locus-tag	class	description
CW735_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CW735_RS00020	COG0187	DNA topoisomerase II activity
CW735_RS00040	COG2818	Glycosylase
CW735_RS00050	COG3078	GTPase activator activity
CW735_RS00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CW735_RS00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CW735_RS00080	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CW735_RS00085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CW735_RS00090	COG0569	domain protein
CW735_RS00095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CW735_RS00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CW735_RS00110	COG1652	LysM domain
CW735_RS00115	COG0758	DNA mediated transformation
CW735_RS00125	COG0551	DNA topoisomerase type I activity
CW735_RS00130	COG0009	L-threonylcarbamoyladenylate synthase
CW735_RS00135	COG0408	coproporphyrinogen oxidase activity
CW735_RS00140	COG3047	cAMP biosynthetic process
CW735_RS00155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CW735_RS00215	COG2234	aminopeptidase activity
CW735_RS00240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CW735_RS00265	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CW735_RS00305	COG3642	lipopolysaccharide core region biosynthetic process
CW735_RS00310	COG0859	PFAM glycosyl transferase family 9
CW735_RS00340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CW735_RS00355	COG3161	chorismate lyase activity
CW735_RS00360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CW735_RS00365	COG2960	long-chain fatty acid transporting porin activity
CW735_RS00370	COG0210	DNA helicase
CW735_RS00390	COG1104	cysteine desulfurase activity
CW735_RS00400	COG4584	PFAM Integrase catalytic
CW735_RS00405	COG1484	DNA-dependent DNA replication
CW735_RS00420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CW735_RS00425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CW735_RS00430	COG1538	Outer membrane efflux protein
CW735_RS00450	COG2175	clavaminate synthase activity
CW735_RS00460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CW735_RS00460	COG4191	Histidine kinase
CW735_RS00480	COG1946	Acyl-CoA thioesterase
CW735_RS00525	COG3550	peptidyl-serine autophosphorylation
CW735_RS00530	COG1396	sequence-specific DNA binding
CW735_RS00555	COG0556	nucleotide-excision repair
CW735_RS00565	COG3550	peptidyl-serine autophosphorylation
CW735_RS00590	COG4585	Histidine kinase
CW735_RS00595	COG2197	response regulator
CW735_RS00615	COG2855	membrane
CW735_RS00625	COG0656	L-ascorbic acid biosynthetic process
CW735_RS00640	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CW735_RS00645	COG4771	TonB-dependent receptor
CW735_RS00670	COG4771	TonB-dependent receptor
CW735_RS00675	COG1960	acyl-CoA dehydrogenase activity
CW735_RS00680	COG0583	DNA-binding transcription factor activity
CW735_RS00690	COG3106	COG3106 Predicted ATPase
CW735_RS00705	COG3071	HemY protein
CW735_RS00710	COG2959	enzyme of heme biosynthesis
CW735_RS00720	COG0181	hydroxymethylbilane synthase activity
CW735_RS00730	COG0400	carboxylic ester hydrolase activity
CW735_RS00735	COG0194	GDP metabolic process
CW735_RS00745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CW735_RS00755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CW735_RS00760	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CW735_RS00770	COG0678	peroxiredoxin activity
CW735_RS00785	COG1178	ABC-type Fe3 transport system permease component
CW735_RS00790	COG3842	ATPase activity
CW735_RS00795	COG2081	HI0933 family
CW735_RS00815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CW735_RS00815	COG1181	Belongs to the D-alanine--D-alanine ligase family
CW735_RS00860	COG2200	EAL domain
CW735_RS00895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CW735_RS00925	COG0427	acetyl-CoA hydrolase
CW735_RS00930	COG0123	including yeast histone deacetylase and acetoin utilization protein
CW735_RS00945	COG0840	transmembrane signaling receptor activity
CW735_RS00955	COG3064	Membrane
CW735_RS00965	COG5001	Diguanylate cyclase
CW735_RS00965	COG5002	protein histidine kinase activity
CW735_RS00980	COG0514	ATP-dependent DNA helicase (RecQ)
CW735_RS00985	COG2239	Acts as a magnesium transporter
CW735_RS00990	COG2962	Rard protein
CW735_RS01000	COG0210	DNA helicase
CW735_RS01010	COG1011	Hydrolase
CW735_RS01015	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CW735_RS01025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CW735_RS01030	COG0019	diaminopimelate decarboxylase activity
CW735_RS01050	COG0671	phosphoesterase, PA-phosphatase related
CW735_RS01065	COG0163	prenyltransferase activity
CW735_RS01070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CW735_RS01080	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CW735_RS01115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CW735_RS01120	COG0577	efflux transmembrane transporter activity
CW735_RS01120	COG1136	(ABC) transporter
CW735_RS01135	COG1077	Cell shape determining protein MreB Mrl
CW735_RS01145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CW735_RS01150	COG2814	Major facilitator Superfamily
CW735_RS01170	COG1085	galactose-1-phosphate uridylyltransferase
CW735_RS01175	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CW735_RS01205	COG3344	reverse transcriptase
CW735_RS01225	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CW735_RS01250	COG1349	DNA-binding transcription factor activity
CW735_RS01265	COG1077	Cell shape determining protein MreB Mrl
CW735_RS01270	COG1792	Involved in formation and maintenance of cell shape
CW735_RS01275	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CW735_RS01285	COG1530	ribonuclease E activity
CW735_RS01290	COG3164	Protein of unknown function
CW735_RS01295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CW735_RS01300	COG0312	modulator of DNA gyrase
CW735_RS01305	COG3028	Belongs to the UPF0307 family
CW735_RS01310	COG0312	modulator of DNA gyrase
CW735_RS01345	COG0745	RESPONSE REGULATOR receiver
CW735_RS01350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CW735_RS01350	COG4191	Histidine kinase
CW735_RS01355	COG0297	glycogen (starch) synthase activity
CW735_RS01365	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CW735_RS01370	COG0596	Alpha beta hydrolase
CW735_RS01370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CW735_RS01370	COG2226	methyltransferase
CW735_RS01430	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CW735_RS01435	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CW735_RS01500	COG0443	Heat shock 70 kDa protein
CW735_RS01540	COG3706	GGDEF domain
CW735_RS01550	COG0546	phosphoglycolate phosphatase activity
CW735_RS01565	COG1454	alcohol dehydrogenase
CW735_RS01605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CW735_RS01610	COG0051	transcription antitermination factor activity, RNA binding
CW735_RS01625	COG0089	rRNA binding
CW735_RS01635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CW735_RS01645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CW735_RS01660	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CW735_RS01665	COG1519	Transferase
CW735_RS01680	COG0840	transmembrane signaling receptor activity
CW735_RS01700	COG0788	formyltetrahydrofolate deformylase activity
CW735_RS01710	COG1643	Atp-dependent helicase
CW735_RS01715	COG5001	Diguanylate cyclase
CW735_RS01715	COG4251	negative regulation of phosphorylation
CW735_RS01715	COG3706	GGDEF domain
CW735_RS01715	COG2203	Gaf domain
CW735_RS01725	COG2951	lytic endotransglycosylase activity
CW735_RS01730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CW735_RS01740	COG2354	Protein conserved in bacteria
CW735_RS01755	COG0004	ammonium transporteR
CW735_RS01760	COG0405	Gamma-glutamyltransferase
CW735_RS01765	COG2837	iron assimilation
CW735_RS01780	COG0540	Belongs to the ATCase OTCase family
CW735_RS01790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CW735_RS01805	COG3850	Histidine kinase
CW735_RS01805	COG3437	response regulator, receiver
CW735_RS01805	COG4999	Histidine kinase
CW735_RS01805	COG2205	protein histidine kinase activity
CW735_RS01820	COG5001	Diguanylate cyclase
CW735_RS01820	COG3300	MHYT domain
CW735_RS01830	COG1012	belongs to the aldehyde dehydrogenase family
CW735_RS01835	COG3138	arginine N-succinyltransferase
CW735_RS01840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CW735_RS01850	COG0512	Glutamine amidotransferase of anthranilate synthase
CW735_RS01855	COG0180	Tryptophanyl-tRNA synthetase
CW735_RS01860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CW735_RS01890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CW735_RS01925	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CW735_RS01930	COG0281	malic enzyme
CW735_RS01960	COG0746	molybdenum cofactor guanylyltransferase activity
CW735_RS01970	COG1116	anion transmembrane transporter activity
CW735_RS01980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CW735_RS01980	COG1116	anion transmembrane transporter activity
CW735_RS01985	COG1648	precorrin-2 dehydrogenase activity
CW735_RS01985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CW735_RS01990	COG0243	molybdopterin cofactor binding
CW735_RS02000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CW735_RS02000	COG2146	nitrite reductase [NAD(P)H] activity
CW735_RS02010	COG2116	formate transmembrane transporter activity
CW735_RS02020	COG0303	'Molybdopterin
CW735_RS02035	COG0625	glutathione transferase activity
CW735_RS02050	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CW735_RS02050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CW735_RS02060	COG0137	argininosuccinate synthase activity
CW735_RS02065	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CW735_RS02080	COG1803	Methylglyoxal synthase
CW735_RS02095	COG0745	RESPONSE REGULATOR receiver
CW735_RS02110	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CW735_RS02115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CW735_RS02125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CW735_RS02130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CW735_RS02135	COG4942	peptidase
CW735_RS02140	COG2861	carbohydrate metabolic process
CW735_RS02150	COG0584	glycerophosphoryl diester phosphodiesterase
CW735_RS02165	COG1162	GTPase activity
CW735_RS02170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CW735_RS02205	COG0028	Belongs to the TPP enzyme family
CW735_RS02225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CW735_RS02230	COG0805	protein transport
CW735_RS02240	COG0084	hydrolase, TatD family'
CW735_RS02245	COG3706	GGDEF domain
CW735_RS02255	COG0248	Ppx GppA phosphatase
CW735_RS02260	COG0513	Belongs to the DEAD box helicase family
CW735_RS02265	COG3118	belongs to the thioredoxin family
CW735_RS02270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CW735_RS02275	COG1473	amidohydrolase
CW735_RS02280	COG2205	protein histidine kinase activity
CW735_RS02280	COG0784	Response regulator, receiver
CW735_RS02285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CW735_RS02290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CW735_RS02300	COG2847	Copper chaperone PCu(A)C
CW735_RS02305	COG0783	Belongs to the Dps family
CW735_RS02310	COG2133	pyrroloquinoline quinone binding
CW735_RS02315	COG4946	Tricorn protease homolog
CW735_RS02315	COG1506	peptidase
CW735_RS02315	COG0823	Involved in the tonB-independent uptake of proteins
CW735_RS02325	COG3118	belongs to the thioredoxin family
CW735_RS02340	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CW735_RS02350	COG1012	belongs to the aldehyde dehydrogenase family
CW735_RS02370	COG1757	Na H antiporter
CW735_RS02380	COG3876	Protein conserved in bacteria
CW735_RS02385	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CW735_RS02460	COG3547	Transposase (IS116 IS110 IS902 family)
CW735_RS02490	COG4372	Transposase
CW735_RS02560	COG3344	reverse transcriptase
CW735_RS02585	COG0183	Belongs to the thiolase family
CW735_RS02590	COG1250	3-hydroxyacyl-CoA dehydrogenase
CW735_RS02590	COG1024	Enoyl-CoA hydratase
CW735_RS02600	COG0006	proline dipeptidase activity
CW735_RS02610	COG0142	geranyltranstransferase activity
CW735_RS02640	COG1388	LysM domain
CW735_RS02640	COG4942	peptidase
CW735_RS02645	COG1238	metal cluster binding
CW735_RS02655	COG0585	pseudouridine synthase activity
CW735_RS02670	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CW735_RS02680	COG0840	transmembrane signaling receptor activity
CW735_RS02695	COG3025	triphosphatase activity
CW735_RS02705	COG3066	DNA modification
CW735_RS02710	COG0494	nUDIX hydrolase
CW735_RS02715	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CW735_RS02720	COG0730	response to heat
CW735_RS02725	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CW735_RS02735	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CW735_RS02760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CW735_RS02815	COG2201	protein-glutamate methylesterase activity
CW735_RS02820	COG3706	GGDEF domain
CW735_RS02825	COG2211	Major facilitator Superfamily
CW735_RS02845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CW735_RS02855	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CW735_RS02865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CW735_RS02865	COG1648	precorrin-2 dehydrogenase activity
CW735_RS02870	COG0513	Belongs to the DEAD box helicase family
CW735_RS02885	COG1538	Outer membrane efflux protein
CW735_RS02890	COG0494	nUDIX hydrolase
CW735_RS02895	COG3151	Protein conserved in bacteria
CW735_RS02900	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CW735_RS02905	COG3150	esterase
CW735_RS02935	COG1509	lysine 2,3-aminomutase activity
CW735_RS02940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CW735_RS02945	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CW735_RS02985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CW735_RS03000	COG0271	Belongs to the BolA IbaG family
CW735_RS03005	COG0671	phosphoesterase, PA-phosphatase related
CW735_RS03020	COG0659	secondary active sulfate transmembrane transporter activity
CW735_RS03035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CW735_RS03045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CW735_RS03055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CW735_RS03060	COG0348	domain, Protein
CW735_RS03075	COG1960	acyl-CoA dehydrogenase activity
CW735_RS03080	COG1028	Short-chain dehydrogenase reductase Sdr
CW735_RS03090	COG4948	Mandelate Racemase Muconate Lactonizing
CW735_RS03110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CW735_RS03115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CW735_RS03150	COG0358	DNA primase activity
CW735_RS03175	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CW735_RS03195	COG0537	adenosine 5'-monophosphoramidase activity
CW735_RS03210	COG3135	benzoate transporter
CW735_RS03215	COG1396	sequence-specific DNA binding
CW735_RS03220	COG2974	May be involved in recombination
CW735_RS03230	COG0745	RESPONSE REGULATOR receiver
CW735_RS03235	COG5002	protein histidine kinase activity
CW735_RS03265	COG0811	peptide transport
CW735_RS03270	COG0811	peptide transport
CW735_RS03275	COG0848	biopolymer transport protein
CW735_RS03280	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CW735_RS03290	COG3437	response regulator, receiver
CW735_RS03315	COG2133	pyrroloquinoline quinone binding
CW735_RS03320	COG1049	propionate catabolic process, 2-methylcitrate cycle
CW735_RS03335	COG3850	Histidine kinase
CW735_RS03335	COG4999	Histidine kinase
CW735_RS03335	COG2205	protein histidine kinase activity
CW735_RS03335	COG3437	response regulator, receiver
CW735_RS03370	COG0463	Glycosyl transferase, family 2
CW735_RS03385	COG5433	transposase activity
CW735_RS03410	COG2205	protein histidine kinase activity
CW735_RS03425	COG0463	Glycosyl transferase, family 2
CW735_RS03440	COG0751	glycine-tRNA ligase activity
CW735_RS03510	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CW735_RS03520	COG4771	TonB-dependent receptor
CW735_RS03550	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CW735_RS03555	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CW735_RS03565	COG0527	aspartate kinase activity
CW735_RS03585	COG2967	ApaG domain
CW735_RS03590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CW735_RS03595	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CW735_RS03600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CW735_RS03605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CW735_RS03610	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CW735_RS03620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CW735_RS03625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CW735_RS03640	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CW735_RS03655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CW735_RS03660	COG3956	TIGRFAM MazG family protein
CW735_RS03685	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CW735_RS03690	COG0723	plastoquinol--plastocyanin reductase activity
CW735_RS03695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CW735_RS03700	COG2857	Cytochrome c1
CW735_RS03705	COG0625	glutathione transferase activity
CW735_RS03710	COG2969	positive regulation of protein catabolic process
CW735_RS03715	COG0583	DNA-binding transcription factor activity
CW735_RS03750	COG2239	Acts as a magnesium transporter
CW735_RS03755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CW735_RS03775	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CW735_RS03780	COG1137	ATPase activity
CW735_RS03785	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CW735_RS03810	COG1127	ABC transporter
CW735_RS03815	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CW735_RS03820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CW735_RS03825	COG2854	intermembrane phospholipid transfer
CW735_RS03835	COG5007	Belongs to the BolA IbaG family
CW735_RS03845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CW735_RS03850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CW735_RS03860	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CW735_RS03870	COG3706	GGDEF domain
CW735_RS03875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CW735_RS03880	COG0612	Peptidase, M16
CW735_RS03890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CW735_RS03915	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CW735_RS03925	COG0126	phosphoglycerate kinase activity
CW735_RS03930	COG3588	fructose-bisphosphate aldolase
CW735_RS03985	COG2311	Membrane
CW735_RS03990	COG0248	Ppx GppA phosphatase
CW735_RS03995	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CW735_RS04005	COG0573	inorganic phosphate transmembrane transporter activity
CW735_RS04015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CW735_RS04025	COG0306	phosphate transporter
CW735_RS04030	COG0589	response to stress
CW735_RS04035	COG0583	DNA-binding transcription factor activity
CW735_RS04045	COG1272	protein, Hemolysin III
CW735_RS04060	COG1846	Transcriptional regulator
CW735_RS04065	COG1764	response to oxidative stress
CW735_RS04090	COG3112	Uncharacterised protein family (UPF0231)
CW735_RS04095	COG1451	nucleotide metabolic process
CW735_RS04100	COG1739	Uncharacterized protein family UPF0029
CW735_RS04120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CW735_RS04125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CW735_RS04150	COG0420	3'-5' exonuclease activity
CW735_RS04155	COG0419	ATPase involved in DNA repair
CW735_RS04160	COG0596	Alpha beta hydrolase
CW735_RS04165	COG3706	GGDEF domain
CW735_RS04180	COG2971	BadF BadG BcrA BcrD
CW735_RS04185	COG0488	(ABC) transporter
CW735_RS04190	COG3002	Belongs to the UPF0753 family
CW735_RS04195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CW735_RS04200	COG0009	L-threonylcarbamoyladenylate synthase
CW735_RS04205	COG0583	DNA-binding transcription factor activity
CW735_RS04220	COG0668	transmembrane transport
CW735_RS04350	COG1346	cytolysis
CW735_RS04380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CW735_RS04385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CW735_RS04390	COG0513	Belongs to the DEAD box helicase family
CW735_RS04395	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW735_RS04405	COG3267	Type II secretory pathway component ExeA
CW735_RS04405	COG3409	Peptidoglycan-binding domain 1 protein
CW735_RS04420	COG1757	Na H antiporter
CW735_RS04425	COG0066	3-isopropylmalate dehydratase activity
CW735_RS04435	COG0473	3-isopropylmalate dehydrogenase activity
CW735_RS04440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CW735_RS04460	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CW735_RS04490	COG4555	ABC transporter
CW735_RS04495	COG1668	transmembrane transport
CW735_RS04520	COG4133	protoheme IX ABC transporter activity
CW735_RS04525	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CW735_RS04530	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CW735_RS04535	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CW735_RS04545	COG1138	Cytochrome C-type biogenesis protein
CW735_RS04565	COG2853	Lipoprotein
CW735_RS04570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CW735_RS04580	COG3104	oligopeptide transport
CW735_RS04590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CW735_RS04595	COG1555	photosystem II stabilization
CW735_RS04595	COG1596	polysaccharide export
CW735_RS04600	COG0473	3-isopropylmalate dehydrogenase activity
CW735_RS04620	COG1611	Belongs to the LOG family
CW735_RS04630	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CW735_RS04630	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CW735_RS04710	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CW735_RS04715	COG0024	Methionine aminopeptidase
CW735_RS04725	COG0052	Belongs to the universal ribosomal protein uS2 family
CW735_RS04735	COG0528	UMP kinase activity
CW735_RS04745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CW735_RS04750	COG0575	Belongs to the CDS family
CW735_RS04755	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CW735_RS04775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CW735_RS04795	COG0587	DNA-directed DNA polymerase activity
CW735_RS04800	COG0825	malonyl-CoA metabolic process
CW735_RS04805	COG0037	tRNA processing
CW735_RS04810	COG3706	GGDEF domain
CW735_RS04835	COG0047	phosphoribosylformylglycinamidine synthase activity
