locus-tag	class	description
JN178_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JN178_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JN178_RS00020	COG0187	DNA topoisomerase II activity
JN178_RS00050	COG2818	Glycosylase
JN178_RS00060	COG3078	GTPase activator activity
JN178_RS00080	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JN178_RS00080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JN178_RS00085	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
JN178_RS00090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JN178_RS00095	COG0569	domain protein
JN178_RS00100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JN178_RS00100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JN178_RS00105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JN178_RS00120	COG0758	DNA mediated transformation
JN178_RS00135	COG0009	L-threonylcarbamoyladenylate synthase
JN178_RS00140	COG0408	coproporphyrinogen oxidase activity
JN178_RS00145	COG3047	cAMP biosynthetic process
JN178_RS00160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JN178_RS00225	COG2234	aminopeptidase activity
JN178_RS00230	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JN178_RS00230	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JN178_RS00245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JN178_RS00270	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JN178_RS00300	COG3642	lipopolysaccharide core region biosynthetic process
JN178_RS00305	COG0859	PFAM glycosyl transferase family 9
JN178_RS00335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JN178_RS00350	COG3161	chorismate lyase activity
JN178_RS00355	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JN178_RS00375	COG0210	DNA helicase
JN178_RS00395	COG1028	Short-chain dehydrogenase reductase Sdr
JN178_RS00435	COG1595	DNA-templated transcription, initiation
JN178_RS00440	COG0318	PFAM AMP-dependent synthetase and ligase
JN178_RS00460	COG1024	Enoyl-CoA hydratase
JN178_RS00465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JN178_RS00475	COG1960	acyl-CoA dehydrogenase activity
JN178_RS00485	COG4191	Histidine kinase
JN178_RS00500	COG1136	(ABC) transporter
JN178_RS00505	COG0577	efflux transmembrane transporter activity
JN178_RS00510	COG3706	GGDEF domain
JN178_RS00515	COG0745	RESPONSE REGULATOR receiver
JN178_RS00520	COG2205	protein histidine kinase activity
JN178_RS00530	COG0793	Belongs to the peptidase S41A family
JN178_RS00540	COG4773	Receptor
JN178_RS00550	COG1960	acyl-CoA dehydrogenase activity
JN178_RS00555	COG0583	DNA-binding transcription factor activity
JN178_RS00565	COG3106	COG3106 Predicted ATPase
JN178_RS00585	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JN178_RS00605	COG0352	thiamine-phosphate diphosphorylase activity
JN178_RS00615	COG3071	HemY protein
JN178_RS00620	COG2959	enzyme of heme biosynthesis
JN178_RS00630	COG0181	hydroxymethylbilane synthase activity
JN178_RS00645	COG0194	GDP metabolic process
JN178_RS00655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JN178_RS00665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JN178_RS00680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JN178_RS00690	COG0678	peroxiredoxin activity
JN178_RS00705	COG1178	ABC-type Fe3 transport system permease component
JN178_RS00710	COG3842	ATPase activity
JN178_RS00715	COG2081	HI0933 family
JN178_RS00740	COG3706	GGDEF domain
JN178_RS00750	COG0583	DNA-binding transcription factor activity
JN178_RS00770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JN178_RS00785	COG0427	acetyl-CoA hydrolase
JN178_RS00790	COG0123	including yeast histone deacetylase and acetoin utilization protein
JN178_RS00805	COG0840	transmembrane signaling receptor activity
JN178_RS00815	COG3064	Membrane
JN178_RS00825	COG5001	Diguanylate cyclase
JN178_RS00825	COG5002	protein histidine kinase activity
JN178_RS00840	COG0514	ATP-dependent DNA helicase (RecQ)
JN178_RS00845	COG2050	protein possibly involved in aromatic compounds catabolism
JN178_RS00850	COG2239	Acts as a magnesium transporter
JN178_RS00855	COG2962	Rard protein
JN178_RS00865	COG0210	DNA helicase
JN178_RS00880	COG1011	Hydrolase
JN178_RS00885	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JN178_RS00895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JN178_RS00900	COG0019	diaminopimelate decarboxylase activity
JN178_RS00930	COG0163	prenyltransferase activity
JN178_RS00935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JN178_RS00945	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JN178_RS00960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JN178_RS00985	COG0577	efflux transmembrane transporter activity
JN178_RS00985	COG1136	(ABC) transporter
JN178_RS00995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JN178_RS01010	COG4555	ABC transporter
JN178_RS01060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JN178_RS01065	COG2814	Major facilitator Superfamily
JN178_RS01070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JN178_RS01095	COG1085	galactose-1-phosphate uridylyltransferase
JN178_RS01100	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JN178_RS01110	COG0629	single-stranded DNA binding
JN178_RS01135	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JN178_RS01160	COG1349	DNA-binding transcription factor activity
JN178_RS01180	COG1077	Cell shape determining protein MreB Mrl
JN178_RS01185	COG1792	Involved in formation and maintenance of cell shape
JN178_RS01190	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
JN178_RS01195	COG0424	maF-like protein
JN178_RS01200	COG1530	ribonuclease E activity
JN178_RS01210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JN178_RS01215	COG0312	modulator of DNA gyrase
JN178_RS01230	COG2205	protein histidine kinase activity
JN178_RS01230	COG0784	Response regulator, receiver
JN178_RS01235	COG3028	Belongs to the UPF0307 family
JN178_RS01240	COG0312	modulator of DNA gyrase
JN178_RS01245	COG2207	Transcriptional regulator
JN178_RS01255	COG0745	RESPONSE REGULATOR receiver
JN178_RS01260	COG4191	Histidine kinase
JN178_RS01260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN178_RS01265	COG0297	glycogen (starch) synthase activity
JN178_RS01275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JN178_RS01310	COG0840	transmembrane signaling receptor activity
JN178_RS01315	COG0745	RESPONSE REGULATOR receiver
JN178_RS01320	COG2198	Histidine kinase
JN178_RS01320	COG0643	Histidine kinase
JN178_RS01325	COG0835	chemotaxis
JN178_RS01360	COG1595	DNA-templated transcription, initiation
JN178_RS01375	COG0784	Response regulator, receiver
JN178_RS01375	COG2205	protein histidine kinase activity
JN178_RS01400	COG0784	Response regulator, receiver
JN178_RS01400	COG2205	protein histidine kinase activity
JN178_RS01415	COG1609	Transcriptional regulator
JN178_RS01520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JN178_RS01540	COG0089	rRNA binding
JN178_RS01550	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JN178_RS01560	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JN178_RS01575	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JN178_RS01580	COG0297	glycogen (starch) synthase activity
JN178_RS01590	COG1519	Transferase
JN178_RS01610	COG0840	transmembrane signaling receptor activity
JN178_RS01630	COG0788	formyltetrahydrofolate deformylase activity
JN178_RS01640	COG1643	Atp-dependent helicase
JN178_RS01645	COG2951	lytic endotransglycosylase activity
JN178_RS01650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JN178_RS01660	COG2354	Protein conserved in bacteria
JN178_RS01685	COG0004	ammonium transporteR
JN178_RS01690	COG0405	Gamma-glutamyltransferase
JN178_RS01695	COG2837	iron assimilation
JN178_RS01705	COG0540	Belongs to the ATCase OTCase family
JN178_RS01715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JN178_RS01730	COG5002	protein histidine kinase activity
JN178_RS01730	COG2205	protein histidine kinase activity
JN178_RS01730	COG0784	Response regulator, receiver
JN178_RS01745	COG3300	MHYT domain
JN178_RS01745	COG5001	Diguanylate cyclase
JN178_RS01755	COG1012	belongs to the aldehyde dehydrogenase family
JN178_RS01765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JN178_RS01780	COG0180	Tryptophanyl-tRNA synthetase
JN178_RS01785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JN178_RS01805	COG0338	D12 class N6 adenine-specific DNA methyltransferase
JN178_RS01815	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JN178_RS01850	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JN178_RS01855	COG0281	malic enzyme
JN178_RS01865	COG0625	glutathione transferase activity
JN178_RS01890	COG5001	Diguanylate cyclase
JN178_RS01890	COG3300	MHYT domain
JN178_RS01895	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JN178_RS01895	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JN178_RS01905	COG0137	argininosuccinate synthase activity
JN178_RS01910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JN178_RS01925	COG1803	Methylglyoxal synthase
JN178_RS01935	COG0745	RESPONSE REGULATOR receiver
JN178_RS01940	COG2205	protein histidine kinase activity
JN178_RS01945	COG2267	carboxylic ester hydrolase activity
JN178_RS01950	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JN178_RS01955	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JN178_RS01965	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JN178_RS01970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JN178_RS01975	COG4942	peptidase
JN178_RS01980	COG2861	carbohydrate metabolic process
JN178_RS01990	COG0584	glycerophosphoryl diester phosphodiesterase
JN178_RS02005	COG1162	GTPase activity
JN178_RS02010	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JN178_RS02030	COG0457	Tetratricopeptide repeat
JN178_RS02045	COG0028	Belongs to the TPP enzyme family
JN178_RS02055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JN178_RS02060	COG1288	antiporter activity
JN178_RS02065	COG4206	TonB-dependent receptor
JN178_RS02085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JN178_RS02090	COG0805	protein transport
JN178_RS02100	COG0084	hydrolase, TatD family'
JN178_RS02105	COG3706	GGDEF domain
JN178_RS02105	COG2203	Gaf domain
JN178_RS02105	COG5001	Diguanylate cyclase
JN178_RS02105	COG4251	negative regulation of phosphorylation
JN178_RS02115	COG0248	Ppx GppA phosphatase
JN178_RS02120	COG0513	Belongs to the DEAD box helicase family
JN178_RS02125	COG3118	belongs to the thioredoxin family
JN178_RS02130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JN178_RS02135	COG1473	amidohydrolase
JN178_RS02140	COG5002	protein histidine kinase activity
JN178_RS02140	COG0784	Response regulator, receiver
JN178_RS02145	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JN178_RS02150	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JN178_RS02155	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JN178_RS02170	COG0783	Belongs to the Dps family
JN178_RS02175	COG2133	pyrroloquinoline quinone binding
JN178_RS02180	COG0823	Involved in the tonB-independent uptake of proteins
JN178_RS02180	COG1506	peptidase
JN178_RS02180	COG4946	Tricorn protease homolog
JN178_RS02190	COG3118	belongs to the thioredoxin family
JN178_RS02205	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
JN178_RS02215	COG1012	belongs to the aldehyde dehydrogenase family
JN178_RS02240	COG1757	Na H antiporter
JN178_RS02255	COG3876	Protein conserved in bacteria
JN178_RS02260	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JN178_RS02280	COG0346	lactoylglutathione lyase activity
JN178_RS02310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JN178_RS02320	COG2824	Alkylphosphonate utilization operon protein PhnA
JN178_RS02325	COG0454	-acetyltransferase
JN178_RS02450	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JN178_RS02475	COG3547	Transposase (IS116 IS110 IS902 family)
JN178_RS02505	COG3547	Transposase (IS116 IS110 IS902 family)
JN178_RS02540	COG3547	Transposase (IS116 IS110 IS902 family)
JN178_RS02550	COG0183	Belongs to the thiolase family
JN178_RS02555	COG1024	Enoyl-CoA hydratase
JN178_RS02555	COG1250	3-hydroxyacyl-CoA dehydrogenase
JN178_RS02560	COG0739	heme binding
JN178_RS02560	COG0741	lytic transglycosylase activity
JN178_RS02560	COG1196	nuclear chromosome segregation
