03415	COG0348	domain, Protein
I876_RS03430	COG1960	acyl-CoA dehydrogenase activity
I876_RS03435	COG1028	Short-chain dehydrogenase reductase Sdr
I876_RS03445	COG4948	Mandelate Racemase Muconate Lactonizing
I876_RS03460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I876_RS03465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I876_RS03490	COG0358	DNA primase activity
I876_RS03515	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I876_RS03520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I876_RS03535	COG0537	adenosine 5'-monophosphoramidase activity
I876_RS03550	COG3135	benzoate transporter
I876_RS03555	COG1396	sequence-specific DNA binding
I876_RS03560	COG2974	May be involved in recombination
I876_RS03565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I876_RS03565	COG4191	Histidine kinase
I876_RS03570	COG0745	RESPONSE REGULATOR receiver
I876_RS03575	COG5002	protein histidine kinase activity
I876_RS03600	COG0811	peptide transport
I876_RS03605	COG0811	peptide transport
I876_RS03610	COG0848	biopolymer transport protein
I876_RS03615	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I876_RS03625	COG3437	response regulator, receiver
I876_RS03645	COG2133	pyrroloquinoline quinone binding
I876_RS03650	COG1049	propionate catabolic process, 2-methylcitrate cycle
I876_RS03665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I876_RS03690	COG0527	aspartate kinase activity
I876_RS03700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I876_RS03705	COG2967	ApaG domain
I876_RS03715	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I876_RS03720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I876_RS03725	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I876_RS03730	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I876_RS03740	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I876_RS03760	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I876_RS03775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I876_RS03780	COG3956	TIGRFAM MazG family protein
I876_RS03805	COG1028	Short-chain dehydrogenase reductase Sdr
I876_RS03815	COG0318	PFAM AMP-dependent synthetase and ligase
I876_RS03825	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I876_RS03835	COG0463	Glycosyl transferase, family 2
I876_RS03855	COG0642	Histidine kinase
I876_RS03875	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I876_RS03880	COG0723	plastoquinol--plastocyanin reductase activity
I876_RS03885	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I876_RS03890	COG2857	Cytochrome c1
I876_RS03895	COG0625	glutathione transferase activity
I876_RS03900	COG2969	positive regulation of protein catabolic process
I876_RS03905	COG2239	Acts as a magnesium transporter
I876_RS03910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I876_RS03930	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I876_RS03935	COG1137	ATPase activity
I876_RS03940	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I876_RS03950	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I876_RS03965	COG1127	ABC transporter
I876_RS03970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I876_RS03975	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I876_RS03980	COG2854	intermembrane phospholipid transfer
I876_RS03990	COG5007	Belongs to the BolA IbaG family
I876_RS04000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I876_RS04005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I876_RS04015	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I876_RS04040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I876_RS04050	COG4771	TonB-dependent receptor
I876_RS04055	COG0697	spore germination
I876_RS04065	COG2205	protein histidine kinase activity
I876_RS04065	COG0784	Response regulator, receiver
I876_RS04090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I876_RS04100	COG0126	phosphoglycerate kinase activity
I876_RS04105	COG3588	fructose-bisphosphate aldolase
I876_RS04115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I876_RS04125	COG1538	Outer membrane efflux protein
I876_RS04130	COG4946	Tricorn protease homolog
I876_RS04130	COG1506	peptidase
I876_RS04130	COG0823	Involved in the tonB-independent uptake of proteins
I876_RS04135	COG0248	Ppx GppA phosphatase
I876_RS04140	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I876_RS04150	COG0573	inorganic phosphate transmembrane transporter activity
I876_RS04160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I876_RS04170	COG0306	phosphate transporter
I876_RS04180	COG0583	DNA-binding transcription factor activity
I876_RS04190	COG1272	protein, Hemolysin III
I876_RS04195	COG1846	Transcriptional regulator
I876_RS04200	COG1764	response to oxidative stress
I876_RS04215	COG1739	Uncharacterized protein family UPF0029
I876_RS04225	COG0420	3'-5' exonuclease activity
I876_RS04230	COG0419	ATPase involved in DNA repair
I876_RS04240	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I876_RS04255	COG2188	Transcriptional regulator
I876_RS04265	COG2986	histidine ammonia-lyase
I876_RS04290	COG0488	(ABC) transporter
I876_RS04310	COG0668	transmembrane transport
I876_RS04365	COG1346	cytolysis
I876_RS04395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I876_RS04405	COG0513	Belongs to the DEAD box helicase family
I876_RS04415	COG3267	Type II secretory pathway component ExeA
I876_RS04415	COG3409	Peptidoglycan-binding domain 1 protein
I876_RS04430	COG0066	3-isopropylmalate dehydratase activity
I876_RS04440	COG0473	3-isopropylmalate dehydrogenase activity
I876_RS04445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I876_RS04465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I876_RS04480	COG4555	ABC transporter
I876_RS04485	COG1668	transmembrane transport
I876_RS04500	COG4133	protoheme IX ABC transporter activity
I876_RS04505	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I876_RS04510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I876_RS04515	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I876_RS04525	COG1138	Cytochrome C-type biogenesis protein
I876_RS04530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I876_RS04545	COG2853	Lipoprotein
I876_RS04550	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I876_RS04590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I876_RS04605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I876_RS04610	COG1596	polysaccharide export
I876_RS04610	COG1555	photosystem II stabilization
I876_RS04615	COG0473	3-isopropylmalate dehydrogenase activity
I876_RS04630	COG1611	Belongs to the LOG family
I876_RS04640	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I876_RS04640	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I876_RS04695	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I876_RS04700	COG0024	Methionine aminopeptidase
I876_RS04705	COG0052	Belongs to the universal ribosomal protein uS2 family
I876_RS04715	COG0528	UMP kinase activity
I876_RS04730	COG0575	Belongs to the CDS family
I876_RS04755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I876_RS04775	COG0587	DNA-directed DNA polymerase activity
I876_RS04780	COG0825	malonyl-CoA metabolic process
I876_RS04785	COG0037	tRNA processing
I876_RS04815	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I876_RS04815	COG0047	phosphoribosylformylglycinamidine synthase activity
I876_RS04820	COG2840	Smr protein MutS2
I876_RS04920	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I876_RS04950	COG3314	Sporulation integral membrane protein YlbJ
I876_RS04960	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I876_RS04965	COG2188	Transcriptional regulator
I876_RS04970	COG1228	amidohydrolase
I876_RS04975	COG0402	S-adenosylhomocysteine deaminase activity
I876_RS05000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I876_RS05005	COG2197	response regulator
I876_RS05040	COG0835	chemotaxis
I876_RS05040	COG0784	Response regulator, receiver
I876_RS05045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I876_RS05050	COG1815	bacterial-type flagellum-dependent cell motility
I876_RS05065	COG1749	Flagellar hook protein flgE
I876_RS05070	COG4787	bacterial-type flagellum-dependent cell motility
I876_RS05090	COG1705	Flagellar rod assembly protein muramidase FlgJ
I876_RS05090	COG3951	Flagellar rod assembly protein muramidase FlgJ
I876_RS05095	COG1256	bacterial-type flagellum assembly
I876_RS05125	COG1334	flagellar protein FlaG
I876_RS05130	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I876_RS05160	COG2089	acid synthase
I876_RS05165	COG3980	spore coat polysaccharide biosynthesis protein
I876_RS05170	COG1083	cytidylyl-transferase
I876_RS05175	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I876_RS05180	COG1086	Polysaccharide biosynthesis protein
I876_RS05205	COG1677	Flagellar hook-basal body complex protein FliE
I876_RS05210	COG1766	The M ring may be actively involved in energy transduction
I876_RS05215	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I876_RS05265	COG1987	bacterial-type flagellum assembly
I876_RS05280	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I876_RS05305	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I876_RS05310	COG2198	Histidine kinase
I876_RS05310	COG0784	Response regulator, receiver
I876_RS05310	COG0643	Histidine kinase
I876_RS05320	COG1192	Involved in chromosome partitioning
I876_RS05330	COG0835	chemotaxis
I876_RS05345	COG1410	methionine synthase
I876_RS05345	COG0646	methionine synthase
I876_RS05350	COG1410	methionine synthase
I876_RS05350	COG0646	methionine synthase
I876_RS05360	COG3123	guanosine phosphorylase activity
I876_RS05365	COG0583	DNA-binding transcription factor activity
I876_RS05370	COG0583	DNA-binding transcription factor activity
I876_RS05380	COG0659	secondary active sulfate transmembrane transporter activity
I876_RS05395	COG3590	peptidase
