locus-tag	class	description
I636_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I636_RS00040	COG2818	Glycosylase
I636_RS00050	COG3078	GTPase activator activity
I636_RS00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I636_RS00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I636_RS00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I636_RS00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I636_RS00085	COG0569	domain protein
I636_RS00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I636_RS00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I636_RS00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I636_RS00110	COG0758	DNA mediated transformation
I636_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
I636_RS00130	COG0408	coproporphyrinogen oxidase activity
I636_RS00135	COG3047	cAMP biosynthetic process
I636_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I636_RS00235	COG2234	aminopeptidase activity
I636_RS00240	COG0463	Glycosyl transferase, family 2
I636_RS00250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I636_RS00275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I636_RS00305	COG3642	lipopolysaccharide core region biosynthetic process
I636_RS00310	COG0859	PFAM glycosyl transferase family 9
I636_RS00340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I636_RS00355	COG3161	chorismate lyase activity
I636_RS00360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I636_RS00380	COG0210	DNA helicase
I636_RS00410	COG1757	Na H antiporter
I636_RS00425	COG1959	2 iron, 2 sulfur cluster binding
I636_RS00430	COG0730	response to heat
I636_RS00445	COG4771	TonB-dependent receptor
I636_RS00460	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I636_RS00465	COG4988	ABC transporter
I636_RS00475	COG1271	oxidase subunit
I636_RS00485	COG0425	Belongs to the sulfur carrier protein TusA family
I636_RS00485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I636_RS00495	COG0450	alkyl hydroperoxide reductase
I636_RS00505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I636_RS00535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I636_RS00580	COG0270	DNA (cytosine-5-)-methyltransferase activity
I636_RS00585	COG0556	nucleotide-excision repair
I636_RS00595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_RS00600	COG1129	ABC transporter
I636_RS00600	COG0842	Transport permease protein
I636_RS00605	COG0842	Transport permease protein
I636_RS00620	COG1960	acyl-CoA dehydrogenase activity
I636_RS00625	COG0583	DNA-binding transcription factor activity
I636_RS00635	COG3106	COG3106 Predicted ATPase
I636_RS00650	COG2184	nucleotidyltransferase activity
I636_RS00655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I636_RS00670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I636_RS00675	COG0352	thiamine-phosphate diphosphorylase activity
I636_RS00685	COG3071	HemY protein
I636_RS00690	COG2959	enzyme of heme biosynthesis
I636_RS00700	COG0181	hydroxymethylbilane synthase activity
I636_RS00715	COG0194	GDP metabolic process
I636_RS00725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I636_RS00735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I636_RS00740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I636_RS00750	COG0678	peroxiredoxin activity
I636_RS00765	COG1178	ABC-type Fe3 transport system permease component
I636_RS00770	COG3842	ATPase activity
I636_RS00775	COG0668	transmembrane transport
I636_RS00780	COG2081	HI0933 family
I636_RS00800	COG4372	Transposase
I636_RS00815	COG2963	transposase activity
I636_RS00820	COG2801	Transposase and inactivated derivatives
I636_RS00835	COG2200	EAL domain
I636_RS00840	COG0583	DNA-binding transcription factor activity
I636_RS00865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_RS00880	COG0427	acetyl-CoA hydrolase
I636_RS00885	COG0123	including yeast histone deacetylase and acetoin utilization protein
I636_RS00900	COG0840	transmembrane signaling receptor activity
I636_RS00910	COG3064	Membrane
I636_RS00920	COG5002	protein histidine kinase activity
I636_RS00920	COG5001	Diguanylate cyclase
I636_RS00935	COG0514	ATP-dependent DNA helicase (RecQ)
I636_RS00940	COG2239	Acts as a magnesium transporter
I636_RS00945	COG2962	Rard protein
I636_RS00955	COG0210	DNA helicase
I636_RS00965	COG1011	Hydrolase
I636_RS00970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I636_RS00980	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I636_RS00985	COG0019	diaminopimelate decarboxylase activity
I636_RS01015	COG0163	prenyltransferase activity
I636_RS01020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I636_RS01030	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I636_RS01050	COG1077	Cell shape determining protein MreB Mrl
I636_RS01060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I636_RS01065	COG2814	Major facilitator Superfamily
I636_RS01070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I636_RS01095	COG1085	galactose-1-phosphate uridylyltransferase
I636_RS01100	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I636_RS01110	COG0629	single-stranded DNA binding
I636_RS01125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I636_RS01130	COG3250	beta-galactosidase activity
I636_RS01150	COG1349	DNA-binding transcription factor activity
I636_RS01195	COG3267	Type II secretory pathway component ExeA
I636_RS01195	COG3409	Peptidoglycan-binding domain 1 protein
I636_RS01205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I636_RS01210	COG1459	type II secretion system
I636_RS01220	COG2165	general secretion pathway protein
I636_RS01225	COG2165	general secretion pathway protein
I636_RS01255	COG1077	Cell shape determining protein MreB Mrl
I636_RS01260	COG1792	Involved in formation and maintenance of cell shape
I636_RS01265	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I636_RS01275	COG1530	ribonuclease E activity
I636_RS01285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I636_RS01290	COG0312	modulator of DNA gyrase
I636_RS01295	COG3028	Belongs to the UPF0307 family
I636_RS01300	COG0312	modulator of DNA gyrase
I636_RS01310	COG0745	RESPONSE REGULATOR receiver
I636_RS01315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I636_RS01315	COG4191	Histidine kinase
I636_RS01320	COG0297	glycogen (starch) synthase activity
I636_RS01330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I636_RS01335	COG0596	Alpha beta hydrolase
I636_RS01370	COG5002	protein histidine kinase activity
I636_RS01375	COG0745	RESPONSE REGULATOR receiver
I636_RS01395	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I636_RS01460	COG1017	nitric oxide dioxygenase activity
I636_RS01460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I636_RS01480	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I636_RS01510	COG0375	protein maturation
I636_RS01520	COG0409	Hydrogenase expression formation protein
I636_RS01530	COG0309	Hydrogenase expression formation protein (HypE)
I636_RS01535	COG0789	Transcriptional regulator
I636_RS01540	COG2217	Heavy metal translocating P-type atpase
I636_RS01625	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I636_RS01635	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I636_RS01645	COG0463	Glycosyl transferase, family 2
I636_RS01650	COG0745	RESPONSE REGULATOR receiver
I636_RS01655	COG5002	protein histidine kinase activity
I636_RS01685	COG0789	Transcriptional regulator
I636_RS01690	COG2217	Heavy metal translocating P-type atpase
I636_RS01725	COG0531	amino acid
I636_RS01780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I636_RS01785	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I636_RS01790	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I636_RS01805	COG1185	polyribonucleotide nucleotidyltransferase activity
I636_RS01830	COG1819	glycosyl
I636_RS01910	COG1609	Transcriptional regulator
I636_RS01915	COG0673	inositol 2-dehydrogenase activity
I636_RS01925	COG2211	Major facilitator Superfamily
I636_RS01950	COG1454	alcohol dehydrogenase
I636_RS01995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I636_RS02015	COG0089	rRNA binding
I636_RS02025	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I636_RS02035	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I636_RS02050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I636_RS02055	COG0438	transferase activity, transferring glycosyl groups
I636_RS02065	COG1519	Transferase
I636_RS02100	COG0788	formyltetrahydrofolate deformylase activity
I636_RS02110	COG1643	Atp-dependent helicase
I636_RS02115	COG2951	lytic endotransglycosylase activity
I636_RS02120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I636_RS02130	COG2354	Protein conserved in bacteria
I636_RS02150	COG0004	ammonium transporteR
I636_RS02155	COG0405	Gamma-glutamyltransferase
I636_RS02160	COG2837	iron assimilation
I636_RS02175	COG0540	Belongs to the ATCase OTCase family
I636_RS02200	COG2205	protein histidine kinase activity
I636_RS02200	COG0784	Response regulator, receiver
I636_RS02200	COG5002	protein histidine kinase activity
I636_RS02215	COG3300	MHYT domain
I636_RS02215	COG5001	Diguanylate cyclase
I636_RS02225	COG1012	belongs to the aldehyde dehydrogenase family
I636_RS02235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I636_RS02250	COG0180	Tryptophanyl-tRNA synthetase
I636_RS02255	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I636_RS02275	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I636_RS02285	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I636_RS02320	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I636_RS02325	COG0281	malic enzyme
I636_RS02335	COG0625	glutathione transferase activity
I636_RS02345	COG0753	catalase activity
I636_RS02360	COG5001	Diguanylate cyclase
I636_RS02360	COG3300	MHYT domain
I636_RS02365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I636_RS02365	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I636_RS02375	COG0137	argininosuccinate synthase activity
I636_RS02395	COG1803	Methylglyoxal synthase
I636_RS02405	COG0745	RESPONSE REGULATOR receiver
I636_RS02410	COG2205	protein histidine kinase activity
I636_RS02415	COG2267	carboxylic ester hydrolase activity
I636_RS02420	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I636_RS02430	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I636_RS02440	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I636_RS02445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I636_RS02450	COG4942	peptidase
I636_RS02455	COG2861	carbohydrate metabolic process
I636_RS02480	COG1162	GTPase activity
I636_RS02485	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I636_RS02515	COG0028	Belongs to the TPP enzyme family
I636_RS02535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I636_RS02540	COG0805	protein transport
I636_RS02550	COG0084	hydrolase, TatD family'
I636_RS02555	COG2203	Gaf domain
I636_RS02555	COG5001	Diguanylate cyclase
I636_RS02555	COG4251	negative regulation of phosphorylation
I636_RS02555	COG3706	GGDEF domain
I636_RS02565	COG0248	Ppx GppA phosphatase
I636_RS02570	COG0513	Belongs to the DEAD box helicase family
I636_RS02575	COG3118	belongs to the thioredoxin family
I636_RS02580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I636_RS02585	COG1473	amidohydrolase
I636_RS02590	COG0784	Response regulator, receiver
I636_RS02590	COG5002	protein histidine kinase activity
I636_RS02595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I636_RS02600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I636_RS02605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I636_RS02620	COG0783	Belongs to the Dps family
I636_RS02625	COG2133	pyrroloquinoline quinone binding
I636_RS02630	COG1506	peptidase
I636_RS02630	COG4946	Tricorn protease homolog
I636_RS02630	COG0823	Involved in the tonB-independent uptake of proteins
I636_RS02640	COG3118	belongs to the thioredoxin family
I636_RS02655	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I636_RS02665	COG1012	belongs to the aldehyde dehydrogenase family
I636_RS02685	COG1757	Na H antiporter
I636_RS02700	COG3876	Protein conserved in bacteria
I636_RS02705	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I636_RS02715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I636_RS02725	COG0346	lactoylglutathione lyase activity
I636_RS02750	COG2824	Alkylphosphonate utilization operon protein PhnA
I636_RS02755	COG0454	-acetyltransferase
I636_RS02785	COG3093	addiction module antidote protein HigA
I636_RS02800	COG2026	Addiction module toxin, RelE StbE family
I636_RS02885	COG0183	Belongs to the thiolase family
I636_RS02890	COG1250	3-hydroxyacyl-CoA dehydrogenase
I636_RS02890	COG1024	Enoyl-CoA hydratase
I636_RS02900	COG0006	proline dipeptidase activity
I636_RS02910	COG0142	geranyltranstransferase activity
I636_RS02940	COG4942	peptidase
I636_RS02940	COG1388	LysM domain
I636_RS02945	COG1238	metal cluster binding
I636_RS02955	COG0585	pseudouridine synthase activity
I636_RS02960	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I636_RS02970	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I636_RS02980	COG0840	transmembrane signaling receptor activity
I636_RS03015	COG0494	nUDIX hydrolase
I636_RS03020	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I636_RS03025	COG0730	response to heat
I636_RS03030	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I636_RS03035	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I636_RS03070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I636_RS03080	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I636_RS03090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I636_RS03090	COG1648	precorrin-2 dehydrogenase activity
I636_RS03095	COG0513	Belongs to the DEAD box helicase family
I636_RS03110	COG1538	Outer membrane efflux protein
I636_RS03115	COG0494	nUDIX hydrolase
I636_RS03125	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I636_RS03130	COG3150	esterase
I636_RS03135	COG0187	DNA topoisomerase II activity
I636_RS03145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I636_RS03170	COG1509	lysine 2,3-aminomutase activity
I636_RS03175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I636_RS03180	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I636_RS03195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I636_RS03210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I636_RS03225	COG0271	Belongs to the BolA IbaG family
I636_RS03240	COG3707	response regulator
I636_RS03255	COG0659	secondary active sulfate transmembrane transporter activity
I636_RS03260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I636_RS03270	COG0243	molybdopterin cofactor binding
I636_RS03275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I636_RS03275	COG1648	precorrin-2 dehydrogenase activity
I636_RS03280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I636_RS03290	COG1116	anion transmembrane transporter activity
I636_RS03290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I636_RS03300	COG1116	anion transmembrane transporter activity
I636_RS03315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I636_RS03320	COG4206	TonB-dependent receptor
I636_RS03330	COG0348	domain, Protein
I636_RS03345	COG1960	acyl-CoA dehydrogenase activity
I636_RS03350	COG1028	Short-chain dehydrogenase reductase Sdr
I636_RS03360	COG4948	Mandelate Racemase Muconate Lactonizing
I636_RS03375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_RS03380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I636_RS03405	COG0358	DNA primase activity
I636_RS03430	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I636_RS03435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I636_RS03450	COG0537	adenosine 5'-monophosphoramidase activity
I636_RS03465	COG3135	benzoate transporter
I636_RS03470	COG1396	sequence-specific DNA binding
I636_RS03475	COG2974	May be involved in recombination
I636_RS03480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I636_RS03480	COG4191	Histidine kinase
I636_RS03485	COG0745	RESPONSE REGULATOR receiver
I636_RS03490	COG5002	protein histidine kinase activity
I636_RS03515	COG0811	peptide transport
I636_RS03520	COG0811	peptide transport
I636_RS03525	COG0848	biopolymer transport protein
I636_RS03530	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I636_RS03540	COG3437	response regulator, receiver
I636_RS03560	COG2133	pyrroloquinoline quinone binding
I636_RS03570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I636_RS03595	COG0527	aspartate kinase activity
I636_RS03600	COG0840	transmembrane signaling receptor activity
I636_RS03605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I636_RS03610	COG2967	ApaG domain
I636_RS03620	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I636_RS03625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I636_RS03630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I636_RS03635	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I636_RS03645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I636_RS03665	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I636_RS03680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I636_RS03685	COG3956	TIGRFAM MazG family protein
I636_RS03710	COG1028	Short-chain dehydrogenase reductase Sdr
I636_RS03720	COG0318	PFAM AMP-dependent synthetase and ligase
I636_RS03730	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I636_RS03740	COG0463	Glycosyl transferase, family 2
I636_RS03760	COG0642	Histidine kinase
I636_RS03780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I636_RS03785	COG0723	plastoquinol--plastocyanin reductase activity
I636_RS03790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I636_RS03795	COG2857	Cytochrome c1
I636_RS03800	COG0625	glutathione transferase activity
I636_RS03805	COG2969	positive regulation of protein catabolic process
I636_RS03810	COG2239	Acts as a magnesium transporter
I636_RS03815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I636_RS03835	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I636_RS03840	COG1137	ATPase activity
I636_RS03845	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I636_RS03855	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I636_RS03870	COG1127	ABC transporter
I636_RS03875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I636_RS03880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I636_RS03885	COG2854	intermembrane phospholipid transfer
I636_RS03895	COG5007	Belongs to the BolA IbaG family
I636_RS03905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I636_RS03910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I636_RS03920	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I636_RS03955	COG4771	TonB-dependent receptor
I636_RS03960	COG0697	spore germination
I636_RS03970	COG0784	Response regulator, receiver
I636_RS03970	COG2205	protein histidine kinase activity
I636_RS03995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I636_RS04005	COG0126	phosphoglycerate kinase activity
I636_RS04010	COG3588	fructose-bisphosphate aldolase
I636_RS04020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_RS04030	COG1538	Outer membrane efflux protein
I636_RS04035	COG1506	peptidase
I636_RS04035	COG0823	Involved in the tonB-independent uptake of proteins
I636_RS04035	COG4946	Tricorn protease homolog
I636_RS04040	COG0248	Ppx GppA phosphatase
I636_RS04045	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I636_RS04055	COG0573	inorganic phosphate transmembrane transporter activity
I636_RS04065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I636_RS04075	COG0306	phosphate transporter
I636_RS04085	COG0583	DNA-binding transcription factor activity
I636_RS04095	COG1272	protein, Hemolysin III
I636_RS04100	COG1846	Transcriptional regulator
I636_RS04105	COG1764	response to oxidative stress
I636_RS04120	COG1739	Uncharacterized protein family UPF0029
I636_RS04140	COG0420	3'-5' exonuclease activity
I636_RS04145	COG0419	ATPase involved in DNA repair
I636_RS04155	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I636_RS04170	COG2188	Transcriptional regulator
I636_RS04175	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I636_RS04180	COG2986	histidine ammonia-lyase
I636_RS04205	COG0488	(ABC) transporter
I636_RS04225	COG0668	transmembrane transport
I636_RS04275	COG3547	Transposase (IS116 IS110 IS902 family)
I636_RS04320	COG0582	viral genome integration into host DNA
I636_RS04325	COG4372	Transposase
I636_RS04345	COG1484	DNA-dependent DNA replication
I636_RS04405	COG1346	cytolysis
I636_RS04435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I636_RS04445	COG0513	Belongs to the DEAD box helicase family
I636_RS04455	COG3409	Peptidoglycan-binding domain 1 protein
I636_RS04455	COG3267	Type II secretory pathway component ExeA
I636_RS04470	COG0066	3-isopropylmalate dehydratase activity
I636_RS04480	COG0473	3-isopropylmalate dehydrogenase activity
I636_RS04485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I636_RS04505	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I636_RS04520	COG4555	ABC transporter
I636_RS04525	COG1668	transmembrane transport
I636_RS04540	COG4133	protoheme IX ABC transporter activity
I636_RS04545	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I636_RS04550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I636_RS04555	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I636_RS04565	COG1138	Cytochrome C-type biogenesis protein
I636_RS04570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I636_RS04585	COG2853	Lipoprotein
I636_RS04590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I636_RS04630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I636_RS04645	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I636_RS04650	COG1555	photosystem II stabilization
I636_RS04650	COG1596	polysaccharide export
I636_RS04655	COG0473	3-isopropylmalate dehydrogenase activity
I636_RS04670	COG1611	Belongs to the LOG family
I636_RS04680	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I636_RS04680	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I636_RS04735	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I636_RS04740	COG0024	Methionine aminopeptidase
I636_RS04745	COG0052	Belongs to the universal ribosomal protein uS2 family
I636_RS04755	COG0528	UMP kinase activity
I636_RS04770	COG0575	Belongs to the CDS family
I636_RS04795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I636_RS04800	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I636_RS04815	COG0587	DNA-directed DNA polymerase activity
I636_RS04820	COG0825	malonyl-CoA metabolic process
I636_RS04825	COG0037	tRNA processing
I636_RS04855	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I636_RS04855	COG0047	phosphoribosylformylglycinamidine synthase activity
I636_RS04860	COG2840	Smr protein MutS2
I636_RS04890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_RS04895	COG2197	response regulator
I636_RS04925	COG5433	transposase activity
I636_RS04935	COG0835	chemotaxis
I636_RS04935	COG0784	Response regulator, receiver
I636_RS04940	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I636_RS04945	COG1815	bacterial-type flagellum-dependent cell motility
I636_RS04965	COG4787	bacterial-type flagellum-dependent cell motility
I636_RS04985	COG1705	Flagellar rod assembly protein muramidase FlgJ
I636_RS04985	COG3951	Flagellar rod assembly protein muramidase FlgJ
I636_RS04990	COG1256	bacterial-type flagellum assembly
I636_RS05005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I636_RS05015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I636_RS05030	COG1516	flagellar protein fliS
I636_RS05045	COG1086	Polysaccharide biosynthesis protein
I636_RS05050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I636_RS05060	COG2089	acid synthase
I636_RS05075	COG1028	Short-chain dehydrogenase reductase Sdr
I636_RS05125	COG1660	Displays ATPase and GTPase activities
I636_RS05130	COG1216	Glycosyl transferase, family 2
I636_RS05145	COG1083	cytidylyl-transferase
I636_RS05170	COG1677	Flagellar hook-basal body complex protein FliE
I636_RS05175	COG1766	The M ring may be actively involved in energy transduction
I636_RS05180	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I636_RS05230	COG1987	bacterial-type flagellum assembly
I636_RS05245	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I636_RS05270	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I636_RS05275	COG0643	Histidine kinase
I636_RS05275	COG2198	Histidine kinase
I636_RS05275	COG0784	Response regulator, receiver
I636_RS05285	COG1192	Involved in chromosome partitioning
I636_RS05295	COG0835	chemotaxis
I636_RS05310	COG0646	methionine synthase
I636_RS05310	COG1410	methionine synthase
I636_RS05315	COG1410	methionine synthase
I636_RS05315	COG0646	methionine synthase
I636_RS05325	COG3123	guanosine phosphorylase activity
I636_RS05330	COG0583	DNA-binding transcription factor activity
I636_RS05335	COG0583	DNA-binding transcription factor activity
I636_RS05345	COG0288	reversible hydration of carbon dioxide
I636_RS05350	COG0659	secondary active sulfate transmembrane transporter activity
I636_RS05365	COG3590	peptidase
I636_RS05375	COG2137	regulation of response to DNA damage stimulus
I636_RS05380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I636_RS05410	COG5016	pyruvate
I636_RS05410	COG0511	ligase activity, forming carbon-carbon bonds
I636_RS05415	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I636_RS05420	COG4172	Belongs to the ABC transporter superfamily
I636_RS05430	COG4171	peptide transport system, permease
I636_RS05435	COG4168	peptide transport system, permease
I636_RS05440	COG0747	negative chemotaxis
I636_RS05445	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I636_RS05450	COG1842	Phage shock protein A
I636_RS05480	COG0625	glutathione transferase activity
I636_RS05485	COG1522	sequence-specific DNA binding
I636_RS05545	COG0811	peptide transport
I636_RS05550	COG0811	peptide transport
I636_RS05555	COG0848	biopolymer transport protein
I636_RS05570	COG1444	tRNA N-acetyltransferase activity
I636_RS05610	COG0456	acetyltransferase
I636_RS05625	COG0583	DNA-binding transcription factor activity
I636_RS05630	COG2814	Major facilitator Superfamily
I636_RS05635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I636_RS05640	COG0656	L-ascorbic acid biosynthetic process
I636_RS05660	COG1846	Transcriptional regulator
I636_RS05670	COG3620	sequence-specific DNA binding
I636_RS05675	COG3550	peptidyl-serine autophosphorylation
I636_RS05710	COG0668	transmembrane transport
I636_RS05720	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I636_RS05740	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I636_RS05815	COG0789	Transcriptional regulator
I636_RS05830	COG1283	sodium-dependent phosphate transmembrane transporter activity
I636_RS05885	COG0789	Transcriptional regulator
I636_RS05900	COG0789	Transcriptional regulator
I636_RS05905	COG0640	Transcriptional regulator
I636_RS05915	COG1230	cation diffusion facilitator family transporter
I636_RS05950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I636_RS05965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I636_RS05980	COG0681	Belongs to the peptidase S26 family
I636_RS06000	COG1074	ATP-dependent DNA helicase activity
I636_RS06010	COG1404	Belongs to the peptidase S8 family
I636_RS06015	COG0464	growth
I636_RS06035	COG0629	single-stranded DNA binding
I636_RS06050	COG0714	Associated with various cellular activities
I636_RS06075	COG2003	Belongs to the UPF0758 family
I636_RS06095	COG0583	DNA-binding transcription factor activity
I636_RS06185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I636_RS06235	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I636_RS06240	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I636_RS06245	COG0564	pseudouridine synthase activity
I636_RS06255	COG0612	Peptidase, M16
I636_RS06260	COG2918	glutathione biosynthetic process
I636_RS06280	COG2840	Smr protein MutS2
I636_RS06285	COG2890	protein-(glutamine-N5) methyltransferase activity
I636_RS06300	COG2719	SpoVR family
I636_RS06305	COG2718	Belongs to the UPF0229 family
I636_RS06310	COG2766	serine protein kinase
I636_RS06315	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I636_RS06320	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I636_RS06325	COG4771	TonB-dependent receptor
I636_RS06350	COG0450	alkyl hydroperoxide reductase
I636_RS06355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I636_RS06360	COG2885	chlorophyll binding
I636_RS06365	COG0584	glycerophosphoryl diester phosphodiesterase
I636_RS06370	COG0346	lactoylglutathione lyase activity
I636_RS06375	COG1278	Cold shock
I636_RS06390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I636_RS06395	COG4660	Part of a membrane complex involved in electron transport
I636_RS06400	COG4659	FMN binding
I636_RS06405	COG4658	electron transport chain
I636_RS06410	COG4656	Part of a membrane complex involved in electron transport
I636_RS06415	COG2878	Part of a membrane complex involved in electron transport
I636_RS06420	COG4657	Part of a membrane complex involved in electron transport
I636_RS06435	COG0534	Mate efflux family protein
I636_RS06440	COG0556	nucleotide-excision repair
I636_RS06455	COG0602	queuosine metabolic process
I636_RS06465	COG0367	asparagine synthase
I636_RS06490	COG3273	potassium ion transport
I636_RS06490	COG0471	metal ion transport
I636_RS06505	COG0529	Catalyzes the synthesis of activated sulfate
I636_RS06510	COG0175	sulfate reduction
I636_RS06535	COG0471	metal ion transport
I636_RS06535	COG3273	potassium ion transport
I636_RS06550	COG0529	Catalyzes the synthesis of activated sulfate
I636_RS06555	COG0175	sulfate reduction
I636_RS06560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I636_RS06565	COG3706	GGDEF domain
I636_RS06590	COG2304	oxidoreductase activity
I636_RS06610	COG0714	Associated with various cellular activities
I636_RS06620	COG1024	Enoyl-CoA hydratase
I636_RS06620	COG1250	3-hydroxyacyl-CoA dehydrogenase
I636_RS06635	COG1025	Belongs to the peptidase M16 family
I636_RS06640	COG2062	phosphohistidine phosphatase, SixA
I636_RS06650	COG4536	flavin adenine dinucleotide binding
I636_RS06655	COG4137	Cytochrome C assembly protein
I636_RS06660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I636_RS06705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_RS06710	COG1132	(ABC) transporter
I636_RS06725	COG0228	four-way junction DNA binding
I636_RS06730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I636_RS06735	COG0336	Belongs to the RNA methyltransferase TrmD family
I636_RS06740	COG0335	large ribosomal subunit rRNA binding
I636_RS06745	COG2860	membrane
I636_RS06755	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I636_RS06760	COG0287	Prephenate dehydrogenase
I636_RS06760	COG1605	Chorismate mutase
I636_RS06765	COG1605	Chorismate mutase
I636_RS06765	COG0077	Prephenate dehydratase
I636_RS06770	COG0745	RESPONSE REGULATOR receiver
I636_RS06775	COG0023	Translation Initiation Factor
I636_RS06805	COG2205	protein histidine kinase activity
I636_RS06815	COG2204	response regulator
I636_RS06835	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I636_RS06840	COG0494	nUDIX hydrolase
I636_RS06845	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I636_RS06850	COG0632	four-way junction helicase activity
I636_RS06855	COG2255	four-way junction helicase activity
I636_RS06860	COG0824	Thioesterase
I636_RS06865	COG0811	peptide transport
I636_RS06880	COG0823	Involved in the tonB-independent uptake of proteins
I636_RS06885	COG2885	chlorophyll binding
I636_RS06890	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I636_RS06910	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I636_RS06945	COG4667	esterase of the alpha-beta hydrolase superfamily
I636_RS06950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I636_RS06960	COG2205	protein histidine kinase activity
I636_RS06960	COG0784	Response regulator, receiver
I636_RS06975	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I636_RS06980	COG3038	cytochrome b561
I636_RS07000	COG0583	DNA-binding transcription factor activity
I636_RS07005	COG1451	nucleotide metabolic process
I636_RS07015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I636_RS07025	COG1309	transcriptional regulator
I636_RS07030	COG4774	siderophore transport
I636_RS07050	COG3706	GGDEF domain
I636_RS07060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I636_RS07060	COG3008	intermembrane lipid transfer
I636_RS07065	COG2995	paraquat-inducible protein a
I636_RS07080	COG0017	Asparaginyl-tRNA synthetase
I636_RS07095	COG0189	ligase activity
I636_RS07125	COG0156	8-amino-7-oxononanoate synthase activity
I636_RS07130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I636_RS07140	COG3340	Belongs to the peptidase S51 family
I636_RS07145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I636_RS07150	COG4139	cobalamin transport
I636_RS07155	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I636_RS07160	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I636_RS07175	COG5265	(ABC) transporter
I636_RS07180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I636_RS07190	COG0745	RESPONSE REGULATOR receiver
I636_RS07200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I636_RS07240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I636_RS07255	COG2755	lipolytic protein G-D-S-L family
I636_RS07260	COG4181	ATPase activity
I636_RS07265	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I636_RS07270	COG1090	epimerase
I636_RS07275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I636_RS07280	COG0628	permease
I636_RS07305	COG2350	Protein conserved in bacteria
I636_RS07310	COG0159	tryptophan synthase activity
I636_RS07320	COG0134	indole-3-glycerol-phosphate synthase activity
I636_RS07320	COG0135	phosphoribosylanthranilate isomerase activity
I636_RS07325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I636_RS07335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I636_RS07340	COG0613	PHP domain protein
I636_RS07345	COG0009	L-threonylcarbamoyladenylate synthase
I636_RS07355	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I636_RS07365	COG0656	L-ascorbic acid biosynthetic process
I636_RS07370	COG0110	maltose O-acetyltransferase activity
I636_RS07380	COG2733	membrane
I636_RS07400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_RS07405	COG0500	methyltransferase
I636_RS07410	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I636_RS07415	COG0497	DNA recombination
I636_RS07420	COG0783	Belongs to the Dps family
I636_RS07425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I636_RS07430	COG1454	alcohol dehydrogenase
I636_RS07435	COG1028	Short-chain dehydrogenase reductase Sdr
I636_RS07445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I636_RS07450	COG2610	gluconate transmembrane transporter activity
I636_RS07455	COG4771	TonB-dependent receptor
I636_RS07465	COG2198	Histidine kinase
I636_RS07465	COG0784	Response regulator, receiver
I636_RS07465	COG2205	protein histidine kinase activity
I636_RS07470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I636_RS07480	COG0484	heat shock protein binding
I636_RS07485	COG3909	cytochrome
I636_RS07490	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I636_RS07505	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I636_RS07510	COG0505	Belongs to the CarA family
I636_RS07515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I636_RS07520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I636_RS07545	COG0280	phosphate acetyltransferase
I636_RS07545	COG0857	belongs to the CobB CobQ family
I636_RS07560	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I636_RS07565	COG4535	Mg2 and Co2 transporter CorC
I636_RS07575	COG1702	phosphate starvation-inducible protein PhoH
I636_RS07585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I636_RS07615	COG1607	acyl-coa hydrolase
I636_RS07620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I636_RS07630	COG1115	amino acid carrier protein
I636_RS07665	COG0012	GTP binding
I636_RS07680	COG1064	alcohol dehydrogenase
I636_RS07695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I636_RS07705	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I636_RS07710	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I636_RS07715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I636_RS07725	COG2890	protein-(glutamine-N5) methyltransferase activity
I636_RS07730	COG3437	response regulator, receiver
I636_RS07730	COG0784	Response regulator, receiver
I636_RS07740	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I636_RS07750	COG0583	DNA-binding transcription factor activity
I636_RS07760	COG2363	Small membrane protein
I636_RS07775	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I636_RS07780	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I636_RS07785	COG0515	serine threonine protein kinase
I636_RS07790	COG2116	formate transmembrane transporter activity
I636_RS07805	COG0714	Associated with various cellular activities
I636_RS07810	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I636_RS07815	COG0033	Phosphoglucomutase
I636_RS07820	COG0058	SHG alpha-glucan phosphorylase activity
I636_RS07830	COG2988	succinylglutamate desuccinylase activity
I636_RS07865	COG1393	Belongs to the ArsC family
I636_RS07890	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I636_RS07920	COG3300	MHYT domain
I636_RS07920	COG5001	Diguanylate cyclase
I636_RS07945	COG1733	regulation of RNA biosynthetic process
I636_RS07950	COG5001	Diguanylate cyclase
I636_RS07950	COG3447	MASE1 domain protein
I636_RS07950	COG5002	protein histidine kinase activity
I636_RS07960	COG0402	S-adenosylhomocysteine deaminase activity
I636_RS07965	COG2351	hydroxyisourate hydrolase activity
I636_RS07980	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I636_RS07995	COG1309	transcriptional regulator
I636_RS08010	COG2252	PERMEase
I636_RS08015	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I636_RS08030	COG2203	Gaf domain
I636_RS08030	COG3706	GGDEF domain
I636_RS08030	COG5001	Diguanylate cyclase
I636_RS08030	COG4251	negative regulation of phosphorylation
I636_RS08035	COG3706	GGDEF domain
I636_RS08035	COG2203	Gaf domain
I636_RS08035	COG5001	Diguanylate cyclase
I636_RS08035	COG4251	negative regulation of phosphorylation
I636_RS08040	COG2205	protein histidine kinase activity
I636_RS08040	COG0784	Response regulator, receiver
I636_RS08055	COG2233	PERMEase
I636_RS08070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I636_RS08075	COG0730	response to heat
I636_RS08115	COG1028	Short-chain dehydrogenase reductase Sdr
I636_RS08120	COG3001	Fructosamine kinase
I636_RS08130	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I636_RS08145	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I636_RS08145	COG0662	Cupin 2, conserved barrel domain protein
I636_RS08150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I636_RS08160	COG1596	polysaccharide export
I636_RS08165	COG0489	protein tyrosine kinase activity
I636_RS08170	COG4464	protein tyrosine phosphatase activity
I636_RS08245	COG1215	transferase activity, transferring glycosyl groups
I636_RS08250	COG0438	transferase activity, transferring glycosyl groups
I636_RS08260	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I636_RS08295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I636_RS08295	COG0072	phenylalanine-tRNA ligase activity
I636_RS08310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I636_RS08320	COG1472	Belongs to the glycosyl hydrolase 3 family
I636_RS08325	COG2096	Adenosyltransferase
I636_RS08335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I636_RS08345	COG4591	ABC-type transport system involved in lipoprotein release permease component
I636_RS08370	COG0708	Exodeoxyribonuclease III
I636_RS08405	COG2814	Major facilitator Superfamily
I636_RS08440	COG4770	biotin carboxylase activity
I636_RS08445	COG1024	Enoyl-CoA hydratase
I636_RS08450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I636_RS08455	COG1960	acyl-CoA dehydrogenase activity
I636_RS08460	COG0789	Transcriptional regulator
I636_RS08465	COG0183	Belongs to the thiolase family
I636_RS08480	COG3706	GGDEF domain
I636_RS08490	COG2925	Exonuclease
I636_RS08540	COG1643	Atp-dependent helicase
I636_RS08560	COG3321	synthase
I636_RS08560	COG0604	alcohol dehydrogenase
I636_RS08565	COG0328	RNA-DNA hybrid ribonuclease activity
I636_RS08570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I636_RS08600	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I636_RS08605	COG1136	(ABC) transporter
I636_RS08610	COG4591	ABC-type transport system involved in lipoprotein release permease component
I636_RS08625	COG3724	N-succinylarginine dihydrolase activity
I636_RS08635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I636_RS08650	COG0746	molybdenum cofactor guanylyltransferase activity
I636_RS08655	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I636_RS08660	COG0243	molybdopterin cofactor binding
I636_RS08665	COG2153	protein acetylation
I636_RS08680	COG1530	ribonuclease E activity
I636_RS08695	COG0424	maF-like protein
I636_RS08700	COG1399	metal-binding, possibly nucleic acid-binding protein
I636_RS08710	COG0416	fatty acid biosynthetic process
I636_RS08715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I636_RS08720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I636_RS08730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I636_RS08735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I636_RS08745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I636_RS08760	COG0084	hydrolase, TatD family'
I636_RS08770	COG0702	epimerase
I636_RS08795	COG1028	Short-chain dehydrogenase reductase Sdr
I636_RS08800	COG0596	Alpha beta hydrolase
I636_RS08810	COG0183	Belongs to the thiolase family
I636_RS08815	COG1960	acyl-CoA dehydrogenase activity
I636_RS08835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I636_RS08845	COG0246	Mannitol dehydrogenase
I636_RS08865	COG0668	transmembrane transport
I636_RS08870	COG4771	TonB-dependent receptor
I636_RS08895	COG3437	response regulator, receiver
I636_RS08905	COG0195	Participates in both transcription termination and antitermination
I636_RS08920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I636_RS08935	COG1187	pseudouridine synthase activity
I636_RS08945	COG3153	acetyltransferase
I636_RS08945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I636_RS09020	COG1032	radical SAM domain protein
I636_RS09035	COG4771	TonB-dependent receptor
I636_RS09040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I636_RS09050	COG4134	Bacterial extracellular solute-binding protein
I636_RS09060	COG4136	ATPase activity
I636_RS09065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I636_RS09090	COG5001	Diguanylate cyclase
I636_RS09090	COG4251	negative regulation of phosphorylation
I636_RS09090	COG3706	GGDEF domain
I636_RS09090	COG2203	Gaf domain
I636_RS09115	COG1902	pentaerythritol trinitrate reductase activity
I636_RS09125	COG2867	negative regulation of translational initiation
I636_RS09130	COG2914	Belongs to the UPF0125 (RnfH) family
I636_RS09140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I636_RS09145	COG4771	TonB-dependent receptor
I636_RS09150	COG0457	Tetratricopeptide repeat
I636_RS09165	COG0574	Belongs to the PEP-utilizing enzyme family
I636_RS09165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I636_RS09200	COG2850	peptidyl-arginine hydroxylation
I636_RS09210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I636_RS09215	COG2915	High frequency lysogenization protein hflD homolog
I636_RS09220	COG0482	sulfurtransferase activity
I636_RS09225	COG1187	pseudouridine synthase activity
I636_RS09235	COG1278	Cold shock
I636_RS09240	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I636_RS09245	COG0542	response to heat
I636_RS09250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I636_RS09255	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I636_RS09260	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I636_RS09265	COG0492	ferredoxin-NADP+ reductase activity
I636_RS09275	COG3091	SprT-like family
I636_RS09280	COG0616	signal peptide processing
I636_RS09295	COG0778	Nitroreductase
I636_RS09305	COG0252	asparaginase activity
I636_RS09310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I636_RS09315	COG0321	lipoyl(octanoyl) transferase activity
I636_RS09320	COG2921	Belongs to the UPF0250 family
I636_RS09325	COG1686	Belongs to the peptidase S11 family
I636_RS09330	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I636_RS09335	COG0772	Belongs to the SEDS family
I636_RS09340	COG0768	penicillin binding
I636_RS09345	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I636_RS09350	COG0799	negative regulation of ribosome biogenesis
I636_RS09360	COG1466	dna polymerase III delta subunit
I636_RS09365	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I636_RS09370	COG0495	leucyl-tRNA aminoacylation
I636_RS09385	COG1067	ATP-dependent peptidase activity
I636_RS09390	COG0596	Alpha beta hydrolase
I636_RS09405	COG1534	Rna-binding protein
I636_RS09410	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I636_RS09415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I636_RS09420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I636_RS09425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I636_RS09430	COG0149	triose-phosphate isomerase activity
I636_RS09435	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I636_RS09445	COG5001	Diguanylate cyclase
I636_RS09445	COG3300	MHYT domain
I636_RS09465	COG1597	lipid kinase activity
I636_RS09465	COG1803	Methylglyoxal synthase
I636_RS09475	COG1028	Short-chain dehydrogenase reductase Sdr
I636_RS09480	COG0561	phosphatase activity
I636_RS09510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I636_RS09515	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I636_RS09520	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I636_RS09535	COG1185	polyribonucleotide nucleotidyltransferase activity
I636_RS09555	COG3547	Transposase (IS116 IS110 IS902 family)
I636_RS09635	COG4372	Transposase
I636_RS09665	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I636_RS09670	COG1196	nuclear chromosome segregation
I636_RS09680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I636_RS09695	COG1132	(ABC) transporter
I636_RS09700	COG1663	tetraacyldisaccharide 4'-kinase activity
I636_RS09735	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I636_RS09740	COG0435	Glutathione S-transferase
I636_RS09745	COG1741	Belongs to the pirin family
I636_RS09750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I636_RS09760	COG0372	Belongs to the citrate synthase family
I636_RS09770	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I636_RS09775	COG1053	succinate dehydrogenase
I636_RS09780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I636_RS09785	COG0567	Dehydrogenase, E1 component
I636_RS09790	COG0508	dehydrogenase complex catalyzes the overall conversion of
I636_RS09825	COG4667	esterase of the alpha-beta hydrolase superfamily
I636_RS09845	COG0366	Alpha amylase catalytic
I636_RS09870	COG1028	Short-chain dehydrogenase reductase Sdr
I636_RS09875	COG2267	carboxylic ester hydrolase activity
I636_RS09885	COG0616	signal peptide processing
I636_RS09905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I636_RS09910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I636_RS09915	COG0386	Belongs to the glutathione peroxidase family
I636_RS09920	COG2084	Dehydrogenase
I636_RS09930	COG1960	acyl-CoA dehydrogenase activity
I636_RS09935	COG1024	Enoyl-CoA hydratase
I636_RS09940	COG2226	methyltransferase
I636_RS09950	COG3083	sulfuric ester hydrolase activity
I636_RS09955	COG3082	Protein of unknown function (DUF1414)
I636_RS09960	COG3081	Nucleoid-associated protein
I636_RS09990	COG3275	phosphorelay sensor kinase activity
I636_RS09995	COG3279	Response regulator of the LytR AlgR family
I636_RS10000	COG0205	6-phosphofructokinase activity
I636_RS10015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I636_RS10030	COG2205	protein histidine kinase activity
I636_RS10030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I636_RS10040	COG1054	Belongs to the UPF0176 family
I636_RS10050	COG0513	Belongs to the DEAD box helicase family
I636_RS10060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I636_RS10065	COG0583	DNA-binding transcription factor activity
I636_RS10085	COG1760	l-serine dehydratase
I636_RS10110	COG1322	Protein conserved in bacteria
I636_RS10115	COG1404	Belongs to the peptidase S8 family
I636_RS10120	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I636_RS10125	COG0022	dehydrogenase e1 component
I636_RS10135	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I636_RS10140	COG0515	serine threonine protein kinase
I636_RS10145	COG1946	Acyl-CoA thioesterase
I636_RS10155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I636_RS10165	COG1956	GAF domain-containing protein
I636_RS10180	COG0793	Belongs to the peptidase S41A family
I636_RS10185	COG0733	neurotransmitter:sodium symporter activity
I636_RS10190	COG1757	Na H antiporter
I636_RS10195	COG0308	aminopeptidase N
I636_RS10225	COG2902	Dehydrogenase
I636_RS10230	COG0167	dihydroorotate dehydrogenase activity
I636_RS10245	COG0488	(ABC) transporter
I636_RS10255	COG3130	regulation of translation
I636_RS10260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I636_RS10270	COG0415	Belongs to the DNA photolyase family
I636_RS10275	COG0415	Belongs to the DNA photolyase family
I636_RS10280	COG0415	Belongs to the DNA photolyase family
I636_RS10285	COG3046	protein related to deoxyribodipyrimidine photolyase
I636_RS10305	COG2193	ferroxidase activity
I636_RS10315	COG3278	Belongs to the heme-copper respiratory oxidase family
I636_RS10330	COG2010	Cytochrome c
I636_RS10355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I636_RS10360	COG0589	response to stress
I636_RS10365	COG0037	tRNA processing
I636_RS10370	COG1752	Esterase of the alpha-beta hydrolase superfamily
I636_RS10390	COG1280	lysine exporter protein (LysE YggA)
I636_RS10400	COG2897	thiosulfate sulfurtransferase activity
I636_RS10405	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I636_RS10410	COG3148	PFAM DTW domain containing protein
I636_RS10435	COG0322	excinuclease ABC activity
I636_RS10440	COG2197	response regulator
I636_RS10445	COG0436	Aminotransferase
I636_RS10465	COG2259	Doxx family
I636_RS10470	COG0583	DNA-binding transcription factor activity
I636_RS10485	COG0670	Belongs to the BI1 family
I636_RS10490	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I636_RS10505	COG2920	part of a sulfur-relay system
I636_RS10535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I636_RS10545	COG1674	ftsk spoiiie
I636_RS10545	COG0531	amino acid
I636_RS10555	COG0686	Belongs to the AlaDH PNT family
I636_RS10560	COG0284	orotidine-5'-phosphate decarboxylase activity
I636_RS10565	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I636_RS10580	COG0776	regulation of translation
I636_RS10585	COG0539	negative regulation of cytoplasmic translation
I636_RS10590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I636_RS10595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I636_RS10600	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I636_RS10610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I636_RS10615	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I636_RS10620	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I636_RS10625	COG0633	Ferredoxin
I636_RS10655	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I636_RS10660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I636_RS10670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I636_RS10680	COG4783	chaperone-mediated protein folding
I636_RS10690	COG1393	Belongs to the ArsC family
I636_RS10705	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I636_RS10720	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I636_RS10730	COG1960	acyl-CoA dehydrogenase activity
I636_RS10755	COG0572	uridine kinase
I636_RS10760	COG3769	mannosylglycerate metabolic process
I636_RS10765	COG1215	transferase activity, transferring glycosyl groups
I636_RS10770	COG0366	Alpha amylase catalytic
I636_RS10780	COG0303	'Molybdopterin
I636_RS10785	COG0534	Mate efflux family protein
I636_RS10800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I636_RS10805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I636_RS10860	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I636_RS10880	COG3547	Transposase (IS116 IS110 IS902 family)
I636_RS10905	COG0405	Gamma-glutamyltransferase
I636_RS10910	COG1024	Enoyl-CoA hydratase
I636_RS10955	COG1448	Aminotransferase
I636_RS10965	COG1671	Belongs to the UPF0178 family
I636_RS10970	COG1028	Short-chain dehydrogenase reductase Sdr
I636_RS10975	COG1028	Short-chain dehydrogenase reductase Sdr
I636_RS10980	COG1960	acyl-CoA dehydrogenase activity
I636_RS10985	COG0662	Cupin 2, conserved barrel domain protein
I636_RS10985	COG2207	Transcriptional regulator
I636_RS11000	COG1505	serine-type exopeptidase activity
I636_RS11010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_RS11040	COG0596	Alpha beta hydrolase
I636_RS11050	COG0716	FMN binding
I636_RS11060	COG0735	belongs to the Fur family
I636_RS11070	COG1984	allophanate hydrolase subunit 2
I636_RS11075	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I636_RS11080	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I636_RS11085	COG2996	Protein conserved in bacteria
I636_RS11090	COG1765	OsmC-like protein
I636_RS11095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_RS11105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I636_RS11120	COG0436	Aminotransferase
I636_RS11125	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I636_RS11130	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I636_RS11140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I636_RS11140	COG2010	Cytochrome c
I636_RS11145	COG2080	2 iron, 2 sulfur cluster binding
I636_RS11170	COG1073	alpha beta
I636_RS11175	COG2207	Transcriptional regulator
I636_RS11185	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I636_RS11190	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I636_RS11215	COG3012	SEC-C Motif Domain Protein
I636_RS11220	COG0604	alcohol dehydrogenase
I636_RS11230	COG1960	acyl-CoA dehydrogenase activity
I636_RS11240	COG4771	TonB-dependent receptor
I636_RS11265	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I636_RS11285	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I636_RS11290	COG0315	cyclic pyranopterin monophosphate synthase activity
I636_RS11295	COG0521	Mo-molybdopterin cofactor biosynthetic process
I636_RS11310	COG2161	toxin-antitoxin pair type II binding
I636_RS11315	COG4115	mRNA cleavage
I636_RS11330	COG0436	Aminotransferase
I636_RS11335	COG3268	Saccharopine dehydrogenase
I636_RS11340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I636_RS11355	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I636_RS11360	COG4206	TonB-dependent receptor
I636_RS11370	COG5006	permease, DMT superfamily
I636_RS11385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I636_RS11390	COG1074	ATP-dependent DNA helicase activity
I636_RS11395	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I636_RS11410	COG1022	Amp-dependent synthetase and ligase
I636_RS11415	COG3706	GGDEF domain
I636_RS11415	COG4251	negative regulation of phosphorylation
I636_RS11415	COG2203	Gaf domain
I636_RS11415	COG5001	Diguanylate cyclase
I636_RS11435	COG0583	DNA-binding transcription factor activity
I636_RS11450	COG0640	Transcriptional regulator
I636_RS11470	COG2204	response regulator
I636_RS11480	COG4251	negative regulation of phosphorylation
I636_RS11485	COG0784	Response regulator, receiver
I636_RS11490	COG0784	Response regulator, receiver
I636_RS11490	COG2205	protein histidine kinase activity
I636_RS11515	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I636_RS11540	COG3139	Protein of unknown function (DUF1315)
I636_RS11555	COG1115	amino acid carrier protein
I636_RS11560	COG2866	Carboxypeptidase
I636_RS11580	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I636_RS11590	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I636_RS11595	COG1640	4-alpha-glucanotransferase
I636_RS11600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I636_RS11605	COG0676	glucose-6-phosphate 1-epimerase activity
I636_RS11610	COG0800	Aldolase
I636_RS11620	COG0129	dihydroxy-acid dehydratase activity
I636_RS11630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I636_RS11635	COG1737	Transcriptional regulator
I636_RS11640	COG0469	pyruvate kinase activity
I636_RS11655	COG1960	acyl-CoA dehydrogenase activity
I636_RS11675	COG0471	metal ion transport
I636_RS11675	COG0490	domain, Protein
I636_RS11685	COG0800	Aldolase
I636_RS11695	COG0129	dihydroxy-acid dehydratase activity
I636_RS11705	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I636_RS11710	COG1737	Transcriptional regulator
I636_RS11715	COG0469	pyruvate kinase activity
I636_RS11720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I636_RS11740	COG2823	Periplasmic or secreted lipoprotein
I636_RS11770	COG3665	Urea carboxylase-associated protein
I636_RS11800	COG2356	endonuclease I
I636_RS11805	COG0840	transmembrane signaling receptor activity
I636_RS11820	COG0583	DNA-binding transcription factor activity
I636_RS11825	COG1979	alcohol dehydrogenase
I636_RS11830	COG5001	Diguanylate cyclase
I636_RS11840	COG0784	Response regulator, receiver
I636_RS11840	COG3437	response regulator, receiver
I636_RS11970	COG0471	metal ion transport
I636_RS11980	COG0489	protein tyrosine kinase activity
I636_RS11985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I636_RS11985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I636_RS11990	COG0668	transmembrane transport
I636_RS11995	COG2226	methyltransferase
I636_RS12000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I636_RS12005	COG0741	lytic transglycosylase activity
I636_RS12005	COG1388	LysM domain
I636_RS12030	COG0215	cysteine-tRNA ligase activity
I636_RS12035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I636_RS12040	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I636_RS12050	COG2268	Band 7 protein
I636_RS12065	COG1733	regulation of RNA biosynthetic process
I636_RS12070	COG0604	alcohol dehydrogenase
I636_RS12075	COG0753	catalase activity
I636_RS12080	COG0604	alcohol dehydrogenase
I636_RS12120	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I636_RS12125	COG1286	toxin biosynthetic process
I636_RS12130	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I636_RS12135	COG0285	dihydrofolate synthase activity
I636_RS12155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I636_RS12160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I636_RS12180	COG3609	addiction module antidote protein, CC2985 family
I636_RS12190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I636_RS12195	COG0318	PFAM AMP-dependent synthetase and ligase
I636_RS12205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I636_RS12205	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I636_RS12240	COG0789	Transcriptional regulator
I636_RS12245	COG0604	alcohol dehydrogenase
I636_RS12270	COG1028	Short-chain dehydrogenase reductase Sdr
I636_RS12275	COG1119	ATPase activity
I636_RS12280	COG2031	fatty acid transporter
I636_RS12285	COG2205	protein histidine kinase activity
I636_RS12285	COG0784	Response regulator, receiver
I636_RS12285	COG5002	protein histidine kinase activity
I636_RS12295	COG0612	Peptidase, M16
I636_RS12310	COG3101	peptidyl-lysine hydroxylation
I636_RS12340	COG1902	pentaerythritol trinitrate reductase activity
I636_RS12340	COG0446	pyridine nucleotide-disulphide oxidoreductase
I636_RS12365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I636_RS12375	COG4399	Belongs to the UPF0754 family
I636_RS12400	COG1770	oligopeptidase
I636_RS12405	COG2186	Transcriptional regulator
I636_RS12415	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I636_RS12420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I636_RS12430	COG2983	Belongs to the UPF0260 family
I636_RS12435	COG0179	Fumarylacetoacetate (FAA) hydrolase
I636_RS12455	COG0318	PFAM AMP-dependent synthetase and ligase
I636_RS12460	COG2267	carboxylic ester hydrolase activity
I636_RS12475	COG1214	PFAM Peptidase M22, glycoprotease
I636_RS12480	COG1199	ATP-dependent helicase activity
I636_RS12530	COG4771	TonB-dependent receptor
I636_RS12540	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I636_RS12545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I636_RS12550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I636_RS12555	COG0131	Imidazoleglycerol-phosphate dehydratase
I636_RS12555	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I636_RS12560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I636_RS12590	COG2116	formate transmembrane transporter activity
I636_RS12595	COG0612	Peptidase, M16
I636_RS12625	COG0326	Molecular chaperone. Has ATPase activity
I636_RS12630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I636_RS12655	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I636_RS12665	COG3220	belongs to the UPF0276 family
I636_RS12675	COG1136	(ABC) transporter
I636_RS12675	COG0577	efflux transmembrane transporter activity
I636_RS12685	COG2203	Gaf domain
I636_RS12685	COG4251	negative regulation of phosphorylation
I636_RS12685	COG5001	Diguanylate cyclase
I636_RS12685	COG3706	GGDEF domain
I636_RS12715	COG1183	phosphatidylcholine synthase activity
I636_RS12735	COG0277	FAD linked oxidase domain protein
I636_RS12740	COG0542	response to heat
I636_RS12765	COG1595	DNA-templated transcription, initiation
I636_RS12780	COG4221	oxidoreductase activity
I636_RS12795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I636_RS12805	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I636_RS12815	COG0142	geranyltranstransferase activity
I636_RS12825	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I636_RS12830	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I636_RS12840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I636_RS12855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I636_RS12855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I636_RS12870	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I636_RS12875	COG0488	(ABC) transporter
I636_RS12885	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I636_RS12895	COG0560	Phosphoserine phosphatase
I636_RS12905	COG0084	hydrolase, TatD family'
I636_RS12920	COG0571	ribonuclease III activity
I636_RS12950	COG1595	DNA-templated transcription, initiation
I636_RS12955	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I636_RS12970	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I636_RS13050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I636_RS13055	COG1047	Peptidyl-prolyl cis-trans
I636_RS13065	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I636_RS13070	COG0196	riboflavin kinase activity
I636_RS13075	COG0728	peptidoglycan biosynthetic process
I636_RS13080	COG0268	Binds directly to 16S ribosomal RNA
I636_RS13100	COG0385	Bile acid
I636_RS13130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I636_RS13135	COG0776	regulation of translation
I636_RS13145	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I636_RS13150	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I636_RS13155	COG0740	serine-type endopeptidase activity
I636_RS13160	COG0544	peptidyl-prolyl cis-trans isomerase activity
I636_RS13190	COG1234	tRNA 3'-trailer cleavage
I636_RS13200	COG0123	including yeast histone deacetylase and acetoin utilization protein
I636_RS13215	COG0517	IMP dehydrogenase activity
I636_RS13215	COG0516	GMP reductase activity
I636_RS13220	COG1570	exodeoxyribonuclease VII activity
I636_RS13240	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I636_RS13245	COG2976	Protein conserved in bacteria
I636_RS13270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I636_RS13280	COG2166	iron-sulfur cluster assembly
I636_RS13295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I636_RS13300	COG0719	Fe-S assembly protein
I636_RS13305	COG0396	ATPase activity
I636_RS13310	COG0719	Fe-S assembly protein
I636_RS13315	COG1104	cysteine desulfurase activity
I636_RS13325	COG2072	flavoprotein involved in K transport
I636_RS13330	COG1045	serine acetyltransferase
I636_RS13335	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I636_RS13340	COG0483	inositol monophosphate 1-phosphatase activity
I636_RS13355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I636_RS13360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I636_RS13365	COG1862	Preprotein translocase
I636_RS13370	COG0343	queuine tRNA-ribosyltransferase activity
I636_RS13390	COG1842	Phage shock protein A
I636_RS13395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I636_RS13415	COG0754	glutathionylspermidine amidase activity
I636_RS13445	COG2066	Belongs to the glutaminase family
I636_RS13450	COG1785	Belongs to the alkaline phosphatase family
I636_RS13455	COG0745	RESPONSE REGULATOR receiver
I636_RS13525	COG0438	transferase activity, transferring glycosyl groups
I636_RS13545	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I636_RS13550	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I636_RS13580	COG2755	lipolytic protein G-D-S-L family
I636_RS13580	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I636_RS13585	COG0367	asparagine synthase
I636_RS13590	COG0438	transferase activity, transferring glycosyl groups
I636_RS13600	COG2244	polysaccharide biosynthetic process
I636_RS13630	COG0367	asparagine synthase
I636_RS13665	COG0489	protein tyrosine kinase activity
I636_RS13675	COG3267	Type II secretory pathway component ExeA
I636_RS13675	COG3409	Peptidoglycan-binding domain 1 protein
I636_RS13720	COG1560	Kdo2-lipid A biosynthetic process
I636_RS13735	COG1960	acyl-CoA dehydrogenase activity
I636_RS13750	COG3300	MHYT domain
I636_RS13750	COG5001	Diguanylate cyclase
I636_RS13755	COG1435	thymidine kinase activity
I636_RS13765	COG1609	Transcriptional regulator
I636_RS13770	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I636_RS13795	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I636_RS13800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I636_RS13805	COG1250	3-hydroxyacyl-CoA dehydrogenase
I636_RS13805	COG1024	Enoyl-CoA hydratase
I636_RS13820	COG1012	belongs to the aldehyde dehydrogenase family
I636_RS13840	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I636_RS13865	COG1960	acyl-CoA dehydrogenase activity
I636_RS13895	COG0745	RESPONSE REGULATOR receiver
I636_RS13900	COG2205	protein histidine kinase activity
I636_RS13940	COG2080	2 iron, 2 sulfur cluster binding
I636_RS13945	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I636_RS13950	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I636_RS13970	COG1028	Short-chain dehydrogenase reductase Sdr
I636_RS13975	COG4221	oxidoreductase activity
I636_RS13980	COG0693	protein deglycase activity
I636_RS13985	COG1295	ribonuclease BN
I636_RS14025	COG2814	Major facilitator Superfamily
I636_RS14040	COG0514	ATP-dependent DNA helicase (RecQ)
I636_RS14070	COG4251	negative regulation of phosphorylation
I636_RS14075	COG2133	pyrroloquinoline quinone binding
I636_RS14080	COG3609	addiction module antidote protein, CC2985 family
I636_RS14120	COG0330	HflC and HflK could
I636_RS14210	COG4772	TonB-dependent receptor
I636_RS14255	COG4372	Transposase
I636_RS14270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I636_RS14275	COG0508	dehydrogenase complex catalyzes the overall conversion of
I636_RS14280	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I636_RS14295	COG3023	N-Acetylmuramoyl-L-alanine amidase
I636_RS14300	COG3577	Aspartyl protease
I636_RS14305	COG0157	Belongs to the NadC ModD family
I636_RS14315	COG1459	type II secretion system
I636_RS14320	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I636_RS14325	COG0237	dephospho-CoA kinase activity
I636_RS14330	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I636_RS14335	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I636_RS14340	COG3608	succinylglutamate desuccinylase aspartoacylase
I636_RS14345	COG0494	nUDIX hydrolase
I636_RS14355	COG0739	heme binding
I636_RS14360	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I636_RS14365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I636_RS14370	COG0849	cell division
I636_RS14375	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I636_RS14380	COG1181	Belongs to the D-alanine--D-alanine ligase family
I636_RS14385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I636_RS14395	COG0772	Belongs to the SEDS family
I636_RS14400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I636_RS14410	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I636_RS14415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I636_RS14420	COG0768	penicillin binding
I636_RS14425	COG3116	cell division
I636_RS14435	COG2001	Belongs to the MraZ family
I636_RS14475	COG0678	peroxiredoxin activity
I636_RS14475	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I636_RS14500	COG2204	response regulator
I636_RS14505	COG0784	Response regulator, receiver
I636_RS14505	COG2205	protein histidine kinase activity
I636_RS14530	COG0668	transmembrane transport
I636_RS14535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I636_RS14540	COG0189	ligase activity
I636_RS14545	COG1678	Uncharacterized ACR, COG1678
I636_RS14550	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I636_RS14575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I636_RS14580	COG0762	integral membrane protein
I636_RS14590	COG0446	pyridine nucleotide-disulphide oxidoreductase
I636_RS14590	COG1902	pentaerythritol trinitrate reductase activity
I636_RS14605	COG0625	glutathione transferase activity
I636_RS14615	COG1764	response to oxidative stress
I636_RS14635	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I636_RS14640	COG1396	sequence-specific DNA binding
I636_RS14645	COG2814	Major facilitator Superfamily
I636_RS14650	COG0724	RNA recognition motif
I636_RS14665	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I636_RS14670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I636_RS14675	COG0083	homoserine kinase activity
I636_RS14690	COG0583	DNA-binding transcription factor activity
I636_RS14705	COG0640	Transcriptional regulator
I636_RS14715	COG0431	NADPH-dependent FMN reductase
I636_RS14720	COG0798	PFAM Bile acid sodium symporter
I636_RS14725	COG2201	protein-glutamate methylesterase activity
I636_RS14730	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I636_RS14740	COG0642	Histidine kinase
I636_RS14765	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I636_RS14790	COG1748	Saccharopine dehydrogenase
I636_RS14805	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I636_RS14810	COG3107	peptidoglycan biosynthetic process
I636_RS14820	COG0438	transferase activity, transferring glycosyl groups
I636_RS14830	COG2823	Periplasmic or secreted lipoprotein
I636_RS14850	COG4585	Histidine kinase
I636_RS14855	COG2197	response regulator
I636_RS14870	COG4771	TonB-dependent receptor
I636_RS14880	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I636_RS14885	COG0372	Belongs to the citrate synthase family
I636_RS14890	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I636_RS14895	COG2828	Protein conserved in bacteria
I636_RS14900	COG2203	Gaf domain
I636_RS14900	COG2199	diguanylate cyclase activity
I636_RS14905	COG1940	carbohydrate kinase activity
I636_RS14925	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I636_RS14945	COG0784	Response regulator, receiver
I636_RS14945	COG5002	protein histidine kinase activity
I636_RS14945	COG2198	Histidine kinase
I636_RS14950	COG3023	N-Acetylmuramoyl-L-alanine amidase
I636_RS14955	COG0067	glutamate synthase
I636_RS14955	COG0069	glutamate synthase activity
I636_RS14955	COG0070	glutamate synthase
I636_RS14960	COG0493	'glutamate synthase
I636_RS14975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I636_RS14980	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I636_RS14985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I636_RS14990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I636_RS15005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I636_RS15010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I636_RS15015	COG4942	peptidase
I636_RS15020	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I636_RS15025	COG0738	Major facilitator superfamily
I636_RS15035	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I636_RS15050	COG1981	membrane
I636_RS15065	COG1914	H( )-stimulated, divalent metal cation uptake system
I636_RS15080	COG1217	gtp-binding protein TYPA
I636_RS15085	COG0174	glutamine synthetase
I636_RS15095	COG3852	Histidine kinase
I636_RS15100	COG2204	response regulator
I636_RS15105	COG3437	response regulator, receiver
I636_RS15145	COG3437	response regulator, receiver
I636_RS15145	COG4999	Histidine kinase
I636_RS15145	COG3850	Histidine kinase
I636_RS15145	COG2205	protein histidine kinase activity
I636_RS15150	COG0525	valine-tRNA ligase activity
I636_RS15155	COG2927	DNA polymerase III (CHI subunit)
I636_RS15160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I636_RS15165	COG0795	lipopolysaccharide-transporting ATPase activity
I636_RS15170	COG0795	lipopolysaccharide-transporting ATPase activity
I636_RS15260	COG4974	Belongs to the 'phage' integrase family
I636_RS15275	COG2856	Zn peptidase
I636_RS15385	COG3250	beta-galactosidase activity
I636_RS15395	COG4948	Mandelate Racemase Muconate Lactonizing
I636_RS15400	COG3661	Belongs to the glycosyl hydrolase 67 family
I636_RS15415	COG2199	diguanylate cyclase activity
I636_RS15415	COG2203	Gaf domain
I636_RS15445	COG0673	inositol 2-dehydrogenase activity
I636_RS15455	COG0628	permease
I636_RS15470	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I636_RS15475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I636_RS15480	COG4558	Periplasmic binding protein
I636_RS15490	COG4206	TonB-dependent receptor
I636_RS15500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I636_RS15530	COG1971	Probably functions as a manganese efflux pump
I636_RS15540	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I636_RS15555	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I636_RS15565	COG0679	Auxin Efflux Carrier
I636_RS15595	COG1131	(ABC) transporter
I636_RS15615	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I636_RS15655	COG2205	protein histidine kinase activity
I636_RS15665	COG3901	Regulator of nitric oxide reductase transcription
I636_RS15665	COG0348	domain, Protein
I636_RS15675	COG2197	response regulator
I636_RS15700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I636_RS15715	COG4771	TonB-dependent receptor
I636_RS15725	COG0583	DNA-binding transcription factor activity
I636_RS15730	COG1304	FMN binding
I636_RS15735	COG0277	FAD linked oxidase domain protein
I636_RS15745	COG1462	curli production assembly transport component CsgG
I636_RS15775	COG2197	response regulator
I636_RS15790	COG0513	Belongs to the DEAD box helicase family
I636_RS15795	COG1294	oxidase, subunit
I636_RS15800	COG1271	oxidase subunit
I636_RS15815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I636_RS15825	COG2124	cytochrome p450
I636_RS15845	COG2203	Gaf domain
I636_RS15845	COG2199	diguanylate cyclase activity
I636_RS15865	COG2010	Cytochrome c
I636_RS15865	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I636_RS15870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I636_RS15900	COG2337	Toxic component of a toxin-antitoxin (TA) module
I636_RS15955	COG3264	Mechanosensitive ion channel
I636_RS15955	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I636_RS16000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I636_RS16015	COG1309	transcriptional regulator
I636_RS16025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I636_RS16035	COG1573	uracil-dna glycosylase
I636_RS16040	COG3300	MHYT domain
I636_RS16040	COG5001	Diguanylate cyclase
I636_RS16060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I636_RS16080	COG1983	PspC domain protein
I636_RS16085	COG1842	Phage shock protein A
I636_RS16095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I636_RS16120	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I636_RS16130	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I636_RS16135	COG0204	Acyl-transferase
I636_RS16140	COG0204	Acyl-transferase
I636_RS16145	COG0668	transmembrane transport
I636_RS16160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I636_RS16165	COG0733	neurotransmitter:sodium symporter activity
I636_RS16180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I636_RS16205	COG0848	biopolymer transport protein
I636_RS16220	COG0457	Tetratricopeptide repeat
I636_RS16225	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I636_RS16235	COG1215	transferase activity, transferring glycosyl groups
I636_RS16250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I636_RS16255	COG0702	epimerase
I636_RS16280	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I636_RS16290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I636_RS16300	COG0583	DNA-binding transcription factor activity
I636_RS16305	COG0121	glutamine amidotransferase
I636_RS16310	COG4682	membrane
I636_RS16330	COG1953	Uracil, thiamine, allantoin
I636_RS16335	COG4771	TonB-dependent receptor
I636_RS16345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I636_RS16350	COG0778	Nitroreductase
I636_RS16355	COG0596	Alpha beta hydrolase
I636_RS16360	COG0251	oxidation-reduction process
I636_RS16365	COG1335	isochorismatase
I636_RS16370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I636_RS16375	COG1309	transcriptional regulator
I636_RS16390	COG4628	conserved protein (DUF2132)
I636_RS16395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I636_RS16405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I636_RS16415	COG1477	protein flavinylation
I636_RS16420	COG2871	sodium ion transport
I636_RS16425	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I636_RS16430	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I636_RS16435	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I636_RS16440	COG1805	sodium ion transport
I636_RS16445	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I636_RS16450	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I636_RS16455	COG0545	Peptidyl-prolyl cis-trans isomerase
I636_RS16460	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I636_RS16475	COG0039	L-malate dehydrogenase activity
I636_RS16480	COG1438	arginine binding
I636_RS16505	COG0572	uridine kinase
I636_RS16510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I636_RS16535	COG2176	DNA-directed DNA polymerase activity
I636_RS16540	COG1125	glycine betaine transport
I636_RS16540	COG0517	IMP dehydrogenase activity
I636_RS16545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I636_RS16555	COG2205	protein histidine kinase activity
I636_RS16565	COG0189	ligase activity
I636_RS16575	COG0189	ligase activity
I636_RS16575	COG4067	protein conserved in archaea
I636_RS16590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I636_RS16600	COG1283	sodium-dependent phosphate transmembrane transporter activity
I636_RS16605	COG0667	Aldo Keto reductase
I636_RS16625	COG5001	Diguanylate cyclase
I636_RS16655	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I636_RS16665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I636_RS16670	COG0840	transmembrane signaling receptor activity
I636_RS16705	COG2274	protein secretion by the type I secretion system
I636_RS16710	COG0583	DNA-binding transcription factor activity
I636_RS16735	COG0438	transferase activity, transferring glycosyl groups
I636_RS16735	COG1216	Glycosyl transferase, family 2
I636_RS16775	COG0457	Tetratricopeptide repeat
I636_RS16805	COG1216	Glycosyl transferase, family 2
I636_RS16805	COG0463	Glycosyl transferase, family 2
I636_RS16900	COG4372	Transposase
I636_RS16920	COG4372	Transposase
I636_RS16970	COG2161	toxin-antitoxin pair type II binding
I636_RS16980	COG0202	RNA polymerase activity
I636_RS17005	COG0201	protein transport
I636_RS17025	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I636_RS17060	COG0784	Response regulator, receiver
I636_RS17060	COG5002	protein histidine kinase activity
I636_RS17080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I636_RS17085	COG0557	exoribonuclease II activity
I636_RS17115	COG4771	TonB-dependent receptor
I636_RS17130	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I636_RS17145	COG0543	2 iron, 2 sulfur cluster binding
I636_RS17160	COG2234	aminopeptidase activity
I636_RS17170	COG4251	negative regulation of phosphorylation
I636_RS17180	COG1271	oxidase subunit
I636_RS17185	COG1294	oxidase, subunit
I636_RS17190	COG1522	sequence-specific DNA binding
I636_RS17200	COG1278	Cold shock
I636_RS17205	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I636_RS17225	COG0339	signal peptide processing
I636_RS17230	COG2201	protein-glutamate methylesterase activity
I636_RS17240	COG3852	Histidine kinase
I636_RS17250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I636_RS17255	COG0243	molybdopterin cofactor binding
I636_RS17260	COG1506	peptidase
I636_RS17260	COG0823	Involved in the tonB-independent uptake of proteins
I636_RS17260	COG4946	Tricorn protease homolog
I636_RS17305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_RS17315	COG2197	response regulator
I636_RS17325	COG0189	ligase activity
I636_RS17345	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I636_RS17350	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I636_RS17355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I636_RS17370	COG0281	malic enzyme
I636_RS17380	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I636_RS17410	COG0456	acetyltransferase
I636_RS17420	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I636_RS17425	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I636_RS17430	COG2177	Part of the ABC transporter FtsEX involved in
I636_RS17435	COG2884	Cell division ATP-binding protein ftsE
I636_RS17440	COG0552	protein localization to endoplasmic reticulum
I636_RS17455	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I636_RS17460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I636_RS17465	COG0617	tRNA 3'-terminal CCA addition
I636_RS17470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I636_RS17485	COG0076	glutamate decarboxylase activity
I636_RS17500	COG0842	Transport permease protein
I636_RS17505	COG1131	(ABC) transporter
I636_RS17510	COG0745	RESPONSE REGULATOR receiver
I636_RS17515	COG2205	protein histidine kinase activity
I636_RS17520	COG4774	siderophore transport
I636_RS17540	COG1253	flavin adenine dinucleotide binding
I636_RS17550	COG1966	Carbon starvation protein
I636_RS17560	COG0657	acetylesterase activity
I636_RS17570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I636_RS17575	COG0049	tRNA binding
I636_RS17580	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I636_RS17585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I636_RS17590	COG0085	RNA polymerase activity
I636_RS17595	COG0222	ribosome binding
I636_RS17600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I636_RS17605	COG0081	regulation of translation
I636_RS17610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I636_RS17630	COG0250	Participates in transcription elongation, termination and antitermination
I636_RS17635	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I636_RS17645	COG1132	(ABC) transporter
I636_RS17650	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I636_RS17655	COG3590	peptidase
I636_RS17665	COG0513	Belongs to the DEAD box helicase family
I636_RS17670	COG0418	dihydroorotase activity
I636_RS17675	COG3040	lipid binding
I636_RS17680	COG4989	oxidoreductase activity
I636_RS17685	COG0346	lactoylglutathione lyase activity
I636_RS17690	COG0668	transmembrane transport
I636_RS17710	COG0302	gtp cyclohydrolase
I636_RS17720	COG2957	Belongs to the agmatine deiminase family
I636_RS17725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I636_RS17740	COG1201	RNA secondary structure unwinding
I636_RS17750	COG1793	dna ligase
I636_RS17755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I636_RS17760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I636_RS17770	COG1410	methionine synthase
I636_RS17770	COG0646	methionine synthase
I636_RS17775	COG0625	glutathione transferase activity
I636_RS17780	COG0625	glutathione transferase activity
I636_RS17790	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I636_RS17795	COG0330	HflC and HflK could
I636_RS17800	COG0330	HflC and HflK could
I636_RS17805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I636_RS17810	COG1923	regulation of RNA biosynthetic process
I636_RS17815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I636_RS17830	COG0802	atpase or kinase
I636_RS17835	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I636_RS17835	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I636_RS17840	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I636_RS17860	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I636_RS17865	COG0735	belongs to the Fur family
I636_RS17885	COG0305	Participates in initiation and elongation during chromosome replication
I636_RS17910	COG2258	MOSC domain
I636_RS17940	COG2205	protein histidine kinase activity
I636_RS17960	COG0840	transmembrane signaling receptor activity
I636_RS17965	COG5002	protein histidine kinase activity
I636_RS17970	COG0840	transmembrane signaling receptor activity
I636_RS17995	COG1757	Na H antiporter
I636_RS18000	COG1472	Belongs to the glycosyl hydrolase 3 family
I636_RS18010	COG2723	6-phospho-beta-galactosidase activity
I636_RS18015	COG1609	Transcriptional regulator
I636_RS18020	COG0477	Major facilitator Superfamily
I636_RS18020	COG2814	Major facilitator Superfamily
I636_RS18025	COG4319	ketosteroid isomerase
I636_RS18045	COG2375	cellular response to nickel ion
I636_RS18050	COG3237	CsbD-like
I636_RS18080	COG0508	dehydrogenase complex catalyzes the overall conversion of
I636_RS18080	COG0596	Alpha beta hydrolase
I636_RS18100	COG3038	cytochrome b561
I636_RS18110	COG1252	NADH dehydrogenase
I636_RS18125	COG0583	DNA-binding transcription factor activity
I636_RS18130	COG2067	long-chain fatty acid transport protein
I636_RS18135	COG2130	NADP-dependent
I636_RS18140	COG2203	Gaf domain
I636_RS18140	COG3706	GGDEF domain
I636_RS18140	COG4251	negative regulation of phosphorylation
I636_RS18140	COG5001	Diguanylate cyclase
I636_RS18145	COG0784	Response regulator, receiver
I636_RS18145	COG2205	protein histidine kinase activity
I636_RS18155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I636_RS18160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I636_RS18165	COG1349	DNA-binding transcription factor activity
I636_RS18170	COG0673	inositol 2-dehydrogenase activity
I636_RS18185	COG0697	spore germination
I636_RS18190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I636_RS18195	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I636_RS18200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I636_RS18205	COG1166	arginine decarboxylase activity
I636_RS18215	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I636_RS18295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I636_RS18300	COG0109	protoheme IX farnesyltransferase activity
I636_RS18320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I636_RS18335	COG1487	ribonuclease activity
I636_RS18365	COG3030	protein affecting phage T7 exclusion by the F plasmid
I636_RS18370	COG1324	tolerance protein
I636_RS18375	COG4232	protein-disulfide reductase activity
I636_RS18380	COG0739	heme binding
I636_RS18385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I636_RS18390	COG0511	ligase activity, forming carbon-carbon bonds
I636_RS18395	COG0439	Biotin carboxylase
I636_RS18440	COG0154	amidase activity
I636_RS18455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I636_RS18460	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I636_RS18475	COG0151	Belongs to the GarS family
I636_RS18490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I636_RS18495	COG3954	Phosphoribulokinase
I636_RS18520	COG1501	Belongs to the glycosyl hydrolase 31 family
I636_RS18525	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I636_RS18530	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I636_RS18540	COG3031	protein transport across the cell outer membrane
I636_RS18550	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I636_RS18555	COG1459	type II secretion system
I636_RS18560	COG2165	general secretion pathway protein
I636_RS18565	COG2165	general secretion pathway protein
I636_RS18570	COG2165	general secretion pathway protein
I636_RS18575	COG4795	General secretion pathway protein
I636_RS18590	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I636_RS18605	COG1012	belongs to the aldehyde dehydrogenase family
I636_RS18615	COG1011	Hydrolase
I636_RS18620	COG0494	nUDIX hydrolase
I636_RS18625	COG1218	3'(2'),5'-bisphosphate nucleotidase
I636_RS18635	COG2943	transferase activity, transferring hexosyl groups
I636_RS18640	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I636_RS18650	COG3089	Belongs to the UPF0270 family
I636_RS18655	COG0429	hydrolase of the alpha beta-hydrolase fold
I636_RS18665	COG0488	(ABC) transporter
I636_RS18680	COG2900	Belongs to the SlyX family
I636_RS18690	COG0545	Peptidyl-prolyl cis-trans isomerase
I636_RS18700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I636_RS18705	COG2183	response to ionizing radiation
I636_RS18730	COG2207	Transcriptional regulator
I636_RS18730	COG1609	Transcriptional regulator
I636_RS18735	COG2211	Major facilitator Superfamily
I636_RS18750	COG3693	PFAM glycoside hydrolase, family 10
I636_RS18755	COG0667	Aldo Keto reductase
I636_RS18760	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I636_RS18765	COG2115	Belongs to the xylose isomerase family
I636_RS18770	COG1070	Carbohydrate kinase
I636_RS18785	COG1472	Belongs to the glycosyl hydrolase 3 family
I636_RS18790	COG0477	Major facilitator Superfamily
I636_RS18835	COG0596	Alpha beta hydrolase
I636_RS18840	COG1040	competence protein
I636_RS18860	COG1794	racemase activity, acting on amino acids and derivatives
I636_RS18870	COG0534	Mate efflux family protein
I636_RS18885	COG1999	signal sequence binding
I636_RS18890	COG0109	protoheme IX farnesyltransferase activity
I636_RS18895	COG1612	heme a metabolic process
I636_RS18915	COG1845	cytochrome c oxidase, subunit III
I636_RS18920	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I636_RS18925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I636_RS18930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I636_RS18950	COG0129	dihydroxy-acid dehydratase activity
I636_RS18960	COG0606	chelatase, subunit chli
I636_RS18965	COG0583	DNA-binding transcription factor activity
I636_RS18975	COG2814	Major facilitator Superfamily
I636_RS18985	COG0729	surface antigen
I636_RS18990	COG2911	Protein conserved in bacteria
I636_RS19015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I636_RS19025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I636_RS19045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I636_RS19070	COG1228	amidohydrolase
I636_RS19095	COG0425	Belongs to the sulfur carrier protein TusA family
I636_RS19110	COG1561	YicC-like family, N-terminal region
I636_RS19120	COG3550	peptidyl-serine autophosphorylation
I636_RS19125	COG3620	sequence-specific DNA binding
I636_RS19210	COG3119	arylsulfatase activity
I636_RS19215	COG0714	Associated with various cellular activities
I636_RS19230	COG2304	oxidoreductase activity
I636_RS19260	COG0318	PFAM AMP-dependent synthetase and ligase
I636_RS19265	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I636_RS19275	COG1960	acyl-CoA dehydrogenase activity
I636_RS19320	COG3177	Filamentation induced by cAMP protein fic
I636_RS19330	COG1609	Transcriptional regulator
I636_RS19345	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I636_RS19345	COG2199	diguanylate cyclase activity
I636_RS19370	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I636_RS19390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I636_RS19395	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I636_RS19415	COG1475	DNA binding
I636_RS19420	COG1192	Involved in chromosome partitioning
I636_RS19445	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I636_RS19460	COG0706	membrane insertase activity
I636_RS19465	COG0594	ribonuclease P activity
I636_RS19470	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I636_RS19505	COG1216	Glycosyl transferase, family 2
I636_RS19555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I636_RS19635	COG2801	Transposase and inactivated derivatives
I636_RS19660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I636_RS19725	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I636_RS19755	COG0789	Transcriptional regulator
I636_RS19810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane