locus-tag	class	description
I634_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I634_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I634_RS00040	COG2818	Glycosylase
I634_RS00050	COG3078	GTPase activator activity
I634_RS00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I634_RS00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I634_RS00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I634_RS00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I634_RS00085	COG0569	domain protein
I634_RS00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I634_RS00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I634_RS00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I634_RS00110	COG0758	DNA mediated transformation
I634_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
I634_RS00130	COG0408	coproporphyrinogen oxidase activity
I634_RS00135	COG3047	cAMP biosynthetic process
I634_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I634_RS00225	COG2234	aminopeptidase activity
I634_RS00230	COG0463	Glycosyl transferase, family 2
I634_RS00240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I634_RS00265	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I634_RS00295	COG3642	lipopolysaccharide core region biosynthetic process
I634_RS00300	COG0859	PFAM glycosyl transferase family 9
I634_RS00330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I634_RS00345	COG3161	chorismate lyase activity
I634_RS00350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I634_RS00370	COG0210	DNA helicase
I634_RS00400	COG1757	Na H antiporter
I634_RS00415	COG1959	2 iron, 2 sulfur cluster binding
I634_RS00420	COG0730	response to heat
I634_RS00435	COG4771	TonB-dependent receptor
I634_RS00455	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I634_RS00460	COG4988	ABC transporter
I634_RS00470	COG1271	oxidase subunit
I634_RS00480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I634_RS00480	COG0425	Belongs to the sulfur carrier protein TusA family
I634_RS00490	COG0450	alkyl hydroperoxide reductase
I634_RS00500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I634_RS00530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I634_RS00560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I634_RS00565	COG0842	Transport permease protein
I634_RS00565	COG1129	ABC transporter
I634_RS00570	COG0842	Transport permease protein
I634_RS00585	COG1960	acyl-CoA dehydrogenase activity
I634_RS00590	COG0583	DNA-binding transcription factor activity
I634_RS00600	COG3106	COG3106 Predicted ATPase
I634_RS00615	COG2184	nucleotidyltransferase activity
I634_RS00620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I634_RS00640	COG0352	thiamine-phosphate diphosphorylase activity
I634_RS00650	COG3071	HemY protein
I634_RS00655	COG2959	enzyme of heme biosynthesis
I634_RS00665	COG0181	hydroxymethylbilane synthase activity
I634_RS00670	COG3706	GGDEF domain
I634_RS00680	COG0194	GDP metabolic process
I634_RS00690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I634_RS00700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I634_RS00705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I634_RS00715	COG0678	peroxiredoxin activity
I634_RS00730	COG1178	ABC-type Fe3 transport system permease component
I634_RS00735	COG3842	ATPase activity
I634_RS00740	COG0668	transmembrane transport
I634_RS00745	COG2081	HI0933 family
I634_RS00765	COG4772	TonB-dependent receptor
I634_RS00870	COG0789	Transcriptional regulator
I634_RS00875	COG2963	transposase activity
I634_RS00880	COG2801	Transposase and inactivated derivatives
I634_RS00895	COG2200	EAL domain
I634_RS00900	COG0583	DNA-binding transcription factor activity
I634_RS00925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I634_RS00940	COG0427	acetyl-CoA hydrolase
I634_RS00945	COG0123	including yeast histone deacetylase and acetoin utilization protein
I634_RS00960	COG0840	transmembrane signaling receptor activity
I634_RS00970	COG3064	Membrane
I634_RS00980	COG5001	Diguanylate cyclase
I634_RS00980	COG5002	protein histidine kinase activity
I634_RS00995	COG0514	ATP-dependent DNA helicase (RecQ)
I634_RS01000	COG2239	Acts as a magnesium transporter
I634_RS01005	COG2962	Rard protein
I634_RS01015	COG0210	DNA helicase
I634_RS01025	COG1011	Hydrolase
I634_RS01030	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I634_RS01040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I634_RS01045	COG0019	diaminopimelate decarboxylase activity
I634_RS01075	COG0163	prenyltransferase activity
I634_RS01080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I634_RS01090	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I634_RS01110	COG1077	Cell shape determining protein MreB Mrl
I634_RS01120	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I634_RS01125	COG2814	Major facilitator Superfamily
I634_RS01130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I634_RS01155	COG1085	galactose-1-phosphate uridylyltransferase
I634_RS01160	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I634_RS01170	COG0629	single-stranded DNA binding
I634_RS01185	COG3250	beta-galactosidase activity
I634_RS01205	COG1349	DNA-binding transcription factor activity
I634_RS01250	COG3267	Type II secretory pathway component ExeA
I634_RS01250	COG3409	Peptidoglycan-binding domain 1 protein
I634_RS01260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I634_RS01265	COG1459	type II secretion system
I634_RS01275	COG2165	general secretion pathway protein
I634_RS01280	COG2165	general secretion pathway protein
I634_RS01310	COG1077	Cell shape determining protein MreB Mrl
I634_RS01315	COG1792	Involved in formation and maintenance of cell shape
I634_RS01320	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I634_RS01330	COG1530	ribonuclease E activity
I634_RS01340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I634_RS01345	COG0312	modulator of DNA gyrase
I634_RS01350	COG3028	Belongs to the UPF0307 family
I634_RS01355	COG0312	modulator of DNA gyrase
I634_RS01370	COG0745	RESPONSE REGULATOR receiver
I634_RS01375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I634_RS01375	COG4191	Histidine kinase
I634_RS01380	COG0297	glycogen (starch) synthase activity
I634_RS01390	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I634_RS01395	COG0596	Alpha beta hydrolase
I634_RS01445	COG5310	Homospermidine synthase
I634_RS01470	COG3251	PFAM MbtH domain protein
I634_RS01570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I634_RS01580	COG5002	protein histidine kinase activity
I634_RS01585	COG0745	RESPONSE REGULATOR receiver
I634_RS01605	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I634_RS01670	COG1017	nitric oxide dioxygenase activity
I634_RS01670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I634_RS01690	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I634_RS01720	COG0375	protein maturation
I634_RS01730	COG0409	Hydrogenase expression formation protein
I634_RS01740	COG0309	Hydrogenase expression formation protein (HypE)
I634_RS01745	COG0789	Transcriptional regulator
I634_RS01750	COG2217	Heavy metal translocating P-type atpase
I634_RS01820	COG0531	amino acid
I634_RS01830	COG2132	Multicopper oxidase
I634_RS01900	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I634_RS01920	COG0835	chemotaxis
I634_RS01930	COG0745	RESPONSE REGULATOR receiver
I634_RS01945	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I634_RS01960	COG0835	chemotaxis
I634_RS01970	COG0745	RESPONSE REGULATOR receiver
I634_RS01990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I634_RS02000	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I634_RS02010	COG0463	Glycosyl transferase, family 2
I634_RS02020	COG0745	RESPONSE REGULATOR receiver
I634_RS02025	COG5002	protein histidine kinase activity
I634_RS02070	COG0546	phosphoglycolate phosphatase activity
I634_RS02090	COG1609	Transcriptional regulator
I634_RS02095	COG0673	inositol 2-dehydrogenase activity
I634_RS02105	COG2211	Major facilitator Superfamily
I634_RS02130	COG1454	alcohol dehydrogenase
I634_RS02175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I634_RS02195	COG0089	rRNA binding
I634_RS02205	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I634_RS02215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I634_RS02230	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I634_RS02235	COG0438	transferase activity, transferring glycosyl groups
I634_RS02245	COG1519	Transferase
I634_RS02265	COG0840	transmembrane signaling receptor activity
I634_RS02280	COG0788	formyltetrahydrofolate deformylase activity
I634_RS02290	COG1643	Atp-dependent helicase
I634_RS02295	COG2951	lytic endotransglycosylase activity
I634_RS02300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I634_RS02310	COG2354	Protein conserved in bacteria
I634_RS02330	COG0004	ammonium transporteR
I634_RS02335	COG0405	Gamma-glutamyltransferase
I634_RS02340	COG2837	iron assimilation
I634_RS02355	COG0540	Belongs to the ATCase OTCase family
I634_RS02380	COG5002	protein histidine kinase activity
I634_RS02380	COG0784	Response regulator, receiver
I634_RS02380	COG2205	protein histidine kinase activity
I634_RS02405	COG1012	belongs to the aldehyde dehydrogenase family
I634_RS02415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I634_RS02430	COG0180	Tryptophanyl-tRNA synthetase
I634_RS02435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I634_RS02455	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I634_RS02465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I634_RS02500	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I634_RS02505	COG0281	malic enzyme
I634_RS02515	COG0625	glutathione transferase activity
I634_RS02525	COG0753	catalase activity
I634_RS02540	COG3300	MHYT domain
I634_RS02540	COG5001	Diguanylate cyclase
I634_RS02545	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I634_RS02545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I634_RS02555	COG0137	argininosuccinate synthase activity
I634_RS02575	COG1803	Methylglyoxal synthase
I634_RS02585	COG0745	RESPONSE REGULATOR receiver
I634_RS02590	COG2205	protein histidine kinase activity
I634_RS02595	COG2267	carboxylic ester hydrolase activity
I634_RS02600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I634_RS02610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I634_RS02620	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I634_RS02625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I634_RS02630	COG4942	peptidase
I634_RS02635	COG2861	carbohydrate metabolic process
I634_RS02660	COG1162	GTPase activity
I634_RS02665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I634_RS02690	COG0028	Belongs to the TPP enzyme family
I634_RS02710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I634_RS02715	COG0805	protein transport
I634_RS02725	COG0084	hydrolase, TatD family'
I634_RS02730	COG3706	GGDEF domain
I634_RS02730	COG5001	Diguanylate cyclase
I634_RS02730	COG4251	negative regulation of phosphorylation
I634_RS02730	COG2203	Gaf domain
I634_RS02740	COG0248	Ppx GppA phosphatase
I634_RS02745	COG0513	Belongs to the DEAD box helicase family
I634_RS02750	COG3118	belongs to the thioredoxin family
I634_RS02755	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I634_RS02760	COG1473	amidohydrolase
I634_RS02765	COG5002	protein histidine kinase activity
I634_RS02765	COG0784	Response regulator, receiver
I634_RS02770	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I634_RS02775	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I634_RS02780	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I634_RS02825	COG0783	Belongs to the Dps family
I634_RS02830	COG2133	pyrroloquinoline quinone binding
I634_RS02835	COG1506	peptidase
I634_RS02835	COG0823	Involved in the tonB-independent uptake of proteins
I634_RS02835	COG4946	Tricorn protease homolog
I634_RS02845	COG3118	belongs to the thioredoxin family
I634_RS02860	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I634_RS02870	COG1012	belongs to the aldehyde dehydrogenase family
I634_RS02890	COG1757	Na H antiporter
I634_RS02905	COG3876	Protein conserved in bacteria
I634_RS02910	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I634_RS02920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I634_RS02930	COG0346	lactoylglutathione lyase activity
I634_RS02955	COG2824	Alkylphosphonate utilization operon protein PhnA
I634_RS02960	COG0454	-acetyltransferase
I634_RS02985	COG3093	addiction module antidote protein HigA
I634_RS03000	COG2026	Addiction module toxin, RelE StbE family
I634_RS03040	COG1733	regulation of RNA biosynthetic process
I634_RS03080	COG3550	peptidyl-serine autophosphorylation
I634_RS03090	COG0183	Belongs to the thiolase family
I634_RS03095	COG1024	Enoyl-CoA hydratase
I634_RS03095	COG1250	3-hydroxyacyl-CoA dehydrogenase
I634_RS03105	COG0006	proline dipeptidase activity
I634_RS03115	COG0142	geranyltranstransferase activity
I634_RS03145	COG4942	peptidase
I634_RS03145	COG1388	LysM domain
I634_RS03150	COG1238	metal cluster binding
I634_RS03160	COG0585	pseudouridine synthase activity
I634_RS03165	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I634_RS03175	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I634_RS03185	COG0840	transmembrane signaling receptor activity
I634_RS03220	COG0494	nUDIX hydrolase
I634_RS03225	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I634_RS03230	COG0730	response to heat
I634_RS03235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I634_RS03240	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I634_RS03275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I634_RS03285	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I634_RS03295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I634_RS03295	COG1648	precorrin-2 dehydrogenase activity
I634_RS03300	COG0513	Belongs to the DEAD box helicase family
I634_RS03315	COG1538	Outer membrane efflux protein
I634_RS03320	COG0494	nUDIX hydrolase
I634_RS03330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I634_RS03335	COG3150	esterase
I634_RS03340	COG0187	DNA topoisomerase II activity
I634_RS03350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I634_RS03370	COG1509	lysine 2,3-aminomutase activity
I634_RS03375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I634_RS03380	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I634_RS03395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I634_RS03410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I634_RS03425	COG0271	Belongs to the BolA IbaG family
I634_RS03440	COG3707	response regulator
I634_RS03455	COG0659	secondary active sulfate transmembrane transporter activity
I634_RS03460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I634_RS03470	COG0243	molybdopterin cofactor binding
I634_RS03475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I634_RS03475	COG1648	precorrin-2 dehydrogenase activity
I634_RS03480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I634_RS03490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I634_RS03490	COG1116	anion transmembrane transporter activity
I634_RS03500	COG1116	anion transmembrane transporter activity
I634_RS03515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I634_RS03520	COG4206	TonB-dependent receptor
I634_RS03530	COG0348	domain, Protein
I634_RS03545	COG1960	acyl-CoA dehydrogenase activity
I634_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
I634_RS03560	COG4948	Mandelate Racemase Muconate Lactonizing
I634_RS03575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I634_RS03580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I634_RS03605	COG0358	DNA primase activity
I634_RS03625	COG1253	flavin adenine dinucleotide binding
I634_RS03635	COG1966	Carbon starvation protein
I634_RS03645	COG0657	acetylesterase activity
I634_RS03675	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I634_RS03680	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I634_RS03695	COG0537	adenosine 5'-monophosphoramidase activity
I634_RS03710	COG3135	benzoate transporter
I634_RS03715	COG1396	sequence-specific DNA binding
I634_RS03720	COG2974	May be involved in recombination
I634_RS03725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I634_RS03725	COG4191	Histidine kinase
I634_RS03730	COG0745	RESPONSE REGULATOR receiver
I634_RS03735	COG5002	protein histidine kinase activity
I634_RS03760	COG0811	peptide transport
I634_RS03765	COG0811	peptide transport
I634_RS03770	COG0848	biopolymer transport protein
I634_RS03775	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I634_RS03785	COG3437	response regulator, receiver
I634_RS03805	COG2133	pyrroloquinoline quinone binding
I634_RS03820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I634_RS03845	COG0527	aspartate kinase activity
I634_RS03855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I634_RS03860	COG2967	ApaG domain
I634_RS03870	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I634_RS03875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I634_RS03880	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I634_RS03885	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I634_RS03895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I634_RS03915	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I634_RS03930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I634_RS03935	COG3956	TIGRFAM MazG family protein
I634_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
I634_RS03970	COG0318	PFAM AMP-dependent synthetase and ligase
I634_RS03980	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I634_RS03990	COG0463	Glycosyl transferase, family 2
I634_RS04010	COG0642	Histidine kinase
I634_RS04030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I634_RS04035	COG0723	plastoquinol--plastocyanin reductase activity
I634_RS04040	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I634_RS04045	COG2857	Cytochrome c1
I634_RS04050	COG0625	glutathione transferase activity
I634_RS04055	COG2969	positive regulation of protein catabolic process
I634_RS04060	COG2239	Acts as a magnesium transporter
I634_RS04065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I634_RS04085	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I634_RS04090	COG1137	ATPase activity
I634_RS04095	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I634_RS04105	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I634_RS04120	COG1127	ABC transporter
I634_RS04125	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I634_RS04130	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I634_RS04135	COG2854	intermembrane phospholipid transfer
I634_RS04145	COG5007	Belongs to the BolA IbaG family
I634_RS04155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I634_RS04160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I634_RS04170	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I634_RS04205	COG4771	TonB-dependent receptor
I634_RS04210	COG0697	spore germination
I634_RS04220	COG2205	protein histidine kinase activity
I634_RS04220	COG0784	Response regulator, receiver
I634_RS04245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I634_RS04255	COG0126	phosphoglycerate kinase activity
I634_RS04260	COG3588	fructose-bisphosphate aldolase
I634_RS04270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I634_RS04280	COG1538	Outer membrane efflux protein
I634_RS04285	COG0823	Involved in the tonB-independent uptake of proteins
I634_RS04285	COG4946	Tricorn protease homolog
I634_RS04285	COG1506	peptidase
I634_RS04290	COG0248	Ppx GppA phosphatase
I634_RS04295	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I634_RS04305	COG0573	inorganic phosphate transmembrane transporter activity
I634_RS04315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I634_RS04325	COG0306	phosphate transporter
I634_RS04335	COG0583	DNA-binding transcription factor activity
I634_RS04345	COG1272	protein, Hemolysin III
I634_RS04355	COG1764	response to oxidative stress
I634_RS04370	COG1739	Uncharacterized protein family UPF0029
I634_RS04380	COG0420	3'-5' exonuclease activity
I634_RS04385	COG0419	ATPase involved in DNA repair
I634_RS04395	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I634_RS04420	COG2986	histidine ammonia-lyase
I634_RS04445	COG0488	(ABC) transporter
I634_RS04465	COG0668	transmembrane transport
I634_RS04540	COG1346	cytolysis
I634_RS04570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I634_RS04580	COG0513	Belongs to the DEAD box helicase family
I634_RS04590	COG3267	Type II secretory pathway component ExeA
I634_RS04590	COG3409	Peptidoglycan-binding domain 1 protein
I634_RS04605	COG0066	3-isopropylmalate dehydratase activity
I634_RS04615	COG0473	3-isopropylmalate dehydrogenase activity
I634_RS04620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I634_RS04640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I634_RS04655	COG4555	ABC transporter
I634_RS04660	COG1668	transmembrane transport
I634_RS04675	COG4133	protoheme IX ABC transporter activity
I634_RS04680	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I634_RS04685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I634_RS04690	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I634_RS04700	COG1138	Cytochrome C-type biogenesis protein
I634_RS04705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I634_RS04720	COG2853	Lipoprotein
I634_RS04725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I634_RS04765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I634_RS04780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I634_RS04785	COG1596	polysaccharide export
I634_RS04785	COG1555	photosystem II stabilization
I634_RS04790	COG0473	3-isopropylmalate dehydrogenase activity
I634_RS04805	COG1611	Belongs to the LOG family
I634_RS04815	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I634_RS04815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I634_RS04870	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I634_RS04875	COG0024	Methionine aminopeptidase
I634_RS04880	COG0052	Belongs to the universal ribosomal protein uS2 family
I634_RS04890	COG0528	UMP kinase activity
I634_RS04905	COG0575	Belongs to the CDS family
I634_RS04930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I634_RS04950	COG0587	DNA-directed DNA polymerase activity
I634_RS04955	COG0825	malonyl-CoA metabolic process
I634_RS04960	COG0037	tRNA processing
I634_RS04990	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I634_RS04990	COG0047	phosphoribosylformylglycinamidine synthase activity
I634_RS04995	COG2840	Smr protein MutS2
I634_RS05030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I634_RS05035	COG2197	response regulator
I634_RS05075	COG0835	chemotaxis
I634_RS05075	COG0784	Response regulator, receiver
I634_RS05080	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I634_RS05085	COG1815	bacterial-type flagellum-dependent cell motility
I634_RS05100	COG1749	Flagellar hook protein flgE
I634_RS05105	COG4787	bacterial-type flagellum-dependent cell motility
I634_RS05125	COG1705	Flagellar rod assembly protein muramidase FlgJ
I634_RS05125	COG3951	Flagellar rod assembly protein muramidase FlgJ
I634_RS05130	COG1256	bacterial-type flagellum assembly
I634_RS05160	COG1334	flagellar protein FlaG
I634_RS05165	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I634_RS05195	COG2089	acid synthase