I876_RS05405	COG2137	regulation of response to DNA damage stimulus
I876_RS05410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I876_RS05440	COG5016	pyruvate
I876_RS05440	COG0511	ligase activity, forming carbon-carbon bonds
I876_RS05445	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I876_RS05450	COG4172	Belongs to the ABC transporter superfamily
I876_RS05460	COG4171	peptide transport system, permease
I876_RS05465	COG4168	peptide transport system, permease
I876_RS05470	COG0747	negative chemotaxis
I876_RS05475	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I876_RS05480	COG1842	Phage shock protein A
I876_RS05510	COG0625	glutathione transferase activity
I876_RS05515	COG1522	sequence-specific DNA binding
I876_RS05580	COG0811	peptide transport
I876_RS05585	COG0811	peptide transport
I876_RS05590	COG0848	biopolymer transport protein
I876_RS05605	COG1444	tRNA N-acetyltransferase activity
I876_RS05645	COG0456	acetyltransferase
I876_RS05655	COG0583	DNA-binding transcription factor activity
I876_RS05660	COG2814	Major facilitator Superfamily
I876_RS05670	COG0656	L-ascorbic acid biosynthetic process
I876_RS05685	COG1846	Transcriptional regulator
I876_RS05725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I876_RS05760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I876_RS05760	COG0543	2 iron, 2 sulfur cluster binding
I876_RS05775	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I876_RS05780	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I876_RS05785	COG0564	pseudouridine synthase activity
I876_RS05795	COG0612	Peptidase, M16
I876_RS05800	COG2918	glutathione biosynthetic process
I876_RS05820	COG2840	Smr protein MutS2
I876_RS05825	COG2890	protein-(glutamine-N5) methyltransferase activity
I876_RS05840	COG2719	SpoVR family
I876_RS05845	COG2718	Belongs to the UPF0229 family
I876_RS05850	COG2766	serine protein kinase
I876_RS05855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I876_RS05860	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I876_RS05865	COG4771	TonB-dependent receptor
I876_RS05890	COG0450	alkyl hydroperoxide reductase
I876_RS05900	COG2885	chlorophyll binding
I876_RS05905	COG0584	glycerophosphoryl diester phosphodiesterase
I876_RS05910	COG0346	lactoylglutathione lyase activity
I876_RS05915	COG1278	Cold shock
I876_RS05930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I876_RS05935	COG4660	Part of a membrane complex involved in electron transport
I876_RS05940	COG4659	FMN binding
I876_RS05945	COG4658	electron transport chain
I876_RS05950	COG4656	Part of a membrane complex involved in electron transport
I876_RS05955	COG2878	Part of a membrane complex involved in electron transport
I876_RS05960	COG4657	Part of a membrane complex involved in electron transport
I876_RS05975	COG0534	Mate efflux family protein
I876_RS05980	COG0556	nucleotide-excision repair
I876_RS05995	COG0602	queuosine metabolic process
I876_RS06005	COG0367	asparagine synthase
I876_RS06030	COG0471	metal ion transport
I876_RS06030	COG3273	potassium ion transport
I876_RS06045	COG0529	Catalyzes the synthesis of activated sulfate
I876_RS06050	COG0175	sulfate reduction
I876_RS06055	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I876_RS06060	COG3706	GGDEF domain
I876_RS06085	COG2304	oxidoreductase activity
I876_RS06105	COG0714	Associated with various cellular activities
I876_RS06115	COG1024	Enoyl-CoA hydratase
I876_RS06115	COG1250	3-hydroxyacyl-CoA dehydrogenase
I876_RS06130	COG1025	Belongs to the peptidase M16 family
I876_RS06135	COG2062	phosphohistidine phosphatase, SixA
I876_RS06145	COG4536	flavin adenine dinucleotide binding
I876_RS06150	COG4137	Cytochrome C assembly protein
I876_RS06155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I876_RS06205	COG1132	(ABC) transporter
I876_RS06220	COG0228	four-way junction DNA binding
I876_RS06225	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I876_RS06230	COG0336	Belongs to the RNA methyltransferase TrmD family
I876_RS06235	COG0335	large ribosomal subunit rRNA binding
I876_RS06240	COG2860	membrane
I876_RS06250	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I876_RS06255	COG0287	Prephenate dehydrogenase
I876_RS06255	COG1605	Chorismate mutase
I876_RS06260	COG0077	Prephenate dehydratase
I876_RS06260	COG1605	Chorismate mutase
I876_RS06265	COG0745	RESPONSE REGULATOR receiver
I876_RS06270	COG0023	Translation Initiation Factor
I876_RS06300	COG2205	protein histidine kinase activity
I876_RS06310	COG2204	response regulator
I876_RS06330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I876_RS06335	COG0494	nUDIX hydrolase
I876_RS06340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I876_RS06345	COG0632	four-way junction helicase activity
I876_RS06350	COG2255	four-way junction helicase activity
I876_RS06355	COG0824	Thioesterase
I876_RS06360	COG0811	peptide transport
I876_RS06375	COG0823	Involved in the tonB-independent uptake of proteins
I876_RS06380	COG2885	chlorophyll binding
I876_RS06385	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I876_RS06400	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I876_RS06415	COG4667	esterase of the alpha-beta hydrolase superfamily
I876_RS06420	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I876_RS06435	COG1028	Short-chain dehydrogenase reductase Sdr
I876_RS06440	COG3038	cytochrome b561
I876_RS06465	COG1451	nucleotide metabolic process
I876_RS06475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I876_RS06485	COG1309	transcriptional regulator
I876_RS06490	COG4774	siderophore transport
I876_RS06510	COG3706	GGDEF domain
I876_RS06520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I876_RS06520	COG3008	intermembrane lipid transfer
I876_RS06525	COG2995	paraquat-inducible protein a
I876_RS06540	COG0017	Asparaginyl-tRNA synthetase
I876_RS06555	COG0189	ligase activity
I876_RS06585	COG0156	8-amino-7-oxononanoate synthase activity
I876_RS06590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I876_RS06600	COG3340	Belongs to the peptidase S51 family
I876_RS06605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I876_RS06610	COG4139	cobalamin transport
I876_RS06615	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I876_RS06620	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I876_RS06635	COG5265	(ABC) transporter
I876_RS06640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I876_RS06650	COG0745	RESPONSE REGULATOR receiver
I876_RS06670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I876_RS06715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I876_RS06730	COG2755	lipolytic protein G-D-S-L family
I876_RS06735	COG4181	ATPase activity
I876_RS06740	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I876_RS06745	COG1090	epimerase
I876_RS06750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I876_RS06755	COG0628	permease
I876_RS06780	COG2350	Protein conserved in bacteria
I876_RS06785	COG0159	tryptophan synthase activity
I876_RS06795	COG0134	indole-3-glycerol-phosphate synthase activity
I876_RS06795	COG0135	phosphoribosylanthranilate isomerase activity
I876_RS06800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I876_RS06810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I876_RS06815	COG0613	PHP domain protein
I876_RS06820	COG0009	L-threonylcarbamoyladenylate synthase
I876_RS06830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I876_RS06840	COG0656	L-ascorbic acid biosynthetic process
I876_RS06845	COG0110	maltose O-acetyltransferase activity
I876_RS06855	COG2733	membrane
I876_RS06860	COG0500	methyltransferase
I876_RS06865	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I876_RS06870	COG0497	DNA recombination
I876_RS06875	COG0783	Belongs to the Dps family
I876_RS06880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I876_RS06885	COG1454	alcohol dehydrogenase
I876_RS06890	COG1028	Short-chain dehydrogenase reductase Sdr
I876_RS06900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I876_RS06905	COG2610	gluconate transmembrane transporter activity
I876_RS06920	COG2205	protein histidine kinase activity
I876_RS06920	COG0784	Response regulator, receiver
I876_RS06920	COG2198	Histidine kinase
I876_RS06925	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I876_RS06935	COG0484	heat shock protein binding
I876_RS06940	COG3909	cytochrome
I876_RS06945	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I876_RS06960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I876_RS06970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I876_RS06975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I876_RS07000	COG0857	belongs to the CobB CobQ family
I876_RS07000	COG0280	phosphate acetyltransferase
I876_RS07015	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I876_RS07020	COG4535	Mg2 and Co2 transporter CorC
I876_RS07030	COG1702	phosphate starvation-inducible protein PhoH
I876_RS07040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I876_RS07065	COG1607	acyl-coa hydrolase
I876_RS07070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I876_RS07080	COG1115	amino acid carrier protein
I876_RS07135	COG0012	GTP binding
I876_RS07150	COG1064	alcohol dehydrogenase
I876_RS07165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I876_RS07175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I876_RS07180	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I876_RS07185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I876_RS07195	COG2890	protein-(glutamine-N5) methyltransferase activity
I876_RS07200	COG3437	response regulator, receiver
I876_RS07200	COG0784	Response regulator, receiver
I876_RS07210	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I876_RS07220	COG0583	DNA-binding transcription factor activity
I876_RS07230	COG2363	Small membrane protein