JN178_RS02565	COG0006	proline dipeptidase activity
JN178_RS02575	COG0142	geranyltranstransferase activity
JN178_RS02600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JN178_RS02605	COG4942	peptidase
JN178_RS02605	COG1388	LysM domain
JN178_RS02610	COG1238	metal cluster binding
JN178_RS02620	COG0585	pseudouridine synthase activity
JN178_RS02625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JN178_RS02635	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
JN178_RS02645	COG0840	transmembrane signaling receptor activity
JN178_RS02650	COG1522	sequence-specific DNA binding
JN178_RS02655	COG1063	alcohol dehydrogenase
JN178_RS02685	COG0494	nUDIX hydrolase
JN178_RS02690	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
JN178_RS02695	COG0730	response to heat
JN178_RS02700	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JN178_RS02705	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JN178_RS02715	COG3706	GGDEF domain
JN178_RS02720	COG3437	response regulator, receiver
JN178_RS02720	COG2205	protein histidine kinase activity
JN178_RS02720	COG4999	Histidine kinase
JN178_RS02720	COG3850	Histidine kinase
JN178_RS02725	COG2211	Major facilitator Superfamily
JN178_RS02740	COG0564	pseudouridine synthase activity
JN178_RS02745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JN178_RS02755	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JN178_RS02760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JN178_RS02775	COG1648	precorrin-2 dehydrogenase activity
JN178_RS02775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JN178_RS02780	COG0513	Belongs to the DEAD box helicase family
JN178_RS02800	COG1538	Outer membrane efflux protein
JN178_RS02805	COG0494	nUDIX hydrolase
JN178_RS02820	COG3150	esterase
JN178_RS02850	COG1509	lysine 2,3-aminomutase activity
JN178_RS02855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JN178_RS02860	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
JN178_RS02880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JN178_RS02900	COG0271	Belongs to the BolA IbaG family
JN178_RS02905	COG0671	phosphoesterase, PA-phosphatase related
JN178_RS02915	COG3707	response regulator
JN178_RS02925	COG0659	secondary active sulfate transmembrane transporter activity
JN178_RS02930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JN178_RS02935	COG2146	nitrite reductase [NAD(P)H] activity
JN178_RS02940	COG0243	molybdopterin cofactor binding
JN178_RS02945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JN178_RS02945	COG1648	precorrin-2 dehydrogenase activity
JN178_RS02950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JN178_RS02960	COG3706	GGDEF domain
JN178_RS02970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JN178_RS02970	COG1116	anion transmembrane transporter activity
JN178_RS02980	COG1116	anion transmembrane transporter activity
JN178_RS02990	COG0746	molybdenum cofactor guanylyltransferase activity
JN178_RS03000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JN178_RS03005	COG4206	TonB-dependent receptor
JN178_RS03010	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JN178_RS03015	COG0348	domain, Protein
JN178_RS03030	COG1960	acyl-CoA dehydrogenase activity
JN178_RS03035	COG1028	Short-chain dehydrogenase reductase Sdr
JN178_RS03040	COG3618	amidohydrolase
JN178_RS03045	COG4948	Mandelate Racemase Muconate Lactonizing
JN178_RS03065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JN178_RS03085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JN178_RS03090	COG0358	DNA primase activity
JN178_RS03115	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JN178_RS03120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JN178_RS03135	COG0537	adenosine 5'-monophosphoramidase activity
JN178_RS03150	COG3135	benzoate transporter
JN178_RS03155	COG1396	sequence-specific DNA binding
JN178_RS03160	COG2974	May be involved in recombination
JN178_RS03165	COG4191	Histidine kinase
JN178_RS03165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN178_RS03170	COG0745	RESPONSE REGULATOR receiver
JN178_RS03175	COG5002	protein histidine kinase activity
JN178_RS03205	COG0811	peptide transport
JN178_RS03210	COG0811	peptide transport
JN178_RS03215	COG0848	biopolymer transport protein
JN178_RS03220	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
JN178_RS03230	COG3437	response regulator, receiver
JN178_RS03235	COG5002	protein histidine kinase activity
JN178_RS03235	COG2205	protein histidine kinase activity
JN178_RS03235	COG0784	Response regulator, receiver
JN178_RS03255	COG2133	pyrroloquinoline quinone binding
JN178_RS03260	COG1049	propionate catabolic process, 2-methylcitrate cycle
JN178_RS03270	COG4999	Histidine kinase
JN178_RS03270	COG3437	response regulator, receiver
JN178_RS03270	COG2205	protein histidine kinase activity
JN178_RS03270	COG3850	Histidine kinase
JN178_RS03275	COG2819	hydrolase of the alpha beta superfamily
JN178_RS03290	COG1793	dna ligase
JN178_RS03300	COG0527	aspartate kinase activity
JN178_RS03305	COG5001	Diguanylate cyclase
JN178_RS03305	COG4251	negative regulation of phosphorylation
JN178_RS03305	COG3706	GGDEF domain
JN178_RS03305	COG2203	Gaf domain
JN178_RS03315	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JN178_RS03320	COG2967	ApaG domain
JN178_RS03330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JN178_RS03335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JN178_RS03340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
JN178_RS03345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JN178_RS03355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JN178_RS03360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JN178_RS03375	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JN178_RS03390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JN178_RS03395	COG3956	TIGRFAM MazG family protein
JN178_RS03430	COG1028	Short-chain dehydrogenase reductase Sdr
JN178_RS03480	COG0642	Histidine kinase
JN178_RS03500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JN178_RS03505	COG0723	plastoquinol--plastocyanin reductase activity
JN178_RS03510	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JN178_RS03515	COG2857	Cytochrome c1
JN178_RS03520	COG0625	glutathione transferase activity
JN178_RS03525	COG2969	positive regulation of protein catabolic process
JN178_RS03540	COG0745	RESPONSE REGULATOR receiver
JN178_RS03545	COG2239	Acts as a magnesium transporter
JN178_RS03550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JN178_RS03570	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
JN178_RS03575	COG1137	ATPase activity
JN178_RS03580	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
JN178_RS03590	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
JN178_RS03605	COG1127	ABC transporter
JN178_RS03610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JN178_RS03615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JN178_RS03620	COG2854	intermembrane phospholipid transfer
JN178_RS03630	COG5007	Belongs to the BolA IbaG family
JN178_RS03640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JN178_RS03645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JN178_RS03655	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JN178_RS03680	COG0583	DNA-binding transcription factor activity
JN178_RS03685	COG0384	phenazine biosynthesis protein PhzF
JN178_RS03690	COG0583	DNA-binding transcription factor activity
JN178_RS03695	COG1917	Cupin 2, conserved barrel domain protein
JN178_RS03695	COG4977	sequence-specific DNA binding
JN178_RS03700	COG2259	Doxx family
JN178_RS03715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JN178_RS03725	COG3220	belongs to the UPF0276 family
JN178_RS03760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JN178_RS03785	COG1162	GTPase activity
JN178_RS03820	COG0745	RESPONSE REGULATOR receiver
JN178_RS03830	COG0697	spore germination
JN178_RS03840	COG0784	Response regulator, receiver
JN178_RS03840	COG2205	protein histidine kinase activity
JN178_RS03870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JN178_RS03880	COG0126	phosphoglycerate kinase activity
JN178_RS03885	COG3588	fructose-bisphosphate aldolase
JN178_RS03905	COG0248	Ppx GppA phosphatase
JN178_RS03910	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JN178_RS03920	COG0573	inorganic phosphate transmembrane transporter activity
JN178_RS03930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JN178_RS03940	COG0306	phosphate transporter
JN178_RS03950	COG0583	DNA-binding transcription factor activity
JN178_RS03975	COG1272	protein, Hemolysin III
JN178_RS03980	COG1846	Transcriptional regulator
JN178_RS03985	COG1764	response to oxidative stress
JN178_RS04005	COG1739	Uncharacterized protein family UPF0029
JN178_RS04020	COG0420	3'-5' exonuclease activity
JN178_RS04025	COG0419	ATPase involved in DNA repair
JN178_RS04040	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
JN178_RS04045	COG0010	Belongs to the arginase family
JN178_RS04055	COG2188	Transcriptional regulator
JN178_RS04060	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JN178_RS04065	COG2986	histidine ammonia-lyase
JN178_RS04085	COG2971	BadF BadG BcrA BcrD
JN178_RS04090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JN178_RS04100	COG0488	(ABC) transporter
JN178_RS04105	COG3002	Belongs to the UPF0753 family
JN178_RS04110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JN178_RS04115	COG0009	L-threonylcarbamoyladenylate synthase
JN178_RS04120	COG0583	DNA-binding transcription factor activity
JN178_RS04140	COG0668	transmembrane transport
JN178_RS04155	COG2249	NAD(P)H dehydrogenase (quinone) activity
JN178_RS04160	COG0583	DNA-binding transcription factor activity
JN178_RS04180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JN178_RS04205	COG1858	cytochrome C peroxidase
JN178_RS04235	COG1346	cytolysis
JN178_RS04270	COG0583	DNA-binding transcription factor activity
JN178_RS04275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JN178_RS04285	COG0513	Belongs to the DEAD box helicase family
JN178_RS04300	COG3655	Transcriptional regulator
JN178_RS04315	COG3409	Peptidoglycan-binding domain 1 protein
JN178_RS04315	COG3267	Type II secretory pathway component ExeA
JN178_RS04330	COG0066	3-isopropylmalate dehydratase activity
JN178_RS04340	COG0473	3-isopropylmalate dehydrogenase activity
JN178_RS04345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JN178_RS04380	COG2271	Major facilitator Superfamily
JN178_RS04390	COG0800	Aldolase
JN178_RS04395	COG2186	Transcriptional regulator
JN178_RS04430	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JN178_RS04445	COG4555	ABC transporter
JN178_RS04450	COG1668	transmembrane transport
JN178_RS04460	COG0745	RESPONSE REGULATOR receiver
JN178_RS04495	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JN178_RS04500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JN178_RS04505	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JN178_RS04515	COG1138	Cytochrome C-type biogenesis protein
JN178_RS04535	COG2853	Lipoprotein
JN178_RS04545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JN178_RS04585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JN178_RS04600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JN178_RS04605	COG1555	photosystem II stabilization
JN178_RS04610	COG0473	3-isopropylmalate dehydrogenase activity
JN178_RS04625	COG1611	Belongs to the LOG family
JN178_RS04675	COG0564	pseudouridine synthase activity
JN178_RS04690	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JN178_RS04695	COG0024	Methionine aminopeptidase
JN178_RS04700	COG0052	Belongs to the universal ribosomal protein uS2 family
JN178_RS04710	COG0528	UMP kinase activity
JN178_RS04720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JN178_RS04725	COG0575	Belongs to the CDS family
JN178_RS04730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JN178_RS04735	COG0750	zinc metalloprotease
JN178_RS04750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JN178_RS04770	COG0587	DNA-directed DNA polymerase activity
JN178_RS04775	COG0825	malonyl-CoA metabolic process
JN178_RS04780	COG0037	tRNA processing
JN178_RS04785	COG3706	GGDEF domain
JN178_RS04810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JN178_RS04810	COG0047	phosphoribosylformylglycinamidine synthase activity
JN178_RS04820	COG2840	Smr protein MutS2
JN178_RS04875	COG0835	chemotaxis
JN178_RS04875	COG0784	Response regulator, receiver
JN178_RS04880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JN178_RS04885	COG1815	bacterial-type flagellum-dependent cell motility
JN178_RS04895	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
JN178_RS04900	COG1749	Flagellar hook protein flgE
JN178_RS04905	COG4787	bacterial-type flagellum-dependent cell motility
JN178_RS04925	COG3951	Flagellar rod assembly protein muramidase FlgJ
JN178_RS04925	COG1705	Flagellar rod assembly protein muramidase FlgJ
JN178_RS04930	COG1256	bacterial-type flagellum assembly
JN178_RS04955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JN178_RS04965	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JN178_RS05000	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JN178_RS05005	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JN178_RS05025	COG1215	transferase activity, transferring glycosyl groups
JN178_RS05030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JN178_RS05035	COG1086	Polysaccharide biosynthesis protein
JN178_RS05050	COG3475	LICD family
JN178_RS05055	COG2089	acid synthase
JN178_RS05065	COG1083	cytidylyl-transferase
JN178_RS05070	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JN178_RS05095	COG1677	Flagellar hook-basal body complex protein FliE
JN178_RS05100	COG1766	The M ring may be actively involved in energy transduction
JN178_RS05105	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JN178_RS05155	COG1987	bacterial-type flagellum assembly
JN178_RS05170	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JN178_RS05195	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
JN178_RS05200	COG0784	Response regulator, receiver
JN178_RS05200	COG0643	Histidine kinase
JN178_RS05200	COG2198	Histidine kinase
JN178_RS05205	COG2201	protein-glutamate methylesterase activity
JN178_RS05210	COG1192	Involved in chromosome partitioning
JN178_RS05220	COG0835	chemotaxis
JN178_RS05235	COG0646	methionine synthase
JN178_RS05235	COG1410	methionine synthase
JN178_RS05240	COG0646	methionine synthase
JN178_RS05240	COG1410	methionine synthase
JN178_RS05250	COG4269	membrane
JN178_RS05265	COG0583	DNA-binding transcription factor activity
JN178_RS05280	COG0659	secondary active sulfate transmembrane transporter activity
JN178_RS05290	COG1309	transcriptional regulator
JN178_RS05295	COG3590	peptidase
JN178_RS05310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JN178_RS05345	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
JN178_RS05350	COG4172	Belongs to the ABC transporter superfamily
JN178_RS05360	COG4171	peptide transport system, permease
JN178_RS05365	COG4168	peptide transport system, permease
JN178_RS05370	COG0747	negative chemotaxis
JN178_RS05375	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JN178_RS05380	COG1842	Phage shock protein A
JN178_RS05410	COG0625	glutathione transferase activity
JN178_RS05415	COG1522	sequence-specific DNA binding
JN178_RS05465	COG0811	peptide transport
JN178_RS05470	COG0811	peptide transport
JN178_RS05475	COG0848	biopolymer transport protein
JN178_RS05530	COG0456	acetyltransferase
JN178_RS05540	COG0583	DNA-binding transcription factor activity
JN178_RS05545	COG2814	Major facilitator Superfamily
JN178_RS05550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN178_RS05555	COG0656	L-ascorbic acid biosynthetic process
JN178_RS05565	COG3706	GGDEF domain
JN178_RS05585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JN178_RS05590	COG3706	GGDEF domain
JN178_RS05605	COG0583	DNA-binding transcription factor activity
JN178_RS05610	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JN178_RS05625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JN178_RS05650	COG0583	DNA-binding transcription factor activity
JN178_RS05655	COG0702	epimerase
JN178_RS05690	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JN178_RS05695	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JN178_RS05700	COG0564	pseudouridine synthase activity
JN178_RS05710	COG0612	Peptidase, M16
JN178_RS05715	COG2918	glutathione biosynthetic process
JN178_RS05725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JN178_RS05730	COG0784	Response regulator, receiver
JN178_RS05730	COG5002	protein histidine kinase activity
JN178_RS05740	COG1136	(ABC) transporter
JN178_RS05745	COG0577	efflux transmembrane transporter activity
JN178_RS05745	COG1136	(ABC) transporter
JN178_RS05750	COG0577	efflux transmembrane transporter activity
JN178_RS05750	COG1136	(ABC) transporter
JN178_RS05765	COG0366	Alpha amylase catalytic
JN178_RS05780	COG2840	Smr protein MutS2
JN178_RS05785	COG2890	protein-(glutamine-N5) methyltransferase activity
JN178_RS05800	COG2719	SpoVR family
JN178_RS05805	COG2718	Belongs to the UPF0229 family
JN178_RS05810	COG2766	serine protein kinase
JN178_RS05815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JN178_RS05820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JN178_RS05825	COG4771	TonB-dependent receptor
JN178_RS05840	COG4206	TonB-dependent receptor
JN178_RS05850	COG0450	alkyl hydroperoxide reductase
JN178_RS05865	COG0584	glycerophosphoryl diester phosphodiesterase
JN178_RS05870	COG0346	lactoylglutathione lyase activity
JN178_RS05875	COG1028	Short-chain dehydrogenase reductase Sdr
JN178_RS05880	COG1278	Cold shock
JN178_RS05895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JN178_RS05900	COG4660	Part of a membrane complex involved in electron transport
JN178_RS05905	COG4659	FMN binding
JN178_RS05910	COG4658	electron transport chain
JN178_RS05915	COG4656	Part of a membrane complex involved in electron transport
JN178_RS05920	COG2878	Part of a membrane complex involved in electron transport
JN178_RS05925	COG4657	Part of a membrane complex involved in electron transport
JN178_RS05940	COG0534	Mate efflux family protein
JN178_RS05945	COG0556	nucleotide-excision repair
JN178_RS05970	COG0602	queuosine metabolic process
JN178_RS05980	COG0367	asparagine synthase
JN178_RS06005	COG0471	metal ion transport
JN178_RS06005	COG3273	potassium ion transport
JN178_RS06020	COG0529	Catalyzes the synthesis of activated sulfate
JN178_RS06025	COG0175	sulfate reduction
JN178_RS06030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JN178_RS06060	COG2304	oxidoreductase activity
JN178_RS06080	COG0714	Associated with various cellular activities
JN178_RS06090	COG1250	3-hydroxyacyl-CoA dehydrogenase
JN178_RS06090	COG1024	Enoyl-CoA hydratase
JN178_RS06110	COG1025	Belongs to the peptidase M16 family
JN178_RS06115	COG2062	phosphohistidine phosphatase, SixA
JN178_RS06125	COG4536	flavin adenine dinucleotide binding
JN178_RS06130	COG4137	Cytochrome C assembly protein
JN178_RS06135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JN178_RS06175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JN178_RS06180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JN178_RS06185	COG1132	(ABC) transporter
JN178_RS06190	COG0228	four-way junction DNA binding
JN178_RS06195	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JN178_RS06200	COG0336	Belongs to the RNA methyltransferase TrmD family
JN178_RS06205	COG0335	large ribosomal subunit rRNA binding
JN178_RS06210	COG2860	membrane
JN178_RS06225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JN178_RS06230	COG1605	Chorismate mutase
JN178_RS06230	COG0287	Prephenate dehydrogenase
JN178_RS06240	COG0077	Prephenate dehydratase
JN178_RS06240	COG1605	Chorismate mutase
JN178_RS06245	COG0745	RESPONSE REGULATOR receiver
JN178_RS06250	COG0023	Translation Initiation Factor
JN178_RS06280	COG2205	protein histidine kinase activity
JN178_RS06290	COG2204	response regulator
JN178_RS06300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JN178_RS06305	COG0494	nUDIX hydrolase
JN178_RS06310	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JN178_RS06315	COG0632	four-way junction helicase activity
JN178_RS06320	COG2255	four-way junction helicase activity
JN178_RS06325	COG0824	Thioesterase
JN178_RS06330	COG0811	peptide transport
JN178_RS06345	COG0823	Involved in the tonB-independent uptake of proteins
JN178_RS06350	COG2885	chlorophyll binding
JN178_RS06355	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
JN178_RS06380	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JN178_RS06405	COG4319	ketosteroid isomerase
JN178_RS06425	COG1725	Transcriptional regulator
JN178_RS06485	COG3620	sequence-specific DNA binding
JN178_RS06490	COG4667	esterase of the alpha-beta hydrolase superfamily
JN178_RS06500	COG0513	Belongs to the DEAD box helicase family
JN178_RS06520	COG0583	DNA-binding transcription factor activity
JN178_RS06530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JN178_RS06540	COG1309	transcriptional regulator
JN178_RS06545	COG4774	siderophore transport
JN178_RS06565	COG3706	GGDEF domain
JN178_RS06575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JN178_RS06575	COG3008	intermembrane lipid transfer
JN178_RS06580	COG2995	paraquat-inducible protein a
JN178_RS06590	COG0583	DNA-binding transcription factor activity
JN178_RS06610	COG2207	Transcriptional regulator
JN178_RS06615	COG0017	Asparaginyl-tRNA synthetase
JN178_RS06630	COG0189	ligase activity
JN178_RS06650	COG2201	protein-glutamate methylesterase activity
JN178_RS06655	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
JN178_RS06685	COG0156	8-amino-7-oxononanoate synthase activity
JN178_RS06700	COG3340	Belongs to the peptidase S51 family
JN178_RS06705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JN178_RS06710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JN178_RS06715	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
JN178_RS06720	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
JN178_RS06750	COG2205	protein histidine kinase activity
JN178_RS06755	COG0745	RESPONSE REGULATOR receiver
JN178_RS06760	COG0569	domain protein
JN178_RS06765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JN178_RS06775	COG5265	(ABC) transporter
JN178_RS06780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JN178_RS06790	COG0745	RESPONSE REGULATOR receiver
JN178_RS06815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JN178_RS06860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JN178_RS06865	COG0402	S-adenosylhomocysteine deaminase activity
JN178_RS06870	COG0402	S-adenosylhomocysteine deaminase activity
JN178_RS06885	COG2755	lipolytic protein G-D-S-L family
JN178_RS06890	COG4181	ATPase activity
JN178_RS06895	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
JN178_RS06900	COG1090	epimerase
JN178_RS06905	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JN178_RS06910	COG0628	permease
JN178_RS06930	COG2350	Protein conserved in bacteria
JN178_RS06935	COG0159	tryptophan synthase activity
JN178_RS06945	COG0135	phosphoribosylanthranilate isomerase activity
JN178_RS06945	COG0134	indole-3-glycerol-phosphate synthase activity
JN178_RS06950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JN178_RS06960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JN178_RS06965	COG0613	PHP domain protein
JN178_RS06970	COG0009	L-threonylcarbamoyladenylate synthase
JN178_RS06980	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JN178_RS06995	COG0656	L-ascorbic acid biosynthetic process
JN178_RS07000	COG2188	Transcriptional regulator
JN178_RS07005	COG1131	(ABC) transporter
JN178_RS07015	COG1506	peptidase
JN178_RS07015	COG0823	Involved in the tonB-independent uptake of proteins
JN178_RS07020	COG0110	maltose O-acetyltransferase activity
JN178_RS07030	COG2733	membrane
JN178_RS07050	COG0500	methyltransferase
JN178_RS07055	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JN178_RS07060	COG0497	DNA recombination
JN178_RS07065	COG0783	Belongs to the Dps family
JN178_RS07070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JN178_RS07080	COG1454	alcohol dehydrogenase
JN178_RS07085	COG1028	Short-chain dehydrogenase reductase Sdr
JN178_RS07095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JN178_RS07100	COG2610	gluconate transmembrane transporter activity
JN178_RS07115	COG0784	Response regulator, receiver
JN178_RS07115	COG2205	protein histidine kinase activity
JN178_RS07120	COG2199	diguanylate cyclase activity
JN178_RS07125	COG0784	Response regulator, receiver
JN178_RS07125	COG2205	protein histidine kinase activity
JN178_RS07130	COG1620	l-lactate permease
JN178_RS07135	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JN178_RS07145	COG0484	heat shock protein binding
JN178_RS07150	COG3909	cytochrome
JN178_RS07160	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JN178_RS07185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JN178_RS07195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JN178_RS07200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JN178_RS07205	COG0840	transmembrane signaling receptor activity
JN178_RS07235	COG0280	phosphate acetyltransferase
JN178_RS07235	COG0857	belongs to the CobB CobQ family
JN178_RS07240	COG1228	amidohydrolase
JN178_RS07245	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JN178_RS07250	COG4535	Mg2 and Co2 transporter CorC
JN178_RS07260	COG1702	phosphate starvation-inducible protein PhoH
JN178_RS07270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JN178_RS07280	COG3706	GGDEF domain
JN178_RS07285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JN178_RS07290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JN178_RS07335	COG1607	acyl-coa hydrolase
JN178_RS07340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JN178_RS07345	COG1733	regulation of RNA biosynthetic process
JN178_RS07350	COG1028	Short-chain dehydrogenase reductase Sdr
JN178_RS07360	COG1115	amino acid carrier protein
JN178_RS07410	COG0012	GTP binding
JN178_RS07435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JN178_RS07445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JN178_RS07450	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
JN178_RS07455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JN178_RS07465	COG2890	protein-(glutamine-N5) methyltransferase activity
JN178_RS07470	COG0784	Response regulator, receiver
JN178_RS07470	COG3437	response regulator, receiver
JN178_RS07480	COG2877	3-deoxy-8-phosphooctulonate synthase activity
JN178_RS07490	COG0583	DNA-binding transcription factor activity
JN178_RS07500	COG2363	Small membrane protein
JN178_RS07520	COG3409	Peptidoglycan-binding domain 1 protein
JN178_RS07520	COG0793	Belongs to the peptidase S41A family
JN178_RS07525	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
JN178_RS07535	COG2116	formate transmembrane transporter activity
JN178_RS07550	COG0714	Associated with various cellular activities
JN178_RS07555	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
JN178_RS07560	COG0033	Phosphoglucomutase
JN178_RS07565	COG0058	SHG alpha-glucan phosphorylase activity
JN178_RS07570	COG5001	Diguanylate cyclase
JN178_RS07570	COG3300	MHYT domain
JN178_RS07575	COG2988	succinylglutamate desuccinylase activity
JN178_RS07595	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
JN178_RS07615	COG1393	Belongs to the ArsC family
JN178_RS07640	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
JN178_RS07660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JN178_RS07675	COG3268	Saccharopine dehydrogenase
JN178_RS07685	COG5001	Diguanylate cyclase
JN178_RS07685	COG3300	MHYT domain
JN178_RS07695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JN178_RS07705	COG1309	transcriptional regulator
JN178_RS07755	COG2249	NAD(P)H dehydrogenase (quinone) activity
JN178_RS07780	COG1733	regulation of RNA biosynthetic process
JN178_RS07790	COG2249	NAD(P)H dehydrogenase (quinone) activity
JN178_RS07795	COG3706	GGDEF domain
JN178_RS07805	COG0402	S-adenosylhomocysteine deaminase activity
JN178_RS07810	COG2351	hydroxyisourate hydrolase activity
JN178_RS07825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JN178_RS07835	COG1309	transcriptional regulator
JN178_RS07850	COG2252	PERMEase
JN178_RS07855	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JN178_RS07875	COG2205	protein histidine kinase activity
JN178_RS07875	COG0784	Response regulator, receiver
JN178_RS07890	COG2233	PERMEase
JN178_RS07905	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JN178_RS07910	COG0730	response to heat
JN178_RS07920	COG0154	amidase activity
JN178_RS07950	COG1028	Short-chain dehydrogenase reductase Sdr
JN178_RS07955	COG3001	Fructosamine kinase
JN178_RS07965	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JN178_RS07985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JN178_RS07995	COG1596	polysaccharide export
JN178_RS08000	COG0489	protein tyrosine kinase activity
JN178_RS08005	COG4464	protein tyrosine phosphatase activity
JN178_RS08030	COG5001	Diguanylate cyclase
JN178_RS08085	COG0463	Glycosyl transferase, family 2
JN178_RS08100	COG0072	phenylalanine-tRNA ligase activity
JN178_RS08100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JN178_RS08130	COG1472	Belongs to the glycosyl hydrolase 3 family
JN178_RS08140	COG2096	Adenosyltransferase
JN178_RS08150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JN178_RS08160	COG4591	ABC-type transport system involved in lipoprotein release permease component
JN178_RS08165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JN178_RS08185	COG0708	Exodeoxyribonuclease III
JN178_RS08245	COG2814	Major facilitator Superfamily
JN178_RS08280	COG4770	biotin carboxylase activity
JN178_RS08290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JN178_RS08295	COG1960	acyl-CoA dehydrogenase activity
JN178_RS08300	COG0789	Transcriptional regulator
JN178_RS08305	COG0183	Belongs to the thiolase family
JN178_RS08330	COG2925	Exonuclease
JN178_RS08355	COG1643	Atp-dependent helicase
JN178_RS08375	COG3321	synthase
JN178_RS08375	COG0604	alcohol dehydrogenase
JN178_RS08380	COG0328	RNA-DNA hybrid ribonuclease activity
JN178_RS08385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JN178_RS08415	COG1136	(ABC) transporter
JN178_RS08420	COG4591	ABC-type transport system involved in lipoprotein release permease component
JN178_RS08425	COG1301	dicarboxylic acid transport
JN178_RS08435	COG3724	N-succinylarginine dihydrolase activity
JN178_RS08440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JN178_RS08445	COG3122	Protein conserved in bacteria
JN178_RS08460	COG1609	Transcriptional regulator
JN178_RS08480	COG0800	Aldolase
JN178_RS08485	COG2271	Major facilitator Superfamily
JN178_RS08490	COG4948	Mandelate Racemase Muconate Lactonizing
JN178_RS08500	COG5285	phytanoyl-CoA dioxygenase
JN178_RS08580	COG2124	cytochrome p450
JN178_RS08600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
JN178_RS08605	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
JN178_RS08610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
JN178_RS08615	COG1012	belongs to the aldehyde dehydrogenase family
JN178_RS08620	COG1028	Short-chain dehydrogenase reductase Sdr
JN178_RS08625	COG1063	alcohol dehydrogenase
JN178_RS08630	COG4948	Mandelate Racemase Muconate Lactonizing
JN178_RS08640	COG3386	PFAM SMP-30 Gluconolaconase
JN178_RS08645	COG2814	Major facilitator Superfamily
JN178_RS08650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JN178_RS08665	COG0625	glutathione transferase activity
JN178_RS08680	COG0826	peptidase U32
JN178_RS08685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JN178_RS08690	COG2153	protein acetylation
JN178_RS08720	COG5002	protein histidine kinase activity
JN178_RS08750	COG1399	metal-binding, possibly nucleic acid-binding protein
JN178_RS08760	COG0416	fatty acid biosynthetic process
JN178_RS08765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JN178_RS08770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JN178_RS08780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JN178_RS08785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JN178_RS08795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JN178_RS08810	COG0084	hydrolase, TatD family'
JN178_RS08815	COG0259	pyridoxamine-phosphate oxidase activity
JN178_RS08820	COG0702	epimerase
JN178_RS08845	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JN178_RS08850	COG1609	Transcriptional regulator
JN178_RS08880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JN178_RS08890	COG4771	TonB-dependent receptor
JN178_RS08925	COG3012	SEC-C Motif Domain Protein
JN178_RS08935	COG1238	metal cluster binding
JN178_RS08955	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JN178_RS08960	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
JN178_RS08965	COG0436	Aminotransferase
JN178_RS08980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JN178_RS08990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JN178_RS08995	COG1765	OsmC-like protein
JN178_RS09000	COG2996	Protein conserved in bacteria
JN178_RS09010	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JN178_RS09015	COG1984	allophanate hydrolase subunit 2
JN178_RS09025	COG0735	belongs to the Fur family
JN178_RS09035	COG0716	FMN binding
JN178_RS09045	COG0596	Alpha beta hydrolase
JN178_RS09100	COG1960	acyl-CoA dehydrogenase activity
JN178_RS09105	COG1028	Short-chain dehydrogenase reductase Sdr
JN178_RS09110	COG1028	Short-chain dehydrogenase reductase Sdr
JN178_RS09115	COG1671	Belongs to the UPF0178 family
JN178_RS09125	COG0840	transmembrane signaling receptor activity
JN178_RS09135	COG1448	Aminotransferase
JN178_RS09180	COG1024	Enoyl-CoA hydratase
JN178_RS09185	COG0405	Gamma-glutamyltransferase
JN178_RS09330	COG3547	Transposase (IS116 IS110 IS902 family)
JN178_RS09350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JN178_RS09370	COG0534	Mate efflux family protein
JN178_RS09375	COG0303	'Molybdopterin
JN178_RS09385	COG0366	Alpha amylase catalytic
JN178_RS09390	COG1215	transferase activity, transferring glycosyl groups
JN178_RS09395	COG3769	mannosylglycerate metabolic process
JN178_RS09400	COG0572	uridine kinase
JN178_RS09430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JN178_RS09465	COG1393	Belongs to the ArsC family
JN178_RS09475	COG4783	chaperone-mediated protein folding
JN178_RS09485	COG0583	DNA-binding transcription factor activity
JN178_RS09500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JN178_RS09510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JN178_RS09515	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
JN178_RS09545	COG3239	Fatty acid desaturase
JN178_RS09555	COG1028	Short-chain dehydrogenase reductase Sdr
JN178_RS09560	COG0583	DNA-binding transcription factor activity
JN178_RS09570	COG0633	Ferredoxin
JN178_RS09575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JN178_RS09580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JN178_RS09585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JN178_RS09595	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JN178_RS09600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JN178_RS09605	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JN178_RS09610	COG0539	negative regulation of cytoplasmic translation
JN178_RS09615	COG0776	regulation of translation
JN178_RS09625	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
JN178_RS09630	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
JN178_RS09635	COG0284	orotidine-5'-phosphate decarboxylase activity
JN178_RS09640	COG0686	Belongs to the AlaDH PNT family
JN178_RS09650	COG0531	amino acid
JN178_RS09650	COG1674	ftsk spoiiie
JN178_RS09655	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JN178_RS09660	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JN178_RS09705	COG2920	part of a sulfur-relay system
JN178_RS09720	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JN178_RS09725	COG0670	Belongs to the BI1 family
JN178_RS09750	COG0583	DNA-binding transcription factor activity
JN178_RS09755	COG2259	Doxx family
JN178_RS09760	COG3384	dioxygenase
JN178_RS09775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
JN178_RS09785	COG1741	Belongs to the pirin family
JN178_RS09790	COG2197	response regulator
JN178_RS09795	COG0322	excinuclease ABC activity
JN178_RS09830	COG4943	cyclic-guanylate-specific phosphodiesterase activity
JN178_RS09835	COG3148	PFAM DTW domain containing protein
JN178_RS09840	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JN178_RS09845	COG2897	thiosulfate sulfurtransferase activity
JN178_RS09855	COG1280	lysine exporter protein (LysE YggA)
JN178_RS09875	COG1752	Esterase of the alpha-beta hydrolase superfamily
JN178_RS09880	COG0037	tRNA processing
JN178_RS09885	COG0589	response to stress
JN178_RS09905	COG2217	Heavy metal translocating P-type atpase
JN178_RS09915	COG2010	Cytochrome c
JN178_RS09930	COG3278	Belongs to the heme-copper respiratory oxidase family
JN178_RS09940	COG2193	ferroxidase activity
JN178_RS09955	COG0069	glutamate synthase activity
JN178_RS09965	COG0589	response to stress
JN178_RS09970	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JN178_RS09980	COG4974	Belongs to the 'phage' integrase family
JN178_RS10025	COG1082	Xylose isomerase domain protein TIM barrel
JN178_RS10050	COG0534	Mate efflux family protein
JN178_RS10065	COG3046	protein related to deoxyribodipyrimidine photolyase
JN178_RS10070	COG0415	Belongs to the DNA photolyase family
JN178_RS10075	COG0415	Belongs to the DNA photolyase family
JN178_RS10080	COG0415	Belongs to the DNA photolyase family
JN178_RS10090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JN178_RS10095	COG3130	regulation of translation
JN178_RS10105	COG0488	(ABC) transporter
JN178_RS10120	COG0167	dihydroorotate dehydrogenase activity
JN178_RS10125	COG2902	Dehydrogenase
JN178_RS10155	COG0308	aminopeptidase N
JN178_RS10160	COG1757	Na H antiporter
JN178_RS10165	COG0733	neurotransmitter:sodium symporter activity
JN178_RS10170	COG0793	Belongs to the peptidase S41A family
JN178_RS10185	COG1956	GAF domain-containing protein
JN178_RS10195	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JN178_RS10205	COG1946	Acyl-CoA thioesterase
JN178_RS10210	COG0515	serine threonine protein kinase
JN178_RS10215	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JN178_RS10225	COG0022	dehydrogenase e1 component
JN178_RS10230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JN178_RS10235	COG1404	Belongs to the peptidase S8 family
JN178_RS10240	COG1322	Protein conserved in bacteria
JN178_RS10255	COG0494	nUDIX hydrolase
JN178_RS10260	COG1760	l-serine dehydratase
JN178_RS10285	COG0583	DNA-binding transcription factor activity
JN178_RS10290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JN178_RS10295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JN178_RS10300	COG0513	Belongs to the DEAD box helicase family
JN178_RS10310	COG1054	Belongs to the UPF0176 family
JN178_RS10320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN178_RS10320	COG2205	protein histidine kinase activity
JN178_RS10325	COG2207	Transcriptional regulator
JN178_RS10330	COG1073	alpha beta
JN178_RS10340	COG0205	6-phosphofructokinase activity
JN178_RS10350	COG3279	Response regulator of the LytR AlgR family
JN178_RS10355	COG3275	phosphorelay sensor kinase activity
JN178_RS10385	COG3081	Nucleoid-associated protein
JN178_RS10390	COG3082	Protein of unknown function (DUF1414)
JN178_RS10395	COG3083	sulfuric ester hydrolase activity
JN178_RS10400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JN178_RS10405	COG2226	methyltransferase
JN178_RS10410	COG1024	Enoyl-CoA hydratase
JN178_RS10415	COG1960	acyl-CoA dehydrogenase activity
JN178_RS10425	COG2084	Dehydrogenase
JN178_RS10430	COG0386	Belongs to the glutathione peroxidase family
JN178_RS10435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JN178_RS10440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JN178_RS10445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JN178_RS10460	COG0616	signal peptide processing
JN178_RS10470	COG2267	carboxylic ester hydrolase activity
JN178_RS10475	COG1028	Short-chain dehydrogenase reductase Sdr
JN178_RS10485	COG1609	Transcriptional regulator
JN178_RS10500	COG0366	Alpha amylase catalytic
JN178_RS10525	COG4667	esterase of the alpha-beta hydrolase superfamily
JN178_RS10580	COG0508	dehydrogenase complex catalyzes the overall conversion of
JN178_RS10585	COG0567	Dehydrogenase, E1 component
JN178_RS10590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JN178_RS10595	COG1053	succinate dehydrogenase
JN178_RS10600	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JN178_RS10610	COG0372	Belongs to the citrate synthase family
JN178_RS10630	COG0435	Glutathione S-transferase
JN178_RS10635	COG0579	oxidoreductase
JN178_RS10640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JN178_RS10680	COG1663	tetraacyldisaccharide 4'-kinase activity
JN178_RS10685	COG1132	(ABC) transporter
JN178_RS10690	COG2333	competence protein COMEC
JN178_RS10690	COG0658	competence protein
JN178_RS10700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JN178_RS10710	COG1196	nuclear chromosome segregation
JN178_RS10715	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
JN178_RS10800	COG2226	methyltransferase
JN178_RS10895	COG1185	polyribonucleotide nucleotidyltransferase activity
JN178_RS10910	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JN178_RS10915	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JN178_RS10920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JN178_RS10935	COG0561	phosphatase activity
JN178_RS10940	COG1028	Short-chain dehydrogenase reductase Sdr
JN178_RS10950	COG1803	Methylglyoxal synthase
JN178_RS10950	COG1597	lipid kinase activity
JN178_RS10955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JN178_RS10975	COG3706	GGDEF domain
JN178_RS10985	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JN178_RS10990	COG0149	triose-phosphate isomerase activity
JN178_RS10995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JN178_RS11000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JN178_RS11005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JN178_RS11010	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JN178_RS11015	COG1534	Rna-binding protein
JN178_RS11030	COG1067	ATP-dependent peptidase activity
JN178_RS11040	COG0495	leucyl-tRNA aminoacylation
JN178_RS11045	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
JN178_RS11050	COG1466	dna polymerase III delta subunit
JN178_RS11055	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JN178_RS11060	COG0799	negative regulation of ribosome biogenesis
JN178_RS11065	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JN178_RS11070	COG0768	penicillin binding
JN178_RS11075	COG0772	Belongs to the SEDS family
JN178_RS11080	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JN178_RS11085	COG1686	Belongs to the peptidase S11 family
JN178_RS11090	COG2921	Belongs to the UPF0250 family
JN178_RS11095	COG0321	lipoyl(octanoyl) transferase activity
JN178_RS11100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JN178_RS11105	COG0252	asparaginase activity
JN178_RS11125	COG0778	Nitroreductase
JN178_RS11140	COG0616	signal peptide processing
JN178_RS11150	COG3092	negative regulation of chromosome organization
JN178_RS11155	COG0492	ferredoxin-NADP+ reductase activity
JN178_RS11160	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JN178_RS11165	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
JN178_RS11170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JN178_RS11175	COG0542	response to heat
JN178_RS11180	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JN178_RS11185	COG1278	Cold shock
JN178_RS11195	COG1187	pseudouridine synthase activity
JN178_RS11200	COG0482	sulfurtransferase activity
JN178_RS11205	COG2915	High frequency lysogenization protein hflD homolog
JN178_RS11210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JN178_RS11220	COG2850	peptidyl-arginine hydroxylation
JN178_RS11255	COG0574	Belongs to the PEP-utilizing enzyme family
JN178_RS11255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JN178_RS11270	COG0457	Tetratricopeptide repeat
JN178_RS11275	COG4771	TonB-dependent receptor
JN178_RS11280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JN178_RS11290	COG2914	Belongs to the UPF0125 (RnfH) family
JN178_RS11295	COG2867	negative regulation of translational initiation
JN178_RS11305	COG1902	pentaerythritol trinitrate reductase activity
JN178_RS11315	COG3706	GGDEF domain
JN178_RS11325	COG1131	(ABC) transporter
JN178_RS11355	COG0583	DNA-binding transcription factor activity
JN178_RS11395	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JN178_RS11400	COG4136	ATPase activity
JN178_RS11405	COG4135	transport system, permease component
JN178_RS11410	COG4134	Bacterial extracellular solute-binding protein
JN178_RS11420	COG4771	TonB-dependent receptor
JN178_RS11435	COG1032	radical SAM domain protein
JN178_RS11505	COG3153	acetyltransferase
JN178_RS11505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JN178_RS11535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JN178_RS11550	COG0195	Participates in both transcription termination and antitermination
JN178_RS11560	COG3437	response regulator, receiver
JN178_RS11565	COG0784	Response regulator, receiver
JN178_RS11565	COG2198	Histidine kinase
JN178_RS11565	COG2205	protein histidine kinase activity
JN178_RS11590	COG2205	protein histidine kinase activity
JN178_RS11595	COG0745	RESPONSE REGULATOR receiver
JN178_RS11615	COG4771	TonB-dependent receptor
JN178_RS11620	COG0668	transmembrane transport
JN178_RS11675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JN178_RS11700	COG0596	Alpha beta hydrolase
JN178_RS11705	COG1960	acyl-CoA dehydrogenase activity
JN178_RS11710	COG0183	Belongs to the thiolase family
JN178_RS11720	COG0596	Alpha beta hydrolase
JN178_RS11725	COG1028	Short-chain dehydrogenase reductase Sdr
JN178_RS11740	COG0366	Alpha amylase catalytic
JN178_RS11745	COG0604	alcohol dehydrogenase
JN178_RS11755	COG1960	acyl-CoA dehydrogenase activity
JN178_RS11765	COG4771	TonB-dependent receptor
JN178_RS11790	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JN178_RS11810	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JN178_RS11815	COG0315	cyclic pyranopterin monophosphate synthase activity
JN178_RS11820	COG0521	Mo-molybdopterin cofactor biosynthetic process
JN178_RS11825	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JN178_RS11845	COG0436	Aminotransferase
JN178_RS11850	COG3268	Saccharopine dehydrogenase
JN178_RS11860	COG1017	nitric oxide dioxygenase activity
JN178_RS11860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JN178_RS11870	COG3604	Transcriptional regulator
JN178_RS11895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JN178_RS11910	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JN178_RS11915	COG1074	ATP-dependent DNA helicase activity
JN178_RS11920	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JN178_RS11930	COG1022	Amp-dependent synthetase and ligase
JN178_RS11935	COG5001	Diguanylate cyclase
JN178_RS11935	COG3300	MHYT domain
JN178_RS11955	COG0583	DNA-binding transcription factor activity
JN178_RS11975	COG0640	Transcriptional regulator
JN178_RS11985	COG0583	DNA-binding transcription factor activity
JN178_RS11990	COG3932	Exopolysaccharide synthesis, ExoD
JN178_RS11995	COG2204	response regulator
JN178_RS12005	COG4251	negative regulation of phosphorylation
JN178_RS12010	COG0784	Response regulator, receiver
JN178_RS12015	COG0784	Response regulator, receiver
JN178_RS12015	COG2205	protein histidine kinase activity
JN178_RS12045	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
JN178_RS12070	COG3139	Protein of unknown function (DUF1315)
JN178_RS12080	COG1115	amino acid carrier protein
JN178_RS12085	COG2866	Carboxypeptidase
JN178_RS12105	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JN178_RS12115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JN178_RS12120	COG1640	4-alpha-glucanotransferase
JN178_RS12130	COG0676	glucose-6-phosphate 1-epimerase activity
JN178_RS12135	COG0800	Aldolase
JN178_RS12145	COG0129	dihydroxy-acid dehydratase activity
JN178_RS12155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JN178_RS12160	COG1737	Transcriptional regulator
JN178_RS12165	COG0469	pyruvate kinase activity
JN178_RS12195	COG0784	Response regulator, receiver
JN178_RS12195	COG2205	protein histidine kinase activity
JN178_RS12210	COG2356	endonuclease I
JN178_RS12240	COG0583	DNA-binding transcription factor activity
JN178_RS12250	COG1979	alcohol dehydrogenase
JN178_RS12255	COG5001	Diguanylate cyclase
JN178_RS12265	COG0753	catalase activity
JN178_RS12270	COG3437	response regulator, receiver
JN178_RS12270	COG0784	Response regulator, receiver
JN178_RS12275	COG4191	Histidine kinase
JN178_RS12275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN178_RS12310	COG0778	Nitroreductase
JN178_RS12330	COG0330	HflC and HflK could
JN178_RS12360	COG0431	NADPH-dependent FMN reductase
JN178_RS12365	COG1741	Belongs to the pirin family
JN178_RS12370	COG0583	DNA-binding transcription factor activity
JN178_RS12390	COG0471	metal ion transport
JN178_RS12405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JN178_RS12405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JN178_RS12410	COG2226	methyltransferase
JN178_RS12415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JN178_RS12420	COG0741	lytic transglycosylase activity
JN178_RS12420	COG1388	LysM domain
JN178_RS12440	COG0215	cysteine-tRNA ligase activity
JN178_RS12445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JN178_RS12450	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JN178_RS12455	COG1785	Belongs to the alkaline phosphatase family
JN178_RS12460	COG1785	Belongs to the alkaline phosphatase family
JN178_RS12475	COG2268	Band 7 protein
JN178_RS12485	COG1136	(ABC) transporter
JN178_RS12505	COG2205	protein histidine kinase activity
JN178_RS12535	COG0604	alcohol dehydrogenase
JN178_RS12540	COG0583	DNA-binding transcription factor activity
JN178_RS12570	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JN178_RS12575	COG1286	toxin biosynthetic process
JN178_RS12580	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
JN178_RS12585	COG0285	dihydrofolate synthase activity
JN178_RS12600	COG0101	tRNA pseudouridine synthase activity
JN178_RS12615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JN178_RS12630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JN178_RS12640	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JN178_RS12640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JN178_RS12660	COG1119	ATPase activity
JN178_RS12665	COG0612	Peptidase, M16
JN178_RS12675	COG2031	fatty acid transporter
JN178_RS12690	COG3101	peptidyl-lysine hydroxylation
JN178_RS12730	COG3119	arylsulfatase activity
JN178_RS12770	COG4948	Mandelate Racemase Muconate Lactonizing
JN178_RS12780	COG3119	arylsulfatase activity
JN178_RS12785	COG3119	arylsulfatase activity
JN178_RS12790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JN178_RS12795	COG0800	Aldolase
JN178_RS12805	COG2814	Major facilitator Superfamily
JN178_RS12810	COG1609	Transcriptional regulator
JN178_RS12815	COG4771	TonB-dependent receptor
JN178_RS12830	COG1902	pentaerythritol trinitrate reductase activity
JN178_RS12830	COG0446	pyridine nucleotide-disulphide oxidoreductase
JN178_RS12855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JN178_RS12865	COG4399	Belongs to the UPF0754 family
JN178_RS12895	COG2186	Transcriptional regulator
JN178_RS12905	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JN178_RS12910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JN178_RS12915	COG2983	Belongs to the UPF0260 family
JN178_RS12920	COG0179	Fumarylacetoacetate (FAA) hydrolase
JN178_RS12935	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
JN178_RS12940	COG0318	PFAM AMP-dependent synthetase and ligase
JN178_RS12945	COG2267	carboxylic ester hydrolase activity
JN178_RS12960	COG1214	PFAM Peptidase M22, glycoprotease
JN178_RS12965	COG1199	ATP-dependent helicase activity
JN178_RS12980	COG0671	phosphoesterase, PA-phosphatase related
JN178_RS13015	COG1192	Involved in chromosome partitioning
JN178_RS13025	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JN178_RS13030	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JN178_RS13035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JN178_RS13040	COG0131	Imidazoleglycerol-phosphate dehydratase
JN178_RS13040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JN178_RS13045	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JN178_RS13065	COG0583	DNA-binding transcription factor activity
JN178_RS13070	COG0612	Peptidase, M16
JN178_RS13075	COG0681	Belongs to the peptidase S26 family
JN178_RS13095	COG0326	Molecular chaperone. Has ATPase activity
JN178_RS13100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JN178_RS13120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JN178_RS13125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JN178_RS13135	COG3220	belongs to the UPF0276 family
JN178_RS13175	COG1183	phosphatidylcholine synthase activity
JN178_RS13190	COG0457	Tetratricopeptide repeat
JN178_RS13195	COG0277	FAD linked oxidase domain protein
JN178_RS13200	COG0542	response to heat
JN178_RS13215	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JN178_RS13225	COG1595	DNA-templated transcription, initiation
JN178_RS13240	COG4221	oxidoreductase activity
JN178_RS13245	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JN178_RS13255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JN178_RS13265	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JN178_RS13275	COG0142	geranyltranstransferase activity
JN178_RS13285	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JN178_RS13290	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JN178_RS13300	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JN178_RS13315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JN178_RS13315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JN178_RS13330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JN178_RS13335	COG0488	(ABC) transporter
JN178_RS13345	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JN178_RS13355	COG0560	Phosphoserine phosphatase
JN178_RS13365	COG0084	hydrolase, TatD family'
JN178_RS13380	COG0571	ribonuclease III activity
JN178_RS13400	COG3026	antisigma factor binding
JN178_RS13410	COG1595	DNA-templated transcription, initiation
JN178_RS13415	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JN178_RS13430	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
JN178_RS13440	COG1047	Peptidyl-prolyl cis-trans
JN178_RS13510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JN178_RS13515	COG1047	Peptidyl-prolyl cis-trans
JN178_RS13525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JN178_RS13530	COG0196	riboflavin kinase activity
JN178_RS13540	COG0268	Binds directly to 16S ribosomal RNA
JN178_RS13555	COG1028	Short-chain dehydrogenase reductase Sdr
JN178_RS13560	COG0385	Bile acid
JN178_RS13595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JN178_RS13600	COG0776	regulation of translation
JN178_RS13605	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JN178_RS13615	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JN178_RS13620	COG0740	serine-type endopeptidase activity
JN178_RS13625	COG0544	peptidyl-prolyl cis-trans isomerase activity
JN178_RS13665	COG1720	tRNA m6t6A37 methyltransferase activity
JN178_RS13675	COG1234	tRNA 3'-trailer cleavage
JN178_RS13685	COG0123	including yeast histone deacetylase and acetoin utilization protein
JN178_RS13695	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
JN178_RS13700	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JN178_RS13715	COG1858	cytochrome C peroxidase
JN178_RS13735	COG0516	GMP reductase activity
JN178_RS13735	COG0517	IMP dehydrogenase activity
JN178_RS13740	COG1570	exodeoxyribonuclease VII activity
JN178_RS13765	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JN178_RS13770	COG2976	Protein conserved in bacteria
JN178_RS13790	COG3063	Type IV pilus biogenesis stability protein PilW
JN178_RS13795	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JN178_RS13805	COG2166	iron-sulfur cluster assembly
JN178_RS13820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JN178_RS13825	COG0719	Fe-S assembly protein
JN178_RS13830	COG0396	ATPase activity
JN178_RS13835	COG0719	Fe-S assembly protein
JN178_RS13840	COG1104	cysteine desulfurase activity
JN178_RS13845	COG1959	2 iron, 2 sulfur cluster binding
JN178_RS13850	COG1045	serine acetyltransferase
JN178_RS13855	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
JN178_RS13860	COG0483	inositol monophosphate 1-phosphatase activity
JN178_RS13875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JN178_RS13880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JN178_RS13885	COG1862	Preprotein translocase
JN178_RS13890	COG0343	queuine tRNA-ribosyltransferase activity
JN178_RS13910	COG1842	Phage shock protein A
JN178_RS13915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JN178_RS13935	COG0754	glutathionylspermidine amidase activity
JN178_RS13950	COG1136	(ABC) transporter
JN178_RS13965	COG2066	Belongs to the glutaminase family
JN178_RS13970	COG1785	Belongs to the alkaline phosphatase family
JN178_RS13975	COG0745	RESPONSE REGULATOR receiver
JN178_RS14060	COG0438	transferase activity, transferring glycosyl groups
JN178_RS14105	COG0297	glycogen (starch) synthase activity
JN178_RS14120	COG0367	asparagine synthase
JN178_RS14150	COG0367	asparagine synthase
JN178_RS14185	COG0489	protein tyrosine kinase activity
JN178_RS14195	COG3267	Type II secretory pathway component ExeA
JN178_RS14195	COG3409	Peptidoglycan-binding domain 1 protein
JN178_RS14200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JN178_RS14200	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JN178_RS14225	COG1560	Kdo2-lipid A biosynthetic process
JN178_RS14240	COG1960	acyl-CoA dehydrogenase activity
JN178_RS14255	COG1435	thymidine kinase activity
JN178_RS14265	COG1609	Transcriptional regulator
JN178_RS14270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JN178_RS14290	COG1082	Xylose isomerase domain protein TIM barrel
JN178_RS14300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JN178_RS14315	COG1982	Orn Lys Arg decarboxylase major
JN178_RS14330	COG1012	belongs to the aldehyde dehydrogenase family
JN178_RS14355	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
JN178_RS14360	COG0789	Transcriptional regulator
JN178_RS14395	COG1960	acyl-CoA dehydrogenase activity
JN178_RS14460	COG4771	TonB-dependent receptor
JN178_RS14475	COG1295	ribonuclease BN
JN178_RS14495	COG3279	Response regulator of the LytR AlgR family
JN178_RS14500	COG2819	hydrolase of the alpha beta superfamily
JN178_RS14510	COG4977	sequence-specific DNA binding
JN178_RS14510	COG1917	Cupin 2, conserved barrel domain protein
JN178_RS14540	COG0545	Peptidyl-prolyl cis-trans isomerase
JN178_RS14640	COG4650	regulator
JN178_RS14660	COG1690	Belongs to the RtcB family
JN178_RS14665	COG0430	RNA-3'-phosphate cyclase activity
JN178_RS14670	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
JN178_RS14675	COG1690	Belongs to the RtcB family
JN178_RS14685	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
JN178_RS14685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JN178_RS14700	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JN178_RS14730	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JN178_RS14730	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JN178_RS14750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JN178_RS14760	COG0738	Major facilitator superfamily
JN178_RS14765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JN178_RS14770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JN178_RS14775	COG2971	BadF BadG BcrA BcrD
JN178_RS14790	COG1609	Transcriptional regulator
JN178_RS14800	COG0583	DNA-binding transcription factor activity
JN178_RS14825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JN178_RS14830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JN178_RS14835	COG0006	proline dipeptidase activity
JN178_RS14850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JN178_RS14860	COG5002	protein histidine kinase activity
JN178_RS14860	COG2198	Histidine kinase
JN178_RS14860	COG0784	Response regulator, receiver
JN178_RS14865	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JN178_RS14875	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JN178_RS14880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JN178_RS14900	COG3313	Fe-S protein
JN178_RS14930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JN178_RS14935	COG0508	dehydrogenase complex catalyzes the overall conversion of
JN178_RS14940	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JN178_RS14960	COG3577	Aspartyl protease
JN178_RS14965	COG0157	Belongs to the NadC ModD family
JN178_RS14970	COG4969	Belongs to the N-Me-Phe pilin family
JN178_RS14975	COG1459	type II secretion system
JN178_RS14980	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
JN178_RS14985	COG0237	dephospho-CoA kinase activity
JN178_RS14990	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
JN178_RS14995	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
JN178_RS15005	COG0446	pyridine nucleotide-disulphide oxidoreductase
JN178_RS15005	COG1902	pentaerythritol trinitrate reductase activity
JN178_RS15010	COG2988	succinylglutamate desuccinylase activity
JN178_RS15015	COG0494	nUDIX hydrolase
JN178_RS15025	COG0739	heme binding
JN178_RS15030	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
JN178_RS15035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JN178_RS15040	COG0849	cell division
JN178_RS15045	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JN178_RS15050	COG1181	Belongs to the D-alanine--D-alanine ligase family
JN178_RS15055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JN178_RS15065	COG0772	Belongs to the SEDS family
JN178_RS15070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JN178_RS15080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JN178_RS15085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JN178_RS15090	COG0768	penicillin binding
JN178_RS15095	COG3116	cell division
JN178_RS15105	COG2001	Belongs to the MraZ family
JN178_RS15125	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JN178_RS15150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JN178_RS15150	COG0678	peroxiredoxin activity
JN178_RS15175	COG2204	response regulator
JN178_RS15205	COG0668	transmembrane transport
JN178_RS15210	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JN178_RS15215	COG0189	ligase activity
JN178_RS15220	COG1678	Uncharacterized ACR, COG1678
JN178_RS15225	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JN178_RS15250	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JN178_RS15255	COG0762	integral membrane protein
JN178_RS15285	COG0446	pyridine nucleotide-disulphide oxidoreductase
JN178_RS15285	COG1902	pentaerythritol trinitrate reductase activity
JN178_RS15305	COG0625	glutathione transferase activity
JN178_RS15315	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JN178_RS15330	COG2378	regulation of single-species biofilm formation
JN178_RS15355	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JN178_RS15365	COG0083	homoserine kinase activity
JN178_RS15375	COG0583	DNA-binding transcription factor activity
JN178_RS15385	COG2197	response regulator
JN178_RS15390	COG4585	Histidine kinase
JN178_RS15405	COG0840	transmembrane signaling receptor activity
JN178_RS15410	COG0640	Transcriptional regulator
JN178_RS15420	COG0431	NADPH-dependent FMN reductase
JN178_RS15425	COG0798	PFAM Bile acid sodium symporter
JN178_RS15430	COG2197	response regulator
JN178_RS15435	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
JN178_RS15445	COG5002	protein histidine kinase activity
JN178_RS15445	COG3850	Histidine kinase
JN178_RS15470	COG1748	Saccharopine dehydrogenase
JN178_RS15480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JN178_RS15485	COG3107	peptidoglycan biosynthetic process
JN178_RS15500	COG2823	Periplasmic or secreted lipoprotein
JN178_RS15520	COG4585	Histidine kinase
JN178_RS15525	COG2197	response regulator
JN178_RS15545	COG1802	Transcriptional regulator
JN178_RS15550	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
JN178_RS15555	COG0372	Belongs to the citrate synthase family
JN178_RS15560	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JN178_RS15565	COG2828	Protein conserved in bacteria
JN178_RS15570	COG2199	diguanylate cyclase activity
JN178_RS15570	COG2203	Gaf domain
JN178_RS15585	COG0784	Response regulator, receiver
JN178_RS15585	COG5002	protein histidine kinase activity
JN178_RS15585	COG2198	Histidine kinase
JN178_RS15590	COG3023	N-Acetylmuramoyl-L-alanine amidase
JN178_RS15595	COG0070	glutamate synthase
JN178_RS15595	COG0067	glutamate synthase
JN178_RS15595	COG0069	glutamate synthase activity
JN178_RS15600	COG0493	'glutamate synthase
JN178_RS15605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JN178_RS15625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JN178_RS15630	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
JN178_RS15635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JN178_RS15640	COG1054	Belongs to the UPF0176 family
JN178_RS15655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JN178_RS15660	COG5507	3-demethylubiquinone-9 3-methyltransferase
JN178_RS15665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JN178_RS15670	COG1196	nuclear chromosome segregation
JN178_RS15670	COG0739	heme binding
JN178_RS15670	COG0741	lytic transglycosylase activity
JN178_RS15675	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JN178_RS15700	COG0625	glutathione transferase activity
JN178_RS15720	COG2326	polyphosphate kinase activity
JN178_RS15735	COG1215	transferase activity, transferring glycosyl groups
JN178_RS15750	COG2204	response regulator
JN178_RS15765	COG2894	cell division
JN178_RS15770	COG0850	regulation of cytokinetic process
JN178_RS15790	COG1981	membrane
JN178_RS15805	COG1914	H( )-stimulated, divalent metal cation uptake system
JN178_RS15820	COG1217	gtp-binding protein TYPA
JN178_RS15825	COG0174	glutamine synthetase
JN178_RS15835	COG3852	Histidine kinase
JN178_RS15850	COG3437	response regulator, receiver
JN178_RS15885	COG0525	valine-tRNA ligase activity
JN178_RS15890	COG2927	DNA polymerase III (CHI subunit)
JN178_RS15895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JN178_RS15900	COG0795	lipopolysaccharide-transporting ATPase activity
JN178_RS15905	COG0795	lipopolysaccharide-transporting ATPase activity
JN178_RS15915	COG0673	inositol 2-dehydrogenase activity
JN178_RS16005	COG0464	growth
JN178_RS16050	COG3341	Caulimovirus viroplasmin
JN178_RS16050	COG0328	RNA-DNA hybrid ribonuclease activity
JN178_RS16065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JN178_RS16090	COG0210	DNA helicase
JN178_RS16205	COG0745	RESPONSE REGULATOR receiver
JN178_RS16225	COG1024	Enoyl-CoA hydratase
JN178_RS16250	COG1215	transferase activity, transferring glycosyl groups
JN178_RS16255	COG0438	transferase activity, transferring glycosyl groups
JN178_RS16325	COG0277	FAD linked oxidase domain protein
JN178_RS16380	COG0513	Belongs to the DEAD box helicase family
JN178_RS16405	COG2200	EAL domain
JN178_RS16405	COG2202	Pas domain
JN178_RS16405	COG2199	diguanylate cyclase activity
JN178_RS16415	COG3568	Endonuclease Exonuclease Phosphatase
JN178_RS16430	COG0730	response to heat
JN178_RS16435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JN178_RS16450	COG4191	Histidine kinase
JN178_RS16450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN178_RS16460	COG0417	DNA replication proofreading
JN178_RS16530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JN178_RS16540	COG1573	uracil-dna glycosylase
JN178_RS16545	COG5001	Diguanylate cyclase
JN178_RS16545	COG3300	MHYT domain
JN178_RS16565	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JN178_RS16585	COG1983	PspC domain protein
JN178_RS16590	COG1842	Phage shock protein A
JN178_RS16605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JN178_RS16620	COG0542	response to heat
JN178_RS16635	COG0204	Acyl-transferase
JN178_RS16640	COG0204	Acyl-transferase
JN178_RS16645	COG0668	transmembrane transport
JN178_RS16660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JN178_RS16665	COG0733	neurotransmitter:sodium symporter activity
JN178_RS16680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JN178_RS16705	COG0848	biopolymer transport protein
JN178_RS16715	COG0457	Tetratricopeptide repeat
JN178_RS16720	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
JN178_RS16745	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JN178_RS16750	COG0702	epimerase
JN178_RS16770	COG5002	protein histidine kinase activity
JN178_RS16770	COG5001	Diguanylate cyclase
JN178_RS16780	COG1574	metal-dependent hydrolase with the TIM-barrel fold
JN178_RS16790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JN178_RS16800	COG0583	DNA-binding transcription factor activity
JN178_RS16805	COG0121	glutamine amidotransferase
JN178_RS16835	COG4628	conserved protein (DUF2132)
JN178_RS16840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JN178_RS16850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JN178_RS16860	COG1477	protein flavinylation
JN178_RS16865	COG2871	sodium ion transport
JN178_RS16870	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JN178_RS16875	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JN178_RS16880	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JN178_RS16885	COG1805	sodium ion transport
JN178_RS16890	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JN178_RS16895	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JN178_RS16900	COG0545	Peptidyl-prolyl cis-trans isomerase
JN178_RS16905	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JN178_RS16920	COG0039	L-malate dehydrogenase activity
JN178_RS16925	COG1438	arginine binding
JN178_RS16950	COG0572	uridine kinase
JN178_RS16955	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JN178_RS16980	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JN178_RS16980	COG0517	IMP dehydrogenase activity
JN178_RS16985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JN178_RS16995	COG2205	protein histidine kinase activity
JN178_RS16995	COG0784	Response regulator, receiver
JN178_RS17005	COG0189	ligase activity
JN178_RS17015	COG0189	ligase activity
JN178_RS17015	COG4067	protein conserved in archaea
JN178_RS17030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JN178_RS17040	COG1283	sodium-dependent phosphate transmembrane transporter activity
JN178_RS17045	COG0667	Aldo Keto reductase
JN178_RS17065	COG5001	Diguanylate cyclase
JN178_RS17065	COG3300	MHYT domain
JN178_RS17095	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
JN178_RS17105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JN178_RS17110	COG0840	transmembrane signaling receptor activity
JN178_RS17150	COG0583	DNA-binding transcription factor activity
JN178_RS17165	COG0438	transferase activity, transferring glycosyl groups
JN178_RS17165	COG1216	Glycosyl transferase, family 2
JN178_RS17200	COG1216	Glycosyl transferase, family 2
JN178_RS17200	COG1442	glycosyl transferase family 8
JN178_RS17205	COG0463	Glycosyl transferase, family 2
JN178_RS17255	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JN178_RS17260	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JN178_RS17285	COG0202	RNA polymerase activity
JN178_RS17310	COG0201	protein transport
JN178_RS17330	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JN178_RS17365	COG2205	protein histidine kinase activity
JN178_RS17365	COG0784	Response regulator, receiver
JN178_RS17380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JN178_RS17385	COG0557	exoribonuclease II activity
JN178_RS17410	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
JN178_RS17460	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
JN178_RS17470	COG4251	negative regulation of phosphorylation
JN178_RS17490	COG3706	GGDEF domain
JN178_RS17505	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
JN178_RS17505	COG0456	acetyltransferase
JN178_RS17515	COG0583	DNA-binding transcription factor activity
JN178_RS17535	COG1271	oxidase subunit
JN178_RS17540	COG1294	oxidase, subunit
JN178_RS17550	COG1522	sequence-specific DNA binding
JN178_RS17560	COG1278	Cold shock
JN178_RS17565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JN178_RS17585	COG0339	signal peptide processing
JN178_RS17590	COG2201	protein-glutamate methylesterase activity
JN178_RS17600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN178_RS17600	COG4191	Histidine kinase
JN178_RS17610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JN178_RS17615	COG3437	response regulator, receiver
JN178_RS17625	COG0823	Involved in the tonB-independent uptake of proteins
JN178_RS17625	COG1506	peptidase
JN178_RS17625	COG4946	Tricorn protease homolog
JN178_RS17660	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JN178_RS17665	COG1278	Cold shock
JN178_RS17685	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JN178_RS17690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JN178_RS17705	COG0281	malic enzyme
JN178_RS17715	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JN178_RS17745	COG0456	acetyltransferase
JN178_RS17755	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JN178_RS17760	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JN178_RS17765	COG2177	Part of the ABC transporter FtsEX involved in
JN178_RS17770	COG2884	Cell division ATP-binding protein ftsE
JN178_RS17775	COG0552	protein localization to endoplasmic reticulum
JN178_RS17780	COG0742	ribosomal rna small subunit methyltransferase
JN178_RS17790	COG2095	MarC family integral membrane protein
JN178_RS17810	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JN178_RS17815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JN178_RS17825	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JN178_RS17840	COG0076	glutamate decarboxylase activity
JN178_RS17855	COG0842	Transport permease protein
JN178_RS17860	COG1131	(ABC) transporter
JN178_RS17865	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JN178_RS17875	COG0745	RESPONSE REGULATOR receiver
JN178_RS17880	COG2205	protein histidine kinase activity
JN178_RS17885	COG4774	siderophore transport
JN178_RS17910	COG1253	flavin adenine dinucleotide binding
JN178_RS17915	COG0701	Predicted permease
JN178_RS17920	COG1966	Carbon starvation protein
JN178_RS17960	COG0848	biopolymer transport protein
JN178_RS17980	COG0657	acetylesterase activity
JN178_RS17995	COG1733	regulation of RNA biosynthetic process
JN178_RS18005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JN178_RS18010	COG0049	tRNA binding
JN178_RS18015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JN178_RS18020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JN178_RS18025	COG0085	RNA polymerase activity
JN178_RS18030	COG0222	ribosome binding
JN178_RS18035	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JN178_RS18040	COG0081	regulation of translation
JN178_RS18045	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JN178_RS18055	COG0250	Participates in transcription elongation, termination and antitermination
JN178_RS18060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JN178_RS18070	COG1132	(ABC) transporter
JN178_RS18080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JN178_RS18085	COG3590	peptidase
JN178_RS18100	COG0513	Belongs to the DEAD box helicase family
JN178_RS18110	COG0418	dihydroorotase activity
JN178_RS18115	COG3040	lipid binding
JN178_RS18120	COG4989	oxidoreductase activity
JN178_RS18125	COG0346	lactoylglutathione lyase activity
JN178_RS18130	COG0668	transmembrane transport
JN178_RS18150	COG0302	gtp cyclohydrolase
JN178_RS18160	COG2957	Belongs to the agmatine deiminase family
JN178_RS18165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JN178_RS18175	COG1201	RNA secondary structure unwinding
JN178_RS18185	COG1793	dna ligase
JN178_RS18190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JN178_RS18205	COG0583	DNA-binding transcription factor activity
JN178_RS18215	COG0625	glutathione transferase activity
JN178_RS18220	COG0625	glutathione transferase activity
JN178_RS18230	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JN178_RS18235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JN178_RS18245	COG1012	belongs to the aldehyde dehydrogenase family
JN178_RS18250	COG0028	Belongs to the TPP enzyme family
JN178_RS18260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JN178_RS18265	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JN178_RS18270	COG0330	HflC and HflK could
JN178_RS18275	COG0330	HflC and HflK could
JN178_RS18280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JN178_RS18285	COG1923	regulation of RNA biosynthetic process
JN178_RS18290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JN178_RS18295	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JN178_RS18300	COG0860	N-Acetylmuramoyl-L-alanine amidase
JN178_RS18305	COG0802	atpase or kinase
JN178_RS18310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JN178_RS18310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JN178_RS18315	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JN178_RS18330	COG2816	NAD+ diphosphatase activity
JN178_RS18340	COG0735	belongs to the Fur family
JN178_RS18360	COG0305	Participates in initiation and elongation during chromosome replication
JN178_RS18385	COG2258	MOSC domain
JN178_RS18430	COG1136	(ABC) transporter
JN178_RS18430	COG0577	efflux transmembrane transporter activity
JN178_RS18440	COG0840	transmembrane signaling receptor activity
JN178_RS18445	COG5002	protein histidine kinase activity
JN178_RS18450	COG0840	transmembrane signaling receptor activity
JN178_RS18465	COG2855	membrane
JN178_RS18475	COG0656	L-ascorbic acid biosynthetic process
JN178_RS18495	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JN178_RS18500	COG4771	TonB-dependent receptor
JN178_RS18530	COG1472	Belongs to the glycosyl hydrolase 3 family
JN178_RS18545	COG1609	Transcriptional regulator
JN178_RS18550	COG0477	Major facilitator Superfamily
JN178_RS18550	COG2814	Major facilitator Superfamily
JN178_RS18555	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JN178_RS18555	COG1618	nucleotide phosphatase activity, acting on free nucleotides
JN178_RS18560	COG4988	ABC transporter
JN178_RS18565	COG4890	Cyd operon protein YbgT
JN178_RS18570	COG1294	oxidase, subunit
JN178_RS18580	COG3829	transcription factor binding
JN178_RS18610	COG4319	ketosteroid isomerase
JN178_RS18615	COG1335	isochorismatase
JN178_RS18625	COG0402	S-adenosylhomocysteine deaminase activity
JN178_RS18630	COG1741	Belongs to the pirin family
JN178_RS18640	COG4771	TonB-dependent receptor
JN178_RS18655	COG1469	GTP cyclohydrolase I activity
JN178_RS18695	COG0811	peptide transport
JN178_RS18735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JN178_RS18770	COG5001	Diguanylate cyclase
JN178_RS18770	COG2203	Gaf domain
JN178_RS18770	COG3706	GGDEF domain
JN178_RS18770	COG4251	negative regulation of phosphorylation
JN178_RS18775	COG1477	protein flavinylation
JN178_RS18805	COG3237	CsbD-like
JN178_RS18820	COG0596	Alpha beta hydrolase
JN178_RS18820	COG0508	dehydrogenase complex catalyzes the overall conversion of
JN178_RS18845	COG3038	cytochrome b561
JN178_RS18850	COG2353	YceI-like domain
JN178_RS18855	COG1252	NADH dehydrogenase
JN178_RS18880	COG2067	long-chain fatty acid transport protein
JN178_RS18885	COG5001	Diguanylate cyclase
JN178_RS18885	COG3706	GGDEF domain
JN178_RS18885	COG2203	Gaf domain
JN178_RS18885	COG4251	negative regulation of phosphorylation
JN178_RS18890	COG4191	Histidine kinase
JN178_RS18895	COG2204	response regulator
JN178_RS18900	COG0577	efflux transmembrane transporter activity
JN178_RS18900	COG1136	(ABC) transporter
JN178_RS18905	COG1136	(ABC) transporter
JN178_RS18905	COG0577	efflux transmembrane transporter activity
JN178_RS18915	COG5001	Diguanylate cyclase
JN178_RS18915	COG5002	protein histidine kinase activity
JN178_RS18925	COG0010	Belongs to the arginase family
JN178_RS18930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JN178_RS18940	COG0673	inositol 2-dehydrogenase activity
JN178_RS18975	COG1166	arginine decarboxylase activity
JN178_RS18985	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JN178_RS19065	COG5001	Diguanylate cyclase
JN178_RS19070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JN178_RS19075	COG1695	Transcriptional regulator
JN178_RS19130	COG0328	RNA-DNA hybrid ribonuclease activity
JN178_RS19155	COG3030	protein affecting phage T7 exclusion by the F plasmid
JN178_RS19160	COG1324	tolerance protein
JN178_RS19165	COG4232	protein-disulfide reductase activity
JN178_RS19170	COG0739	heme binding
JN178_RS19175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JN178_RS19180	COG0511	ligase activity, forming carbon-carbon bonds
JN178_RS19185	COG0439	Biotin carboxylase
JN178_RS19235	COG0154	amidase activity
JN178_RS19250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JN178_RS19255	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
JN178_RS19270	COG0151	Belongs to the GarS family
JN178_RS19280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JN178_RS19285	COG3954	Phosphoribulokinase
JN178_RS19315	COG1501	Belongs to the glycosyl hydrolase 31 family
JN178_RS19325	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JN178_RS19330	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JN178_RS19340	COG3031	protein transport across the cell outer membrane
JN178_RS19350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JN178_RS19355	COG1459	type II secretion system
JN178_RS19360	COG2165	general secretion pathway protein
JN178_RS19365	COG2165	general secretion pathway protein
JN178_RS19370	COG2165	general secretion pathway protein
JN178_RS19375	COG4795	General secretion pathway protein
JN178_RS19390	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
JN178_RS19410	COG1012	belongs to the aldehyde dehydrogenase family
JN178_RS19420	COG1011	Hydrolase
JN178_RS19425	COG0494	nUDIX hydrolase
JN178_RS19430	COG1218	3'(2'),5'-bisphosphate nucleotidase
JN178_RS19440	COG2943	transferase activity, transferring hexosyl groups
JN178_RS19445	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
JN178_RS19455	COG3089	Belongs to the UPF0270 family
JN178_RS19460	COG0429	hydrolase of the alpha beta-hydrolase fold
JN178_RS19470	COG0488	(ABC) transporter
JN178_RS19510	COG0545	Peptidyl-prolyl cis-trans isomerase
JN178_RS19515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JN178_RS19520	COG2183	response to ionizing radiation
JN178_RS19535	COG0596	Alpha beta hydrolase
JN178_RS19540	COG1040	competence protein
JN178_RS19560	COG1794	racemase activity, acting on amino acids and derivatives
JN178_RS19575	COG0534	Mate efflux family protein
JN178_RS19580	COG1649	PFAM Uncharacterised BCR, COG1649
JN178_RS19580	COG0726	polysaccharide deacetylase
JN178_RS19590	COG1999	signal sequence binding
JN178_RS19595	COG0109	protoheme IX farnesyltransferase activity
JN178_RS19600	COG1612	heme a metabolic process
JN178_RS19625	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
JN178_RS19630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JN178_RS19635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JN178_RS19660	COG0129	dihydroxy-acid dehydratase activity
JN178_RS19665	COG2860	membrane
JN178_RS19670	COG0606	chelatase, subunit chli
JN178_RS19675	COG0583	DNA-binding transcription factor activity
JN178_RS19715	COG2814	Major facilitator Superfamily
JN178_RS19720	COG1073	alpha beta
JN178_RS19725	COG0729	surface antigen
JN178_RS19730	COG2911	Protein conserved in bacteria
JN178_RS19740	COG1595	DNA-templated transcription, initiation
JN178_RS19755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JN178_RS19765	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JN178_RS19785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JN178_RS19810	COG1228	amidohydrolase
JN178_RS19835	COG0425	Belongs to the sulfur carrier protein TusA family
JN178_RS19850	COG1561	YicC-like family, N-terminal region
JN178_RS19875	COG0270	DNA (cytosine-5-)-methyltransferase activity
JN178_RS19925	COG2211	Major facilitator Superfamily
JN178_RS19930	COG1609	Transcriptional regulator
JN178_RS19945	COG2199	diguanylate cyclase activity
JN178_RS19945	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JN178_RS19950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JN178_RS19970	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JN178_RS19990	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JN178_RS19995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JN178_RS20015	COG1475	DNA binding
JN178_RS20020	COG1192	Involved in chromosome partitioning
JN178_RS20035	COG0488	(ABC) transporter
JN178_RS20050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JN178_RS20055	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JN178_RS20090	COG0706	membrane insertase activity
JN178_RS20095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JN178_RS20100	COG0594	ribonuclease P activity
JN178_RS20105	COG0230	Belongs to the bacterial ribosomal protein bL34 family