I634_RS05200	COG3980	spore coat polysaccharide biosynthesis protein
I634_RS05205	COG1083	cytidylyl-transferase
I634_RS05210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I634_RS05215	COG1086	Polysaccharide biosynthesis protein
I634_RS05240	COG1677	Flagellar hook-basal body complex protein FliE
I634_RS05245	COG1766	The M ring may be actively involved in energy transduction
I634_RS05250	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I634_RS05300	COG1987	bacterial-type flagellum assembly
I634_RS05315	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I634_RS05340	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I634_RS05345	COG2198	Histidine kinase
I634_RS05345	COG0784	Response regulator, receiver
I634_RS05345	COG0643	Histidine kinase
I634_RS05355	COG1192	Involved in chromosome partitioning
I634_RS05365	COG0835	chemotaxis
I634_RS05380	COG1410	methionine synthase
I634_RS05380	COG0646	methionine synthase
I634_RS05385	COG0646	methionine synthase
I634_RS05385	COG1410	methionine synthase
I634_RS05395	COG3123	guanosine phosphorylase activity
I634_RS05400	COG0583	DNA-binding transcription factor activity
I634_RS05405	COG0583	DNA-binding transcription factor activity
I634_RS05415	COG0659	secondary active sulfate transmembrane transporter activity
I634_RS05430	COG3590	peptidase
I634_RS05440	COG2137	regulation of response to DNA damage stimulus
I634_RS05445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I634_RS05475	COG5016	pyruvate
I634_RS05475	COG0511	ligase activity, forming carbon-carbon bonds
I634_RS05480	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I634_RS05485	COG4172	Belongs to the ABC transporter superfamily
I634_RS05495	COG4171	peptide transport system, permease
I634_RS05500	COG4168	peptide transport system, permease
I634_RS05505	COG0747	negative chemotaxis
I634_RS05510	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I634_RS05515	COG1842	Phage shock protein A
I634_RS05545	COG0625	glutathione transferase activity
I634_RS05550	COG1522	sequence-specific DNA binding
I634_RS05615	COG0811	peptide transport
I634_RS05620	COG0811	peptide transport
I634_RS05625	COG0848	biopolymer transport protein
I634_RS05640	COG1444	tRNA N-acetyltransferase activity
I634_RS05680	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I634_RS05685	COG0250	Participates in transcription elongation, termination and antitermination
I634_RS05695	COG0456	acetyltransferase
I634_RS05705	COG0583	DNA-binding transcription factor activity
I634_RS05710	COG2814	Major facilitator Superfamily
I634_RS05720	COG0656	L-ascorbic acid biosynthetic process
I634_RS05735	COG1846	Transcriptional regulator
I634_RS05775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I634_RS05810	COG0543	2 iron, 2 sulfur cluster binding
I634_RS05810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I634_RS05825	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I634_RS05830	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I634_RS05835	COG0564	pseudouridine synthase activity
I634_RS05845	COG0612	Peptidase, M16
I634_RS05850	COG2918	glutathione biosynthetic process
I634_RS05870	COG2840	Smr protein MutS2
I634_RS05875	COG2890	protein-(glutamine-N5) methyltransferase activity
I634_RS05890	COG2719	SpoVR family
I634_RS05895	COG2718	Belongs to the UPF0229 family
I634_RS05900	COG2766	serine protein kinase
I634_RS05905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I634_RS05910	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I634_RS05915	COG4771	TonB-dependent receptor
I634_RS05940	COG0450	alkyl hydroperoxide reductase
I634_RS05950	COG2885	chlorophyll binding
I634_RS05955	COG0584	glycerophosphoryl diester phosphodiesterase
I634_RS05960	COG0346	lactoylglutathione lyase activity
I634_RS05965	COG1278	Cold shock
I634_RS05980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I634_RS05985	COG4660	Part of a membrane complex involved in electron transport
I634_RS05990	COG4659	FMN binding
I634_RS05995	COG4658	electron transport chain
I634_RS06000	COG4656	Part of a membrane complex involved in electron transport
I634_RS06005	COG2878	Part of a membrane complex involved in electron transport
I634_RS06010	COG4657	Part of a membrane complex involved in electron transport
I634_RS06025	COG0534	Mate efflux family protein
I634_RS06030	COG0556	nucleotide-excision repair
I634_RS06045	COG0602	queuosine metabolic process
I634_RS06055	COG0367	asparagine synthase
I634_RS06080	COG0471	metal ion transport
I634_RS06080	COG3273	potassium ion transport
I634_RS06095	COG0529	Catalyzes the synthesis of activated sulfate
I634_RS06100	COG0175	sulfate reduction
I634_RS06105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I634_RS06110	COG3706	GGDEF domain
I634_RS06135	COG2304	oxidoreductase activity
I634_RS06155	COG0714	Associated with various cellular activities
I634_RS06165	COG1250	3-hydroxyacyl-CoA dehydrogenase
I634_RS06165	COG1024	Enoyl-CoA hydratase
I634_RS06185	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I634_RS06205	COG0402	S-adenosylhomocysteine deaminase activity
I634_RS06210	COG1228	amidohydrolase
I634_RS06215	COG2188	Transcriptional regulator
I634_RS06220	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I634_RS06230	COG3314	Sporulation integral membrane protein YlbJ
I634_RS06260	COG1025	Belongs to the peptidase M16 family
I634_RS06265	COG2062	phosphohistidine phosphatase, SixA
I634_RS06275	COG4536	flavin adenine dinucleotide binding
I634_RS06280	COG4137	Cytochrome C assembly protein
I634_RS06285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I634_RS06340	COG1132	(ABC) transporter
I634_RS06355	COG0228	four-way junction DNA binding
I634_RS06360	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I634_RS06365	COG0336	Belongs to the RNA methyltransferase TrmD family
I634_RS06370	COG0335	large ribosomal subunit rRNA binding
I634_RS06375	COG2860	membrane
I634_RS06385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I634_RS06390	COG1605	Chorismate mutase
I634_RS06390	COG0287	Prephenate dehydrogenase
I634_RS06395	COG1605	Chorismate mutase
I634_RS06395	COG0077	Prephenate dehydratase
I634_RS06400	COG0745	RESPONSE REGULATOR receiver
I634_RS06405	COG0023	Translation Initiation Factor
I634_RS06435	COG2205	protein histidine kinase activity
I634_RS06445	COG2204	response regulator
I634_RS06465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I634_RS06470	COG0494	nUDIX hydrolase
I634_RS06475	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I634_RS06480	COG0632	four-way junction helicase activity
I634_RS06485	COG2255	four-way junction helicase activity
I634_RS06490	COG0824	Thioesterase
I634_RS06495	COG0811	peptide transport
I634_RS06510	COG0823	Involved in the tonB-independent uptake of proteins
I634_RS06515	COG2885	chlorophyll binding
I634_RS06520	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I634_RS06540	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I634_RS06555	COG4667	esterase of the alpha-beta hydrolase superfamily
I634_RS06560	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I634_RS06575	COG1028	Short-chain dehydrogenase reductase Sdr
I634_RS06580	COG3038	cytochrome b561
I634_RS06605	COG1451	nucleotide metabolic process
I634_RS06615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I634_RS06625	COG1309	transcriptional regulator
I634_RS06630	COG4774	siderophore transport
I634_RS06650	COG3706	GGDEF domain
I634_RS06660	COG3008	intermembrane lipid transfer
I634_RS06660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I634_RS06665	COG2995	paraquat-inducible protein a
I634_RS06680	COG0017	Asparaginyl-tRNA synthetase
I634_RS06695	COG0189	ligase activity
I634_RS06725	COG0156	8-amino-7-oxononanoate synthase activity
I634_RS06730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I634_RS06740	COG3340	Belongs to the peptidase S51 family
I634_RS06745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I634_RS06750	COG4139	cobalamin transport
I634_RS06755	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I634_RS06760	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I634_RS06775	COG5265	(ABC) transporter
I634_RS06780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I634_RS06790	COG0745	RESPONSE REGULATOR receiver
I634_RS06815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I634_RS06855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I634_RS06870	COG2755	lipolytic protein G-D-S-L family
I634_RS06875	COG4181	ATPase activity
I634_RS06880	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I634_RS06885	COG1090	epimerase
I634_RS06890	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I634_RS06895	COG0628	permease
I634_RS06920	COG2350	Protein conserved in bacteria
I634_RS06925	COG0159	tryptophan synthase activity
I634_RS06935	COG0135	phosphoribosylanthranilate isomerase activity
I634_RS06935	COG0134	indole-3-glycerol-phosphate synthase activity
I634_RS06940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I634_RS06950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I634_RS06955	COG0613	PHP domain protein
I634_RS06960	COG0009	L-threonylcarbamoyladenylate synthase
I634_RS06970	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I634_RS06980	COG0656	L-ascorbic acid biosynthetic process
I634_RS06985	COG0110	maltose O-acetyltransferase activity
I634_RS06995	COG2733	membrane
I634_RS07000	COG0500	methyltransferase
I634_RS07005	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I634_RS07010	COG0497	DNA recombination
I634_RS07015	COG0783	Belongs to the Dps family
I634_RS07020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I634_RS07025	COG1454	alcohol dehydrogenase
I634_RS07030	COG1028	Short-chain dehydrogenase reductase Sdr
I634_RS07040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I634_RS07045	COG2610	gluconate transmembrane transporter activity
I634_RS07060	COG0784	Response regulator, receiver
I634_RS07060	COG2198	Histidine kinase
I634_RS07060	COG2205	protein histidine kinase activity
I634_RS07065	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I634_RS07075	COG0484	heat shock protein binding
I634_RS07080	COG3909	cytochrome
I634_RS07085	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I634_RS07100	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I634_RS07110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I634_RS07115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I634_RS07140	COG0857	belongs to the CobB CobQ family
I634_RS07140	COG0280	phosphate acetyltransferase
I634_RS07155	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I634_RS07160	COG4535	Mg2 and Co2 transporter CorC
I634_RS07170	COG1702	phosphate starvation-inducible protein PhoH
I634_RS07180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I634_RS07205	COG1607	acyl-coa hydrolase
I634_RS07210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I634_RS07220	COG1115	amino acid carrier protein
I634_RS07235	COG0012	GTP binding
I634_RS07250	COG1064	alcohol dehydrogenase
I634_RS07265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I634_RS07290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I634_RS07295	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I634_RS07300	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I634_RS07310	COG2890	protein-(glutamine-N5) methyltransferase activity
I634_RS07315	COG3437	response regulator, receiver
I634_RS07315	COG0784	Response regulator, receiver
I634_RS07325	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I634_RS07335	COG0583	DNA-binding transcription factor activity
I634_RS07345	COG2363	Small membrane protein
I634_RS07360	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I634_RS07365	COG0515	serine threonine protein kinase
I634_RS07370	COG2116	formate transmembrane transporter activity
I634_RS07385	COG0714	Associated with various cellular activities
I634_RS07390	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I634_RS07395	COG0033	Phosphoglucomutase
I634_RS07400	COG0058	SHG alpha-glucan phosphorylase activity
I634_RS07410	COG2988	succinylglutamate desuccinylase activity
I634_RS07445	COG1393	Belongs to the ArsC family
I634_RS07470	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I634_RS07530	COG0475	glutathione-regulated potassium exporter activity
I634_RS07530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I634_RS07545	COG1733	regulation of RNA biosynthetic process
I634_RS07550	COG3447	MASE1 domain protein
I634_RS07550	COG5001	Diguanylate cyclase
I634_RS07550	COG5002	protein histidine kinase activity
I634_RS07560	COG0402	S-adenosylhomocysteine deaminase activity
I634_RS07565	COG2351	hydroxyisourate hydrolase activity
I634_RS07580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I634_RS07595	COG1309	transcriptional regulator
I634_RS07610	COG2252	PERMEase
I634_RS07615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I634_RS07630	COG5001	Diguanylate cyclase
I634_RS07630	COG4251	negative regulation of phosphorylation
I634_RS07630	COG3706	GGDEF domain
I634_RS07630	COG2203	Gaf domain
I634_RS07635	COG2203	Gaf domain
I634_RS07635	COG3706	GGDEF domain
I634_RS07635	COG4251	negative regulation of phosphorylation
I634_RS07635	COG5001	Diguanylate cyclase
I634_RS07640	COG0784	Response regulator, receiver
I634_RS07640	COG2205	protein histidine kinase activity
I634_RS07655	COG2233	PERMEase
I634_RS07670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I634_RS07675	COG0730	response to heat
I634_RS07715	COG1028	Short-chain dehydrogenase reductase Sdr
I634_RS07720	COG3001	Fructosamine kinase
I634_RS07730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I634_RS07750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I634_RS07760	COG1596	polysaccharide export
I634_RS07765	COG0489	protein tyrosine kinase activity
I634_RS07770	COG4464	protein tyrosine phosphatase activity
I634_RS07795	COG3300	MHYT domain
I634_RS07795	COG5001	Diguanylate cyclase
I634_RS07805	COG0297	glycogen (starch) synthase activity
I634_RS07820	COG1215	transferase activity, transferring glycosyl groups
I634_RS07825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I634_RS07830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I634_RS07855	COG0297	glycogen (starch) synthase activity
I634_RS07870	COG0072	phenylalanine-tRNA ligase activity
I634_RS07870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I634_RS07885	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I634_RS07895	COG1472	Belongs to the glycosyl hydrolase 3 family
I634_RS07900	COG2096	Adenosyltransferase
I634_RS07910	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I634_RS07920	COG4591	ABC-type transport system involved in lipoprotein release permease component
I634_RS07945	COG0708	Exodeoxyribonuclease III
I634_RS07980	COG2814	Major facilitator Superfamily
I634_RS08015	COG4770	biotin carboxylase activity
I634_RS08020	COG1024	Enoyl-CoA hydratase
I634_RS08025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I634_RS08030	COG1960	acyl-CoA dehydrogenase activity
I634_RS08035	COG0789	Transcriptional regulator
I634_RS08040	COG0183	Belongs to the thiolase family
I634_RS08055	COG3706	GGDEF domain
I634_RS08065	COG2925	Exonuclease
I634_RS08115	COG1643	Atp-dependent helicase
I634_RS08135	COG3321	synthase
I634_RS08135	COG0604	alcohol dehydrogenase
I634_RS08140	COG0328	RNA-DNA hybrid ribonuclease activity
I634_RS08145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I634_RS08175	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I634_RS08180	COG1136	(ABC) transporter
I634_RS08185	COG4591	ABC-type transport system involved in lipoprotein release permease component
I634_RS08190	COG1301	dicarboxylic acid transport
I634_RS08200	COG3724	N-succinylarginine dihydrolase activity
I634_RS08205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I634_RS08220	COG0746	molybdenum cofactor guanylyltransferase activity
I634_RS08225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I634_RS08230	COG0243	molybdopterin cofactor binding
I634_RS08235	COG2153	protein acetylation
I634_RS08250	COG1530	ribonuclease E activity
I634_RS08265	COG0424	maF-like protein
I634_RS08270	COG1399	metal-binding, possibly nucleic acid-binding protein
I634_RS08280	COG0416	fatty acid biosynthetic process
I634_RS08285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I634_RS08290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I634_RS08300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I634_RS08305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I634_RS08315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I634_RS08330	COG0084	hydrolase, TatD family'
I634_RS08340	COG0702	epimerase
I634_RS08345	COG3706	GGDEF domain
I634_RS08365	COG1028	Short-chain dehydrogenase reductase Sdr
I634_RS08370	COG0596	Alpha beta hydrolase
I634_RS08380	COG0183	Belongs to the thiolase family
I634_RS08385	COG1960	acyl-CoA dehydrogenase activity
I634_RS08405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I634_RS08415	COG0246	Mannitol dehydrogenase
I634_RS08435	COG0668	transmembrane transport
I634_RS08440	COG4771	TonB-dependent receptor
I634_RS08455	COG2205	protein histidine kinase activity
I634_RS08455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I634_RS08460	COG3437	response regulator, receiver
I634_RS08470	COG0195	Participates in both transcription termination and antitermination
I634_RS08485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I634_RS08500	COG1187	pseudouridine synthase activity
I634_RS08510	COG3153	acetyltransferase
I634_RS08510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I634_RS08580	COG1032	radical SAM domain protein
I634_RS08595	COG4771	TonB-dependent receptor
I634_RS08600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I634_RS08610	COG4134	Bacterial extracellular solute-binding protein
I634_RS08620	COG4136	ATPase activity
I634_RS08625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I634_RS08645	COG3706	GGDEF domain
I634_RS08645	COG4251	negative regulation of phosphorylation
I634_RS08645	COG5001	Diguanylate cyclase
I634_RS08645	COG2203	Gaf domain
I634_RS08675	COG1902	pentaerythritol trinitrate reductase activity
I634_RS08685	COG2867	negative regulation of translational initiation
I634_RS08690	COG2914	Belongs to the UPF0125 (RnfH) family
I634_RS08700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I634_RS08705	COG4771	TonB-dependent receptor
I634_RS08710	COG0457	Tetratricopeptide repeat
I634_RS08725	COG0574	Belongs to the PEP-utilizing enzyme family
I634_RS08725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I634_RS08760	COG2850	peptidyl-arginine hydroxylation
I634_RS08770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I634_RS08775	COG2915	High frequency lysogenization protein hflD homolog
I634_RS08780	COG0482	sulfurtransferase activity
I634_RS08785	COG1187	pseudouridine synthase activity
I634_RS08795	COG1278	Cold shock
I634_RS08800	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I634_RS08805	COG0542	response to heat
I634_RS08810	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I634_RS08815	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I634_RS08820	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I634_RS08825	COG0492	ferredoxin-NADP+ reductase activity
I634_RS08835	COG3091	SprT-like family
I634_RS08840	COG0616	signal peptide processing
I634_RS08855	COG0778	Nitroreductase
I634_RS08865	COG0252	asparaginase activity
I634_RS08870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I634_RS08875	COG0321	lipoyl(octanoyl) transferase activity
I634_RS08880	COG2921	Belongs to the UPF0250 family
I634_RS08885	COG1686	Belongs to the peptidase S11 family
I634_RS08890	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I634_RS08895	COG0772	Belongs to the SEDS family
I634_RS08900	COG0768	penicillin binding
I634_RS08905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I634_RS08910	COG0799	negative regulation of ribosome biogenesis
I634_RS08915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I634_RS08920	COG1466	dna polymerase III delta subunit
I634_RS08925	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I634_RS08930	COG0495	leucyl-tRNA aminoacylation
I634_RS08945	COG1067	ATP-dependent peptidase activity
I634_RS08950	COG0596	Alpha beta hydrolase
I634_RS08965	COG1534	Rna-binding protein
I634_RS08970	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I634_RS08975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I634_RS08980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I634_RS08985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I634_RS08990	COG0149	triose-phosphate isomerase activity
I634_RS08995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I634_RS09005	COG5001	Diguanylate cyclase
I634_RS09005	COG3300	MHYT domain
I634_RS09025	COG1803	Methylglyoxal synthase
I634_RS09025	COG1597	lipid kinase activity
I634_RS09035	COG1028	Short-chain dehydrogenase reductase Sdr
I634_RS09040	COG0561	phosphatase activity
I634_RS09055	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I634_RS09060	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I634_RS09065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I634_RS09080	COG1185	polyribonucleotide nucleotidyltransferase activity
I634_RS09200	COG2963	transposase activity
I634_RS09205	COG2755	lipolytic protein G-D-S-L family
I634_RS09205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I634_RS09335	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I634_RS09340	COG1196	nuclear chromosome segregation
I634_RS09350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I634_RS09365	COG1132	(ABC) transporter
I634_RS09370	COG1663	tetraacyldisaccharide 4'-kinase activity
I634_RS09405	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I634_RS09410	COG0435	Glutathione S-transferase
I634_RS09415	COG1741	Belongs to the pirin family
I634_RS09420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I634_RS09430	COG0372	Belongs to the citrate synthase family
I634_RS09440	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I634_RS09445	COG1053	succinate dehydrogenase
I634_RS09450	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I634_RS09455	COG0567	Dehydrogenase, E1 component
I634_RS09460	COG0508	dehydrogenase complex catalyzes the overall conversion of
I634_RS09500	COG4667	esterase of the alpha-beta hydrolase superfamily
I634_RS09520	COG0366	Alpha amylase catalytic
I634_RS09545	COG1028	Short-chain dehydrogenase reductase Sdr
I634_RS09550	COG2267	carboxylic ester hydrolase activity
I634_RS09560	COG0616	signal peptide processing
I634_RS09580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I634_RS09585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I634_RS09590	COG0386	Belongs to the glutathione peroxidase family
I634_RS09595	COG2084	Dehydrogenase
I634_RS09605	COG1960	acyl-CoA dehydrogenase activity
I634_RS09610	COG1024	Enoyl-CoA hydratase
I634_RS09615	COG2226	methyltransferase
I634_RS09625	COG3083	sulfuric ester hydrolase activity
I634_RS09630	COG3082	Protein of unknown function (DUF1414)
I634_RS09635	COG3081	Nucleoid-associated protein
I634_RS09665	COG3275	phosphorelay sensor kinase activity
I634_RS09670	COG3279	Response regulator of the LytR AlgR family
I634_RS09675	COG0205	6-phosphofructokinase activity
I634_RS09720	COG2201	protein-glutamate methylesterase activity
I634_RS09745	COG0675	Transposase, IS605 OrfB family
I634_RS09790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I634_RS09805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I634_RS09805	COG2205	protein histidine kinase activity
I634_RS09815	COG1054	Belongs to the UPF0176 family
I634_RS09825	COG0513	Belongs to the DEAD box helicase family
I634_RS09835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I634_RS09840	COG0583	DNA-binding transcription factor activity
I634_RS09860	COG1760	l-serine dehydratase
I634_RS09885	COG1322	Protein conserved in bacteria
I634_RS09890	COG1404	Belongs to the peptidase S8 family
I634_RS09895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I634_RS09900	COG0022	dehydrogenase e1 component
I634_RS09910	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I634_RS09915	COG0515	serine threonine protein kinase
I634_RS09920	COG1946	Acyl-CoA thioesterase
I634_RS09930	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I634_RS09940	COG1956	GAF domain-containing protein
I634_RS09955	COG0793	Belongs to the peptidase S41A family
I634_RS09960	COG0733	neurotransmitter:sodium symporter activity
I634_RS09965	COG1757	Na H antiporter
I634_RS09970	COG0308	aminopeptidase N
I634_RS10000	COG2902	Dehydrogenase
I634_RS10005	COG0167	dihydroorotate dehydrogenase activity
I634_RS10020	COG0488	(ABC) transporter
I634_RS10030	COG3130	regulation of translation
I634_RS10035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I634_RS10045	COG0415	Belongs to the DNA photolyase family
I634_RS10065	COG2059	Chromate
I634_RS10080	COG0415	Belongs to the DNA photolyase family
I634_RS10095	COG0415	Belongs to the DNA photolyase family
I634_RS10100	COG3046	protein related to deoxyribodipyrimidine photolyase
I634_RS10110	COG4974	Belongs to the 'phage' integrase family
I634_RS10120	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I634_RS10125	COG0589	response to stress
I634_RS10135	COG0069	glutamate synthase activity
I634_RS10150	COG2193	ferroxidase activity
I634_RS10160	COG3278	Belongs to the heme-copper respiratory oxidase family
I634_RS10175	COG2010	Cytochrome c
I634_RS10200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I634_RS10205	COG0589	response to stress
I634_RS10210	COG0037	tRNA processing
I634_RS10215	COG1752	Esterase of the alpha-beta hydrolase superfamily
I634_RS10235	COG1280	lysine exporter protein (LysE YggA)
I634_RS10245	COG2897	thiosulfate sulfurtransferase activity
I634_RS10250	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I634_RS10255	COG3148	PFAM DTW domain containing protein
I634_RS10330	COG0582	viral genome integration into host DNA
I634_RS10360	COG0322	excinuclease ABC activity
I634_RS10365	COG2197	response regulator
I634_RS10370	COG0436	Aminotransferase
I634_RS10385	COG2259	Doxx family
I634_RS10390	COG0583	DNA-binding transcription factor activity
I634_RS10400	COG0670	Belongs to the BI1 family
I634_RS10405	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I634_RS10420	COG2920	part of a sulfur-relay system
I634_RS10455	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I634_RS10465	COG0531	amino acid
I634_RS10465	COG1674	ftsk spoiiie
I634_RS10475	COG0686	Belongs to the AlaDH PNT family
I634_RS10480	COG0284	orotidine-5'-phosphate decarboxylase activity
I634_RS10485	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I634_RS10500	COG0776	regulation of translation
I634_RS10505	COG0539	negative regulation of cytoplasmic translation
I634_RS10510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I634_RS10515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I634_RS10520	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I634_RS10530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I634_RS10535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I634_RS10540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I634_RS10545	COG0633	Ferredoxin
I634_RS10580	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I634_RS10585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I634_RS10595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I634_RS10605	COG4783	chaperone-mediated protein folding
I634_RS10615	COG1393	Belongs to the ArsC family
I634_RS10630	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I634_RS10645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I634_RS10655	COG1960	acyl-CoA dehydrogenase activity
I634_RS10680	COG0572	uridine kinase
I634_RS10685	COG3769	mannosylglycerate metabolic process
I634_RS10690	COG1215	transferase activity, transferring glycosyl groups
I634_RS10695	COG0366	Alpha amylase catalytic
I634_RS10705	COG0303	'Molybdopterin
I634_RS10710	COG0534	Mate efflux family protein
I634_RS10725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I634_RS10730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I634_RS10780	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I634_RS10810	COG0405	Gamma-glutamyltransferase
I634_RS10815	COG1024	Enoyl-CoA hydratase
I634_RS10860	COG1448	Aminotransferase
I634_RS10880	COG1671	Belongs to the UPF0178 family
I634_RS10885	COG1028	Short-chain dehydrogenase reductase Sdr
I634_RS10890	COG1028	Short-chain dehydrogenase reductase Sdr
I634_RS10895	COG1960	acyl-CoA dehydrogenase activity
I634_RS10900	COG2207	Transcriptional regulator
I634_RS10900	COG0662	Cupin 2, conserved barrel domain protein
I634_RS10905	COG4771	TonB-dependent receptor
I634_RS10915	COG1505	serine-type exopeptidase activity
I634_RS10925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I634_RS10955	COG0596	Alpha beta hydrolase
I634_RS10965	COG0716	FMN binding
I634_RS10975	COG0735	belongs to the Fur family
I634_RS10985	COG1984	allophanate hydrolase subunit 2
I634_RS10990	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I634_RS10995	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I634_RS11000	COG2996	Protein conserved in bacteria
I634_RS11005	COG1765	OsmC-like protein
I634_RS11010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I634_RS11020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I634_RS11035	COG0436	Aminotransferase
I634_RS11040	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I634_RS11045	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I634_RS11055	COG2010	Cytochrome c
I634_RS11055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I634_RS11060	COG2080	2 iron, 2 sulfur cluster binding
I634_RS11085	COG1073	alpha beta
I634_RS11090	COG2207	Transcriptional regulator
I634_RS11100	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I634_RS11105	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I634_RS11130	COG3012	SEC-C Motif Domain Protein
I634_RS11135	COG0604	alcohol dehydrogenase
I634_RS11145	COG1960	acyl-CoA dehydrogenase activity
I634_RS11155	COG4771	TonB-dependent receptor
I634_RS11180	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I634_RS11200	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I634_RS11210	COG0521	Mo-molybdopterin cofactor biosynthetic process
I634_RS11225	COG2161	toxin-antitoxin pair type II binding
I634_RS11230	COG4115	mRNA cleavage
I634_RS11245	COG0436	Aminotransferase
I634_RS11250	COG3268	Saccharopine dehydrogenase
I634_RS11255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I634_RS11270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I634_RS11275	COG4206	TonB-dependent receptor
I634_RS11285	COG5006	permease, DMT superfamily
I634_RS11300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I634_RS11305	COG1074	ATP-dependent DNA helicase activity
I634_RS11310	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I634_RS11325	COG1022	Amp-dependent synthetase and ligase
I634_RS11330	COG4251	negative regulation of phosphorylation
I634_RS11330	COG3706	GGDEF domain
I634_RS11330	COG2203	Gaf domain
I634_RS11330	COG5001	Diguanylate cyclase
I634_RS11350	COG0583	DNA-binding transcription factor activity
I634_RS11365	COG0640	Transcriptional regulator
I634_RS11385	COG2204	response regulator
I634_RS11395	COG4251	negative regulation of phosphorylation
I634_RS11400	COG0784	Response regulator, receiver
I634_RS11405	COG0784	Response regulator, receiver
I634_RS11405	COG2205	protein histidine kinase activity
I634_RS11430	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I634_RS11455	COG3139	Protein of unknown function (DUF1315)
I634_RS11470	COG1115	amino acid carrier protein
I634_RS11475	COG2866	Carboxypeptidase
I634_RS11495	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I634_RS11505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I634_RS11510	COG1640	4-alpha-glucanotransferase
I634_RS11515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I634_RS11520	COG0676	glucose-6-phosphate 1-epimerase activity
I634_RS11525	COG0800	Aldolase
I634_RS11535	COG0129	dihydroxy-acid dehydratase activity
I634_RS11545	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I634_RS11550	COG1737	Transcriptional regulator
I634_RS11555	COG0469	pyruvate kinase activity
I634_RS11560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I634_RS11580	COG2823	Periplasmic or secreted lipoprotein
I634_RS11610	COG3665	Urea carboxylase-associated protein
I634_RS11630	COG1028	Short-chain dehydrogenase reductase Sdr
I634_RS11635	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I634_RS11645	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I634_RS11660	COG2721	sulfolactate sulfo-lyase activity
I634_RS11665	COG1904	glucuronate isomerase
I634_RS11670	COG0246	Mannitol dehydrogenase
I634_RS11675	COG0800	Aldolase
I634_RS11680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I634_RS11685	COG2755	lipolytic protein G-D-S-L family
I634_RS11695	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I634_RS11705	COG4677	pectinesterase activity
I634_RS11725	COG2356	endonuclease I
I634_RS11730	COG0840	transmembrane signaling receptor activity
I634_RS11745	COG0583	DNA-binding transcription factor activity
I634_RS11750	COG1979	alcohol dehydrogenase
I634_RS11755	COG5001	Diguanylate cyclase
I634_RS11765	COG0784	Response regulator, receiver
I634_RS11765	COG3437	response regulator, receiver
I634_RS11785	COG0471	metal ion transport
I634_RS11795	COG0489	protein tyrosine kinase activity
I634_RS11800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I634_RS11800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I634_RS11805	COG0668	transmembrane transport
I634_RS11810	COG2226	methyltransferase
I634_RS11815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I634_RS11820	COG0741	lytic transglycosylase activity
I634_RS11820	COG1388	LysM domain
I634_RS11845	COG0215	cysteine-tRNA ligase activity
I634_RS11850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I634_RS11860	COG1785	Belongs to the alkaline phosphatase family
I634_RS11865	COG1785	Belongs to the alkaline phosphatase family
I634_RS11880	COG2268	Band 7 protein
I634_RS11885	COG0583	DNA-binding transcription factor activity
I634_RS11890	COG1028	Short-chain dehydrogenase reductase Sdr
I634_RS11900	COG1733	regulation of RNA biosynthetic process
I634_RS11905	COG0604	alcohol dehydrogenase
I634_RS11910	COG0753	catalase activity
I634_RS11915	COG0604	alcohol dehydrogenase
I634_RS11945	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I634_RS11950	COG1286	toxin biosynthetic process
I634_RS11955	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I634_RS11960	COG0285	dihydrofolate synthase activity
I634_RS11985	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I634_RS11990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I634_RS12010	COG3609	addiction module antidote protein, CC2985 family
I634_RS12015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I634_RS12020	COG0318	PFAM AMP-dependent synthetase and ligase
I634_RS12030	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I634_RS12030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I634_RS12065	COG0789	Transcriptional regulator
I634_RS12070	COG0604	alcohol dehydrogenase
I634_RS12085	COG1119	ATPase activity
I634_RS12090	COG2031	fatty acid transporter
I634_RS12095	COG0784	Response regulator, receiver
I634_RS12095	COG2205	protein histidine kinase activity
I634_RS12095	COG5002	protein histidine kinase activity
I634_RS12105	COG0612	Peptidase, M16
I634_RS12120	COG3101	peptidyl-lysine hydroxylation
I634_RS12145	COG0446	pyridine nucleotide-disulphide oxidoreductase
I634_RS12145	COG1902	pentaerythritol trinitrate reductase activity
I634_RS12180	COG4399	Belongs to the UPF0754 family
I634_RS12205	COG1770	oligopeptidase
I634_RS12210	COG2186	Transcriptional regulator
I634_RS12220	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I634_RS12225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I634_RS12235	COG2983	Belongs to the UPF0260 family
I634_RS12240	COG0179	Fumarylacetoacetate (FAA) hydrolase
I634_RS12255	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I634_RS12260	COG0318	PFAM AMP-dependent synthetase and ligase
I634_RS12265	COG2267	carboxylic ester hydrolase activity
I634_RS12280	COG1214	PFAM Peptidase M22, glycoprotease
I634_RS12285	COG1199	ATP-dependent helicase activity
I634_RS12335	COG4771	TonB-dependent receptor
I634_RS12345	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I634_RS12350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I634_RS12355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I634_RS12360	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I634_RS12360	COG0131	Imidazoleglycerol-phosphate dehydratase
I634_RS12365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I634_RS12395	COG2116	formate transmembrane transporter activity
I634_RS12400	COG0612	Peptidase, M16
I634_RS12425	COG0326	Molecular chaperone. Has ATPase activity
I634_RS12430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I634_RS12460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I634_RS12470	COG3220	belongs to the UPF0276 family
I634_RS12480	COG0577	efflux transmembrane transporter activity
I634_RS12480	COG1136	(ABC) transporter
I634_RS12490	COG3706	GGDEF domain
I634_RS12490	COG5001	Diguanylate cyclase
I634_RS12490	COG2203	Gaf domain
I634_RS12490	COG4251	negative regulation of phosphorylation
I634_RS12510	COG1183	phosphatidylcholine synthase activity
I634_RS12525	COG0457	Tetratricopeptide repeat
I634_RS12530	COG0277	FAD linked oxidase domain protein
I634_RS12535	COG0542	response to heat
I634_RS12560	COG1595	DNA-templated transcription, initiation
I634_RS12575	COG4221	oxidoreductase activity
I634_RS12590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I634_RS12600	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I634_RS12610	COG0142	geranyltranstransferase activity
I634_RS12620	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I634_RS12625	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I634_RS12635	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I634_RS12650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I634_RS12650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I634_RS12665	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I634_RS12670	COG0488	(ABC) transporter
I634_RS12680	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I634_RS12690	COG0560	Phosphoserine phosphatase
I634_RS12700	COG0084	hydrolase, TatD family'
I634_RS12710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I634_RS12715	COG0571	ribonuclease III activity
I634_RS12745	COG1595	DNA-templated transcription, initiation
I634_RS12750	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I634_RS12765	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I634_RS12845	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I634_RS12850	COG1047	Peptidyl-prolyl cis-trans
I634_RS12860	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I634_RS12865	COG0196	riboflavin kinase activity
I634_RS12870	COG0728	peptidoglycan biosynthetic process
I634_RS12875	COG0268	Binds directly to 16S ribosomal RNA
I634_RS12895	COG0385	Bile acid
I634_RS12925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I634_RS12930	COG0776	regulation of translation
I634_RS12940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I634_RS12945	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I634_RS12950	COG0740	serine-type endopeptidase activity
I634_RS12955	COG0544	peptidyl-prolyl cis-trans isomerase activity
I634_RS13015	COG1720	tRNA m6t6A37 methyltransferase activity
I634_RS13025	COG1234	tRNA 3'-trailer cleavage
I634_RS13035	COG0123	including yeast histone deacetylase and acetoin utilization protein
I634_RS13060	COG0517	IMP dehydrogenase activity
I634_RS13060	COG0516	GMP reductase activity
I634_RS13065	COG1570	exodeoxyribonuclease VII activity
I634_RS13085	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I634_RS13090	COG2976	Protein conserved in bacteria
I634_RS13115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I634_RS13125	COG2166	iron-sulfur cluster assembly
I634_RS13140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I634_RS13145	COG0719	Fe-S assembly protein
I634_RS13150	COG0396	ATPase activity
I634_RS13155	COG0719	Fe-S assembly protein
I634_RS13160	COG1104	cysteine desulfurase activity
I634_RS13165	COG1959	2 iron, 2 sulfur cluster binding
I634_RS13170	COG2072	flavoprotein involved in K transport
I634_RS13175	COG1045	serine acetyltransferase
I634_RS13180	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I634_RS13185	COG0483	inositol monophosphate 1-phosphatase activity
I634_RS13200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I634_RS13205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I634_RS13210	COG1862	Preprotein translocase
I634_RS13215	COG0343	queuine tRNA-ribosyltransferase activity
I634_RS13235	COG1842	Phage shock protein A
I634_RS13240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I634_RS13260	COG0754	glutathionylspermidine amidase activity
I634_RS13290	COG2066	Belongs to the glutaminase family
I634_RS13295	COG1785	Belongs to the alkaline phosphatase family
I634_RS13300	COG0745	RESPONSE REGULATOR receiver
I634_RS13385	COG0438	transferase activity, transferring glycosyl groups
I634_RS13400	COG0367	asparagine synthase
I634_RS13405	COG0438	transferase activity, transferring glycosyl groups
I634_RS13425	COG0110	maltose O-acetyltransferase activity
I634_RS13430	COG2244	polysaccharide biosynthetic process
I634_RS13455	COG2327	Polysaccharide pyruvyl transferase
I634_RS13495	COG0489	protein tyrosine kinase activity
I634_RS13505	COG3267	Type II secretory pathway component ExeA
I634_RS13505	COG3409	Peptidoglycan-binding domain 1 protein
I634_RS13510	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I634_RS13510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I634_RS13540	COG1560	Kdo2-lipid A biosynthetic process
I634_RS13555	COG1960	acyl-CoA dehydrogenase activity
I634_RS13570	COG5001	Diguanylate cyclase
I634_RS13570	COG3300	MHYT domain
I634_RS13575	COG1435	thymidine kinase activity
I634_RS13585	COG1609	Transcriptional regulator
I634_RS13590	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I634_RS13625	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I634_RS13630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I634_RS13635	COG1250	3-hydroxyacyl-CoA dehydrogenase
I634_RS13635	COG1024	Enoyl-CoA hydratase
I634_RS13650	COG1012	belongs to the aldehyde dehydrogenase family
I634_RS13670	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I634_RS13675	COG0789	Transcriptional regulator
I634_RS13705	COG1960	acyl-CoA dehydrogenase activity
I634_RS13730	COG0745	RESPONSE REGULATOR receiver
I634_RS13735	COG2205	protein histidine kinase activity
I634_RS13775	COG2080	2 iron, 2 sulfur cluster binding
I634_RS13780	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I634_RS13785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I634_RS13805	COG1028	Short-chain dehydrogenase reductase Sdr
I634_RS13810	COG4221	oxidoreductase activity
I634_RS13815	COG0693	protein deglycase activity
I634_RS13820	COG1295	ribonuclease BN
I634_RS13860	COG2814	Major facilitator Superfamily
I634_RS13875	COG0514	ATP-dependent DNA helicase (RecQ)
I634_RS13905	COG4251	negative regulation of phosphorylation
I634_RS13915	COG2133	pyrroloquinoline quinone binding
I634_RS13930	COG0830	nickel cation binding
I634_RS13955	COG0829	nickel cation binding
I634_RS13990	COG2198	Histidine kinase
I634_RS13990	COG0784	Response regulator, receiver
I634_RS13990	COG2205	protein histidine kinase activity
I634_RS13995	COG0745	RESPONSE REGULATOR receiver
I634_RS14000	COG1484	DNA-dependent DNA replication
I634_RS14015	COG1192	Involved in chromosome partitioning
I634_RS14075	COG0840	transmembrane signaling receptor activity
I634_RS14080	COG5001	Diguanylate cyclase
I634_RS14080	COG3300	MHYT domain
I634_RS14085	COG3177	Filamentation induced by cAMP protein fic
I634_RS14115	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I634_RS14210	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I634_RS14210	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I634_RS14225	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I634_RS14230	COG2971	BadF BadG BcrA BcrD
I634_RS14235	COG0583	DNA-binding transcription factor activity
I634_RS14240	COG1620	l-lactate permease
I634_RS14260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I634_RS14265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I634_RS14270	COG0006	proline dipeptidase activity
I634_RS14280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I634_RS14295	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I634_RS14300	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I634_RS14305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I634_RS14325	COG3313	Fe-S protein
I634_RS14360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I634_RS14365	COG0508	dehydrogenase complex catalyzes the overall conversion of
I634_RS14370	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I634_RS14385	COG3023	N-Acetylmuramoyl-L-alanine amidase
I634_RS14390	COG3577	Aspartyl protease
I634_RS14395	COG0157	Belongs to the NadC ModD family
I634_RS14400	COG4969	Belongs to the N-Me-Phe pilin family
I634_RS14405	COG1459	type II secretion system
I634_RS14410	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I634_RS14415	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I634_RS14415	COG0237	dephospho-CoA kinase activity
I634_RS14420	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I634_RS14425	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I634_RS14430	COG3608	succinylglutamate desuccinylase aspartoacylase
I634_RS14435	COG0494	nUDIX hydrolase
I634_RS14445	COG0739	heme binding
I634_RS14450	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I634_RS14455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I634_RS14460	COG0849	cell division
I634_RS14465	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I634_RS14470	COG1181	Belongs to the D-alanine--D-alanine ligase family
I634_RS14475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I634_RS14485	COG0772	Belongs to the SEDS family
I634_RS14490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I634_RS14500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I634_RS14505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I634_RS14510	COG0768	penicillin binding
I634_RS14515	COG3116	cell division
I634_RS14525	COG2001	Belongs to the MraZ family
I634_RS14565	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I634_RS14565	COG0678	peroxiredoxin activity
I634_RS14590	COG2204	response regulator
I634_RS14595	COG0784	Response regulator, receiver
I634_RS14595	COG2205	protein histidine kinase activity
I634_RS14620	COG0668	transmembrane transport
I634_RS14625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I634_RS14630	COG0189	ligase activity
I634_RS14635	COG1678	Uncharacterized ACR, COG1678
I634_RS14640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I634_RS14665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I634_RS14670	COG0762	integral membrane protein
I634_RS14680	COG1902	pentaerythritol trinitrate reductase activity
I634_RS14680	COG0446	pyridine nucleotide-disulphide oxidoreductase
I634_RS14695	COG0625	glutathione transferase activity
I634_RS14705	COG1764	response to oxidative stress
I634_RS14710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I634_RS14725	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I634_RS14730	COG1396	sequence-specific DNA binding
I634_RS14735	COG2814	Major facilitator Superfamily
I634_RS14740	COG0724	RNA recognition motif
I634_RS14765	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I634_RS14770	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I634_RS14775	COG0083	homoserine kinase activity
I634_RS14790	COG0583	DNA-binding transcription factor activity
I634_RS14805	COG0640	Transcriptional regulator
I634_RS14815	COG0431	NADPH-dependent FMN reductase
I634_RS14820	COG0798	PFAM Bile acid sodium symporter
I634_RS14825	COG2201	protein-glutamate methylesterase activity
I634_RS14830	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I634_RS14840	COG0642	Histidine kinase
I634_RS14855	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I634_RS14885	COG1748	Saccharopine dehydrogenase
I634_RS14900	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I634_RS14905	COG3107	peptidoglycan biosynthetic process
I634_RS14915	COG0438	transferase activity, transferring glycosyl groups
I634_RS14925	COG2823	Periplasmic or secreted lipoprotein
I634_RS14945	COG4585	Histidine kinase
I634_RS14950	COG2197	response regulator
I634_RS14965	COG4771	TonB-dependent receptor
I634_RS14975	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I634_RS14980	COG0372	Belongs to the citrate synthase family
I634_RS14985	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I634_RS14990	COG2828	Protein conserved in bacteria
I634_RS14995	COG2199	diguanylate cyclase activity
I634_RS14995	COG2203	Gaf domain
I634_RS15000	COG1940	carbohydrate kinase activity
I634_RS15020	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I634_RS15040	COG5002	protein histidine kinase activity
I634_RS15040	COG2198	Histidine kinase
I634_RS15040	COG0784	Response regulator, receiver
I634_RS15045	COG3023	N-Acetylmuramoyl-L-alanine amidase
I634_RS15050	COG0070	glutamate synthase
I634_RS15050	COG0069	glutamate synthase activity
I634_RS15050	COG0067	glutamate synthase
I634_RS15055	COG0493	'glutamate synthase
I634_RS15070	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I634_RS15075	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I634_RS15080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I634_RS15085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I634_RS15100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I634_RS15105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I634_RS15115	COG4942	peptidase
I634_RS15120	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I634_RS15125	COG0738	Major facilitator superfamily
I634_RS15135	COG1902	pentaerythritol trinitrate reductase activity
I634_RS15155	COG0625	glutathione transferase activity
I634_RS15180	COG2894	cell division
I634_RS15185	COG0850	regulation of cytokinetic process
I634_RS15195	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I634_RS15210	COG1981	membrane
I634_RS15225	COG1914	H( )-stimulated, divalent metal cation uptake system
I634_RS15240	COG1217	gtp-binding protein TYPA
I634_RS15245	COG0174	glutamine synthetase
I634_RS15255	COG3852	Histidine kinase
I634_RS15260	COG2204	response regulator
I634_RS15265	COG3437	response regulator, receiver
I634_RS15305	COG3850	Histidine kinase
I634_RS15305	COG3437	response regulator, receiver
I634_RS15305	COG4999	Histidine kinase
I634_RS15305	COG2205	protein histidine kinase activity
I634_RS15310	COG0525	valine-tRNA ligase activity
I634_RS15315	COG2927	DNA polymerase III (CHI subunit)
I634_RS15320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I634_RS15325	COG0795	lipopolysaccharide-transporting ATPase activity
I634_RS15330	COG0795	lipopolysaccharide-transporting ATPase activity
I634_RS15430	COG3250	beta-galactosidase activity
I634_RS15440	COG4948	Mandelate Racemase Muconate Lactonizing
I634_RS15445	COG3661	Belongs to the glycosyl hydrolase 67 family
I634_RS15460	COG2199	diguanylate cyclase activity
I634_RS15460	COG2203	Gaf domain
I634_RS15490	COG0673	inositol 2-dehydrogenase activity
I634_RS15495	COG0784	Response regulator, receiver
I634_RS15495	COG2198	Histidine kinase
I634_RS15495	COG2205	protein histidine kinase activity
I634_RS15500	COG0628	permease
I634_RS15515	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I634_RS15520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I634_RS15525	COG4558	Periplasmic binding protein
I634_RS15535	COG4206	TonB-dependent receptor
I634_RS15570	COG4447	cellulose binding
I634_RS15580	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I634_RS15600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I634_RS15640	COG1131	(ABC) transporter
I634_RS15660	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I634_RS15700	COG2205	protein histidine kinase activity
I634_RS15710	COG0348	domain, Protein
I634_RS15710	COG3901	Regulator of nitric oxide reductase transcription
I634_RS15720	COG2197	response regulator
I634_RS15750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I634_RS15765	COG4771	TonB-dependent receptor
I634_RS15775	COG0583	DNA-binding transcription factor activity
I634_RS15780	COG1304	FMN binding
I634_RS15785	COG0277	FAD linked oxidase domain protein
I634_RS15795	COG1462	curli production assembly transport component CsgG
I634_RS15825	COG2197	response regulator
I634_RS15835	COG1028	Short-chain dehydrogenase reductase Sdr
I634_RS15850	COG0513	Belongs to the DEAD box helicase family
I634_RS15860	COG5001	Diguanylate cyclase
I634_RS15875	COG0800	Aldolase
I634_RS15895	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I634_RS15895	COG3264	Mechanosensitive ion channel
I634_RS15915	COG0840	transmembrane signaling receptor activity
I634_RS15940	COG0730	response to heat
I634_RS15945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I634_RS15960	COG4191	Histidine kinase
I634_RS15970	COG0417	DNA replication proofreading
I634_RS15980	COG0318	PFAM AMP-dependent synthetase and ligase
I634_RS16015	COG1309	transcriptional regulator
I634_RS16025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I634_RS16035	COG1573	uracil-dna glycosylase
I634_RS16040	COG3437	response regulator, receiver
I634_RS16040	COG0784	Response regulator, receiver
I634_RS16060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I634_RS16080	COG1983	PspC domain protein
I634_RS16085	COG1842	Phage shock protein A
I634_RS16095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I634_RS16130	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I634_RS16140	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I634_RS16145	COG0204	Acyl-transferase
I634_RS16150	COG0204	Acyl-transferase
I634_RS16155	COG0204	Acyl-transferase
I634_RS16160	COG0668	transmembrane transport
I634_RS16175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I634_RS16180	COG0733	neurotransmitter:sodium symporter activity
I634_RS16195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I634_RS16220	COG0848	biopolymer transport protein
I634_RS16240	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I634_RS16250	COG1215	transferase activity, transferring glycosyl groups
I634_RS16260	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I634_RS16265	COG0702	epimerase
I634_RS16280	COG5001	Diguanylate cyclase
I634_RS16280	COG5002	protein histidine kinase activity
I634_RS16290	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I634_RS16300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I634_RS16310	COG0583	DNA-binding transcription factor activity
I634_RS16315	COG0121	glutamine amidotransferase
I634_RS16325	COG4682	membrane
I634_RS16345	COG1953	Uracil, thiamine, allantoin
I634_RS16350	COG4771	TonB-dependent receptor
I634_RS16360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I634_RS16365	COG0778	Nitroreductase
I634_RS16370	COG0596	Alpha beta hydrolase
I634_RS16375	COG0251	oxidation-reduction process
I634_RS16380	COG1335	isochorismatase
I634_RS16385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I634_RS16390	COG1309	transcriptional regulator
I634_RS16405	COG4628	conserved protein (DUF2132)
I634_RS16410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I634_RS16420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I634_RS16440	COG1477	protein flavinylation
I634_RS16445	COG2871	sodium ion transport
I634_RS16450	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I634_RS16455	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I634_RS16460	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I634_RS16465	COG1805	sodium ion transport
I634_RS16470	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I634_RS16475	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I634_RS16480	COG0545	Peptidyl-prolyl cis-trans isomerase
I634_RS16485	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I634_RS16500	COG0039	L-malate dehydrogenase activity
I634_RS16505	COG1438	arginine binding
I634_RS16530	COG0572	uridine kinase
I634_RS16535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I634_RS16560	COG2176	DNA-directed DNA polymerase activity
I634_RS16570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I634_RS16590	COG0189	ligase activity
I634_RS16600	COG4067	protein conserved in archaea
I634_RS16600	COG0189	ligase activity
I634_RS16615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I634_RS16625	COG1283	sodium-dependent phosphate transmembrane transporter activity
I634_RS16630	COG0667	Aldo Keto reductase
I634_RS16660	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I634_RS16670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I634_RS16720	COG2274	protein secretion by the type I secretion system
I634_RS16725	COG0583	DNA-binding transcription factor activity
I634_RS16750	COG1216	Glycosyl transferase, family 2
I634_RS16750	COG0438	transferase activity, transferring glycosyl groups
I634_RS16760	COG1091	dTDP-4-dehydrorhamnose reductase activity
I634_RS16770	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I634_RS16775	COG0457	Tetratricopeptide repeat
I634_RS16840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I634_RS16850	COG2161	toxin-antitoxin pair type II binding
I634_RS16860	COG0202	RNA polymerase activity
I634_RS16885	COG0201	protein transport
I634_RS16905	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I634_RS16940	COG5002	protein histidine kinase activity
I634_RS16940	COG0784	Response regulator, receiver
I634_RS16960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I634_RS16965	COG0557	exoribonuclease II activity
I634_RS17010	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I634_RS17025	COG0543	2 iron, 2 sulfur cluster binding
I634_RS17040	COG2234	aminopeptidase activity
I634_RS17050	COG4251	negative regulation of phosphorylation
I634_RS17060	COG1271	oxidase subunit
I634_RS17065	COG1294	oxidase, subunit
I634_RS17070	COG1522	sequence-specific DNA binding
I634_RS17080	COG1278	Cold shock
I634_RS17085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I634_RS17105	COG0339	signal peptide processing
I634_RS17110	COG2201	protein-glutamate methylesterase activity
I634_RS17120	COG3852	Histidine kinase
I634_RS17130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I634_RS17135	COG0243	molybdopterin cofactor binding
I634_RS17140	COG4946	Tricorn protease homolog
I634_RS17140	COG0823	Involved in the tonB-independent uptake of proteins
I634_RS17140	COG1506	peptidase
I634_RS17185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I634_RS17195	COG2197	response regulator
I634_RS17205	COG0189	ligase activity
I634_RS17225	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I634_RS17230	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I634_RS17235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I634_RS17250	COG0281	malic enzyme
I634_RS17260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I634_RS17290	COG0456	acetyltransferase
I634_RS17300	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I634_RS17305	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I634_RS17310	COG2177	Part of the ABC transporter FtsEX involved in
I634_RS17315	COG2884	Cell division ATP-binding protein ftsE
I634_RS17325	COG0742	ribosomal rna small subunit methyltransferase
I634_RS17335	COG2095	MarC family integral membrane protein
I634_RS17355	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I634_RS17360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I634_RS17365	COG0617	tRNA 3'-terminal CCA addition
I634_RS17370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I634_RS17385	COG0076	glutamate decarboxylase activity
I634_RS17400	COG0842	Transport permease protein
I634_RS17405	COG1131	(ABC) transporter
I634_RS17410	COG0745	RESPONSE REGULATOR receiver
I634_RS17415	COG2205	protein histidine kinase activity
I634_RS17420	COG4774	siderophore transport
I634_RS17430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I634_RS17435	COG0049	tRNA binding
I634_RS17440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I634_RS17445	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I634_RS17450	COG0085	RNA polymerase activity
I634_RS17455	COG0222	ribosome binding
I634_RS17460	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I634_RS17465	COG0081	regulation of translation
I634_RS17470	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I634_RS17490	COG1132	(ABC) transporter
I634_RS17495	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I634_RS17500	COG3590	peptidase
I634_RS17510	COG0513	Belongs to the DEAD box helicase family
I634_RS17515	COG0418	dihydroorotase activity
I634_RS17520	COG3040	lipid binding
I634_RS17525	COG4989	oxidoreductase activity
I634_RS17530	COG0346	lactoylglutathione lyase activity
I634_RS17535	COG0668	transmembrane transport
I634_RS17555	COG0302	gtp cyclohydrolase
I634_RS17565	COG2957	Belongs to the agmatine deiminase family
I634_RS17570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I634_RS17580	COG1201	RNA secondary structure unwinding
I634_RS17590	COG1793	dna ligase
I634_RS17595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I634_RS17600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I634_RS17615	COG0625	glutathione transferase activity
I634_RS17620	COG0625	glutathione transferase activity
I634_RS17630	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I634_RS17645	COG1012	belongs to the aldehyde dehydrogenase family
I634_RS17650	COG0028	Belongs to the TPP enzyme family
I634_RS17660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I634_RS17665	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I634_RS17670	COG0330	HflC and HflK could
I634_RS17675	COG0330	HflC and HflK could
I634_RS17680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I634_RS17685	COG1923	regulation of RNA biosynthetic process
I634_RS17690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I634_RS17705	COG0802	atpase or kinase
I634_RS17710	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I634_RS17710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I634_RS17715	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I634_RS17735	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I634_RS17740	COG0735	belongs to the Fur family
I634_RS17760	COG0305	Participates in initiation and elongation during chromosome replication
I634_RS17785	COG2258	MOSC domain
I634_RS17815	COG2198	Histidine kinase
I634_RS17815	COG0784	Response regulator, receiver
I634_RS17815	COG2205	protein histidine kinase activity
I634_RS17825	COG0577	efflux transmembrane transporter activity
I634_RS17825	COG1136	(ABC) transporter
I634_RS17835	COG0840	transmembrane signaling receptor activity
I634_RS17840	COG5002	protein histidine kinase activity
I634_RS17845	COG0840	transmembrane signaling receptor activity
I634_RS17870	COG1757	Na H antiporter
I634_RS17875	COG1472	Belongs to the glycosyl hydrolase 3 family
I634_RS17885	COG2723	6-phospho-beta-galactosidase activity
I634_RS17890	COG1609	Transcriptional regulator
I634_RS17895	COG2814	Major facilitator Superfamily
I634_RS17895	COG0477	Major facilitator Superfamily
I634_RS17900	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I634_RS17905	COG4988	ABC transporter
I634_RS17915	COG1294	oxidase, subunit
I634_RS17955	COG4319	ketosteroid isomerase
I634_RS17975	COG2375	cellular response to nickel ion
I634_RS17980	COG3237	CsbD-like
I634_RS18005	COG0596	Alpha beta hydrolase
I634_RS18005	COG0508	dehydrogenase complex catalyzes the overall conversion of
I634_RS18025	COG3038	cytochrome b561
I634_RS18035	COG1252	NADH dehydrogenase
I634_RS18050	COG0583	DNA-binding transcription factor activity
I634_RS18055	COG2067	long-chain fatty acid transport protein
I634_RS18060	COG2130	NADP-dependent
I634_RS18065	COG3706	GGDEF domain
I634_RS18065	COG4251	negative regulation of phosphorylation
I634_RS18065	COG2203	Gaf domain
I634_RS18065	COG5001	Diguanylate cyclase
I634_RS18070	COG2205	protein histidine kinase activity
I634_RS18070	COG0784	Response regulator, receiver
I634_RS18080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I634_RS18085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I634_RS18090	COG1349	DNA-binding transcription factor activity
I634_RS18095	COG0673	inositol 2-dehydrogenase activity
I634_RS18110	COG0697	spore germination
I634_RS18115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I634_RS18120	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I634_RS18125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I634_RS18130	COG1166	arginine decarboxylase activity
I634_RS18140	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I634_RS18195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I634_RS18200	COG0109	protoheme IX farnesyltransferase activity
I634_RS18220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I634_RS18235	COG1487	ribonuclease activity
I634_RS18270	COG1324	tolerance protein
I634_RS18275	COG4232	protein-disulfide reductase activity
I634_RS18280	COG0739	heme binding
I634_RS18285	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I634_RS18290	COG0511	ligase activity, forming carbon-carbon bonds
I634_RS18295	COG0439	Biotin carboxylase
I634_RS18340	COG0154	amidase activity
I634_RS18355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I634_RS18360	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I634_RS18375	COG0151	Belongs to the GarS family
I634_RS18390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I634_RS18395	COG3954	Phosphoribulokinase
I634_RS18420	COG1501	Belongs to the glycosyl hydrolase 31 family
I634_RS18425	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I634_RS18435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I634_RS18445	COG3031	protein transport across the cell outer membrane
I634_RS18455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I634_RS18460	COG1459	type II secretion system
I634_RS18465	COG2165	general secretion pathway protein
I634_RS18470	COG2165	general secretion pathway protein
I634_RS18475	COG2165	general secretion pathway protein
I634_RS18480	COG4795	General secretion pathway protein
I634_RS18495	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I634_RS18510	COG1012	belongs to the aldehyde dehydrogenase family
I634_RS18520	COG1011	Hydrolase
I634_RS18525	COG0494	nUDIX hydrolase
I634_RS18530	COG1218	3'(2'),5'-bisphosphate nucleotidase
I634_RS18540	COG2943	transferase activity, transferring hexosyl groups
I634_RS18545	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I634_RS18555	COG3089	Belongs to the UPF0270 family
I634_RS18560	COG0429	hydrolase of the alpha beta-hydrolase fold
I634_RS18570	COG0488	(ABC) transporter
I634_RS18585	COG2900	Belongs to the SlyX family
I634_RS18595	COG0545	Peptidyl-prolyl cis-trans isomerase
I634_RS18605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I634_RS18610	COG2183	response to ionizing radiation
I634_RS18630	COG0596	Alpha beta hydrolase
I634_RS18635	COG1040	competence protein
I634_RS18655	COG1794	racemase activity, acting on amino acids and derivatives
I634_RS18665	COG0534	Mate efflux family protein
I634_RS18680	COG1999	signal sequence binding
I634_RS18685	COG0109	protoheme IX farnesyltransferase activity
I634_RS18690	COG1612	heme a metabolic process
I634_RS18710	COG1845	cytochrome c oxidase, subunit III
I634_RS18715	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I634_RS18720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I634_RS18725	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I634_RS18735	COG3706	GGDEF domain
I634_RS18750	COG0129	dihydroxy-acid dehydratase activity
I634_RS18765	COG0606	chelatase, subunit chli
I634_RS18780	COG2814	Major facilitator Superfamily
I634_RS18790	COG0729	surface antigen
I634_RS18795	COG2911	Protein conserved in bacteria
I634_RS18820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I634_RS18830	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I634_RS18850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I634_RS18875	COG1228	amidohydrolase
I634_RS18900	COG0425	Belongs to the sulfur carrier protein TusA family
I634_RS18915	COG1561	YicC-like family, N-terminal region
I634_RS19010	COG3177	Filamentation induced by cAMP protein fic
I634_RS19020	COG1609	Transcriptional regulator
I634_RS19035	COG2199	diguanylate cyclase activity
I634_RS19035	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I634_RS19060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I634_RS19080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I634_RS19085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I634_RS19105	COG1475	DNA binding
I634_RS19110	COG1192	Involved in chromosome partitioning
I634_RS19135	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I634_RS19150	COG0706	membrane insertase activity
I634_RS19155	COG0594	ribonuclease P activity
I634_RS19195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I634_RS19245	COG5002	protein histidine kinase activity
I634_RS19245	COG3447	MASE1 domain protein
I634_RS19245	COG5001	Diguanylate cyclase
I634_RS19260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I634_RS19390	COG3279	Response regulator of the LytR AlgR family
I634_RS19480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I634_RS19500	COG5001	Diguanylate cyclase
I634_RS19595	COG5507	3-demethylubiquinone-9 3-methyltransferase
I634_RS19615	COG4890	Cyd operon protein YbgT
I634_RS19625	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I634_RS19630	COG0230	Belongs to the bacterial ribosomal protein bL34 family