I876_RS07245	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I876_RS07250	COG0515	serine threonine protein kinase
I876_RS07255	COG2116	formate transmembrane transporter activity
I876_RS07270	COG0714	Associated with various cellular activities
I876_RS07275	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I876_RS07280	COG0033	Phosphoglucomutase
I876_RS07285	COG0058	SHG alpha-glucan phosphorylase activity
I876_RS07295	COG2988	succinylglutamate desuccinylase activity
I876_RS07330	COG1393	Belongs to the ArsC family
I876_RS07355	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I876_RS07415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I876_RS07415	COG0475	glutathione-regulated potassium exporter activity
I876_RS07430	COG1733	regulation of RNA biosynthetic process
I876_RS07435	COG5001	Diguanylate cyclase
I876_RS07435	COG3447	MASE1 domain protein
I876_RS07435	COG5002	protein histidine kinase activity
I876_RS07445	COG0402	S-adenosylhomocysteine deaminase activity
I876_RS07450	COG2351	hydroxyisourate hydrolase activity
I876_RS07465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I876_RS07480	COG1309	transcriptional regulator
I876_RS07495	COG2252	PERMEase
I876_RS07500	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I876_RS07515	COG2203	Gaf domain
I876_RS07515	COG3706	GGDEF domain
I876_RS07515	COG5001	Diguanylate cyclase
I876_RS07515	COG4251	negative regulation of phosphorylation
I876_RS07520	COG3706	GGDEF domain
I876_RS07520	COG4251	negative regulation of phosphorylation
I876_RS07520	COG5001	Diguanylate cyclase
I876_RS07520	COG2203	Gaf domain
I876_RS07525	COG2205	protein histidine kinase activity
I876_RS07525	COG0784	Response regulator, receiver
I876_RS07540	COG2233	PERMEase
I876_RS07555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I876_RS07560	COG0730	response to heat
I876_RS07600	COG1028	Short-chain dehydrogenase reductase Sdr
I876_RS07605	COG3001	Fructosamine kinase
I876_RS07615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I876_RS07645	COG1596	polysaccharide export
I876_RS07650	COG0489	protein tyrosine kinase activity
I876_RS07655	COG4464	protein tyrosine phosphatase activity
I876_RS07680	COG3300	MHYT domain
I876_RS07680	COG5001	Diguanylate cyclase
I876_RS07690	COG0297	glycogen (starch) synthase activity
I876_RS07705	COG1215	transferase activity, transferring glycosyl groups
I876_RS07710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I876_RS07715	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I876_RS07745	COG0297	glycogen (starch) synthase activity
I876_RS07760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I876_RS07760	COG0072	phenylalanine-tRNA ligase activity
I876_RS07775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I876_RS07785	COG1472	Belongs to the glycosyl hydrolase 3 family
I876_RS07790	COG2096	Adenosyltransferase
I876_RS07800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I876_RS07810	COG4591	ABC-type transport system involved in lipoprotein release permease component
I876_RS07835	COG0708	Exodeoxyribonuclease III
I876_RS07870	COG2814	Major facilitator Superfamily
I876_RS07905	COG4770	biotin carboxylase activity
I876_RS07910	COG1024	Enoyl-CoA hydratase
I876_RS07915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I876_RS07920	COG1960	acyl-CoA dehydrogenase activity
I876_RS07925	COG0789	Transcriptional regulator
I876_RS07930	COG0183	Belongs to the thiolase family
I876_RS07945	COG3706	GGDEF domain
I876_RS07955	COG2925	Exonuclease
I876_RS08010	COG1643	Atp-dependent helicase
I876_RS08030	COG0604	alcohol dehydrogenase
I876_RS08030	COG3321	synthase
I876_RS08035	COG0328	RNA-DNA hybrid ribonuclease activity
I876_RS08040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I876_RS08060	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I876_RS08065	COG1136	(ABC) transporter
I876_RS08070	COG4591	ABC-type transport system involved in lipoprotein release permease component
I876_RS08075	COG1301	dicarboxylic acid transport
I876_RS08085	COG3724	N-succinylarginine dihydrolase activity
I876_RS08090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I876_RS08105	COG0746	molybdenum cofactor guanylyltransferase activity
I876_RS08110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I876_RS08115	COG0243	molybdopterin cofactor binding
I876_RS08120	COG2153	protein acetylation
I876_RS08135	COG1530	ribonuclease E activity
I876_RS08150	COG0424	maF-like protein
I876_RS08155	COG1399	metal-binding, possibly nucleic acid-binding protein
I876_RS08165	COG0416	fatty acid biosynthetic process
I876_RS08170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I876_RS08175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I876_RS08185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I876_RS08190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I876_RS08200	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I876_RS08215	COG0084	hydrolase, TatD family'
I876_RS08225	COG0702	epimerase
I876_RS08230	COG3706	GGDEF domain
I876_RS08250	COG1028	Short-chain dehydrogenase reductase Sdr
I876_RS08255	COG0596	Alpha beta hydrolase
I876_RS08265	COG0183	Belongs to the thiolase family
I876_RS08270	COG1960	acyl-CoA dehydrogenase activity
I876_RS08290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I876_RS08300	COG0246	Mannitol dehydrogenase
I876_RS08320	COG0668	transmembrane transport
I876_RS08325	COG4771	TonB-dependent receptor
I876_RS08345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I876_RS08345	COG2205	protein histidine kinase activity
I876_RS08350	COG3437	response regulator, receiver
I876_RS08360	COG0195	Participates in both transcription termination and antitermination
I876_RS08375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I876_RS08390	COG1187	pseudouridine synthase activity
I876_RS08400	COG3153	acetyltransferase
I876_RS08400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I876_RS08470	COG1032	radical SAM domain protein
I876_RS08485	COG4771	TonB-dependent receptor
I876_RS08490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I876_RS08500	COG4134	Bacterial extracellular solute-binding protein
I876_RS08510	COG4136	ATPase activity
I876_RS08515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I876_RS08535	COG2203	Gaf domain
I876_RS08535	COG4251	negative regulation of phosphorylation
I876_RS08535	COG5001	Diguanylate cyclase
I876_RS08535	COG3706	GGDEF domain
I876_RS08575	COG2801	Transposase and inactivated derivatives
I876_RS08585	COG1902	pentaerythritol trinitrate reductase activity
I876_RS08595	COG2867	negative regulation of translational initiation
I876_RS08600	COG2914	Belongs to the UPF0125 (RnfH) family
I876_RS08610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I876_RS08615	COG4771	TonB-dependent receptor
I876_RS08620	COG0457	Tetratricopeptide repeat
I876_RS08635	COG0574	Belongs to the PEP-utilizing enzyme family
I876_RS08635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I876_RS08670	COG2850	peptidyl-arginine hydroxylation
I876_RS08680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I876_RS08685	COG2915	High frequency lysogenization protein hflD homolog
I876_RS08690	COG0482	sulfurtransferase activity
I876_RS08695	COG1187	pseudouridine synthase activity
I876_RS08705	COG1278	Cold shock
I876_RS08710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I876_RS08715	COG0542	response to heat
I876_RS08720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I876_RS08725	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I876_RS08730	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I876_RS08735	COG0492	ferredoxin-NADP+ reductase activity
I876_RS08745	COG3091	SprT-like family
I876_RS08750	COG0616	signal peptide processing
I876_RS08765	COG0778	Nitroreductase
I876_RS08775	COG0252	asparaginase activity
I876_RS08780	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I876_RS08785	COG0321	lipoyl(octanoyl) transferase activity
I876_RS08790	COG2921	Belongs to the UPF0250 family
I876_RS08795	COG1686	Belongs to the peptidase S11 family
I876_RS08800	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I876_RS08805	COG0772	Belongs to the SEDS family
I876_RS08810	COG0768	penicillin binding
I876_RS08815	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I876_RS08820	COG0799	negative regulation of ribosome biogenesis
I876_RS08825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I876_RS08830	COG1466	dna polymerase III delta subunit
I876_RS08835	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I876_RS08840	COG0495	leucyl-tRNA aminoacylation
I876_RS08855	COG1067	ATP-dependent peptidase activity
I876_RS08860	COG0596	Alpha beta hydrolase
I876_RS08875	COG1534	Rna-binding protein
I876_RS08880	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I876_RS08885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I876_RS08890	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I876_RS08895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I876_RS08900	COG0149	triose-phosphate isomerase activity
I876_RS08905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I876_RS08915	COG5001	Diguanylate cyclase
I876_RS08915	COG3300	MHYT domain
I876_RS08935	COG1597	lipid kinase activity
I876_RS08935	COG1803	Methylglyoxal synthase
I876_RS08945	COG1028	Short-chain dehydrogenase reductase Sdr
I876_RS08950	COG0561	phosphatase activity
I876_RS08965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I876_RS08970	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I876_RS08975	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I876_RS08990	COG1185	polyribonucleotide nucleotidyltransferase activity
I876_RS09025	COG3547	Transposase (IS116 IS110 IS902 family)
I876_RS09035	COG3547	Transposase (IS116 IS110 IS902 family)
I876_RS09125	COG3550	peptidyl-serine autophosphorylation
