locus-tag	class	description
IUA53_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IUA53_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IUA53_RS00020	COG0187	DNA topoisomerase II activity
IUA53_RS00040	COG2818	Glycosylase
IUA53_RS00050	COG3078	GTPase activator activity
IUA53_RS00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IUA53_RS00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IUA53_RS00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IUA53_RS00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IUA53_RS00085	COG0569	domain protein
IUA53_RS00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IUA53_RS00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IUA53_RS00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IUA53_RS00105	COG1652	LysM domain
IUA53_RS00110	COG0758	DNA mediated transformation
IUA53_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
IUA53_RS00130	COG0408	coproporphyrinogen oxidase activity
IUA53_RS00135	COG3047	cAMP biosynthetic process
IUA53_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IUA53_RS00220	COG2234	aminopeptidase activity
IUA53_RS00225	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IUA53_RS00240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IUA53_RS00265	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUA53_RS00295	COG3642	lipopolysaccharide core region biosynthetic process
IUA53_RS00300	COG0859	PFAM glycosyl transferase family 9
IUA53_RS00320	COG0156	8-amino-7-oxononanoate synthase activity
IUA53_RS00330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IUA53_RS00335	COG0705	Rhomboid family
IUA53_RS00345	COG3161	chorismate lyase activity
IUA53_RS00350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IUA53_RS00355	COG2960	long-chain fatty acid transporting porin activity
IUA53_RS00360	COG0210	DNA helicase
IUA53_RS00405	COG0270	DNA (cytosine-5-)-methyltransferase activity
IUA53_RS00410	COG0556	nucleotide-excision repair
IUA53_RS00420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUA53_RS00425	COG0842	Transport permease protein
IUA53_RS00425	COG1129	ABC transporter
IUA53_RS00430	COG0842	Transport permease protein
IUA53_RS00435	COG4773	Receptor
IUA53_RS00440	COG4771	TonB-dependent receptor
IUA53_RS00445	COG3385	transposase activity
IUA53_RS00455	COG0583	DNA-binding transcription factor activity
IUA53_RS00465	COG3106	COG3106 Predicted ATPase
IUA53_RS00480	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IUA53_RS00500	COG0352	thiamine-phosphate diphosphorylase activity
IUA53_RS00510	COG4771	TonB-dependent receptor
IUA53_RS00525	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
IUA53_RS00525	COG0778	Nitroreductase
IUA53_RS00535	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IUA53_RS00540	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IUA53_RS00545	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IUA53_RS00550	COG1309	transcriptional regulator
IUA53_RS00575	COG1953	Uracil, thiamine, allantoin
IUA53_RS00585	COG3071	HemY protein
IUA53_RS00590	COG2959	enzyme of heme biosynthesis
IUA53_RS00595	COG1587	Uroporphyrinogen-III synthase
IUA53_RS00600	COG0181	hydroxymethylbilane synthase activity
IUA53_RS00615	COG0194	GDP metabolic process
IUA53_RS00625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IUA53_RS00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IUA53_RS00640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IUA53_RS00650	COG0678	peroxiredoxin activity
IUA53_RS00665	COG1178	ABC-type Fe3 transport system permease component
IUA53_RS00670	COG3842	ATPase activity
IUA53_RS00675	COG0668	transmembrane transport
IUA53_RS00680	COG2081	HI0933 family
IUA53_RS00760	COG4774	siderophore transport
IUA53_RS00770	COG0501	Belongs to the peptidase M48B family
IUA53_RS00775	COG0745	RESPONSE REGULATOR receiver
IUA53_RS00780	COG0457	Tetratricopeptide repeat
IUA53_RS00805	COG0010	Belongs to the arginase family
IUA53_RS00810	COG0010	Belongs to the arginase family
IUA53_RS00815	COG5002	protein histidine kinase activity
IUA53_RS00815	COG0784	Response regulator, receiver
IUA53_RS00815	COG2198	Histidine kinase
IUA53_RS00830	COG1172	Belongs to the binding-protein-dependent transport system permease family
IUA53_RS00845	COG0829	nickel cation binding
IUA53_RS00850	COG0831	urea catabolic process
IUA53_RS00870	COG0830	nickel cation binding
IUA53_RS00890	COG3706	GGDEF domain
IUA53_RS00920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUA53_RS00935	COG0427	acetyl-CoA hydrolase
IUA53_RS00940	COG0123	including yeast histone deacetylase and acetoin utilization protein
IUA53_RS00965	COG3064	Membrane
IUA53_RS00975	COG5001	Diguanylate cyclase
IUA53_RS00975	COG5002	protein histidine kinase activity
IUA53_RS00990	COG0514	ATP-dependent DNA helicase (RecQ)
IUA53_RS01000	COG2239	Acts as a magnesium transporter
IUA53_RS01005	COG2962	Rard protein
IUA53_RS01015	COG0210	DNA helicase
IUA53_RS01025	COG1011	Hydrolase
IUA53_RS01040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IUA53_RS01045	COG0019	diaminopimelate decarboxylase activity
IUA53_RS01075	COG0163	prenyltransferase activity
IUA53_RS01080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IUA53_RS01090	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IUA53_RS01115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IUA53_RS01120	COG2814	Major facilitator Superfamily
IUA53_RS01125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUA53_RS01155	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IUA53_RS01165	COG0629	single-stranded DNA binding
IUA53_RS01195	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IUA53_RS01210	COG1349	DNA-binding transcription factor activity
IUA53_RS01230	COG1077	Cell shape determining protein MreB Mrl
IUA53_RS01235	COG1792	Involved in formation and maintenance of cell shape
IUA53_RS01240	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IUA53_RS01245	COG0424	maF-like protein
IUA53_RS01250	COG1530	ribonuclease E activity
IUA53_RS01255	COG3164	Protein of unknown function
IUA53_RS01260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IUA53_RS01265	COG0312	modulator of DNA gyrase
IUA53_RS01270	COG3028	Belongs to the UPF0307 family
IUA53_RS01275	COG0312	modulator of DNA gyrase
IUA53_RS01290	COG0745	RESPONSE REGULATOR receiver
IUA53_RS01295	COG4191	Histidine kinase
IUA53_RS01295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUA53_RS01300	COG0297	glycogen (starch) synthase activity
IUA53_RS01310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IUA53_RS01360	COG0732	type I restriction modification DNA specificity domain
IUA53_RS01395	COG0328	RNA-DNA hybrid ribonuclease activity
IUA53_RS01395	COG3341	Caulimovirus viroplasmin
IUA53_RS01415	COG4974	Belongs to the 'phage' integrase family
IUA53_RS01520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IUA53_RS01555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IUA53_RS01565	COG0463	Glycosyl transferase, family 2
IUA53_RS01570	COG0745	RESPONSE REGULATOR receiver
IUA53_RS01575	COG5002	protein histidine kinase activity
IUA53_RS01615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IUA53_RS01635	COG0789	Transcriptional regulator
IUA53_RS01640	COG2217	Heavy metal translocating P-type atpase
IUA53_RS01680	COG0531	amino acid
IUA53_RS01690	COG2132	Multicopper oxidase
IUA53_RS01770	COG2378	regulation of single-species biofilm formation
IUA53_RS01780	COG4771	TonB-dependent receptor
IUA53_RS01800	COG0840	transmembrane signaling receptor activity
IUA53_RS01805	COG0745	RESPONSE REGULATOR receiver
IUA53_RS01810	COG0643	Histidine kinase
IUA53_RS01810	COG2198	Histidine kinase
IUA53_RS01815	COG0835	chemotaxis
IUA53_RS01830	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IUA53_RS01860	COG3437	response regulator, receiver
IUA53_RS01865	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IUA53_RS01880	COG1609	Transcriptional regulator
IUA53_RS01885	COG0673	inositol 2-dehydrogenase activity
IUA53_RS01895	COG2211	Major facilitator Superfamily
IUA53_RS01920	COG0346	lactoylglutathione lyase activity
IUA53_RS01925	COG4989	oxidoreductase activity
IUA53_RS01930	COG3040	lipid binding
IUA53_RS01940	COG0418	dihydroorotase activity
IUA53_RS01945	COG0513	Belongs to the DEAD box helicase family
IUA53_RS01955	COG3590	peptidase
IUA53_RS01960	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IUA53_RS01970	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IUA53_RS01975	COG1132	(ABC) transporter
IUA53_RS01985	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IUA53_RS01990	COG0250	Participates in transcription elongation, termination and antitermination
IUA53_RS02000	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IUA53_RS02005	COG0081	regulation of translation
IUA53_RS02010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IUA53_RS02015	COG0222	ribosome binding
IUA53_RS02020	COG0085	RNA polymerase activity
IUA53_RS02025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IUA53_RS02030	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IUA53_RS02035	COG0049	tRNA binding
IUA53_RS02040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IUA53_RS02050	COG0657	acetylesterase activity
IUA53_RS02060	COG1966	Carbon starvation protein
IUA53_RS02065	COG0701	Predicted permease
IUA53_RS02070	COG1253	flavin adenine dinucleotide binding
IUA53_RS02090	COG4774	siderophore transport
IUA53_RS02095	COG2205	protein histidine kinase activity
IUA53_RS02100	COG0745	RESPONSE REGULATOR receiver
IUA53_RS02105	COG1131	(ABC) transporter
IUA53_RS02110	COG0842	Transport permease protein
IUA53_RS02120	COG0076	glutamate decarboxylase activity
IUA53_RS02135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IUA53_RS02150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IUA53_RS02170	COG2095	MarC family integral membrane protein
IUA53_RS02180	COG0742	ribosomal rna small subunit methyltransferase
IUA53_RS02185	COG0552	protein localization to endoplasmic reticulum
IUA53_RS02190	COG2884	Cell division ATP-binding protein ftsE
IUA53_RS02195	COG2177	Part of the ABC transporter FtsEX involved in
IUA53_RS02200	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IUA53_RS02205	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IUA53_RS02215	COG0456	acetyltransferase
IUA53_RS02245	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IUA53_RS02255	COG0281	malic enzyme
IUA53_RS02270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IUA53_RS02275	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IUA53_RS02280	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IUA53_RS02320	COG0823	Involved in the tonB-independent uptake of proteins
IUA53_RS02320	COG1506	peptidase
IUA53_RS02320	COG4946	Tricorn protease homolog
IUA53_RS02325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUA53_RS02335	COG4191	Histidine kinase
IUA53_RS02335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUA53_RS02345	COG2201	protein-glutamate methylesterase activity
IUA53_RS02350	COG0339	signal peptide processing
IUA53_RS02370	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IUA53_RS02375	COG1278	Cold shock
IUA53_RS02385	COG0840	transmembrane signaling receptor activity
IUA53_RS02390	COG1294	oxidase, subunit
IUA53_RS02395	COG1271	oxidase subunit
IUA53_RS02430	COG2234	aminopeptidase activity
IUA53_RS02455	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IUA53_RS02475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IUA53_RS02485	COG2205	protein histidine kinase activity
IUA53_RS02485	COG0784	Response regulator, receiver
IUA53_RS02520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IUA53_RS02540	COG0201	protein transport
IUA53_RS02565	COG0202	RNA polymerase activity
IUA53_RS02575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IUA53_RS02585	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IUA53_RS02585	COG0662	Cupin 2, conserved barrel domain protein
IUA53_RS02670	COG1091	dTDP-4-dehydrorhamnose reductase activity
IUA53_RS02680	COG1216	Glycosyl transferase, family 2
IUA53_RS02680	COG0438	transferase activity, transferring glycosyl groups
IUA53_RS02695	COG1216	Glycosyl transferase, family 2
IUA53_RS02695	COG1442	glycosyl transferase family 8
IUA53_RS02710	COG0463	Glycosyl transferase, family 2
IUA53_RS02715	COG1216	Glycosyl transferase, family 2
IUA53_RS02745	COG0583	DNA-binding transcription factor activity
IUA53_RS02795	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IUA53_RS02805	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IUA53_RS02840	COG0753	catalase activity
IUA53_RS02855	COG0667	Aldo Keto reductase
IUA53_RS02860	COG1283	sodium-dependent phosphate transmembrane transporter activity
IUA53_RS02870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IUA53_RS02885	COG0189	ligase activity
IUA53_RS02885	COG4067	protein conserved in archaea
IUA53_RS02895	COG0189	ligase activity
IUA53_RS02905	COG0784	Response regulator, receiver
IUA53_RS02905	COG2198	Histidine kinase
IUA53_RS02905	COG5002	protein histidine kinase activity
IUA53_RS02915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IUA53_RS02920	COG0517	IMP dehydrogenase activity
IUA53_RS02920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IUA53_RS02945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IUA53_RS02950	COG0572	uridine kinase
IUA53_RS02980	COG4206	TonB-dependent receptor
IUA53_RS02985	COG1438	arginine binding
IUA53_RS02990	COG0039	L-malate dehydrogenase activity
IUA53_RS03005	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IUA53_RS03010	COG0545	Peptidyl-prolyl cis-trans isomerase
IUA53_RS03015	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IUA53_RS03020	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IUA53_RS03025	COG1805	sodium ion transport
IUA53_RS03030	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IUA53_RS03035	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IUA53_RS03040	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IUA53_RS03045	COG2871	sodium ion transport
IUA53_RS03050	COG1477	protein flavinylation
IUA53_RS03060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IUA53_RS03075	COG1609	Transcriptional regulator
IUA53_RS03080	COG3265	gluconokinase activity
IUA53_RS03085	COG2610	gluconate transmembrane transporter activity
IUA53_RS03090	COG4628	conserved protein (DUF2132)
IUA53_RS03105	COG0577	efflux transmembrane transporter activity
IUA53_RS03105	COG1136	(ABC) transporter
IUA53_RS03115	COG1522	sequence-specific DNA binding
IUA53_RS03140	COG0121	glutamine amidotransferase
IUA53_RS03155	COG0583	DNA-binding transcription factor activity
IUA53_RS03165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IUA53_RS03170	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IUA53_RS03180	COG5002	protein histidine kinase activity
IUA53_RS03180	COG5001	Diguanylate cyclase
IUA53_RS03200	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IUA53_RS03210	COG0848	biopolymer transport protein
IUA53_RS03220	COG0716	FMN binding
IUA53_RS03235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IUA53_RS03250	COG0733	neurotransmitter:sodium symporter activity
IUA53_RS03255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IUA53_RS03270	COG0668	transmembrane transport
IUA53_RS03275	COG0204	Acyl-transferase
IUA53_RS03280	COG0204	Acyl-transferase
IUA53_RS03295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IUA53_RS03310	COG4529	Protein conserved in bacteria
IUA53_RS03325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IUA53_RS03335	COG1842	Phage shock protein A
IUA53_RS03360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IUA53_RS03385	COG1573	uracil-dna glycosylase
IUA53_RS03395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUA53_RS03460	COG3385	transposase activity
IUA53_RS03470	COG0417	DNA replication proofreading
IUA53_RS03475	COG4191	Histidine kinase
IUA53_RS03490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IUA53_RS03495	COG0730	response to heat
IUA53_RS03510	COG3568	Endonuclease Exonuclease Phosphatase
IUA53_RS03525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IUA53_RS03525	COG0475	glutathione-regulated potassium exporter activity
IUA53_RS03545	COG2207	Transcriptional regulator
IUA53_RS03550	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IUA53_RS03550	COG3264	Mechanosensitive ion channel
IUA53_RS03565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUA53_RS03570	COG0800	Aldolase
IUA53_RS03580	COG0513	Belongs to the DEAD box helicase family
IUA53_RS03600	COG1116	anion transmembrane transporter activity
IUA53_RS03615	COG2267	carboxylic ester hydrolase activity
IUA53_RS03635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUA53_RS03655	COG1609	Transcriptional regulator
IUA53_RS03670	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_RS03680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IUA53_RS03690	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IUA53_RS03695	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IUA53_RS03700	COG4139	cobalamin transport
IUA53_RS03705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IUA53_RS03710	COG4206	TonB-dependent receptor
IUA53_RS03765	COG0793	Belongs to the peptidase S41A family
IUA53_RS03765	COG4946	Tricorn protease homolog
IUA53_RS03780	COG3661	Belongs to the glycosyl hydrolase 67 family
IUA53_RS03785	COG4948	Mandelate Racemase Muconate Lactonizing
IUA53_RS03805	COG3250	beta-galactosidase activity
IUA53_RS03845	COG1484	DNA-dependent DNA replication
IUA53_RS03850	COG4584	PFAM Integrase catalytic
IUA53_RS03930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IUA53_RS03985	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IUA53_RS04065	COG1250	3-hydroxyacyl-CoA dehydrogenase
IUA53_RS04070	COG3246	L-lysine catabolic process to acetate
IUA53_RS04080	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_RS04085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IUA53_RS04090	COG1414	Transcriptional regulator
IUA53_RS04100	COG0795	lipopolysaccharide-transporting ATPase activity
IUA53_RS04105	COG0795	lipopolysaccharide-transporting ATPase activity
IUA53_RS04110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IUA53_RS04115	COG2927	DNA polymerase III (CHI subunit)
IUA53_RS04120	COG0525	valine-tRNA ligase activity
IUA53_RS04155	COG3437	response regulator, receiver
IUA53_RS04160	COG2204	response regulator
IUA53_RS04165	COG3852	Histidine kinase
IUA53_RS04175	COG0174	glutamine synthetase
IUA53_RS04180	COG1217	gtp-binding protein TYPA
IUA53_RS04190	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IUA53_RS04195	COG1914	H( )-stimulated, divalent metal cation uptake system
IUA53_RS04210	COG1981	membrane
IUA53_RS04240	COG0850	regulation of cytokinetic process
IUA53_RS04245	COG2894	cell division
IUA53_RS04275	COG0625	glutathione transferase activity
IUA53_RS04295	COG0784	Response regulator, receiver
IUA53_RS04295	COG2205	protein histidine kinase activity
IUA53_RS04295	COG5002	protein histidine kinase activity
IUA53_RS04300	COG3437	response regulator, receiver
IUA53_RS04305	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IUA53_RS04310	COG1196	nuclear chromosome segregation
IUA53_RS04310	COG0739	heme binding
IUA53_RS04310	COG0741	lytic transglycosylase activity
IUA53_RS04315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IUA53_RS04320	COG5507	3-demethylubiquinone-9 3-methyltransferase
IUA53_RS04330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IUA53_RS04340	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IUA53_RS04355	COG0493	'glutamate synthase
IUA53_RS04360	COG0067	glutamate synthase
IUA53_RS04360	COG0070	glutamate synthase
IUA53_RS04360	COG0069	glutamate synthase activity
IUA53_RS04365	COG3023	N-Acetylmuramoyl-L-alanine amidase
IUA53_RS04370	COG0784	Response regulator, receiver
IUA53_RS04370	COG5002	protein histidine kinase activity
IUA53_RS04370	COG2198	Histidine kinase
IUA53_RS04390	COG2203	Gaf domain
IUA53_RS04390	COG2199	diguanylate cyclase activity
IUA53_RS04395	COG2828	Protein conserved in bacteria
IUA53_RS04400	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IUA53_RS04405	COG0372	Belongs to the citrate synthase family
IUA53_RS04410	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IUA53_RS04430	COG2823	Periplasmic or secreted lipoprotein
IUA53_RS04440	COG0792	nuclease activity
IUA53_RS04450	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IUA53_RS04470	COG1748	Saccharopine dehydrogenase
IUA53_RS04480	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IUA53_RS04495	COG2205	protein histidine kinase activity
IUA53_RS04505	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
IUA53_RS04510	COG2201	protein-glutamate methylesterase activity
IUA53_RS04515	COG0798	PFAM Bile acid sodium symporter
IUA53_RS04520	COG0431	NADPH-dependent FMN reductase
IUA53_RS04530	COG0640	Transcriptional regulator
IUA53_RS04545	COG0583	DNA-binding transcription factor activity
IUA53_RS04555	COG0083	homoserine kinase activity
IUA53_RS04560	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IUA53_RS04565	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IUA53_RS04595	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IUA53_RS04625	COG0446	pyridine nucleotide-disulphide oxidoreductase
IUA53_RS04625	COG1902	pentaerythritol trinitrate reductase activity
IUA53_RS04635	COG0762	integral membrane protein
IUA53_RS04640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IUA53_RS04645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IUA53_RS04665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IUA53_RS04670	COG1678	Uncharacterized ACR, COG1678
IUA53_RS04680	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IUA53_RS04685	COG0668	transmembrane transport
IUA53_RS04690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IUA53_RS04730	COG2271	Major facilitator Superfamily
IUA53_RS04735	COG2084	Dehydrogenase
IUA53_RS04750	COG2204	response regulator
IUA53_RS04765	COG0678	peroxiredoxin activity
IUA53_RS04765	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IUA53_RS04790	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUA53_RS04805	COG2001	Belongs to the MraZ family
IUA53_RS04815	COG3116	cell division
IUA53_RS04820	COG0768	penicillin binding
IUA53_RS04825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IUA53_RS04830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IUA53_RS04840	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IUA53_RS04845	COG0772	Belongs to the SEDS family
IUA53_RS04855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IUA53_RS04860	COG1181	Belongs to the D-alanine--D-alanine ligase family
IUA53_RS04865	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IUA53_RS04870	COG0849	cell division
IUA53_RS04875	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IUA53_RS04880	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IUA53_RS04885	COG0739	heme binding
IUA53_RS04900	COG3608	succinylglutamate desuccinylase aspartoacylase
IUA53_RS04905	COG1629	transport
IUA53_RS04910	COG0702	epimerase
IUA53_RS04915	COG2814	Major facilitator Superfamily
IUA53_RS04920	COG1621	beta-fructofuranosidase activity
IUA53_RS04940	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IUA53_RS04945	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
IUA53_RS04950	COG0237	dephospho-CoA kinase activity
IUA53_RS04960	COG1459	type II secretion system
IUA53_RS04965	COG4969	Belongs to the N-Me-Phe pilin family
IUA53_RS04975	COG3577	Aspartyl protease
IUA53_RS04995	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IUA53_RS05000	COG0508	dehydrogenase complex catalyzes the overall conversion of
IUA53_RS05005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUA53_RS05025	COG3313	Fe-S protein
IUA53_RS05045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IUA53_RS05050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IUA53_RS05055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IUA53_RS05065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUA53_RS05080	COG0006	proline dipeptidase activity
IUA53_RS05085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IUA53_RS05090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IUA53_RS05100	COG0006	proline dipeptidase activity
IUA53_RS05105	COG0583	DNA-binding transcription factor activity
IUA53_RS05120	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IUA53_RS05120	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IUA53_RS05130	COG1203	CRISPR-associated helicase, Cas3
IUA53_RS05165	COG1518	maintenance of DNA repeat elements
IUA53_RS05170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IUA53_RS05195	COG1312	Catalyzes the dehydration of D-mannonate
IUA53_RS05225	COG0235	Class ii aldolase
IUA53_RS05240	COG0513	Belongs to the DEAD box helicase family
IUA53_RS05255	COG4555	ABC transporter
IUA53_RS05265	COG3850	Histidine kinase
IUA53_RS05265	COG2205	protein histidine kinase activity
IUA53_RS05265	COG3437	response regulator, receiver
IUA53_RS05265	COG4999	Histidine kinase
IUA53_RS05270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IUA53_RS05275	COG1764	response to oxidative stress
IUA53_RS05280	COG0596	Alpha beta hydrolase
IUA53_RS05290	COG5002	protein histidine kinase activity
IUA53_RS05290	COG0784	Response regulator, receiver
IUA53_RS05290	COG2205	protein histidine kinase activity
IUA53_RS05310	COG2267	carboxylic ester hydrolase activity
IUA53_RS05315	COG0514	ATP-dependent DNA helicase (RecQ)
IUA53_RS05355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IUA53_RS05370	COG2115	Belongs to the xylose isomerase family
IUA53_RS05375	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IUA53_RS05380	COG1070	Carbohydrate kinase
IUA53_RS05410	COG1609	Transcriptional regulator
IUA53_RS05410	COG2207	Transcriptional regulator
IUA53_RS05420	COG0477	Major facilitator Superfamily
IUA53_RS05500	COG2197	response regulator
IUA53_RS05505	COG1295	ribonuclease BN
IUA53_RS05545	COG1595	DNA-templated transcription, initiation
IUA53_RS05555	COG0402	S-adenosylhomocysteine deaminase activity
IUA53_RS05560	COG2233	PERMEase
IUA53_RS05580	COG0693	protein deglycase activity
IUA53_RS05625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IUA53_RS05645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IUA53_RS05650	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IUA53_RS05655	COG2080	2 iron, 2 sulfur cluster binding
IUA53_RS05680	COG1960	acyl-CoA dehydrogenase activity
IUA53_RS05695	COG1484	DNA-dependent DNA replication
IUA53_RS05700	COG4584	PFAM Integrase catalytic
IUA53_RS05710	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
IUA53_RS05725	COG1250	3-hydroxyacyl-CoA dehydrogenase
IUA53_RS05725	COG1024	Enoyl-CoA hydratase
IUA53_RS05735	COG0515	serine threonine protein kinase
IUA53_RS05735	COG2815	serine threonine protein kinase
IUA53_RS05750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IUA53_RS05755	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IUA53_RS05790	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IUA53_RS05795	COG1609	Transcriptional regulator
IUA53_RS05800	COG1435	thymidine kinase activity
IUA53_RS05820	COG1960	acyl-CoA dehydrogenase activity
IUA53_RS05830	COG1560	Kdo2-lipid A biosynthetic process
IUA53_RS05850	COG2827	Endonuclease containing a URI domain
IUA53_RS05860	COG3267	Type II secretory pathway component ExeA
IUA53_RS05860	COG3409	Peptidoglycan-binding domain 1 protein
IUA53_RS05870	COG0489	protein tyrosine kinase activity
IUA53_RS05935	COG2755	lipolytic protein G-D-S-L family
IUA53_RS05935	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IUA53_RS05965	COG0367	asparagine synthase
IUA53_RS06000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IUA53_RS06065	COG0745	RESPONSE REGULATOR receiver
IUA53_RS06070	COG1785	Belongs to the alkaline phosphatase family
IUA53_RS06075	COG2066	Belongs to the glutaminase family
IUA53_RS06090	COG0754	glutathionylspermidine amidase activity
IUA53_RS06115	COG1842	Phage shock protein A
IUA53_RS06135	COG0343	queuine tRNA-ribosyltransferase activity
IUA53_RS06140	COG1862	Preprotein translocase
IUA53_RS06145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IUA53_RS06150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IUA53_RS06165	COG0483	inositol monophosphate 1-phosphatase activity
IUA53_RS06170	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IUA53_RS06175	COG1045	serine acetyltransferase
IUA53_RS06185	COG1104	cysteine desulfurase activity
IUA53_RS06190	COG0719	Fe-S assembly protein
IUA53_RS06195	COG0396	ATPase activity
IUA53_RS06200	COG0719	Fe-S assembly protein
IUA53_RS06205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IUA53_RS06220	COG2166	iron-sulfur cluster assembly
IUA53_RS06230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IUA53_RS06240	COG1426	Protein conserved in bacteria
IUA53_RS06255	COG2976	Protein conserved in bacteria
IUA53_RS06260	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUA53_RS06275	COG1570	exodeoxyribonuclease VII activity
IUA53_RS06280	COG0516	GMP reductase activity
IUA53_RS06280	COG0517	IMP dehydrogenase activity
IUA53_RS06295	COG0123	including yeast histone deacetylase and acetoin utilization protein
IUA53_RS06315	COG1720	tRNA m6t6A37 methyltransferase activity
IUA53_RS06355	COG0544	peptidyl-prolyl cis-trans isomerase activity
IUA53_RS06360	COG0740	serine-type endopeptidase activity
IUA53_RS06365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IUA53_RS06370	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IUA53_RS06375	COG0776	regulation of translation
IUA53_RS06380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IUA53_RS06405	COG0268	Binds directly to 16S ribosomal RNA
IUA53_RS06410	COG0728	peptidoglycan biosynthetic process
IUA53_RS06415	COG0196	riboflavin kinase activity
IUA53_RS06420	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IUA53_RS06430	COG1047	Peptidyl-prolyl cis-trans
IUA53_RS06435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IUA53_RS06475	COG4795	General secretion pathway protein
IUA53_RS06515	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IUA53_RS06530	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IUA53_RS06535	COG1595	DNA-templated transcription, initiation
IUA53_RS06580	COG0084	hydrolase, TatD family'
IUA53_RS06590	COG0560	Phosphoserine phosphatase
IUA53_RS06600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IUA53_RS06610	COG0488	(ABC) transporter
IUA53_RS06615	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IUA53_RS06630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IUA53_RS06630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IUA53_RS06645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IUA53_RS06660	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IUA53_RS06670	COG0142	geranyltranstransferase activity
IUA53_RS06680	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IUA53_RS06690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IUA53_RS06705	COG4221	oxidoreductase activity
IUA53_RS06720	COG1595	DNA-templated transcription, initiation
IUA53_RS06735	COG0564	pseudouridine synthase activity
IUA53_RS06745	COG0542	response to heat
IUA53_RS06765	COG1183	phosphatidylcholine synthase activity
IUA53_RS06795	COG4251	negative regulation of phosphorylation
IUA53_RS06795	COG2203	Gaf domain
IUA53_RS06795	COG5001	Diguanylate cyclase
IUA53_RS06795	COG3706	GGDEF domain
IUA53_RS06805	COG2319	Wd-40 repeat
IUA53_RS06805	COG4249	Peptidase C14 caspase catalytic subunit p20
IUA53_RS06815	COG3220	belongs to the UPF0276 family
IUA53_RS06825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IUA53_RS06830	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IUA53_RS06850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IUA53_RS06855	COG0326	Molecular chaperone. Has ATPase activity
IUA53_RS06880	COG2116	formate transmembrane transporter activity
IUA53_RS06885	COG0583	DNA-binding transcription factor activity
IUA53_RS06890	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IUA53_RS06890	COG0140	phosphoribosyl-ATP diphosphatase activity
IUA53_RS06905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IUA53_RS06910	COG0131	Imidazoleglycerol-phosphate dehydratase
IUA53_RS06910	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IUA53_RS06915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IUA53_RS06920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IUA53_RS06935	COG4771	TonB-dependent receptor
IUA53_RS06940	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IUA53_RS06965	COG1199	ATP-dependent helicase activity
IUA53_RS06970	COG1214	PFAM Peptidase M22, glycoprotease
IUA53_RS06985	COG2267	carboxylic ester hydrolase activity
IUA53_RS06990	COG0318	PFAM AMP-dependent synthetase and ligase
IUA53_RS06995	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IUA53_RS07010	COG0179	Fumarylacetoacetate (FAA) hydrolase
IUA53_RS07015	COG2983	Belongs to the UPF0260 family
IUA53_RS07020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IUA53_RS07025	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IUA53_RS07035	COG2186	Transcriptional regulator
IUA53_RS07065	COG4399	Belongs to the UPF0754 family
IUA53_RS07075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IUA53_RS07100	COG1902	pentaerythritol trinitrate reductase activity
IUA53_RS07100	COG0446	pyridine nucleotide-disulphide oxidoreductase
IUA53_RS07120	COG3101	peptidyl-lysine hydroxylation
IUA53_RS07140	COG0668	transmembrane transport
IUA53_RS07165	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IUA53_RS07165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IUA53_RS07170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IUA53_RS07180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IUA53_RS07205	COG0285	dihydrofolate synthase activity
IUA53_RS07210	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IUA53_RS07215	COG1286	toxin biosynthetic process
IUA53_RS07220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IUA53_RS07235	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
IUA53_RS07240	COG0583	DNA-binding transcription factor activity
IUA53_RS07250	COG2268	Band 7 protein
IUA53_RS07265	COG1785	Belongs to the alkaline phosphatase family
IUA53_RS07270	COG1785	Belongs to the alkaline phosphatase family
IUA53_RS07280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IUA53_RS07285	COG0215	cysteine-tRNA ligase activity
IUA53_RS07295	COG0741	lytic transglycosylase activity
IUA53_RS07295	COG1388	LysM domain
IUA53_RS07300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IUA53_RS07305	COG2226	methyltransferase
IUA53_RS07310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IUA53_RS07310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IUA53_RS07315	COG0489	protein tyrosine kinase activity
IUA53_RS07325	COG0471	metal ion transport
IUA53_RS07350	COG0330	HflC and HflK could
IUA53_RS07390	COG4191	Histidine kinase
IUA53_RS07390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUA53_RS07395	COG3437	response regulator, receiver
IUA53_RS07395	COG0784	Response regulator, receiver
IUA53_RS07405	COG2205	protein histidine kinase activity
IUA53_RS07410	COG0745	RESPONSE REGULATOR receiver
IUA53_RS07450	COG4948	Mandelate Racemase Muconate Lactonizing
IUA53_RS07455	COG1609	Transcriptional regulator
IUA53_RS07470	COG1119	ATPase activity
IUA53_RS07480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUA53_RS07485	COG0308	aminopeptidase N
IUA53_RS07500	COG4677	pectinesterase activity
IUA53_RS07510	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IUA53_RS07520	COG2755	lipolytic protein G-D-S-L family
IUA53_RS07525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUA53_RS07530	COG0246	Mannitol dehydrogenase
IUA53_RS07535	COG1904	glucuronate isomerase
IUA53_RS07540	COG2721	sulfolactate sulfo-lyase activity
IUA53_RS07565	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IUA53_RS07570	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_RS07605	COG0745	RESPONSE REGULATOR receiver
IUA53_RS07610	COG2205	protein histidine kinase activity
IUA53_RS07650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IUA53_RS07655	COG0469	pyruvate kinase activity
IUA53_RS07660	COG1737	Transcriptional regulator
IUA53_RS07665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IUA53_RS07675	COG0129	dihydroxy-acid dehydratase activity
IUA53_RS07680	COG0837	glucose binding
IUA53_RS07685	COG0800	Aldolase
IUA53_RS07690	COG0676	glucose-6-phosphate 1-epimerase activity
IUA53_RS07700	COG1640	4-alpha-glucanotransferase
IUA53_RS07705	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IUA53_RS07715	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IUA53_RS07735	COG2866	Carboxypeptidase
IUA53_RS07740	COG1115	amino acid carrier protein
IUA53_RS07750	COG3139	Protein of unknown function (DUF1315)
IUA53_RS07795	COG2205	protein histidine kinase activity
IUA53_RS07795	COG0784	Response regulator, receiver
IUA53_RS07800	COG0784	Response regulator, receiver
IUA53_RS07805	COG4251	negative regulation of phosphorylation
IUA53_RS07815	COG2204	response regulator
IUA53_RS07835	COG0640	Transcriptional regulator
IUA53_RS07845	COG3085	chromosome segregation
IUA53_RS07855	COG0583	DNA-binding transcription factor activity
IUA53_RS07870	COG3132	Protein of unknown function, DUF480
IUA53_RS07885	COG1022	Amp-dependent synthetase and ligase
IUA53_RS07895	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IUA53_RS07900	COG1074	ATP-dependent DNA helicase activity
IUA53_RS07905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IUA53_RS07930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IUA53_RS07935	COG3268	Saccharopine dehydrogenase
IUA53_RS07940	COG0436	Aminotransferase
IUA53_RS07960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IUA53_RS07965	COG0521	Mo-molybdopterin cofactor biosynthetic process
IUA53_RS07970	COG0315	cyclic pyranopterin monophosphate synthase activity
IUA53_RS07975	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IUA53_RS07995	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IUA53_RS07995	COG1618	nucleotide phosphatase activity, acting on free nucleotides
IUA53_RS08015	COG4771	TonB-dependent receptor
IUA53_RS08050	COG0596	Alpha beta hydrolase
IUA53_RS08055	COG1024	Enoyl-CoA hydratase
IUA53_RS08055	COG1250	3-hydroxyacyl-CoA dehydrogenase
IUA53_RS08060	COG0183	Belongs to the thiolase family
IUA53_RS08065	COG1960	acyl-CoA dehydrogenase activity
IUA53_RS08075	COG2390	Transcriptional regulator
IUA53_RS08080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUA53_RS08115	COG0668	transmembrane transport
IUA53_RS08120	COG4771	TonB-dependent receptor
IUA53_RS08145	COG3437	response regulator, receiver
IUA53_RS08155	COG0195	Participates in both transcription termination and antitermination
IUA53_RS08170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IUA53_RS08180	COG3706	GGDEF domain
IUA53_RS08185	COG0596	Alpha beta hydrolase
IUA53_RS08195	COG3153	acetyltransferase
IUA53_RS08195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IUA53_RS08245	COG0662	Cupin 2, conserved barrel domain protein
IUA53_RS08275	COG4771	TonB-dependent receptor
IUA53_RS08280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUA53_RS08290	COG4134	Bacterial extracellular solute-binding protein
IUA53_RS08295	COG4135	transport system, permease component
IUA53_RS08300	COG4136	ATPase activity
IUA53_RS08305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IUA53_RS08315	COG3932	Exopolysaccharide synthesis, ExoD
IUA53_RS08320	COG0604	alcohol dehydrogenase
IUA53_RS08355	COG0840	transmembrane signaling receptor activity
IUA53_RS08375	COG1131	(ABC) transporter
IUA53_RS08390	COG1902	pentaerythritol trinitrate reductase activity
IUA53_RS08400	COG2867	negative regulation of translational initiation
IUA53_RS08405	COG2914	Belongs to the UPF0125 (RnfH) family
IUA53_RS08415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IUA53_RS08420	COG4771	TonB-dependent receptor
IUA53_RS08425	COG0457	Tetratricopeptide repeat
IUA53_RS08435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IUA53_RS08435	COG0574	Belongs to the PEP-utilizing enzyme family
IUA53_RS08455	COG0247	lactate metabolic process
IUA53_RS08455	COG0277	FAD linked oxidase domain protein
IUA53_RS08465	COG2850	peptidyl-arginine hydroxylation
IUA53_RS08475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IUA53_RS08480	COG2915	High frequency lysogenization protein hflD homolog
IUA53_RS08485	COG0482	sulfurtransferase activity
IUA53_RS08490	COG1187	pseudouridine synthase activity
IUA53_RS08500	COG1278	Cold shock
IUA53_RS08505	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IUA53_RS08510	COG0542	response to heat
IUA53_RS08515	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IUA53_RS08520	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IUA53_RS08525	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IUA53_RS08530	COG0492	ferredoxin-NADP+ reductase activity
IUA53_RS08535	COG3092	negative regulation of chromosome organization
IUA53_RS08540	COG3091	SprT-like family
IUA53_RS08545	COG0616	signal peptide processing
IUA53_RS08550	COG0778	Nitroreductase
IUA53_RS08560	COG0252	asparaginase activity
IUA53_RS08565	COG3706	GGDEF domain
IUA53_RS08570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IUA53_RS08575	COG0321	lipoyl(octanoyl) transferase activity
IUA53_RS08580	COG2921	Belongs to the UPF0250 family
IUA53_RS08585	COG1686	Belongs to the peptidase S11 family
IUA53_RS08590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IUA53_RS08595	COG0772	Belongs to the SEDS family
IUA53_RS08600	COG0768	penicillin binding
IUA53_RS08605	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IUA53_RS08610	COG0799	negative regulation of ribosome biogenesis
IUA53_RS08615	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IUA53_RS08620	COG1466	dna polymerase III delta subunit
IUA53_RS08625	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
IUA53_RS08630	COG0495	leucyl-tRNA aminoacylation
IUA53_RS08635	COG1067	ATP-dependent peptidase activity
IUA53_RS08645	COG1534	Rna-binding protein
IUA53_RS08650	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IUA53_RS08660	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IUA53_RS08665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IUA53_RS08670	COG0149	triose-phosphate isomerase activity
IUA53_RS08675	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IUA53_RS08685	COG1716	ATPase activity
IUA53_RS08685	COG5001	Diguanylate cyclase
IUA53_RS08715	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_RS08730	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IUA53_RS08735	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IUA53_RS08740	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IUA53_RS08755	COG1185	polyribonucleotide nucleotidyltransferase activity
IUA53_RS08775	COG0295	cytidine deaminase activity
IUA53_RS08790	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
IUA53_RS08795	COG1196	nuclear chromosome segregation
IUA53_RS08805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IUA53_RS08815	COG0658	competence protein
IUA53_RS08815	COG2333	competence protein COMEC
IUA53_RS08820	COG1132	(ABC) transporter
IUA53_RS08825	COG1663	tetraacyldisaccharide 4'-kinase activity
IUA53_RS08895	COG2808	Putative FMN-binding domain
IUA53_RS08990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IUA53_RS08995	COG0435	Glutathione S-transferase
IUA53_RS09020	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IUA53_RS09025	COG1053	succinate dehydrogenase
IUA53_RS09030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IUA53_RS09035	COG0567	Dehydrogenase, E1 component
IUA53_RS09040	COG0508	dehydrogenase complex catalyzes the overall conversion of
IUA53_RS09075	COG4667	esterase of the alpha-beta hydrolase superfamily
IUA53_RS09090	COG0366	Alpha amylase catalytic
IUA53_RS09115	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_RS09120	COG2267	carboxylic ester hydrolase activity
IUA53_RS09130	COG0616	signal peptide processing
IUA53_RS09140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IUA53_RS09145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IUA53_RS09150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IUA53_RS09155	COG0386	Belongs to the glutathione peroxidase family
IUA53_RS09160	COG2084	Dehydrogenase
IUA53_RS09175	COG1960	acyl-CoA dehydrogenase activity
IUA53_RS09180	COG1024	Enoyl-CoA hydratase
IUA53_RS09190	COG2226	methyltransferase
IUA53_RS09195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IUA53_RS09200	COG3083	sulfuric ester hydrolase activity
IUA53_RS09205	COG3082	Protein of unknown function (DUF1414)
IUA53_RS09210	COG3081	Nucleoid-associated protein
IUA53_RS09240	COG3275	phosphorelay sensor kinase activity
IUA53_RS09245	COG3279	Response regulator of the LytR AlgR family
IUA53_RS09250	COG0205	6-phosphofructokinase activity
IUA53_RS09275	COG2205	protein histidine kinase activity
IUA53_RS09275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUA53_RS09285	COG1054	Belongs to the UPF0176 family
IUA53_RS09305	COG0513	Belongs to the DEAD box helicase family
IUA53_RS09315	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IUA53_RS09320	COG0583	DNA-binding transcription factor activity
IUA53_RS09350	COG1760	l-serine dehydratase
IUA53_RS09375	COG3706	GGDEF domain
IUA53_RS09385	COG1404	Belongs to the peptidase S8 family
IUA53_RS09395	COG0022	dehydrogenase e1 component
IUA53_RS09405	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IUA53_RS09410	COG0515	serine threonine protein kinase
IUA53_RS09415	COG1946	Acyl-CoA thioesterase
IUA53_RS09425	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IUA53_RS09435	COG1956	GAF domain-containing protein
IUA53_RS09450	COG0793	Belongs to the peptidase S41A family
IUA53_RS09455	COG0733	neurotransmitter:sodium symporter activity
IUA53_RS09460	COG1757	Na H antiporter
IUA53_RS09465	COG0308	aminopeptidase N
IUA53_RS09500	COG0167	dihydroorotate dehydrogenase activity
IUA53_RS09515	COG0488	(ABC) transporter
IUA53_RS09525	COG3130	regulation of translation
IUA53_RS09530	COG3385	transposase activity
IUA53_RS09535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IUA53_RS09545	COG0415	Belongs to the DNA photolyase family
IUA53_RS09550	COG0415	Belongs to the DNA photolyase family
IUA53_RS09555	COG0415	Belongs to the DNA photolyase family
IUA53_RS09560	COG3046	protein related to deoxyribodipyrimidine photolyase
IUA53_RS09630	COG4772	TonB-dependent receptor
IUA53_RS09685	COG0789	Transcriptional regulator
IUA53_RS09715	COG2132	Multicopper oxidase
IUA53_RS09720	COG3667	copper resistance
IUA53_RS09735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IUA53_RS09775	COG2217	Heavy metal translocating P-type atpase
IUA53_RS09780	COG0789	Transcriptional regulator
IUA53_RS09865	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUA53_RS09895	COG0745	RESPONSE REGULATOR receiver
IUA53_RS09900	COG5002	protein histidine kinase activity
IUA53_RS09960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IUA53_RS09965	COG0589	response to stress
IUA53_RS09975	COG0069	glutamate synthase activity
IUA53_RS09990	COG2193	ferroxidase activity
IUA53_RS10000	COG3278	Belongs to the heme-copper respiratory oxidase family
IUA53_RS10015	COG2010	Cytochrome c
IUA53_RS10040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IUA53_RS10045	COG0589	response to stress
IUA53_RS10050	COG0037	tRNA processing
IUA53_RS10055	COG1752	Esterase of the alpha-beta hydrolase superfamily
IUA53_RS10075	COG1280	lysine exporter protein (LysE YggA)
IUA53_RS10085	COG2897	thiosulfate sulfurtransferase activity
IUA53_RS10090	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IUA53_RS10095	COG3148	PFAM DTW domain containing protein
IUA53_RS10150	COG0582	viral genome integration into host DNA
IUA53_RS10175	COG0322	excinuclease ABC activity
IUA53_RS10180	COG2197	response regulator
IUA53_RS10185	COG1741	Belongs to the pirin family
IUA53_RS10190	COG0436	Aminotransferase
IUA53_RS10195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IUA53_RS10205	COG3384	dioxygenase
IUA53_RS10210	COG2259	Doxx family
IUA53_RS10215	COG0583	DNA-binding transcription factor activity
IUA53_RS10230	COG0670	Belongs to the BI1 family
IUA53_RS10235	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IUA53_RS10250	COG2920	part of a sulfur-relay system
IUA53_RS10255	COG0561	phosphatase activity
IUA53_RS10285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IUA53_RS10290	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IUA53_RS10295	COG0531	amino acid
IUA53_RS10295	COG1674	ftsk spoiiie
IUA53_RS10305	COG0686	Belongs to the AlaDH PNT family
IUA53_RS10310	COG0284	orotidine-5'-phosphate decarboxylase activity
IUA53_RS10315	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IUA53_RS10330	COG0776	regulation of translation
IUA53_RS10335	COG0539	negative regulation of cytoplasmic translation
IUA53_RS10340	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IUA53_RS10345	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IUA53_RS10350	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IUA53_RS10365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IUA53_RS10370	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IUA53_RS10375	COG0633	Ferredoxin
IUA53_RS10415	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IUA53_RS10420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IUA53_RS10430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IUA53_RS10445	COG4783	chaperone-mediated protein folding
IUA53_RS10450	COG4232	protein-disulfide reductase activity
IUA53_RS10455	COG1393	Belongs to the ArsC family
IUA53_RS10475	COG0789	Transcriptional regulator
IUA53_RS10505	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IUA53_RS10520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IUA53_RS10530	COG1960	acyl-CoA dehydrogenase activity
IUA53_RS10555	COG3769	mannosylglycerate metabolic process
IUA53_RS10560	COG1215	transferase activity, transferring glycosyl groups
IUA53_RS10575	COG0303	'Molybdopterin
IUA53_RS10580	COG0534	Mate efflux family protein
IUA53_RS10595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IUA53_RS10600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IUA53_RS10620	COG0405	Gamma-glutamyltransferase
IUA53_RS10625	COG1024	Enoyl-CoA hydratase
IUA53_RS10665	COG1448	Aminotransferase
IUA53_RS10675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IUA53_RS10685	COG1671	Belongs to the UPF0178 family
IUA53_RS10690	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_RS10695	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_RS10700	COG1960	acyl-CoA dehydrogenase activity
IUA53_RS10705	COG4977	sequence-specific DNA binding
IUA53_RS10755	COG0596	Alpha beta hydrolase
IUA53_RS10765	COG0716	FMN binding
IUA53_RS10775	COG0735	belongs to the Fur family
IUA53_RS10785	COG1984	allophanate hydrolase subunit 2
IUA53_RS10795	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IUA53_RS10800	COG2996	Protein conserved in bacteria
IUA53_RS10805	COG1765	OsmC-like protein
IUA53_RS10820	COG0436	Aminotransferase
IUA53_RS10825	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IUA53_RS10845	COG4771	TonB-dependent receptor
IUA53_RS10850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IUA53_RS10860	COG1238	metal cluster binding
IUA53_RS10870	COG3012	SEC-C Motif Domain Protein
IUA53_RS10885	COG0456	acetyltransferase
IUA53_RS10890	COG3706	GGDEF domain
IUA53_RS10895	COG0702	epimerase
IUA53_RS10905	COG0084	hydrolase, TatD family'
IUA53_RS10920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IUA53_RS10925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IUA53_RS10930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IUA53_RS10935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IUA53_RS10950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IUA53_RS10955	COG0416	fatty acid biosynthetic process
IUA53_RS10965	COG1399	metal-binding, possibly nucleic acid-binding protein
IUA53_RS10975	COG0546	phosphoglycolate phosphatase activity
IUA53_RS10980	COG0564	pseudouridine synthase activity
IUA53_RS10985	COG1530	ribonuclease E activity
IUA53_RS11000	COG2153	protein acetylation
IUA53_RS11005	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IUA53_RS11010	COG3122	Protein conserved in bacteria
IUA53_RS11015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IUA53_RS11020	COG3724	N-succinylarginine dihydrolase activity
IUA53_RS11035	COG4591	ABC-type transport system involved in lipoprotein release permease component
IUA53_RS11040	COG1136	(ABC) transporter
IUA53_RS11045	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IUA53_RS11080	COG0328	RNA-DNA hybrid ribonuclease activity
IUA53_RS11085	COG3321	synthase
IUA53_RS11085	COG0604	alcohol dehydrogenase
IUA53_RS11105	COG1643	Atp-dependent helicase
IUA53_RS11145	COG2925	Exonuclease
IUA53_RS11160	COG0183	Belongs to the thiolase family
IUA53_RS11165	COG0789	Transcriptional regulator
IUA53_RS11170	COG1960	acyl-CoA dehydrogenase activity
IUA53_RS11175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IUA53_RS11185	COG4770	biotin carboxylase activity
IUA53_RS11215	COG2814	Major facilitator Superfamily
IUA53_RS11250	COG0708	Exodeoxyribonuclease III
IUA53_RS11260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IUA53_RS11265	COG4591	ABC-type transport system involved in lipoprotein release permease component
IUA53_RS11275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IUA53_RS11285	COG2096	Adenosyltransferase
IUA53_RS11290	COG1472	Belongs to the glycosyl hydrolase 3 family
IUA53_RS11315	COG0072	phenylalanine-tRNA ligase activity
IUA53_RS11315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IUA53_RS11325	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IUA53_RS11325	COG2755	lipolytic protein G-D-S-L family
IUA53_RS11365	COG0438	transferase activity, transferring glycosyl groups
IUA53_RS11380	COG2755	lipolytic protein G-D-S-L family
IUA53_RS11380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IUA53_RS11405	COG3300	MHYT domain
IUA53_RS11405	COG5001	Diguanylate cyclase
IUA53_RS11420	COG0438	transferase activity, transferring glycosyl groups
IUA53_RS11435	COG0489	protein tyrosine kinase activity
IUA53_RS11440	COG1596	polysaccharide export
IUA53_RS11450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IUA53_RS11465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IUA53_RS11475	COG3001	Fructosamine kinase
IUA53_RS11480	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_RS11520	COG0730	response to heat
IUA53_RS11525	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IUA53_RS11545	COG2233	PERMEase
IUA53_RS11570	COG0784	Response regulator, receiver
IUA53_RS11570	COG2205	protein histidine kinase activity
IUA53_RS11580	COG5001	Diguanylate cyclase
IUA53_RS11580	COG3300	MHYT domain
IUA53_RS11590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IUA53_RS11595	COG2252	PERMEase
IUA53_RS11610	COG1309	transcriptional regulator
IUA53_RS11620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IUA53_RS11635	COG2351	hydroxyisourate hydrolase activity
IUA53_RS11640	COG0402	S-adenosylhomocysteine deaminase activity
IUA53_RS11650	COG3447	MASE1 domain protein
IUA53_RS11650	COG5002	protein histidine kinase activity
IUA53_RS11650	COG5001	Diguanylate cyclase
IUA53_RS11675	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IUA53_RS11700	COG1393	Belongs to the ArsC family
IUA53_RS11730	COG2988	succinylglutamate desuccinylase activity
IUA53_RS11740	COG0058	SHG alpha-glucan phosphorylase activity
IUA53_RS11745	COG0033	Phosphoglucomutase
IUA53_RS11750	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IUA53_RS11755	COG2116	formate transmembrane transporter activity
IUA53_RS11760	COG2815	serine threonine protein kinase
IUA53_RS11760	COG0515	serine threonine protein kinase
IUA53_RS11765	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
IUA53_RS11775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IUA53_RS11785	COG2363	Small membrane protein
IUA53_RS11795	COG0583	DNA-binding transcription factor activity
IUA53_RS11805	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IUA53_RS11815	COG3437	response regulator, receiver
IUA53_RS11815	COG0784	Response regulator, receiver
IUA53_RS11820	COG2890	protein-(glutamine-N5) methyltransferase activity
IUA53_RS11830	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IUA53_RS11835	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IUA53_RS11840	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IUA53_RS11850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IUA53_RS11875	COG0012	GTP binding
IUA53_RS11935	COG1115	amino acid carrier protein
IUA53_RS11940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IUA53_RS11945	COG1607	acyl-coa hydrolase
IUA53_RS11970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IUA53_RS11980	COG1702	phosphate starvation-inducible protein PhoH
IUA53_RS12000	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IUA53_RS12005	COG4535	Mg2 and Co2 transporter CorC
IUA53_RS12010	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IUA53_RS12015	COG0857	belongs to the CobB CobQ family
IUA53_RS12015	COG0280	phosphate acetyltransferase
IUA53_RS12025	COG0071	Belongs to the small heat shock protein (HSP20) family
IUA53_RS12035	COG0840	transmembrane signaling receptor activity
IUA53_RS12040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IUA53_RS12045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IUA53_RS12055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IUA53_RS12065	COG3300	MHYT domain
IUA53_RS12065	COG5001	Diguanylate cyclase
IUA53_RS12070	COG3909	cytochrome
IUA53_RS12075	COG0484	heat shock protein binding
IUA53_RS12085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IUA53_RS12090	COG2202	Pas domain
IUA53_RS12090	COG2205	protein histidine kinase activity
IUA53_RS12105	COG4771	TonB-dependent receptor
IUA53_RS12110	COG2610	gluconate transmembrane transporter activity
IUA53_RS12115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IUA53_RS12125	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_RS12130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IUA53_RS12135	COG0783	Belongs to the Dps family
IUA53_RS12145	COG0497	DNA recombination
IUA53_RS12150	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUA53_RS12155	COG0500	methyltransferase
IUA53_RS12160	COG2733	membrane
IUA53_RS12175	COG0110	maltose O-acetyltransferase activity
IUA53_RS12180	COG0656	L-ascorbic acid biosynthetic process
IUA53_RS12190	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IUA53_RS12195	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IUA53_RS12200	COG0009	L-threonylcarbamoyladenylate synthase
IUA53_RS12205	COG0613	PHP domain protein
IUA53_RS12210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IUA53_RS12220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IUA53_RS12225	COG0134	indole-3-glycerol-phosphate synthase activity
IUA53_RS12225	COG0135	phosphoribosylanthranilate isomerase activity
IUA53_RS12235	COG0159	tryptophan synthase activity
IUA53_RS12240	COG2350	Protein conserved in bacteria
IUA53_RS12265	COG0628	permease
IUA53_RS12270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IUA53_RS12275	COG1090	epimerase
IUA53_RS12280	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IUA53_RS12285	COG4181	ATPase activity
IUA53_RS12290	COG2755	lipolytic protein G-D-S-L family
IUA53_RS12310	COG0402	S-adenosylhomocysteine deaminase activity
IUA53_RS12315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IUA53_RS12360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IUA53_RS12390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IUA53_RS12395	COG5265	(ABC) transporter
IUA53_RS12410	COG2972	Histidine kinase
IUA53_RS12415	COG1131	(ABC) transporter
IUA53_RS12425	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IUA53_RS12430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IUA53_RS12435	COG3340	Belongs to the peptidase S51 family
IUA53_RS12445	COG1073	alpha beta
IUA53_RS12445	COG2226	methyltransferase
IUA53_RS12480	COG0189	ligase activity
IUA53_RS12495	COG0017	Asparaginyl-tRNA synthetase
IUA53_RS12500	COG1505	serine-type exopeptidase activity
IUA53_RS12510	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
IUA53_RS12530	COG3093	addiction module antidote protein HigA
IUA53_RS12550	COG2995	paraquat-inducible protein a
IUA53_RS12555	COG3008	intermembrane lipid transfer
IUA53_RS12555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IUA53_RS12600	COG3321	synthase
IUA53_RS12600	COG0604	alcohol dehydrogenase
IUA53_RS12600	COG4221	oxidoreductase activity
IUA53_RS12600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IUA53_RS12605	COG0583	DNA-binding transcription factor activity
IUA53_RS12610	COG3038	cytochrome b561
IUA53_RS12615	COG0753	catalase activity
IUA53_RS12620	COG4221	oxidoreductase activity
IUA53_RS12625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IUA53_RS12645	COG0612	Peptidase, M16
IUA53_RS12650	COG4667	esterase of the alpha-beta hydrolase superfamily
IUA53_RS12655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUA53_RS12685	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_RS12695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IUA53_RS12725	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IUA53_RS12730	COG2885	chlorophyll binding
IUA53_RS12735	COG0823	Involved in the tonB-independent uptake of proteins
IUA53_RS12750	COG0811	peptide transport
IUA53_RS12755	COG0824	Thioesterase
IUA53_RS12760	COG2255	four-way junction helicase activity
IUA53_RS12765	COG0632	four-way junction helicase activity
IUA53_RS12770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IUA53_RS12775	COG0494	nUDIX hydrolase
IUA53_RS12780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IUA53_RS12785	COG1801	Protein of unknown function DUF72
IUA53_RS12790	COG2204	response regulator
IUA53_RS12800	COG2205	protein histidine kinase activity
IUA53_RS12830	COG0023	Translation Initiation Factor
IUA53_RS12835	COG0745	RESPONSE REGULATOR receiver
IUA53_RS12840	COG0077	Prephenate dehydratase
IUA53_RS12840	COG1605	Chorismate mutase
IUA53_RS12845	COG1605	Chorismate mutase
IUA53_RS12845	COG0287	Prephenate dehydrogenase
IUA53_RS12850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IUA53_RS12860	COG2860	membrane
IUA53_RS12865	COG0335	large ribosomal subunit rRNA binding
IUA53_RS12870	COG0336	Belongs to the RNA methyltransferase TrmD family
IUA53_RS12875	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IUA53_RS12880	COG0228	four-way junction DNA binding
IUA53_RS12895	COG2873	o-acetylhomoserine
IUA53_RS12900	COG1132	(ABC) transporter
IUA53_RS12905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUA53_RS12945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IUA53_RS12950	COG4137	Cytochrome C assembly protein
IUA53_RS12955	COG4536	flavin adenine dinucleotide binding
IUA53_RS12965	COG2062	phosphohistidine phosphatase, SixA
IUA53_RS12970	COG1025	Belongs to the peptidase M16 family
IUA53_RS12990	COG1024	Enoyl-CoA hydratase
IUA53_RS12990	COG1250	3-hydroxyacyl-CoA dehydrogenase
IUA53_RS13000	COG0714	Associated with various cellular activities
IUA53_RS13020	COG2304	oxidoreductase activity
IUA53_RS13035	COG1595	DNA-templated transcription, initiation
IUA53_RS13050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IUA53_RS13055	COG0175	sulfate reduction
IUA53_RS13060	COG0529	Catalyzes the synthesis of activated sulfate
IUA53_RS13075	COG3273	potassium ion transport
IUA53_RS13075	COG0471	metal ion transport
IUA53_RS13100	COG0367	asparagine synthase
IUA53_RS13110	COG0602	queuosine metabolic process
IUA53_RS13135	COG0556	nucleotide-excision repair
IUA53_RS13140	COG0534	Mate efflux family protein
IUA53_RS13155	COG4657	Part of a membrane complex involved in electron transport
IUA53_RS13160	COG2878	Part of a membrane complex involved in electron transport
IUA53_RS13165	COG4656	Part of a membrane complex involved in electron transport
IUA53_RS13170	COG4658	electron transport chain
IUA53_RS13175	COG4659	FMN binding
IUA53_RS13180	COG4660	Part of a membrane complex involved in electron transport
IUA53_RS13185	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IUA53_RS13190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IUA53_RS13200	COG0583	DNA-binding transcription factor activity
IUA53_RS13240	COG3547	Transposase (IS116 IS110 IS902 family)
IUA53_RS13280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IUA53_RS13330	COG3710	Transcriptional regulator
IUA53_RS13345	COG3706	GGDEF domain
IUA53_RS13350	COG1278	Cold shock
IUA53_RS13355	COG0346	lactoylglutathione lyase activity
IUA53_RS13360	COG0584	glycerophosphoryl diester phosphodiesterase
IUA53_RS13365	COG2885	chlorophyll binding
IUA53_RS13370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IUA53_RS13395	COG4771	TonB-dependent receptor
IUA53_RS13400	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IUA53_RS13405	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IUA53_RS13410	COG2766	serine protein kinase
IUA53_RS13415	COG2718	Belongs to the UPF0229 family
IUA53_RS13420	COG2719	SpoVR family
IUA53_RS13440	COG2890	protein-(glutamine-N5) methyltransferase activity
IUA53_RS13445	COG2840	Smr protein MutS2
IUA53_RS13465	COG0577	efflux transmembrane transporter activity
IUA53_RS13465	COG1136	(ABC) transporter
IUA53_RS13475	COG1136	(ABC) transporter
IUA53_RS13480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUA53_RS13490	COG2918	glutathione biosynthetic process
IUA53_RS13495	COG0612	Peptidase, M16
IUA53_RS13505	COG0564	pseudouridine synthase activity
IUA53_RS13510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IUA53_RS13515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IUA53_RS13525	COG0572	uridine kinase
IUA53_RS13565	COG1196	nuclear chromosome segregation
IUA53_RS13575	COG0633	Ferredoxin
IUA53_RS13575	COG0543	2 iron, 2 sulfur cluster binding
IUA53_RS13595	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IUA53_RS13690	COG0583	DNA-binding transcription factor activity
IUA53_RS13710	COG2003	Belongs to the UPF0758 family
IUA53_RS13735	COG0714	Associated with various cellular activities
IUA53_RS13755	COG0629	single-stranded DNA binding
IUA53_RS13770	COG0464	growth
IUA53_RS13775	COG1404	Belongs to the peptidase S8 family
IUA53_RS13785	COG1074	ATP-dependent DNA helicase activity
IUA53_RS13805	COG0681	Belongs to the peptidase S26 family
IUA53_RS13820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IUA53_RS13840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUA53_RS13895	COG1230	cation diffusion facilitator family transporter
IUA53_RS13905	COG0640	Transcriptional regulator
IUA53_RS13915	COG0789	Transcriptional regulator
IUA53_RS13925	COG0789	Transcriptional regulator
IUA53_RS13970	COG1484	DNA-dependent DNA replication
IUA53_RS14070	COG3474	cytochrome
IUA53_RS14080	COG4771	TonB-dependent receptor
IUA53_RS14095	COG3119	arylsulfatase activity
IUA53_RS14100	COG2814	Major facilitator Superfamily
IUA53_RS14105	COG1404	Belongs to the peptidase S8 family
IUA53_RS14110	COG1132	(ABC) transporter
IUA53_RS14125	COG0318	PFAM AMP-dependent synthetase and ligase
IUA53_RS14150	COG1012	belongs to the aldehyde dehydrogenase family
IUA53_RS14170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IUA53_RS14300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IUA53_RS14325	COG1484	DNA-dependent DNA replication
IUA53_RS14330	COG4584	PFAM Integrase catalytic
IUA53_RS14365	COG4584	PFAM Integrase catalytic
IUA53_RS14375	COG0668	transmembrane transport
IUA53_RS14410	COG3550	peptidyl-serine autophosphorylation
IUA53_RS14415	COG3620	sequence-specific DNA binding
IUA53_RS14420	COG3706	GGDEF domain
IUA53_RS14430	COG2814	Major facilitator Superfamily
IUA53_RS14435	COG0583	DNA-binding transcription factor activity
IUA53_RS14450	COG0456	acetyltransferase
IUA53_RS14490	COG1444	tRNA N-acetyltransferase activity
IUA53_RS14505	COG0848	biopolymer transport protein
IUA53_RS14510	COG0811	peptide transport
IUA53_RS14515	COG0811	peptide transport
IUA53_RS14550	COG1522	sequence-specific DNA binding
IUA53_RS14555	COG0625	glutathione transferase activity
IUA53_RS14585	COG1842	Phage shock protein A
IUA53_RS14590	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IUA53_RS14595	COG0747	negative chemotaxis
IUA53_RS14600	COG0601	transmembrane transport
IUA53_RS14605	COG4171	peptide transport system, permease
IUA53_RS14610	COG4172	Belongs to the ABC transporter superfamily
IUA53_RS14615	COG4172	Belongs to the ABC transporter superfamily
IUA53_RS14620	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IUA53_RS14655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IUA53_RS14660	COG2137	regulation of response to DNA damage stimulus
IUA53_RS14675	COG0659	secondary active sulfate transmembrane transporter activity
IUA53_RS14680	COG0288	reversible hydration of carbon dioxide
IUA53_RS14685	COG0583	DNA-binding transcription factor activity
IUA53_RS14690	COG0583	DNA-binding transcription factor activity
IUA53_RS14695	COG3123	guanosine phosphorylase activity
IUA53_RS14710	COG1410	methionine synthase
IUA53_RS14710	COG0646	methionine synthase
IUA53_RS14715	COG0646	methionine synthase
IUA53_RS14715	COG1410	methionine synthase
IUA53_RS14730	COG0835	chemotaxis
IUA53_RS14740	COG1192	Involved in chromosome partitioning
IUA53_RS14745	COG2201	protein-glutamate methylesterase activity
IUA53_RS14750	COG0784	Response regulator, receiver
IUA53_RS14750	COG2198	Histidine kinase
IUA53_RS14750	COG0643	Histidine kinase
IUA53_RS14755	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IUA53_RS14780	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IUA53_RS14795	COG1987	bacterial-type flagellum assembly
IUA53_RS14855	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IUA53_RS14860	COG1766	The M ring may be actively involved in energy transduction
IUA53_RS14865	COG1677	Flagellar hook-basal body complex protein FliE
IUA53_RS14895	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IUA53_RS14935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IUA53_RS14940	COG3475	LICD family
IUA53_RS14945	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IUA53_RS14950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IUA53_RS15005	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_RS15025	COG2089	acid synthase
IUA53_RS15030	COG1083	cytidylyl-transferase
IUA53_RS15035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IUA53_RS15040	COG1086	Polysaccharide biosynthesis protein
IUA53_RS15050	COG1516	flagellar protein fliS
IUA53_RS15060	COG1334	flagellar protein FlaG
IUA53_RS15065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IUA53_RS15070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IUA53_RS15090	COG1256	bacterial-type flagellum assembly
IUA53_RS15095	COG1705	Flagellar rod assembly protein muramidase FlgJ
IUA53_RS15095	COG3951	Flagellar rod assembly protein muramidase FlgJ
IUA53_RS15115	COG4787	bacterial-type flagellum-dependent cell motility
IUA53_RS15135	COG1815	bacterial-type flagellum-dependent cell motility
IUA53_RS15140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IUA53_RS15145	COG0835	chemotaxis
IUA53_RS15145	COG0784	Response regulator, receiver
IUA53_RS15180	COG2840	Smr protein MutS2
IUA53_RS15190	COG0047	phosphoribosylformylglycinamidine synthase activity
IUA53_RS15190	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IUA53_RS15220	COG0037	tRNA processing
IUA53_RS15225	COG0825	malonyl-CoA metabolic process
IUA53_RS15230	COG0587	DNA-directed DNA polymerase activity
IUA53_RS15245	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IUA53_RS15250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IUA53_RS15265	COG0750	zinc metalloprotease
IUA53_RS15275	COG0575	Belongs to the CDS family
IUA53_RS15280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IUA53_RS15290	COG0528	UMP kinase activity
IUA53_RS15300	COG0052	Belongs to the universal ribosomal protein uS2 family
IUA53_RS15305	COG0024	Methionine aminopeptidase
IUA53_RS15310	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IUA53_RS15325	COG0564	pseudouridine synthase activity
IUA53_RS15385	COG1484	DNA-dependent DNA replication
IUA53_RS15415	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IUA53_RS15415	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IUA53_RS15425	COG1611	Belongs to the LOG family
IUA53_RS15440	COG0473	3-isopropylmalate dehydrogenase activity
IUA53_RS15445	COG1555	photosystem II stabilization
IUA53_RS15445	COG1596	polysaccharide export
IUA53_RS15450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IUA53_RS15465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IUA53_RS15505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IUA53_RS15510	COG2853	Lipoprotein
IUA53_RS15525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IUA53_RS15530	COG1138	Cytochrome C-type biogenesis protein
IUA53_RS15540	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IUA53_RS15545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IUA53_RS15550	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IUA53_RS15555	COG4133	protoheme IX ABC transporter activity
IUA53_RS15570	COG1668	transmembrane transport
IUA53_RS15575	COG4555	ABC transporter
IUA53_RS15595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IUA53_RS15620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IUA53_RS15625	COG0473	3-isopropylmalate dehydrogenase activity
IUA53_RS15635	COG0066	3-isopropylmalate dehydratase activity
IUA53_RS15650	COG3409	Peptidoglycan-binding domain 1 protein
IUA53_RS15650	COG3267	Type II secretory pathway component ExeA
IUA53_RS15660	COG0513	Belongs to the DEAD box helicase family
IUA53_RS15665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IUA53_RS15670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IUA53_RS15700	COG1346	cytolysis
IUA53_RS15705	COG1380	Effector of murein hydrolase LrgA
IUA53_RS15780	COG0840	transmembrane signaling receptor activity
IUA53_RS15785	COG3588	fructose-bisphosphate aldolase
IUA53_RS15815	COG3842	ATPase activity
IUA53_RS15820	COG3842	ATPase activity
IUA53_RS15825	COG3284	Transcriptional regulator
IUA53_RS15830	COG0149	triose-phosphate isomerase activity
IUA53_RS15835	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IUA53_RS15840	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IUA53_RS15850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IUA53_RS15855	COG3842	ATPase activity
IUA53_RS15905	COG0668	transmembrane transport
IUA53_RS15910	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IUA53_RS15925	COG0488	(ABC) transporter
IUA53_RS15935	COG2971	BadF BadG BcrA BcrD
IUA53_RS15955	COG0625	glutathione transferase activity
IUA53_RS16010	COG2801	Transposase and inactivated derivatives
IUA53_RS16015	COG2801	Transposase and inactivated derivatives
IUA53_RS16020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IUA53_RS16030	COG0419	ATPase involved in DNA repair
IUA53_RS16035	COG0420	3'-5' exonuclease activity
IUA53_RS16045	COG1739	Uncharacterized protein family UPF0029
IUA53_RS16055	COG1764	response to oxidative stress
IUA53_RS16060	COG1846	Transcriptional regulator
IUA53_RS16065	COG1272	protein, Hemolysin III
IUA53_RS16075	COG0583	DNA-binding transcription factor activity
IUA53_RS16080	COG0589	response to stress
IUA53_RS16085	COG0306	phosphate transporter
IUA53_RS16095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IUA53_RS16105	COG0573	inorganic phosphate transmembrane transporter activity
IUA53_RS16115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IUA53_RS16120	COG0248	Ppx GppA phosphatase
IUA53_RS16125	COG3588	fructose-bisphosphate aldolase
IUA53_RS16130	COG0126	phosphoglycerate kinase activity
IUA53_RS16140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IUA53_RS16165	COG1979	alcohol dehydrogenase
IUA53_RS16180	COG2205	protein histidine kinase activity
IUA53_RS16180	COG0784	Response regulator, receiver
IUA53_RS16195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IUA53_RS16245	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IUA53_RS16255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IUA53_RS16260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IUA53_RS16275	COG5007	Belongs to the BolA IbaG family
IUA53_RS16285	COG2854	intermembrane phospholipid transfer
IUA53_RS16290	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IUA53_RS16295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IUA53_RS16300	COG1127	ABC transporter
IUA53_RS16315	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IUA53_RS16330	COG1137	ATPase activity
IUA53_RS16335	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IUA53_RS16355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IUA53_RS16360	COG2239	Acts as a magnesium transporter
IUA53_RS16365	COG0745	RESPONSE REGULATOR receiver
IUA53_RS16380	COG2969	positive regulation of protein catabolic process
IUA53_RS16385	COG0625	glutathione transferase activity
IUA53_RS16390	COG2857	Cytochrome c1
IUA53_RS16395	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IUA53_RS16400	COG0723	plastoquinol--plastocyanin reductase activity
IUA53_RS16410	COG4206	TonB-dependent receptor
IUA53_RS16420	COG1595	DNA-templated transcription, initiation
IUA53_RS16425	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IUA53_RS16440	COG3956	TIGRFAM MazG family protein
IUA53_RS16445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IUA53_RS16450	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IUA53_RS16460	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IUA53_RS16475	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IUA53_RS16480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IUA53_RS16490	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IUA53_RS16500	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IUA53_RS16505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IUA53_RS16510	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IUA53_RS16515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IUA53_RS16520	COG2967	ApaG domain
IUA53_RS16525	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IUA53_RS16530	COG0840	transmembrane signaling receptor activity
IUA53_RS16535	COG0527	aspartate kinase activity
IUA53_RS16550	COG1793	dna ligase
IUA53_RS16560	COG1049	propionate catabolic process, 2-methylcitrate cycle
IUA53_RS16565	COG2133	pyrroloquinoline quinone binding
IUA53_RS16580	COG0784	Response regulator, receiver
IUA53_RS16580	COG2205	protein histidine kinase activity
IUA53_RS16580	COG5002	protein histidine kinase activity
IUA53_RS16585	COG3437	response regulator, receiver
IUA53_RS16590	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IUA53_RS16600	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IUA53_RS16605	COG0848	biopolymer transport protein
IUA53_RS16610	COG0811	peptide transport
IUA53_RS16615	COG0811	peptide transport
IUA53_RS16645	COG5002	protein histidine kinase activity
IUA53_RS16650	COG0745	RESPONSE REGULATOR receiver
IUA53_RS16655	COG4191	Histidine kinase
IUA53_RS16655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUA53_RS16660	COG2974	May be involved in recombination
IUA53_RS16665	COG1396	sequence-specific DNA binding
IUA53_RS16670	COG3135	benzoate transporter
IUA53_RS16685	COG0537	adenosine 5'-monophosphoramidase activity
IUA53_RS16705	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IUA53_RS16725	COG0358	DNA primase activity
IUA53_RS16760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUA53_RS16780	COG4948	Mandelate Racemase Muconate Lactonizing
IUA53_RS16790	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_RS16795	COG1960	acyl-CoA dehydrogenase activity
IUA53_RS16810	COG0348	domain, Protein
IUA53_RS16815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IUA53_RS16820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IUA53_RS16830	COG0746	molybdenum cofactor guanylyltransferase activity
IUA53_RS16840	COG1116	anion transmembrane transporter activity
IUA53_RS16845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IUA53_RS16850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IUA53_RS16850	COG1116	anion transmembrane transporter activity
IUA53_RS16860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IUA53_RS16865	COG1648	precorrin-2 dehydrogenase activity
IUA53_RS16865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IUA53_RS16870	COG0243	molybdopterin cofactor binding
IUA53_RS16875	COG2146	nitrite reductase [NAD(P)H] activity
IUA53_RS16880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IUA53_RS16885	COG0659	secondary active sulfate transmembrane transporter activity
IUA53_RS16895	COG3707	response regulator
IUA53_RS16905	COG0671	phosphoesterase, PA-phosphatase related
IUA53_RS16910	COG0271	Belongs to the BolA IbaG family
IUA53_RS16925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IUA53_RS16940	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IUA53_RS16945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IUA53_RS16950	COG1509	lysine 2,3-aminomutase activity
IUA53_RS16970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUA53_RS16975	COG4251	negative regulation of phosphorylation
IUA53_RS16985	COG0187	DNA topoisomerase II activity
IUA53_RS16990	COG3150	esterase
IUA53_RS17000	COG3151	Protein conserved in bacteria
IUA53_RS17005	COG0494	nUDIX hydrolase
IUA53_RS17010	COG1538	Outer membrane efflux protein
IUA53_RS17035	COG1648	precorrin-2 dehydrogenase activity
IUA53_RS17035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IUA53_RS17045	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IUA53_RS17055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IUA53_RS17060	COG0564	pseudouridine synthase activity
IUA53_RS17080	COG2205	protein histidine kinase activity
IUA53_RS17080	COG0784	Response regulator, receiver
IUA53_RS17085	COG3706	GGDEF domain
IUA53_RS17095	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IUA53_RS17100	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IUA53_RS17105	COG0730	response to heat
IUA53_RS17115	COG0494	nUDIX hydrolase
IUA53_RS17120	COG3066	DNA modification
IUA53_RS17130	COG3025	triphosphatase activity
IUA53_RS17160	COG1538	Outer membrane efflux protein
IUA53_RS17170	COG0840	transmembrane signaling receptor activity
IUA53_RS17180	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IUA53_RS17195	COG0585	pseudouridine synthase activity
IUA53_RS17200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IUA53_RS17210	COG1238	metal cluster binding
IUA53_RS17215	COG4942	peptidase
IUA53_RS17215	COG1388	LysM domain
IUA53_RS17220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IUA53_RS17270	COG0142	geranyltranstransferase activity
IUA53_RS17280	COG0006	proline dipeptidase activity
IUA53_RS17285	COG0741	lytic transglycosylase activity
IUA53_RS17290	COG1024	Enoyl-CoA hydratase
IUA53_RS17290	COG1250	3-hydroxyacyl-CoA dehydrogenase
IUA53_RS17295	COG0183	Belongs to the thiolase family
IUA53_RS17385	COG1228	amidohydrolase
IUA53_RS17425	COG0519	Catalyzes the synthesis of GMP from XMP
IUA53_RS17530	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IUA53_RS17535	COG3876	Protein conserved in bacteria
IUA53_RS17550	COG1757	Na H antiporter
IUA53_RS17560	COG1012	belongs to the aldehyde dehydrogenase family
IUA53_RS17570	COG3118	belongs to the thioredoxin family
IUA53_RS17580	COG0823	Involved in the tonB-independent uptake of proteins
IUA53_RS17580	COG4946	Tricorn protease homolog
IUA53_RS17580	COG1506	peptidase
IUA53_RS17585	COG2133	pyrroloquinoline quinone binding
IUA53_RS17590	COG0783	Belongs to the Dps family
IUA53_RS17605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IUA53_RS17610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IUA53_RS17615	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IUA53_RS17620	COG0784	Response regulator, receiver
IUA53_RS17620	COG2205	protein histidine kinase activity
IUA53_RS17625	COG1473	amidohydrolase
IUA53_RS17630	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IUA53_RS17635	COG3118	belongs to the thioredoxin family
IUA53_RS17640	COG0513	Belongs to the DEAD box helicase family
IUA53_RS17645	COG0248	Ppx GppA phosphatase
IUA53_RS17655	COG3706	GGDEF domain
IUA53_RS17670	COG0805	protein transport
IUA53_RS17675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IUA53_RS17695	COG0028	Belongs to the TPP enzyme family
IUA53_RS17725	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IUA53_RS17730	COG1162	GTPase activity
IUA53_RS17755	COG2861	carbohydrate metabolic process
IUA53_RS17765	COG4942	peptidase
IUA53_RS17770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IUA53_RS17775	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IUA53_RS17785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IUA53_RS17795	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IUA53_RS17800	COG2267	carboxylic ester hydrolase activity
IUA53_RS17805	COG2205	protein histidine kinase activity
IUA53_RS17810	COG0745	RESPONSE REGULATOR receiver
IUA53_RS17825	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IUA53_RS17835	COG1803	Methylglyoxal synthase
IUA53_RS17855	COG0137	argininosuccinate synthase activity
IUA53_RS17865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IUA53_RS17865	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IUA53_RS17870	COG5001	Diguanylate cyclase
IUA53_RS17870	COG3300	MHYT domain
IUA53_RS17890	COG0753	catalase activity
IUA53_RS17895	COG0625	glutathione transferase activity
IUA53_RS17900	COG0281	malic enzyme
IUA53_RS17905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IUA53_RS17940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IUA53_RS17950	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IUA53_RS17970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IUA53_RS17975	COG0180	Tryptophanyl-tRNA synthetase
IUA53_RS17980	COG0512	Glutamine amidotransferase of anthranilate synthase
IUA53_RS17990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IUA53_RS18000	COG1012	belongs to the aldehyde dehydrogenase family
IUA53_RS18010	COG3300	MHYT domain
IUA53_RS18010	COG5001	Diguanylate cyclase
IUA53_RS18050	COG0540	Belongs to the ATCase OTCase family
IUA53_RS18060	COG2837	iron assimilation
IUA53_RS18065	COG0405	Gamma-glutamyltransferase
IUA53_RS18070	COG0004	ammonium transporteR
IUA53_RS18090	COG2169	Transcriptional regulator
IUA53_RS18095	COG2354	Protein conserved in bacteria
IUA53_RS18105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IUA53_RS18115	COG2951	lytic endotransglycosylase activity
IUA53_RS18120	COG1643	Atp-dependent helicase
IUA53_RS18135	COG0788	formyltetrahydrofolate deformylase activity
IUA53_RS18170	COG1519	Transferase
IUA53_RS18180	COG0438	transferase activity, transferring glycosyl groups
IUA53_RS18185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IUA53_RS18200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IUA53_RS18210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IUA53_RS18220	COG0089	rRNA binding
IUA53_RS18235	COG0051	transcription antitermination factor activity, RNA binding
IUA53_RS18240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IUA53_RS18295	COG0302	gtp cyclohydrolase
IUA53_RS18305	COG2957	Belongs to the agmatine deiminase family
IUA53_RS18310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IUA53_RS18320	COG3706	GGDEF domain
IUA53_RS18330	COG2207	Transcriptional regulator
IUA53_RS18335	COG1073	alpha beta
IUA53_RS18385	COG1201	RNA secondary structure unwinding
IUA53_RS18395	COG1793	dna ligase
IUA53_RS18415	COG0625	glutathione transferase activity
IUA53_RS18425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IUA53_RS18435	COG1012	belongs to the aldehyde dehydrogenase family
IUA53_RS18440	COG0028	Belongs to the TPP enzyme family
IUA53_RS18450	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IUA53_RS18465	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IUA53_RS18470	COG0330	HflC and HflK could
IUA53_RS18475	COG0330	HflC and HflK could
IUA53_RS18480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IUA53_RS18485	COG1923	regulation of RNA biosynthetic process
IUA53_RS18490	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IUA53_RS18495	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IUA53_RS18505	COG0802	atpase or kinase
IUA53_RS18510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IUA53_RS18510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IUA53_RS18515	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IUA53_RS18535	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IUA53_RS18540	COG0735	belongs to the Fur family
IUA53_RS18550	COG0432	Pfam Uncharacterised protein family UPF0047
IUA53_RS18560	COG0305	Participates in initiation and elongation during chromosome replication
IUA53_RS18585	COG2258	MOSC domain
IUA53_RS18615	COG0840	transmembrane signaling receptor activity
IUA53_RS18620	COG4191	Histidine kinase
IUA53_RS18630	COG1609	Transcriptional regulator
IUA53_RS18635	COG2211	Major facilitator Superfamily
IUA53_RS18640	COG2723	6-phospho-beta-galactosidase activity
IUA53_RS18655	COG0789	Transcriptional regulator
IUA53_RS18660	COG0655	NAD(P)H dehydrogenase (quinone) activity
IUA53_RS18670	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IUA53_RS18675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IUA53_RS18680	COG4558	Periplasmic binding protein
IUA53_RS18690	COG4771	TonB-dependent receptor
IUA53_RS18715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IUA53_RS18720	COG4988	ABC transporter
IUA53_RS18725	COG4890	Cyd operon protein YbgT
IUA53_RS18730	COG1294	oxidase, subunit
IUA53_RS18745	COG2204	response regulator
IUA53_RS18790	COG1136	(ABC) transporter
IUA53_RS18830	COG2814	Major facilitator Superfamily
IUA53_RS18840	COG3237	CsbD-like
IUA53_RS18855	COG4771	TonB-dependent receptor
IUA53_RS18860	COG0457	Tetratricopeptide repeat
IUA53_RS18875	COG3314	Sporulation integral membrane protein YlbJ
IUA53_RS18880	COG4638	Rieske (2fe-2S)
IUA53_RS18890	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IUA53_RS18940	COG1595	DNA-templated transcription, initiation
IUA53_RS18970	COG2267	carboxylic ester hydrolase activity
IUA53_RS18990	COG1252	NADH dehydrogenase
IUA53_RS19010	COG0583	DNA-binding transcription factor activity
IUA53_RS19015	COG2067	long-chain fatty acid transport protein
IUA53_RS19020	COG2130	NADP-dependent
IUA53_RS19030	COG0784	Response regulator, receiver
IUA53_RS19030	COG2205	protein histidine kinase activity
IUA53_RS19040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IUA53_RS19050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IUA53_RS19055	COG4771	TonB-dependent receptor
IUA53_RS19060	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IUA53_RS19080	COG0656	L-ascorbic acid biosynthetic process
IUA53_RS19085	COG2175	clavaminate synthase activity
IUA53_RS19090	COG2855	membrane
IUA53_RS19120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IUA53_RS19125	COG1349	DNA-binding transcription factor activity
IUA53_RS19130	COG0673	inositol 2-dehydrogenase activity
IUA53_RS19145	COG0697	spore germination
IUA53_RS19155	COG2169	Transcriptional regulator
IUA53_RS19165	COG1166	arginine decarboxylase activity
IUA53_RS19175	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IUA53_RS19215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IUA53_RS19220	COG3507	Belongs to the glycosyl hydrolase 43 family
IUA53_RS19230	COG0109	protoheme IX farnesyltransferase activity
IUA53_RS19250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IUA53_RS19265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IUA53_RS19295	COG1335	isochorismatase
IUA53_RS19300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IUA53_RS19315	COG3384	dioxygenase
IUA53_RS19325	COG2175	clavaminate synthase activity
IUA53_RS19350	COG1324	tolerance protein
IUA53_RS19355	COG4232	protein-disulfide reductase activity
IUA53_RS19360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IUA53_RS19365	COG0511	ligase activity, forming carbon-carbon bonds
IUA53_RS19370	COG0439	Biotin carboxylase
IUA53_RS19410	COG3385	transposase activity
IUA53_RS19430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IUA53_RS19435	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IUA53_RS19450	COG0151	Belongs to the GarS family
IUA53_RS19460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IUA53_RS19470	COG3954	Phosphoribulokinase
IUA53_RS19495	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IUA53_RS19500	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IUA53_RS19510	COG3031	protein transport across the cell outer membrane
IUA53_RS19520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IUA53_RS19525	COG1459	type II secretion system
IUA53_RS19530	COG2165	general secretion pathway protein
IUA53_RS19540	COG2165	general secretion pathway protein
IUA53_RS19545	COG4795	General secretion pathway protein
IUA53_RS19550	COG3156	type II secretion system protein K
IUA53_RS19560	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IUA53_RS19575	COG1012	belongs to the aldehyde dehydrogenase family
IUA53_RS19585	COG1011	Hydrolase
IUA53_RS19590	COG0494	nUDIX hydrolase
IUA53_RS19595	COG1218	3'(2'),5'-bisphosphate nucleotidase
IUA53_RS19605	COG2943	transferase activity, transferring hexosyl groups
IUA53_RS19610	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IUA53_RS19620	COG3089	Belongs to the UPF0270 family
IUA53_RS19625	COG0429	hydrolase of the alpha beta-hydrolase fold
IUA53_RS19635	COG0488	(ABC) transporter
IUA53_RS19660	COG0545	Peptidyl-prolyl cis-trans isomerase
IUA53_RS19670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IUA53_RS19675	COG2183	response to ionizing radiation
IUA53_RS19690	COG0596	Alpha beta hydrolase
IUA53_RS19695	COG1040	competence protein
IUA53_RS19710	COG1794	racemase activity, acting on amino acids and derivatives
IUA53_RS19715	COG2226	methyltransferase
IUA53_RS19725	COG0534	Mate efflux family protein
IUA53_RS19745	COG0109	protoheme IX farnesyltransferase activity
IUA53_RS19750	COG1612	heme a metabolic process
IUA53_RS19770	COG1845	cytochrome c oxidase, subunit III
IUA53_RS19780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IUA53_RS19785	COG1565	acr, cog1565
IUA53_RS19785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IUA53_RS19795	COG4774	siderophore transport
IUA53_RS19815	COG0129	dihydroxy-acid dehydratase activity
IUA53_RS19820	COG2860	membrane
IUA53_RS19825	COG0606	chelatase, subunit chli
IUA53_RS19830	COG0583	DNA-binding transcription factor activity
IUA53_RS19840	COG2814	Major facilitator Superfamily
IUA53_RS19845	COG0729	surface antigen
IUA53_RS19870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IUA53_RS19880	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IUA53_RS19900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IUA53_RS19945	COG0425	Belongs to the sulfur carrier protein TusA family
IUA53_RS19960	COG1561	YicC-like family, N-terminal region
IUA53_RS19970	COG3012	SEC-C Motif Domain Protein
IUA53_RS19995	COG3550	peptidyl-serine autophosphorylation
IUA53_RS20005	COG1484	DNA-dependent DNA replication
IUA53_RS20055	COG2211	Major facilitator Superfamily
IUA53_RS20105	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IUA53_RS20125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IUA53_RS20130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IUA53_RS20150	COG1475	DNA binding
IUA53_RS20155	COG1192	Involved in chromosome partitioning
IUA53_RS20180	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IUA53_RS20185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IUA53_RS20195	COG0706	membrane insertase activity
IUA53_RS20205	COG0594	ribonuclease P activity
IUA53_RS20210	COG0230	Belongs to the bacterial ribosomal protein bL34 family