CW735_RS04835	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CW735_RS04840	COG2840	Smr protein MutS2
CW735_RS04875	COG0784	Response regulator, receiver
CW735_RS04875	COG0835	chemotaxis
CW735_RS04880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CW735_RS04885	COG1815	bacterial-type flagellum-dependent cell motility
CW735_RS04895	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CW735_RS04905	COG4787	bacterial-type flagellum-dependent cell motility
CW735_RS04925	COG3951	Flagellar rod assembly protein muramidase FlgJ
CW735_RS04925	COG1705	Flagellar rod assembly protein muramidase FlgJ
CW735_RS04945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CW735_RS04960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CW735_RS04970	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CW735_RS05005	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CW735_RS05030	COG1028	Short-chain dehydrogenase reductase Sdr
CW735_RS05035	COG3958	Transketolase
CW735_RS05040	COG3959	Transketolase, thiamine diphosphate binding domain
CW735_RS05065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CW735_RS05070	COG1086	Polysaccharide biosynthesis protein
CW735_RS05095	COG1677	Flagellar hook-basal body complex protein FliE
CW735_RS05100	COG1766	The M ring may be actively involved in energy transduction
CW735_RS05105	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CW735_RS05155	COG1987	bacterial-type flagellum assembly
CW735_RS05170	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CW735_RS05195	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CW735_RS05200	COG0784	Response regulator, receiver
CW735_RS05200	COG0643	Histidine kinase
CW735_RS05200	COG2198	Histidine kinase
CW735_RS05210	COG1192	Involved in chromosome partitioning
CW735_RS05220	COG0835	chemotaxis
CW735_RS05235	COG0646	methionine synthase
CW735_RS05235	COG1410	methionine synthase
CW735_RS05240	COG1410	methionine synthase
CW735_RS05240	COG0646	methionine synthase
CW735_RS05250	COG3123	guanosine phosphorylase activity
CW735_RS05255	COG0583	DNA-binding transcription factor activity
CW735_RS05260	COG0583	DNA-binding transcription factor activity
CW735_RS05265	COG0288	reversible hydration of carbon dioxide
CW735_RS05270	COG0659	secondary active sulfate transmembrane transporter activity
CW735_RS05275	COG1309	transcriptional regulator
CW735_RS05280	COG3590	peptidase
CW735_RS05295	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CW735_RS05325	COG0511	ligase activity, forming carbon-carbon bonds
CW735_RS05325	COG5016	pyruvate
CW735_RS05330	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CW735_RS05335	COG4172	Belongs to the ABC transporter superfamily
CW735_RS05345	COG4171	peptide transport system, permease
CW735_RS05350	COG4168	peptide transport system, permease
CW735_RS05355	COG0747	negative chemotaxis
CW735_RS05360	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CW735_RS05365	COG1842	Phage shock protein A
CW735_RS05380	COG3186	Phenylalanine-4-hydroxylase
CW735_RS05395	COG0625	glutathione transferase activity
CW735_RS05400	COG1522	sequence-specific DNA binding
CW735_RS05450	COG0811	peptide transport
CW735_RS05455	COG0811	peptide transport
CW735_RS05460	COG0848	biopolymer transport protein
CW735_RS05475	COG1444	tRNA N-acetyltransferase activity
CW735_RS05515	COG0456	acetyltransferase
CW735_RS05560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CW735_RS05600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CW735_RS05605	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CW735_RS05610	COG0564	pseudouridine synthase activity
CW735_RS05620	COG0612	Peptidase, M16
CW735_RS05625	COG2918	glutathione biosynthetic process
CW735_RS05635	COG2840	Smr protein MutS2
CW735_RS05640	COG2890	protein-(glutamine-N5) methyltransferase activity
CW735_RS05655	COG2719	SpoVR family
CW735_RS05660	COG2718	Belongs to the UPF0229 family
CW735_RS05665	COG2766	serine protein kinase
CW735_RS05675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CW735_RS05680	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CW735_RS05685	COG4771	TonB-dependent receptor
CW735_RS05720	COG0584	glycerophosphoryl diester phosphodiesterase
CW735_RS05725	COG0346	lactoylglutathione lyase activity
CW735_RS05730	COG1278	Cold shock
CW735_RS05745	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CW735_RS05750	COG4660	Part of a membrane complex involved in electron transport
CW735_RS05755	COG4659	FMN binding
CW735_RS05760	COG4658	electron transport chain
CW735_RS05765	COG4656	Part of a membrane complex involved in electron transport
CW735_RS05770	COG2878	Part of a membrane complex involved in electron transport
CW735_RS05775	COG4657	Part of a membrane complex involved in electron transport
CW735_RS05790	COG0534	Mate efflux family protein
CW735_RS05795	COG0556	nucleotide-excision repair
CW735_RS05820	COG0602	queuosine metabolic process
CW735_RS05830	COG0367	asparagine synthase
CW735_RS05850	COG0471	metal ion transport
CW735_RS05850	COG3273	potassium ion transport
CW735_RS05865	COG0529	Catalyzes the synthesis of activated sulfate
CW735_RS05870	COG0175	sulfate reduction
CW735_RS05875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CW735_RS05915	COG2304	oxidoreductase activity
CW735_RS05935	COG0714	Associated with various cellular activities
CW735_RS05945	COG1250	3-hydroxyacyl-CoA dehydrogenase
CW735_RS05945	COG1024	Enoyl-CoA hydratase
CW735_RS05970	COG1025	Belongs to the peptidase M16 family
CW735_RS05975	COG2062	phosphohistidine phosphatase, SixA
CW735_RS05985	COG4536	flavin adenine dinucleotide binding
CW735_RS05990	COG4137	Cytochrome C assembly protein
CW735_RS05995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CW735_RS06025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CW735_RS06035	COG1132	(ABC) transporter
CW735_RS06040	COG0668	transmembrane transport
CW735_RS06050	COG0228	four-way junction DNA binding
CW735_RS06055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CW735_RS06060	COG0336	Belongs to the RNA methyltransferase TrmD family
CW735_RS06065	COG0335	large ribosomal subunit rRNA binding
CW735_RS06080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CW735_RS06085	COG0287	Prephenate dehydrogenase
CW735_RS06085	COG1605	Chorismate mutase
CW735_RS06090	COG1605	Chorismate mutase
CW735_RS06090	COG0077	Prephenate dehydratase
CW735_RS06095	COG0745	RESPONSE REGULATOR receiver
CW735_RS06100	COG0023	Translation Initiation Factor
CW735_RS06130	COG2205	protein histidine kinase activity
CW735_RS06140	COG2204	response regulator
CW735_RS06150	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CW735_RS06155	COG0494	nUDIX hydrolase
CW735_RS06160	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CW735_RS06165	COG0632	four-way junction helicase activity
CW735_RS06170	COG2255	four-way junction helicase activity
CW735_RS06175	COG0824	Thioesterase
CW735_RS06180	COG0811	peptide transport
CW735_RS06195	COG0823	Involved in the tonB-independent uptake of proteins
CW735_RS06200	COG2885	chlorophyll binding
CW735_RS06205	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CW735_RS06225	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CW735_RS06250	COG3706	GGDEF domain
CW735_RS06280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CW735_RS06290	COG1309	transcriptional regulator
CW735_RS06310	COG3706	GGDEF domain
CW735_RS06320	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CW735_RS06320	COG3008	intermembrane lipid transfer
CW735_RS06325	COG2995	paraquat-inducible protein a
CW735_RS06335	COG2031	fatty acid transporter
CW735_RS06340	COG0017	Asparaginyl-tRNA synthetase
CW735_RS06375	COG0156	8-amino-7-oxononanoate synthase activity
CW735_RS06380	COG1073	alpha beta
CW735_RS06380	COG2226	methyltransferase
CW735_RS06390	COG3340	Belongs to the peptidase S51 family
CW735_RS06395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CW735_RS06400	COG4139	cobalamin transport
CW735_RS06405	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CW735_RS06410	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CW735_RS06425	COG5265	(ABC) transporter
CW735_RS06450	COG5002	protein histidine kinase activity
CW735_RS06450	COG2205	protein histidine kinase activity
CW735_RS06450	COG0784	Response regulator, receiver
CW735_RS06455	COG0745	RESPONSE REGULATOR receiver
CW735_RS06480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CW735_RS06530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CW735_RS06535	COG0402	S-adenosylhomocysteine deaminase activity
CW735_RS06555	COG2755	lipolytic protein G-D-S-L family
CW735_RS06560	COG4181	ATPase activity
CW735_RS06565	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CW735_RS06570	COG1090	epimerase
CW735_RS06575	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CW735_RS06580	COG0628	permease
CW735_RS06605	COG2350	Protein conserved in bacteria
CW735_RS06610	COG0159	tryptophan synthase activity
CW735_RS06620	COG0134	indole-3-glycerol-phosphate synthase activity
CW735_RS06620	COG0135	phosphoribosylanthranilate isomerase activity
CW735_RS06625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CW735_RS06635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CW735_RS06640	COG0613	PHP domain protein
CW735_RS06645	COG0009	L-threonylcarbamoyladenylate synthase
CW735_RS06655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CW735_RS06660	COG1187	pseudouridine synthase activity
CW735_RS06665	COG0656	L-ascorbic acid biosynthetic process
CW735_RS06680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CW735_RS06695	COG0110	maltose O-acetyltransferase activity
CW735_RS06705	COG2733	membrane
CW735_RS06710	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CW735_RS06715	COG0534	Mate efflux family protein
CW735_RS06725	COG4774	siderophore transport
CW735_RS06725	COG1629	transport
CW735_RS06735	COG0500	methyltransferase
CW735_RS06740	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CW735_RS06745	COG0497	DNA recombination
CW735_RS06755	COG0783	Belongs to the Dps family
CW735_RS06760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CW735_RS06765	COG1028	Short-chain dehydrogenase reductase Sdr
CW735_RS06775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CW735_RS06780	COG2610	gluconate transmembrane transporter activity
CW735_RS06795	COG0625	glutathione transferase activity
CW735_RS06815	COG3562	capsule polysaccharide
CW735_RS06825	COG0675	Transposase, IS605 OrfB family
CW735_RS06830	COG0784	Response regulator, receiver
CW735_RS06830	COG5002	protein histidine kinase activity
CW735_RS06840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CW735_RS06850	COG0484	heat shock protein binding
CW735_RS06860	COG3909	cytochrome
CW735_RS06875	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CW735_RS06885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CW735_RS06890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CW735_RS06900	COG0071	Belongs to the small heat shock protein (HSP20) family
CW735_RS06905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CW735_RS06910	COG0857	belongs to the CobB CobQ family
CW735_RS06910	COG0280	phosphate acetyltransferase
CW735_RS06925	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CW735_RS06940	COG2944	sequence-specific DNA binding
CW735_RS06945	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
CW735_RS06955	COG1181	Belongs to the D-alanine--D-alanine ligase family
CW735_RS06955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CW735_RS06965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CW735_RS06970	COG4535	Mg2 and Co2 transporter CorC
CW735_RS06980	COG1702	phosphate starvation-inducible protein PhoH
CW735_RS06990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CW735_RS07035	COG1607	acyl-coa hydrolase
CW735_RS07040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CW735_RS07055	COG0318	PFAM AMP-dependent synthetase and ligase
CW735_RS07060	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CW735_RS07075	COG0179	Fumarylacetoacetate (FAA) hydrolase
CW735_RS07080	COG2983	Belongs to the UPF0260 family
CW735_RS07085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CW735_RS07090	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CW735_RS07100	COG2186	Transcriptional regulator
CW735_RS07125	COG4399	Belongs to the UPF0754 family
CW735_RS07135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CW735_RS07155	COG1024	Enoyl-CoA hydratase
CW735_RS07160	COG1902	pentaerythritol trinitrate reductase activity
CW735_RS07160	COG0446	pyridine nucleotide-disulphide oxidoreductase
CW735_RS07165	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CW735_RS07185	COG0352	thiamine-phosphate diphosphorylase activity
CW735_RS07195	COG1620	l-lactate permease
CW735_RS07215	COG3101	peptidyl-lysine hydroxylation
CW735_RS07310	COG3344	reverse transcriptase
CW735_RS07340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CW735_RS07340	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CW735_RS07345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CW735_RS07360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CW735_RS07385	COG0285	dihydrofolate synthase activity
CW735_RS07390	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CW735_RS07395	COG1286	toxin biosynthetic process
CW735_RS07400	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CW735_RS07425	COG0604	alcohol dehydrogenase
CW735_RS07430	COG0784	Response regulator, receiver
CW735_RS07430	COG2205	protein histidine kinase activity
CW735_RS07435	COG0604	alcohol dehydrogenase
CW735_RS07440	COG1733	regulation of RNA biosynthetic process
CW735_RS07475	COG1785	Belongs to the alkaline phosphatase family
CW735_RS07480	COG1785	Belongs to the alkaline phosphatase family
CW735_RS07490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CW735_RS07495	COG0215	cysteine-tRNA ligase activity
CW735_RS07500	COG0545	Peptidyl-prolyl cis-trans isomerase
CW735_RS07510	COG1388	LysM domain
CW735_RS07510	COG0741	lytic transglycosylase activity
CW735_RS07515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CW735_RS07520	COG2226	methyltransferase
CW735_RS07525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CW735_RS07525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CW735_RS07530	COG0489	protein tyrosine kinase activity
CW735_RS07545	COG0471	metal ion transport
CW735_RS07565	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CW735_RS07570	COG3177	Filamentation induced by cAMP protein fic
CW735_RS07575	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CW735_RS07595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CW735_RS07605	COG4372	Transposase
CW735_RS07610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CW735_RS07615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CW735_RS07630	COG1741	Belongs to the pirin family
CW735_RS07660	COG0840	transmembrane signaling receptor activity
CW735_RS07675	COG0142	geranyltranstransferase activity
CW735_RS07700	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CW735_RS07710	COG1979	alcohol dehydrogenase
CW735_RS07720	COG0583	DNA-binding transcription factor activity
CW735_RS07780	COG2823	Periplasmic or secreted lipoprotein
CW735_RS07785	COG3344	reverse transcriptase
CW735_RS07790	COG1448	Aminotransferase
CW735_RS07845	COG1024	Enoyl-CoA hydratase
CW735_RS07850	COG0405	Gamma-glutamyltransferase
CW735_RS07855	COG0295	cytidine deaminase activity
CW735_RS07875	COG1196	nuclear chromosome segregation
CW735_RS07885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CW735_RS07895	COG2333	competence protein COMEC
CW735_RS07895	COG0658	competence protein
CW735_RS07900	COG1132	(ABC) transporter
CW735_RS07905	COG1663	tetraacyldisaccharide 4'-kinase activity
CW735_RS07945	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CW735_RS07950	COG0435	Glutathione S-transferase
CW735_RS07975	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CW735_RS07980	COG1053	succinate dehydrogenase
CW735_RS07985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CW735_RS07990	COG0567	Dehydrogenase, E1 component
CW735_RS07995	COG0508	dehydrogenase complex catalyzes the overall conversion of
CW735_RS08030	COG4667	esterase of the alpha-beta hydrolase superfamily
CW735_RS08050	COG0366	Alpha amylase catalytic
CW735_RS08075	COG1028	Short-chain dehydrogenase reductase Sdr
CW735_RS08080	COG2267	carboxylic ester hydrolase activity
CW735_RS08085	COG0616	signal peptide processing
CW735_RS08095	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CW735_RS08100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CW735_RS08105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CW735_RS08110	COG0386	Belongs to the glutathione peroxidase family
CW735_RS08115	COG2084	Dehydrogenase
CW735_RS08125	COG1960	acyl-CoA dehydrogenase activity
CW735_RS08130	COG1024	Enoyl-CoA hydratase
CW735_RS08135	COG2226	methyltransferase
CW735_RS08140	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CW735_RS08145	COG3083	sulfuric ester hydrolase activity
CW735_RS08150	COG3082	Protein of unknown function (DUF1414)
CW735_RS08155	COG3081	Nucleoid-associated protein
CW735_RS08165	COG0739	heme binding
CW735_RS08185	COG3275	phosphorelay sensor kinase activity
CW735_RS08190	COG3279	Response regulator of the LytR AlgR family
CW735_RS08195	COG0205	6-phosphofructokinase activity
CW735_RS08205	COG0745	RESPONSE REGULATOR receiver
CW735_RS08215	COG1054	Belongs to the UPF0176 family
CW735_RS08225	COG0513	Belongs to the DEAD box helicase family
CW735_RS08230	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CW735_RS08235	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CW735_RS08240	COG0583	DNA-binding transcription factor activity
CW735_RS08260	COG1760	l-serine dehydratase
CW735_RS08270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CW735_RS08280	COG1322	Protein conserved in bacteria
CW735_RS08295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CW735_RS08300	COG0022	dehydrogenase e1 component
CW735_RS08310	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CW735_RS08320	COG1946	Acyl-CoA thioesterase
CW735_RS08330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CW735_RS08340	COG1956	GAF domain-containing protein
CW735_RS08355	COG0793	Belongs to the peptidase S41A family
CW735_RS08360	COG0733	neurotransmitter:sodium symporter activity
CW735_RS08365	COG1757	Na H antiporter
CW735_RS08370	COG0308	aminopeptidase N
CW735_RS08400	COG2902	Dehydrogenase
CW735_RS08405	COG0167	dihydroorotate dehydrogenase activity
CW735_RS08420	COG0488	(ABC) transporter
CW735_RS08430	COG3130	regulation of translation
CW735_RS08440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CW735_RS08450	COG0415	Belongs to the DNA photolyase family
CW735_RS08455	COG0415	Belongs to the DNA photolyase family
CW735_RS08460	COG0415	Belongs to the DNA photolyase family
CW735_RS08465	COG3046	protein related to deoxyribodipyrimidine photolyase
CW735_RS08480	COG1757	Na H antiporter
CW735_RS08505	COG5002	protein histidine kinase activity
CW735_RS08510	COG0745	RESPONSE REGULATOR receiver
CW735_RS08535	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CW735_RS08580	COG1028	Short-chain dehydrogenase reductase Sdr
CW735_RS08630	COG0789	Transcriptional regulator
CW735_RS08635	COG2217	Heavy metal translocating P-type atpase
CW735_RS08665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CW735_RS08730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CW735_RS08735	COG0789	Transcriptional regulator
CW735_RS08775	COG3667	copper resistance
CW735_RS08780	COG2132	Multicopper oxidase
CW735_RS08805	COG4977	sequence-specific DNA binding
CW735_RS08810	COG0789	Transcriptional regulator
CW735_RS08960	COG2059	Chromate
CW735_RS09105	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CW735_RS09115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CW735_RS09120	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CW735_RS09145	COG2200	EAL domain
CW735_RS09160	COG0633	Ferredoxin
CW735_RS09165	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CW735_RS09170	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CW735_RS09175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CW735_RS09185	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CW735_RS09190	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CW735_RS09195	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CW735_RS09200	COG0539	negative regulation of cytoplasmic translation
CW735_RS09205	COG0776	regulation of translation
CW735_RS09225	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CW735_RS09230	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CW735_RS09235	COG0284	orotidine-5'-phosphate decarboxylase activity
CW735_RS09240	COG0686	Belongs to the AlaDH PNT family
CW735_RS09250	COG1674	ftsk spoiiie
CW735_RS09250	COG0531	amino acid
CW735_RS09255	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CW735_RS09260	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CW735_RS09285	COG3447	MASE1 domain protein
CW735_RS09285	COG5002	protein histidine kinase activity
CW735_RS09285	COG5001	Diguanylate cyclase
CW735_RS09295	COG0840	transmembrane signaling receptor activity
CW735_RS09300	COG4191	Histidine kinase
CW735_RS09415	COG2920	part of a sulfur-relay system
CW735_RS09430	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CW735_RS09435	COG0670	Belongs to the BI1 family
CW735_RS09450	COG0583	DNA-binding transcription factor activity
CW735_RS09455	COG2259	Doxx family
CW735_RS09480	COG2197	response regulator
CW735_RS09485	COG0322	excinuclease ABC activity
CW735_RS09520	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CW735_RS09525	COG3148	PFAM DTW domain containing protein
CW735_RS09530	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CW735_RS09535	COG2897	thiosulfate sulfurtransferase activity
CW735_RS09545	COG1280	lysine exporter protein (LysE YggA)
CW735_RS09565	COG1752	Esterase of the alpha-beta hydrolase superfamily
CW735_RS09570	COG0037	tRNA processing
CW735_RS09575	COG0589	response to stress
CW735_RS09605	COG2010	Cytochrome c
CW735_RS09620	COG3278	Belongs to the heme-copper respiratory oxidase family
CW735_RS09635	COG2193	ferroxidase activity
CW735_RS09645	COG4651	solute:proton antiporter activity
CW735_RS09645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CW735_RS09650	COG0069	glutamate synthase activity
CW735_RS09660	COG0589	response to stress
CW735_RS09710	COG5433	transposase activity
CW735_RS09715	COG3039	Transposase
CW735_RS09740	COG2201	protein-glutamate methylesterase activity
CW735_RS09790	COG4774	siderophore transport
CW735_RS09870	COG4783	chaperone-mediated protein folding
CW735_RS09880	COG1393	Belongs to the ArsC family
CW735_RS09895	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CW735_RS09910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CW735_RS09920	COG1960	acyl-CoA dehydrogenase activity
CW735_RS09940	COG0572	uridine kinase
CW735_RS09945	COG3769	mannosylglycerate metabolic process
CW735_RS09950	COG1215	transferase activity, transferring glycosyl groups
CW735_RS09970	COG0303	'Molybdopterin
CW735_RS09975	COG0534	Mate efflux family protein
CW735_RS09985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CW735_RS09990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CW735_RS10010	COG0724	RNA recognition motif
CW735_RS10015	COG0384	phenazine biosynthesis protein PhzF
CW735_RS10020	COG0612	Peptidase, M16
CW735_RS10040	COG1185	polyribonucleotide nucleotidyltransferase activity
CW735_RS10055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CW735_RS10060	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CW735_RS10065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CW735_RS10080	COG0561	phosphatase activity
CW735_RS10085	COG1028	Short-chain dehydrogenase reductase Sdr
CW735_RS10095	COG1803	Methylglyoxal synthase
CW735_RS10095	COG1597	lipid kinase activity
CW735_RS10115	COG3300	MHYT domain
CW735_RS10115	COG5001	Diguanylate cyclase
CW735_RS10135	COG0149	triose-phosphate isomerase activity
CW735_RS10140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CW735_RS10145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CW735_RS10150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CW735_RS10155	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CW735_RS10160	COG1534	Rna-binding protein
CW735_RS10170	COG1067	ATP-dependent peptidase activity
CW735_RS10175	COG0495	leucyl-tRNA aminoacylation
CW735_RS10190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CW735_RS10195	COG0799	negative regulation of ribosome biogenesis
CW735_RS10200	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CW735_RS10205	COG0768	penicillin binding
CW735_RS10210	COG0772	Belongs to the SEDS family
CW735_RS10215	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CW735_RS10220	COG1686	Belongs to the peptidase S11 family
CW735_RS10225	COG2921	Belongs to the UPF0250 family
CW735_RS10230	COG0321	lipoyl(octanoyl) transferase activity
CW735_RS10235	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CW735_RS10255	COG0252	asparaginase activity
CW735_RS10265	COG0778	Nitroreductase
CW735_RS10280	COG0616	signal peptide processing
CW735_RS10285	COG3091	SprT-like family
CW735_RS10290	COG3092	negative regulation of chromosome organization
CW735_RS10295	COG0492	ferredoxin-NADP+ reductase activity
CW735_RS10300	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CW735_RS10305	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CW735_RS10310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CW735_RS10315	COG0542	response to heat
CW735_RS10320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CW735_RS10325	COG1278	Cold shock
CW735_RS10340	COG1187	pseudouridine synthase activity
CW735_RS10345	COG0482	sulfurtransferase activity
CW735_RS10350	COG2915	High frequency lysogenization protein hflD homolog
CW735_RS10355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CW735_RS10360	COG2850	peptidyl-arginine hydroxylation
CW735_RS10375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CW735_RS10375	COG0574	Belongs to the PEP-utilizing enzyme family
CW735_RS10385	COG0457	Tetratricopeptide repeat
CW735_RS10390	COG4771	TonB-dependent receptor
CW735_RS10395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CW735_RS10405	COG2914	Belongs to the UPF0125 (RnfH) family
CW735_RS10410	COG2867	negative regulation of translational initiation
CW735_RS10420	COG1902	pentaerythritol trinitrate reductase activity
CW735_RS10430	COG0582	viral genome integration into host DNA
CW735_RS10445	COG4584	PFAM Integrase catalytic
CW735_RS10450	COG1484	DNA-dependent DNA replication
CW735_RS10510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CW735_RS10515	COG2814	Major facilitator Superfamily
CW735_RS10520	COG4771	TonB-dependent receptor
CW735_RS10525	COG5001	Diguanylate cyclase
CW735_RS10525	COG3706	GGDEF domain
CW735_RS10525	COG4251	negative regulation of phosphorylation
CW735_RS10525	COG2203	Gaf domain
CW735_RS10535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CW735_RS10540	COG4136	ATPase activity
CW735_RS10550	COG4134	Bacterial extracellular solute-binding protein
CW735_RS10560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CW735_RS10580	COG1032	radical SAM domain protein
CW735_RS10615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CW735_RS10650	COG0501	Belongs to the peptidase M48B family
CW735_RS10695	COG3153	acetyltransferase
CW735_RS10695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CW735_RS10715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CW735_RS10730	COG0195	Participates in both transcription termination and antitermination
CW735_RS10740	COG3437	response regulator, receiver
CW735_RS10745	COG0784	Response regulator, receiver
CW735_RS10745	COG2198	Histidine kinase
CW735_RS10745	COG2205	protein histidine kinase activity
CW735_RS10750	COG4584	PFAM Integrase catalytic
CW735_RS10755	COG1484	DNA-dependent DNA replication
CW735_RS10780	COG4771	TonB-dependent receptor
CW735_RS10810	COG0596	Alpha beta hydrolase
CW735_RS10820	COG1960	acyl-CoA dehydrogenase activity
CW735_RS10825	COG0183	Belongs to the thiolase family
CW735_RS10830	COG1024	Enoyl-CoA hydratase
CW735_RS10830	COG1250	3-hydroxyacyl-CoA dehydrogenase
CW735_RS10835	COG0596	Alpha beta hydrolase
CW735_RS10850	COG0604	alcohol dehydrogenase
CW735_RS10885	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CW735_RS10905	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CW735_RS10915	COG0521	Mo-molybdopterin cofactor biosynthetic process
CW735_RS10920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CW735_RS10970	COG0436	Aminotransferase
CW735_RS10975	COG3268	Saccharopine dehydrogenase
CW735_RS10980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CW735_RS11005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CW735_RS11010	COG1074	ATP-dependent DNA helicase activity
CW735_RS11015	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CW735_RS11030	COG1022	Amp-dependent synthetase and ligase
CW735_RS11035	COG5001	Diguanylate cyclase
CW735_RS11035	COG3300	MHYT domain
CW735_RS11075	COG0583	DNA-binding transcription factor activity
CW735_RS11080	COG2204	response regulator
CW735_RS11090	COG4251	negative regulation of phosphorylation
CW735_RS11095	COG0784	Response regulator, receiver
CW735_RS11100	COG2205	protein histidine kinase activity
CW735_RS11100	COG0784	Response regulator, receiver
CW735_RS11130	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CW735_RS11155	COG3139	Protein of unknown function (DUF1315)
CW735_RS11165	COG1115	amino acid carrier protein
CW735_RS11170	COG2866	Carboxypeptidase
CW735_RS11190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CW735_RS11200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CW735_RS11205	COG1640	4-alpha-glucanotransferase
CW735_RS11215	COG0676	glucose-6-phosphate 1-epimerase activity
CW735_RS11220	COG0800	Aldolase
CW735_RS11230	COG0129	dihydroxy-acid dehydratase activity
CW735_RS11240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CW735_RS11245	COG1737	Transcriptional regulator
CW735_RS11250	COG0469	pyruvate kinase activity
CW735_RS11255	COG3344	reverse transcriptase
CW735_RS11270	COG3344	reverse transcriptase
CW735_RS11275	COG3153	acetyltransferase
CW735_RS11285	COG3547	Transposase (IS116 IS110 IS902 family)
CW735_RS11345	COG1671	Belongs to the UPF0178 family
CW735_RS11350	COG1028	Short-chain dehydrogenase reductase Sdr
CW735_RS11355	COG1028	Short-chain dehydrogenase reductase Sdr
CW735_RS11360	COG2130	NADP-dependent
CW735_RS11365	COG1960	acyl-CoA dehydrogenase activity
CW735_RS11370	COG0662	Cupin 2, conserved barrel domain protein
CW735_RS11370	COG2207	Transcriptional regulator
CW735_RS11425	COG0596	Alpha beta hydrolase
CW735_RS11435	COG0716	FMN binding
CW735_RS11445	COG0735	belongs to the Fur family
CW735_RS11455	COG1984	allophanate hydrolase subunit 2
CW735_RS11465	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CW735_RS11470	COG2996	Protein conserved in bacteria
CW735_RS11475	COG1765	OsmC-like protein
CW735_RS11480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CW735_RS11505	COG0436	Aminotransferase
CW735_RS11510	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CW735_RS11515	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CW735_RS11530	COG1238	metal cluster binding
CW735_RS11560	COG0702	epimerase
CW735_RS11570	COG0084	hydrolase, TatD family'
CW735_RS11585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CW735_RS11590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CW735_RS11595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CW735_RS11600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CW735_RS11615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CW735_RS11620	COG0416	fatty acid biosynthetic process
CW735_RS11630	COG1399	metal-binding, possibly nucleic acid-binding protein
CW735_RS11650	COG1530	ribonuclease E activity
CW735_RS11665	COG5002	protein histidine kinase activity
CW735_RS11675	COG4771	TonB-dependent receptor
CW735_RS11685	COG2207	Transcriptional regulator
CW735_RS11685	COG3708	Transcriptional regulator
CW735_RS11690	COG2153	protein acetylation
CW735_RS11700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CW735_RS11705	COG3724	N-succinylarginine dihydrolase activity
CW735_RS11720	COG1301	dicarboxylic acid transport
CW735_RS11725	COG4591	ABC-type transport system involved in lipoprotein release permease component
CW735_RS11730	COG1136	(ABC) transporter
CW735_RS11735	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CW735_RS11770	COG0328	RNA-DNA hybrid ribonuclease activity
CW735_RS11775	COG3321	synthase
CW735_RS11775	COG0604	alcohol dehydrogenase
CW735_RS11795	COG1643	Atp-dependent helicase
CW735_RS11810	COG2925	Exonuclease
CW735_RS11835	COG0183	Belongs to the thiolase family
CW735_RS11840	COG0789	Transcriptional regulator
CW735_RS11845	COG1960	acyl-CoA dehydrogenase activity
CW735_RS11850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CW735_RS11860	COG4770	biotin carboxylase activity
CW735_RS11900	COG2814	Major facilitator Superfamily
CW735_RS11960	COG4591	ABC-type transport system involved in lipoprotein release permease component
CW735_RS11970	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CW735_RS11980	COG2096	Adenosyltransferase
CW735_RS12015	COG1472	Belongs to the glycosyl hydrolase 3 family
CW735_RS12040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CW735_RS12040	COG0072	phenylalanine-tRNA ligase activity
CW735_RS12060	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CW735_RS12070	COG3001	Fructosamine kinase
CW735_RS12090	COG0154	amidase activity
CW735_RS12100	COG0730	response to heat
CW735_RS12105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CW735_RS12120	COG2233	PERMEase
CW735_RS12135	COG0784	Response regulator, receiver
CW735_RS12135	COG2205	protein histidine kinase activity
CW735_RS12140	COG2203	Gaf domain
CW735_RS12140	COG3706	GGDEF domain
CW735_RS12140	COG4251	negative regulation of phosphorylation
CW735_RS12140	COG5001	Diguanylate cyclase
CW735_RS12150	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CW735_RS12155	COG2252	PERMEase
CW735_RS12170	COG1309	transcriptional regulator
CW735_RS12180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CW735_RS12195	COG2351	hydroxyisourate hydrolase activity
CW735_RS12200	COG0402	S-adenosylhomocysteine deaminase activity
CW735_RS12210	COG5002	protein histidine kinase activity
CW735_RS12210	COG3447	MASE1 domain protein
CW735_RS12210	COG5001	Diguanylate cyclase
CW735_RS12220	COG0475	glutathione-regulated potassium exporter activity
CW735_RS12220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CW735_RS12235	COG1473	amidohydrolase
CW735_RS12245	COG0745	RESPONSE REGULATOR receiver
CW735_RS12255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CW735_RS12260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CW735_RS12380	COG1846	Transcriptional regulator
CW735_RS12385	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CW735_RS12410	COG1393	Belongs to the ArsC family
CW735_RS12420	COG1876	peptidase activity
CW735_RS12440	COG2988	succinylglutamate desuccinylase activity
CW735_RS12450	COG0330	HflC and HflK could
CW735_RS12460	COG0058	SHG alpha-glucan phosphorylase activity
CW735_RS12465	COG0033	Phosphoglucomutase
CW735_RS12470	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CW735_RS12475	COG0714	Associated with various cellular activities
CW735_RS12500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CW735_RS12510	COG2363	Small membrane protein
CW735_RS12520	COG0583	DNA-binding transcription factor activity
CW735_RS12530	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CW735_RS12540	COG3437	response regulator, receiver
CW735_RS12540	COG0784	Response regulator, receiver
CW735_RS12545	COG2890	protein-(glutamine-N5) methyltransferase activity
CW735_RS12555	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CW735_RS12560	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CW735_RS12565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CW735_RS12575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CW735_RS12580	COG2267	carboxylic ester hydrolase activity
CW735_RS12585	COG1064	alcohol dehydrogenase
CW735_RS12595	COG1064	alcohol dehydrogenase
CW735_RS12610	COG0012	GTP binding
CW735_RS12655	COG1115	amino acid carrier protein
CW735_RS12675	COG1199	ATP-dependent helicase activity
CW735_RS12710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CW735_RS12715	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CW735_RS12720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CW735_RS12725	COG0131	Imidazoleglycerol-phosphate dehydratase
CW735_RS12725	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CW735_RS12730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CW735_RS12760	COG0326	Molecular chaperone. Has ATPase activity
CW735_RS12765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CW735_RS12785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CW735_RS12795	COG3220	belongs to the UPF0276 family
CW735_RS12855	COG1183	phosphatidylcholine synthase activity
CW735_RS12875	COG0277	FAD linked oxidase domain protein
CW735_RS12895	COG0542	response to heat
CW735_RS12905	COG0564	pseudouridine synthase activity
CW735_RS12920	COG1595	DNA-templated transcription, initiation
CW735_RS12935	COG4221	oxidoreductase activity
CW735_RS12940	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CW735_RS12950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CW735_RS12960	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CW735_RS12970	COG0142	geranyltranstransferase activity
CW735_RS12980	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CW735_RS12985	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CW735_RS12995	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CW735_RS13010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CW735_RS13010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CW735_RS13025	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CW735_RS13030	COG0488	(ABC) transporter
CW735_RS13040	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CW735_RS13050	COG0560	Phosphoserine phosphatase
CW735_RS13060	COG0084	hydrolase, TatD family'
CW735_RS13095	COG3026	antisigma factor binding
CW735_RS13105	COG1595	DNA-templated transcription, initiation
CW735_RS13110	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CW735_RS13120	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CW735_RS13160	COG4795	General secretion pathway protein
CW735_RS13205	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CW735_RS13210	COG1047	Peptidyl-prolyl cis-trans
CW735_RS13220	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CW735_RS13225	COG0196	riboflavin kinase activity
CW735_RS13230	COG0728	peptidoglycan biosynthetic process
CW735_RS13235	COG0268	Binds directly to 16S ribosomal RNA
CW735_RS13265	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CW735_RS13275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CW735_RS13280	COG0776	regulation of translation
CW735_RS13285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CW735_RS13290	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CW735_RS13295	COG0740	serine-type endopeptidase activity
CW735_RS13300	COG0544	peptidyl-prolyl cis-trans isomerase activity
CW735_RS13340	COG1720	tRNA m6t6A37 methyltransferase activity
CW735_RS13350	COG1234	tRNA 3'-trailer cleavage
CW735_RS13360	COG0123	including yeast histone deacetylase and acetoin utilization protein
CW735_RS13380	COG0516	GMP reductase activity
CW735_RS13380	COG0517	IMP dehydrogenase activity
CW735_RS13385	COG1570	exodeoxyribonuclease VII activity
CW735_RS13400	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CW735_RS13405	COG2976	Protein conserved in bacteria
CW735_RS13425	COG3063	Type IV pilus biogenesis stability protein PilW
CW735_RS13430	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CW735_RS13440	COG2166	iron-sulfur cluster assembly
CW735_RS13450	COG0316	Belongs to the HesB IscA family
CW735_RS13455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CW735_RS13460	COG0719	Fe-S assembly protein
CW735_RS13465	COG0396	ATPase activity
CW735_RS13470	COG0719	Fe-S assembly protein
CW735_RS13475	COG1104	cysteine desulfurase activity
CW735_RS13480	COG1959	2 iron, 2 sulfur cluster binding
CW735_RS13500	COG2072	flavoprotein involved in K transport
CW735_RS13510	COG1045	serine acetyltransferase
CW735_RS13515	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CW735_RS13520	COG0483	inositol monophosphate 1-phosphatase activity
CW735_RS13525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CW735_RS13530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CW735_RS13535	COG1862	Preprotein translocase
CW735_RS13540	COG0343	queuine tRNA-ribosyltransferase activity
CW735_RS13560	COG1842	Phage shock protein A
CW735_RS13565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CW735_RS13585	COG0754	glutathionylspermidine amidase activity
CW735_RS13600	COG1136	(ABC) transporter
CW735_RS13620	COG2066	Belongs to the glutaminase family
CW735_RS13625	COG1785	Belongs to the alkaline phosphatase family
CW735_RS13630	COG0745	RESPONSE REGULATOR receiver
CW735_RS13720	COG0110	maltose O-acetyltransferase activity
CW735_RS13740	COG0438	transferase activity, transferring glycosyl groups
CW735_RS13755	COG0367	asparagine synthase
CW735_RS13765	COG0438	transferase activity, transferring glycosyl groups
CW735_RS13805	COG1216	Glycosyl transferase, family 2
CW735_RS13805	COG0463	Glycosyl transferase, family 2
CW735_RS13820	COG2244	polysaccharide biosynthetic process
CW735_RS13855	COG0489	protein tyrosine kinase activity
CW735_RS13865	COG3267	Type II secretory pathway component ExeA
CW735_RS13865	COG3409	Peptidoglycan-binding domain 1 protein
CW735_RS13870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CW735_RS13870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CW735_RS13895	COG1560	Kdo2-lipid A biosynthetic process
CW735_RS13925	COG1960	acyl-CoA dehydrogenase activity
CW735_RS13945	COG1435	thymidine kinase activity
CW735_RS13950	COG1609	Transcriptional regulator
CW735_RS13955	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CW735_RS13970	COG0675	Transposase, IS605 OrfB family
CW735_RS13985	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CW735_RS13990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CW735_RS14010	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CW735_RS14045	COG1960	acyl-CoA dehydrogenase activity
CW735_RS14085	COG4221	oxidoreductase activity
CW735_RS14090	COG1280	lysine exporter protein (LysE YggA)
CW735_RS14120	COG1028	Short-chain dehydrogenase reductase Sdr
CW735_RS14180	COG4558	Periplasmic binding protein
CW735_RS14185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CW735_RS14190	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CW735_RS14225	COG0514	ATP-dependent DNA helicase (RecQ)
CW735_RS14230	COG1295	ribonuclease BN
CW735_RS14235	COG4999	Histidine kinase
CW735_RS14235	COG3850	Histidine kinase
CW735_RS14235	COG3437	response regulator, receiver
CW735_RS14235	COG2205	protein histidine kinase activity
CW735_RS14265	COG2133	pyrroloquinoline quinone binding
CW735_RS14270	COG0513	Belongs to the DEAD box helicase family
CW735_RS14300	COG3177	Filamentation induced by cAMP protein fic
CW735_RS14305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CW735_RS14310	COG1518	maintenance of DNA repeat elements
CW735_RS14345	COG1203	CRISPR-associated helicase, Cas3
CW735_RS14355	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CW735_RS14355	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CW735_RS14390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CW735_RS14395	COG0583	DNA-binding transcription factor activity
CW735_RS14405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CW735_RS14410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CW735_RS14415	COG0006	proline dipeptidase activity
CW735_RS14420	COG3079	Belongs to the UPF0149 family
CW735_RS14430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CW735_RS14440	COG0784	Response regulator, receiver
CW735_RS14440	COG2205	protein histidine kinase activity
CW735_RS14445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CW735_RS14450	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CW735_RS14455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CW735_RS14510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CW735_RS14515	COG0508	dehydrogenase complex catalyzes the overall conversion of
CW735_RS14520	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CW735_RS14535	COG3023	N-Acetylmuramoyl-L-alanine amidase
CW735_RS14540	COG3577	Aspartyl protease
CW735_RS14545	COG0157	Belongs to the NadC ModD family
CW735_RS14555	COG1459	type II secretion system
CW735_RS14565	COG0237	dephospho-CoA kinase activity
CW735_RS14570	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CW735_RS14575	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CW735_RS14580	COG3608	succinylglutamate desuccinylase aspartoacylase
CW735_RS14585	COG0494	nUDIX hydrolase
CW735_RS14595	COG0739	heme binding
CW735_RS14600	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CW735_RS14605	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CW735_RS14610	COG0849	cell division
CW735_RS14615	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CW735_RS14620	COG1181	Belongs to the D-alanine--D-alanine ligase family
CW735_RS14625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CW735_RS14635	COG0772	Belongs to the SEDS family
CW735_RS14640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CW735_RS14650	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CW735_RS14655	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CW735_RS14660	COG0768	penicillin binding
CW735_RS14665	COG3116	cell division
CW735_RS14675	COG2001	Belongs to the MraZ family
CW735_RS14695	COG0678	peroxiredoxin activity
CW735_RS14695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CW735_RS14725	COG2204	response regulator
CW735_RS14730	COG5002	protein histidine kinase activity
CW735_RS14755	COG0668	transmembrane transport
CW735_RS14765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CW735_RS14770	COG0189	ligase activity
CW735_RS14775	COG1678	Uncharacterized ACR, COG1678
CW735_RS14780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CW735_RS14800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CW735_RS14805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CW735_RS14810	COG0762	integral membrane protein
CW735_RS14820	COG1902	pentaerythritol trinitrate reductase activity
CW735_RS14820	COG0446	pyridine nucleotide-disulphide oxidoreductase
CW735_RS14870	COG0083	homoserine kinase activity
CW735_RS14880	COG0583	DNA-binding transcription factor activity
CW735_RS14895	COG0640	Transcriptional regulator
CW735_RS14905	COG0431	NADPH-dependent FMN reductase
CW735_RS14910	COG0798	PFAM Bile acid sodium symporter
CW735_RS14920	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CW735_RS14925	COG0745	RESPONSE REGULATOR receiver
CW735_RS14935	COG1971	Probably functions as a manganese efflux pump
CW735_RS14960	COG1748	Saccharopine dehydrogenase
CW735_RS14975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CW735_RS14980	COG3107	peptidoglycan biosynthetic process
CW735_RS14985	COG0792	nuclease activity
CW735_RS14995	COG2823	Periplasmic or secreted lipoprotein
CW735_RS15025	COG2212	antiporter activity
CW735_RS15030	COG1863	multisubunit Na H antiporter MnhE subunit
CW735_RS15035	COG0651	ATP synthesis coupled electron transport
CW735_RS15040	COG1006	Multisubunit Na H antiporter MnhC subunit
CW735_RS15045	COG2111	Na H antiporter
CW735_RS15045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CW735_RS15060	COG4771	TonB-dependent receptor
CW735_RS15070	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CW735_RS15075	COG0372	Belongs to the citrate synthase family
CW735_RS15080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CW735_RS15085	COG2828	Protein conserved in bacteria
CW735_RS15090	COG2203	Gaf domain
CW735_RS15090	COG2199	diguanylate cyclase activity
CW735_RS15110	COG0784	Response regulator, receiver
CW735_RS15110	COG2198	Histidine kinase
CW735_RS15110	COG5002	protein histidine kinase activity
CW735_RS15115	COG3023	N-Acetylmuramoyl-L-alanine amidase
CW735_RS15120	COG0070	glutamate synthase
CW735_RS15120	COG0069	glutamate synthase activity
CW735_RS15120	COG0067	glutamate synthase
CW735_RS15125	COG0493	'glutamate synthase
CW735_RS15135	COG0154	amidase activity
CW735_RS15145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CW735_RS15155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CW735_RS15160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CW735_RS15175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CW735_RS15180	COG0739	heme binding
CW735_RS15185	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CW735_RS15195	COG4572	Cation transport regulator
CW735_RS15210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CW735_RS15215	COG0625	glutathione transferase activity
CW735_RS15225	COG3290	protein histidine kinase activity
CW735_RS15235	COG2894	cell division
CW735_RS15240	COG0850	regulation of cytokinetic process
CW735_RS15265	COG1981	membrane
CW735_RS15280	COG1914	H( )-stimulated, divalent metal cation uptake system
CW735_RS15285	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CW735_RS15295	COG1217	gtp-binding protein TYPA
CW735_RS15300	COG0174	glutamine synthetase
CW735_RS15310	COG3852	Histidine kinase
CW735_RS15315	COG2204	response regulator
CW735_RS15320	COG3437	response regulator, receiver
CW735_RS15350	COG0525	valine-tRNA ligase activity
CW735_RS15355	COG2927	DNA polymerase III (CHI subunit)
CW735_RS15360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CW735_RS15365	COG0795	lipopolysaccharide-transporting ATPase activity
CW735_RS15370	COG0795	lipopolysaccharide-transporting ATPase activity
CW735_RS15415	COG0738	Major facilitator superfamily
CW735_RS15435	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CW735_RS15445	COG0464	growth
CW735_RS15450	COG1404	Belongs to the peptidase S8 family
CW735_RS15460	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CW735_RS15465	COG0732	type I restriction modification DNA specificity domain
CW735_RS15470	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CW735_RS15505	COG0328	RNA-DNA hybrid ribonuclease activity
CW735_RS15505	COG3341	Caulimovirus viroplasmin
CW735_RS15520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CW735_RS15600	COG1484	DNA-dependent DNA replication
CW735_RS15605	COG4584	PFAM Integrase catalytic
CW735_RS15730	COG2199	diguanylate cyclase activity
CW735_RS15760	COG0425	Belongs to the sulfur carrier protein TusA family
CW735_RS15760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CW735_RS15795	COG3268	Saccharopine dehydrogenase
CW735_RS15800	COG1960	acyl-CoA dehydrogenase activity
CW735_RS15830	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CW735_RS15835	COG3706	GGDEF domain
CW735_RS15885	COG0277	FAD linked oxidase domain protein
CW735_RS15895	COG0513	Belongs to the DEAD box helicase family
CW735_RS15905	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CW735_RS15905	COG3264	Mechanosensitive ion channel
CW735_RS15945	COG0583	DNA-binding transcription factor activity
CW735_RS15950	COG0730	response to heat
CW735_RS15955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CW735_RS15960	COG0745	RESPONSE REGULATOR receiver
CW735_RS15970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CW735_RS15970	COG4191	Histidine kinase
CW735_RS16040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CW735_RS16050	COG1573	uracil-dna glycosylase
CW735_RS16055	COG3300	MHYT domain
CW735_RS16055	COG5001	Diguanylate cyclase
CW735_RS16075	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CW735_RS16100	COG1842	Phage shock protein A
CW735_RS16110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CW735_RS16115	COG0582	viral genome integration into host DNA
CW735_RS16185	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CW735_RS16200	COG3586	endonuclease activity
CW735_RS16250	COG3550	peptidyl-serine autophosphorylation
CW735_RS16270	COG0204	Acyl-transferase
CW735_RS16275	COG0204	Acyl-transferase
CW735_RS16280	COG0668	transmembrane transport
CW735_RS16295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CW735_RS16300	COG0733	neurotransmitter:sodium symporter activity
CW735_RS16315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW735_RS16330	COG0716	FMN binding
CW735_RS16340	COG0848	biopolymer transport protein
CW735_RS16355	COG0457	Tetratricopeptide repeat
CW735_RS16360	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CW735_RS16385	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CW735_RS16405	COG5002	protein histidine kinase activity
CW735_RS16405	COG5001	Diguanylate cyclase
CW735_RS16415	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CW735_RS16425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CW735_RS16435	COG0583	DNA-binding transcription factor activity
CW735_RS16440	COG0121	glutamine amidotransferase
CW735_RS16445	COG4628	conserved protein (DUF2132)
CW735_RS16470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CW735_RS16480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CW735_RS16490	COG1477	protein flavinylation
CW735_RS16495	COG2871	sodium ion transport
CW735_RS16500	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CW735_RS16505	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CW735_RS16510	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CW735_RS16515	COG1805	sodium ion transport
CW735_RS16520	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CW735_RS16530	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CW735_RS16535	COG0545	Peptidyl-prolyl cis-trans isomerase
CW735_RS16540	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CW735_RS16570	COG0039	L-malate dehydrogenase activity
CW735_RS16575	COG1438	arginine binding
CW735_RS16600	COG0572	uridine kinase
CW735_RS16605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CW735_RS16620	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CW735_RS16635	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CW735_RS16635	COG0517	IMP dehydrogenase activity
CW735_RS16640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CW735_RS16650	COG5002	protein histidine kinase activity
CW735_RS16660	COG0189	ligase activity
CW735_RS16670	COG0189	ligase activity
CW735_RS16670	COG4067	protein conserved in archaea
CW735_RS16685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CW735_RS16695	COG1283	sodium-dependent phosphate transmembrane transporter activity
CW735_RS16700	COG0667	Aldo Keto reductase
CW735_RS16710	COG5001	Diguanylate cyclase
CW735_RS16755	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CW735_RS16765	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CW735_RS16820	COG0583	DNA-binding transcription factor activity
CW735_RS16830	COG0675	Transposase, IS605 OrfB family
CW735_RS16855	COG2040	homocysteine
CW735_RS16875	COG1216	Glycosyl transferase, family 2
CW735_RS16875	COG0438	transferase activity, transferring glycosyl groups
CW735_RS16950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CW735_RS16965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CW735_RS16995	COG4372	Transposase
CW735_RS17010	COG1215	transferase activity, transferring glycosyl groups
CW735_RS17045	COG1083	cytidylyl-transferase
CW735_RS17060	COG2089	acid synthase
CW735_RS17065	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CW735_RS17070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CW735_RS17090	COG0662	Cupin 2, conserved barrel domain protein
CW735_RS17090	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CW735_RS17125	COG0202	RNA polymerase activity
CW735_RS17145	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CW735_RS17150	COG0201	protein transport
CW735_RS17155	COG0200	Binds to the 23S rRNA
CW735_RS17170	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CW735_RS17250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CW735_RS17255	COG0557	exoribonuclease II activity
CW735_RS17270	COG0675	Transposase, IS605 OrfB family
CW735_RS17280	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CW735_RS17300	COG2234	aminopeptidase activity
CW735_RS17310	COG4251	negative regulation of phosphorylation
CW735_RS17315	COG2814	Major facilitator Superfamily
CW735_RS17325	COG1271	oxidase subunit
CW735_RS17330	COG1294	oxidase, subunit
CW735_RS17335	COG1522	sequence-specific DNA binding
CW735_RS17345	COG1278	Cold shock
CW735_RS17350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CW735_RS17370	COG0339	signal peptide processing
CW735_RS17375	COG2201	protein-glutamate methylesterase activity
CW735_RS17385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CW735_RS17385	COG4191	Histidine kinase
CW735_RS17395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CW735_RS17400	COG2201	protein-glutamate methylesterase activity
CW735_RS17410	COG1506	peptidase
CW735_RS17410	COG4946	Tricorn protease homolog
CW735_RS17410	COG0823	Involved in the tonB-independent uptake of proteins
CW735_RS17465	COG2197	response regulator
CW735_RS17475	COG0189	ligase activity
CW735_RS17485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CW735_RS17490	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CW735_RS17495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CW735_RS17510	COG0281	malic enzyme
CW735_RS17520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CW735_RS17550	COG0456	acetyltransferase
CW735_RS17560	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CW735_RS17565	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CW735_RS17570	COG2177	Part of the ABC transporter FtsEX involved in
CW735_RS17575	COG2884	Cell division ATP-binding protein ftsE
CW735_RS17580	COG0552	protein localization to endoplasmic reticulum
CW735_RS17585	COG0742	ribosomal rna small subunit methyltransferase
CW735_RS17590	COG3068	Protein conserved in bacteria
CW735_RS17595	COG2095	MarC family integral membrane protein
CW735_RS17615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CW735_RS17620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CW735_RS17630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CW735_RS17645	COG0076	glutamate decarboxylase activity
CW735_RS17660	COG0842	Transport permease protein
CW735_RS17665	COG1131	(ABC) transporter
CW735_RS17690	COG1253	flavin adenine dinucleotide binding
CW735_RS17700	COG1966	Carbon starvation protein
CW735_RS17730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CW735_RS17735	COG0049	tRNA binding
CW735_RS17740	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CW735_RS17745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CW735_RS17750	COG0085	RNA polymerase activity
CW735_RS17755	COG0222	ribosome binding
CW735_RS17760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CW735_RS17765	COG0081	regulation of translation
CW735_RS17770	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CW735_RS17775	COG3706	GGDEF domain
CW735_RS17785	COG0250	Participates in transcription elongation, termination and antitermination
CW735_RS17790	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CW735_RS17800	COG1132	(ABC) transporter
CW735_RS17820	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CW735_RS17825	COG3590	peptidase
CW735_RS17835	COG0513	Belongs to the DEAD box helicase family
CW735_RS17840	COG0418	dihydroorotase activity
CW735_RS17850	COG3040	lipid binding
CW735_RS17855	COG4989	oxidoreductase activity
CW735_RS17860	COG0346	lactoylglutathione lyase activity
CW735_RS17880	COG0302	gtp cyclohydrolase
CW735_RS17890	COG2957	Belongs to the agmatine deiminase family
CW735_RS17895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CW735_RS17905	COG1201	RNA secondary structure unwinding
CW735_RS17925	COG1793	dna ligase
CW735_RS17950	COG0625	glutathione transferase activity
CW735_RS17965	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CW735_RS17980	COG1012	belongs to the aldehyde dehydrogenase family
CW735_RS17985	COG0028	Belongs to the TPP enzyme family
CW735_RS17995	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CW735_RS18000	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CW735_RS18005	COG0330	HflC and HflK could
CW735_RS18010	COG0330	HflC and HflK could
CW735_RS18015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CW735_RS18020	COG1923	regulation of RNA biosynthetic process
CW735_RS18025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CW735_RS18040	COG0802	atpase or kinase
CW735_RS18045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CW735_RS18045	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CW735_RS18065	COG2816	NAD+ diphosphatase activity
CW735_RS18070	COG0735	belongs to the Fur family
CW735_RS18080	COG0432	Pfam Uncharacterised protein family UPF0047
CW735_RS18090	COG0305	Participates in initiation and elongation during chromosome replication
CW735_RS18145	COG5002	protein histidine kinase activity
CW735_RS18155	COG1136	(ABC) transporter
CW735_RS18165	COG0840	transmembrane signaling receptor activity
CW735_RS18170	COG5002	protein histidine kinase activity
CW735_RS18195	COG1420	regulation of RNA biosynthetic process
CW735_RS18225	COG4774	siderophore transport
CW735_RS18230	COG1472	Belongs to the glycosyl hydrolase 3 family
CW735_RS18240	COG2723	6-phospho-beta-galactosidase activity
CW735_RS18245	COG1609	Transcriptional regulator
CW735_RS18250	COG0477	Major facilitator Superfamily
CW735_RS18250	COG2814	Major facilitator Superfamily
CW735_RS18255	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CW735_RS18260	COG4988	ABC transporter
CW735_RS18265	COG4890	Cyd operon protein YbgT
CW735_RS18270	COG1294	oxidase, subunit
CW735_RS18285	COG2204	response regulator
CW735_RS18300	COG2375	cellular response to nickel ion
CW735_RS18320	COG2267	carboxylic ester hydrolase activity
CW735_RS18330	COG3038	cytochrome b561
CW735_RS18335	COG2353	YceI-like domain
CW735_RS18340	COG1252	NADH dehydrogenase
CW735_RS18360	COG2067	long-chain fatty acid transport protein
CW735_RS18365	COG2203	Gaf domain
CW735_RS18365	COG3706	GGDEF domain
CW735_RS18365	COG5001	Diguanylate cyclase
CW735_RS18365	COG4251	negative regulation of phosphorylation
CW735_RS18380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CW735_RS18390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CW735_RS18400	COG0673	inositol 2-dehydrogenase activity
CW735_RS18415	COG0697	spore germination
CW735_RS18420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CW735_RS18425	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CW735_RS18435	COG1166	arginine decarboxylase activity
CW735_RS18445	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CW735_RS18465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CW735_RS18490	COG4232	protein-disulfide reductase activity
CW735_RS18500	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CW735_RS18505	COG0511	ligase activity, forming carbon-carbon bonds
CW735_RS18510	COG0439	Biotin carboxylase
CW735_RS18530	COG2176	DNA-directed DNA polymerase activity
CW735_RS18570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CW735_RS18575	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CW735_RS18595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CW735_RS18615	COG3093	addiction module antidote protein HigA
CW735_RS18650	COG3954	Phosphoribulokinase
CW735_RS18670	COG1501	Belongs to the glycosyl hydrolase 31 family
CW735_RS18675	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CW735_RS18680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CW735_RS18690	COG3031	protein transport across the cell outer membrane
CW735_RS18700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CW735_RS18705	COG1459	type II secretion system
CW735_RS18710	COG2165	general secretion pathway protein
CW735_RS18715	COG2165	general secretion pathway protein
CW735_RS18720	COG2165	general secretion pathway protein
CW735_RS18725	COG4795	General secretion pathway protein
CW735_RS18730	COG3156	type II secretion system protein K
CW735_RS18740	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CW735_RS18770	COG1012	belongs to the aldehyde dehydrogenase family
CW735_RS18780	COG1011	Hydrolase
CW735_RS18785	COG0494	nUDIX hydrolase
CW735_RS18790	COG1218	3'(2'),5'-bisphosphate nucleotidase
CW735_RS18800	COG2943	transferase activity, transferring hexosyl groups
CW735_RS18805	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CW735_RS18815	COG3089	Belongs to the UPF0270 family
CW735_RS18820	COG0429	hydrolase of the alpha beta-hydrolase fold
CW735_RS18830	COG0488	(ABC) transporter
CW735_RS18840	COG2900	Belongs to the SlyX family
CW735_RS18850	COG0545	Peptidyl-prolyl cis-trans isomerase
CW735_RS18865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CW735_RS18870	COG2183	response to ionizing radiation
CW735_RS18885	COG0596	Alpha beta hydrolase
CW735_RS18890	COG1040	competence protein
CW735_RS18910	COG1794	racemase activity, acting on amino acids and derivatives
CW735_RS18920	COG0534	Mate efflux family protein
CW735_RS18935	COG1999	signal sequence binding
CW735_RS18940	COG0109	protoheme IX farnesyltransferase activity
CW735_RS18945	COG1612	heme a metabolic process
CW735_RS18975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CW735_RS18980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CW735_RS19010	COG0129	dihydroxy-acid dehydratase activity
CW735_RS19015	COG2860	membrane
CW735_RS19020	COG0606	chelatase, subunit chli
CW735_RS19045	COG2814	Major facilitator Superfamily
CW735_RS19055	COG0729	surface antigen
CW735_RS19060	COG2911	Protein conserved in bacteria
CW735_RS19070	COG1595	DNA-templated transcription, initiation
CW735_RS19085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CW735_RS19095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CW735_RS19115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CW735_RS19140	COG1228	amidohydrolase
CW735_RS19155	COG0425	Belongs to the sulfur carrier protein TusA family
CW735_RS19170	COG1561	YicC-like family, N-terminal region
CW735_RS19185	COG3550	peptidyl-serine autophosphorylation
CW735_RS19190	COG3620	sequence-specific DNA binding
CW735_RS19240	COG1061	Type III restriction enzyme res subunit
CW735_RS19340	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CW735_RS19360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CW735_RS19365	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CW735_RS19385	COG1475	DNA binding
CW735_RS19390	COG1192	Involved in chromosome partitioning
CW735_RS19415	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CW735_RS19420	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CW735_RS19430	COG0706	membrane insertase activity
CW735_RS19435	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CW735_RS19440	COG0594	ribonuclease P activity
CW735_RS19445	COG0230	Belongs to the bacterial ribosomal protein bL34 family