I876_RS09130	COG2801	Transposase and inactivated derivatives
I876_RS09260	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I876_RS09265	COG1196	nuclear chromosome segregation
I876_RS09275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I876_RS09290	COG1132	(ABC) transporter
I876_RS09295	COG1663	tetraacyldisaccharide 4'-kinase activity
I876_RS09330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I876_RS09335	COG0435	Glutathione S-transferase
I876_RS09340	COG1741	Belongs to the pirin family
I876_RS09345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I876_RS09355	COG0372	Belongs to the citrate synthase family
I876_RS09365	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I876_RS09370	COG1053	succinate dehydrogenase
I876_RS09375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I876_RS09380	COG0567	Dehydrogenase, E1 component
I876_RS09385	COG0508	dehydrogenase complex catalyzes the overall conversion of
I876_RS09425	COG4667	esterase of the alpha-beta hydrolase superfamily
I876_RS09445	COG0366	Alpha amylase catalytic
I876_RS09470	COG1028	Short-chain dehydrogenase reductase Sdr
I876_RS09475	COG2267	carboxylic ester hydrolase activity
I876_RS09485	COG0616	signal peptide processing
I876_RS09505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I876_RS09510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I876_RS09515	COG0386	Belongs to the glutathione peroxidase family
I876_RS09520	COG2084	Dehydrogenase
I876_RS09530	COG1960	acyl-CoA dehydrogenase activity
I876_RS09535	COG1024	Enoyl-CoA hydratase
I876_RS09540	COG2226	methyltransferase
I876_RS09545	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I876_RS09550	COG3083	sulfuric ester hydrolase activity
I876_RS09555	COG3082	Protein of unknown function (DUF1414)
I876_RS09560	COG3081	Nucleoid-associated protein
I876_RS09590	COG3275	phosphorelay sensor kinase activity
I876_RS09595	COG3279	Response regulator of the LytR AlgR family
I876_RS09600	COG0205	6-phosphofructokinase activity
I876_RS09610	COG3344	reverse transcriptase
I876_RS09660	COG2201	protein-glutamate methylesterase activity
I876_RS09685	COG0675	Transposase, IS605 OrfB family
I876_RS09730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I876_RS09785	COG3321	synthase
I876_RS09785	COG0604	alcohol dehydrogenase
I876_RS09785	COG4221	oxidoreductase activity
I876_RS09785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I876_RS09790	COG4221	oxidoreductase activity
I876_RS09795	COG0583	DNA-binding transcription factor activity
I876_RS09805	COG3550	peptidyl-serine autophosphorylation
I876_RS09810	COG3550	peptidyl-serine autophosphorylation
I876_RS09835	COG3039	Transposase
I876_RS09845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I876_RS09860	COG2205	protein histidine kinase activity
I876_RS09860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I876_RS09870	COG1054	Belongs to the UPF0176 family
I876_RS09880	COG0513	Belongs to the DEAD box helicase family
I876_RS09890	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I876_RS09895	COG0583	DNA-binding transcription factor activity
I876_RS09915	COG1760	l-serine dehydratase
I876_RS09940	COG1322	Protein conserved in bacteria
I876_RS09945	COG1404	Belongs to the peptidase S8 family
I876_RS09950	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I876_RS09955	COG0022	dehydrogenase e1 component
I876_RS09965	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I876_RS09970	COG0515	serine threonine protein kinase
I876_RS09975	COG1946	Acyl-CoA thioesterase
I876_RS09985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I876_RS09995	COG1956	GAF domain-containing protein
I876_RS10010	COG0793	Belongs to the peptidase S41A family
I876_RS10015	COG0733	neurotransmitter:sodium symporter activity
I876_RS10020	COG1757	Na H antiporter
I876_RS10025	COG0308	aminopeptidase N
I876_RS10055	COG2902	Dehydrogenase
I876_RS10060	COG0167	dihydroorotate dehydrogenase activity
I876_RS10075	COG0488	(ABC) transporter
I876_RS10085	COG3130	regulation of translation
I876_RS10090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I876_RS10100	COG0415	Belongs to the DNA photolyase family
I876_RS10120	COG2059	Chromate
I876_RS10135	COG3300	MHYT domain
I876_RS10135	COG5001	Diguanylate cyclase
I876_RS10140	COG0840	transmembrane signaling receptor activity
I876_RS10200	COG1192	Involved in chromosome partitioning
I876_RS10215	COG1484	DNA-dependent DNA replication
I876_RS10220	COG0415	Belongs to the DNA photolyase family
I876_RS10235	COG0415	Belongs to the DNA photolyase family
I876_RS10240	COG3046	protein related to deoxyribodipyrimidine photolyase
I876_RS10250	COG4974	Belongs to the 'phage' integrase family
I876_RS10260	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I876_RS10265	COG0589	response to stress
I876_RS10275	COG0069	glutamate synthase activity
I876_RS10290	COG2193	ferroxidase activity
I876_RS10300	COG3278	Belongs to the heme-copper respiratory oxidase family
I876_RS10315	COG2010	Cytochrome c
I876_RS10340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I876_RS10345	COG0589	response to stress
I876_RS10350	COG0037	tRNA processing
I876_RS10355	COG1752	Esterase of the alpha-beta hydrolase superfamily
I876_RS10375	COG1280	lysine exporter protein (LysE YggA)
I876_RS10385	COG2897	thiosulfate sulfurtransferase activity
I876_RS10390	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I876_RS10395	COG3148	PFAM DTW domain containing protein
I876_RS10470	COG0582	viral genome integration into host DNA
I876_RS10495	COG0322	excinuclease ABC activity
I876_RS10500	COG2197	response regulator
I876_RS10505	COG0436	Aminotransferase
I876_RS10525	COG2259	Doxx family
I876_RS10530	COG0583	DNA-binding transcription factor activity
I876_RS10545	COG0670	Belongs to the BI1 family
I876_RS10550	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I876_RS10565	COG2920	part of a sulfur-relay system
I876_RS10600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I876_RS10610	COG0531	amino acid
I876_RS10610	COG1674	ftsk spoiiie
I876_RS10620	COG0686	Belongs to the AlaDH PNT family
I876_RS10625	COG0284	orotidine-5'-phosphate decarboxylase activity
I876_RS10630	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I876_RS10645	COG0776	regulation of translation
I876_RS10650	COG0539	negative regulation of cytoplasmic translation
I876_RS10655	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I876_RS10660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I876_RS10665	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I876_RS10675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I876_RS10680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I876_RS10685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I876_RS10690	COG0633	Ferredoxin
I876_RS10725	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I876_RS10730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I876_RS10740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I876_RS10750	COG4783	chaperone-mediated protein folding
I876_RS10760	COG1393	Belongs to the ArsC family
I876_RS10775	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I876_RS10790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I876_RS10800	COG1960	acyl-CoA dehydrogenase activity
I876_RS10825	COG0572	uridine kinase
I876_RS10830	COG3769	mannosylglycerate metabolic process
I876_RS10835	COG1215	transferase activity, transferring glycosyl groups
I876_RS10840	COG0366	Alpha amylase catalytic
I876_RS10850	COG0303	'Molybdopterin
I876_RS10855	COG0534	Mate efflux family protein
I876_RS10870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I876_RS10875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I876_RS10910	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I876_RS10955	COG0405	Gamma-glutamyltransferase
I876_RS10960	COG1024	Enoyl-CoA hydratase
I876_RS11005	COG1448	Aminotransferase
I876_RS11025	COG1671	Belongs to the UPF0178 family
I876_RS11030	COG1028	Short-chain dehydrogenase reductase Sdr
I876_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
I876_RS11040	COG1960	acyl-CoA dehydrogenase activity
I876_RS11045	COG0662	Cupin 2, conserved barrel domain protein
I876_RS11045	COG2207	Transcriptional regulator
I876_RS11050	COG4771	TonB-dependent receptor
I876_RS11060	COG1505	serine-type exopeptidase activity
I876_RS11070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I876_RS11100	COG0596	Alpha beta hydrolase
I876_RS11110	COG0716	FMN binding
I876_RS11120	COG0735	belongs to the Fur family
I876_RS11130	COG1984	allophanate hydrolase subunit 2
I876_RS11135	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I876_RS11140	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I876_RS11145	COG2996	Protein conserved in bacteria
I876_RS11150	COG1765	OsmC-like protein
I876_RS11155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I876_RS11165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I876_RS11180	COG0436	Aminotransferase
I876_RS11185	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I876_RS11190	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I876_RS11200	COG2010	Cytochrome c
I876_RS11200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I876_RS11205	COG2080	2 iron, 2 sulfur cluster binding
I876_RS11230	COG1073	alpha beta
I876_RS11235	COG2207	Transcriptional regulator
I876_RS11245	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I876_RS11250	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I876_RS11275	COG3012	SEC-C Motif Domain Protein
I876_RS11280	COG0604	alcohol dehydrogenase
I876_RS11290	COG1960	acyl-CoA dehydrogenase activity
I876_RS11300	COG4771	TonB-dependent receptor
I876_RS11325	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I876_RS11345	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I876_RS11355	COG0521	Mo-molybdopterin cofactor biosynthetic process
I876_RS11370	COG2161	toxin-antitoxin pair type II binding
I876_RS11385	COG0436	Aminotransferase
I876_RS11390	COG3268	Saccharopine dehydrogenase
I876_RS11395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I876_RS11410	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I876_RS11415	COG4206	TonB-dependent receptor
I876_RS11425	COG5006	permease, DMT superfamily
I876_RS11440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I876_RS11445	COG1074	ATP-dependent DNA helicase activity
I876_RS11450	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I876_RS11465	COG1022	Amp-dependent synthetase and ligase
I876_RS11470	COG2203	Gaf domain
I876_RS11470	COG3706	GGDEF domain
I876_RS11470	COG4251	negative regulation of phosphorylation
I876_RS11470	COG5001	Diguanylate cyclase
I876_RS11490	COG0583	DNA-binding transcription factor activity
I876_RS11505	COG0640	Transcriptional regulator
I876_RS11525	COG2204	response regulator
I876_RS11535	COG4251	negative regulation of phosphorylation
I876_RS11540	COG0784	Response regulator, receiver
I876_RS11545	COG2205	protein histidine kinase activity
I876_RS11545	COG0784	Response regulator, receiver
I876_RS11570	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I876_RS11595	COG3139	Protein of unknown function (DUF1315)
I876_RS11610	COG1115	amino acid carrier protein
I876_RS11615	COG2866	Carboxypeptidase
I876_RS11635	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I876_RS11645	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I876_RS11650	COG1640	4-alpha-glucanotransferase
I876_RS11655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I876_RS11660	COG0676	glucose-6-phosphate 1-epimerase activity
I876_RS11665	COG0800	Aldolase
I876_RS11675	COG0129	dihydroxy-acid dehydratase activity
I876_RS11685	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I876_RS11690	COG1737	Transcriptional regulator
I876_RS11695	COG0469	pyruvate kinase activity
I876_RS11700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I876_RS11725	COG2823	Periplasmic or secreted lipoprotein
I876_RS11755	COG3665	Urea carboxylase-associated protein
I876_RS11775	COG1028	Short-chain dehydrogenase reductase Sdr
I876_RS11780	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I876_RS11790	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I876_RS11805	COG2721	sulfolactate sulfo-lyase activity
I876_RS11810	COG1904	glucuronate isomerase
I876_RS11815	COG0246	Mannitol dehydrogenase
I876_RS11820	COG0800	Aldolase
I876_RS11825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I876_RS11830	COG2755	lipolytic protein G-D-S-L family
I876_RS11840	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I876_RS11850	COG4677	pectinesterase activity
I876_RS11870	COG2356	endonuclease I
I876_RS11875	COG0840	transmembrane signaling receptor activity
I876_RS11890	COG0583	DNA-binding transcription factor activity
I876_RS11895	COG1979	alcohol dehydrogenase
I876_RS11900	COG5001	Diguanylate cyclase
I876_RS11910	COG3437	response regulator, receiver
I876_RS11910	COG0784	Response regulator, receiver
I876_RS11930	COG0471	metal ion transport
I876_RS11940	COG0489	protein tyrosine kinase activity
I876_RS11945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I876_RS11945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I876_RS11950	COG0668	transmembrane transport
I876_RS11955	COG2226	methyltransferase
I876_RS11960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I876_RS11965	COG0741	lytic transglycosylase activity
I876_RS11965	COG1388	LysM domain
I876_RS11990	COG0215	cysteine-tRNA ligase activity
I876_RS11995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I876_RS12005	COG1785	Belongs to the alkaline phosphatase family
I876_RS12010	COG1785	Belongs to the alkaline phosphatase family
I876_RS12025	COG2268	Band 7 protein
I876_RS12030	COG0583	DNA-binding transcription factor activity
I876_RS12035	COG1028	Short-chain dehydrogenase reductase Sdr
I876_RS12050	COG1733	regulation of RNA biosynthetic process
I876_RS12055	COG0604	alcohol dehydrogenase
I876_RS12060	COG0753	catalase activity
I876_RS12065	COG0604	alcohol dehydrogenase
I876_RS12095	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I876_RS12100	COG1286	toxin biosynthetic process
I876_RS12105	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I876_RS12110	COG0285	dihydrofolate synthase activity
I876_RS12140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I876_RS12160	COG3609	addiction module antidote protein, CC2985 family
I876_RS12165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I876_RS12170	COG0318	PFAM AMP-dependent synthetase and ligase
I876_RS12180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I876_RS12180	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I876_RS12215	COG0789	Transcriptional regulator
I876_RS12220	COG0604	alcohol dehydrogenase
I876_RS12235	COG1119	ATPase activity
I876_RS12240	COG2031	fatty acid transporter
I876_RS12245	COG2205	protein histidine kinase activity
I876_RS12245	COG0784	Response regulator, receiver
I876_RS12245	COG5002	protein histidine kinase activity
I876_RS12255	COG0612	Peptidase, M16
I876_RS12270	COG3101	peptidyl-lysine hydroxylation
I876_RS12295	COG0446	pyridine nucleotide-disulphide oxidoreductase
I876_RS12295	COG1902	pentaerythritol trinitrate reductase activity
I876_RS12330	COG4399	Belongs to the UPF0754 family
I876_RS12355	COG1770	oligopeptidase
I876_RS12360	COG2186	Transcriptional regulator
I876_RS12370	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I876_RS12375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I876_RS12385	COG2983	Belongs to the UPF0260 family
I876_RS12390	COG0179	Fumarylacetoacetate (FAA) hydrolase
I876_RS12405	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I876_RS12410	COG0318	PFAM AMP-dependent synthetase and ligase
I876_RS12415	COG2267	carboxylic ester hydrolase activity
I876_RS12430	COG1214	PFAM Peptidase M22, glycoprotease
I876_RS12435	COG1199	ATP-dependent helicase activity
I876_RS12485	COG4771	TonB-dependent receptor
I876_RS12495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I876_RS12500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I876_RS12505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I876_RS12510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I876_RS12510	COG0131	Imidazoleglycerol-phosphate dehydratase
I876_RS12515	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I876_RS12545	COG2116	formate transmembrane transporter activity
I876_RS12550	COG0612	Peptidase, M16
I876_RS12575	COG0326	Molecular chaperone. Has ATPase activity
I876_RS12580	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I876_RS12600	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I876_RS12605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I876_RS12615	COG3220	belongs to the UPF0276 family
I876_RS12625	COG0577	efflux transmembrane transporter activity
I876_RS12625	COG1136	(ABC) transporter
I876_RS12635	COG4251	negative regulation of phosphorylation
I876_RS12635	COG5001	Diguanylate cyclase
I876_RS12635	COG3706	GGDEF domain
I876_RS12635	COG2203	Gaf domain
I876_RS12655	COG1183	phosphatidylcholine synthase activity
I876_RS12670	COG0457	Tetratricopeptide repeat
I876_RS12675	COG0277	FAD linked oxidase domain protein
I876_RS12680	COG0542	response to heat
I876_RS12705	COG1595	DNA-templated transcription, initiation
I876_RS12720	COG4221	oxidoreductase activity
I876_RS12735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I876_RS12745	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I876_RS12755	COG0142	geranyltranstransferase activity
I876_RS12765	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I876_RS12770	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I876_RS12780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I876_RS12795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I876_RS12795	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I876_RS12810	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I876_RS12815	COG0488	(ABC) transporter
I876_RS12825	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I876_RS12835	COG0560	Phosphoserine phosphatase
I876_RS12845	COG0084	hydrolase, TatD family'
I876_RS12855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I876_RS12860	COG0571	ribonuclease III activity
I876_RS12890	COG1595	DNA-templated transcription, initiation
I876_RS12895	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I876_RS12910	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I876_RS12990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I876_RS12995	COG1047	Peptidyl-prolyl cis-trans
I876_RS13005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I876_RS13010	COG0196	riboflavin kinase activity
I876_RS13015	COG0728	peptidoglycan biosynthetic process
I876_RS13020	COG0268	Binds directly to 16S ribosomal RNA
I876_RS13040	COG0385	Bile acid
I876_RS13070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I876_RS13075	COG0776	regulation of translation
I876_RS13080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I876_RS13085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I876_RS13090	COG0740	serine-type endopeptidase activity
I876_RS13095	COG0544	peptidyl-prolyl cis-trans isomerase activity
I876_RS13130	COG1720	tRNA m6t6A37 methyltransferase activity
I876_RS13140	COG1234	tRNA 3'-trailer cleavage
I876_RS13150	COG0123	including yeast histone deacetylase and acetoin utilization protein
I876_RS13175	COG0517	IMP dehydrogenase activity
I876_RS13175	COG0516	GMP reductase activity
I876_RS13180	COG1570	exodeoxyribonuclease VII activity
I876_RS13200	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I876_RS13205	COG2976	Protein conserved in bacteria
I876_RS13230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I876_RS13240	COG2166	iron-sulfur cluster assembly
I876_RS13255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I876_RS13260	COG0719	Fe-S assembly protein
I876_RS13265	COG0396	ATPase activity
I876_RS13270	COG0719	Fe-S assembly protein
I876_RS13275	COG1104	cysteine desulfurase activity
I876_RS13280	COG1959	2 iron, 2 sulfur cluster binding
I876_RS13285	COG2072	flavoprotein involved in K transport
I876_RS13290	COG1045	serine acetyltransferase
I876_RS13295	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I876_RS13300	COG0483	inositol monophosphate 1-phosphatase activity
I876_RS13315	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I876_RS13320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I876_RS13325	COG1862	Preprotein translocase
I876_RS13330	COG0343	queuine tRNA-ribosyltransferase activity
I876_RS13350	COG1842	Phage shock protein A
I876_RS13355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I876_RS13375	COG0754	glutathionylspermidine amidase activity
I876_RS13405	COG2066	Belongs to the glutaminase family
I876_RS13410	COG1785	Belongs to the alkaline phosphatase family
I876_RS13415	COG0745	RESPONSE REGULATOR receiver
I876_RS13520	COG0438	transferase activity, transferring glycosyl groups
I876_RS13535	COG0367	asparagine synthase
I876_RS13540	COG0438	transferase activity, transferring glycosyl groups
I876_RS13560	COG0110	maltose O-acetyltransferase activity
I876_RS13565	COG2244	polysaccharide biosynthetic process
I876_RS13590	COG2327	Polysaccharide pyruvyl transferase
I876_RS13630	COG0489	protein tyrosine kinase activity
I876_RS13640	COG3409	Peptidoglycan-binding domain 1 protein
I876_RS13640	COG3267	Type II secretory pathway component ExeA
I876_RS13645	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I876_RS13645	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I876_RS13675	COG1560	Kdo2-lipid A biosynthetic process
I876_RS13690	COG1960	acyl-CoA dehydrogenase activity
I876_RS13705	COG3300	MHYT domain
I876_RS13705	COG5001	Diguanylate cyclase
I876_RS13710	COG1435	thymidine kinase activity
I876_RS13720	COG1609	Transcriptional regulator
I876_RS13725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I876_RS13760	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I876_RS13765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I876_RS13770	COG1250	3-hydroxyacyl-CoA dehydrogenase
I876_RS13770	COG1024	Enoyl-CoA hydratase
I876_RS13785	COG1012	belongs to the aldehyde dehydrogenase family
I876_RS13805	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I876_RS13810	COG0789	Transcriptional regulator
I876_RS13840	COG1960	acyl-CoA dehydrogenase activity
I876_RS13865	COG0745	RESPONSE REGULATOR receiver
I876_RS13870	COG2205	protein histidine kinase activity
I876_RS13910	COG2080	2 iron, 2 sulfur cluster binding
I876_RS13915	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I876_RS13920	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I876_RS13940	COG1028	Short-chain dehydrogenase reductase Sdr
I876_RS13945	COG4221	oxidoreductase activity
I876_RS13950	COG0693	protein deglycase activity
I876_RS13955	COG1295	ribonuclease BN
I876_RS13995	COG2814	Major facilitator Superfamily
I876_RS14010	COG0514	ATP-dependent DNA helicase (RecQ)
I876_RS14040	COG4251	negative regulation of phosphorylation
I876_RS14060	COG0830	nickel cation binding
I876_RS14085	COG0829	nickel cation binding
I876_RS14120	COG0784	Response regulator, receiver
I876_RS14120	COG2198	Histidine kinase
I876_RS14120	COG2205	protein histidine kinase activity
I876_RS14125	COG0745	RESPONSE REGULATOR receiver
I876_RS14130	COG1484	DNA-dependent DNA replication
I876_RS14140	COG3177	Filamentation induced by cAMP protein fic
I876_RS14175	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I876_RS14270	COG4772	TonB-dependent receptor
I876_RS14315	COG4372	Transposase
I876_RS14340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I876_RS14345	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I876_RS14350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I876_RS14370	COG3313	Fe-S protein
I876_RS14405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I876_RS14410	COG0508	dehydrogenase complex catalyzes the overall conversion of
I876_RS14415	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I876_RS14430	COG3023	N-Acetylmuramoyl-L-alanine amidase
I876_RS14435	COG3577	Aspartyl protease
I876_RS14440	COG0157	Belongs to the NadC ModD family
I876_RS14445	COG4969	Belongs to the N-Me-Phe pilin family
I876_RS14450	COG1459	type II secretion system
I876_RS14455	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I876_RS14460	COG0237	dephospho-CoA kinase activity
I876_RS14460	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I876_RS14465	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I876_RS14470	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I876_RS14475	COG3608	succinylglutamate desuccinylase aspartoacylase
I876_RS14480	COG0494	nUDIX hydrolase
I876_RS14490	COG0739	heme binding
I876_RS14495	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I876_RS14500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I876_RS14505	COG0849	cell division
I876_RS14510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I876_RS14515	COG1181	Belongs to the D-alanine--D-alanine ligase family
I876_RS14520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I876_RS14530	COG0772	Belongs to the SEDS family
I876_RS14535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I876_RS14545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I876_RS14550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I876_RS14555	COG0768	penicillin binding
I876_RS14560	COG3116	cell division
I876_RS14570	COG2001	Belongs to the MraZ family
I876_RS14610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I876_RS14610	COG0678	peroxiredoxin activity
I876_RS14635	COG2204	response regulator
I876_RS14640	COG0784	Response regulator, receiver
I876_RS14640	COG2205	protein histidine kinase activity
I876_RS14665	COG0668	transmembrane transport
I876_RS14670	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I876_RS14675	COG0189	ligase activity
I876_RS14680	COG1678	Uncharacterized ACR, COG1678
I876_RS14685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I876_RS14710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I876_RS14715	COG0762	integral membrane protein
I876_RS14725	COG1902	pentaerythritol trinitrate reductase activity
I876_RS14725	COG0446	pyridine nucleotide-disulphide oxidoreductase
I876_RS14740	COG0625	glutathione transferase activity
I876_RS14750	COG1764	response to oxidative stress
I876_RS14755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I876_RS14770	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I876_RS14775	COG1396	sequence-specific DNA binding
I876_RS14780	COG2814	Major facilitator Superfamily
I876_RS14785	COG0724	RNA recognition motif
I876_RS14810	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I876_RS14815	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I876_RS14820	COG0083	homoserine kinase activity
I876_RS14835	COG0583	DNA-binding transcription factor activity
I876_RS14850	COG0640	Transcriptional regulator
I876_RS14860	COG0431	NADPH-dependent FMN reductase
I876_RS14865	COG0798	PFAM Bile acid sodium symporter
I876_RS14870	COG2201	protein-glutamate methylesterase activity
I876_RS14875	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I876_RS14885	COG0642	Histidine kinase
I876_RS14900	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I876_RS14930	COG1748	Saccharopine dehydrogenase
I876_RS14945	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I876_RS14950	COG3107	peptidoglycan biosynthetic process
I876_RS14960	COG0438	transferase activity, transferring glycosyl groups
I876_RS14970	COG2823	Periplasmic or secreted lipoprotein
I876_RS14990	COG4585	Histidine kinase
I876_RS14995	COG2197	response regulator
I876_RS15010	COG4771	TonB-dependent receptor
I876_RS15020	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I876_RS15025	COG0372	Belongs to the citrate synthase family
I876_RS15030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I876_RS15035	COG2828	Protein conserved in bacteria
I876_RS15040	COG2199	diguanylate cyclase activity
I876_RS15040	COG2203	Gaf domain
I876_RS15045	COG1940	carbohydrate kinase activity
I876_RS15065	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I876_RS15085	COG2198	Histidine kinase
I876_RS15085	COG5002	protein histidine kinase activity
I876_RS15085	COG0784	Response regulator, receiver
I876_RS15090	COG3023	N-Acetylmuramoyl-L-alanine amidase
I876_RS15095	COG0070	glutamate synthase
I876_RS15095	COG0067	glutamate synthase
I876_RS15095	COG0069	glutamate synthase activity
I876_RS15100	COG0493	'glutamate synthase
I876_RS15115	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I876_RS15120	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I876_RS15125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I876_RS15130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I876_RS15145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I876_RS15150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I876_RS15160	COG4942	peptidase
I876_RS15165	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I876_RS15170	COG0738	Major facilitator superfamily
I876_RS15180	COG1902	pentaerythritol trinitrate reductase activity
I876_RS15200	COG0625	glutathione transferase activity
I876_RS15225	COG2894	cell division
I876_RS15230	COG0850	regulation of cytokinetic process
I876_RS15240	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I876_RS15255	COG1981	membrane
I876_RS15270	COG1914	H( )-stimulated, divalent metal cation uptake system
I876_RS15285	COG1217	gtp-binding protein TYPA
I876_RS15290	COG0174	glutamine synthetase
I876_RS15300	COG3852	Histidine kinase
I876_RS15305	COG2204	response regulator
I876_RS15310	COG3437	response regulator, receiver
I876_RS15350	COG3850	Histidine kinase
I876_RS15350	COG3437	response regulator, receiver
I876_RS15350	COG4999	Histidine kinase
I876_RS15350	COG2205	protein histidine kinase activity
I876_RS15355	COG0525	valine-tRNA ligase activity
I876_RS15360	COG2927	DNA polymerase III (CHI subunit)
I876_RS15365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I876_RS15370	COG0795	lipopolysaccharide-transporting ATPase activity
I876_RS15375	COG0795	lipopolysaccharide-transporting ATPase activity
I876_RS15470	COG3250	beta-galactosidase activity
I876_RS15480	COG4948	Mandelate Racemase Muconate Lactonizing
I876_RS15485	COG3661	Belongs to the glycosyl hydrolase 67 family
I876_RS15500	COG2199	diguanylate cyclase activity
I876_RS15500	COG2203	Gaf domain
I876_RS15530	COG0673	inositol 2-dehydrogenase activity
I876_RS15535	COG2205	protein histidine kinase activity
I876_RS15535	COG2198	Histidine kinase
I876_RS15535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I876_RS15535	COG0784	Response regulator, receiver
I876_RS15540	COG0628	permease
I876_RS15555	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I876_RS15560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I876_RS15565	COG4558	Periplasmic binding protein
I876_RS15575	COG4206	TonB-dependent receptor
I876_RS15585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I876_RS15610	COG4447	cellulose binding
I876_RS15620	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I876_RS15640	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I876_RS15680	COG1131	(ABC) transporter
I876_RS15700	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I876_RS15740	COG2205	protein histidine kinase activity
I876_RS15750	COG3901	Regulator of nitric oxide reductase transcription
I876_RS15750	COG0348	domain, Protein
I876_RS15760	COG2197	response regulator
I876_RS15790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I876_RS15805	COG4771	TonB-dependent receptor
I876_RS15815	COG0583	DNA-binding transcription factor activity
I876_RS15820	COG1304	FMN binding
I876_RS15825	COG0277	FAD linked oxidase domain protein
I876_RS15835	COG1462	curli production assembly transport component CsgG
I876_RS15865	COG2197	response regulator
I876_RS15875	COG1028	Short-chain dehydrogenase reductase Sdr
I876_RS15890	COG0513	Belongs to the DEAD box helicase family
I876_RS15900	COG5001	Diguanylate cyclase
I876_RS15915	COG0800	Aldolase
I876_RS15935	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I876_RS15935	COG3264	Mechanosensitive ion channel
I876_RS15955	COG0840	transmembrane signaling receptor activity
I876_RS15980	COG0730	response to heat
I876_RS15985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I876_RS16000	COG4191	Histidine kinase
I876_RS16010	COG0417	DNA replication proofreading
I876_RS16020	COG0318	PFAM AMP-dependent synthetase and ligase
I876_RS16055	COG1309	transcriptional regulator
I876_RS16065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I876_RS16075	COG1573	uracil-dna glycosylase
I876_RS16080	COG5001	Diguanylate cyclase
I876_RS16080	COG3300	MHYT domain
I876_RS16100	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I876_RS16120	COG1983	PspC domain protein
I876_RS16125	COG1842	Phage shock protein A
I876_RS16135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I876_RS16175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I876_RS16185	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I876_RS16190	COG0204	Acyl-transferase
I876_RS16195	COG0204	Acyl-transferase
I876_RS16200	COG0668	transmembrane transport
I876_RS16215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I876_RS16220	COG0733	neurotransmitter:sodium symporter activity
I876_RS16235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I876_RS16260	COG0848	biopolymer transport protein
I876_RS16280	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I876_RS16290	COG1215	transferase activity, transferring glycosyl groups
I876_RS16300	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I876_RS16305	COG0702	epimerase
I876_RS16320	COG5002	protein histidine kinase activity
I876_RS16320	COG5001	Diguanylate cyclase
I876_RS16330	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I876_RS16340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I876_RS16350	COG0583	DNA-binding transcription factor activity
I876_RS16355	COG0121	glutamine amidotransferase
I876_RS16365	COG4682	membrane
I876_RS16385	COG1953	Uracil, thiamine, allantoin
I876_RS16390	COG4771	TonB-dependent receptor
I876_RS16400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I876_RS16405	COG0778	Nitroreductase
I876_RS16410	COG0596	Alpha beta hydrolase
I876_RS16415	COG0251	oxidation-reduction process
I876_RS16420	COG1335	isochorismatase
I876_RS16425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I876_RS16430	COG1309	transcriptional regulator
I876_RS16445	COG4628	conserved protein (DUF2132)
I876_RS16450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I876_RS16460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I876_RS16480	COG1477	protein flavinylation
I876_RS16485	COG2871	sodium ion transport
I876_RS16490	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I876_RS16495	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I876_RS16500	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I876_RS16505	COG1805	sodium ion transport
I876_RS16510	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I876_RS16515	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I876_RS16520	COG0545	Peptidyl-prolyl cis-trans isomerase
I876_RS16525	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I876_RS16540	COG0039	L-malate dehydrogenase activity
I876_RS16545	COG1438	arginine binding
I876_RS16570	COG0572	uridine kinase
I876_RS16575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I876_RS16600	COG2176	DNA-directed DNA polymerase activity
I876_RS16610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I876_RS16630	COG0189	ligase activity
I876_RS16640	COG0189	ligase activity
I876_RS16640	COG4067	protein conserved in archaea
I876_RS16655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I876_RS16665	COG1283	sodium-dependent phosphate transmembrane transporter activity
I876_RS16670	COG0667	Aldo Keto reductase
I876_RS16720	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I876_RS16730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I876_RS16780	COG2274	protein secretion by the type I secretion system
I876_RS16785	COG0583	DNA-binding transcription factor activity
I876_RS16810	COG1216	Glycosyl transferase, family 2
I876_RS16810	COG0438	transferase activity, transferring glycosyl groups
I876_RS16820	COG1091	dTDP-4-dehydrorhamnose reductase activity
I876_RS16830	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I876_RS16835	COG0457	Tetratricopeptide repeat
I876_RS17015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I876_RS17025	COG2161	toxin-antitoxin pair type II binding
I876_RS17035	COG0202	RNA polymerase activity
I876_RS17060	COG0201	protein transport
I876_RS17080	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I876_RS17115	COG0784	Response regulator, receiver
I876_RS17115	COG5002	protein histidine kinase activity
I876_RS17135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I876_RS17140	COG0557	exoribonuclease II activity
I876_RS17185	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I876_RS17200	COG0543	2 iron, 2 sulfur cluster binding
I876_RS17215	COG2234	aminopeptidase activity
I876_RS17225	COG4251	negative regulation of phosphorylation
I876_RS17235	COG1271	oxidase subunit
I876_RS17240	COG1294	oxidase, subunit
I876_RS17245	COG1522	sequence-specific DNA binding
I876_RS17255	COG1278	Cold shock
I876_RS17260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I876_RS17280	COG0339	signal peptide processing
I876_RS17285	COG2201	protein-glutamate methylesterase activity
I876_RS17295	COG3852	Histidine kinase
I876_RS17305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I876_RS17310	COG0243	molybdopterin cofactor binding
I876_RS17315	COG0823	Involved in the tonB-independent uptake of proteins
I876_RS17315	COG1506	peptidase
I876_RS17315	COG4946	Tricorn protease homolog
I876_RS17360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I876_RS17370	COG2197	response regulator
I876_RS17380	COG0189	ligase activity
I876_RS17400	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I876_RS17405	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I876_RS17410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I876_RS17425	COG0281	malic enzyme
I876_RS17435	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I876_RS17465	COG0456	acetyltransferase
I876_RS17475	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I876_RS17480	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I876_RS17485	COG2177	Part of the ABC transporter FtsEX involved in
I876_RS17490	COG2884	Cell division ATP-binding protein ftsE
I876_RS17495	COG0552	protein localization to endoplasmic reticulum
I876_RS17500	COG0742	ribosomal rna small subunit methyltransferase
I876_RS17510	COG2095	MarC family integral membrane protein
I876_RS17530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I876_RS17535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I876_RS17540	COG0617	tRNA 3'-terminal CCA addition
I876_RS17545	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I876_RS17560	COG0076	glutamate decarboxylase activity
I876_RS17575	COG0842	Transport permease protein
I876_RS17580	COG1131	(ABC) transporter
I876_RS17585	COG0745	RESPONSE REGULATOR receiver
I876_RS17590	COG2205	protein histidine kinase activity
I876_RS17595	COG4774	siderophore transport
I876_RS17615	COG1253	flavin adenine dinucleotide binding
I876_RS17625	COG1966	Carbon starvation protein
I876_RS17635	COG0657	acetylesterase activity
I876_RS17655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I876_RS17660	COG0049	tRNA binding
I876_RS17665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I876_RS17670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I876_RS17675	COG0085	RNA polymerase activity
I876_RS17680	COG0222	ribosome binding
I876_RS17685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I876_RS17690	COG0081	regulation of translation
I876_RS17695	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I876_RS17715	COG0250	Participates in transcription elongation, termination and antitermination
I876_RS17720	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I876_RS17730	COG1132	(ABC) transporter
I876_RS17735	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I876_RS17740	COG3590	peptidase
I876_RS17750	COG0513	Belongs to the DEAD box helicase family
I876_RS17755	COG0418	dihydroorotase activity
I876_RS17760	COG3040	lipid binding
I876_RS17765	COG4989	oxidoreductase activity
I876_RS17770	COG0346	lactoylglutathione lyase activity
I876_RS17775	COG0668	transmembrane transport
I876_RS17795	COG0302	gtp cyclohydrolase
I876_RS17805	COG2957	Belongs to the agmatine deiminase family
I876_RS17810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I876_RS17820	COG1201	RNA secondary structure unwinding
I876_RS17830	COG1793	dna ligase
I876_RS17835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I876_RS17840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I876_RS17855	COG0625	glutathione transferase activity
I876_RS17860	COG0625	glutathione transferase activity
I876_RS17870	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I876_RS17885	COG1012	belongs to the aldehyde dehydrogenase family
I876_RS17890	COG0028	Belongs to the TPP enzyme family
I876_RS17900	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I876_RS17905	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I876_RS17910	COG0330	HflC and HflK could
I876_RS17915	COG0330	HflC and HflK could
I876_RS17920	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I876_RS17925	COG1923	regulation of RNA biosynthetic process
I876_RS17930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I876_RS17945	COG0802	atpase or kinase
I876_RS17950	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I876_RS17950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I876_RS17955	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I876_RS17975	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I876_RS17980	COG0735	belongs to the Fur family
I876_RS18000	COG0305	Participates in initiation and elongation during chromosome replication
I876_RS18025	COG2258	MOSC domain
I876_RS18055	COG2198	Histidine kinase
I876_RS18055	COG2205	protein histidine kinase activity
I876_RS18055	COG0784	Response regulator, receiver
I876_RS18065	COG0577	efflux transmembrane transporter activity
I876_RS18065	COG1136	(ABC) transporter
I876_RS18075	COG0840	transmembrane signaling receptor activity
I876_RS18080	COG5002	protein histidine kinase activity
I876_RS18085	COG0840	transmembrane signaling receptor activity
I876_RS18110	COG1757	Na H antiporter
I876_RS18115	COG1472	Belongs to the glycosyl hydrolase 3 family
I876_RS18125	COG2723	6-phospho-beta-galactosidase activity
I876_RS18130	COG1609	Transcriptional regulator
I876_RS18135	COG0477	Major facilitator Superfamily
I876_RS18135	COG2814	Major facilitator Superfamily
I876_RS18140	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I876_RS18145	COG4988	ABC transporter
I876_RS18155	COG1294	oxidase, subunit
I876_RS18195	COG4319	ketosteroid isomerase
I876_RS18215	COG2375	cellular response to nickel ion
I876_RS18220	COG3237	CsbD-like
I876_RS18245	COG0596	Alpha beta hydrolase
I876_RS18245	COG0508	dehydrogenase complex catalyzes the overall conversion of
I876_RS18265	COG3038	cytochrome b561
I876_RS18275	COG1252	NADH dehydrogenase
I876_RS18290	COG0583	DNA-binding transcription factor activity
I876_RS18295	COG2067	long-chain fatty acid transport protein
I876_RS18300	COG2130	NADP-dependent
I876_RS18305	COG2203	Gaf domain
I876_RS18305	COG3706	GGDEF domain
I876_RS18305	COG4251	negative regulation of phosphorylation
I876_RS18305	COG5001	Diguanylate cyclase
I876_RS18310	COG2205	protein histidine kinase activity
I876_RS18310	COG0784	Response regulator, receiver
I876_RS18320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I876_RS18325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I876_RS18330	COG1349	DNA-binding transcription factor activity
I876_RS18335	COG0673	inositol 2-dehydrogenase activity
I876_RS18350	COG0697	spore germination
I876_RS18355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I876_RS18360	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I876_RS18365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I876_RS18370	COG1166	arginine decarboxylase activity
I876_RS18380	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I876_RS18435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I876_RS18440	COG0109	protoheme IX farnesyltransferase activity
I876_RS18460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I876_RS18475	COG1487	ribonuclease activity
I876_RS18505	COG3030	protein affecting phage T7 exclusion by the F plasmid
I876_RS18510	COG1324	tolerance protein
I876_RS18515	COG4232	protein-disulfide reductase activity
I876_RS18520	COG0739	heme binding
I876_RS18525	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I876_RS18530	COG0511	ligase activity, forming carbon-carbon bonds
I876_RS18535	COG0439	Biotin carboxylase
I876_RS18580	COG0154	amidase activity
I876_RS18595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I876_RS18600	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I876_RS18615	COG0151	Belongs to the GarS family
I876_RS18630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I876_RS18635	COG3954	Phosphoribulokinase
I876_RS18660	COG1501	Belongs to the glycosyl hydrolase 31 family
I876_RS18665	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I876_RS18675	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I876_RS18685	COG3031	protein transport across the cell outer membrane
I876_RS18695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I876_RS18700	COG1459	type II secretion system
I876_RS18705	COG2165	general secretion pathway protein
I876_RS18710	COG2165	general secretion pathway protein
I876_RS18720	COG4795	General secretion pathway protein
I876_RS18735	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I876_RS18750	COG1012	belongs to the aldehyde dehydrogenase family
I876_RS18760	COG1011	Hydrolase
I876_RS18765	COG0494	nUDIX hydrolase
I876_RS18770	COG1218	3'(2'),5'-bisphosphate nucleotidase
I876_RS18780	COG2943	transferase activity, transferring hexosyl groups
I876_RS18785	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I876_RS18795	COG3089	Belongs to the UPF0270 family
I876_RS18800	COG0429	hydrolase of the alpha beta-hydrolase fold
I876_RS18810	COG0488	(ABC) transporter
I876_RS18825	COG2900	Belongs to the SlyX family
I876_RS18835	COG0545	Peptidyl-prolyl cis-trans isomerase
I876_RS18845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I876_RS18850	COG2183	response to ionizing radiation
I876_RS18870	COG0596	Alpha beta hydrolase
I876_RS18875	COG1040	competence protein
I876_RS18895	COG1794	racemase activity, acting on amino acids and derivatives
I876_RS18905	COG0534	Mate efflux family protein
I876_RS18920	COG1999	signal sequence binding
I876_RS18925	COG0109	protoheme IX farnesyltransferase activity
I876_RS18930	COG1612	heme a metabolic process
I876_RS18950	COG1845	cytochrome c oxidase, subunit III
I876_RS18955	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I876_RS18960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I876_RS18965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I876_RS18975	COG3706	GGDEF domain
I876_RS18990	COG0129	dihydroxy-acid dehydratase activity
I876_RS19000	COG0606	chelatase, subunit chli
I876_RS19015	COG2814	Major facilitator Superfamily
I876_RS19025	COG0729	surface antigen
I876_RS19030	COG2911	Protein conserved in bacteria
I876_RS19055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I876_RS19065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I876_RS19085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I876_RS19110	COG1228	amidohydrolase
I876_RS19135	COG0425	Belongs to the sulfur carrier protein TusA family
I876_RS19150	COG1561	YicC-like family, N-terminal region
I876_RS19160	COG3550	peptidyl-serine autophosphorylation
I876_RS19165	COG3620	sequence-specific DNA binding
I876_RS19265	COG3177	Filamentation induced by cAMP protein fic
I876_RS19275	COG1609	Transcriptional regulator
I876_RS19290	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I876_RS19290	COG2199	diguanylate cyclase activity
I876_RS19320	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I876_RS19340	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I876_RS19345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I876_RS19365	COG1475	DNA binding
I876_RS19370	COG1192	Involved in chromosome partitioning
I876_RS19395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I876_RS19410	COG0706	membrane insertase activity
I876_RS19415	COG0594	ribonuclease P activity
I876_RS19420	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I876_RS19450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I876_RS19485	COG3447	MASE1 domain protein
I876_RS19485	COG5001	Diguanylate cyclase
I876_RS19485	COG5002	protein histidine kinase activity
I876_RS19520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I876_RS19525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I876_RS19530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway