locus-tag	class	description
AV939_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AV939_RS00020	COG0187	DNA topoisomerase II activity
AV939_RS00045	COG2818	Glycosylase
AV939_RS00055	COG3078	GTPase activator activity
AV939_RS00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AV939_RS00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AV939_RS00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AV939_RS00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AV939_RS00085	COG0569	domain protein
AV939_RS00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AV939_RS00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AV939_RS00110	COG0758	DNA mediated transformation
AV939_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
AV939_RS00130	COG0408	coproporphyrinogen oxidase activity
AV939_RS00135	COG3047	cAMP biosynthetic process
AV939_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AV939_RS00205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AV939_RS00225	COG2234	aminopeptidase activity
AV939_RS00240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AV939_RS00265	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AV939_RS00305	COG3642	lipopolysaccharide core region biosynthetic process
AV939_RS00310	COG0859	PFAM glycosyl transferase family 9
AV939_RS00330	COG0156	8-amino-7-oxononanoate synthase activity
AV939_RS00340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AV939_RS00345	COG0705	Rhomboid family
AV939_RS00355	COG3161	chorismate lyase activity
AV939_RS00360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AV939_RS00365	COG2960	long-chain fatty acid transporting porin activity
AV939_RS00370	COG0210	DNA helicase
AV939_RS00390	COG1757	Na H antiporter
AV939_RS00465	COG1620	l-lactate permease
AV939_RS00480	COG2181	nitrate reductase activity
AV939_RS00480	COG0247	lactate metabolic process
AV939_RS00485	COG0446	pyridine nucleotide-disulphide oxidoreductase
AV939_RS00485	COG1902	pentaerythritol trinitrate reductase activity
AV939_RS00505	COG4638	Rieske (2fe-2S)
AV939_RS00520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AV939_RS00560	COG1760	l-serine dehydratase
AV939_RS00565	COG0583	DNA-binding transcription factor activity
AV939_RS00580	COG1012	belongs to the aldehyde dehydrogenase family
AV939_RS00585	COG4948	Mandelate Racemase Muconate Lactonizing
AV939_RS00595	COG1012	belongs to the aldehyde dehydrogenase family
AV939_RS00600	COG4771	TonB-dependent receptor
AV939_RS00605	COG0457	Tetratricopeptide repeat
AV939_RS00610	COG4999	Histidine kinase
AV939_RS00610	COG3850	Histidine kinase
AV939_RS00610	COG3437	response regulator, receiver
AV939_RS00610	COG2205	protein histidine kinase activity
AV939_RS00615	COG4773	Receptor
AV939_RS00620	COG0583	DNA-binding transcription factor activity
AV939_RS00635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AV939_RS00640	COG1129	ABC transporter
AV939_RS00640	COG0842	Transport permease protein
AV939_RS00645	COG0842	Transport permease protein
AV939_RS00655	COG1960	acyl-CoA dehydrogenase activity
AV939_RS00660	COG0583	DNA-binding transcription factor activity
AV939_RS00675	COG3106	COG3106 Predicted ATPase
AV939_RS00695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AV939_RS00710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AV939_RS00725	COG4771	TonB-dependent receptor
AV939_RS00730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AV939_RS00740	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AV939_RS00740	COG0778	Nitroreductase
AV939_RS00750	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AV939_RS00755	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AV939_RS00760	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AV939_RS00765	COG1309	transcriptional regulator
AV939_RS00790	COG1953	Uracil, thiamine, allantoin
AV939_RS00800	COG3071	HemY protein
AV939_RS00805	COG2959	enzyme of heme biosynthesis
AV939_RS00815	COG0181	hydroxymethylbilane synthase activity
AV939_RS00830	COG0194	GDP metabolic process
AV939_RS00840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AV939_RS00850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AV939_RS00855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AV939_RS00865	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AV939_RS00865	COG0678	peroxiredoxin activity
AV939_RS00885	COG1178	ABC-type Fe3 transport system permease component
AV939_RS00890	COG3842	ATPase activity
AV939_RS00895	COG2081	HI0933 family
AV939_RS00900	COG0668	transmembrane transport
AV939_RS00925	COG5002	protein histidine kinase activity
AV939_RS00925	COG5001	Diguanylate cyclase
AV939_RS00925	COG3447	MASE1 domain protein
AV939_RS00935	COG0583	DNA-binding transcription factor activity
AV939_RS00960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AV939_RS00965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AV939_RS00975	COG0427	acetyl-CoA hydrolase
AV939_RS00980	COG0123	including yeast histone deacetylase and acetoin utilization protein
AV939_RS00990	COG0840	transmembrane signaling receptor activity
AV939_RS01000	COG3064	Membrane
AV939_RS01005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AV939_RS01010	COG5001	Diguanylate cyclase
AV939_RS01010	COG5002	protein histidine kinase activity
AV939_RS01020	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AV939_RS01030	COG0514	ATP-dependent DNA helicase (RecQ)
AV939_RS01035	COG2050	protein possibly involved in aromatic compounds catabolism
AV939_RS01040	COG2239	Acts as a magnesium transporter
AV939_RS01045	COG2962	Rard protein
AV939_RS01065	COG1011	Hydrolase
AV939_RS01080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AV939_RS01085	COG0019	diaminopimelate decarboxylase activity
AV939_RS01115	COG0163	prenyltransferase activity
AV939_RS01120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AV939_RS01130	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AV939_RS01155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AV939_RS01160	COG2814	Major facilitator Superfamily
AV939_RS01165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AV939_RS01185	COG1085	galactose-1-phosphate uridylyltransferase
AV939_RS01190	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AV939_RS01200	COG0629	single-stranded DNA binding
AV939_RS01240	COG3710	Transcriptional regulator
AV939_RS01250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AV939_RS01270	COG4615	Cyclic peptide transporter
AV939_RS01285	COG0745	RESPONSE REGULATOR receiver
AV939_RS01295	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AV939_RS01325	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AV939_RS01350	COG1349	DNA-binding transcription factor activity
AV939_RS01390	COG3267	Type II secretory pathway component ExeA
AV939_RS01390	COG3409	Peptidoglycan-binding domain 1 protein
AV939_RS01400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AV939_RS01405	COG1459	type II secretion system
AV939_RS01415	COG2165	general secretion pathway protein
AV939_RS01420	COG2165	general secretion pathway protein
AV939_RS01445	COG1077	Cell shape determining protein MreB Mrl
AV939_RS01450	COG1792	Involved in formation and maintenance of cell shape
AV939_RS01455	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AV939_RS01465	COG1530	ribonuclease E activity
AV939_RS01475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AV939_RS01480	COG0312	modulator of DNA gyrase
AV939_RS01490	COG3028	Belongs to the UPF0307 family
AV939_RS01495	COG0312	modulator of DNA gyrase
AV939_RS01510	COG0745	RESPONSE REGULATOR receiver
AV939_RS01515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AV939_RS01515	COG4191	Histidine kinase
AV939_RS01520	COG0297	glycogen (starch) synthase activity
AV939_RS01530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AV939_RS01540	COG1194	a g-specific adenine glycosylase
AV939_RS01595	COG0745	RESPONSE REGULATOR receiver
AV939_RS01600	COG0643	Histidine kinase
AV939_RS01600	COG2198	Histidine kinase
AV939_RS01605	COG0835	chemotaxis
AV939_RS01620	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AV939_RS01625	COG2201	protein-glutamate methylesterase activity
AV939_RS01640	COG0501	Belongs to the peptidase M48B family
AV939_RS01705	COG1609	Transcriptional regulator
AV939_RS01710	COG0673	inositol 2-dehydrogenase activity
AV939_RS01720	COG2211	Major facilitator Superfamily
AV939_RS01770	COG1454	alcohol dehydrogenase
AV939_RS01790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AV939_RS01795	COG0051	transcription antitermination factor activity, RNA binding
AV939_RS01810	COG0089	rRNA binding
AV939_RS01820	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AV939_RS01830	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AV939_RS01845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AV939_RS01850	COG0438	transferase activity, transferring glycosyl groups
AV939_RS01855	COG0859	PFAM glycosyl transferase family 9
AV939_RS01860	COG1519	Transferase
AV939_RS01885	COG0339	signal peptide processing
AV939_RS01895	COG0788	formyltetrahydrofolate deformylase activity
AV939_RS01905	COG1643	Atp-dependent helicase
AV939_RS01910	COG2951	lytic endotransglycosylase activity
AV939_RS01920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AV939_RS01930	COG2354	Protein conserved in bacteria
AV939_RS01955	COG0004	ammonium transporteR
AV939_RS01960	COG0405	Gamma-glutamyltransferase
AV939_RS01965	COG2837	iron assimilation
AV939_RS01980	COG0540	Belongs to the ATCase OTCase family
AV939_RS02005	COG0784	Response regulator, receiver
AV939_RS02005	COG2205	protein histidine kinase activity
AV939_RS02005	COG5002	protein histidine kinase activity
AV939_RS02030	COG1012	belongs to the aldehyde dehydrogenase family
AV939_RS02040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AV939_RS02050	COG0512	Glutamine amidotransferase of anthranilate synthase
AV939_RS02055	COG0180	Tryptophanyl-tRNA synthetase
AV939_RS02060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AV939_RS02080	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AV939_RS02090	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AV939_RS02125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AV939_RS02130	COG0281	malic enzyme
AV939_RS02135	COG0625	glutathione transferase activity
AV939_RS02170	COG5001	Diguanylate cyclase
AV939_RS02170	COG3300	MHYT domain
AV939_RS02175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AV939_RS02175	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AV939_RS02185	COG0137	argininosuccinate synthase activity
AV939_RS02190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AV939_RS02205	COG1803	Methylglyoxal synthase
AV939_RS02215	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AV939_RS02230	COG0745	RESPONSE REGULATOR receiver
AV939_RS02235	COG2205	protein histidine kinase activity
AV939_RS02240	COG2267	carboxylic ester hydrolase activity
AV939_RS02245	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AV939_RS02260	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AV939_RS02270	COG4942	peptidase
AV939_RS02280	COG2861	carbohydrate metabolic process
AV939_RS02290	COG0584	glycerophosphoryl diester phosphodiesterase
AV939_RS02305	COG1162	GTPase activity
AV939_RS02310	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AV939_RS02330	COG0457	Tetratricopeptide repeat
AV939_RS02345	COG0028	Belongs to the TPP enzyme family
AV939_RS02365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AV939_RS02370	COG0805	protein transport
AV939_RS02395	COG0248	Ppx GppA phosphatase
AV939_RS02400	COG0513	Belongs to the DEAD box helicase family
AV939_RS02405	COG3118	belongs to the thioredoxin family
AV939_RS02410	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AV939_RS02415	COG1473	amidohydrolase
AV939_RS02420	COG0784	Response regulator, receiver
AV939_RS02420	COG2205	protein histidine kinase activity
AV939_RS02425	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AV939_RS02430	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AV939_RS02435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AV939_RS02450	COG0783	Belongs to the Dps family
AV939_RS02455	COG2133	pyrroloquinoline quinone binding
AV939_RS02465	COG3118	belongs to the thioredoxin family
AV939_RS02475	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AV939_RS02485	COG1012	belongs to the aldehyde dehydrogenase family
AV939_RS02505	COG1757	Na H antiporter
AV939_RS02525	COG3876	Protein conserved in bacteria
AV939_RS02530	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AV939_RS02550	COG0346	lactoylglutathione lyase activity
AV939_RS02565	COG0840	transmembrane signaling receptor activity
AV939_RS02625	COG4115	mRNA cleavage
AV939_RS02630	COG2161	toxin-antitoxin pair type II binding
AV939_RS02730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AV939_RS02735	COG0666	response to abiotic stimulus
AV939_RS02805	COG0596	Alpha beta hydrolase
AV939_RS02810	COG1960	acyl-CoA dehydrogenase activity
AV939_RS02815	COG0183	Belongs to the thiolase family
AV939_RS02820	COG1250	3-hydroxyacyl-CoA dehydrogenase
AV939_RS02820	COG1024	Enoyl-CoA hydratase
AV939_RS02825	COG0596	Alpha beta hydrolase
AV939_RS02855	COG1960	acyl-CoA dehydrogenase activity
AV939_RS02865	COG4771	TonB-dependent receptor
AV939_RS02885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AV939_RS02905	COG0314	molybdopterin synthase activity
AV939_RS02910	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AV939_RS02915	COG0315	cyclic pyranopterin monophosphate synthase activity
AV939_RS02920	COG0521	Mo-molybdopterin cofactor biosynthetic process
AV939_RS02925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AV939_RS02990	COG0183	Belongs to the thiolase family
AV939_RS02995	COG1024	Enoyl-CoA hydratase
AV939_RS02995	COG1250	3-hydroxyacyl-CoA dehydrogenase
AV939_RS03005	COG0006	proline dipeptidase activity
AV939_RS03015	COG0142	geranyltranstransferase activity
AV939_RS03075	COG1238	metal cluster binding
AV939_RS03085	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AV939_RS03090	COG0585	pseudouridine synthase activity
AV939_RS03105	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AV939_RS03115	COG0840	transmembrane signaling receptor activity
AV939_RS03120	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AV939_RS03120	COG0506	proline dehydrogenase activity
AV939_RS03120	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AV939_RS03135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AV939_RS03150	COG4991	sh3 domain protein
AV939_RS03155	COG3025	triphosphatase activity
AV939_RS03170	COG0494	nUDIX hydrolase
AV939_RS03175	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
AV939_RS03180	COG0730	response to heat
AV939_RS03185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AV939_RS03190	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AV939_RS03195	COG2201	protein-glutamate methylesterase activity
AV939_RS03200	COG3706	GGDEF domain
AV939_RS03205	COG5002	protein histidine kinase activity
AV939_RS03205	COG0784	Response regulator, receiver
AV939_RS03225	COG0564	pseudouridine synthase activity
AV939_RS03235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AV939_RS03245	COG1802	Transcriptional regulator
AV939_RS03250	COG3119	arylsulfatase activity
AV939_RS03255	COG1012	belongs to the aldehyde dehydrogenase family
AV939_RS03260	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_RS03265	COG1063	alcohol dehydrogenase
AV939_RS03270	COG4948	Mandelate Racemase Muconate Lactonizing
AV939_RS03275	COG2814	Major facilitator Superfamily
AV939_RS03280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AV939_RS03295	COG2124	cytochrome p450
AV939_RS03395	COG3119	arylsulfatase activity
AV939_RS03430	COG3119	arylsulfatase activity
AV939_RS03435	COG3119	arylsulfatase activity
AV939_RS03445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AV939_RS03445	COG1648	precorrin-2 dehydrogenase activity
AV939_RS03465	COG1538	Outer membrane efflux protein
AV939_RS03470	COG0494	nUDIX hydrolase
AV939_RS03485	COG3150	esterase
AV939_RS03500	COG4251	negative regulation of phosphorylation
AV939_RS03505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AV939_RS03525	COG1509	lysine 2,3-aminomutase activity
AV939_RS03530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AV939_RS03555	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AV939_RS03570	COG0271	Belongs to the BolA IbaG family
AV939_RS03575	COG0671	phosphoesterase, PA-phosphatase related
AV939_RS03585	COG3707	response regulator
AV939_RS03595	COG0659	secondary active sulfate transmembrane transporter activity
AV939_RS03600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AV939_RS03605	COG2146	nitrite reductase [NAD(P)H] activity
AV939_RS03610	COG0243	molybdopterin cofactor binding
AV939_RS03615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AV939_RS03615	COG1648	precorrin-2 dehydrogenase activity
AV939_RS03630	COG1116	anion transmembrane transporter activity
AV939_RS03630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AV939_RS03635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AV939_RS03640	COG1116	anion transmembrane transporter activity
AV939_RS03655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AV939_RS03660	COG4206	TonB-dependent receptor
AV939_RS03665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AV939_RS03670	COG0348	domain, Protein
AV939_RS03685	COG1960	acyl-CoA dehydrogenase activity
AV939_RS03690	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_RS03710	COG4948	Mandelate Racemase Muconate Lactonizing
AV939_RS03725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AV939_RS03730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AV939_RS03755	COG0358	DNA primase activity
AV939_RS03760	COG1610	YqeY-like protein
AV939_RS03780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AV939_RS03785	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AV939_RS03800	COG0537	adenosine 5'-monophosphoramidase activity
AV939_RS03815	COG3135	benzoate transporter
AV939_RS03820	COG1396	sequence-specific DNA binding
AV939_RS03825	COG2974	May be involved in recombination
AV939_RS03830	COG4191	Histidine kinase
AV939_RS03830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AV939_RS03835	COG0745	RESPONSE REGULATOR receiver
AV939_RS03840	COG5002	protein histidine kinase activity
AV939_RS03870	COG0811	peptide transport
AV939_RS03875	COG0811	peptide transport
AV939_RS03880	COG0848	biopolymer transport protein
AV939_RS03885	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AV939_RS03895	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AV939_RS03900	COG3437	response regulator, receiver
AV939_RS03920	COG2133	pyrroloquinoline quinone binding
AV939_RS03925	COG1049	propionate catabolic process, 2-methylcitrate cycle
AV939_RS03945	COG0527	aspartate kinase activity
AV939_RS03950	COG0840	transmembrane signaling receptor activity
AV939_RS03955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AV939_RS03965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AV939_RS03970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AV939_RS03975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AV939_RS03980	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AV939_RS03985	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AV939_RS03995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AV939_RS04015	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AV939_RS04025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AV939_RS04030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AV939_RS04035	COG3956	TIGRFAM MazG family protein
AV939_RS04055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AV939_RS04060	COG1595	DNA-templated transcription, initiation
AV939_RS04070	COG4206	TonB-dependent receptor
AV939_RS04080	COG1473	amidohydrolase
AV939_RS04085	COG0723	plastoquinol--plastocyanin reductase activity
AV939_RS04090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AV939_RS04095	COG2857	Cytochrome c1
AV939_RS04100	COG0625	glutathione transferase activity
AV939_RS04105	COG2969	positive regulation of protein catabolic process
AV939_RS04110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV939_RS04110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV939_RS04115	COG2207	Transcriptional regulator
AV939_RS04115	COG3708	Transcriptional regulator
AV939_RS04125	COG2239	Acts as a magnesium transporter
AV939_RS04130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AV939_RS04150	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AV939_RS04155	COG1137	ATPase activity
AV939_RS04170	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AV939_RS04185	COG1127	ABC transporter
AV939_RS04190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AV939_RS04195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AV939_RS04200	COG2854	intermembrane phospholipid transfer
AV939_RS04210	COG5007	Belongs to the BolA IbaG family
AV939_RS04220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AV939_RS04225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AV939_RS04235	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AV939_RS04250	COG2207	Transcriptional regulator
AV939_RS04265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AV939_RS04280	COG5001	Diguanylate cyclase
AV939_RS04280	COG3300	MHYT domain
AV939_RS04285	COG0784	Response regulator, receiver
AV939_RS04285	COG2205	protein histidine kinase activity
AV939_RS04290	COG0683	leucine binding
AV939_RS04295	COG2207	Transcriptional regulator
AV939_RS04300	COG1979	alcohol dehydrogenase
AV939_RS04325	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AV939_RS04335	COG0126	phosphoglycerate kinase activity
AV939_RS04340	COG3588	fructose-bisphosphate aldolase
AV939_RS04345	COG4946	Tricorn protease homolog
AV939_RS04345	COG0823	Involved in the tonB-independent uptake of proteins
AV939_RS04345	COG1506	peptidase
AV939_RS04350	COG0248	Ppx GppA phosphatase
AV939_RS04355	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AV939_RS04365	COG0573	inorganic phosphate transmembrane transporter activity
AV939_RS04370	COG0581	inorganic phosphate transmembrane transporter activity
AV939_RS04375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AV939_RS04385	COG0306	phosphate transporter
AV939_RS04395	COG0583	DNA-binding transcription factor activity
AV939_RS04420	COG1272	protein, Hemolysin III
AV939_RS04440	COG0477	Major facilitator Superfamily
AV939_RS04445	COG1609	Transcriptional regulator
AV939_RS04445	COG2207	Transcriptional regulator
AV939_RS04450	COG1070	Carbohydrate kinase
AV939_RS04455	COG2115	Belongs to the xylose isomerase family
AV939_RS04460	COG3291	Pkd domain containing protein
AV939_RS04460	COG4447	cellulose binding
AV939_RS04460	COG5520	Belongs to the glycosyl hydrolase 30 family
AV939_RS04465	COG2207	Transcriptional regulator
AV939_RS04480	COG1472	Belongs to the glycosyl hydrolase 3 family
AV939_RS04485	COG1846	Transcriptional regulator
AV939_RS04490	COG1764	response to oxidative stress
AV939_RS04505	COG1739	Uncharacterized protein family UPF0029
AV939_RS04515	COG0420	3'-5' exonuclease activity
AV939_RS04520	COG0419	ATPase involved in DNA repair
AV939_RS04525	COG3706	GGDEF domain
AV939_RS04535	COG2971	BadF BadG BcrA BcrD
AV939_RS04540	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AV939_RS04545	COG1752	Esterase of the alpha-beta hydrolase superfamily
AV939_RS04550	COG0488	(ABC) transporter
AV939_RS04585	COG4667	esterase of the alpha-beta hydrolase superfamily
AV939_RS04655	COG1346	cytolysis
AV939_RS04685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AV939_RS04695	COG0513	Belongs to the DEAD box helicase family
AV939_RS04705	COG3409	Peptidoglycan-binding domain 1 protein
AV939_RS04705	COG3267	Type II secretory pathway component ExeA
AV939_RS04715	COG0784	Response regulator, receiver
AV939_RS04715	COG3437	response regulator, receiver
AV939_RS04720	COG0066	3-isopropylmalate dehydratase activity
AV939_RS04730	COG0473	3-isopropylmalate dehydrogenase activity
AV939_RS04735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AV939_RS04765	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AV939_RS04780	COG4555	ABC transporter
AV939_RS04785	COG1668	transmembrane transport
AV939_RS04805	COG4133	protoheme IX ABC transporter activity
AV939_RS04810	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AV939_RS04815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AV939_RS04820	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AV939_RS04830	COG1138	Cytochrome C-type biogenesis protein
AV939_RS04835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AV939_RS04850	COG2853	Lipoprotein
AV939_RS04855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AV939_RS04880	COG1682	transport, permease protein
AV939_RS04910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AV939_RS04915	COG1555	photosystem II stabilization
AV939_RS04915	COG1596	polysaccharide export
AV939_RS04920	COG0473	3-isopropylmalate dehydrogenase activity
AV939_RS04935	COG1611	Belongs to the LOG family
AV939_RS04945	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AV939_RS04945	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AV939_RS05015	COG0564	pseudouridine synthase activity
AV939_RS05030	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AV939_RS05035	COG0024	Methionine aminopeptidase
AV939_RS05040	COG0052	Belongs to the universal ribosomal protein uS2 family
AV939_RS05050	COG0528	UMP kinase activity
AV939_RS05060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AV939_RS05065	COG0575	Belongs to the CDS family
AV939_RS05070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AV939_RS05075	COG0750	zinc metalloprotease
AV939_RS05090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AV939_RS05095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AV939_RS05110	COG0587	DNA-directed DNA polymerase activity
AV939_RS05115	COG0825	malonyl-CoA metabolic process
AV939_RS05120	COG0037	tRNA processing
AV939_RS05150	COG0047	phosphoribosylformylglycinamidine synthase activity
AV939_RS05150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AV939_RS05155	COG2840	Smr protein MutS2
AV939_RS05180	COG3547	Transposase (IS116 IS110 IS902 family)
AV939_RS05185	COG0513	Belongs to the DEAD box helicase family
AV939_RS05190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AV939_RS05195	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AV939_RS05200	COG0583	DNA-binding transcription factor activity
AV939_RS05220	COG1760	l-serine dehydratase
AV939_RS05225	COG0494	nUDIX hydrolase
AV939_RS05230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AV939_RS05245	COG1404	Belongs to the peptidase S8 family
AV939_RS05250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AV939_RS05255	COG0022	dehydrogenase e1 component
AV939_RS05260	COG0508	dehydrogenase complex catalyzes the overall conversion of
AV939_RS05265	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AV939_RS05270	COG0515	serine threonine protein kinase
AV939_RS05275	COG1946	Acyl-CoA thioesterase
AV939_RS05285	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AV939_RS05295	COG1956	GAF domain-containing protein
AV939_RS05310	COG0793	Belongs to the peptidase S41A family
AV939_RS05315	COG0733	neurotransmitter:sodium symporter activity
AV939_RS05320	COG1757	Na H antiporter
AV939_RS05325	COG0308	aminopeptidase N
AV939_RS05355	COG2902	Dehydrogenase
AV939_RS05360	COG0167	dihydroorotate dehydrogenase activity
AV939_RS05375	COG0488	(ABC) transporter
AV939_RS05385	COG3130	regulation of translation
AV939_RS05390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AV939_RS05400	COG0415	Belongs to the DNA photolyase family
AV939_RS05405	COG0415	Belongs to the DNA photolyase family
AV939_RS05410	COG3046	protein related to deoxyribodipyrimidine photolyase
AV939_RS05435	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AV939_RS05440	COG0589	response to stress
AV939_RS05450	COG0069	glutamate synthase activity
AV939_RS05465	COG2193	ferroxidase activity
AV939_RS05475	COG3278	Belongs to the heme-copper respiratory oxidase family
AV939_RS05490	COG2010	Cytochrome c
AV939_RS05500	COG2217	Heavy metal translocating P-type atpase
AV939_RS05515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AV939_RS05525	COG0037	tRNA processing
AV939_RS05530	COG1752	Esterase of the alpha-beta hydrolase superfamily
AV939_RS05550	COG1280	lysine exporter protein (LysE YggA)
AV939_RS05560	COG2897	thiosulfate sulfurtransferase activity
AV939_RS05565	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AV939_RS05570	COG3148	PFAM DTW domain containing protein
AV939_RS05615	COG0322	excinuclease ABC activity
AV939_RS05620	COG2197	response regulator
AV939_RS05625	COG1741	Belongs to the pirin family
AV939_RS05635	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AV939_RS05655	COG0642	Histidine kinase
AV939_RS05660	COG0745	RESPONSE REGULATOR receiver
AV939_RS05685	COG0670	Belongs to the BI1 family
AV939_RS05695	COG2923	Belongs to the DsrF TusC family
AV939_RS05705	COG2920	part of a sulfur-relay system
AV939_RS05710	COG0561	phosphatase activity
AV939_RS05725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AV939_RS05730	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AV939_RS05735	COG1674	ftsk spoiiie
AV939_RS05735	COG0531	amino acid
AV939_RS05745	COG0686	Belongs to the AlaDH PNT family
AV939_RS05750	COG0284	orotidine-5'-phosphate decarboxylase activity
AV939_RS05755	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AV939_RS05760	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AV939_RS05770	COG0776	regulation of translation
AV939_RS05775	COG0539	negative regulation of cytoplasmic translation
AV939_RS05780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AV939_RS05785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AV939_RS05790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AV939_RS05805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AV939_RS05810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AV939_RS05815	COG0633	Ferredoxin
AV939_RS05820	COG5002	protein histidine kinase activity
AV939_RS05945	COG1131	(ABC) transporter
AV939_RS05980	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AV939_RS05985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AV939_RS05995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AV939_RS06005	COG4783	chaperone-mediated protein folding
AV939_RS06015	COG1393	Belongs to the ArsC family
AV939_RS06050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AV939_RS06085	COG0572	uridine kinase
AV939_RS06090	COG3769	mannosylglycerate metabolic process
AV939_RS06095	COG1215	transferase activity, transferring glycosyl groups
AV939_RS06105	COG0303	'Molybdopterin
AV939_RS06110	COG0534	Mate efflux family protein
AV939_RS06130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AV939_RS06140	COG0405	Gamma-glutamyltransferase
AV939_RS06145	COG1024	Enoyl-CoA hydratase
AV939_RS06180	COG1448	Aminotransferase
AV939_RS06185	COG1671	Belongs to the UPF0178 family
AV939_RS06190	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_RS06200	COG1960	acyl-CoA dehydrogenase activity
AV939_RS06205	COG2207	Transcriptional regulator
AV939_RS06205	COG1917	Cupin 2, conserved barrel domain protein
AV939_RS06255	COG0596	Alpha beta hydrolase
AV939_RS06265	COG0716	FMN binding
AV939_RS06285	COG3265	gluconokinase activity
AV939_RS06290	COG1609	Transcriptional regulator
AV939_RS06300	COG1984	allophanate hydrolase subunit 2
AV939_RS06310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AV939_RS06315	COG2996	Protein conserved in bacteria
AV939_RS06320	COG1765	OsmC-like protein
AV939_RS06325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AV939_RS06350	COG0436	Aminotransferase
AV939_RS06355	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AV939_RS06360	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AV939_RS06370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AV939_RS06380	COG1238	metal cluster binding
AV939_RS06425	COG4628	conserved protein (DUF2132)
AV939_RS06435	COG0454	-acetyltransferase
AV939_RS06440	COG1119	ATPase activity
AV939_RS06450	COG1185	polyribonucleotide nucleotidyltransferase activity
AV939_RS06465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AV939_RS06470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AV939_RS06475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AV939_RS06515	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AV939_RS06520	COG0149	triose-phosphate isomerase activity
AV939_RS06525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AV939_RS06530	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AV939_RS06540	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AV939_RS06545	COG1534	Rna-binding protein
AV939_RS06555	COG1067	ATP-dependent peptidase activity
AV939_RS06560	COG0495	leucyl-tRNA aminoacylation
AV939_RS06570	COG1466	dna polymerase III delta subunit
AV939_RS06575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AV939_RS06580	COG0799	negative regulation of ribosome biogenesis
AV939_RS06585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AV939_RS06590	COG0768	penicillin binding
AV939_RS06595	COG0772	Belongs to the SEDS family
AV939_RS06600	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AV939_RS06605	COG1686	Belongs to the peptidase S11 family
AV939_RS06610	COG2921	Belongs to the UPF0250 family
AV939_RS06615	COG0321	lipoyl(octanoyl) transferase activity
AV939_RS06620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AV939_RS06630	COG0252	asparaginase activity
AV939_RS06640	COG0778	Nitroreductase
AV939_RS06655	COG0616	signal peptide processing
AV939_RS06675	COG0492	ferredoxin-NADP+ reductase activity
AV939_RS06680	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AV939_RS06685	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AV939_RS06690	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AV939_RS06695	COG0542	response to heat
AV939_RS06700	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AV939_RS06705	COG1278	Cold shock
AV939_RS06715	COG1187	pseudouridine synthase activity
AV939_RS06720	COG0482	sulfurtransferase activity
AV939_RS06725	COG2915	High frequency lysogenization protein hflD homolog
AV939_RS06730	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AV939_RS06740	COG2850	peptidyl-arginine hydroxylation
AV939_RS06755	COG0247	lactate metabolic process
AV939_RS06755	COG0277	FAD linked oxidase domain protein
AV939_RS06760	COG3123	guanosine phosphorylase activity
AV939_RS06765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AV939_RS06810	COG1695	Transcriptional regulator
AV939_RS06825	COG1077	Cell shape determining protein MreB Mrl
AV939_RS06850	COG3265	gluconokinase activity
AV939_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_RS06875	COG1609	Transcriptional regulator
AV939_RS06880	COG0679	Auxin Efflux Carrier
AV939_RS06900	COG0574	Belongs to the PEP-utilizing enzyme family
AV939_RS06900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AV939_RS06920	COG1942	4-Oxalocrotonate Tautomerase
AV939_RS06940	COG1714	RDD family
AV939_RS06965	COG0702	epimerase
AV939_RS06975	COG0084	hydrolase, TatD family'
AV939_RS06980	COG0470	DNA polymerase III
AV939_RS06990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AV939_RS06995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AV939_RS07000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AV939_RS07005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AV939_RS07020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AV939_RS07025	COG0416	fatty acid biosynthetic process
AV939_RS07035	COG1399	metal-binding, possibly nucleic acid-binding protein
AV939_RS07040	COG0424	maF-like protein
AV939_RS07045	COG0546	phosphoglycolate phosphatase activity
AV939_RS07055	COG1530	ribonuclease E activity
AV939_RS07075	COG2153	protein acetylation
AV939_RS07095	COG0625	glutathione transferase activity
AV939_RS07110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AV939_RS07120	COG0583	DNA-binding transcription factor activity
AV939_RS07130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AV939_RS07135	COG3724	N-succinylarginine dihydrolase activity
AV939_RS07145	COG1301	dicarboxylic acid transport
AV939_RS07150	COG4591	ABC-type transport system involved in lipoprotein release permease component
AV939_RS07160	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AV939_RS07195	COG0328	RNA-DNA hybrid ribonuclease activity
AV939_RS07200	COG3321	synthase
AV939_RS07200	COG0604	alcohol dehydrogenase
AV939_RS07220	COG1643	Atp-dependent helicase
AV939_RS07260	COG2205	protein histidine kinase activity
AV939_RS07260	COG3850	Histidine kinase
AV939_RS07260	COG4999	Histidine kinase
AV939_RS07260	COG3437	response regulator, receiver
AV939_RS07265	COG2925	Exonuclease
AV939_RS07280	COG0183	Belongs to the thiolase family
AV939_RS07285	COG0789	Transcriptional regulator
AV939_RS07290	COG1960	acyl-CoA dehydrogenase activity
AV939_RS07295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AV939_RS07300	COG1024	Enoyl-CoA hydratase
AV939_RS07305	COG4770	biotin carboxylase activity
AV939_RS07335	COG1957	nucleoside hydrolase
AV939_RS07350	COG2814	Major facilitator Superfamily
AV939_RS07385	COG0708	Exodeoxyribonuclease III
AV939_RS07400	COG4591	ABC-type transport system involved in lipoprotein release permease component
AV939_RS07410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AV939_RS07420	COG2096	Adenosyltransferase
AV939_RS07430	COG1472	Belongs to the glycosyl hydrolase 3 family
AV939_RS07440	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AV939_RS07455	COG0072	phenylalanine-tRNA ligase activity
AV939_RS07455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV939_RS07485	COG2244	polysaccharide biosynthetic process
AV939_RS07495	COG0463	Glycosyl transferase, family 2
AV939_RS07500	COG0463	Glycosyl transferase, family 2
AV939_RS07500	COG1216	Glycosyl transferase, family 2
AV939_RS07515	COG1045	serine acetyltransferase
AV939_RS07525	COG0438	transferase activity, transferring glycosyl groups
AV939_RS07560	COG4464	protein tyrosine phosphatase activity
AV939_RS07565	COG0489	protein tyrosine kinase activity
AV939_RS07570	COG1596	polysaccharide export
AV939_RS07580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AV939_RS07600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AV939_RS07615	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_RS07645	COG0154	amidase activity
AV939_RS07655	COG0730	response to heat
AV939_RS07660	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AV939_RS07675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AV939_RS07680	COG2233	PERMEase
AV939_RS07695	COG0784	Response regulator, receiver
AV939_RS07695	COG5002	protein histidine kinase activity
AV939_RS07705	COG3300	MHYT domain
AV939_RS07705	COG5001	Diguanylate cyclase
AV939_RS07715	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AV939_RS07720	COG2252	PERMEase
AV939_RS07735	COG1309	transcriptional regulator
AV939_RS07745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AV939_RS07760	COG2351	hydroxyisourate hydrolase activity
AV939_RS07765	COG0402	S-adenosylhomocysteine deaminase activity
AV939_RS07775	COG5001	Diguanylate cyclase
AV939_RS07775	COG3447	MASE1 domain protein
AV939_RS07775	COG5002	protein histidine kinase activity
AV939_RS07795	COG3706	GGDEF domain
AV939_RS07810	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AV939_RS07835	COG2211	Major facilitator Superfamily
AV939_RS07835	COG2190	(PTS) system
AV939_RS07840	COG1393	Belongs to the ArsC family
AV939_RS07870	COG2988	succinylglutamate desuccinylase activity
AV939_RS07880	COG0058	SHG alpha-glucan phosphorylase activity
AV939_RS07885	COG0033	Phosphoglucomutase
AV939_RS07890	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AV939_RS07895	COG0714	Associated with various cellular activities
AV939_RS07910	COG2116	formate transmembrane transporter activity
AV939_RS07915	COG2815	serine threonine protein kinase
AV939_RS07915	COG0515	serine threonine protein kinase
AV939_RS07920	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
AV939_RS07925	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AV939_RS07945	COG0583	DNA-binding transcription factor activity
AV939_RS07955	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AV939_RS07965	COG0784	Response regulator, receiver
AV939_RS07965	COG3437	response regulator, receiver
AV939_RS07970	COG2890	protein-(glutamine-N5) methyltransferase activity
AV939_RS07980	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AV939_RS07985	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AV939_RS07990	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AV939_RS08000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AV939_RS08005	COG5001	Diguanylate cyclase
AV939_RS08015	COG1064	alcohol dehydrogenase
AV939_RS08030	COG0012	GTP binding
AV939_RS08035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AV939_RS08060	COG1115	amino acid carrier protein
AV939_RS08065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AV939_RS08080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AV939_RS08090	COG1702	phosphate starvation-inducible protein PhoH
AV939_RS08100	COG4535	Mg2 and Co2 transporter CorC
AV939_RS08105	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AV939_RS08110	COG0280	phosphate acetyltransferase
AV939_RS08110	COG0857	belongs to the CobB CobQ family
AV939_RS08120	COG0071	Belongs to the small heat shock protein (HSP20) family
AV939_RS08150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AV939_RS08155	COG0505	Belongs to the CarA family
AV939_RS08160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AV939_RS08175	COG3706	GGDEF domain
AV939_RS08175	COG2203	Gaf domain
AV939_RS08175	COG5001	Diguanylate cyclase
AV939_RS08175	COG4251	negative regulation of phosphorylation
AV939_RS08180	COG3909	cytochrome
AV939_RS08185	COG0484	heat shock protein binding
AV939_RS08195	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AV939_RS08200	COG2205	protein histidine kinase activity
AV939_RS08200	COG0784	Response regulator, receiver
AV939_RS08210	COG4771	TonB-dependent receptor
AV939_RS08215	COG2610	gluconate transmembrane transporter activity
AV939_RS08220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AV939_RS08230	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_RS08235	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AV939_RS08240	COG0497	DNA recombination
AV939_RS08245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AV939_RS08250	COG0500	methyltransferase
AV939_RS08255	COG2733	membrane
AV939_RS08270	COG0110	maltose O-acetyltransferase activity
AV939_RS08275	COG0656	L-ascorbic acid biosynthetic process
AV939_RS08290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AV939_RS08295	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AV939_RS08300	COG0009	L-threonylcarbamoyladenylate synthase
AV939_RS08305	COG0613	PHP domain protein
AV939_RS08310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AV939_RS08320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AV939_RS08325	COG0135	phosphoribosylanthranilate isomerase activity
AV939_RS08325	COG0134	indole-3-glycerol-phosphate synthase activity
AV939_RS08335	COG0159	tryptophan synthase activity
AV939_RS08340	COG2350	Protein conserved in bacteria
AV939_RS08360	COG2205	protein histidine kinase activity
AV939_RS08365	COG0628	permease
AV939_RS08370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AV939_RS08375	COG1090	epimerase
AV939_RS08380	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AV939_RS08385	COG4181	ATPase activity
AV939_RS08405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AV939_RS08435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AV939_RS08455	COG0745	RESPONSE REGULATOR receiver
AV939_RS08465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AV939_RS08470	COG5265	(ABC) transporter
AV939_RS08485	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AV939_RS08495	COG4139	cobalamin transport
AV939_RS08500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AV939_RS08515	COG1073	alpha beta
AV939_RS08515	COG2226	methyltransferase
AV939_RS08520	COG0156	8-amino-7-oxononanoate synthase activity
AV939_RS08545	COG0456	acetyltransferase
AV939_RS08550	COG0189	ligase activity
AV939_RS08565	COG0017	Asparaginyl-tRNA synthetase
AV939_RS08575	COG2995	paraquat-inducible protein a
AV939_RS08580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AV939_RS08580	COG3008	intermembrane lipid transfer
AV939_RS08610	COG0583	DNA-binding transcription factor activity
AV939_RS08615	COG1309	transcriptional regulator
AV939_RS08625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AV939_RS08630	COG0517	IMP dehydrogenase activity
AV939_RS08645	COG0583	DNA-binding transcription factor activity
AV939_RS08650	COG3038	cytochrome b561
AV939_RS08660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AV939_RS08690	COG2271	Major facilitator Superfamily
AV939_RS08695	COG0784	Response regulator, receiver
AV939_RS08695	COG2205	protein histidine kinase activity
AV939_RS08770	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AV939_RS08790	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AV939_RS08795	COG2885	chlorophyll binding
AV939_RS08800	COG0823	Involved in the tonB-independent uptake of proteins
AV939_RS08815	COG0811	peptide transport
AV939_RS08820	COG0824	Thioesterase
AV939_RS08825	COG2255	four-way junction helicase activity
AV939_RS08830	COG0632	four-way junction helicase activity
AV939_RS08835	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AV939_RS08840	COG0494	nUDIX hydrolase
AV939_RS08845	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AV939_RS08860	COG2204	response regulator
AV939_RS08870	COG2205	protein histidine kinase activity
AV939_RS08900	COG0023	Translation Initiation Factor
AV939_RS08905	COG0745	RESPONSE REGULATOR receiver
AV939_RS08910	COG0077	Prephenate dehydratase
AV939_RS08910	COG1605	Chorismate mutase
AV939_RS08915	COG0840	transmembrane signaling receptor activity
AV939_RS08920	COG1605	Chorismate mutase
AV939_RS08920	COG0287	Prephenate dehydrogenase
AV939_RS08925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AV939_RS08930	COG2860	membrane
AV939_RS08945	COG0335	large ribosomal subunit rRNA binding
AV939_RS08950	COG0336	Belongs to the RNA methyltransferase TrmD family
AV939_RS08955	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AV939_RS08960	COG0228	four-way junction DNA binding
AV939_RS08975	COG2873	o-acetylhomoserine
AV939_RS08980	COG1132	(ABC) transporter
AV939_RS08985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AV939_RS08995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AV939_RS09025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AV939_RS09030	COG4137	Cytochrome C assembly protein
AV939_RS09035	COG4536	flavin adenine dinucleotide binding
AV939_RS09045	COG2062	phosphohistidine phosphatase, SixA
AV939_RS09050	COG1025	Belongs to the peptidase M16 family
AV939_RS09065	COG1024	Enoyl-CoA hydratase
AV939_RS09065	COG1250	3-hydroxyacyl-CoA dehydrogenase
AV939_RS09075	COG0714	Associated with various cellular activities
AV939_RS09095	COG2304	oxidoreductase activity
AV939_RS09120	COG3706	GGDEF domain
AV939_RS09125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AV939_RS09130	COG0175	sulfate reduction
AV939_RS09135	COG0529	Catalyzes the synthesis of activated sulfate
AV939_RS09150	COG0471	metal ion transport
AV939_RS09150	COG3273	potassium ion transport
AV939_RS09175	COG0367	asparagine synthase
AV939_RS09185	COG0602	queuosine metabolic process
AV939_RS09210	COG0556	nucleotide-excision repair
AV939_RS09215	COG0534	Mate efflux family protein
AV939_RS09230	COG4657	Part of a membrane complex involved in electron transport
AV939_RS09235	COG2878	Part of a membrane complex involved in electron transport
AV939_RS09240	COG4656	Part of a membrane complex involved in electron transport
AV939_RS09245	COG4658	electron transport chain
AV939_RS09250	COG4659	FMN binding
AV939_RS09255	COG4660	Part of a membrane complex involved in electron transport
AV939_RS09260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AV939_RS09280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AV939_RS09285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AV939_RS09290	COG0823	Involved in the tonB-independent uptake of proteins
AV939_RS09290	COG1506	peptidase
AV939_RS09290	COG4946	Tricorn protease homolog
AV939_RS09315	COG1278	Cold shock
AV939_RS09320	COG0346	lactoylglutathione lyase activity
AV939_RS09325	COG0584	glycerophosphoryl diester phosphodiesterase
AV939_RS09330	COG2885	chlorophyll binding
AV939_RS09335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AV939_RS09340	COG0450	alkyl hydroperoxide reductase
AV939_RS09365	COG4771	TonB-dependent receptor
AV939_RS09370	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AV939_RS09375	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AV939_RS09380	COG2766	serine protein kinase
AV939_RS09385	COG2718	Belongs to the UPF0229 family
AV939_RS09390	COG2719	SpoVR family
AV939_RS09410	COG2890	protein-(glutamine-N5) methyltransferase activity
AV939_RS09415	COG2840	Smr protein MutS2
AV939_RS09440	COG1136	(ABC) transporter
AV939_RS09460	COG2918	glutathione biosynthetic process
AV939_RS09465	COG0612	Peptidase, M16
AV939_RS09475	COG0564	pseudouridine synthase activity
AV939_RS09480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AV939_RS09485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AV939_RS09510	COG2175	clavaminate synthase activity
AV939_RS09540	COG0583	DNA-binding transcription factor activity
AV939_RS09555	COG0456	acetyltransferase
AV939_RS09610	COG0848	biopolymer transport protein
AV939_RS09615	COG0811	peptide transport
AV939_RS09620	COG0811	peptide transport
AV939_RS09660	COG0457	Tetratricopeptide repeat
AV939_RS09690	COG1522	sequence-specific DNA binding
AV939_RS09695	COG0625	glutathione transferase activity
AV939_RS09725	COG1842	Phage shock protein A
AV939_RS09730	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AV939_RS09735	COG0747	negative chemotaxis
AV939_RS09740	COG4168	peptide transport system, permease
AV939_RS09745	COG4171	peptide transport system, permease
AV939_RS09750	COG4172	Belongs to the ABC transporter superfamily
AV939_RS09755	COG4172	Belongs to the ABC transporter superfamily
AV939_RS09760	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AV939_RS09775	COG1607	acyl-coa hydrolase
AV939_RS09800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AV939_RS09815	COG3590	peptidase
AV939_RS09820	COG1309	transcriptional regulator
AV939_RS09830	COG0659	secondary active sulfate transmembrane transporter activity
AV939_RS09835	COG0288	reversible hydration of carbon dioxide
AV939_RS09840	COG0583	DNA-binding transcription factor activity
AV939_RS09845	COG0583	DNA-binding transcription factor activity
AV939_RS09855	COG0646	methionine synthase
AV939_RS09855	COG1410	methionine synthase
AV939_RS09860	COG0646	methionine synthase
AV939_RS09860	COG1410	methionine synthase
AV939_RS09875	COG0835	chemotaxis
AV939_RS09885	COG1192	Involved in chromosome partitioning
AV939_RS09890	COG2201	protein-glutamate methylesterase activity
AV939_RS09895	COG2198	Histidine kinase
AV939_RS09895	COG0643	Histidine kinase
AV939_RS09895	COG0784	Response regulator, receiver
AV939_RS09900	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AV939_RS09925	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AV939_RS09940	COG1987	bacterial-type flagellum assembly
AV939_RS09990	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AV939_RS09995	COG1766	The M ring may be actively involved in energy transduction
AV939_RS10025	COG1086	Polysaccharide biosynthesis protein
AV939_RS10030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AV939_RS10035	COG1083	cytidylyl-transferase
AV939_RS10045	COG2089	acid synthase
AV939_RS10060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AV939_RS10100	COG2089	acid synthase
AV939_RS10105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AV939_RS10110	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AV939_RS10150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AV939_RS10155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AV939_RS10175	COG1256	bacterial-type flagellum assembly
AV939_RS10180	COG1705	Flagellar rod assembly protein muramidase FlgJ
AV939_RS10180	COG3951	Flagellar rod assembly protein muramidase FlgJ
AV939_RS10200	COG4787	bacterial-type flagellum-dependent cell motility
AV939_RS10205	COG1749	Flagellar hook protein flgE
AV939_RS10220	COG1815	bacterial-type flagellum-dependent cell motility
AV939_RS10225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AV939_RS10230	COG0835	chemotaxis
AV939_RS10230	COG0784	Response regulator, receiver
AV939_RS10270	COG2197	response regulator
AV939_RS10275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AV939_RS10285	COG2885	chlorophyll binding
AV939_RS10390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AV939_RS10390	COG2205	protein histidine kinase activity
AV939_RS10400	COG0205	6-phosphofructokinase activity
AV939_RS10405	COG3279	Response regulator of the LytR AlgR family
AV939_RS10410	COG3275	phosphorelay sensor kinase activity
AV939_RS10440	COG3081	Nucleoid-associated protein
AV939_RS10445	COG3082	Protein of unknown function (DUF1414)
AV939_RS10450	COG3083	sulfuric ester hydrolase activity
AV939_RS10460	COG2226	methyltransferase
AV939_RS10465	COG1024	Enoyl-CoA hydratase
AV939_RS10470	COG1960	acyl-CoA dehydrogenase activity
AV939_RS10480	COG2084	Dehydrogenase
AV939_RS10485	COG0386	Belongs to the glutathione peroxidase family
AV939_RS10490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AV939_RS10495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AV939_RS10500	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AV939_RS10525	COG0616	signal peptide processing
AV939_RS10535	COG2267	carboxylic ester hydrolase activity
AV939_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_RS10550	COG1609	Transcriptional regulator
AV939_RS10565	COG0366	Alpha amylase catalytic
AV939_RS10585	COG4667	esterase of the alpha-beta hydrolase superfamily
AV939_RS10620	COG0508	dehydrogenase complex catalyzes the overall conversion of
AV939_RS10625	COG0567	Dehydrogenase, E1 component
AV939_RS10635	COG1053	succinate dehydrogenase
AV939_RS10640	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AV939_RS10665	COG0435	Glutathione S-transferase
AV939_RS10670	COG0579	oxidoreductase
AV939_RS10675	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AV939_RS10715	COG1663	tetraacyldisaccharide 4'-kinase activity
AV939_RS10720	COG1132	(ABC) transporter
AV939_RS10735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AV939_RS10745	COG1196	nuclear chromosome segregation
AV939_RS10765	COG0295	cytidine deaminase activity
AV939_RS10790	COG0477	Major facilitator Superfamily
AV939_RS10810	COG2318	DinB family
AV939_RS10815	COG0457	Tetratricopeptide repeat
AV939_RS10825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AV939_RS10835	COG2914	Belongs to the UPF0125 (RnfH) family
AV939_RS10840	COG2867	negative regulation of translational initiation
AV939_RS10880	COG0582	viral genome integration into host DNA
AV939_RS10905	COG4771	TonB-dependent receptor
AV939_RS10910	COG2814	Major facilitator Superfamily
AV939_RS10940	COG1012	belongs to the aldehyde dehydrogenase family
AV939_RS10950	COG1595	DNA-templated transcription, initiation
AV939_RS10980	COG0583	DNA-binding transcription factor activity
AV939_RS11000	COG5001	Diguanylate cyclase
AV939_RS11000	COG3300	MHYT domain
AV939_RS11015	COG5001	Diguanylate cyclase
AV939_RS11015	COG4251	negative regulation of phosphorylation
AV939_RS11015	COG3706	GGDEF domain
AV939_RS11015	COG2203	Gaf domain
AV939_RS11030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AV939_RS11035	COG4136	ATPase activity
AV939_RS11040	COG4135	transport system, permease component
AV939_RS11045	COG4134	Bacterial extracellular solute-binding protein
AV939_RS11060	COG4771	TonB-dependent receptor
AV939_RS11075	COG1032	radical SAM domain protein
AV939_RS11100	COG4774	siderophore transport
AV939_RS11135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AV939_RS11135	COG3153	acetyltransferase
AV939_RS11145	COG0596	Alpha beta hydrolase
AV939_RS11150	COG3706	GGDEF domain
AV939_RS11160	COG4269	membrane
AV939_RS11170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AV939_RS11185	COG0195	Participates in both transcription termination and antitermination
AV939_RS11195	COG3437	response regulator, receiver
AV939_RS11200	COG0784	Response regulator, receiver
AV939_RS11200	COG2198	Histidine kinase
AV939_RS11200	COG2205	protein histidine kinase activity
AV939_RS11220	COG4771	TonB-dependent receptor
AV939_RS11225	COG0668	transmembrane transport
AV939_RS11245	COG0668	transmembrane transport
AV939_RS11265	COG0246	Mannitol dehydrogenase
AV939_RS11275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AV939_RS11280	COG2390	Transcriptional regulator
AV939_RS11390	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_RS11425	COG0436	Aminotransferase
AV939_RS11430	COG3268	Saccharopine dehydrogenase
AV939_RS11445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AV939_RS11460	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AV939_RS11465	COG1074	ATP-dependent DNA helicase activity
AV939_RS11470	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AV939_RS11480	COG1022	Amp-dependent synthetase and ligase
AV939_RS11485	COG3300	MHYT domain
AV939_RS11485	COG5001	Diguanylate cyclase
AV939_RS11495	COG3132	Protein of unknown function, DUF480
AV939_RS11510	COG0583	DNA-binding transcription factor activity
AV939_RS11530	COG0640	Transcriptional regulator
AV939_RS11540	COG0583	DNA-binding transcription factor activity
AV939_RS11550	COG2204	response regulator
AV939_RS11560	COG4251	negative regulation of phosphorylation
AV939_RS11565	COG0784	Response regulator, receiver
AV939_RS11570	COG0784	Response regulator, receiver
AV939_RS11570	COG2205	protein histidine kinase activity
AV939_RS11595	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AV939_RS11620	COG3139	Protein of unknown function (DUF1315)
AV939_RS11630	COG1115	amino acid carrier protein
AV939_RS11635	COG2866	Carboxypeptidase
AV939_RS11655	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AV939_RS11665	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AV939_RS11670	COG1640	4-alpha-glucanotransferase
AV939_RS11680	COG0676	glucose-6-phosphate 1-epimerase activity
AV939_RS11685	COG0800	Aldolase
AV939_RS11695	COG0129	dihydroxy-acid dehydratase activity
AV939_RS11705	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AV939_RS11710	COG1737	Transcriptional regulator
AV939_RS11715	COG0469	pyruvate kinase activity
AV939_RS11720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AV939_RS11765	COG2205	protein histidine kinase activity
AV939_RS11770	COG0745	RESPONSE REGULATOR receiver
AV939_RS11795	COG3665	Urea carboxylase-associated protein
AV939_RS11805	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_RS11810	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AV939_RS11835	COG2721	sulfolactate sulfo-lyase activity
AV939_RS11840	COG1904	glucuronate isomerase
AV939_RS11845	COG0246	Mannitol dehydrogenase
AV939_RS11850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AV939_RS11855	COG2755	lipolytic protein G-D-S-L family
AV939_RS11865	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AV939_RS11875	COG4677	pectinesterase activity
AV939_RS11880	COG4999	Histidine kinase
AV939_RS11880	COG3850	Histidine kinase
AV939_RS11880	COG3437	response regulator, receiver
AV939_RS11880	COG2205	protein histidine kinase activity
AV939_RS11895	COG2356	endonuclease I
AV939_RS11905	COG1024	Enoyl-CoA hydratase
AV939_RS11925	COG1609	Transcriptional regulator
AV939_RS11930	COG4948	Mandelate Racemase Muconate Lactonizing
AV939_RS11935	COG0673	inositol 2-dehydrogenase activity
AV939_RS11965	COG0746	molybdenum cofactor guanylyltransferase activity
AV939_RS11975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AV939_RS11980	COG1764	response to oxidative stress
AV939_RS12005	COG0745	RESPONSE REGULATOR receiver
AV939_RS12010	COG5002	protein histidine kinase activity
AV939_RS12010	COG3850	Histidine kinase
AV939_RS12045	COG0738	Major facilitator superfamily
AV939_RS12070	COG0840	transmembrane signaling receptor activity
AV939_RS12080	COG0753	catalase activity
AV939_RS12090	COG0330	HflC and HflK could
AV939_RS12110	COG0778	Nitroreductase
AV939_RS12130	COG0471	metal ion transport
AV939_RS12140	COG0489	protein tyrosine kinase activity
AV939_RS12145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV939_RS12145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV939_RS12150	COG2226	methyltransferase
AV939_RS12155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AV939_RS12160	COG1388	LysM domain
AV939_RS12160	COG0741	lytic transglycosylase activity
AV939_RS12180	COG2942	2-epimerase
AV939_RS12185	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AV939_RS12195	COG1609	Transcriptional regulator
AV939_RS12200	COG2942	2-epimerase
AV939_RS12205	COG3119	arylsulfatase activity
AV939_RS12220	COG4124	Belongs to the glycosyl hydrolase 26 family
AV939_RS12255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AV939_RS12265	COG1785	Belongs to the alkaline phosphatase family
AV939_RS12270	COG1785	Belongs to the alkaline phosphatase family
AV939_RS12285	COG2268	Band 7 protein
AV939_RS12305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AV939_RS12310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AV939_RS12315	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AV939_RS12320	COG2080	2 iron, 2 sulfur cluster binding
AV939_RS12330	COG0604	alcohol dehydrogenase
AV939_RS12340	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AV939_RS12365	COG0084	hydrolase, TatD family'
AV939_RS12385	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AV939_RS12390	COG1286	toxin biosynthetic process
AV939_RS12395	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AV939_RS12400	COG0285	dihydrofolate synthase activity
AV939_RS12410	COG0101	tRNA pseudouridine synthase activity
AV939_RS12425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AV939_RS12445	COG3706	GGDEF domain
AV939_RS12450	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AV939_RS12450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AV939_RS12480	COG3101	peptidyl-lysine hydroxylation
AV939_RS12525	COG0446	pyridine nucleotide-disulphide oxidoreductase
AV939_RS12525	COG1902	pentaerythritol trinitrate reductase activity
AV939_RS12550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AV939_RS12555	COG1309	transcriptional regulator
AV939_RS12560	COG4399	Belongs to the UPF0754 family
AV939_RS12595	COG2186	Transcriptional regulator
AV939_RS12605	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AV939_RS12610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AV939_RS12615	COG2983	Belongs to the UPF0260 family
AV939_RS12620	COG0179	Fumarylacetoacetate (FAA) hydrolase
AV939_RS12635	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AV939_RS12640	COG0318	PFAM AMP-dependent synthetase and ligase
AV939_RS12645	COG2267	carboxylic ester hydrolase activity
AV939_RS12660	COG1214	PFAM Peptidase M22, glycoprotease
AV939_RS12665	COG1199	ATP-dependent helicase activity
AV939_RS12725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AV939_RS12730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AV939_RS12735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AV939_RS12740	COG0131	Imidazoleglycerol-phosphate dehydratase
AV939_RS12740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AV939_RS12745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AV939_RS12760	COG0140	phosphoribosyl-ATP diphosphatase activity
AV939_RS12760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AV939_RS12770	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_RS12780	COG1022	Amp-dependent synthetase and ligase
AV939_RS12800	COG0463	Glycosyl transferase, family 2
AV939_RS12820	COG0642	Histidine kinase
AV939_RS12830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AV939_RS12835	COG0681	Belongs to the peptidase S26 family
AV939_RS12855	COG0326	Molecular chaperone. Has ATPase activity
AV939_RS12860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AV939_RS12885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AV939_RS12890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AV939_RS12900	COG3220	belongs to the UPF0276 family
AV939_RS12910	COG4249	Peptidase C14 caspase catalytic subunit p20
AV939_RS12910	COG2319	Wd-40 repeat
AV939_RS12925	COG3706	GGDEF domain
AV939_RS12925	COG2203	Gaf domain
AV939_RS12925	COG5001	Diguanylate cyclase
AV939_RS12925	COG4251	negative regulation of phosphorylation
AV939_RS12960	COG1183	phosphatidylcholine synthase activity
AV939_RS12980	COG0542	response to heat
AV939_RS12985	COG1496	oxidoreductase activity
AV939_RS12990	COG0564	pseudouridine synthase activity
AV939_RS13005	COG1595	DNA-templated transcription, initiation
AV939_RS13020	COG4221	oxidoreductase activity
AV939_RS13025	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AV939_RS13035	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AV939_RS13045	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AV939_RS13050	COG1722	exodeoxyribonuclease VII activity
AV939_RS13055	COG0142	geranyltranstransferase activity
AV939_RS13065	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AV939_RS13070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AV939_RS13080	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AV939_RS13095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AV939_RS13095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AV939_RS13110	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AV939_RS13115	COG0488	(ABC) transporter
AV939_RS13125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AV939_RS13135	COG0560	Phosphoserine phosphatase
AV939_RS13145	COG0084	hydrolase, TatD family'
AV939_RS13190	COG1595	DNA-templated transcription, initiation
AV939_RS13195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AV939_RS13210	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AV939_RS13230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AV939_RS13290	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AV939_RS13295	COG1047	Peptidyl-prolyl cis-trans
AV939_RS13305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AV939_RS13310	COG0196	riboflavin kinase activity
AV939_RS13315	COG0728	peptidoglycan biosynthetic process
AV939_RS13320	COG0268	Binds directly to 16S ribosomal RNA
AV939_RS13340	COG0385	Bile acid
AV939_RS13365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AV939_RS13370	COG0776	regulation of translation
AV939_RS13375	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AV939_RS13380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AV939_RS13385	COG0740	serine-type endopeptidase activity
AV939_RS13390	COG0544	peptidyl-prolyl cis-trans isomerase activity
AV939_RS13430	COG1720	tRNA m6t6A37 methyltransferase activity
AV939_RS13450	COG0123	including yeast histone deacetylase and acetoin utilization protein
AV939_RS13470	COG0517	IMP dehydrogenase activity
AV939_RS13470	COG0516	GMP reductase activity
AV939_RS13475	COG1570	exodeoxyribonuclease VII activity
AV939_RS13490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AV939_RS13495	COG2976	Protein conserved in bacteria
AV939_RS13520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AV939_RS13530	COG2166	iron-sulfur cluster assembly
AV939_RS13545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AV939_RS13550	COG0719	Fe-S assembly protein
AV939_RS13555	COG0396	ATPase activity
AV939_RS13560	COG0719	Fe-S assembly protein
AV939_RS13565	COG1104	cysteine desulfurase activity
AV939_RS13580	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AV939_RS13585	COG0483	inositol monophosphate 1-phosphatase activity
AV939_RS13615	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AV939_RS13620	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AV939_RS13625	COG1862	Preprotein translocase
AV939_RS13630	COG0343	queuine tRNA-ribosyltransferase activity
AV939_RS13645	COG3789	protein conserved in bacteria
AV939_RS13650	COG1842	Phage shock protein A
AV939_RS13675	COG0754	glutathionylspermidine amidase activity
AV939_RS13690	COG2066	Belongs to the glutaminase family
AV939_RS13695	COG1785	Belongs to the alkaline phosphatase family
AV939_RS13700	COG0745	RESPONSE REGULATOR receiver
AV939_RS13750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AV939_RS13755	COG1045	serine acetyltransferase
AV939_RS13780	COG0438	transferase activity, transferring glycosyl groups
AV939_RS13825	COG0463	Glycosyl transferase, family 2
AV939_RS13825	COG1216	Glycosyl transferase, family 2
AV939_RS13860	COG0489	protein tyrosine kinase activity
AV939_RS13870	COG3267	Type II secretory pathway component ExeA
AV939_RS13870	COG3409	Peptidoglycan-binding domain 1 protein
AV939_RS13875	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AV939_RS13875	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AV939_RS13880	COG2827	Endonuclease containing a URI domain
AV939_RS13900	COG1560	Kdo2-lipid A biosynthetic process
AV939_RS13930	COG1960	acyl-CoA dehydrogenase activity
AV939_RS13945	COG1435	thymidine kinase activity
AV939_RS13955	COG1609	Transcriptional regulator
AV939_RS13960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AV939_RS14000	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AV939_RS14005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AV939_RS14010	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AV939_RS14015	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AV939_RS14040	COG2815	serine threonine protein kinase
AV939_RS14040	COG0515	serine threonine protein kinase
AV939_RS14050	COG1982	Orn Lys Arg decarboxylase major
AV939_RS14075	COG4774	siderophore transport
AV939_RS14090	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_RS14105	COG1629	transport
AV939_RS14105	COG4774	siderophore transport
AV939_RS14110	COG4682	membrane
AV939_RS14125	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AV939_RS14130	COG0789	Transcriptional regulator
AV939_RS14145	COG0189	ligase activity
AV939_RS14200	COG1960	acyl-CoA dehydrogenase activity
AV939_RS14230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AV939_RS14240	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AV939_RS14290	COG1607	acyl-coa hydrolase
AV939_RS14295	COG0826	peptidase U32
AV939_RS14360	COG0583	DNA-binding transcription factor activity
AV939_RS14375	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_RS14380	COG1733	regulation of RNA biosynthetic process
AV939_RS14395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AV939_RS14430	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_RS14440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AV939_RS14445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AV939_RS14460	COG0109	protoheme IX farnesyltransferase activity
AV939_RS14475	COG0583	DNA-binding transcription factor activity
AV939_RS14490	COG4221	oxidoreductase activity
AV939_RS14495	COG0693	protein deglycase activity
AV939_RS14555	COG0789	Transcriptional regulator
AV939_RS14585	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AV939_RS14590	COG1335	isochorismatase
AV939_RS14595	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AV939_RS14615	COG4771	TonB-dependent receptor
AV939_RS14650	COG1566	PFAM secretion protein HlyD family protein
AV939_RS14655	COG1846	Transcriptional regulator
AV939_RS14665	COG1295	ribonuclease BN
AV939_RS14675	COG0514	ATP-dependent DNA helicase (RecQ)
AV939_RS14700	COG0583	DNA-binding transcription factor activity
AV939_RS14710	COG0484	heat shock protein binding
AV939_RS14715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AV939_RS14715	COG1017	nitric oxide dioxygenase activity
AV939_RS14730	COG3604	Transcriptional regulator
AV939_RS14755	COG2319	Wd-40 repeat
AV939_RS14755	COG4249	Peptidase C14 caspase catalytic subunit p20
AV939_RS14770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AV939_RS14790	COG1451	nucleotide metabolic process
AV939_RS14805	COG0653	protein targeting
AV939_RS14820	COG1757	Na H antiporter
AV939_RS14840	COG2133	pyrroloquinoline quinone binding
AV939_RS14850	COG0697	spore germination
AV939_RS14855	COG3813	Protein conserved in bacteria
AV939_RS14860	COG0513	Belongs to the DEAD box helicase family
AV939_RS14910	COG2814	Major facilitator Superfamily
AV939_RS14920	COG0656	L-ascorbic acid biosynthetic process
AV939_RS14975	COG2801	Transposase and inactivated derivatives
AV939_RS15000	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AV939_RS15000	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AV939_RS15015	COG0583	DNA-binding transcription factor activity
AV939_RS15035	COG1621	beta-fructofuranosidase activity
AV939_RS15040	COG2814	Major facilitator Superfamily
AV939_RS15050	COG1629	transport
AV939_RS15075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AV939_RS15080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AV939_RS15085	COG0006	proline dipeptidase activity
AV939_RS15100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AV939_RS15115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AV939_RS15120	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AV939_RS15125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AV939_RS15145	COG3313	Fe-S protein
AV939_RS15185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AV939_RS15190	COG0508	dehydrogenase complex catalyzes the overall conversion of
AV939_RS15195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AV939_RS15225	COG4969	Belongs to the N-Me-Phe pilin family
AV939_RS15230	COG1459	type II secretion system
AV939_RS15240	COG0237	dephospho-CoA kinase activity
AV939_RS15240	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AV939_RS15245	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AV939_RS15250	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AV939_RS15255	COG2988	succinylglutamate desuccinylase activity
AV939_RS15260	COG0494	nUDIX hydrolase
AV939_RS15270	COG0739	heme binding
AV939_RS15275	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AV939_RS15285	COG0849	cell division
AV939_RS15290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AV939_RS15295	COG1181	Belongs to the D-alanine--D-alanine ligase family
AV939_RS15300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AV939_RS15310	COG0772	Belongs to the SEDS family
AV939_RS15315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AV939_RS15325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AV939_RS15330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AV939_RS15335	COG0768	penicillin binding
AV939_RS15340	COG3116	cell division
AV939_RS15350	COG2001	Belongs to the MraZ family
AV939_RS15390	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AV939_RS15390	COG0678	peroxiredoxin activity
AV939_RS15405	COG2204	response regulator
AV939_RS15410	COG2198	Histidine kinase
AV939_RS15410	COG0784	Response regulator, receiver
AV939_RS15410	COG5002	protein histidine kinase activity
AV939_RS15430	COG0668	transmembrane transport
AV939_RS15435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AV939_RS15440	COG0189	ligase activity
AV939_RS15445	COG1678	Uncharacterized ACR, COG1678
AV939_RS15450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AV939_RS15470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AV939_RS15475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AV939_RS15480	COG0762	integral membrane protein
AV939_RS15495	COG0446	pyridine nucleotide-disulphide oxidoreductase
AV939_RS15495	COG1902	pentaerythritol trinitrate reductase activity
AV939_RS15510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV939_RS15515	COG0625	glutathione transferase activity
AV939_RS15545	COG0083	homoserine kinase activity
AV939_RS15555	COG0583	DNA-binding transcription factor activity
AV939_RS15565	COG2197	response regulator
AV939_RS15570	COG4585	Histidine kinase
AV939_RS15590	COG0640	Transcriptional regulator
AV939_RS15600	COG0431	NADPH-dependent FMN reductase
AV939_RS15605	COG0798	PFAM Bile acid sodium symporter
AV939_RS15610	COG2201	protein-glutamate methylesterase activity
AV939_RS15615	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AV939_RS15620	COG0745	RESPONSE REGULATOR receiver
AV939_RS15625	COG5002	protein histidine kinase activity
AV939_RS15650	COG1748	Saccharopine dehydrogenase
AV939_RS15665	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AV939_RS15670	COG3107	peptidoglycan biosynthetic process
AV939_RS15675	COG0792	nuclease activity
AV939_RS15685	COG2823	Periplasmic or secreted lipoprotein
AV939_RS15730	COG4585	Histidine kinase
AV939_RS15735	COG2197	response regulator
AV939_RS15740	COG4771	TonB-dependent receptor
AV939_RS15750	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AV939_RS15755	COG0372	Belongs to the citrate synthase family
AV939_RS15765	COG2828	Protein conserved in bacteria
AV939_RS15770	COG2203	Gaf domain
AV939_RS15770	COG2199	diguanylate cyclase activity
AV939_RS15795	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AV939_RS15815	COG0784	Response regulator, receiver
AV939_RS15815	COG2198	Histidine kinase
AV939_RS15815	COG5002	protein histidine kinase activity
AV939_RS15820	COG0067	glutamate synthase
AV939_RS15820	COG0069	glutamate synthase activity
AV939_RS15820	COG0070	glutamate synthase
AV939_RS15825	COG0493	'glutamate synthase
AV939_RS15835	COG1476	TRANSCRIPTIONal
AV939_RS15875	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AV939_RS15885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AV939_RS15890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AV939_RS15905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AV939_RS15910	COG0739	heme binding
AV939_RS15915	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AV939_RS15925	COG0738	Major facilitator superfamily
AV939_RS15930	COG3659	wide pore channel activity
AV939_RS15935	COG1902	pentaerythritol trinitrate reductase activity
AV939_RS15945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AV939_RS15950	COG0625	glutathione transferase activity
AV939_RS15970	COG2894	cell division
AV939_RS15975	COG0850	regulation of cytokinetic process
AV939_RS16000	COG1981	membrane
AV939_RS16015	COG1914	H( )-stimulated, divalent metal cation uptake system
AV939_RS16020	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AV939_RS16035	COG1217	gtp-binding protein TYPA
AV939_RS16040	COG0174	glutamine synthetase
AV939_RS16050	COG3852	Histidine kinase
AV939_RS16060	COG3437	response regulator, receiver
AV939_RS16080	COG3706	GGDEF domain
AV939_RS16095	COG0525	valine-tRNA ligase activity
AV939_RS16100	COG2927	DNA polymerase III (CHI subunit)
AV939_RS16105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AV939_RS16110	COG0795	lipopolysaccharide-transporting ATPase activity
AV939_RS16115	COG0795	lipopolysaccharide-transporting ATPase activity
AV939_RS16180	COG1082	Xylose isomerase domain protein TIM barrel
AV939_RS16265	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AV939_RS16335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AV939_RS16345	COG0395	ABC-type sugar transport system, permease component
AV939_RS16365	COG3706	GGDEF domain
AV939_RS16370	COG3706	GGDEF domain
AV939_RS16410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AV939_RS16415	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AV939_RS16420	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AV939_RS16430	COG0535	radical SAM domain protein
AV939_RS16460	COG2205	protein histidine kinase activity
AV939_RS16460	COG0784	Response regulator, receiver
AV939_RS16470	COG3901	Regulator of nitric oxide reductase transcription
AV939_RS16470	COG0348	domain, Protein
AV939_RS16480	COG2197	response regulator
AV939_RS16485	COG4585	Histidine kinase
AV939_RS16515	COG4771	TonB-dependent receptor
AV939_RS16520	COG1858	cytochrome C peroxidase
AV939_RS16550	COG1028	Short-chain dehydrogenase reductase Sdr
AV939_RS16560	COG1917	Cupin 2, conserved barrel domain protein
AV939_RS16565	COG2271	Major facilitator Superfamily
AV939_RS16585	COG1716	ATPase activity
AV939_RS16620	COG1357	PFAM Pentapeptide repeats (8 copies)
AV939_RS16620	COG0515	serine threonine protein kinase
AV939_RS16635	COG1716	ATPase activity
AV939_RS16635	COG1131	(ABC) transporter
AV939_RS16635	COG0842	Transport permease protein
AV939_RS16640	COG0513	Belongs to the DEAD box helicase family
AV939_RS16645	COG0800	Aldolase
AV939_RS16650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AV939_RS16655	COG2186	Transcriptional regulator
AV939_RS16665	COG3264	Mechanosensitive ion channel
AV939_RS16665	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AV939_RS16700	COG3568	Endonuclease Exonuclease Phosphatase
AV939_RS16715	COG0730	response to heat
AV939_RS16720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AV939_RS16735	COG4191	Histidine kinase
AV939_RS16745	COG0417	DNA replication proofreading
AV939_RS16795	COG1309	transcriptional regulator
AV939_RS16810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AV939_RS16820	COG1573	uracil-dna glycosylase
AV939_RS16825	COG5001	Diguanylate cyclase
AV939_RS16825	COG3300	MHYT domain
AV939_RS16845	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AV939_RS16850	COG4771	TonB-dependent receptor
AV939_RS16875	COG1842	Phage shock protein A
AV939_RS16885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AV939_RS16910	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AV939_RS16915	COG0204	Acyl-transferase
AV939_RS16920	COG0204	Acyl-transferase
AV939_RS16925	COG0668	transmembrane transport
AV939_RS16940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AV939_RS16945	COG0733	neurotransmitter:sodium symporter activity
AV939_RS16960	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AV939_RS16985	COG0848	biopolymer transport protein
AV939_RS16995	COG0457	Tetratricopeptide repeat
AV939_RS17025	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AV939_RS17030	COG0702	epimerase
AV939_RS17045	COG5001	Diguanylate cyclase
AV939_RS17045	COG5002	protein histidine kinase activity
AV939_RS17055	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AV939_RS17060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AV939_RS17070	COG0583	DNA-binding transcription factor activity
AV939_RS17075	COG0121	glutamine amidotransferase
AV939_RS17090	COG1522	sequence-specific DNA binding
AV939_RS17105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AV939_RS17115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AV939_RS17125	COG1477	protein flavinylation
AV939_RS17130	COG2871	sodium ion transport
AV939_RS17135	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AV939_RS17140	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AV939_RS17145	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AV939_RS17150	COG1805	sodium ion transport
AV939_RS17155	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AV939_RS17160	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AV939_RS17165	COG0545	Peptidyl-prolyl cis-trans isomerase
AV939_RS17170	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AV939_RS17180	COG0039	L-malate dehydrogenase activity
AV939_RS17185	COG1438	arginine binding
AV939_RS17215	COG0572	uridine kinase
AV939_RS17220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AV939_RS17230	COG0457	Tetratricopeptide repeat
AV939_RS17235	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AV939_RS17255	COG0517	IMP dehydrogenase activity
AV939_RS17255	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AV939_RS17260	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AV939_RS17280	COG0189	ligase activity
AV939_RS17290	COG4067	protein conserved in archaea
AV939_RS17290	COG0189	ligase activity
AV939_RS17305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AV939_RS17320	COG1283	sodium-dependent phosphate transmembrane transporter activity
AV939_RS17325	COG0667	Aldo Keto reductase
AV939_RS17340	COG0753	catalase activity
AV939_RS17375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AV939_RS17380	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AV939_RS17380	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AV939_RS17385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AV939_RS17440	COG0583	DNA-binding transcription factor activity
AV939_RS17455	COG0438	transferase activity, transferring glycosyl groups
AV939_RS17455	COG1216	Glycosyl transferase, family 2
AV939_RS17485	COG1216	Glycosyl transferase, family 2
AV939_RS17490	COG1216	Glycosyl transferase, family 2
AV939_RS17500	COG1215	transferase activity, transferring glycosyl groups
AV939_RS17515	COG0110	maltose O-acetyltransferase activity
AV939_RS17525	COG1216	Glycosyl transferase, family 2
AV939_RS17540	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AV939_RS17540	COG0662	Cupin 2, conserved barrel domain protein
AV939_RS17550	COG0202	RNA polymerase activity
AV939_RS17570	COG0201	protein transport
AV939_RS17590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AV939_RS17625	COG5002	protein histidine kinase activity
AV939_RS17625	COG0784	Response regulator, receiver
AV939_RS17640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AV939_RS17645	COG0557	exoribonuclease II activity
AV939_RS17660	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AV939_RS17675	COG0543	2 iron, 2 sulfur cluster binding
AV939_RS17680	COG2234	aminopeptidase activity
AV939_RS17700	COG1271	oxidase subunit
AV939_RS17705	COG1294	oxidase, subunit
AV939_RS17710	COG0840	transmembrane signaling receptor activity
AV939_RS17715	COG1522	sequence-specific DNA binding
AV939_RS17730	COG1278	Cold shock
AV939_RS17735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AV939_RS17755	COG0339	signal peptide processing
AV939_RS17760	COG2201	protein-glutamate methylesterase activity
AV939_RS17770	COG4191	Histidine kinase
AV939_RS17770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AV939_RS17780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AV939_RS17785	COG0243	molybdopterin cofactor binding
AV939_RS17790	COG4946	Tricorn protease homolog
AV939_RS17790	COG0793	Belongs to the peptidase S41A family
AV939_RS17830	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AV939_RS17835	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AV939_RS17840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AV939_RS17855	COG0281	malic enzyme
AV939_RS17860	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AV939_RS17865	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AV939_RS17895	COG0456	acetyltransferase
AV939_RS17905	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AV939_RS17910	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AV939_RS17915	COG2177	Part of the ABC transporter FtsEX involved in
AV939_RS17920	COG2884	Cell division ATP-binding protein ftsE
AV939_RS17925	COG0552	protein localization to endoplasmic reticulum
AV939_RS17930	COG0742	ribosomal rna small subunit methyltransferase
AV939_RS17940	COG2095	MarC family integral membrane protein
AV939_RS17960	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AV939_RS17965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AV939_RS17975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AV939_RS17990	COG0076	glutamate decarboxylase activity
AV939_RS17995	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AV939_RS18005	COG0842	Transport permease protein
AV939_RS18010	COG1131	(ABC) transporter
AV939_RS18015	COG0745	RESPONSE REGULATOR receiver
AV939_RS18020	COG2205	protein histidine kinase activity
AV939_RS18025	COG4774	siderophore transport
AV939_RS18045	COG1253	flavin adenine dinucleotide binding
AV939_RS18050	COG0701	Predicted permease
AV939_RS18055	COG1966	Carbon starvation protein
AV939_RS18070	COG0657	acetylesterase activity
AV939_RS18110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AV939_RS18115	COG0049	tRNA binding
AV939_RS18120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AV939_RS18125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AV939_RS18130	COG0085	RNA polymerase activity
AV939_RS18135	COG0222	ribosome binding
AV939_RS18140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AV939_RS18145	COG0081	regulation of translation
AV939_RS18150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AV939_RS18155	COG0250	Participates in transcription elongation, termination and antitermination
AV939_RS18160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AV939_RS18170	COG1132	(ABC) transporter
AV939_RS18175	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AV939_RS18180	COG3590	peptidase
AV939_RS18190	COG0513	Belongs to the DEAD box helicase family
AV939_RS18195	COG0418	dihydroorotase activity
AV939_RS18205	COG3040	lipid binding
AV939_RS18210	COG4989	oxidoreductase activity
AV939_RS18215	COG0346	lactoylglutathione lyase activity
AV939_RS18230	COG0302	gtp cyclohydrolase
AV939_RS18250	COG2957	Belongs to the agmatine deiminase family
AV939_RS18255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AV939_RS18270	COG3306	glycosyltransferase involved in LPS biosynthesis
AV939_RS18275	COG1201	RNA secondary structure unwinding
AV939_RS18285	COG1793	dna ligase
AV939_RS18295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AV939_RS18310	COG0625	glutathione transferase activity
AV939_RS18325	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AV939_RS18330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AV939_RS18340	COG1012	belongs to the aldehyde dehydrogenase family
AV939_RS18355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AV939_RS18360	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AV939_RS18365	COG0330	HflC and HflK could
AV939_RS18370	COG0330	HflC and HflK could
AV939_RS18375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AV939_RS18380	COG1923	regulation of RNA biosynthetic process
AV939_RS18385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AV939_RS18400	COG0802	atpase or kinase
AV939_RS18405	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AV939_RS18405	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AV939_RS18410	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AV939_RS18425	COG2816	NAD+ diphosphatase activity
AV939_RS18430	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AV939_RS18435	COG0735	belongs to the Fur family
AV939_RS18455	COG0305	Participates in initiation and elongation during chromosome replication
AV939_RS18480	COG2258	MOSC domain
AV939_RS18510	COG5002	protein histidine kinase activity
AV939_RS18520	COG0840	transmembrane signaling receptor activity
AV939_RS18525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AV939_RS18525	COG4191	Histidine kinase
AV939_RS18535	COG1609	Transcriptional regulator
AV939_RS18540	COG2211	Major facilitator Superfamily
AV939_RS18545	COG2723	6-phospho-beta-galactosidase activity
AV939_RS18555	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AV939_RS18560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AV939_RS18565	COG4558	Periplasmic binding protein
AV939_RS18575	COG4206	TonB-dependent receptor
AV939_RS18585	COG1472	Belongs to the glycosyl hydrolase 3 family
AV939_RS18600	COG2855	membrane
AV939_RS18605	COG2175	clavaminate synthase activity
AV939_RS18610	COG0656	L-ascorbic acid biosynthetic process
AV939_RS18615	COG2188	Transcriptional regulator
AV939_RS18630	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AV939_RS18635	COG1230	cation diffusion facilitator family transporter
AV939_RS18670	COG4771	TonB-dependent receptor
AV939_RS18675	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AV939_RS18680	COG4988	ABC transporter
AV939_RS18690	COG1294	oxidase, subunit
AV939_RS18705	COG2204	response regulator
AV939_RS18740	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AV939_RS18765	COG4319	ketosteroid isomerase
AV939_RS18805	COG3237	CsbD-like
AV939_RS18825	COG1404	Belongs to the peptidase S8 family
AV939_RS18850	COG2267	carboxylic ester hydrolase activity
AV939_RS18875	COG3038	cytochrome b561
AV939_RS18880	COG2353	YceI-like domain
AV939_RS18885	COG1252	NADH dehydrogenase
AV939_RS18915	COG2130	NADP-dependent
AV939_RS18920	COG5001	Diguanylate cyclase
AV939_RS18920	COG3706	GGDEF domain
AV939_RS18920	COG2203	Gaf domain
AV939_RS18920	COG4251	negative regulation of phosphorylation
AV939_RS18940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AV939_RS18950	COG4181	ATPase activity
AV939_RS18970	COG0523	cobalamin synthesis protein
AV939_RS18985	COG4771	TonB-dependent receptor
AV939_RS19015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AV939_RS19020	COG1349	DNA-binding transcription factor activity
AV939_RS19035	COG0697	spore germination
AV939_RS19040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AV939_RS19045	COG4977	sequence-specific DNA binding
AV939_RS19055	COG1166	arginine decarboxylase activity
AV939_RS19065	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AV939_RS19085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AV939_RS19095	COG0523	cobalamin synthesis protein
AV939_RS19125	COG4232	protein-disulfide reductase activity
AV939_RS19130	COG0739	heme binding
AV939_RS19135	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AV939_RS19140	COG0511	ligase activity, forming carbon-carbon bonds
AV939_RS19145	COG0439	Biotin carboxylase
AV939_RS19165	COG2176	DNA-directed DNA polymerase activity
AV939_RS19185	COG0154	amidase activity
AV939_RS19200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AV939_RS19205	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AV939_RS19220	COG0151	Belongs to the GarS family
AV939_RS19230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AV939_RS19240	COG3954	Phosphoribulokinase
AV939_RS19245	COG2233	PERMEase
AV939_RS19275	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AV939_RS19280	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AV939_RS19290	COG3031	protein transport across the cell outer membrane
AV939_RS19300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AV939_RS19305	COG1459	type II secretion system
AV939_RS19310	COG2165	general secretion pathway protein
AV939_RS19320	COG2165	general secretion pathway protein
AV939_RS19325	COG4795	General secretion pathway protein
AV939_RS19330	COG3156	type II secretion system protein K
AV939_RS19340	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AV939_RS19350	COG1234	tRNA 3'-trailer cleavage
AV939_RS19355	COG1012	belongs to the aldehyde dehydrogenase family
AV939_RS19365	COG1011	Hydrolase
AV939_RS19370	COG0494	nUDIX hydrolase
AV939_RS19375	COG1218	3'(2'),5'-bisphosphate nucleotidase
AV939_RS19385	COG2943	transferase activity, transferring hexosyl groups
AV939_RS19390	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AV939_RS19400	COG3089	Belongs to the UPF0270 family
AV939_RS19405	COG0429	hydrolase of the alpha beta-hydrolase fold
AV939_RS19415	COG0488	(ABC) transporter
AV939_RS19440	COG0545	Peptidyl-prolyl cis-trans isomerase
AV939_RS19450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AV939_RS19455	COG2183	response to ionizing radiation
AV939_RS19470	COG0596	Alpha beta hydrolase
AV939_RS19475	COG1040	competence protein
AV939_RS19495	COG1794	racemase activity, acting on amino acids and derivatives
AV939_RS19510	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AV939_RS19515	COG0534	Mate efflux family protein
AV939_RS19530	COG1999	signal sequence binding
AV939_RS19535	COG0109	protoheme IX farnesyltransferase activity
AV939_RS19540	COG1612	heme a metabolic process
AV939_RS19565	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AV939_RS19570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AV939_RS19575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AV939_RS19575	COG1565	acr, cog1565
AV939_RS19605	COG0129	dihydroxy-acid dehydratase activity
AV939_RS19620	COG0606	chelatase, subunit chli
AV939_RS19635	COG2814	Major facilitator Superfamily
AV939_RS19645	COG0729	surface antigen
AV939_RS19650	COG2911	Protein conserved in bacteria
AV939_RS19675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AV939_RS19685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AV939_RS19705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AV939_RS19755	COG0425	Belongs to the sulfur carrier protein TusA family
AV939_RS19770	COG1561	YicC-like family, N-terminal region
AV939_RS19805	COG2211	Major facilitator Superfamily
AV939_RS19810	COG1609	Transcriptional regulator
AV939_RS19825	COG2199	diguanylate cyclase activity
AV939_RS19825	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AV939_RS19855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AV939_RS19875	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AV939_RS19880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AV939_RS19900	COG1475	DNA binding
AV939_RS19905	COG1192	Involved in chromosome partitioning
AV939_RS19930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AV939_RS19935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AV939_RS19945	COG0706	membrane insertase activity
AV939_RS19950	COG0594	ribonuclease P activity
AV939_RS19955	COG0230	Belongs to the bacterial ribosomal protein bL34 family