locus-tag	class	description
AltI4_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AltI4_RS00020	COG0187	DNA topoisomerase II activity
AltI4_RS00045	COG2818	Glycosylase
AltI4_RS00055	COG3078	GTPase activator activity
AltI4_RS00075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AltI4_RS00075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AltI4_RS00080	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AltI4_RS00085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AltI4_RS00095	COG0741	lytic transglycosylase activity
AltI4_RS00120	COG0569	domain protein
AltI4_RS00125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AltI4_RS00125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AltI4_RS00130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AltI4_RS00140	COG1652	LysM domain
AltI4_RS00145	COG0758	DNA mediated transformation
AltI4_RS00160	COG0009	L-threonylcarbamoyladenylate synthase
AltI4_RS00165	COG0408	coproporphyrinogen oxidase activity
AltI4_RS00170	COG3047	cAMP biosynthetic process
AltI4_RS00185	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AltI4_RS00220	COG0587	DNA-directed DNA polymerase activity
AltI4_RS00255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AltI4_RS00280	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AltI4_RS00285	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AltI4_RS00310	COG3642	lipopolysaccharide core region biosynthetic process
AltI4_RS00315	COG0859	PFAM glycosyl transferase family 9
AltI4_RS00335	COG0156	8-amino-7-oxononanoate synthase activity
AltI4_RS00345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AltI4_RS00350	COG0705	Rhomboid family
AltI4_RS00360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AltI4_RS00365	COG2960	long-chain fatty acid transporting porin activity
AltI4_RS00370	COG0210	DNA helicase
AltI4_RS00435	COG0582	viral genome integration into host DNA
AltI4_RS00445	COG0556	nucleotide-excision repair
AltI4_RS00495	COG4771	TonB-dependent receptor
AltI4_RS00510	COG1012	belongs to the aldehyde dehydrogenase family
AltI4_RS00515	COG1024	Enoyl-CoA hydratase
AltI4_RS00570	COG2175	clavaminate synthase activity
AltI4_RS00580	COG3384	dioxygenase
AltI4_RS00595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AltI4_RS00600	COG1335	isochorismatase
AltI4_RS00635	COG4638	Rieske (2fe-2S)
AltI4_RS00645	COG2207	Transcriptional regulator
AltI4_RS00675	COG3250	beta-galactosidase activity
AltI4_RS00700	COG0494	nUDIX hydrolase
AltI4_RS00705	COG1609	Transcriptional regulator
AltI4_RS00710	COG4771	TonB-dependent receptor
AltI4_RS00715	COG3940	Belongs to the glycosyl hydrolase 43 family
AltI4_RS00755	COG0179	Fumarylacetoacetate (FAA) hydrolase
AltI4_RS00770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AltI4_RS00775	COG1228	amidohydrolase
AltI4_RS00780	COG0583	DNA-binding transcription factor activity
AltI4_RS00800	COG0642	Histidine kinase
AltI4_RS00805	COG0745	RESPONSE REGULATOR receiver
AltI4_RS00845	COG3106	COG3106 Predicted ATPase
AltI4_RS00880	COG1178	ABC-type Fe3 transport system permease component
AltI4_RS00885	COG3842	ATPase activity
AltI4_RS00905	COG2959	enzyme of heme biosynthesis
AltI4_RS00915	COG0181	hydroxymethylbilane synthase activity
AltI4_RS00920	COG0400	carboxylic ester hydrolase activity
AltI4_RS00925	COG0194	GDP metabolic process
AltI4_RS00935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AltI4_RS00945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AltI4_RS00965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AltI4_RS00975	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AltI4_RS00975	COG0678	peroxiredoxin activity
AltI4_RS00985	COG2081	HI0933 family
AltI4_RS01000	COG0667	Aldo Keto reductase
AltI4_RS01005	COG0577	efflux transmembrane transporter activity
AltI4_RS01015	COG1136	(ABC) transporter
AltI4_RS01025	COG1312	Catalyzes the dehydration of D-mannonate
AltI4_RS01030	COG2186	Transcriptional regulator
AltI4_RS01035	COG3250	beta-galactosidase activity
AltI4_RS01050	COG0583	DNA-binding transcription factor activity
AltI4_RS01055	COG0697	spore germination
AltI4_RS01070	COG0484	heat shock protein binding
AltI4_RS01080	COG0612	Peptidase, M16
AltI4_RS01085	COG0535	radical SAM domain protein
AltI4_RS01110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AltI4_RS01160	COG0583	DNA-binding transcription factor activity
AltI4_RS01165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AltI4_RS01175	COG2851	Citrate transporter
AltI4_RS01185	COG4771	TonB-dependent receptor
AltI4_RS01210	COG3300	MHYT domain
AltI4_RS01210	COG5001	Diguanylate cyclase
AltI4_RS01215	COG3829	transcription factor binding
AltI4_RS01220	COG0446	pyridine nucleotide-disulphide oxidoreductase
AltI4_RS01235	COG1294	oxidase, subunit
AltI4_RS01240	COG4890	Cyd operon protein YbgT
AltI4_RS01245	COG4988	ABC transporter
AltI4_RS01250	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AltI4_RS01290	COG0730	response to heat
AltI4_RS01300	COG1472	Belongs to the glycosyl hydrolase 3 family
AltI4_RS01310	COG2723	6-phospho-beta-galactosidase activity
AltI4_RS01315	COG2211	Major facilitator Superfamily
AltI4_RS01330	COG0840	transmembrane signaling receptor activity
AltI4_RS01340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AltI4_RS01360	COG4115	mRNA cleavage
AltI4_RS01375	COG5002	protein histidine kinase activity
AltI4_RS01390	COG0347	Belongs to the P(II) protein family
AltI4_RS01400	COG2203	Gaf domain
AltI4_RS01400	COG2199	diguanylate cyclase activity
AltI4_RS01405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AltI4_RS01410	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AltI4_RS01440	COG0089	rRNA binding
AltI4_RS01450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AltI4_RS01460	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AltI4_RS01475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AltI4_RS01480	COG1064	alcohol dehydrogenase
AltI4_RS01485	COG1519	Transferase
AltI4_RS01490	COG0025	NhaP-type Na H and K H
AltI4_RS01515	COG0121	glutamine amidotransferase
AltI4_RS01525	COG0339	signal peptide processing
AltI4_RS01530	COG0788	formyltetrahydrofolate deformylase activity
AltI4_RS01535	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AltI4_RS01540	COG1643	Atp-dependent helicase
AltI4_RS01550	COG2951	lytic endotransglycosylase activity
AltI4_RS01575	COG3243	poly(R)-hydroxyalkanoic acid synthase
AltI4_RS01585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AltI4_RS01590	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AltI4_RS01595	COG2354	Protein conserved in bacteria
AltI4_RS01610	COG0004	ammonium transporteR
AltI4_RS01615	COG0405	Gamma-glutamyltransferase
AltI4_RS01620	COG2837	iron assimilation
AltI4_RS01625	COG0583	DNA-binding transcription factor activity
AltI4_RS01630	COG0501	Belongs to the peptidase M48B family
AltI4_RS01655	COG0540	Belongs to the ATCase OTCase family
AltI4_RS01665	COG4999	Histidine kinase
AltI4_RS01665	COG3437	response regulator, receiver
AltI4_RS01665	COG3850	Histidine kinase
AltI4_RS01665	COG2205	protein histidine kinase activity
AltI4_RS01690	COG1012	belongs to the aldehyde dehydrogenase family
AltI4_RS01700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AltI4_RS01720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AltI4_RS01740	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AltI4_RS01750	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AltI4_RS01785	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AltI4_RS01790	COG0281	malic enzyme
AltI4_RS01825	COG2200	EAL domain
AltI4_RS01840	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AltI4_RS01840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AltI4_RS01850	COG0137	argininosuccinate synthase activity
AltI4_RS01870	COG1803	Methylglyoxal synthase
AltI4_RS01885	COG0745	RESPONSE REGULATOR receiver
AltI4_RS01890	COG2205	protein histidine kinase activity
AltI4_RS01895	COG2267	carboxylic ester hydrolase activity
AltI4_RS01900	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AltI4_RS01905	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AltI4_RS01915	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AltI4_RS01920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AltI4_RS01925	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AltI4_RS01930	COG4942	peptidase
AltI4_RS01935	COG2861	carbohydrate metabolic process
AltI4_RS01940	COG4206	TonB-dependent receptor
AltI4_RS01945	COG0457	Tetratricopeptide repeat
AltI4_RS01955	COG0584	glycerophosphoryl diester phosphodiesterase
AltI4_RS01970	COG1162	GTPase activity
AltI4_RS01975	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AltI4_RS01995	COG0028	Belongs to the TPP enzyme family
AltI4_RS02020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AltI4_RS02025	COG0805	protein transport
AltI4_RS02035	COG0084	hydrolase, TatD family'
AltI4_RS02050	COG0248	Ppx GppA phosphatase
AltI4_RS02055	COG0513	Belongs to the DEAD box helicase family
AltI4_RS02060	COG3118	belongs to the thioredoxin family
AltI4_RS02065	COG0826	peptidase U32
AltI4_RS02070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AltI4_RS02075	COG1473	amidohydrolase
AltI4_RS02080	COG2205	protein histidine kinase activity
AltI4_RS02080	COG0784	Response regulator, receiver
AltI4_RS02090	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AltI4_RS02095	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AltI4_RS02110	COG0783	Belongs to the Dps family
AltI4_RS02115	COG2133	pyrroloquinoline quinone binding
AltI4_RS02120	COG1506	peptidase
AltI4_RS02120	COG4946	Tricorn protease homolog
AltI4_RS02120	COG0823	Involved in the tonB-independent uptake of proteins
AltI4_RS02130	COG3118	belongs to the thioredoxin family
AltI4_RS02140	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AltI4_RS02150	COG1012	belongs to the aldehyde dehydrogenase family
AltI4_RS02175	COG2378	regulation of single-species biofilm formation
AltI4_RS02185	COG1757	Na H antiporter
AltI4_RS02190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AltI4_RS02230	COG3876	Protein conserved in bacteria
AltI4_RS02235	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AltI4_RS02240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AltI4_RS02255	COG2971	BadF BadG BcrA BcrD
AltI4_RS02265	COG4251	negative regulation of phosphorylation
AltI4_RS02265	COG5001	Diguanylate cyclase
AltI4_RS02265	COG2203	Gaf domain
AltI4_RS02265	COG3706	GGDEF domain
AltI4_RS02340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AltI4_RS02350	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AltI4_RS02390	COG2197	response regulator
AltI4_RS02400	COG0515	serine threonine protein kinase
AltI4_RS02425	COG2045	Belongs to the ComB family
AltI4_RS02435	COG0667	Aldo Keto reductase
AltI4_RS02440	COG1283	sodium-dependent phosphate transmembrane transporter activity
AltI4_RS02450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AltI4_RS02460	COG1247	-acetyltransferase
AltI4_RS02475	COG4067	protein conserved in archaea
AltI4_RS02475	COG0189	ligase activity
AltI4_RS02485	COG0189	ligase activity
AltI4_RS02490	COG2205	protein histidine kinase activity
AltI4_RS02490	COG0784	Response regulator, receiver
AltI4_RS02500	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AltI4_RS02505	COG0517	IMP dehydrogenase activity
AltI4_RS02505	COG0516	GMP reductase activity
AltI4_RS02530	COG0840	transmembrane signaling receptor activity
AltI4_RS02560	COG2234	aminopeptidase activity
AltI4_RS02570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AltI4_RS02575	COG0572	uridine kinase
AltI4_RS02595	COG1438	arginine binding
AltI4_RS02600	COG0039	L-malate dehydrogenase activity
AltI4_RS02605	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AltI4_RS02610	COG0545	Peptidyl-prolyl cis-trans isomerase
AltI4_RS02620	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AltI4_RS02625	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AltI4_RS02630	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AltI4_RS02635	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AltI4_RS02640	COG1805	sodium ion transport
AltI4_RS02645	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AltI4_RS02650	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AltI4_RS02655	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AltI4_RS02660	COG2871	sodium ion transport
AltI4_RS02665	COG1477	protein flavinylation
AltI4_RS02675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AltI4_RS02695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AltI4_RS02710	COG3123	guanosine phosphorylase activity
AltI4_RS02715	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AltI4_RS02725	COG5002	protein histidine kinase activity
AltI4_RS02725	COG5001	Diguanylate cyclase
AltI4_RS02745	COG0702	epimerase
AltI4_RS02755	COG0848	biopolymer transport protein
AltI4_RS02765	COG0716	FMN binding
AltI4_RS02780	COG0384	phenazine biosynthesis protein PhzF
AltI4_RS02785	COG1522	sequence-specific DNA binding
AltI4_RS02790	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AltI4_RS02795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AltI4_RS02810	COG0733	neurotransmitter:sodium symporter activity
AltI4_RS02815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AltI4_RS02840	COG0668	transmembrane transport
AltI4_RS02845	COG0204	Acyl-transferase
AltI4_RS02850	COG0204	Acyl-transferase
AltI4_RS02855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AltI4_RS02860	COG0667	Aldo Keto reductase
AltI4_RS02865	COG1472	Belongs to the glycosyl hydrolase 3 family
AltI4_RS02915	COG3291	Pkd domain containing protein
AltI4_RS02925	COG2115	Belongs to the xylose isomerase family
AltI4_RS02930	COG1070	Carbohydrate kinase
AltI4_RS02935	COG1609	Transcriptional regulator
AltI4_RS02935	COG2207	Transcriptional regulator
AltI4_RS02950	COG0583	DNA-binding transcription factor activity
AltI4_RS02965	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AltI4_RS02970	COG1917	Cupin 2, conserved barrel domain protein
AltI4_RS02970	COG2207	Transcriptional regulator
AltI4_RS02975	COG3250	beta-galactosidase activity
AltI4_RS02980	COG0673	inositol 2-dehydrogenase activity
AltI4_RS02985	COG0477	Major facilitator Superfamily
AltI4_RS03025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AltI4_RS03040	COG1842	Phage shock protein A
AltI4_RS03065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AltI4_RS03085	COG3300	MHYT domain
AltI4_RS03085	COG5001	Diguanylate cyclase
AltI4_RS03090	COG1573	uracil-dna glycosylase
AltI4_RS03100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AltI4_RS03105	COG2205	protein histidine kinase activity
AltI4_RS03110	COG5001	Diguanylate cyclase
AltI4_RS03120	COG1309	transcriptional regulator
AltI4_RS03180	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AltI4_RS03190	COG0183	Belongs to the thiolase family
AltI4_RS03195	COG1024	Enoyl-CoA hydratase
AltI4_RS03195	COG1250	3-hydroxyacyl-CoA dehydrogenase
AltI4_RS03205	COG0006	proline dipeptidase activity
AltI4_RS03215	COG0142	geranyltranstransferase activity
AltI4_RS03275	COG3385	transposase activity
AltI4_RS03280	COG4191	Histidine kinase
AltI4_RS03280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AltI4_RS03285	COG0784	Response regulator, receiver
AltI4_RS03285	COG3437	response regulator, receiver
AltI4_RS03290	COG4191	Histidine kinase
AltI4_RS03290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AltI4_RS03300	COG1388	LysM domain
AltI4_RS03300	COG4942	peptidase
AltI4_RS03305	COG1238	metal cluster binding
AltI4_RS03315	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AltI4_RS03320	COG0585	pseudouridine synthase activity
AltI4_RS03335	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AltI4_RS03350	COG2119	membrane
AltI4_RS03355	COG4991	sh3 domain protein
AltI4_RS03370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AltI4_RS03380	COG0494	nUDIX hydrolase
AltI4_RS03390	COG0730	response to heat
AltI4_RS03395	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AltI4_RS03400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AltI4_RS03405	COG2201	protein-glutamate methylesterase activity
AltI4_RS03410	COG3706	GGDEF domain
AltI4_RS03415	COG2223	nitrite transmembrane transporter activity
AltI4_RS03430	COG0564	pseudouridine synthase activity
AltI4_RS03435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AltI4_RS03440	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AltI4_RS03450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AltI4_RS03450	COG1648	precorrin-2 dehydrogenase activity
AltI4_RS03455	COG0513	Belongs to the DEAD box helicase family
AltI4_RS03475	COG1538	Outer membrane efflux protein
AltI4_RS03480	COG0494	nUDIX hydrolase
AltI4_RS03485	COG3151	Protein conserved in bacteria
AltI4_RS03490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AltI4_RS03495	COG3150	esterase
AltI4_RS03500	COG0187	DNA topoisomerase II activity
AltI4_RS03525	COG1509	lysine 2,3-aminomutase activity
AltI4_RS03530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AltI4_RS03535	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AltI4_RS03580	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AltI4_RS03595	COG0200	Binds to the 23S rRNA
AltI4_RS03600	COG0201	protein transport
AltI4_RS03625	COG0202	RNA polymerase activity
AltI4_RS03685	COG4584	PFAM Integrase catalytic
AltI4_RS03770	COG1216	Glycosyl transferase, family 2
AltI4_RS03775	COG0463	Glycosyl transferase, family 2
AltI4_RS03785	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AltI4_RS03805	COG2197	response regulator
AltI4_RS03810	COG2197	response regulator
AltI4_RS03830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AltI4_RS03860	COG1091	dTDP-4-dehydrorhamnose reductase activity
AltI4_RS03875	COG1088	dTDP-glucose 4,6-dehydratase activity
AltI4_RS03885	COG1216	Glycosyl transferase, family 2
AltI4_RS03885	COG0438	transferase activity, transferring glycosyl groups
AltI4_RS03920	COG0417	DNA replication proofreading
AltI4_RS03960	COG4191	Histidine kinase
AltI4_RS03960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AltI4_RS03970	COG2205	protein histidine kinase activity
AltI4_RS03970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AltI4_RS03970	COG2198	Histidine kinase
AltI4_RS03970	COG0784	Response regulator, receiver
AltI4_RS04000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AltI4_RS04005	COG0730	response to heat
AltI4_RS04015	COG0583	DNA-binding transcription factor activity
AltI4_RS04025	COG0531	amino acid
AltI4_RS04040	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AltI4_RS04085	COG0583	DNA-binding transcription factor activity
AltI4_RS04090	COG1696	Membrane protein involved in D-alanine export
AltI4_RS04100	COG2207	Transcriptional regulator
AltI4_RS04105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AltI4_RS04115	COG1538	Outer membrane efflux protein
AltI4_RS04130	COG4771	TonB-dependent receptor
AltI4_RS04135	COG0583	DNA-binding transcription factor activity
AltI4_RS04140	COG1012	belongs to the aldehyde dehydrogenase family
AltI4_RS04150	COG2010	Cytochrome c
AltI4_RS04150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AltI4_RS04160	COG1131	(ABC) transporter
AltI4_RS04170	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AltI4_RS04175	COG4585	Histidine kinase
AltI4_RS04180	COG2197	response regulator
AltI4_RS04185	COG3264	Mechanosensitive ion channel
AltI4_RS04185	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AltI4_RS04190	COG1595	DNA-templated transcription, initiation
AltI4_RS04220	COG1028	Short-chain dehydrogenase reductase Sdr
AltI4_RS04240	COG1854	S-ribosylhomocysteine lyase activity
AltI4_RS04250	COG2197	response regulator
AltI4_RS04255	COG4585	Histidine kinase
AltI4_RS04270	COG0625	glutathione transferase activity
AltI4_RS04275	COG1234	tRNA 3'-trailer cleavage
AltI4_RS04345	COG1595	DNA-templated transcription, initiation
AltI4_RS04370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AltI4_RS04380	COG0625	glutathione transferase activity
AltI4_RS04395	COG1733	regulation of RNA biosynthetic process
AltI4_RS04405	COG2249	NAD(P)H dehydrogenase (quinone) activity
AltI4_RS04465	COG0795	lipopolysaccharide-transporting ATPase activity
AltI4_RS04470	COG0795	lipopolysaccharide-transporting ATPase activity
AltI4_RS04475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AltI4_RS04480	COG2927	DNA polymerase III (CHI subunit)
AltI4_RS04485	COG0525	valine-tRNA ligase activity
AltI4_RS04490	COG2223	nitrite transmembrane transporter activity
AltI4_RS04495	COG2815	serine threonine protein kinase
AltI4_RS04495	COG0515	serine threonine protein kinase
AltI4_RS04505	COG4771	TonB-dependent receptor
AltI4_RS04510	COG1858	cytochrome C peroxidase
AltI4_RS04525	COG4206	TonB-dependent receptor
AltI4_RS04535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AltI4_RS04550	COG0514	ATP-dependent DNA helicase (RecQ)
AltI4_RS04560	COG2832	Protein of unknown function (DUF454)
AltI4_RS04565	COG1294	oxidase, subunit
AltI4_RS04570	COG1271	oxidase subunit
AltI4_RS04680	COG0501	Belongs to the peptidase M48B family
AltI4_RS04685	COG4269	membrane
AltI4_RS04695	COG0204	Acyl-transferase
AltI4_RS04700	COG3437	response regulator, receiver
AltI4_RS04705	COG2204	response regulator
AltI4_RS04710	COG3852	Histidine kinase
AltI4_RS04720	COG0174	glutamine synthetase
AltI4_RS04725	COG1217	gtp-binding protein TYPA
AltI4_RS04735	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AltI4_RS04740	COG1914	H( )-stimulated, divalent metal cation uptake system
AltI4_RS04755	COG1981	membrane
AltI4_RS04800	COG1523	belongs to the glycosyl hydrolase 13 family
AltI4_RS04805	COG2165	general secretion pathway protein
AltI4_RS04825	COG1902	pentaerythritol trinitrate reductase activity
AltI4_RS04835	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AltI4_RS04840	COG0739	heme binding
AltI4_RS04845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AltI4_RS04865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AltI4_RS04905	COG1028	Short-chain dehydrogenase reductase Sdr
AltI4_RS04920	COG4221	oxidoreductase activity
AltI4_RS04930	COG1028	Short-chain dehydrogenase reductase Sdr
AltI4_RS04965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AltI4_RS04990	COG1162	GTPase activity
AltI4_RS04995	COG0653	protein targeting
AltI4_RS05005	COG0183	Belongs to the thiolase family
AltI4_RS05010	COG1250	3-hydroxyacyl-CoA dehydrogenase
AltI4_RS05035	COG1960	acyl-CoA dehydrogenase activity
AltI4_RS05040	COG1960	acyl-CoA dehydrogenase activity
AltI4_RS05060	COG0183	Belongs to the thiolase family
AltI4_RS05070	COG4771	TonB-dependent receptor
AltI4_RS05080	COG0493	'glutamate synthase
AltI4_RS05085	COG0070	glutamate synthase
AltI4_RS05085	COG0067	glutamate synthase
AltI4_RS05085	COG0069	glutamate synthase activity
AltI4_RS05090	COG5002	protein histidine kinase activity
AltI4_RS05090	COG0784	Response regulator, receiver
AltI4_RS05090	COG2198	Histidine kinase
AltI4_RS05110	COG2828	Protein conserved in bacteria
AltI4_RS05115	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AltI4_RS05120	COG0372	Belongs to the citrate synthase family
AltI4_RS05125	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AltI4_RS05140	COG2823	Periplasmic or secreted lipoprotein
AltI4_RS05150	COG0792	nuclease activity
AltI4_RS05160	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AltI4_RS05175	COG1748	Saccharopine dehydrogenase
AltI4_RS05205	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AltI4_RS05220	COG5001	Diguanylate cyclase
AltI4_RS05220	COG3300	MHYT domain
AltI4_RS05225	COG2205	protein histidine kinase activity
AltI4_RS05225	COG0784	Response regulator, receiver
AltI4_RS05240	COG0083	homoserine kinase activity
AltI4_RS05245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AltI4_RS05250	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AltI4_RS05275	COG1506	peptidase
AltI4_RS05275	COG0823	Involved in the tonB-independent uptake of proteins
AltI4_RS05295	COG0762	integral membrane protein
AltI4_RS05300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AltI4_RS05325	COG0596	Alpha beta hydrolase
AltI4_RS05340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AltI4_RS05345	COG1678	Uncharacterized ACR, COG1678
AltI4_RS05350	COG0189	ligase activity
AltI4_RS05355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AltI4_RS05360	COG0668	transmembrane transport
AltI4_RS05380	COG0745	RESPONSE REGULATOR receiver
AltI4_RS05390	COG0835	chemotaxis
AltI4_RS05405	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AltI4_RS05415	COG4191	Histidine kinase
AltI4_RS05420	COG2204	response regulator
AltI4_RS05425	COG3706	GGDEF domain
AltI4_RS05440	COG0678	peroxiredoxin activity
AltI4_RS05440	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AltI4_RS05460	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AltI4_RS05465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AltI4_RS05495	COG1119	ATPase activity
AltI4_RS05500	COG2001	Belongs to the MraZ family
AltI4_RS05510	COG3116	cell division
AltI4_RS05515	COG0768	penicillin binding
AltI4_RS05520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AltI4_RS05525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AltI4_RS05535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AltI4_RS05540	COG0772	Belongs to the SEDS family
AltI4_RS05545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AltI4_RS05550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AltI4_RS05555	COG1181	Belongs to the D-alanine--D-alanine ligase family
AltI4_RS05560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AltI4_RS05565	COG0849	cell division
AltI4_RS05575	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AltI4_RS05580	COG0739	heme binding
AltI4_RS05580	COG0741	lytic transglycosylase activity
AltI4_RS05580	COG1196	nuclear chromosome segregation
AltI4_RS05590	COG0494	nUDIX hydrolase
AltI4_RS05595	COG0840	transmembrane signaling receptor activity
AltI4_RS05595	COG3290	protein histidine kinase activity
AltI4_RS05600	COG0835	chemotaxis
AltI4_RS05605	COG2201	protein-glutamate methylesterase activity
AltI4_RS05615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AltI4_RS05625	COG2198	Histidine kinase
AltI4_RS05625	COG0643	Histidine kinase
AltI4_RS05635	COG1192	Involved in chromosome partitioning
AltI4_RS05640	COG0745	RESPONSE REGULATOR receiver
AltI4_RS05645	COG0840	transmembrane signaling receptor activity
AltI4_RS05650	COG0840	transmembrane signaling receptor activity
AltI4_RS05655	COG2186	Transcriptional regulator
AltI4_RS05660	COG2186	Transcriptional regulator
AltI4_RS05690	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AltI4_RS05700	COG0800	Aldolase
AltI4_RS05705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AltI4_RS05710	COG2271	Major facilitator Superfamily
AltI4_RS05730	COG2084	Dehydrogenase
AltI4_RS05770	COG0583	DNA-binding transcription factor activity
AltI4_RS05780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AltI4_RS05785	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AltI4_RS05790	COG0513	Belongs to the DEAD box helicase family
AltI4_RS05795	COG0617	tRNA 3'-terminal CCA addition
AltI4_RS05800	COG3409	Peptidoglycan-binding domain 1 protein
AltI4_RS05800	COG3267	Type II secretory pathway component ExeA
AltI4_RS05815	COG0066	3-isopropylmalate dehydratase activity
AltI4_RS05825	COG0473	3-isopropylmalate dehydrogenase activity
AltI4_RS05830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AltI4_RS05850	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AltI4_RS05875	COG4133	protoheme IX ABC transporter activity
AltI4_RS05880	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AltI4_RS05885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AltI4_RS05890	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AltI4_RS05900	COG1138	Cytochrome C-type biogenesis protein
AltI4_RS05925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AltI4_RS05935	COG3104	oligopeptide transport
AltI4_RS05965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AltI4_RS05970	COG1215	transferase activity, transferring glycosyl groups
AltI4_RS05985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AltI4_RS05990	COG0483	inositol monophosphate 1-phosphatase activity
AltI4_RS06000	COG1045	serine acetyltransferase
AltI4_RS06005	COG1959	2 iron, 2 sulfur cluster binding
AltI4_RS06010	COG1104	cysteine desulfurase activity
AltI4_RS06015	COG0719	Fe-S assembly protein
AltI4_RS06020	COG0396	ATPase activity
AltI4_RS06025	COG0719	Fe-S assembly protein
AltI4_RS06030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AltI4_RS06045	COG2166	iron-sulfur cluster assembly
AltI4_RS06055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AltI4_RS06065	COG1426	Protein conserved in bacteria
AltI4_RS06080	COG2976	Protein conserved in bacteria
AltI4_RS06085	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AltI4_RS06100	COG1570	exodeoxyribonuclease VII activity
AltI4_RS06105	COG0517	IMP dehydrogenase activity
AltI4_RS06105	COG0516	GMP reductase activity
AltI4_RS06120	COG0840	transmembrane signaling receptor activity
AltI4_RS06125	COG0123	including yeast histone deacetylase and acetoin utilization protein
AltI4_RS06135	COG1234	tRNA 3'-trailer cleavage
AltI4_RS06145	COG1720	tRNA m6t6A37 methyltransferase activity
AltI4_RS06150	COG1131	(ABC) transporter
AltI4_RS06205	COG0544	peptidyl-prolyl cis-trans isomerase activity
AltI4_RS06210	COG0740	serine-type endopeptidase activity
AltI4_RS06215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AltI4_RS06220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AltI4_RS06225	COG0776	regulation of translation
AltI4_RS06230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AltI4_RS06270	COG0268	Binds directly to 16S ribosomal RNA
AltI4_RS06275	COG2239	Acts as a magnesium transporter
AltI4_RS06280	COG0728	peptidoglycan biosynthetic process
AltI4_RS06285	COG0196	riboflavin kinase activity
AltI4_RS06290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AltI4_RS06300	COG1047	Peptidyl-prolyl cis-trans
AltI4_RS06305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AltI4_RS06375	COG3209	COG3209 Rhs family protein
AltI4_RS06395	COG1484	DNA-dependent DNA replication
AltI4_RS06400	COG4584	PFAM Integrase catalytic
AltI4_RS06420	COG4969	Belongs to the N-Me-Phe pilin family
AltI4_RS06435	COG1047	Peptidyl-prolyl cis-trans
AltI4_RS06445	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AltI4_RS06455	COG2030	dehydratase
AltI4_RS06465	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AltI4_RS06470	COG1595	DNA-templated transcription, initiation
AltI4_RS06500	COG0571	ribonuclease III activity
AltI4_RS06505	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AltI4_RS06515	COG0084	hydrolase, TatD family'
AltI4_RS06525	COG0560	Phosphoserine phosphatase
AltI4_RS06550	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AltI4_RS06560	COG0488	(ABC) transporter
AltI4_RS06565	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AltI4_RS06580	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AltI4_RS06580	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AltI4_RS06595	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AltI4_RS06605	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AltI4_RS06610	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AltI4_RS06620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AltI4_RS06625	COG0142	geranyltranstransferase activity
AltI4_RS06630	COG1722	exodeoxyribonuclease VII activity
AltI4_RS06635	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AltI4_RS06645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AltI4_RS06655	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AltI4_RS06660	COG4221	oxidoreductase activity
AltI4_RS06675	COG1595	DNA-templated transcription, initiation
AltI4_RS06680	COG3806	Anti-sigma factor
AltI4_RS06705	COG0542	response to heat
AltI4_RS06720	COG1183	phosphatidylcholine synthase activity
AltI4_RS06750	COG3547	Transposase (IS116 IS110 IS902 family)
AltI4_RS06755	COG3547	Transposase (IS116 IS110 IS902 family)
AltI4_RS06770	COG0840	transmembrane signaling receptor activity
AltI4_RS06780	COG3220	belongs to the UPF0276 family
AltI4_RS06790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AltI4_RS06795	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AltI4_RS06805	COG0277	FAD linked oxidase domain protein
AltI4_RS06810	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AltI4_RS06815	COG0326	Molecular chaperone. Has ATPase activity
AltI4_RS06820	COG1609	Transcriptional regulator
AltI4_RS06835	COG3250	beta-galactosidase activity
AltI4_RS06840	COG4206	TonB-dependent receptor
AltI4_RS06880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AltI4_RS06880	COG0140	phosphoribosyl-ATP diphosphatase activity
AltI4_RS06895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AltI4_RS06900	COG0131	Imidazoleglycerol-phosphate dehydratase
AltI4_RS06900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AltI4_RS06905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AltI4_RS06910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AltI4_RS06915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AltI4_RS06935	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AltI4_RS06955	COG0783	Belongs to the Dps family
AltI4_RS06990	COG3706	GGDEF domain
AltI4_RS07000	COG3008	intermembrane lipid transfer
AltI4_RS07005	COG2995	paraquat-inducible protein a
AltI4_RS07010	COG0017	Asparaginyl-tRNA synthetase
AltI4_RS07070	COG3340	Belongs to the peptidase S51 family
AltI4_RS07075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AltI4_RS07080	COG4139	cobalamin transport
AltI4_RS07090	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AltI4_RS07100	COG3530	Putative quorum-sensing-regulated virulence factor
AltI4_RS07105	COG5265	(ABC) transporter
AltI4_RS07110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AltI4_RS07115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AltI4_RS07120	COG3706	GGDEF domain
AltI4_RS07125	COG0745	RESPONSE REGULATOR receiver
AltI4_RS07145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AltI4_RS07170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AltI4_RS07180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AltI4_RS07185	COG4948	Mandelate Racemase Muconate Lactonizing
AltI4_RS07200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AltI4_RS07205	COG0402	S-adenosylhomocysteine deaminase activity
AltI4_RS07210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AltI4_RS07230	COG4181	ATPase activity
AltI4_RS07235	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AltI4_RS07250	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AltI4_RS07275	COG0702	epimerase
AltI4_RS07280	COG1733	regulation of RNA biosynthetic process
AltI4_RS07295	COG3507	Belongs to the glycosyl hydrolase 43 family
AltI4_RS07300	COG1090	epimerase
AltI4_RS07305	COG0628	permease
AltI4_RS07320	COG2205	protein histidine kinase activity
AltI4_RS07335	COG2350	Protein conserved in bacteria
AltI4_RS07340	COG0159	tryptophan synthase activity
AltI4_RS07350	COG0135	phosphoribosylanthranilate isomerase activity
AltI4_RS07350	COG0134	indole-3-glycerol-phosphate synthase activity
AltI4_RS07355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AltI4_RS07365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AltI4_RS07370	COG0613	PHP domain protein
AltI4_RS07375	COG0009	L-threonylcarbamoyladenylate synthase
AltI4_RS07385	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AltI4_RS07415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AltI4_RS07455	COG1714	RDD family
AltI4_RS07475	COG0386	Belongs to the glutathione peroxidase family
AltI4_RS07495	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AltI4_RS07500	COG0497	DNA recombination
AltI4_RS07515	COG5001	Diguanylate cyclase
AltI4_RS07515	COG3300	MHYT domain
AltI4_RS07530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AltI4_RS07535	COG1028	Short-chain dehydrogenase reductase Sdr
AltI4_RS07545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AltI4_RS07550	COG2610	gluconate transmembrane transporter activity
AltI4_RS07585	COG5002	protein histidine kinase activity
AltI4_RS07585	COG0784	Response regulator, receiver
AltI4_RS07585	COG2205	protein histidine kinase activity
AltI4_RS07590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AltI4_RS07600	COG0484	heat shock protein binding
AltI4_RS07610	COG3300	MHYT domain
AltI4_RS07610	COG5001	Diguanylate cyclase
AltI4_RS07630	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AltI4_RS07635	COG0505	Belongs to the CarA family
AltI4_RS07640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AltI4_RS07655	COG0454	-acetyltransferase
AltI4_RS07675	COG0659	secondary active sulfate transmembrane transporter activity
AltI4_RS07710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AltI4_RS07720	COG4974	Belongs to the 'phage' integrase family
AltI4_RS07730	COG0464	growth
AltI4_RS07745	COG1484	DNA-dependent DNA replication
AltI4_RS07750	COG4584	PFAM Integrase catalytic
AltI4_RS07760	COG0071	Belongs to the small heat shock protein (HSP20) family
AltI4_RS07765	COG1228	amidohydrolase
AltI4_RS07770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AltI4_RS07775	COG4535	Mg2 and Co2 transporter CorC
AltI4_RS07785	COG1702	phosphate starvation-inducible protein PhoH
AltI4_RS07795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AltI4_RS07800	COG1115	amino acid carrier protein
AltI4_RS07830	COG0012	GTP binding
AltI4_RS07855	COG2205	protein histidine kinase activity
AltI4_RS07855	COG0784	Response regulator, receiver
AltI4_RS07870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AltI4_RS07875	COG3300	MHYT domain
AltI4_RS07875	COG5001	Diguanylate cyclase
AltI4_RS07885	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AltI4_RS07895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AltI4_RS07905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AltI4_RS07915	COG2890	protein-(glutamine-N5) methyltransferase activity
AltI4_RS07920	COG0784	Response regulator, receiver
AltI4_RS07920	COG3437	response regulator, receiver
AltI4_RS07930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AltI4_RS07940	COG0583	DNA-binding transcription factor activity
AltI4_RS07950	COG2363	Small membrane protein
AltI4_RS07965	COG4191	Histidine kinase
AltI4_RS08050	COG2204	response regulator
AltI4_RS08060	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AltI4_RS08120	COG1199	ATP-dependent helicase activity
AltI4_RS08125	COG1214	PFAM Peptidase M22, glycoprotease
AltI4_RS08150	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AltI4_RS08160	COG2951	lytic endotransglycosylase activity
AltI4_RS08165	COG0179	Fumarylacetoacetate (FAA) hydrolase
AltI4_RS08170	COG2983	Belongs to the UPF0260 family
AltI4_RS08180	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AltI4_RS08190	COG2186	Transcriptional regulator
AltI4_RS08225	COG4399	Belongs to the UPF0754 family
AltI4_RS08240	COG2226	methyltransferase
AltI4_RS08270	COG3072	Adenylate cyclase
AltI4_RS08280	COG1309	transcriptional regulator
AltI4_RS08285	COG0446	pyridine nucleotide-disulphide oxidoreductase
AltI4_RS08285	COG1902	pentaerythritol trinitrate reductase activity
AltI4_RS08305	COG3101	peptidyl-lysine hydroxylation
AltI4_RS08335	COG2026	Addiction module toxin, RelE StbE family
AltI4_RS08365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AltI4_RS08365	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AltI4_RS08375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AltI4_RS08400	COG0101	tRNA pseudouridine synthase activity
AltI4_RS08410	COG0285	dihydrofolate synthase activity
AltI4_RS08415	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AltI4_RS08420	COG1286	toxin biosynthetic process
AltI4_RS08425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AltI4_RS08460	COG1785	Belongs to the alkaline phosphatase family
AltI4_RS08465	COG1785	Belongs to the alkaline phosphatase family
AltI4_RS08470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AltI4_RS08475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AltI4_RS08480	COG0215	cysteine-tRNA ligase activity
AltI4_RS08490	COG3344	reverse transcriptase
AltI4_RS08500	COG2204	response regulator
AltI4_RS08505	COG4206	TonB-dependent receptor
AltI4_RS08515	COG0471	metal ion transport
AltI4_RS08535	COG1388	LysM domain
AltI4_RS08535	COG0741	lytic transglycosylase activity
AltI4_RS08540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AltI4_RS08545	COG2226	methyltransferase
AltI4_RS08550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AltI4_RS08550	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AltI4_RS08565	COG1082	Xylose isomerase domain protein TIM barrel
AltI4_RS08585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AltI4_RS08590	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AltI4_RS08595	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AltI4_RS08600	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AltI4_RS08610	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AltI4_RS08620	COG1451	nucleotide metabolic process
AltI4_RS08640	COG2199	diguanylate cyclase activity
AltI4_RS08645	COG0488	(ABC) transporter
AltI4_RS08660	COG0318	PFAM AMP-dependent synthetase and ligase
AltI4_RS08670	COG1620	l-lactate permease
AltI4_RS08680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AltI4_RS08690	COG2814	Major facilitator Superfamily
AltI4_RS08700	COG0798	PFAM Bile acid sodium symporter
AltI4_RS08705	COG0431	NADPH-dependent FMN reductase
AltI4_RS08715	COG0640	Transcriptional regulator
AltI4_RS08760	COG0583	DNA-binding transcription factor activity
AltI4_RS08765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AltI4_RS08775	COG2159	amidohydrolase
AltI4_RS08790	COG0667	Aldo Keto reductase
AltI4_RS08795	COG3384	dioxygenase
AltI4_RS08800	COG4771	TonB-dependent receptor
AltI4_RS08815	COG2871	sodium ion transport
AltI4_RS08825	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AltI4_RS08840	COG0277	FAD linked oxidase domain protein
AltI4_RS08850	COG2823	Periplasmic or secreted lipoprotein
AltI4_RS08860	COG2853	Lipoprotein
AltI4_RS08890	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AltI4_RS08900	COG0784	Response regulator, receiver
AltI4_RS08900	COG2198	Histidine kinase
AltI4_RS08900	COG5002	protein histidine kinase activity
AltI4_RS08905	COG0784	Response regulator, receiver
AltI4_RS08910	COG4251	negative regulation of phosphorylation
AltI4_RS08920	COG2204	response regulator
AltI4_RS08935	COG0640	Transcriptional regulator
AltI4_RS08945	COG0583	DNA-binding transcription factor activity
AltI4_RS08960	COG3300	MHYT domain
AltI4_RS08960	COG5001	Diguanylate cyclase
AltI4_RS08965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AltI4_RS08965	COG2010	Cytochrome c
AltI4_RS08975	COG1022	Amp-dependent synthetase and ligase
AltI4_RS08990	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AltI4_RS08995	COG1074	ATP-dependent DNA helicase activity
AltI4_RS09000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AltI4_RS09030	COG0521	Mo-molybdopterin cofactor biosynthetic process
AltI4_RS09035	COG0315	cyclic pyranopterin monophosphate synthase activity
AltI4_RS09040	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AltI4_RS09045	COG0314	molybdopterin synthase activity
AltI4_RS09060	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AltI4_RS09070	COG4771	TonB-dependent receptor
AltI4_RS09100	COG0668	transmembrane transport
AltI4_RS09120	COG5002	protein histidine kinase activity
AltI4_RS09120	COG2198	Histidine kinase
AltI4_RS09120	COG0784	Response regulator, receiver
AltI4_RS09125	COG3437	response regulator, receiver
AltI4_RS09135	COG0195	Participates in both transcription termination and antitermination
AltI4_RS09150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AltI4_RS09160	COG0840	transmembrane signaling receptor activity
AltI4_RS09180	COG3153	acetyltransferase
AltI4_RS09180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AltI4_RS09200	COG3634	alkyl hydroperoxide reductase activity
AltI4_RS09225	COG1032	radical SAM domain protein
AltI4_RS09245	COG4948	Mandelate Racemase Muconate Lactonizing
AltI4_RS09255	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AltI4_RS09270	COG2733	membrane
AltI4_RS09275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AltI4_RS09280	COG1136	(ABC) transporter
AltI4_RS09280	COG0577	efflux transmembrane transporter activity
AltI4_RS09290	COG4667	esterase of the alpha-beta hydrolase superfamily
AltI4_RS09305	COG0415	Belongs to the DNA photolyase family
AltI4_RS09310	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AltI4_RS09335	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AltI4_RS09360	COG1196	nuclear chromosome segregation
AltI4_RS09395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AltI4_RS09415	COG3668	Plasmid stabilization system
AltI4_RS09450	COG1484	DNA-dependent DNA replication
AltI4_RS09455	COG4584	PFAM Integrase catalytic
AltI4_RS09560	COG3608	succinylglutamate desuccinylase aspartoacylase
AltI4_RS09560	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AltI4_RS09575	COG2867	negative regulation of translational initiation
AltI4_RS09580	COG2914	Belongs to the UPF0125 (RnfH) family
AltI4_RS09590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AltI4_RS09595	COG4771	TonB-dependent receptor
AltI4_RS09600	COG0457	Tetratricopeptide repeat
AltI4_RS09610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AltI4_RS09610	COG0574	Belongs to the PEP-utilizing enzyme family
AltI4_RS09615	COG2165	general secretion pathway protein
AltI4_RS09635	COG0277	FAD linked oxidase domain protein
AltI4_RS09635	COG0247	lactate metabolic process
AltI4_RS09650	COG2850	peptidyl-arginine hydroxylation
AltI4_RS09660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AltI4_RS09665	COG2915	High frequency lysogenization protein hflD homolog
AltI4_RS09670	COG0482	sulfurtransferase activity
AltI4_RS09675	COG1187	pseudouridine synthase activity
AltI4_RS09690	COG1278	Cold shock
AltI4_RS09695	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AltI4_RS09700	COG0542	response to heat
AltI4_RS09705	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AltI4_RS09710	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AltI4_RS09715	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AltI4_RS09720	COG0492	ferredoxin-NADP+ reductase activity
AltI4_RS09725	COG3092	negative regulation of chromosome organization
AltI4_RS09730	COG3091	SprT-like family
AltI4_RS09735	COG0616	signal peptide processing
AltI4_RS09750	COG0778	Nitroreductase
AltI4_RS09755	COG0469	pyruvate kinase activity
AltI4_RS09760	COG1737	Transcriptional regulator
AltI4_RS09765	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AltI4_RS09770	COG0363	glucosamine-6-phosphate deaminase activity
AltI4_RS09775	COG0129	dihydroxy-acid dehydratase activity
AltI4_RS09780	COG0837	glucose binding
AltI4_RS09785	COG0800	Aldolase
AltI4_RS09795	COG0676	glucose-6-phosphate 1-epimerase activity
AltI4_RS09805	COG1640	4-alpha-glucanotransferase
AltI4_RS09810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AltI4_RS09820	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AltI4_RS09840	COG2866	Carboxypeptidase
AltI4_RS09845	COG1115	amino acid carrier protein
AltI4_RS09855	COG3139	Protein of unknown function (DUF1315)
AltI4_RS09875	COG0252	asparaginase activity
AltI4_RS09900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AltI4_RS09905	COG0321	lipoyl(octanoyl) transferase activity
AltI4_RS09910	COG2921	Belongs to the UPF0250 family
AltI4_RS09915	COG1686	Belongs to the peptidase S11 family
AltI4_RS09920	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AltI4_RS09925	COG0772	Belongs to the SEDS family
AltI4_RS09930	COG0768	penicillin binding
AltI4_RS09940	COG0799	negative regulation of ribosome biogenesis
AltI4_RS09945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AltI4_RS09960	COG0495	leucyl-tRNA aminoacylation
AltI4_RS09970	COG1067	ATP-dependent peptidase activity
AltI4_RS09980	COG1534	Rna-binding protein
AltI4_RS09985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AltI4_RS09990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AltI4_RS09995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AltI4_RS10000	COG0149	triose-phosphate isomerase activity
AltI4_RS10005	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AltI4_RS10035	COG1597	lipid kinase activity
AltI4_RS10050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AltI4_RS10055	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AltI4_RS10060	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AltI4_RS10075	COG1185	polyribonucleotide nucleotidyltransferase activity
AltI4_RS10120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AltI4_RS10135	COG0658	competence protein
AltI4_RS10135	COG2333	competence protein COMEC
AltI4_RS10140	COG1132	(ABC) transporter
AltI4_RS10145	COG1663	tetraacyldisaccharide 4'-kinase activity
AltI4_RS10150	COG2835	tetraacyldisaccharide 4'-kinase activity
AltI4_RS10185	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AltI4_RS10190	COG0579	oxidoreductase
AltI4_RS10195	COG0435	Glutathione S-transferase
AltI4_RS10200	COG1741	Belongs to the pirin family
AltI4_RS10230	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AltI4_RS10235	COG1053	succinate dehydrogenase
AltI4_RS10245	COG0567	Dehydrogenase, E1 component
AltI4_RS10250	COG0508	dehydrogenase complex catalyzes the overall conversion of
AltI4_RS10310	COG0004	ammonium transporteR
AltI4_RS10320	COG1874	Beta-galactosidase
AltI4_RS10320	COG0366	Alpha amylase catalytic
AltI4_RS10325	COG1609	Transcriptional regulator
AltI4_RS10335	COG1028	Short-chain dehydrogenase reductase Sdr
AltI4_RS10340	COG2267	carboxylic ester hydrolase activity
AltI4_RS10345	COG0616	signal peptide processing
AltI4_RS10355	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AltI4_RS10360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AltI4_RS10365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AltI4_RS10370	COG2084	Dehydrogenase
AltI4_RS10385	COG1960	acyl-CoA dehydrogenase activity
AltI4_RS10390	COG1024	Enoyl-CoA hydratase
AltI4_RS10400	COG3083	sulfuric ester hydrolase activity
AltI4_RS10405	COG3082	Protein of unknown function (DUF1414)
AltI4_RS10440	COG3275	phosphorelay sensor kinase activity
AltI4_RS10445	COG3279	Response regulator of the LytR AlgR family
AltI4_RS10450	COG3693	PFAM glycoside hydrolase, family 10
AltI4_RS10455	COG0205	6-phosphofructokinase activity
AltI4_RS10475	COG0745	RESPONSE REGULATOR receiver
AltI4_RS10485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AltI4_RS10495	COG1054	Belongs to the UPF0176 family
AltI4_RS10510	COG0513	Belongs to the DEAD box helicase family
AltI4_RS10520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AltI4_RS10525	COG0583	DNA-binding transcription factor activity
AltI4_RS10530	COG2194	sulfuric ester hydrolase activity
AltI4_RS10550	COG0583	DNA-binding transcription factor activity
AltI4_RS10595	COG1484	DNA-dependent DNA replication
AltI4_RS10600	COG4584	PFAM Integrase catalytic
AltI4_RS10705	COG3250	beta-galactosidase activity
AltI4_RS10795	COG0519	Catalyzes the synthesis of GMP from XMP
AltI4_RS10830	COG1760	l-serine dehydratase
AltI4_RS10840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AltI4_RS10850	COG1322	Protein conserved in bacteria
AltI4_RS10855	COG3706	GGDEF domain
AltI4_RS10870	COG1404	Belongs to the peptidase S8 family
AltI4_RS10880	COG0022	dehydrogenase e1 component
AltI4_RS10890	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AltI4_RS10895	COG0515	serine threonine protein kinase
AltI4_RS10900	COG1946	Acyl-CoA thioesterase
AltI4_RS10905	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AltI4_RS10910	COG2715	membrane protein required for spore maturation
AltI4_RS10920	COG1956	GAF domain-containing protein
AltI4_RS10935	COG0793	Belongs to the peptidase S41A family
AltI4_RS10940	COG0733	neurotransmitter:sodium symporter activity
AltI4_RS10945	COG1757	Na H antiporter
AltI4_RS10950	COG0308	aminopeptidase N
AltI4_RS10980	COG2902	Dehydrogenase
AltI4_RS10985	COG0167	dihydroorotate dehydrogenase activity
AltI4_RS11000	COG0488	(ABC) transporter
AltI4_RS11010	COG3130	regulation of translation
AltI4_RS11015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AltI4_RS11025	COG0415	Belongs to the DNA photolyase family
AltI4_RS11030	COG0415	Belongs to the DNA photolyase family
AltI4_RS11035	COG3046	protein related to deoxyribodipyrimidine photolyase
AltI4_RS11055	COG2308	Evidence 4 Homologs of previously reported genes of
AltI4_RS11065	COG1309	transcriptional regulator
AltI4_RS11070	COG0604	alcohol dehydrogenase
AltI4_RS11085	COG4771	TonB-dependent receptor
AltI4_RS11090	COG1472	Belongs to the glycosyl hydrolase 3 family
AltI4_RS11100	COG2972	Histidine kinase
AltI4_RS11140	COG0681	Belongs to the peptidase S26 family
AltI4_RS11145	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
AltI4_RS11150	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AltI4_RS11155	COG2814	Major facilitator Superfamily
AltI4_RS11160	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AltI4_RS11165	COG0668	transmembrane transport
AltI4_RS11175	COG1028	Short-chain dehydrogenase reductase Sdr
AltI4_RS11185	COG0318	PFAM AMP-dependent synthetase and ligase
AltI4_RS11195	COG0589	response to stress
AltI4_RS11200	COG0069	glutamate synthase activity
AltI4_RS11205	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AltI4_RS11215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AltI4_RS11215	COG4651	solute:proton antiporter activity
AltI4_RS11225	COG2193	ferroxidase activity
AltI4_RS11235	COG3278	Belongs to the heme-copper respiratory oxidase family
AltI4_RS11250	COG2010	Cytochrome c
AltI4_RS11260	COG2217	Heavy metal translocating P-type atpase
AltI4_RS11275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AltI4_RS11280	COG0589	response to stress
AltI4_RS11285	COG0037	tRNA processing
AltI4_RS11290	COG1752	Esterase of the alpha-beta hydrolase superfamily
AltI4_RS11310	COG1280	lysine exporter protein (LysE YggA)
AltI4_RS11320	COG2897	thiosulfate sulfurtransferase activity
AltI4_RS11325	COG2207	Transcriptional regulator
AltI4_RS11330	COG0840	transmembrane signaling receptor activity
AltI4_RS11360	COG4584	PFAM Integrase catalytic
AltI4_RS11365	COG1484	DNA-dependent DNA replication
AltI4_RS11420	COG0322	excinuclease ABC activity
AltI4_RS11425	COG2197	response regulator
AltI4_RS11440	COG0670	Belongs to the BI1 family
AltI4_RS11445	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AltI4_RS11450	COG2923	Belongs to the DsrF TusC family
AltI4_RS11460	COG2920	part of a sulfur-relay system
AltI4_RS11475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AltI4_RS11485	COG0531	amino acid
AltI4_RS11485	COG1674	ftsk spoiiie
AltI4_RS11495	COG0686	Belongs to the AlaDH PNT family
AltI4_RS11505	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AltI4_RS11515	COG0776	regulation of translation
AltI4_RS11520	COG0539	negative regulation of cytoplasmic translation
AltI4_RS11525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AltI4_RS11530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AltI4_RS11535	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AltI4_RS11545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AltI4_RS11550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AltI4_RS11560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AltI4_RS11575	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AltI4_RS11580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AltI4_RS11590	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AltI4_RS11615	COG4783	chaperone-mediated protein folding
AltI4_RS11620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AltI4_RS11625	COG1393	Belongs to the ArsC family
AltI4_RS11645	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AltI4_RS11660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AltI4_RS11670	COG1960	acyl-CoA dehydrogenase activity
AltI4_RS11675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AltI4_RS11700	COG3769	mannosylglycerate metabolic process
AltI4_RS11705	COG1215	transferase activity, transferring glycosyl groups
AltI4_RS11715	COG0303	'Molybdopterin
AltI4_RS11720	COG0534	Mate efflux family protein
AltI4_RS11735	COG2095	MarC family integral membrane protein
AltI4_RS11745	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AltI4_RS11765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AltI4_RS11810	COG3011	Protein conserved in bacteria
AltI4_RS11825	COG0405	Gamma-glutamyltransferase
AltI4_RS11830	COG1024	Enoyl-CoA hydratase
AltI4_RS11855	COG2873	o-acetylhomoserine
AltI4_RS11870	COG1448	Aminotransferase
AltI4_RS11925	COG0596	Alpha beta hydrolase
AltI4_RS11940	COG0840	transmembrane signaling receptor activity
AltI4_RS11945	COG0735	belongs to the Fur family
AltI4_RS11950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AltI4_RS11955	COG1984	allophanate hydrolase subunit 2
AltI4_RS11960	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AltI4_RS11965	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AltI4_RS11970	COG2996	Protein conserved in bacteria
AltI4_RS11975	COG1765	OsmC-like protein
AltI4_RS11980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AltI4_RS12010	COG0436	Aminotransferase
AltI4_RS12015	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AltI4_RS12020	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AltI4_RS12110	COG2610	gluconate transmembrane transporter activity
AltI4_RS12115	COG3265	gluconokinase activity
AltI4_RS12120	COG1609	Transcriptional regulator
AltI4_RS12135	COG0084	hydrolase, TatD family'
AltI4_RS12150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AltI4_RS12155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AltI4_RS12160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AltI4_RS12165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AltI4_RS12175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AltI4_RS12180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AltI4_RS12185	COG0416	fatty acid biosynthetic process
AltI4_RS12195	COG1399	metal-binding, possibly nucleic acid-binding protein
AltI4_RS12200	COG0424	maF-like protein
AltI4_RS12210	COG0564	pseudouridine synthase activity
AltI4_RS12215	COG1530	ribonuclease E activity
AltI4_RS12245	COG3384	dioxygenase
AltI4_RS12250	COG0435	Glutathione S-transferase
AltI4_RS12255	COG2259	Doxx family
AltI4_RS12260	COG0583	DNA-binding transcription factor activity
AltI4_RS12270	COG1757	Na H antiporter
AltI4_RS12290	COG3122	Protein conserved in bacteria
AltI4_RS12295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AltI4_RS12300	COG3724	N-succinylarginine dihydrolase activity
AltI4_RS12310	COG1301	dicarboxylic acid transport
AltI4_RS12315	COG4591	ABC-type transport system involved in lipoprotein release permease component
AltI4_RS12320	COG1136	(ABC) transporter
AltI4_RS12335	COG1304	FMN binding
AltI4_RS12340	COG4952	isomerase
AltI4_RS12345	COG3347	Dehydrogenase
AltI4_RS12345	COG1028	Short-chain dehydrogenase reductase Sdr
AltI4_RS12390	COG0328	RNA-DNA hybrid ribonuclease activity
AltI4_RS12400	COG3321	synthase
AltI4_RS12400	COG0604	alcohol dehydrogenase
AltI4_RS12425	COG1643	Atp-dependent helicase
AltI4_RS12450	COG2925	Exonuclease
AltI4_RS12465	COG0183	Belongs to the thiolase family
AltI4_RS12470	COG0789	Transcriptional regulator
AltI4_RS12475	COG1960	acyl-CoA dehydrogenase activity
AltI4_RS12480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AltI4_RS12485	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AltI4_RS12490	COG4770	biotin carboxylase activity
AltI4_RS12550	COG1639	'signal transduction protein
AltI4_RS12555	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AltI4_RS12575	COG0708	Exodeoxyribonuclease III
AltI4_RS12590	COG2205	protein histidine kinase activity
AltI4_RS12595	COG0745	RESPONSE REGULATOR receiver
AltI4_RS12615	COG1671	Belongs to the UPF0178 family
AltI4_RS12625	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AltI4_RS12635	COG0456	acetyltransferase
AltI4_RS12685	COG2267	carboxylic ester hydrolase activity
AltI4_RS12710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AltI4_RS12825	COG4584	PFAM Integrase catalytic
AltI4_RS12830	COG1484	DNA-dependent DNA replication
AltI4_RS12925	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AltI4_RS12930	COG4591	ABC-type transport system involved in lipoprotein release permease component
AltI4_RS12940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AltI4_RS12950	COG2096	Adenosyltransferase
AltI4_RS12960	COG0471	metal ion transport
AltI4_RS12970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AltI4_RS12990	COG0072	phenylalanine-tRNA ligase activity
AltI4_RS12990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AltI4_RS13005	COG4774	siderophore transport
AltI4_RS13045	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AltI4_RS13055	COG3001	Fructosamine kinase
AltI4_RS13070	COG0745	RESPONSE REGULATOR receiver
AltI4_RS13105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AltI4_RS13120	COG1477	protein flavinylation
AltI4_RS13125	COG0583	DNA-binding transcription factor activity
AltI4_RS13130	COG0288	reversible hydration of carbon dioxide
AltI4_RS13135	COG0659	secondary active sulfate transmembrane transporter activity
AltI4_RS13155	COG0730	response to heat
AltI4_RS13160	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AltI4_RS13175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AltI4_RS13180	COG2233	PERMEase
AltI4_RS13195	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AltI4_RS13200	COG2252	PERMEase
AltI4_RS13210	COG1309	transcriptional regulator
AltI4_RS13220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AltI4_RS13235	COG2351	hydroxyisourate hydrolase activity
AltI4_RS13240	COG0402	S-adenosylhomocysteine deaminase activity
AltI4_RS13250	COG3447	MASE1 domain protein
AltI4_RS13250	COG5001	Diguanylate cyclase
AltI4_RS13250	COG5002	protein histidine kinase activity
AltI4_RS13255	COG4191	Histidine kinase
AltI4_RS13255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AltI4_RS13270	COG0746	molybdenum cofactor guanylyltransferase activity
AltI4_RS13280	COG1116	anion transmembrane transporter activity
AltI4_RS13290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AltI4_RS13295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AltI4_RS13300	COG1648	precorrin-2 dehydrogenase activity
AltI4_RS13300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AltI4_RS13305	COG0243	molybdopterin cofactor binding
AltI4_RS13310	COG2146	nitrite reductase [NAD(P)H] activity
AltI4_RS13315	COG2146	nitrite reductase [NAD(P)H] activity
AltI4_RS13315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AltI4_RS13330	COG3707	response regulator
AltI4_RS13390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AltI4_RS13405	COG0778	Nitroreductase
AltI4_RS13425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AltI4_RS13435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AltI4_RS13485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AltI4_RS13565	COG1845	cytochrome c oxidase, subunit III
AltI4_RS13570	COG1012	belongs to the aldehyde dehydrogenase family
AltI4_RS13625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AltI4_RS13635	COG2301	Belongs to the HpcH HpaI aldolase family
AltI4_RS13640	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
AltI4_RS13645	COG1250	3-hydroxyacyl-CoA dehydrogenase
AltI4_RS13650	COG1024	Enoyl-CoA hydratase
AltI4_RS13655	COG1024	Enoyl-CoA hydratase
AltI4_RS13660	COG0183	Belongs to the thiolase family
AltI4_RS13690	COG4584	PFAM Integrase catalytic
AltI4_RS13695	COG1484	DNA-dependent DNA replication
AltI4_RS13700	COG0633	Ferredoxin
AltI4_RS13710	COG4771	TonB-dependent receptor
AltI4_RS13750	COG2190	(PTS) system
AltI4_RS13755	COG1393	Belongs to the ArsC family
AltI4_RS13775	COG0393	Putative heavy-metal-binding
AltI4_RS13785	COG2988	succinylglutamate desuccinylase activity
AltI4_RS13795	COG3385	transposase activity
AltI4_RS13800	COG0058	SHG alpha-glucan phosphorylase activity
AltI4_RS13805	COG0033	Phosphoglucomutase
AltI4_RS13810	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AltI4_RS13815	COG0714	Associated with various cellular activities
AltI4_RS13830	COG2205	protein histidine kinase activity
AltI4_RS13845	COG0577	efflux transmembrane transporter activity
AltI4_RS13845	COG1136	(ABC) transporter
AltI4_RS13855	COG0793	Belongs to the peptidase S41A family
AltI4_RS13855	COG4946	Tricorn protease homolog
AltI4_RS13905	COG2274	protein secretion by the type I secretion system
AltI4_RS13910	COG0583	DNA-binding transcription factor activity
AltI4_RS13945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AltI4_RS13955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AltI4_RS13960	COG0438	transferase activity, transferring glycosyl groups
AltI4_RS13975	COG0438	transferase activity, transferring glycosyl groups
AltI4_RS13980	COG1215	transferase activity, transferring glycosyl groups
AltI4_RS13995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AltI4_RS14000	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AltI4_RS14005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AltI4_RS14020	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AltI4_RS14035	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AltI4_RS14040	COG2885	chlorophyll binding
AltI4_RS14045	COG0823	Involved in the tonB-independent uptake of proteins
AltI4_RS14060	COG0811	peptide transport
AltI4_RS14065	COG0824	Thioesterase
AltI4_RS14070	COG2130	NADP-dependent
AltI4_RS14075	COG2255	four-way junction helicase activity
AltI4_RS14080	COG0632	four-way junction helicase activity
AltI4_RS14085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AltI4_RS14090	COG0494	nUDIX hydrolase
AltI4_RS14095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AltI4_RS14110	COG2204	response regulator
AltI4_RS14120	COG2205	protein histidine kinase activity
AltI4_RS14160	COG0023	Translation Initiation Factor
AltI4_RS14165	COG0745	RESPONSE REGULATOR receiver
AltI4_RS14170	COG1605	Chorismate mutase
AltI4_RS14170	COG0077	Prephenate dehydratase
AltI4_RS14175	COG0287	Prephenate dehydrogenase
AltI4_RS14175	COG1605	Chorismate mutase
AltI4_RS14180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AltI4_RS14185	COG1136	(ABC) transporter
AltI4_RS14205	COG0577	efflux transmembrane transporter activity
AltI4_RS14205	COG1136	(ABC) transporter
AltI4_RS14230	COG0335	large ribosomal subunit rRNA binding
AltI4_RS14235	COG0336	Belongs to the RNA methyltransferase TrmD family
AltI4_RS14240	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AltI4_RS14245	COG0228	four-way junction DNA binding
AltI4_RS14250	COG1132	(ABC) transporter
AltI4_RS14260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AltI4_RS14300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AltI4_RS14305	COG4137	Cytochrome C assembly protein
AltI4_RS14310	COG4536	flavin adenine dinucleotide binding
AltI4_RS14335	COG1250	3-hydroxyacyl-CoA dehydrogenase
AltI4_RS14335	COG1024	Enoyl-CoA hydratase
AltI4_RS14345	COG0714	Associated with various cellular activities
AltI4_RS14380	COG1595	DNA-templated transcription, initiation
AltI4_RS14390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AltI4_RS14395	COG0175	sulfate reduction
AltI4_RS14400	COG0529	Catalyzes the synthesis of activated sulfate
AltI4_RS14415	COG0471	metal ion transport
AltI4_RS14415	COG3273	potassium ion transport
AltI4_RS14440	COG1501	Belongs to the glycosyl hydrolase 31 family
AltI4_RS14445	COG1874	Beta-galactosidase
AltI4_RS14475	COG3344	reverse transcriptase
AltI4_RS14485	COG1668	transmembrane transport
AltI4_RS14490	COG4555	ABC transporter
AltI4_RS14510	COG0367	asparagine synthase
AltI4_RS14520	COG0602	queuosine metabolic process
AltI4_RS14540	COG4628	conserved protein (DUF2132)
AltI4_RS14545	COG0556	nucleotide-excision repair
AltI4_RS14550	COG0534	Mate efflux family protein
AltI4_RS14565	COG4657	Part of a membrane complex involved in electron transport
AltI4_RS14570	COG2878	Part of a membrane complex involved in electron transport
AltI4_RS14575	COG4656	Part of a membrane complex involved in electron transport
AltI4_RS14580	COG4658	electron transport chain
AltI4_RS14585	COG4659	FMN binding
AltI4_RS14590	COG4660	Part of a membrane complex involved in electron transport
AltI4_RS14595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AltI4_RS14600	COG2862	Uncharacterized protein family, UPF0114
AltI4_RS14620	COG0346	lactoylglutathione lyase activity
AltI4_RS14625	COG0584	glycerophosphoryl diester phosphodiesterase
AltI4_RS14640	COG0477	Major facilitator Superfamily
AltI4_RS14640	COG2814	Major facilitator Superfamily
AltI4_RS14645	COG0450	alkyl hydroperoxide reductase
AltI4_RS14670	COG4771	TonB-dependent receptor
AltI4_RS14675	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AltI4_RS14680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AltI4_RS14685	COG2766	serine protein kinase
AltI4_RS14690	COG2718	Belongs to the UPF0229 family
AltI4_RS14695	COG2719	SpoVR family
AltI4_RS14700	COG2814	Major facilitator Superfamily
AltI4_RS14710	COG2890	protein-(glutamine-N5) methyltransferase activity
AltI4_RS14715	COG2840	Smr protein MutS2
AltI4_RS14735	COG2918	glutathione biosynthetic process
AltI4_RS14740	COG0612	Peptidase, M16
AltI4_RS14750	COG0564	pseudouridine synthase activity
AltI4_RS14755	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AltI4_RS14760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AltI4_RS14830	COG4774	siderophore transport
AltI4_RS14840	COG1607	acyl-coa hydrolase
AltI4_RS14860	COG0848	biopolymer transport protein
AltI4_RS14865	COG0811	peptide transport
AltI4_RS14870	COG0811	peptide transport
AltI4_RS14905	COG1522	sequence-specific DNA binding
AltI4_RS14910	COG0625	glutathione transferase activity
AltI4_RS14920	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AltI4_RS14950	COG1842	Phage shock protein A
AltI4_RS14955	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AltI4_RS14960	COG0747	negative chemotaxis
AltI4_RS14965	COG4168	peptide transport system, permease
AltI4_RS14970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AltI4_RS14975	COG4172	Belongs to the ABC transporter superfamily
AltI4_RS14980	COG4608	Belongs to the ABC transporter superfamily
AltI4_RS14985	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AltI4_RS15000	COG1476	TRANSCRIPTIONal
AltI4_RS15030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AltI4_RS15035	COG2137	regulation of response to DNA damage stimulus
AltI4_RS15045	COG3590	peptidase
AltI4_RS15055	COG1410	methionine synthase
AltI4_RS15055	COG0646	methionine synthase
AltI4_RS15060	COG1410	methionine synthase
AltI4_RS15060	COG0646	methionine synthase
AltI4_RS15080	COG0835	chemotaxis
AltI4_RS15090	COG1192	Involved in chromosome partitioning
AltI4_RS15095	COG2201	protein-glutamate methylesterase activity
AltI4_RS15100	COG2198	Histidine kinase
AltI4_RS15100	COG0643	Histidine kinase
AltI4_RS15100	COG0784	Response regulator, receiver
AltI4_RS15105	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AltI4_RS15130	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AltI4_RS15145	COG1987	bacterial-type flagellum assembly
AltI4_RS15155	COG3190	flagellar
AltI4_RS15195	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AltI4_RS15200	COG1766	The M ring may be actively involved in energy transduction
AltI4_RS15205	COG1677	Flagellar hook-basal body complex protein FliE
AltI4_RS15260	COG1660	Displays ATPase and GTPase activities
AltI4_RS15265	COG1216	Glycosyl transferase, family 2
AltI4_RS15275	COG1216	Glycosyl transferase, family 2
AltI4_RS15290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AltI4_RS15295	COG1028	Short-chain dehydrogenase reductase Sdr
AltI4_RS15315	COG2089	acid synthase
AltI4_RS15320	COG1083	cytidylyl-transferase
AltI4_RS15325	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AltI4_RS15330	COG1086	Polysaccharide biosynthesis protein
AltI4_RS15370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AltI4_RS15390	COG1256	bacterial-type flagellum assembly
AltI4_RS15395	COG1705	Flagellar rod assembly protein muramidase FlgJ
AltI4_RS15395	COG3951	Flagellar rod assembly protein muramidase FlgJ
AltI4_RS15415	COG4787	bacterial-type flagellum-dependent cell motility
AltI4_RS15425	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AltI4_RS15435	COG1815	bacterial-type flagellum-dependent cell motility
AltI4_RS15440	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AltI4_RS15445	COG0784	Response regulator, receiver
AltI4_RS15445	COG0835	chemotaxis
AltI4_RS15495	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AltI4_RS15495	COG0047	phosphoribosylformylglycinamidine synthase activity
AltI4_RS15525	COG0037	tRNA processing
AltI4_RS15530	COG0825	malonyl-CoA metabolic process
AltI4_RS15550	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AltI4_RS15555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AltI4_RS15570	COG0750	zinc metalloprotease
AltI4_RS15575	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AltI4_RS15580	COG0575	Belongs to the CDS family
AltI4_RS15585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AltI4_RS15595	COG0528	UMP kinase activity
AltI4_RS15605	COG0052	Belongs to the universal ribosomal protein uS2 family
AltI4_RS15610	COG0024	Methionine aminopeptidase
AltI4_RS15615	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AltI4_RS15635	COG3098	single-species biofilm formation
AltI4_RS15660	COG4584	PFAM Integrase catalytic
AltI4_RS15665	COG1484	DNA-dependent DNA replication
AltI4_RS15745	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AltI4_RS15745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AltI4_RS15755	COG1611	Belongs to the LOG family
AltI4_RS15770	COG0473	3-isopropylmalate dehydrogenase activity
AltI4_RS15775	COG1555	photosystem II stabilization
AltI4_RS15775	COG1596	polysaccharide export
AltI4_RS15780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AltI4_RS15785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AltI4_RS15790	COG1862	Preprotein translocase
AltI4_RS15795	COG0343	queuine tRNA-ribosyltransferase activity
AltI4_RS15815	COG1842	Phage shock protein A
AltI4_RS15840	COG0754	glutathionylspermidine amidase activity
AltI4_RS15855	COG1785	Belongs to the alkaline phosphatase family
AltI4_RS15860	COG0835	chemotaxis
AltI4_RS15860	COG0784	Response regulator, receiver
AltI4_RS15955	COG0367	asparagine synthase
AltI4_RS15960	COG0438	transferase activity, transferring glycosyl groups
AltI4_RS15965	COG1796	DNA polymerase
AltI4_RS15965	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AltI4_RS15975	COG2244	polysaccharide biosynthetic process
AltI4_RS16000	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AltI4_RS16000	COG2755	lipolytic protein G-D-S-L family
AltI4_RS16005	COG1216	Glycosyl transferase, family 2
AltI4_RS16010	COG2755	lipolytic protein G-D-S-L family
AltI4_RS16010	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AltI4_RS16030	COG1215	transferase activity, transferring glycosyl groups
AltI4_RS16045	COG0438	transferase activity, transferring glycosyl groups
AltI4_RS16050	COG0438	transferase activity, transferring glycosyl groups
AltI4_RS16090	COG0489	protein tyrosine kinase activity
AltI4_RS16100	COG3267	Type II secretory pathway component ExeA
AltI4_RS16100	COG3409	Peptidoglycan-binding domain 1 protein
AltI4_RS16105	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AltI4_RS16105	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AltI4_RS16110	COG2827	Endonuclease containing a URI domain
AltI4_RS16130	COG1560	Kdo2-lipid A biosynthetic process
AltI4_RS16150	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AltI4_RS16155	COG1960	acyl-CoA dehydrogenase activity
AltI4_RS16160	COG5001	Diguanylate cyclase
AltI4_RS16160	COG3300	MHYT domain
AltI4_RS16165	COG1435	thymidine kinase activity
AltI4_RS16195	COG1609	Transcriptional regulator
AltI4_RS16200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AltI4_RS16215	COG3300	MHYT domain
AltI4_RS16215	COG5001	Diguanylate cyclase
AltI4_RS16220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AltI4_RS16235	COG0308	aminopeptidase N
AltI4_RS16245	COG0657	acetylesterase activity
AltI4_RS16245	COG2755	lipolytic protein G-D-S-L family
AltI4_RS16265	COG1607	acyl-coa hydrolase
AltI4_RS16295	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AltI4_RS16295	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AltI4_RS16310	COG0583	DNA-binding transcription factor activity
AltI4_RS16325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AltI4_RS16330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AltI4_RS16335	COG0006	proline dipeptidase activity
AltI4_RS16340	COG3079	Belongs to the UPF0149 family
AltI4_RS16350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AltI4_RS16360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AltI4_RS16365	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AltI4_RS16370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AltI4_RS16390	COG3313	Fe-S protein
AltI4_RS16405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AltI4_RS16410	COG0508	dehydrogenase complex catalyzes the overall conversion of
AltI4_RS16435	COG3577	Aspartyl protease
AltI4_RS16445	COG4969	Belongs to the N-Me-Phe pilin family
AltI4_RS16450	COG1459	type II secretion system
AltI4_RS16455	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AltI4_RS16485	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AltI4_RS16490	COG3608	succinylglutamate desuccinylase aspartoacylase
AltI4_RS16515	COG1346	cytolysis
AltI4_RS16575	COG2986	histidine ammonia-lyase
AltI4_RS16580	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AltI4_RS16610	COG0583	DNA-binding transcription factor activity
AltI4_RS16650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AltI4_RS16655	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AltI4_RS16665	COG3220	belongs to the UPF0276 family
AltI4_RS16675	COG3118	belongs to the thioredoxin family
AltI4_RS16725	COG1028	Short-chain dehydrogenase reductase Sdr
AltI4_RS16735	COG0583	DNA-binding transcription factor activity
AltI4_RS16750	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AltI4_RS16780	COG0308	aminopeptidase N
AltI4_RS16785	COG0251	oxidation-reduction process
AltI4_RS16790	COG1739	Uncharacterized protein family UPF0029
AltI4_RS16800	COG1272	protein, Hemolysin III
AltI4_RS16805	COG3547	Transposase (IS116 IS110 IS902 family)
AltI4_RS16810	COG1764	response to oxidative stress
AltI4_RS16815	COG1846	Transcriptional regulator
AltI4_RS16865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AltI4_RS16870	COG0513	Belongs to the DEAD box helicase family
AltI4_RS16875	COG1278	Cold shock
AltI4_RS16895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AltI4_RS16910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AltI4_RS16915	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AltI4_RS16965	COG1216	Glycosyl transferase, family 2
AltI4_RS16985	COG2199	diguanylate cyclase activity
AltI4_RS16985	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AltI4_RS17030	COG3547	Transposase (IS116 IS110 IS902 family)
AltI4_RS17050	COG1132	(ABC) transporter
AltI4_RS17060	COG1595	DNA-templated transcription, initiation
AltI4_RS17075	COG3547	Transposase (IS116 IS110 IS902 family)
AltI4_RS17085	COG0306	phosphate transporter
AltI4_RS17095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AltI4_RS17105	COG0573	inorganic phosphate transmembrane transporter activity
AltI4_RS17115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AltI4_RS17120	COG0248	Ppx GppA phosphatase
AltI4_RS17130	COG3588	fructose-bisphosphate aldolase
AltI4_RS17135	COG0126	phosphoglycerate kinase activity
AltI4_RS17145	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AltI4_RS17155	COG2954	triphosphatase activity
AltI4_RS17165	COG1794	racemase activity, acting on amino acids and derivatives
AltI4_RS17180	COG2205	protein histidine kinase activity
AltI4_RS17180	COG0784	Response regulator, receiver
AltI4_RS17245	COG1741	Belongs to the pirin family
AltI4_RS17250	COG0583	DNA-binding transcription factor activity
AltI4_RS17260	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AltI4_RS17270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AltI4_RS17285	COG5007	Belongs to the BolA IbaG family
AltI4_RS17295	COG2854	intermembrane phospholipid transfer
AltI4_RS17300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AltI4_RS17305	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AltI4_RS17310	COG1127	ABC transporter
AltI4_RS17320	COG0517	IMP dehydrogenase activity
AltI4_RS17320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AltI4_RS17325	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AltI4_RS17340	COG1137	ATPase activity
AltI4_RS17345	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AltI4_RS17365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AltI4_RS17370	COG5001	Diguanylate cyclase
AltI4_RS17370	COG3300	MHYT domain
AltI4_RS17375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AltI4_RS17380	COG4682	membrane
AltI4_RS17405	COG2239	Acts as a magnesium transporter
AltI4_RS17410	COG0745	RESPONSE REGULATOR receiver
AltI4_RS17425	COG2969	positive regulation of protein catabolic process
AltI4_RS17430	COG0625	glutathione transferase activity
AltI4_RS17435	COG2857	Cytochrome c1
AltI4_RS17440	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AltI4_RS17445	COG0723	plastoquinol--plastocyanin reductase activity
AltI4_RS17455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AltI4_RS17470	COG3956	TIGRFAM MazG family protein
AltI4_RS17475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AltI4_RS17480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AltI4_RS17490	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AltI4_RS17505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AltI4_RS17510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AltI4_RS17515	COG4974	Belongs to the 'phage' integrase family
AltI4_RS17520	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AltI4_RS17525	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AltI4_RS17530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AltI4_RS17535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AltI4_RS17545	COG2967	ApaG domain
AltI4_RS17590	COG3706	GGDEF domain
AltI4_RS17600	COG3706	GGDEF domain
AltI4_RS17600	COG2203	Gaf domain
AltI4_RS17600	COG5001	Diguanylate cyclase
AltI4_RS17600	COG4251	negative regulation of phosphorylation
AltI4_RS17605	COG0527	aspartate kinase activity
AltI4_RS17620	COG2133	pyrroloquinoline quinone binding
AltI4_RS17635	COG4771	TonB-dependent receptor
AltI4_RS17650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AltI4_RS17655	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AltI4_RS17690	COG0848	biopolymer transport protein
AltI4_RS17695	COG0811	peptide transport
AltI4_RS17700	COG0811	peptide transport
AltI4_RS17730	COG5002	protein histidine kinase activity
AltI4_RS17735	COG0745	RESPONSE REGULATOR receiver
AltI4_RS17740	COG4191	Histidine kinase
AltI4_RS17740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AltI4_RS17745	COG2974	May be involved in recombination
AltI4_RS17750	COG2311	Membrane
AltI4_RS17755	COG1396	sequence-specific DNA binding
AltI4_RS17760	COG3135	benzoate transporter
AltI4_RS17775	COG0537	adenosine 5'-monophosphoramidase activity
AltI4_RS17795	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AltI4_RS17805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AltI4_RS17835	COG0358	DNA primase activity
AltI4_RS17840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AltI4_RS17860	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AltI4_RS17865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AltI4_RS17880	COG1960	acyl-CoA dehydrogenase activity
AltI4_RS17900	COG0348	domain, Protein
AltI4_RS17905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AltI4_RS17915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AltI4_RS17920	COG3710	Transcriptional regulator
AltI4_RS17940	COG0659	secondary active sulfate transmembrane transporter activity
AltI4_RS17955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AltI4_RS17965	COG0271	Belongs to the BolA IbaG family
AltI4_RS18040	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AltI4_RS18060	COG2234	aminopeptidase activity
AltI4_RS18095	COG0583	DNA-binding transcription factor activity
AltI4_RS18100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AltI4_RS18110	COG1960	acyl-CoA dehydrogenase activity
AltI4_RS18115	COG1522	sequence-specific DNA binding
AltI4_RS18130	COG1278	Cold shock
AltI4_RS18135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AltI4_RS18145	COG2226	methyltransferase
AltI4_RS18160	COG0339	signal peptide processing
AltI4_RS18165	COG2203	Gaf domain
AltI4_RS18165	COG2200	EAL domain
AltI4_RS18165	COG2199	diguanylate cyclase activity
AltI4_RS18170	COG2201	protein-glutamate methylesterase activity
AltI4_RS18180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AltI4_RS18180	COG4191	Histidine kinase
AltI4_RS18190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AltI4_RS18200	COG0784	Response regulator, receiver
AltI4_RS18200	COG3437	response regulator, receiver
AltI4_RS18205	COG0402	S-adenosylhomocysteine deaminase activity
AltI4_RS18225	COG1695	Transcriptional regulator
AltI4_RS18250	COG2197	response regulator
AltI4_RS18270	COG3093	addiction module antidote protein HigA
AltI4_RS18285	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AltI4_RS18290	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AltI4_RS18295	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AltI4_RS18305	COG0281	malic enzyme
AltI4_RS18315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AltI4_RS18345	COG0456	acetyltransferase
AltI4_RS18355	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AltI4_RS18360	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AltI4_RS18365	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AltI4_RS18370	COG2177	Part of the ABC transporter FtsEX involved in
AltI4_RS18375	COG2884	Cell division ATP-binding protein ftsE
AltI4_RS18380	COG0552	protein localization to endoplasmic reticulum
AltI4_RS18385	COG0742	ribosomal rna small subunit methyltransferase
AltI4_RS18395	COG2095	MarC family integral membrane protein
AltI4_RS18415	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AltI4_RS18420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AltI4_RS18425	COG0617	tRNA 3'-terminal CCA addition
AltI4_RS18440	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AltI4_RS18445	COG0784	Response regulator, receiver
AltI4_RS18445	COG2205	protein histidine kinase activity
AltI4_RS18450	COG0076	glutamate decarboxylase activity
AltI4_RS18455	COG4106	trans-aconitate 2-methyltransferase activity
AltI4_RS18460	COG0842	Transport permease protein
AltI4_RS18465	COG1131	(ABC) transporter
AltI4_RS18470	COG2205	protein histidine kinase activity
AltI4_RS18470	COG0784	Response regulator, receiver
AltI4_RS18470	COG5002	protein histidine kinase activity
AltI4_RS18480	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AltI4_RS18480	COG2885	chlorophyll binding
AltI4_RS18485	COG0745	RESPONSE REGULATOR receiver
AltI4_RS18490	COG2205	protein histidine kinase activity
AltI4_RS18495	COG1253	flavin adenine dinucleotide binding
AltI4_RS18500	COG1966	Carbon starvation protein
AltI4_RS18505	COG5001	Diguanylate cyclase
AltI4_RS18505	COG3300	MHYT domain
AltI4_RS18525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AltI4_RS18530	COG0049	tRNA binding
AltI4_RS18535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AltI4_RS18540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AltI4_RS18545	COG0085	RNA polymerase activity
AltI4_RS18550	COG0222	ribosome binding
AltI4_RS18555	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AltI4_RS18560	COG0081	regulation of translation
AltI4_RS18565	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AltI4_RS18570	COG0250	Participates in transcription elongation, termination and antitermination
AltI4_RS18575	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AltI4_RS18590	COG1960	acyl-CoA dehydrogenase activity
AltI4_RS18600	COG1132	(ABC) transporter
AltI4_RS18605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AltI4_RS18615	COG0251	oxidation-reduction process
AltI4_RS18620	COG2010	Cytochrome c
AltI4_RS18640	COG0513	Belongs to the DEAD box helicase family
AltI4_RS18645	COG0418	dihydroorotase activity
AltI4_RS18650	COG0243	molybdopterin cofactor binding
AltI4_RS18665	COG3040	lipid binding
AltI4_RS18670	COG4989	oxidoreductase activity
AltI4_RS18675	COG0346	lactoylglutathione lyase activity
AltI4_RS18680	COG1940	carbohydrate kinase activity
AltI4_RS18685	COG2211	Major facilitator Superfamily
AltI4_RS18700	COG0302	gtp cyclohydrolase
AltI4_RS18705	COG1028	Short-chain dehydrogenase reductase Sdr
AltI4_RS18710	COG2957	Belongs to the agmatine deiminase family
AltI4_RS18725	COG1201	RNA secondary structure unwinding
AltI4_RS18745	COG1793	dna ligase
AltI4_RS18755	COG1028	Short-chain dehydrogenase reductase Sdr
AltI4_RS18790	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AltI4_RS18800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AltI4_RS18815	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AltI4_RS18820	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AltI4_RS18825	COG0330	HflC and HflK could
AltI4_RS18830	COG0330	HflC and HflK could
AltI4_RS18835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AltI4_RS18840	COG1923	regulation of RNA biosynthetic process
AltI4_RS18845	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AltI4_RS18860	COG0802	atpase or kinase
AltI4_RS18865	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AltI4_RS18865	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AltI4_RS18870	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AltI4_RS18885	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AltI4_RS18890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AltI4_RS18900	COG2022	thiamine diphosphate biosynthetic process
AltI4_RS18915	COG0351	phosphomethylpyrimidine kinase
AltI4_RS18930	COG1522	sequence-specific DNA binding
AltI4_RS18945	COG0735	belongs to the Fur family
AltI4_RS19010	COG2258	MOSC domain
AltI4_RS19090	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AltI4_RS19140	COG2211	Major facilitator Superfamily
AltI4_RS19150	COG0673	inositol 2-dehydrogenase activity
AltI4_RS19155	COG1609	Transcriptional regulator
AltI4_RS19205	COG2971	BadF BadG BcrA BcrD
AltI4_RS19210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AltI4_RS19215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AltI4_RS19225	COG0840	transmembrane signaling receptor activity
AltI4_RS19230	COG3547	Transposase (IS116 IS110 IS902 family)
AltI4_RS19235	COG1309	transcriptional regulator
AltI4_RS19240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AltI4_RS19245	COG1335	isochorismatase
AltI4_RS19250	COG0251	oxidation-reduction process
AltI4_RS19255	COG0596	Alpha beta hydrolase
AltI4_RS19260	COG0778	Nitroreductase
AltI4_RS19265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AltI4_RS19280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AltI4_RS19290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AltI4_RS19295	COG1349	DNA-binding transcription factor activity
AltI4_RS19300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AltI4_RS19305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AltI4_RS19310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AltI4_RS19325	COG1621	beta-fructofuranosidase activity
AltI4_RS19330	COG2814	Major facilitator Superfamily
AltI4_RS19340	COG4771	TonB-dependent receptor
AltI4_RS19365	COG1476	TRANSCRIPTIONal
AltI4_RS19380	COG3609	addiction module antidote protein, CC2985 family
AltI4_RS19395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AltI4_RS19415	COG1175	transmembrane transport
AltI4_RS19425	COG3659	wide pore channel activity
AltI4_RS19435	COG0246	Mannitol dehydrogenase
AltI4_RS19450	COG1595	DNA-templated transcription, initiation
AltI4_RS19475	COG0436	Aminotransferase
AltI4_RS19485	COG0626	cystathionine gamma-synthase activity
AltI4_RS19490	COG1757	Na H antiporter
AltI4_RS19500	COG0840	transmembrane signaling receptor activity
AltI4_RS19505	COG0348	domain, Protein
AltI4_RS19510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AltI4_RS19545	COG4774	siderophore transport
AltI4_RS19575	COG2972	Histidine kinase
AltI4_RS19580	COG1131	(ABC) transporter
AltI4_RS19595	COG0604	alcohol dehydrogenase
AltI4_RS19605	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AltI4_RS19620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AltI4_RS19630	COG0297	glycogen (starch) synthase activity
AltI4_RS19640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AltI4_RS19640	COG4191	Histidine kinase
AltI4_RS19645	COG0745	RESPONSE REGULATOR receiver
AltI4_RS19660	COG0312	modulator of DNA gyrase
AltI4_RS19665	COG3028	Belongs to the UPF0307 family
AltI4_RS19670	COG0312	modulator of DNA gyrase
AltI4_RS19675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AltI4_RS19680	COG3164	Protein of unknown function
AltI4_RS19685	COG1530	ribonuclease E activity
AltI4_RS19690	COG0424	maF-like protein
AltI4_RS19695	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AltI4_RS19700	COG1792	Involved in formation and maintenance of cell shape
AltI4_RS19705	COG1077	Cell shape determining protein MreB Mrl
AltI4_RS19735	COG2165	general secretion pathway protein
AltI4_RS19740	COG2165	general secretion pathway protein
AltI4_RS19750	COG1459	type II secretion system
AltI4_RS19755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AltI4_RS19765	COG3409	Peptidoglycan-binding domain 1 protein
AltI4_RS19765	COG3267	Type II secretory pathway component ExeA
AltI4_RS19795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AltI4_RS19810	COG3243	poly(R)-hydroxyalkanoic acid synthase
AltI4_RS19820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AltI4_RS19840	COG0189	ligase activity
AltI4_RS19850	COG1595	DNA-templated transcription, initiation
AltI4_RS19865	COG2239	Acts as a magnesium transporter
AltI4_RS19885	COG0629	single-stranded DNA binding
AltI4_RS19920	COG1674	ftsk spoiiie
AltI4_RS19920	COG1196	nuclear chromosome segregation
AltI4_RS19925	COG4191	Histidine kinase
AltI4_RS19935	COG1484	DNA-dependent DNA replication
AltI4_RS19940	COG4584	PFAM Integrase catalytic
AltI4_RS19965	COG1104	cysteine desulfurase activity
AltI4_RS20000	COG3250	beta-galactosidase activity
AltI4_RS20005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AltI4_RS20040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AltI4_RS20045	COG1085	galactose-1-phosphate uridylyltransferase
AltI4_RS20055	COG1609	Transcriptional regulator
AltI4_RS20075	COG2186	Transcriptional regulator
AltI4_RS20090	COG4771	TonB-dependent receptor
AltI4_RS20100	COG3940	Belongs to the glycosyl hydrolase 43 family
AltI4_RS20105	COG3507	Belongs to the glycosyl hydrolase 43 family
AltI4_RS20110	COG0471	metal ion transport
AltI4_RS20110	COG0490	domain, Protein
AltI4_RS20130	COG1349	DNA-binding transcription factor activity
AltI4_RS20135	COG2223	nitrite transmembrane transporter activity
AltI4_RS20160	COG0523	cobalamin synthesis protein
AltI4_RS20170	COG0577	efflux transmembrane transporter activity
AltI4_RS20170	COG1136	(ABC) transporter
AltI4_RS20205	COG0545	Peptidyl-prolyl cis-trans isomerase
AltI4_RS20240	COG1279	arginine transmembrane transporter activity
AltI4_RS20265	COG3668	Plasmid stabilization system
AltI4_RS20290	COG3940	Belongs to the glycosyl hydrolase 43 family
AltI4_RS20295	COG2211	Major facilitator Superfamily
AltI4_RS20305	COG3507	Belongs to the glycosyl hydrolase 43 family
AltI4_RS20320	COG3148	PFAM DTW domain containing protein
AltI4_RS20325	COG4774	siderophore transport
AltI4_RS20340	COG3940	Belongs to the glycosyl hydrolase 43 family
AltI4_RS20345	COG1082	Xylose isomerase domain protein TIM barrel
AltI4_RS20355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AltI4_RS20375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AltI4_RS20380	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AltI4_RS20385	COG0346	lactoylglutathione lyase activity
AltI4_RS20400	COG2814	Major facilitator Superfamily
AltI4_RS20405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AltI4_RS20425	COG0004	ammonium transporteR
AltI4_RS20430	COG3507	Belongs to the glycosyl hydrolase 43 family
AltI4_RS20455	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AltI4_RS20460	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AltI4_RS20465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AltI4_RS20470	COG0163	prenyltransferase activity
AltI4_RS20485	COG0671	phosphoesterase, PA-phosphatase related
AltI4_RS20500	COG0019	diaminopimelate decarboxylase activity
AltI4_RS20505	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AltI4_RS20520	COG1011	Hydrolase
AltI4_RS20530	COG0210	DNA helicase
AltI4_RS20545	COG0534	Mate efflux family protein
AltI4_RS20555	COG2962	Rard protein
AltI4_RS20560	COG2239	Acts as a magnesium transporter
AltI4_RS20565	COG0514	ATP-dependent DNA helicase (RecQ)
AltI4_RS20575	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AltI4_RS20590	COG3064	Membrane
AltI4_RS20605	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AltI4_RS20605	COG3264	Mechanosensitive ion channel
AltI4_RS20630	COG0123	including yeast histone deacetylase and acetoin utilization protein
AltI4_RS20635	COG0427	acetyl-CoA hydrolase
AltI4_RS20650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AltI4_RS20710	COG3038	cytochrome b561
AltI4_RS20735	COG1252	NADH dehydrogenase
AltI4_RS20755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AltI4_RS20770	COG0784	Response regulator, receiver
AltI4_RS20770	COG2205	protein histidine kinase activity
AltI4_RS20790	COG1131	(ABC) transporter
AltI4_RS20820	COG3901	Regulator of nitric oxide reductase transcription
AltI4_RS20820	COG0348	domain, Protein
AltI4_RS20830	COG3550	peptidyl-serine autophosphorylation
AltI4_RS20835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AltI4_RS20840	COG2205	protein histidine kinase activity
AltI4_RS20845	COG0745	RESPONSE REGULATOR receiver
AltI4_RS20850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AltI4_RS20860	COG1538	Outer membrane efflux protein
AltI4_RS20905	COG4774	siderophore transport
AltI4_RS20930	COG5002	protein histidine kinase activity
AltI4_RS20935	COG0745	RESPONSE REGULATOR receiver
AltI4_RS20960	COG1505	serine-type exopeptidase activity
AltI4_RS20970	COG0583	DNA-binding transcription factor activity
AltI4_RS20975	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AltI4_RS20995	COG1522	sequence-specific DNA binding
AltI4_RS21000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AltI4_RS21040	COG1473	amidohydrolase
AltI4_RS21075	COG4172	Belongs to the ABC transporter superfamily
AltI4_RS21080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AltI4_RS21085	COG0601	transmembrane transport
AltI4_RS21095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AltI4_RS21115	COG1012	belongs to the aldehyde dehydrogenase family
AltI4_RS21150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AltI4_RS21155	COG1349	DNA-binding transcription factor activity
AltI4_RS21165	COG0673	inositol 2-dehydrogenase activity
AltI4_RS21170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AltI4_RS21175	COG2199	diguanylate cyclase activity
AltI4_RS21180	COG0697	spore germination
AltI4_RS21185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AltI4_RS21200	COG1166	arginine decarboxylase activity
AltI4_RS21225	COG1522	sequence-specific DNA binding
AltI4_RS21230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AltI4_RS21235	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AltI4_RS21250	COG0612	Peptidase, M16
AltI4_RS21255	COG3344	reverse transcriptase
AltI4_RS21275	COG4677	pectinesterase activity
AltI4_RS21295	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AltI4_RS21300	COG4771	TonB-dependent receptor
AltI4_RS21305	COG2755	lipolytic protein G-D-S-L family
AltI4_RS21315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AltI4_RS21320	COG0800	Aldolase
AltI4_RS21325	COG0246	Mannitol dehydrogenase
AltI4_RS21330	COG1904	glucuronate isomerase
AltI4_RS21335	COG2721	sulfolactate sulfo-lyase activity
AltI4_RS21340	COG1609	Transcriptional regulator
AltI4_RS21360	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AltI4_RS21365	COG1028	Short-chain dehydrogenase reductase Sdr
AltI4_RS21380	COG1324	tolerance protein
AltI4_RS21385	COG4232	protein-disulfide reductase activity
AltI4_RS21390	COG0840	transmembrane signaling receptor activity
AltI4_RS21405	COG0745	RESPONSE REGULATOR receiver
AltI4_RS21410	COG2198	Histidine kinase
AltI4_RS21410	COG0643	Histidine kinase
AltI4_RS21415	COG0835	chemotaxis
AltI4_RS21430	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AltI4_RS21435	COG2201	protein-glutamate methylesterase activity
AltI4_RS21440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AltI4_RS21445	COG0511	ligase activity, forming carbon-carbon bonds
AltI4_RS21450	COG0439	Biotin carboxylase
AltI4_RS21495	COG0154	amidase activity
AltI4_RS21510	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AltI4_RS21525	COG0151	Belongs to the GarS family
AltI4_RS21540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AltI4_RS21545	COG3954	Phosphoribulokinase
AltI4_RS21550	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AltI4_RS21570	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AltI4_RS21575	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AltI4_RS21580	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AltI4_RS21585	COG3031	protein transport across the cell outer membrane
AltI4_RS21595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AltI4_RS21600	COG1459	type II secretion system
AltI4_RS21605	COG2165	general secretion pathway protein
AltI4_RS21620	COG4795	General secretion pathway protein
AltI4_RS21625	COG3156	type II secretion system protein K
AltI4_RS21635	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AltI4_RS21650	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AltI4_RS21655	COG1011	Hydrolase
AltI4_RS21660	COG0494	nUDIX hydrolase
AltI4_RS21665	COG1218	3'(2'),5'-bisphosphate nucleotidase
AltI4_RS21670	COG2353	YceI-like domain
AltI4_RS21675	COG2943	transferase activity, transferring hexosyl groups
AltI4_RS21680	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AltI4_RS21695	COG0429	hydrolase of the alpha beta-hydrolase fold
AltI4_RS21705	COG0488	(ABC) transporter
AltI4_RS21725	COG2268	Band 7 protein
AltI4_RS21730	COG1278	Cold shock
AltI4_RS21740	COG3177	Filamentation induced by cAMP protein fic
AltI4_RS21750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AltI4_RS21755	COG2900	Belongs to the SlyX family
AltI4_RS21765	COG0545	Peptidyl-prolyl cis-trans isomerase
AltI4_RS21775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AltI4_RS21795	COG2183	response to ionizing radiation
AltI4_RS21810	COG0596	Alpha beta hydrolase
AltI4_RS21815	COG1040	competence protein
AltI4_RS21835	COG0534	Mate efflux family protein
AltI4_RS21840	COG0726	polysaccharide deacetylase
AltI4_RS21840	COG1649	PFAM Uncharacterised BCR, COG1649
AltI4_RS21855	COG0109	protoheme IX farnesyltransferase activity
AltI4_RS21860	COG1612	heme a metabolic process
AltI4_RS21885	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AltI4_RS21890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AltI4_RS21895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AltI4_RS21910	COG0500	methyltransferase
AltI4_RS21925	COG3706	GGDEF domain
AltI4_RS21960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AltI4_RS21965	COG1414	Transcriptional regulator
AltI4_RS21970	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AltI4_RS21975	COG1028	Short-chain dehydrogenase reductase Sdr
AltI4_RS21990	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AltI4_RS22010	COG3254	rhamnose metabolic process
AltI4_RS22015	COG1874	Beta-galactosidase
AltI4_RS22045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AltI4_RS22050	COG0129	dihydroxy-acid dehydratase activity
AltI4_RS22060	COG0606	chelatase, subunit chli
AltI4_RS22080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AltI4_RS22090	COG2814	Major facilitator Superfamily
AltI4_RS22095	COG3507	Belongs to the glycosyl hydrolase 43 family
AltI4_RS22105	COG2326	polyphosphate kinase activity
AltI4_RS22120	COG2911	Protein conserved in bacteria
AltI4_RS22140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AltI4_RS22150	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AltI4_RS22155	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AltI4_RS22175	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AltI4_RS22205	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AltI4_RS22220	COG1228	amidohydrolase
AltI4_RS22250	COG1561	YicC-like family, N-terminal region
AltI4_RS22260	COG3550	peptidyl-serine autophosphorylation
AltI4_RS22270	COG2153	protein acetylation
AltI4_RS22295	COG2211	Major facilitator Superfamily
AltI4_RS22300	COG1609	Transcriptional regulator
AltI4_RS22315	COG0840	transmembrane signaling receptor activity
AltI4_RS22330	COG2199	diguanylate cyclase activity
AltI4_RS22330	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AltI4_RS22365	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AltI4_RS22385	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AltI4_RS22390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AltI4_RS22400	COG0356	it plays a direct role in the translocation of protons across the membrane
AltI4_RS22410	COG1475	DNA binding
AltI4_RS22415	COG1192	Involved in chromosome partitioning
AltI4_RS22440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AltI4_RS22455	COG0706	membrane insertase activity
AltI4_RS22460	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AltI4_RS22465	COG0594	ribonuclease P activity
AltI4_RS22470	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AltI4_RS22540	COG4771	TonB-dependent receptor
AltI4_RS22555	COG1960	acyl-CoA dehydrogenase activity
AltI4_RS22560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AltI4_RS22565	COG1024	Enoyl-CoA hydratase
AltI4_RS22575	COG0183	Belongs to the thiolase family
AltI4_RS22585	COG1024	Enoyl-CoA hydratase
AltI4_RS22590	COG1024	Enoyl-CoA hydratase
AltI4_RS22600	COG2814	Major facilitator Superfamily
AltI4_RS22610	COG0183	Belongs to the thiolase family
AltI4_RS22635	COG1472	Belongs to the glycosyl hydrolase 3 family
AltI4_RS22640	COG2211	Major facilitator Superfamily
AltI4_RS22650	COG2272	Belongs to the type-B carboxylesterase lipase family
AltI4_RS22655	COG2186	Transcriptional regulator
AltI4_RS22670	COG1960	acyl-CoA dehydrogenase activity
AltI4_RS22680	COG4206	TonB-dependent receptor
AltI4_RS22685	COG1472	Belongs to the glycosyl hydrolase 3 family
AltI4_RS22695	COG3507	Belongs to the glycosyl hydrolase 43 family
AltI4_RS22720	COG1192	Involved in chromosome partitioning
AltI4_RS22730	COG3250	beta-galactosidase activity
AltI4_RS22735	COG4206	TonB-dependent receptor
AltI4_RS22740	COG3250	beta-galactosidase activity
AltI4_RS22745	COG4771	TonB-dependent receptor
AltI4_RS22790	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AltI4_RS22795	COG2971	BadF BadG BcrA BcrD
AltI4_RS22800	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AltI4_RS22805	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AltI4_RS22825	COG0179	Fumarylacetoacetate (FAA) hydrolase
AltI4_RS22830	COG1028	Short-chain dehydrogenase reductase Sdr
AltI4_RS22840	COG1028	Short-chain dehydrogenase reductase Sdr
AltI4_RS22850	COG0129	dihydroxy-acid dehydratase activity
AltI4_RS22860	COG1250	3-hydroxyacyl-CoA dehydrogenase
AltI4_RS22860	COG1024	Enoyl-CoA hydratase