locus-tag	class	description
I635_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I635_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I635_RS00040	COG2818	Glycosylase
I635_RS00050	COG3078	GTPase activator activity
I635_RS00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I635_RS00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I635_RS00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I635_RS00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I635_RS00085	COG0569	domain protein
I635_RS00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I635_RS00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I635_RS00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I635_RS00110	COG0758	DNA mediated transformation
I635_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
I635_RS00130	COG0408	coproporphyrinogen oxidase activity
I635_RS00135	COG3047	cAMP biosynthetic process
I635_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I635_RS00225	COG2234	aminopeptidase activity
I635_RS00230	COG0463	Glycosyl transferase, family 2
I635_RS00240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I635_RS00265	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I635_RS00295	COG3642	lipopolysaccharide core region biosynthetic process
I635_RS00300	COG0859	PFAM glycosyl transferase family 9
I635_RS00330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I635_RS00345	COG3161	chorismate lyase activity
I635_RS00350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I635_RS00370	COG0210	DNA helicase
I635_RS00400	COG1757	Na H antiporter
I635_RS00415	COG1959	2 iron, 2 sulfur cluster binding
I635_RS00420	COG0730	response to heat
I635_RS00435	COG4771	TonB-dependent receptor
I635_RS00450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I635_RS00455	COG4988	ABC transporter
I635_RS00465	COG1271	oxidase subunit
I635_RS00475	COG0425	Belongs to the sulfur carrier protein TusA family
I635_RS00475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I635_RS00485	COG0450	alkyl hydroperoxide reductase
I635_RS00495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I635_RS00525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I635_RS00570	COG0270	DNA (cytosine-5-)-methyltransferase activity
I635_RS00575	COG0556	nucleotide-excision repair
I635_RS00585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_RS00590	COG1129	ABC transporter
I635_RS00590	COG0842	Transport permease protein
I635_RS00595	COG0842	Transport permease protein
I635_RS00610	COG1960	acyl-CoA dehydrogenase activity
I635_RS00615	COG0583	DNA-binding transcription factor activity
I635_RS00625	COG3106	COG3106 Predicted ATPase
I635_RS00640	COG2184	nucleotidyltransferase activity
I635_RS00645	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I635_RS00660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I635_RS00665	COG0352	thiamine-phosphate diphosphorylase activity
I635_RS00675	COG3071	HemY protein
I635_RS00680	COG2959	enzyme of heme biosynthesis
I635_RS00690	COG0181	hydroxymethylbilane synthase activity
I635_RS00705	COG0194	GDP metabolic process
I635_RS00715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I635_RS00725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I635_RS00730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I635_RS00740	COG0678	peroxiredoxin activity
I635_RS00760	COG1178	ABC-type Fe3 transport system permease component
I635_RS00765	COG3842	ATPase activity
I635_RS00770	COG0668	transmembrane transport
I635_RS00775	COG2081	HI0933 family
I635_RS00790	COG2963	transposase activity
I635_RS00825	COG0789	Transcriptional regulator
I635_RS00830	COG2963	transposase activity
I635_RS00835	COG2801	Transposase and inactivated derivatives
I635_RS00850	COG2200	EAL domain
I635_RS00855	COG0583	DNA-binding transcription factor activity
I635_RS00880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_RS00895	COG0427	acetyl-CoA hydrolase
I635_RS00900	COG0123	including yeast histone deacetylase and acetoin utilization protein
I635_RS00915	COG0840	transmembrane signaling receptor activity
I635_RS00925	COG3064	Membrane
I635_RS00935	COG5001	Diguanylate cyclase
I635_RS00935	COG5002	protein histidine kinase activity
I635_RS00950	COG0514	ATP-dependent DNA helicase (RecQ)
I635_RS00955	COG2239	Acts as a magnesium transporter
I635_RS00960	COG2962	Rard protein
I635_RS00970	COG0210	DNA helicase
I635_RS00980	COG1011	Hydrolase
I635_RS00985	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I635_RS00995	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I635_RS01000	COG0019	diaminopimelate decarboxylase activity
I635_RS01030	COG0163	prenyltransferase activity
I635_RS01035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I635_RS01045	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I635_RS01065	COG1077	Cell shape determining protein MreB Mrl
I635_RS01075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I635_RS01080	COG2814	Major facilitator Superfamily
I635_RS01085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I635_RS01110	COG1085	galactose-1-phosphate uridylyltransferase
I635_RS01115	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I635_RS01125	COG0629	single-stranded DNA binding
I635_RS01140	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I635_RS01145	COG3250	beta-galactosidase activity
I635_RS01165	COG1349	DNA-binding transcription factor activity
I635_RS01210	COG3409	Peptidoglycan-binding domain 1 protein
I635_RS01210	COG3267	Type II secretory pathway component ExeA
I635_RS01220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I635_RS01225	COG1459	type II secretion system
I635_RS01235	COG2165	general secretion pathway protein
I635_RS01240	COG2165	general secretion pathway protein
I635_RS01270	COG1077	Cell shape determining protein MreB Mrl
I635_RS01275	COG1792	Involved in formation and maintenance of cell shape
I635_RS01280	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I635_RS01290	COG1530	ribonuclease E activity
I635_RS01300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I635_RS01305	COG0312	modulator of DNA gyrase
I635_RS01310	COG3028	Belongs to the UPF0307 family
I635_RS01315	COG0312	modulator of DNA gyrase
I635_RS01325	COG0745	RESPONSE REGULATOR receiver
I635_RS01330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I635_RS01330	COG4191	Histidine kinase
I635_RS01335	COG0297	glycogen (starch) synthase activity
I635_RS01345	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I635_RS01350	COG0596	Alpha beta hydrolase
I635_RS01380	COG5002	protein histidine kinase activity
I635_RS01385	COG0745	RESPONSE REGULATOR receiver
I635_RS01405	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I635_RS01470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I635_RS01470	COG1017	nitric oxide dioxygenase activity
I635_RS01490	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I635_RS01520	COG0375	protein maturation
I635_RS01530	COG0409	Hydrogenase expression formation protein
I635_RS01540	COG0309	Hydrogenase expression formation protein (HypE)
I635_RS01545	COG0789	Transcriptional regulator
I635_RS01550	COG2217	Heavy metal translocating P-type atpase
I635_RS01635	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I635_RS01645	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I635_RS01655	COG0463	Glycosyl transferase, family 2
I635_RS01660	COG0745	RESPONSE REGULATOR receiver
I635_RS01665	COG5002	protein histidine kinase activity
I635_RS01705	COG0789	Transcriptional regulator
I635_RS01710	COG2217	Heavy metal translocating P-type atpase
I635_RS01745	COG0531	amino acid
I635_RS01815	COG2801	Transposase and inactivated derivatives
I635_RS01890	COG1609	Transcriptional regulator
I635_RS01895	COG0673	inositol 2-dehydrogenase activity
I635_RS01905	COG2211	Major facilitator Superfamily
I635_RS01930	COG1454	alcohol dehydrogenase
I635_RS01985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I635_RS02005	COG0089	rRNA binding
I635_RS02015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I635_RS02025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I635_RS02040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I635_RS02045	COG0438	transferase activity, transferring glycosyl groups
I635_RS02055	COG1519	Transferase
I635_RS02090	COG0788	formyltetrahydrofolate deformylase activity
I635_RS02100	COG1643	Atp-dependent helicase
I635_RS02105	COG2951	lytic endotransglycosylase activity
I635_RS02110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I635_RS02120	COG2354	Protein conserved in bacteria
I635_RS02140	COG0004	ammonium transporteR
I635_RS02145	COG0405	Gamma-glutamyltransferase
I635_RS02150	COG2837	iron assimilation
I635_RS02165	COG0540	Belongs to the ATCase OTCase family
I635_RS02190	COG5002	protein histidine kinase activity
I635_RS02190	COG2205	protein histidine kinase activity
I635_RS02190	COG0784	Response regulator, receiver
I635_RS02205	COG3300	MHYT domain
I635_RS02205	COG5001	Diguanylate cyclase
I635_RS02215	COG1012	belongs to the aldehyde dehydrogenase family
I635_RS02225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I635_RS02240	COG0180	Tryptophanyl-tRNA synthetase
I635_RS02245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I635_RS02265	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I635_RS02275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I635_RS02310	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I635_RS02315	COG0281	malic enzyme
I635_RS02325	COG0625	glutathione transferase activity
I635_RS02335	COG0753	catalase activity
I635_RS02350	COG5001	Diguanylate cyclase
I635_RS02350	COG3300	MHYT domain
I635_RS02355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I635_RS02355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I635_RS02365	COG0137	argininosuccinate synthase activity
I635_RS02385	COG1803	Methylglyoxal synthase
I635_RS02395	COG0745	RESPONSE REGULATOR receiver
I635_RS02400	COG2205	protein histidine kinase activity
I635_RS02405	COG2267	carboxylic ester hydrolase activity
I635_RS02410	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I635_RS02420	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I635_RS02430	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I635_RS02435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I635_RS02440	COG4942	peptidase
I635_RS02445	COG2861	carbohydrate metabolic process
I635_RS02470	COG1162	GTPase activity
I635_RS02475	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I635_RS02505	COG0028	Belongs to the TPP enzyme family
I635_RS02525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I635_RS02530	COG0805	protein transport
I635_RS02540	COG0084	hydrolase, TatD family'
I635_RS02545	COG3706	GGDEF domain
I635_RS02545	COG2203	Gaf domain
I635_RS02545	COG4251	negative regulation of phosphorylation
I635_RS02545	COG5001	Diguanylate cyclase
I635_RS02555	COG0248	Ppx GppA phosphatase
I635_RS02560	COG0513	Belongs to the DEAD box helicase family
I635_RS02565	COG3118	belongs to the thioredoxin family
I635_RS02570	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I635_RS02575	COG1473	amidohydrolase
I635_RS02580	COG0784	Response regulator, receiver
I635_RS02580	COG5002	protein histidine kinase activity
I635_RS02585	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I635_RS02590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I635_RS02595	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I635_RS02610	COG0783	Belongs to the Dps family
I635_RS02615	COG2133	pyrroloquinoline quinone binding
I635_RS02620	COG1506	peptidase
I635_RS02620	COG4946	Tricorn protease homolog
I635_RS02620	COG0823	Involved in the tonB-independent uptake of proteins
I635_RS02630	COG3118	belongs to the thioredoxin family
I635_RS02645	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I635_RS02655	COG1012	belongs to the aldehyde dehydrogenase family
I635_RS02675	COG1757	Na H antiporter
I635_RS02690	COG3876	Protein conserved in bacteria
I635_RS02695	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I635_RS02705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I635_RS02715	COG0346	lactoylglutathione lyase activity
I635_RS02740	COG2824	Alkylphosphonate utilization operon protein PhnA
I635_RS02745	COG0454	-acetyltransferase
I635_RS02775	COG3093	addiction module antidote protein HigA
I635_RS02790	COG2026	Addiction module toxin, RelE StbE family
I635_RS02870	COG0183	Belongs to the thiolase family
I635_RS02875	COG1250	3-hydroxyacyl-CoA dehydrogenase
I635_RS02875	COG1024	Enoyl-CoA hydratase
I635_RS02885	COG0006	proline dipeptidase activity
I635_RS02895	COG0142	geranyltranstransferase activity
I635_RS02925	COG1388	LysM domain
I635_RS02925	COG4942	peptidase
I635_RS02930	COG1238	metal cluster binding
I635_RS02940	COG0585	pseudouridine synthase activity
I635_RS02945	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I635_RS02955	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I635_RS02965	COG0840	transmembrane signaling receptor activity
I635_RS03000	COG0494	nUDIX hydrolase
I635_RS03005	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I635_RS03010	COG0730	response to heat
I635_RS03015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I635_RS03020	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I635_RS03055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I635_RS03065	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I635_RS03075	COG1648	precorrin-2 dehydrogenase activity
I635_RS03075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I635_RS03080	COG0513	Belongs to the DEAD box helicase family
I635_RS03095	COG1538	Outer membrane efflux protein
I635_RS03100	COG0494	nUDIX hydrolase
I635_RS03110	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I635_RS03115	COG3150	esterase
I635_RS03120	COG0187	DNA topoisomerase II activity
I635_RS03130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I635_RS03155	COG1509	lysine 2,3-aminomutase activity
I635_RS03160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I635_RS03165	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I635_RS03180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I635_RS03195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I635_RS03210	COG0271	Belongs to the BolA IbaG family
I635_RS03225	COG3707	response regulator
I635_RS03240	COG0659	secondary active sulfate transmembrane transporter activity
I635_RS03245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I635_RS03255	COG0243	molybdopterin cofactor binding
I635_RS03260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I635_RS03260	COG1648	precorrin-2 dehydrogenase activity
I635_RS03265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I635_RS03275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I635_RS03275	COG1116	anion transmembrane transporter activity
I635_RS03285	COG1116	anion transmembrane transporter activity
I635_RS03300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I635_RS03305	COG4206	TonB-dependent receptor
I635_RS03315	COG0348	domain, Protein
I635_RS03330	COG1960	acyl-CoA dehydrogenase activity
I635_RS03335	COG1028	Short-chain dehydrogenase reductase Sdr
I635_RS03345	COG4948	Mandelate Racemase Muconate Lactonizing
I635_RS03360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_RS03365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I635_RS03390	COG0358	DNA primase activity
I635_RS03415	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I635_RS03420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I635_RS03435	COG0537	adenosine 5'-monophosphoramidase activity
I635_RS03450	COG3135	benzoate transporter
I635_RS03455	COG1396	sequence-specific DNA binding
I635_RS03460	COG2974	May be involved in recombination
I635_RS03465	COG4191	Histidine kinase
I635_RS03465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I635_RS03470	COG0745	RESPONSE REGULATOR receiver
I635_RS03475	COG5002	protein histidine kinase activity
I635_RS03500	COG0811	peptide transport
I635_RS03505	COG0811	peptide transport
I635_RS03510	COG0848	biopolymer transport protein
I635_RS03515	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I635_RS03525	COG3437	response regulator, receiver
I635_RS03545	COG2133	pyrroloquinoline quinone binding
I635_RS03555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I635_RS03580	COG0527	aspartate kinase activity
I635_RS03585	COG0840	transmembrane signaling receptor activity
I635_RS03590	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I635_RS03595	COG2967	ApaG domain
I635_RS03605	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I635_RS03610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I635_RS03615	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I635_RS03620	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I635_RS03630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I635_RS03650	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I635_RS03665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I635_RS03670	COG3956	TIGRFAM MazG family protein
I635_RS03695	COG1028	Short-chain dehydrogenase reductase Sdr
I635_RS03705	COG0318	PFAM AMP-dependent synthetase and ligase
I635_RS03715	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I635_RS03725	COG0463	Glycosyl transferase, family 2
I635_RS03745	COG0642	Histidine kinase
I635_RS03765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I635_RS03770	COG0723	plastoquinol--plastocyanin reductase activity
I635_RS03775	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I635_RS03780	COG2857	Cytochrome c1
I635_RS03785	COG0625	glutathione transferase activity
I635_RS03790	COG2969	positive regulation of protein catabolic process
I635_RS03795	COG2239	Acts as a magnesium transporter
I635_RS03800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I635_RS03820	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I635_RS03825	COG1137	ATPase activity
I635_RS03830	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I635_RS03840	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I635_RS03855	COG1127	ABC transporter
I635_RS03860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I635_RS03865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I635_RS03870	COG2854	intermembrane phospholipid transfer
I635_RS03880	COG5007	Belongs to the BolA IbaG family
I635_RS03890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I635_RS03895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I635_RS03905	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I635_RS03940	COG4771	TonB-dependent receptor
I635_RS03945	COG0697	spore germination
I635_RS03955	COG0784	Response regulator, receiver
I635_RS03955	COG2205	protein histidine kinase activity
I635_RS03980	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I635_RS03990	COG0126	phosphoglycerate kinase activity
I635_RS03995	COG3588	fructose-bisphosphate aldolase
I635_RS04005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_RS04015	COG1538	Outer membrane efflux protein
I635_RS04020	COG4946	Tricorn protease homolog
I635_RS04020	COG1506	peptidase
I635_RS04020	COG0823	Involved in the tonB-independent uptake of proteins
I635_RS04025	COG0248	Ppx GppA phosphatase
I635_RS04030	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I635_RS04040	COG0573	inorganic phosphate transmembrane transporter activity
I635_RS04050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I635_RS04060	COG0306	phosphate transporter
I635_RS04070	COG0583	DNA-binding transcription factor activity
I635_RS04080	COG1272	protein, Hemolysin III
I635_RS04085	COG1846	Transcriptional regulator
I635_RS04090	COG1764	response to oxidative stress
I635_RS04105	COG1739	Uncharacterized protein family UPF0029
I635_RS04125	COG0420	3'-5' exonuclease activity
I635_RS04130	COG0419	ATPase involved in DNA repair
I635_RS04140	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I635_RS04155	COG2188	Transcriptional regulator
I635_RS04160	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I635_RS04165	COG2986	histidine ammonia-lyase
I635_RS04190	COG0488	(ABC) transporter
I635_RS04210	COG0668	transmembrane transport
I635_RS04245	COG0582	viral genome integration into host DNA
I635_RS04250	COG4372	Transposase
I635_RS04300	COG1484	DNA-dependent DNA replication
I635_RS04310	COG2801	Transposase and inactivated derivatives
I635_RS04320	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I635_RS04340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I635_RS04390	COG1346	cytolysis
I635_RS04420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I635_RS04430	COG0513	Belongs to the DEAD box helicase family
I635_RS04440	COG3267	Type II secretory pathway component ExeA
I635_RS04440	COG3409	Peptidoglycan-binding domain 1 protein
I635_RS04455	COG0066	3-isopropylmalate dehydratase activity
I635_RS04465	COG0473	3-isopropylmalate dehydrogenase activity
I635_RS04470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I635_RS04490	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I635_RS04505	COG4555	ABC transporter
I635_RS04510	COG1668	transmembrane transport
I635_RS04525	COG4133	protoheme IX ABC transporter activity
I635_RS04530	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I635_RS04535	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I635_RS04540	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I635_RS04550	COG1138	Cytochrome C-type biogenesis protein
I635_RS04555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I635_RS04570	COG2853	Lipoprotein
I635_RS04575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I635_RS04615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I635_RS04630	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I635_RS04635	COG1596	polysaccharide export
I635_RS04635	COG1555	photosystem II stabilization
I635_RS04640	COG0473	3-isopropylmalate dehydrogenase activity
I635_RS04655	COG1611	Belongs to the LOG family
I635_RS04665	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I635_RS04665	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I635_RS04720	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I635_RS04725	COG0024	Methionine aminopeptidase
I635_RS04730	COG0052	Belongs to the universal ribosomal protein uS2 family
I635_RS04740	COG0528	UMP kinase activity
I635_RS04755	COG0575	Belongs to the CDS family
I635_RS04780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I635_RS04785	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I635_RS04800	COG0587	DNA-directed DNA polymerase activity
I635_RS04805	COG0825	malonyl-CoA metabolic process
I635_RS04810	COG0037	tRNA processing
I635_RS04840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I635_RS04840	COG0047	phosphoribosylformylglycinamidine synthase activity
I635_RS04845	COG2840	Smr protein MutS2
I635_RS04875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_RS04880	COG2197	response regulator
I635_RS04915	COG0835	chemotaxis
I635_RS04915	COG0784	Response regulator, receiver
I635_RS04920	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I635_RS04925	COG1815	bacterial-type flagellum-dependent cell motility
I635_RS04945	COG4787	bacterial-type flagellum-dependent cell motility
I635_RS04965	COG3951	Flagellar rod assembly protein muramidase FlgJ
I635_RS04965	COG1705	Flagellar rod assembly protein muramidase FlgJ
I635_RS04970	COG1256	bacterial-type flagellum assembly
I635_RS04985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I635_RS04990	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I635_RS04995	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I635_RS05000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I635_RS05015	COG1516	flagellar protein fliS
I635_RS05030	COG1086	Polysaccharide biosynthesis protein
I635_RS05035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I635_RS05045	COG2089	acid synthase
I635_RS05060	COG1028	Short-chain dehydrogenase reductase Sdr
I635_RS05110	COG1660	Displays ATPase and GTPase activities
I635_RS05115	COG1216	Glycosyl transferase, family 2
I635_RS05130	COG1083	cytidylyl-transferase
I635_RS05155	COG1677	Flagellar hook-basal body complex protein FliE
I635_RS05160	COG1766	The M ring may be actively involved in energy transduction
I635_RS05165	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I635_RS05215	COG1987	bacterial-type flagellum assembly
I635_RS05230	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I635_RS05255	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I635_RS05260	COG0784	Response regulator, receiver
I635_RS05260	COG0643	Histidine kinase
I635_RS05260	COG2198	Histidine kinase
I635_RS05270	COG1192	Involved in chromosome partitioning
I635_RS05280	COG0835	chemotaxis
I635_RS05295	COG0646	methionine synthase
I635_RS05295	COG1410	methionine synthase
I635_RS05300	COG0646	methionine synthase
I635_RS05300	COG1410	methionine synthase
I635_RS05310	COG3123	guanosine phosphorylase activity
I635_RS05315	COG0583	DNA-binding transcription factor activity
I635_RS05320	COG0583	DNA-binding transcription factor activity
I635_RS05330	COG0659	secondary active sulfate transmembrane transporter activity
I635_RS05345	COG3590	peptidase
I635_RS05355	COG2137	regulation of response to DNA damage stimulus
I635_RS05360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I635_RS05390	COG5016	pyruvate
I635_RS05390	COG0511	ligase activity, forming carbon-carbon bonds
I635_RS05395	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I635_RS05400	COG4172	Belongs to the ABC transporter superfamily
I635_RS05410	COG4171	peptide transport system, permease
I635_RS05415	COG4168	peptide transport system, permease
I635_RS05420	COG0747	negative chemotaxis
I635_RS05425	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I635_RS05430	COG1842	Phage shock protein A
I635_RS05460	COG0625	glutathione transferase activity
I635_RS05465	COG1522	sequence-specific DNA binding
I635_RS05525	COG0811	peptide transport
I635_RS05530	COG0811	peptide transport
I635_RS05535	COG0848	biopolymer transport protein
I635_RS05550	COG1444	tRNA N-acetyltransferase activity
I635_RS05590	COG0456	acetyltransferase
I635_RS05605	COG0583	DNA-binding transcription factor activity
I635_RS05610	COG2814	Major facilitator Superfamily
I635_RS05615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I635_RS05620	COG0656	L-ascorbic acid biosynthetic process
I635_RS05640	COG1846	Transcriptional regulator
I635_RS05650	COG3620	sequence-specific DNA binding
I635_RS05655	COG3550	peptidyl-serine autophosphorylation
I635_RS05690	COG0668	transmembrane transport
I635_RS05700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I635_RS05720	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I635_RS05835	COG0789	Transcriptional regulator
I635_RS05850	COG0789	Transcriptional regulator
I635_RS05855	COG0640	Transcriptional regulator
I635_RS05865	COG1230	cation diffusion facilitator family transporter
I635_RS05900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I635_RS05915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I635_RS05930	COG0681	Belongs to the peptidase S26 family
I635_RS05950	COG1074	ATP-dependent DNA helicase activity
I635_RS05960	COG1404	Belongs to the peptidase S8 family
I635_RS05965	COG0464	growth
I635_RS05985	COG0629	single-stranded DNA binding
I635_RS06000	COG0714	Associated with various cellular activities
I635_RS06025	COG2003	Belongs to the UPF0758 family
I635_RS06045	COG0583	DNA-binding transcription factor activity
I635_RS06135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I635_RS06185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I635_RS06190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I635_RS06195	COG0564	pseudouridine synthase activity
I635_RS06205	COG0612	Peptidase, M16
I635_RS06210	COG2918	glutathione biosynthetic process
I635_RS06230	COG2840	Smr protein MutS2
I635_RS06235	COG2890	protein-(glutamine-N5) methyltransferase activity
I635_RS06250	COG2719	SpoVR family
I635_RS06255	COG2718	Belongs to the UPF0229 family
I635_RS06260	COG2766	serine protein kinase
I635_RS06265	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I635_RS06270	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I635_RS06275	COG4771	TonB-dependent receptor
I635_RS06300	COG0450	alkyl hydroperoxide reductase
I635_RS06305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I635_RS06310	COG2885	chlorophyll binding
I635_RS06315	COG0584	glycerophosphoryl diester phosphodiesterase
I635_RS06320	COG0346	lactoylglutathione lyase activity
I635_RS06325	COG1278	Cold shock
I635_RS06340	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I635_RS06345	COG4660	Part of a membrane complex involved in electron transport
I635_RS06350	COG4659	FMN binding
I635_RS06355	COG4658	electron transport chain
I635_RS06360	COG4656	Part of a membrane complex involved in electron transport
I635_RS06365	COG2878	Part of a membrane complex involved in electron transport
I635_RS06370	COG4657	Part of a membrane complex involved in electron transport
I635_RS06385	COG0534	Mate efflux family protein
I635_RS06390	COG0556	nucleotide-excision repair
I635_RS06405	COG0602	queuosine metabolic process
I635_RS06415	COG0367	asparagine synthase
I635_RS06440	COG3273	potassium ion transport
I635_RS06440	COG0471	metal ion transport
I635_RS06455	COG0529	Catalyzes the synthesis of activated sulfate
I635_RS06460	COG0175	sulfate reduction
I635_RS06465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I635_RS06470	COG3706	GGDEF domain
I635_RS06495	COG2304	oxidoreductase activity
I635_RS06515	COG0714	Associated with various cellular activities
I635_RS06525	COG1250	3-hydroxyacyl-CoA dehydrogenase
I635_RS06525	COG1024	Enoyl-CoA hydratase
I635_RS06540	COG1025	Belongs to the peptidase M16 family
I635_RS06545	COG2062	phosphohistidine phosphatase, SixA
I635_RS06555	COG4536	flavin adenine dinucleotide binding
I635_RS06560	COG4137	Cytochrome C assembly protein
I635_RS06565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I635_RS06610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_RS06615	COG1132	(ABC) transporter
I635_RS06630	COG0228	four-way junction DNA binding
I635_RS06635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I635_RS06640	COG0336	Belongs to the RNA methyltransferase TrmD family
I635_RS06645	COG0335	large ribosomal subunit rRNA binding
I635_RS06650	COG2860	membrane
I635_RS06660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I635_RS06665	COG0287	Prephenate dehydrogenase
I635_RS06665	COG1605	Chorismate mutase
I635_RS06670	COG1605	Chorismate mutase
I635_RS06670	COG0077	Prephenate dehydratase
I635_RS06675	COG0745	RESPONSE REGULATOR receiver
I635_RS06680	COG0023	Translation Initiation Factor
I635_RS06710	COG2205	protein histidine kinase activity
I635_RS06720	COG2204	response regulator
I635_RS06740	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I635_RS06745	COG0494	nUDIX hydrolase
I635_RS06750	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I635_RS06755	COG0632	four-way junction helicase activity
I635_RS06760	COG2255	four-way junction helicase activity
I635_RS06765	COG0824	Thioesterase
I635_RS06770	COG0811	peptide transport
I635_RS06785	COG0823	Involved in the tonB-independent uptake of proteins
I635_RS06790	COG2885	chlorophyll binding
I635_RS06795	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I635_RS06820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I635_RS06840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I635_RS06855	COG4667	esterase of the alpha-beta hydrolase superfamily
I635_RS06860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I635_RS06870	COG0784	Response regulator, receiver
I635_RS06870	COG2205	protein histidine kinase activity
I635_RS06890	COG3038	cytochrome b561
I635_RS06910	COG0583	DNA-binding transcription factor activity
I635_RS06915	COG1451	nucleotide metabolic process
I635_RS06925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I635_RS06935	COG1309	transcriptional regulator
I635_RS06940	COG4774	siderophore transport
I635_RS06960	COG3706	GGDEF domain
I635_RS06970	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I635_RS06970	COG3008	intermembrane lipid transfer
I635_RS06975	COG2995	paraquat-inducible protein a
I635_RS06990	COG0017	Asparaginyl-tRNA synthetase
I635_RS07005	COG0189	ligase activity
I635_RS07035	COG0156	8-amino-7-oxononanoate synthase activity
I635_RS07040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I635_RS07050	COG3340	Belongs to the peptidase S51 family
I635_RS07055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I635_RS07060	COG4139	cobalamin transport
I635_RS07065	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I635_RS07070	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I635_RS07085	COG5265	(ABC) transporter
I635_RS07090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I635_RS07100	COG0745	RESPONSE REGULATOR receiver
I635_RS07110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I635_RS07150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I635_RS07165	COG2755	lipolytic protein G-D-S-L family
I635_RS07170	COG4181	ATPase activity
I635_RS07175	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I635_RS07180	COG1090	epimerase
I635_RS07185	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I635_RS07190	COG0628	permease
I635_RS07215	COG2350	Protein conserved in bacteria
I635_RS07220	COG0159	tryptophan synthase activity
I635_RS07230	COG0134	indole-3-glycerol-phosphate synthase activity
I635_RS07230	COG0135	phosphoribosylanthranilate isomerase activity
I635_RS07235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I635_RS07245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I635_RS07250	COG0613	PHP domain protein
I635_RS07255	COG0009	L-threonylcarbamoyladenylate synthase
I635_RS07265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I635_RS07275	COG0656	L-ascorbic acid biosynthetic process
I635_RS07280	COG0110	maltose O-acetyltransferase activity
I635_RS07290	COG2733	membrane
I635_RS07310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_RS07315	COG0500	methyltransferase
I635_RS07320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I635_RS07325	COG0497	DNA recombination
I635_RS07330	COG0783	Belongs to the Dps family
I635_RS07335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I635_RS07340	COG1454	alcohol dehydrogenase
I635_RS07345	COG1028	Short-chain dehydrogenase reductase Sdr
I635_RS07355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I635_RS07360	COG2610	gluconate transmembrane transporter activity
I635_RS07365	COG4771	TonB-dependent receptor
I635_RS07375	COG0784	Response regulator, receiver
I635_RS07375	COG2205	protein histidine kinase activity
I635_RS07375	COG2198	Histidine kinase
I635_RS07380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I635_RS07390	COG0484	heat shock protein binding
I635_RS07395	COG3909	cytochrome
I635_RS07400	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I635_RS07415	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I635_RS07420	COG0505	Belongs to the CarA family
I635_RS07425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I635_RS07430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I635_RS07455	COG0857	belongs to the CobB CobQ family
I635_RS07455	COG0280	phosphate acetyltransferase
I635_RS07470	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I635_RS07475	COG4535	Mg2 and Co2 transporter CorC
I635_RS07485	COG1702	phosphate starvation-inducible protein PhoH
I635_RS07495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I635_RS07525	COG1607	acyl-coa hydrolase
I635_RS07530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I635_RS07540	COG1115	amino acid carrier protein
I635_RS07580	COG0012	GTP binding
I635_RS07595	COG1064	alcohol dehydrogenase
I635_RS07610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I635_RS07620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I635_RS07625	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I635_RS07630	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I635_RS07640	COG2890	protein-(glutamine-N5) methyltransferase activity
I635_RS07645	COG3437	response regulator, receiver
I635_RS07645	COG0784	Response regulator, receiver
I635_RS07655	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I635_RS07665	COG0583	DNA-binding transcription factor activity
I635_RS07675	COG2363	Small membrane protein
I635_RS07690	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I635_RS07695	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I635_RS07700	COG0515	serine threonine protein kinase
I635_RS07705	COG2116	formate transmembrane transporter activity
I635_RS07720	COG0714	Associated with various cellular activities
I635_RS07725	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I635_RS07730	COG0033	Phosphoglucomutase
I635_RS07735	COG0058	SHG alpha-glucan phosphorylase activity
I635_RS07745	COG2988	succinylglutamate desuccinylase activity
I635_RS07780	COG1393	Belongs to the ArsC family
I635_RS07805	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I635_RS07835	COG3300	MHYT domain
I635_RS07835	COG5001	Diguanylate cyclase
I635_RS07860	COG2249	NAD(P)H dehydrogenase (quinone) activity
I635_RS07880	COG1733	regulation of RNA biosynthetic process
I635_RS07885	COG5002	protein histidine kinase activity
I635_RS07885	COG5001	Diguanylate cyclase
I635_RS07885	COG3447	MASE1 domain protein
I635_RS07895	COG0402	S-adenosylhomocysteine deaminase activity
I635_RS07900	COG2351	hydroxyisourate hydrolase activity
I635_RS07915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I635_RS07930	COG1309	transcriptional regulator
I635_RS07945	COG2252	PERMEase
I635_RS07950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I635_RS07965	COG4251	negative regulation of phosphorylation
I635_RS07965	COG2203	Gaf domain
I635_RS07965	COG3706	GGDEF domain
I635_RS07965	COG5001	Diguanylate cyclase
I635_RS07970	COG5001	Diguanylate cyclase
I635_RS07970	COG4251	negative regulation of phosphorylation
I635_RS07970	COG2203	Gaf domain
I635_RS07970	COG3706	GGDEF domain
I635_RS07975	COG2205	protein histidine kinase activity
I635_RS07975	COG0784	Response regulator, receiver
I635_RS07990	COG2233	PERMEase
I635_RS08005	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I635_RS08010	COG0730	response to heat
I635_RS08050	COG1028	Short-chain dehydrogenase reductase Sdr
I635_RS08055	COG3001	Fructosamine kinase
I635_RS08065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I635_RS08080	COG0662	Cupin 2, conserved barrel domain protein
I635_RS08080	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I635_RS08085	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I635_RS08095	COG1596	polysaccharide export
I635_RS08100	COG0489	protein tyrosine kinase activity
I635_RS08105	COG4464	protein tyrosine phosphatase activity
I635_RS08175	COG1215	transferase activity, transferring glycosyl groups
I635_RS08180	COG0438	transferase activity, transferring glycosyl groups
I635_RS08190	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I635_RS08210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I635_RS08210	COG0072	phenylalanine-tRNA ligase activity
I635_RS08225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I635_RS08235	COG1472	Belongs to the glycosyl hydrolase 3 family
I635_RS08240	COG2096	Adenosyltransferase
I635_RS08250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I635_RS08260	COG4591	ABC-type transport system involved in lipoprotein release permease component
I635_RS08285	COG0708	Exodeoxyribonuclease III
I635_RS08320	COG2814	Major facilitator Superfamily
I635_RS08355	COG4770	biotin carboxylase activity
I635_RS08360	COG1024	Enoyl-CoA hydratase
I635_RS08365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I635_RS08370	COG1960	acyl-CoA dehydrogenase activity
I635_RS08375	COG0789	Transcriptional regulator
I635_RS08380	COG0183	Belongs to the thiolase family
I635_RS08395	COG3706	GGDEF domain
I635_RS08405	COG2925	Exonuclease
I635_RS08410	COG0582	viral genome integration into host DNA
I635_RS08450	COG0531	amino acid
I635_RS08450	COG1674	ftsk spoiiie
I635_RS08490	COG2197	response regulator
I635_RS08505	COG3617	BRO family, N-terminal domain
I635_RS08575	COG0305	Participates in initiation and elongation during chromosome replication
I635_RS08665	COG5484	DNA packaging
I635_RS08665	COG3728	DNA packaging
I635_RS08810	COG1643	Atp-dependent helicase
I635_RS08830	COG0604	alcohol dehydrogenase
I635_RS08830	COG3321	synthase
I635_RS08835	COG0328	RNA-DNA hybrid ribonuclease activity
I635_RS08840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I635_RS08870	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I635_RS08875	COG1136	(ABC) transporter
I635_RS08880	COG4591	ABC-type transport system involved in lipoprotein release permease component
I635_RS08895	COG3724	N-succinylarginine dihydrolase activity
I635_RS08905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I635_RS08920	COG0746	molybdenum cofactor guanylyltransferase activity
I635_RS08925	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I635_RS08930	COG0243	molybdopterin cofactor binding
I635_RS08935	COG2153	protein acetylation
I635_RS08950	COG1530	ribonuclease E activity
I635_RS08965	COG0424	maF-like protein
I635_RS08970	COG1399	metal-binding, possibly nucleic acid-binding protein
I635_RS08980	COG0416	fatty acid biosynthetic process
I635_RS08985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I635_RS08990	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I635_RS09000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I635_RS09005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I635_RS09015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I635_RS09030	COG0084	hydrolase, TatD family'
I635_RS09040	COG0702	epimerase
I635_RS09065	COG1028	Short-chain dehydrogenase reductase Sdr
I635_RS09070	COG0596	Alpha beta hydrolase
I635_RS09080	COG0183	Belongs to the thiolase family
I635_RS09085	COG1960	acyl-CoA dehydrogenase activity
I635_RS09105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I635_RS09115	COG0246	Mannitol dehydrogenase
I635_RS09135	COG0668	transmembrane transport
I635_RS09140	COG4771	TonB-dependent receptor
I635_RS09165	COG3437	response regulator, receiver
I635_RS09175	COG0195	Participates in both transcription termination and antitermination
I635_RS09190	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I635_RS09205	COG1187	pseudouridine synthase activity
I635_RS09215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I635_RS09215	COG3153	acetyltransferase
I635_RS09290	COG1032	radical SAM domain protein
I635_RS09305	COG4771	TonB-dependent receptor
I635_RS09310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I635_RS09320	COG4134	Bacterial extracellular solute-binding protein
I635_RS09330	COG4136	ATPase activity
I635_RS09335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I635_RS09360	COG4251	negative regulation of phosphorylation
I635_RS09360	COG2203	Gaf domain
I635_RS09360	COG3706	GGDEF domain
I635_RS09360	COG5001	Diguanylate cyclase
I635_RS09390	COG4372	Transposase
I635_RS09400	COG1902	pentaerythritol trinitrate reductase activity
I635_RS09410	COG2867	negative regulation of translational initiation
I635_RS09415	COG2914	Belongs to the UPF0125 (RnfH) family
I635_RS09430	COG4771	TonB-dependent receptor
I635_RS09435	COG0457	Tetratricopeptide repeat
I635_RS09450	COG0574	Belongs to the PEP-utilizing enzyme family
I635_RS09450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I635_RS09485	COG2850	peptidyl-arginine hydroxylation
I635_RS09495	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I635_RS09500	COG2915	High frequency lysogenization protein hflD homolog
I635_RS09505	COG0482	sulfurtransferase activity
I635_RS09510	COG1187	pseudouridine synthase activity
I635_RS09520	COG1278	Cold shock
I635_RS09525	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I635_RS09530	COG0542	response to heat
I635_RS09535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I635_RS09540	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I635_RS09545	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I635_RS09550	COG0492	ferredoxin-NADP+ reductase activity
I635_RS09560	COG3091	SprT-like family
I635_RS09565	COG0616	signal peptide processing
I635_RS09580	COG0778	Nitroreductase
I635_RS09590	COG0252	asparaginase activity
I635_RS09595	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I635_RS09600	COG0321	lipoyl(octanoyl) transferase activity
I635_RS09605	COG2921	Belongs to the UPF0250 family
I635_RS09610	COG1686	Belongs to the peptidase S11 family
I635_RS09615	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I635_RS09620	COG0772	Belongs to the SEDS family
I635_RS09625	COG0768	penicillin binding
I635_RS09630	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I635_RS09635	COG0799	negative regulation of ribosome biogenesis
I635_RS09645	COG1466	dna polymerase III delta subunit
I635_RS09650	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I635_RS09655	COG0495	leucyl-tRNA aminoacylation
I635_RS09670	COG1067	ATP-dependent peptidase activity
I635_RS09675	COG0596	Alpha beta hydrolase
I635_RS09690	COG1534	Rna-binding protein
I635_RS09695	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I635_RS09700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I635_RS09705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I635_RS09710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I635_RS09715	COG0149	triose-phosphate isomerase activity
I635_RS09720	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I635_RS09730	COG5001	Diguanylate cyclase
I635_RS09730	COG3300	MHYT domain
I635_RS09750	COG1803	Methylglyoxal synthase
I635_RS09750	COG1597	lipid kinase activity
I635_RS09760	COG1028	Short-chain dehydrogenase reductase Sdr
I635_RS09765	COG0561	phosphatase activity
I635_RS09780	COG2801	Transposase and inactivated derivatives
I635_RS09790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I635_RS09795	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I635_RS09800	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I635_RS09815	COG1185	polyribonucleotide nucleotidyltransferase activity
I635_RS09840	COG1819	glycosyl
I635_RS09880	COG3547	Transposase (IS116 IS110 IS902 family)
I635_RS09930	COG2801	Transposase and inactivated derivatives
I635_RS10005	COG4372	Transposase
I635_RS10035	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I635_RS10040	COG1196	nuclear chromosome segregation
I635_RS10050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I635_RS10065	COG1132	(ABC) transporter
I635_RS10070	COG1663	tetraacyldisaccharide 4'-kinase activity
I635_RS10105	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I635_RS10110	COG0435	Glutathione S-transferase
I635_RS10115	COG1741	Belongs to the pirin family
I635_RS10120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I635_RS10130	COG0372	Belongs to the citrate synthase family
I635_RS10140	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I635_RS10145	COG1053	succinate dehydrogenase
I635_RS10150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I635_RS10155	COG0567	Dehydrogenase, E1 component
I635_RS10160	COG0508	dehydrogenase complex catalyzes the overall conversion of
I635_RS10195	COG4667	esterase of the alpha-beta hydrolase superfamily
I635_RS10215	COG0366	Alpha amylase catalytic
I635_RS10240	COG1028	Short-chain dehydrogenase reductase Sdr
I635_RS10245	COG2267	carboxylic ester hydrolase activity
I635_RS10255	COG0616	signal peptide processing
I635_RS10275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I635_RS10280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I635_RS10285	COG0386	Belongs to the glutathione peroxidase family
I635_RS10290	COG2084	Dehydrogenase
I635_RS10300	COG1960	acyl-CoA dehydrogenase activity
I635_RS10305	COG1024	Enoyl-CoA hydratase
I635_RS10310	COG2226	methyltransferase
I635_RS10315	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I635_RS10320	COG3083	sulfuric ester hydrolase activity
I635_RS10325	COG3082	Protein of unknown function (DUF1414)
I635_RS10330	COG3081	Nucleoid-associated protein
I635_RS10360	COG3275	phosphorelay sensor kinase activity
I635_RS10365	COG3279	Response regulator of the LytR AlgR family
I635_RS10370	COG0205	6-phosphofructokinase activity
I635_RS10385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I635_RS10400	COG2205	protein histidine kinase activity
I635_RS10400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I635_RS10410	COG1054	Belongs to the UPF0176 family
I635_RS10420	COG0513	Belongs to the DEAD box helicase family
I635_RS10430	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I635_RS10435	COG0583	DNA-binding transcription factor activity
I635_RS10455	COG1760	l-serine dehydratase
I635_RS10480	COG1322	Protein conserved in bacteria
I635_RS10485	COG1404	Belongs to the peptidase S8 family
I635_RS10490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I635_RS10495	COG0022	dehydrogenase e1 component
I635_RS10505	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I635_RS10510	COG0515	serine threonine protein kinase
I635_RS10515	COG1946	Acyl-CoA thioesterase
I635_RS10525	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I635_RS10535	COG1956	GAF domain-containing protein
I635_RS10550	COG0793	Belongs to the peptidase S41A family
I635_RS10555	COG0733	neurotransmitter:sodium symporter activity
I635_RS10560	COG1757	Na H antiporter
I635_RS10565	COG0308	aminopeptidase N
I635_RS10595	COG2902	Dehydrogenase
I635_RS10600	COG0167	dihydroorotate dehydrogenase activity
I635_RS10615	COG0488	(ABC) transporter
I635_RS10625	COG3130	regulation of translation
I635_RS10630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I635_RS10640	COG0415	Belongs to the DNA photolyase family
I635_RS10645	COG0415	Belongs to the DNA photolyase family
I635_RS10650	COG0415	Belongs to the DNA photolyase family
I635_RS10655	COG3046	protein related to deoxyribodipyrimidine photolyase
I635_RS10665	COG4974	Belongs to the 'phage' integrase family
I635_RS10675	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I635_RS10680	COG0589	response to stress
I635_RS10690	COG0069	glutamate synthase activity
I635_RS10705	COG2193	ferroxidase activity
I635_RS10715	COG3278	Belongs to the heme-copper respiratory oxidase family
I635_RS10730	COG2010	Cytochrome c
I635_RS10755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I635_RS10760	COG0589	response to stress
I635_RS10765	COG0037	tRNA processing
I635_RS10770	COG1752	Esterase of the alpha-beta hydrolase superfamily
I635_RS10790	COG1280	lysine exporter protein (LysE YggA)
I635_RS10800	COG2897	thiosulfate sulfurtransferase activity
I635_RS10805	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I635_RS10810	COG3148	PFAM DTW domain containing protein
I635_RS10835	COG0322	excinuclease ABC activity
I635_RS10840	COG2197	response regulator
I635_RS10845	COG0436	Aminotransferase
I635_RS10865	COG2259	Doxx family
I635_RS10870	COG0583	DNA-binding transcription factor activity
I635_RS10885	COG0670	Belongs to the BI1 family
I635_RS10890	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I635_RS10905	COG2920	part of a sulfur-relay system
I635_RS10935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I635_RS10945	COG0531	amino acid
I635_RS10945	COG1674	ftsk spoiiie
I635_RS10955	COG0686	Belongs to the AlaDH PNT family
I635_RS10960	COG0284	orotidine-5'-phosphate decarboxylase activity
I635_RS10965	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I635_RS10980	COG0776	regulation of translation
I635_RS10985	COG0539	negative regulation of cytoplasmic translation
I635_RS10990	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I635_RS10995	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I635_RS11000	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I635_RS11010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I635_RS11015	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I635_RS11020	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I635_RS11025	COG0633	Ferredoxin
I635_RS11055	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I635_RS11060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I635_RS11070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I635_RS11080	COG4783	chaperone-mediated protein folding
I635_RS11090	COG1393	Belongs to the ArsC family
I635_RS11105	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I635_RS11120	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I635_RS11130	COG1960	acyl-CoA dehydrogenase activity
I635_RS11155	COG0572	uridine kinase
I635_RS11160	COG3769	mannosylglycerate metabolic process
I635_RS11165	COG1215	transferase activity, transferring glycosyl groups
I635_RS11170	COG0366	Alpha amylase catalytic
I635_RS11180	COG0303	'Molybdopterin
I635_RS11185	COG0534	Mate efflux family protein
I635_RS11200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I635_RS11205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I635_RS11235	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I635_RS11255	COG3547	Transposase (IS116 IS110 IS902 family)
I635_RS11280	COG0405	Gamma-glutamyltransferase
I635_RS11285	COG1024	Enoyl-CoA hydratase
I635_RS11330	COG1448	Aminotransferase
I635_RS11340	COG1671	Belongs to the UPF0178 family
I635_RS11345	COG1028	Short-chain dehydrogenase reductase Sdr
I635_RS11350	COG1028	Short-chain dehydrogenase reductase Sdr
I635_RS11355	COG1960	acyl-CoA dehydrogenase activity
I635_RS11360	COG2207	Transcriptional regulator
I635_RS11360	COG0662	Cupin 2, conserved barrel domain protein
I635_RS11375	COG3344	reverse transcriptase
I635_RS11380	COG1505	serine-type exopeptidase activity
I635_RS11390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_RS11420	COG0596	Alpha beta hydrolase
I635_RS11430	COG0716	FMN binding
I635_RS11440	COG0735	belongs to the Fur family
I635_RS11450	COG1984	allophanate hydrolase subunit 2
I635_RS11455	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I635_RS11460	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I635_RS11465	COG2996	Protein conserved in bacteria
I635_RS11470	COG1765	OsmC-like protein
I635_RS11475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_RS11485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I635_RS11500	COG0436	Aminotransferase
I635_RS11505	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I635_RS11510	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I635_RS11520	COG2010	Cytochrome c
I635_RS11520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I635_RS11525	COG2080	2 iron, 2 sulfur cluster binding
I635_RS11550	COG1073	alpha beta
I635_RS11555	COG2207	Transcriptional regulator
I635_RS11565	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I635_RS11570	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I635_RS11595	COG3012	SEC-C Motif Domain Protein
I635_RS11600	COG0604	alcohol dehydrogenase
I635_RS11610	COG1960	acyl-CoA dehydrogenase activity
I635_RS11620	COG4771	TonB-dependent receptor
I635_RS11645	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I635_RS11665	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I635_RS11670	COG0315	cyclic pyranopterin monophosphate synthase activity
I635_RS11675	COG0521	Mo-molybdopterin cofactor biosynthetic process
I635_RS11690	COG2161	toxin-antitoxin pair type II binding
I635_RS11695	COG4115	mRNA cleavage
I635_RS11710	COG0436	Aminotransferase
I635_RS11715	COG3268	Saccharopine dehydrogenase
I635_RS11720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I635_RS11735	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I635_RS11740	COG4206	TonB-dependent receptor
I635_RS11750	COG5006	permease, DMT superfamily
I635_RS11765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I635_RS11770	COG1074	ATP-dependent DNA helicase activity
I635_RS11775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I635_RS11790	COG1022	Amp-dependent synthetase and ligase
I635_RS11795	COG5001	Diguanylate cyclase
I635_RS11795	COG2203	Gaf domain
I635_RS11795	COG3706	GGDEF domain
I635_RS11795	COG4251	negative regulation of phosphorylation
I635_RS11815	COG0583	DNA-binding transcription factor activity
I635_RS11830	COG0640	Transcriptional regulator
I635_RS11850	COG2204	response regulator
I635_RS11860	COG4251	negative regulation of phosphorylation
I635_RS11865	COG0784	Response regulator, receiver
I635_RS11870	COG0784	Response regulator, receiver
I635_RS11870	COG2205	protein histidine kinase activity
I635_RS11895	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I635_RS11920	COG3139	Protein of unknown function (DUF1315)
I635_RS11935	COG1115	amino acid carrier protein
I635_RS11940	COG2866	Carboxypeptidase
I635_RS11960	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I635_RS11970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I635_RS11975	COG1640	4-alpha-glucanotransferase
I635_RS11980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I635_RS11985	COG0676	glucose-6-phosphate 1-epimerase activity
I635_RS11990	COG0800	Aldolase
I635_RS12000	COG0129	dihydroxy-acid dehydratase activity
I635_RS12010	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I635_RS12015	COG1737	Transcriptional regulator
I635_RS12020	COG0469	pyruvate kinase activity
I635_RS12035	COG1960	acyl-CoA dehydrogenase activity
I635_RS12055	COG0490	domain, Protein
I635_RS12055	COG0471	metal ion transport
I635_RS12065	COG0800	Aldolase
I635_RS12075	COG0129	dihydroxy-acid dehydratase activity
I635_RS12085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I635_RS12090	COG1737	Transcriptional regulator
I635_RS12095	COG0469	pyruvate kinase activity
I635_RS12100	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I635_RS12120	COG2823	Periplasmic or secreted lipoprotein
I635_RS12150	COG3665	Urea carboxylase-associated protein
I635_RS12180	COG2356	endonuclease I
I635_RS12200	COG0583	DNA-binding transcription factor activity
I635_RS12205	COG1979	alcohol dehydrogenase
I635_RS12220	COG0784	Response regulator, receiver
I635_RS12220	COG3437	response regulator, receiver
I635_RS12320	COG0471	metal ion transport
I635_RS12330	COG0489	protein tyrosine kinase activity
I635_RS12335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I635_RS12335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I635_RS12340	COG0668	transmembrane transport
I635_RS12345	COG2226	methyltransferase
I635_RS12350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I635_RS12355	COG0741	lytic transglycosylase activity
I635_RS12355	COG1388	LysM domain
I635_RS12380	COG0215	cysteine-tRNA ligase activity
I635_RS12385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I635_RS12390	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I635_RS12400	COG2268	Band 7 protein
I635_RS12415	COG1733	regulation of RNA biosynthetic process
I635_RS12420	COG0604	alcohol dehydrogenase
I635_RS12425	COG0753	catalase activity
I635_RS12430	COG0604	alcohol dehydrogenase
I635_RS12435	COG0583	DNA-binding transcription factor activity
I635_RS12470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I635_RS12475	COG1286	toxin biosynthetic process
I635_RS12480	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I635_RS12485	COG0285	dihydrofolate synthase activity
I635_RS12505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I635_RS12510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I635_RS12530	COG3609	addiction module antidote protein, CC2985 family
I635_RS12540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I635_RS12545	COG0318	PFAM AMP-dependent synthetase and ligase
I635_RS12555	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I635_RS12555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I635_RS12590	COG0789	Transcriptional regulator
I635_RS12595	COG0604	alcohol dehydrogenase
I635_RS12620	COG1028	Short-chain dehydrogenase reductase Sdr
I635_RS12625	COG1119	ATPase activity
I635_RS12630	COG2031	fatty acid transporter
I635_RS12635	COG2205	protein histidine kinase activity
I635_RS12635	COG0784	Response regulator, receiver
I635_RS12635	COG5002	protein histidine kinase activity
I635_RS12645	COG0612	Peptidase, M16
I635_RS12660	COG3101	peptidyl-lysine hydroxylation
I635_RS12690	COG1902	pentaerythritol trinitrate reductase activity
I635_RS12690	COG0446	pyridine nucleotide-disulphide oxidoreductase
I635_RS12715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I635_RS12725	COG4399	Belongs to the UPF0754 family
I635_RS12750	COG1770	oligopeptidase
I635_RS12755	COG2186	Transcriptional regulator
I635_RS12765	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I635_RS12770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I635_RS12780	COG2983	Belongs to the UPF0260 family
I635_RS12785	COG0179	Fumarylacetoacetate (FAA) hydrolase
I635_RS12800	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I635_RS12805	COG0318	PFAM AMP-dependent synthetase and ligase
I635_RS12810	COG2267	carboxylic ester hydrolase activity
I635_RS12825	COG1214	PFAM Peptidase M22, glycoprotease
I635_RS12830	COG1199	ATP-dependent helicase activity
I635_RS12880	COG4771	TonB-dependent receptor
I635_RS12890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I635_RS12895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I635_RS12900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I635_RS12905	COG0131	Imidazoleglycerol-phosphate dehydratase
I635_RS12905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I635_RS12910	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I635_RS12940	COG2116	formate transmembrane transporter activity
I635_RS12945	COG0612	Peptidase, M16
I635_RS12975	COG0326	Molecular chaperone. Has ATPase activity
I635_RS12980	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I635_RS13000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I635_RS13005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I635_RS13015	COG3220	belongs to the UPF0276 family
I635_RS13025	COG1136	(ABC) transporter
I635_RS13025	COG0577	efflux transmembrane transporter activity
I635_RS13035	COG4251	negative regulation of phosphorylation
I635_RS13035	COG3706	GGDEF domain
I635_RS13035	COG5001	Diguanylate cyclase
I635_RS13035	COG2203	Gaf domain
I635_RS13065	COG1183	phosphatidylcholine synthase activity
I635_RS13085	COG0277	FAD linked oxidase domain protein
I635_RS13090	COG0542	response to heat
I635_RS13115	COG1595	DNA-templated transcription, initiation
I635_RS13130	COG4221	oxidoreductase activity
I635_RS13145	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I635_RS13155	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I635_RS13165	COG0142	geranyltranstransferase activity
I635_RS13175	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I635_RS13180	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I635_RS13190	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I635_RS13205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I635_RS13205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I635_RS13220	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I635_RS13225	COG0488	(ABC) transporter
I635_RS13235	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I635_RS13245	COG0560	Phosphoserine phosphatase
I635_RS13255	COG0084	hydrolase, TatD family'
I635_RS13270	COG0571	ribonuclease III activity
I635_RS13300	COG1595	DNA-templated transcription, initiation
I635_RS13305	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I635_RS13320	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I635_RS13400	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I635_RS13405	COG1047	Peptidyl-prolyl cis-trans
I635_RS13415	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I635_RS13420	COG0196	riboflavin kinase activity
I635_RS13425	COG0728	peptidoglycan biosynthetic process
I635_RS13430	COG0268	Binds directly to 16S ribosomal RNA
I635_RS13450	COG0385	Bile acid
I635_RS13480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I635_RS13485	COG0776	regulation of translation
I635_RS13490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I635_RS13495	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I635_RS13500	COG0740	serine-type endopeptidase activity
I635_RS13505	COG0544	peptidyl-prolyl cis-trans isomerase activity
I635_RS13560	COG1720	tRNA m6t6A37 methyltransferase activity
I635_RS13570	COG1234	tRNA 3'-trailer cleavage
I635_RS13580	COG0123	including yeast histone deacetylase and acetoin utilization protein
I635_RS13595	COG0517	IMP dehydrogenase activity
I635_RS13595	COG0516	GMP reductase activity
I635_RS13600	COG1570	exodeoxyribonuclease VII activity
I635_RS13620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I635_RS13625	COG2976	Protein conserved in bacteria
I635_RS13650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I635_RS13660	COG2166	iron-sulfur cluster assembly
I635_RS13675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I635_RS13680	COG0719	Fe-S assembly protein
I635_RS13685	COG0396	ATPase activity
I635_RS13690	COG0719	Fe-S assembly protein
I635_RS13695	COG1104	cysteine desulfurase activity
I635_RS13705	COG2072	flavoprotein involved in K transport
I635_RS13710	COG1045	serine acetyltransferase
I635_RS13715	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I635_RS13720	COG0483	inositol monophosphate 1-phosphatase activity
I635_RS13735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I635_RS13740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I635_RS13745	COG1862	Preprotein translocase
I635_RS13750	COG0343	queuine tRNA-ribosyltransferase activity
I635_RS13770	COG1842	Phage shock protein A
I635_RS13775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I635_RS13795	COG0754	glutathionylspermidine amidase activity
I635_RS13825	COG2066	Belongs to the glutaminase family
I635_RS13830	COG1785	Belongs to the alkaline phosphatase family
I635_RS13835	COG0745	RESPONSE REGULATOR receiver
I635_RS13905	COG0438	transferase activity, transferring glycosyl groups
I635_RS13925	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I635_RS13930	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I635_RS13960	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I635_RS13960	COG2755	lipolytic protein G-D-S-L family
I635_RS13965	COG0367	asparagine synthase
I635_RS13970	COG0438	transferase activity, transferring glycosyl groups
I635_RS13980	COG2244	polysaccharide biosynthetic process
I635_RS14010	COG0367	asparagine synthase
I635_RS14045	COG0489	protein tyrosine kinase activity
I635_RS14055	COG3409	Peptidoglycan-binding domain 1 protein
I635_RS14055	COG3267	Type II secretory pathway component ExeA
I635_RS14105	COG1560	Kdo2-lipid A biosynthetic process
I635_RS14120	COG1960	acyl-CoA dehydrogenase activity
I635_RS14135	COG5001	Diguanylate cyclase
I635_RS14135	COG3300	MHYT domain
I635_RS14140	COG1435	thymidine kinase activity
I635_RS14150	COG1609	Transcriptional regulator
I635_RS14155	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I635_RS14180	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I635_RS14185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I635_RS14190	COG1250	3-hydroxyacyl-CoA dehydrogenase
I635_RS14190	COG1024	Enoyl-CoA hydratase
I635_RS14205	COG1012	belongs to the aldehyde dehydrogenase family
I635_RS14225	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I635_RS14250	COG1960	acyl-CoA dehydrogenase activity
I635_RS14280	COG0745	RESPONSE REGULATOR receiver
I635_RS14285	COG2205	protein histidine kinase activity
I635_RS14325	COG2080	2 iron, 2 sulfur cluster binding
I635_RS14330	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I635_RS14335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I635_RS14355	COG1028	Short-chain dehydrogenase reductase Sdr
I635_RS14360	COG4221	oxidoreductase activity
I635_RS14365	COG0693	protein deglycase activity
I635_RS14370	COG1295	ribonuclease BN
I635_RS14410	COG2814	Major facilitator Superfamily
I635_RS14425	COG0514	ATP-dependent DNA helicase (RecQ)
I635_RS14455	COG4251	negative regulation of phosphorylation
I635_RS14460	COG2133	pyrroloquinoline quinone binding
I635_RS14465	COG3609	addiction module antidote protein, CC2985 family
I635_RS14495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I635_RS14500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I635_RS14515	COG0330	HflC and HflK could
I635_RS14605	COG4772	TonB-dependent receptor
I635_RS14650	COG4372	Transposase
I635_RS14665	COG1017	nitric oxide dioxygenase activity
I635_RS14665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I635_RS14670	COG3604	Transcriptional regulator
I635_RS14685	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I635_RS14685	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I635_RS14700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I635_RS14705	COG2971	BadF BadG BcrA BcrD
I635_RS14710	COG0583	DNA-binding transcription factor activity
I635_RS14715	COG1620	l-lactate permease
I635_RS14735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I635_RS14740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I635_RS14745	COG0006	proline dipeptidase activity
I635_RS14755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I635_RS14770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I635_RS14775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I635_RS14780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I635_RS14800	COG3313	Fe-S protein
I635_RS14835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I635_RS14840	COG0508	dehydrogenase complex catalyzes the overall conversion of
I635_RS14845	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I635_RS14860	COG3023	N-Acetylmuramoyl-L-alanine amidase
I635_RS14865	COG3577	Aspartyl protease
I635_RS14870	COG0157	Belongs to the NadC ModD family
I635_RS14880	COG1459	type II secretion system
I635_RS14885	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I635_RS14890	COG0237	dephospho-CoA kinase activity
I635_RS14895	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I635_RS14900	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I635_RS14905	COG3608	succinylglutamate desuccinylase aspartoacylase
I635_RS14910	COG0494	nUDIX hydrolase
I635_RS14920	COG0739	heme binding
I635_RS14925	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I635_RS14930	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I635_RS14935	COG0849	cell division
I635_RS14940	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I635_RS14945	COG1181	Belongs to the D-alanine--D-alanine ligase family
I635_RS14950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I635_RS14960	COG0772	Belongs to the SEDS family
I635_RS14965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I635_RS14975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I635_RS14980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I635_RS14985	COG0768	penicillin binding
I635_RS14990	COG3116	cell division
I635_RS15000	COG2001	Belongs to the MraZ family
I635_RS15040	COG0678	peroxiredoxin activity
I635_RS15040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I635_RS15065	COG2204	response regulator
I635_RS15070	COG2205	protein histidine kinase activity
I635_RS15070	COG0784	Response regulator, receiver
I635_RS15095	COG0668	transmembrane transport
I635_RS15100	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I635_RS15105	COG0189	ligase activity
I635_RS15110	COG1678	Uncharacterized ACR, COG1678
I635_RS15115	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I635_RS15140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I635_RS15145	COG0762	integral membrane protein
I635_RS15155	COG0446	pyridine nucleotide-disulphide oxidoreductase
I635_RS15155	COG1902	pentaerythritol trinitrate reductase activity
I635_RS15170	COG0625	glutathione transferase activity
I635_RS15180	COG1764	response to oxidative stress
I635_RS15185	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I635_RS15200	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I635_RS15210	COG2814	Major facilitator Superfamily
I635_RS15215	COG0724	RNA recognition motif
I635_RS15240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I635_RS15245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I635_RS15250	COG0083	homoserine kinase activity
I635_RS15265	COG0583	DNA-binding transcription factor activity
I635_RS15280	COG0640	Transcriptional regulator
I635_RS15290	COG0431	NADPH-dependent FMN reductase
I635_RS15295	COG0798	PFAM Bile acid sodium symporter
I635_RS15300	COG2201	protein-glutamate methylesterase activity
I635_RS15305	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I635_RS15315	COG0642	Histidine kinase
I635_RS15340	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I635_RS15365	COG1748	Saccharopine dehydrogenase
I635_RS15380	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I635_RS15385	COG3107	peptidoglycan biosynthetic process
I635_RS15395	COG0438	transferase activity, transferring glycosyl groups
I635_RS15405	COG2823	Periplasmic or secreted lipoprotein
I635_RS15425	COG4585	Histidine kinase
I635_RS15430	COG2197	response regulator
I635_RS15445	COG4771	TonB-dependent receptor
I635_RS15455	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I635_RS15460	COG0372	Belongs to the citrate synthase family
I635_RS15465	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I635_RS15470	COG2828	Protein conserved in bacteria
I635_RS15475	COG2199	diguanylate cyclase activity
I635_RS15475	COG2203	Gaf domain
I635_RS15480	COG1940	carbohydrate kinase activity
I635_RS15500	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I635_RS15520	COG0784	Response regulator, receiver
I635_RS15520	COG2198	Histidine kinase
I635_RS15520	COG5002	protein histidine kinase activity
I635_RS15525	COG3023	N-Acetylmuramoyl-L-alanine amidase
I635_RS15530	COG0070	glutamate synthase
I635_RS15530	COG0067	glutamate synthase
I635_RS15530	COG0069	glutamate synthase activity
I635_RS15535	COG0493	'glutamate synthase
I635_RS15550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I635_RS15555	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I635_RS15560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I635_RS15565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I635_RS15580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I635_RS15585	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I635_RS15595	COG4942	peptidase
I635_RS15600	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I635_RS15605	COG0738	Major facilitator superfamily
I635_RS15615	COG1902	pentaerythritol trinitrate reductase activity
I635_RS15635	COG0625	glutathione transferase activity
I635_RS15660	COG2894	cell division
I635_RS15665	COG0850	regulation of cytokinetic process
I635_RS15675	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I635_RS15690	COG1981	membrane
I635_RS15705	COG1914	H( )-stimulated, divalent metal cation uptake system
I635_RS15720	COG1217	gtp-binding protein TYPA
I635_RS15725	COG0174	glutamine synthetase
I635_RS15735	COG3852	Histidine kinase
I635_RS15740	COG2204	response regulator
I635_RS15745	COG3437	response regulator, receiver
I635_RS15785	COG4999	Histidine kinase
I635_RS15785	COG3850	Histidine kinase
I635_RS15785	COG2205	protein histidine kinase activity
I635_RS15785	COG3437	response regulator, receiver
I635_RS15790	COG0525	valine-tRNA ligase activity
I635_RS15795	COG2927	DNA polymerase III (CHI subunit)
I635_RS15800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I635_RS15805	COG0795	lipopolysaccharide-transporting ATPase activity
I635_RS15810	COG0795	lipopolysaccharide-transporting ATPase activity
I635_RS15905	COG4974	Belongs to the 'phage' integrase family
I635_RS15920	COG2856	Zn peptidase
I635_RS16030	COG3250	beta-galactosidase activity
I635_RS16040	COG4948	Mandelate Racemase Muconate Lactonizing
I635_RS16045	COG3661	Belongs to the glycosyl hydrolase 67 family
I635_RS16060	COG2199	diguanylate cyclase activity
I635_RS16060	COG2203	Gaf domain
I635_RS16090	COG0673	inositol 2-dehydrogenase activity
I635_RS16100	COG0628	permease
I635_RS16115	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I635_RS16120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I635_RS16125	COG4558	Periplasmic binding protein
I635_RS16135	COG4206	TonB-dependent receptor
I635_RS16145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I635_RS16175	COG1971	Probably functions as a manganese efflux pump
I635_RS16185	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I635_RS16200	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I635_RS16210	COG0679	Auxin Efflux Carrier
I635_RS16240	COG1131	(ABC) transporter
I635_RS16260	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I635_RS16300	COG2205	protein histidine kinase activity
I635_RS16310	COG0348	domain, Protein
I635_RS16310	COG3901	Regulator of nitric oxide reductase transcription
I635_RS16320	COG2197	response regulator
I635_RS16345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I635_RS16360	COG4771	TonB-dependent receptor
I635_RS16370	COG0583	DNA-binding transcription factor activity
I635_RS16375	COG1304	FMN binding
I635_RS16380	COG0277	FAD linked oxidase domain protein
I635_RS16390	COG1462	curli production assembly transport component CsgG
I635_RS16420	COG2197	response regulator
I635_RS16435	COG0513	Belongs to the DEAD box helicase family
I635_RS16445	COG1294	oxidase, subunit
I635_RS16450	COG1271	oxidase subunit
I635_RS16470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I635_RS16480	COG2124	cytochrome p450
I635_RS16500	COG2203	Gaf domain
I635_RS16500	COG2199	diguanylate cyclase activity
I635_RS16550	COG2337	Toxic component of a toxin-antitoxin (TA) module
I635_RS16580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I635_RS16585	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I635_RS16585	COG2010	Cytochrome c
I635_RS16615	COG1271	oxidase subunit
I635_RS16620	COG1294	oxidase, subunit
I635_RS16645	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I635_RS16645	COG3264	Mechanosensitive ion channel
I635_RS16685	COG0730	response to heat
I635_RS16690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I635_RS16705	COG4191	Histidine kinase
I635_RS16715	COG0417	DNA replication proofreading
I635_RS16725	COG0318	PFAM AMP-dependent synthetase and ligase
I635_RS16770	COG1309	transcriptional regulator
I635_RS16780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I635_RS16790	COG1573	uracil-dna glycosylase
I635_RS16795	COG5001	Diguanylate cyclase
I635_RS16795	COG3300	MHYT domain
I635_RS16815	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I635_RS16835	COG1983	PspC domain protein
I635_RS16840	COG1842	Phage shock protein A
I635_RS16850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I635_RS16875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I635_RS16885	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I635_RS16890	COG0204	Acyl-transferase
I635_RS16895	COG0204	Acyl-transferase
I635_RS16900	COG0668	transmembrane transport
I635_RS16915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I635_RS16920	COG0733	neurotransmitter:sodium symporter activity
I635_RS16935	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I635_RS16960	COG0848	biopolymer transport protein
I635_RS16975	COG0457	Tetratricopeptide repeat
I635_RS16980	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I635_RS16990	COG1215	transferase activity, transferring glycosyl groups
I635_RS17005	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I635_RS17010	COG0702	epimerase
I635_RS17025	COG5002	protein histidine kinase activity
I635_RS17025	COG5001	Diguanylate cyclase
I635_RS17035	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I635_RS17045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I635_RS17055	COG0583	DNA-binding transcription factor activity
I635_RS17060	COG0121	glutamine amidotransferase
I635_RS17065	COG4682	membrane
I635_RS17085	COG1953	Uracil, thiamine, allantoin
I635_RS17090	COG4771	TonB-dependent receptor
I635_RS17100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I635_RS17105	COG0778	Nitroreductase
I635_RS17110	COG0596	Alpha beta hydrolase
I635_RS17115	COG0251	oxidation-reduction process
I635_RS17120	COG1335	isochorismatase
I635_RS17125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I635_RS17130	COG1309	transcriptional regulator
I635_RS17145	COG4628	conserved protein (DUF2132)
I635_RS17150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I635_RS17160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I635_RS17170	COG1477	protein flavinylation
I635_RS17175	COG2871	sodium ion transport
I635_RS17180	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I635_RS17185	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I635_RS17190	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I635_RS17195	COG1805	sodium ion transport
I635_RS17200	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I635_RS17205	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I635_RS17210	COG0545	Peptidyl-prolyl cis-trans isomerase
I635_RS17215	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I635_RS17230	COG0039	L-malate dehydrogenase activity
I635_RS17235	COG1438	arginine binding
I635_RS17260	COG0572	uridine kinase
I635_RS17265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I635_RS17290	COG2176	DNA-directed DNA polymerase activity
I635_RS17295	COG0517	IMP dehydrogenase activity
I635_RS17295	COG1125	glycine betaine transport
I635_RS17300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I635_RS17310	COG2205	protein histidine kinase activity
I635_RS17320	COG0189	ligase activity
I635_RS17330	COG0189	ligase activity
I635_RS17330	COG4067	protein conserved in archaea
I635_RS17345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I635_RS17355	COG1283	sodium-dependent phosphate transmembrane transporter activity
I635_RS17360	COG0667	Aldo Keto reductase
I635_RS17375	COG5001	Diguanylate cyclase
I635_RS17410	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I635_RS17420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I635_RS17425	COG0840	transmembrane signaling receptor activity
I635_RS17460	COG2274	protein secretion by the type I secretion system
I635_RS17465	COG0583	DNA-binding transcription factor activity
I635_RS17490	COG1216	Glycosyl transferase, family 2
I635_RS17490	COG0438	transferase activity, transferring glycosyl groups
I635_RS17530	COG0457	Tetratricopeptide repeat
I635_RS17565	COG0463	Glycosyl transferase, family 2
I635_RS17565	COG1216	Glycosyl transferase, family 2
I635_RS17655	COG4372	Transposase
I635_RS17675	COG4372	Transposase
I635_RS17725	COG2161	toxin-antitoxin pair type II binding
I635_RS17735	COG0202	RNA polymerase activity
I635_RS17760	COG0201	protein transport
I635_RS17780	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I635_RS17815	COG5002	protein histidine kinase activity
I635_RS17815	COG0784	Response regulator, receiver
I635_RS17835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I635_RS17840	COG0557	exoribonuclease II activity
I635_RS17870	COG4771	TonB-dependent receptor
I635_RS17885	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I635_RS17900	COG0543	2 iron, 2 sulfur cluster binding
I635_RS17915	COG2234	aminopeptidase activity
I635_RS17925	COG4251	negative regulation of phosphorylation
I635_RS17935	COG1271	oxidase subunit
I635_RS17940	COG1294	oxidase, subunit
I635_RS17945	COG1522	sequence-specific DNA binding
I635_RS17955	COG1278	Cold shock
I635_RS17960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I635_RS17980	COG0339	signal peptide processing
I635_RS17985	COG2201	protein-glutamate methylesterase activity
I635_RS17995	COG3852	Histidine kinase
I635_RS18005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I635_RS18010	COG0243	molybdopterin cofactor binding
I635_RS18015	COG4946	Tricorn protease homolog
I635_RS18015	COG0823	Involved in the tonB-independent uptake of proteins
I635_RS18015	COG1506	peptidase
I635_RS18060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_RS18070	COG2197	response regulator
I635_RS18080	COG0189	ligase activity
I635_RS18100	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I635_RS18105	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I635_RS18110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I635_RS18125	COG0281	malic enzyme
I635_RS18135	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I635_RS18165	COG0456	acetyltransferase
I635_RS18175	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I635_RS18180	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I635_RS18185	COG2177	Part of the ABC transporter FtsEX involved in
I635_RS18190	COG2884	Cell division ATP-binding protein ftsE
I635_RS18195	COG0552	protein localization to endoplasmic reticulum
I635_RS18205	COG0742	ribosomal rna small subunit methyltransferase
I635_RS18215	COG2095	MarC family integral membrane protein
I635_RS18235	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I635_RS18240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I635_RS18245	COG0617	tRNA 3'-terminal CCA addition
I635_RS18250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I635_RS18265	COG0076	glutamate decarboxylase activity
I635_RS18280	COG0842	Transport permease protein
I635_RS18285	COG1131	(ABC) transporter
I635_RS18290	COG0745	RESPONSE REGULATOR receiver
I635_RS18295	COG2205	protein histidine kinase activity
I635_RS18300	COG4774	siderophore transport
I635_RS18320	COG1253	flavin adenine dinucleotide binding
I635_RS18340	COG0657	acetylesterase activity
I635_RS18355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I635_RS18360	COG0049	tRNA binding
I635_RS18365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I635_RS18370	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I635_RS18375	COG0085	RNA polymerase activity
I635_RS18380	COG0222	ribosome binding
I635_RS18385	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I635_RS18390	COG0081	regulation of translation
I635_RS18395	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I635_RS18415	COG0250	Participates in transcription elongation, termination and antitermination
I635_RS18420	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I635_RS18430	COG1132	(ABC) transporter
I635_RS18435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I635_RS18440	COG3590	peptidase
I635_RS18450	COG0513	Belongs to the DEAD box helicase family
I635_RS18455	COG0418	dihydroorotase activity
I635_RS18460	COG3040	lipid binding
I635_RS18465	COG4989	oxidoreductase activity
I635_RS18470	COG0346	lactoylglutathione lyase activity
I635_RS18475	COG0668	transmembrane transport
I635_RS18495	COG0302	gtp cyclohydrolase
I635_RS18505	COG2957	Belongs to the agmatine deiminase family
I635_RS18510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I635_RS18525	COG1201	RNA secondary structure unwinding
I635_RS18535	COG1793	dna ligase
I635_RS18540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I635_RS18545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I635_RS18555	COG1410	methionine synthase
I635_RS18555	COG0646	methionine synthase
I635_RS18560	COG0625	glutathione transferase activity
I635_RS18565	COG0625	glutathione transferase activity
I635_RS18575	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I635_RS18590	COG1012	belongs to the aldehyde dehydrogenase family
I635_RS18595	COG0028	Belongs to the TPP enzyme family
I635_RS18605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I635_RS18610	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I635_RS18615	COG0330	HflC and HflK could
I635_RS18620	COG0330	HflC and HflK could
I635_RS18625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I635_RS18630	COG1923	regulation of RNA biosynthetic process
I635_RS18635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I635_RS18650	COG0802	atpase or kinase
I635_RS18655	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I635_RS18655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I635_RS18660	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I635_RS18680	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I635_RS18685	COG0735	belongs to the Fur family
I635_RS18705	COG0305	Participates in initiation and elongation during chromosome replication
I635_RS18730	COG2258	MOSC domain
I635_RS18760	COG2205	protein histidine kinase activity
I635_RS18780	COG0840	transmembrane signaling receptor activity
I635_RS18785	COG5002	protein histidine kinase activity
I635_RS18790	COG0840	transmembrane signaling receptor activity
I635_RS18815	COG1757	Na H antiporter
I635_RS18820	COG1472	Belongs to the glycosyl hydrolase 3 family
I635_RS18830	COG2723	6-phospho-beta-galactosidase activity
I635_RS18835	COG1609	Transcriptional regulator
I635_RS18840	COG2814	Major facilitator Superfamily
I635_RS18840	COG0477	Major facilitator Superfamily
I635_RS18845	COG4319	ketosteroid isomerase
I635_RS18865	COG2375	cellular response to nickel ion
I635_RS18870	COG3237	CsbD-like
I635_RS18900	COG0508	dehydrogenase complex catalyzes the overall conversion of
I635_RS18900	COG0596	Alpha beta hydrolase
I635_RS18920	COG3038	cytochrome b561
I635_RS18930	COG1252	NADH dehydrogenase
I635_RS18945	COG0583	DNA-binding transcription factor activity
I635_RS18950	COG2067	long-chain fatty acid transport protein
I635_RS18955	COG2130	NADP-dependent
I635_RS18960	COG4251	negative regulation of phosphorylation
I635_RS18960	COG5001	Diguanylate cyclase
I635_RS18960	COG2203	Gaf domain
I635_RS18960	COG3706	GGDEF domain
I635_RS18965	COG2205	protein histidine kinase activity
I635_RS18965	COG0784	Response regulator, receiver
I635_RS18975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I635_RS18980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I635_RS18985	COG1349	DNA-binding transcription factor activity
I635_RS18990	COG0673	inositol 2-dehydrogenase activity
I635_RS19005	COG0697	spore germination
I635_RS19010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I635_RS19015	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I635_RS19020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I635_RS19025	COG1166	arginine decarboxylase activity
I635_RS19035	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I635_RS19115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I635_RS19120	COG0109	protoheme IX farnesyltransferase activity
I635_RS19140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I635_RS19155	COG1487	ribonuclease activity
I635_RS19185	COG3030	protein affecting phage T7 exclusion by the F plasmid
I635_RS19190	COG1324	tolerance protein
I635_RS19195	COG4232	protein-disulfide reductase activity
I635_RS19200	COG0739	heme binding
I635_RS19205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I635_RS19210	COG0511	ligase activity, forming carbon-carbon bonds
I635_RS19215	COG0439	Biotin carboxylase
I635_RS19265	COG0154	amidase activity
I635_RS19280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I635_RS19285	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I635_RS19300	COG0151	Belongs to the GarS family
I635_RS19315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I635_RS19320	COG3954	Phosphoribulokinase
I635_RS19345	COG1501	Belongs to the glycosyl hydrolase 31 family
I635_RS19355	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I635_RS19360	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I635_RS19370	COG3031	protein transport across the cell outer membrane
I635_RS19380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I635_RS19385	COG1459	type II secretion system
I635_RS19390	COG2165	general secretion pathway protein
I635_RS19395	COG2165	general secretion pathway protein
I635_RS19405	COG4795	General secretion pathway protein
I635_RS19420	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I635_RS19435	COG1012	belongs to the aldehyde dehydrogenase family
I635_RS19445	COG1011	Hydrolase
I635_RS19450	COG0494	nUDIX hydrolase
I635_RS19455	COG1218	3'(2'),5'-bisphosphate nucleotidase
I635_RS19465	COG2943	transferase activity, transferring hexosyl groups
I635_RS19470	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I635_RS19480	COG3089	Belongs to the UPF0270 family
I635_RS19485	COG0429	hydrolase of the alpha beta-hydrolase fold
I635_RS19495	COG0488	(ABC) transporter
I635_RS19510	COG2900	Belongs to the SlyX family
I635_RS19520	COG0545	Peptidyl-prolyl cis-trans isomerase
I635_RS19530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I635_RS19535	COG2183	response to ionizing radiation
I635_RS19565	COG2211	Major facilitator Superfamily
I635_RS19580	COG3693	PFAM glycoside hydrolase, family 10
I635_RS19585	COG0667	Aldo Keto reductase
I635_RS19590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I635_RS19595	COG2115	Belongs to the xylose isomerase family
I635_RS19600	COG1070	Carbohydrate kinase
I635_RS19615	COG1472	Belongs to the glycosyl hydrolase 3 family
I635_RS19620	COG0477	Major facilitator Superfamily
I635_RS19665	COG0596	Alpha beta hydrolase
I635_RS19670	COG1040	competence protein
I635_RS19690	COG1794	racemase activity, acting on amino acids and derivatives
I635_RS19700	COG0534	Mate efflux family protein
I635_RS19715	COG1999	signal sequence binding
I635_RS19720	COG0109	protoheme IX farnesyltransferase activity
I635_RS19725	COG1612	heme a metabolic process
I635_RS19745	COG1845	cytochrome c oxidase, subunit III
I635_RS19750	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I635_RS19755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I635_RS19760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I635_RS19780	COG0129	dihydroxy-acid dehydratase activity
I635_RS19790	COG0606	chelatase, subunit chli
I635_RS19795	COG0583	DNA-binding transcription factor activity
I635_RS19805	COG2814	Major facilitator Superfamily
I635_RS19815	COG0729	surface antigen
I635_RS19820	COG2911	Protein conserved in bacteria
I635_RS19845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I635_RS19855	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I635_RS19875	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I635_RS19900	COG1228	amidohydrolase
I635_RS19925	COG0425	Belongs to the sulfur carrier protein TusA family
I635_RS19940	COG1561	YicC-like family, N-terminal region
I635_RS19950	COG3550	peptidyl-serine autophosphorylation
I635_RS19955	COG3620	sequence-specific DNA binding
I635_RS20025	COG5433	transposase activity
I635_RS20030	COG3119	arylsulfatase activity
I635_RS20035	COG0714	Associated with various cellular activities
I635_RS20050	COG2304	oxidoreductase activity
I635_RS20080	COG0318	PFAM AMP-dependent synthetase and ligase
I635_RS20085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I635_RS20095	COG1960	acyl-CoA dehydrogenase activity
I635_RS20105	COG1024	Enoyl-CoA hydratase
I635_RS20115	COG2801	Transposase and inactivated derivatives
I635_RS20125	COG0800	Aldolase
I635_RS20135	COG0129	dihydroxy-acid dehydratase activity
I635_RS20145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I635_RS20150	COG1737	Transcriptional regulator
I635_RS20155	COG0469	pyruvate kinase activity
I635_RS20185	COG3177	Filamentation induced by cAMP protein fic
I635_RS20195	COG1609	Transcriptional regulator
I635_RS20210	COG2199	diguanylate cyclase activity
I635_RS20210	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I635_RS20235	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I635_RS20255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I635_RS20260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I635_RS20280	COG1475	DNA binding
I635_RS20285	COG1192	Involved in chromosome partitioning
I635_RS20315	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I635_RS20330	COG0706	membrane insertase activity
I635_RS20335	COG0594	ribonuclease P activity
I635_RS20340	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I635_RS20390	COG0187	DNA topoisomerase II activity
I635_RS20500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I635_RS20575	COG0009	L-threonylcarbamoyladenylate synthase
I635_RS20580	COG0408	coproporphyrinogen oxidase activity
I635_RS21285	COG0514	ATP-dependent DNA helicase (RecQ)
I635_RS21515	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I635_RS21785	COG1216	Glycosyl transferase, family 2
I635_RS21830	COG2202	Pas domain
I635_RS21830	COG3920	Histidine kinase
I635_RS21845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I635_RS21860	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I635_RS21865	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I635_RS21915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity