locus-tag	class	description
DS731_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DS731_RS00045	COG2818	Glycosylase
DS731_RS00055	COG3078	GTPase activator activity
DS731_RS00075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DS731_RS00075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DS731_RS00080	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DS731_RS00085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DS731_RS00090	COG0569	domain protein
DS731_RS00095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DS731_RS00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DS731_RS00100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DS731_RS00110	COG1652	LysM domain
DS731_RS00115	COG0758	DNA mediated transformation
DS731_RS00125	COG0551	DNA topoisomerase type I activity
DS731_RS00130	COG0009	L-threonylcarbamoyladenylate synthase
DS731_RS00135	COG0408	coproporphyrinogen oxidase activity
DS731_RS00140	COG3047	cAMP biosynthetic process
DS731_RS00155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DS731_RS00205	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DS731_RS00210	COG0587	DNA-directed DNA polymerase activity
DS731_RS00250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DS731_RS00275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DS731_RS00310	COG0859	PFAM glycosyl transferase family 9
DS731_RS00330	COG0156	8-amino-7-oxononanoate synthase activity
DS731_RS00340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DS731_RS00355	COG3161	chorismate lyase activity
DS731_RS00360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DS731_RS00365	COG2960	long-chain fatty acid transporting porin activity
DS731_RS00370	COG0210	DNA helicase
DS731_RS00390	COG1216	Glycosyl transferase, family 2
DS731_RS00390	COG0463	Glycosyl transferase, family 2
DS731_RS00400	COG0438	transferase activity, transferring glycosyl groups
DS731_RS00400	COG0297	glycogen (starch) synthase activity
DS731_RS00405	COG2244	polysaccharide biosynthetic process
DS731_RS00470	COG0514	ATP-dependent DNA helicase (RecQ)
DS731_RS00515	COG0720	synthase
DS731_RS00595	COG0463	Glycosyl transferase, family 2
DS731_RS00600	COG2207	Transcriptional regulator
DS731_RS00615	COG4191	Histidine kinase
DS731_RS00615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_RS00625	COG0656	L-ascorbic acid biosynthetic process
DS731_RS00635	COG4771	TonB-dependent receptor
DS731_RS00640	COG3250	beta-galactosidase activity
DS731_RS00670	COG3250	beta-galactosidase activity
DS731_RS00690	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS00690	COG3347	Dehydrogenase
DS731_RS00695	COG4952	isomerase
DS731_RS00700	COG1304	FMN binding
DS731_RS00745	COG0531	amino acid
DS731_RS00765	COG1309	transcriptional regulator
DS731_RS00820	COG1609	Transcriptional regulator
DS731_RS00830	COG4771	TonB-dependent receptor
DS731_RS00845	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DS731_RS00850	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS00860	COG4771	TonB-dependent receptor
DS731_RS00865	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS00880	COG2814	Major facilitator Superfamily
DS731_RS00885	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS00895	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS00905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS731_RS00950	COG4771	TonB-dependent receptor
DS731_RS00960	COG4771	TonB-dependent receptor
DS731_RS00965	COG2272	Belongs to the type-B carboxylesterase lipase family
DS731_RS01000	COG2144	transferase activity, transferring acyl groups
DS731_RS01025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DS731_RS01030	COG0348	domain, Protein
DS731_RS01035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DS731_RS01040	COG1271	oxidase subunit
DS731_RS01045	COG1294	oxidase, subunit
DS731_RS01070	COG2814	Major facilitator Superfamily
DS731_RS01115	COG4771	TonB-dependent receptor
DS731_RS01120	COG0583	DNA-binding transcription factor activity
DS731_RS01140	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DS731_RS01160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS731_RS01165	COG4771	TonB-dependent receptor
DS731_RS01170	COG4774	siderophore transport
DS731_RS01180	COG3384	dioxygenase
DS731_RS01185	COG2814	Major facilitator Superfamily
DS731_RS01190	COG0583	DNA-binding transcription factor activity
DS731_RS01195	COG2211	Major facilitator Superfamily
DS731_RS01200	COG3622	Belongs to the hyi family
DS731_RS01205	COG1082	Xylose isomerase domain protein TIM barrel
DS731_RS01230	COG3119	arylsulfatase activity
DS731_RS01235	COG2186	Transcriptional regulator
DS731_RS01240	COG0840	transmembrane signaling receptor activity
DS731_RS01265	COG4773	Receptor
DS731_RS01280	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DS731_RS01295	COG1178	ABC-type Fe3 transport system permease component
DS731_RS01300	COG3842	ATPase activity
DS731_RS01360	COG5002	protein histidine kinase activity
DS731_RS01375	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
DS731_RS01380	COG0583	DNA-binding transcription factor activity
DS731_RS01385	COG0402	S-adenosylhomocysteine deaminase activity
DS731_RS01390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS731_RS01405	COG0179	Fumarylacetoacetate (FAA) hydrolase
DS731_RS01415	COG2205	protein histidine kinase activity
DS731_RS01420	COG0745	RESPONSE REGULATOR receiver
DS731_RS01425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_RS01430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS731_RS01455	COG3940	Belongs to the glycosyl hydrolase 43 family
DS731_RS01460	COG4206	TonB-dependent receptor
DS731_RS01480	COG0667	Aldo Keto reductase
DS731_RS01485	COG3507	Belongs to the glycosyl hydrolase 43 family
DS731_RS01495	COG3119	arylsulfatase activity
DS731_RS01525	COG1764	response to oxidative stress
DS731_RS01530	COG1846	Transcriptional regulator
DS731_RS01535	COG0840	transmembrane signaling receptor activity
DS731_RS01545	COG3177	Filamentation induced by cAMP protein fic
DS731_RS01550	COG0277	FAD linked oxidase domain protein
DS731_RS01555	COG3148	PFAM DTW domain containing protein
DS731_RS01575	COG1566	PFAM secretion protein HlyD family protein
DS731_RS01580	COG1289	transmembrane transporter activity
DS731_RS01585	COG1312	Catalyzes the dehydration of D-mannonate
DS731_RS01605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DS731_RS01610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DS731_RS01615	COG2971	BadF BadG BcrA BcrD
DS731_RS01625	COG1609	Transcriptional regulator
DS731_RS01640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DS731_RS01650	COG2610	gluconate transmembrane transporter activity
DS731_RS01655	COG3265	gluconokinase activity
DS731_RS01660	COG1609	Transcriptional regulator
DS731_RS01675	COG3106	COG3106 Predicted ATPase
DS731_RS01685	COG0668	transmembrane transport
DS731_RS01705	COG1192	Involved in chromosome partitioning
DS731_RS01730	COG0438	transferase activity, transferring glycosyl groups
DS731_RS01760	COG3123	guanosine phosphorylase activity
DS731_RS01790	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DS731_RS01795	COG4771	TonB-dependent receptor
DS731_RS01800	COG2755	lipolytic protein G-D-S-L family
DS731_RS01810	COG4771	TonB-dependent receptor
DS731_RS01830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DS731_RS01835	COG0800	Aldolase
DS731_RS01840	COG0246	Mannitol dehydrogenase
DS731_RS01845	COG1904	glucuronate isomerase
DS731_RS01850	COG2721	sulfolactate sulfo-lyase activity
DS731_RS01865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DS731_RS01875	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DS731_RS01880	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS01890	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DS731_RS01905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DS731_RS01910	COG0352	thiamine-phosphate diphosphorylase activity
DS731_RS01940	COG4771	TonB-dependent receptor
DS731_RS01945	COG0402	S-adenosylhomocysteine deaminase activity
DS731_RS01955	COG2959	enzyme of heme biosynthesis
DS731_RS01960	COG1587	Uroporphyrinogen-III synthase
DS731_RS01965	COG0181	hydroxymethylbilane synthase activity
DS731_RS01975	COG0194	GDP metabolic process
DS731_RS01985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DS731_RS02000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DS731_RS02010	COG0678	peroxiredoxin activity
DS731_RS02015	COG2197	response regulator
DS731_RS02020	COG2081	HI0933 family
DS731_RS02040	COG2832	Protein of unknown function (DUF454)
DS731_RS02045	COG0484	heat shock protein binding
DS731_RS02050	COG1309	transcriptional regulator
DS731_RS02055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_RS02065	COG0427	acetyl-CoA hydrolase
DS731_RS02070	COG0123	including yeast histone deacetylase and acetoin utilization protein
DS731_RS02080	COG0840	transmembrane signaling receptor activity
DS731_RS02100	COG3064	Membrane
DS731_RS02110	COG5001	Diguanylate cyclase
DS731_RS02110	COG5002	protein histidine kinase activity
DS731_RS02120	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DS731_RS02135	COG2239	Acts as a magnesium transporter
DS731_RS02140	COG2962	Rard protein
DS731_RS02145	COG3706	GGDEF domain
DS731_RS02150	COG0210	DNA helicase
DS731_RS02160	COG1295	ribonuclease BN
DS731_RS02165	COG3237	CsbD-like
DS731_RS02175	COG1011	Hydrolase
DS731_RS02180	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DS731_RS02190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DS731_RS02195	COG0019	diaminopimelate decarboxylase activity
DS731_RS02210	COG0671	phosphoesterase, PA-phosphatase related
DS731_RS02225	COG0163	prenyltransferase activity
DS731_RS02230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DS731_RS02240	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DS731_RS02245	COG4191	Histidine kinase
DS731_RS02250	COG0840	transmembrane signaling receptor activity
DS731_RS02260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DS731_RS02265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DS731_RS02275	COG3292	Two component regulator propeller
DS731_RS02275	COG2205	protein histidine kinase activity
DS731_RS02275	COG0745	RESPONSE REGULATOR receiver
DS731_RS02280	COG0583	DNA-binding transcription factor activity
DS731_RS02295	COG0004	ammonium transporteR
DS731_RS02300	COG0697	spore germination
DS731_RS02305	COG0583	DNA-binding transcription factor activity
DS731_RS02330	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DS731_RS02340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DS731_RS02360	COG0089	rRNA binding
DS731_RS02370	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DS731_RS02380	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DS731_RS02395	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DS731_RS02405	COG2258	MOSC domain
DS731_RS02435	COG0432	Pfam Uncharacterised protein family UPF0047
DS731_RS02445	COG0735	belongs to the Fur family
DS731_RS02465	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DS731_RS02465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DS731_RS02470	COG0802	atpase or kinase
DS731_RS02485	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DS731_RS02490	COG1923	regulation of RNA biosynthetic process
DS731_RS02495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DS731_RS02500	COG0330	HflC and HflK could
DS731_RS02505	COG0330	HflC and HflK could
DS731_RS02510	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DS731_RS02515	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DS731_RS02530	COG1012	belongs to the aldehyde dehydrogenase family
DS731_RS02535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DS731_RS02545	COG0557	exoribonuclease II activity
DS731_RS02550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DS731_RS02555	COG4206	TonB-dependent receptor
DS731_RS02565	COG0784	Response regulator, receiver
DS731_RS02565	COG2205	protein histidine kinase activity
DS731_RS02600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DS731_RS02615	COG0200	Binds to the 23S rRNA
DS731_RS02620	COG0201	protein transport
DS731_RS02645	COG0202	RNA polymerase activity
DS731_RS02695	COG1216	Glycosyl transferase, family 2
DS731_RS02695	COG1442	glycosyl transferase family 8
DS731_RS02705	COG0463	Glycosyl transferase, family 2
DS731_RS02735	COG1216	Glycosyl transferase, family 2
DS731_RS02735	COG0438	transferase activity, transferring glycosyl groups
DS731_RS02775	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DS731_RS02785	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DS731_RS02825	COG3706	GGDEF domain
DS731_RS02830	COG1966	Carbon starvation protein
DS731_RS02835	COG1253	flavin adenine dinucleotide binding
DS731_RS02840	COG2205	protein histidine kinase activity
DS731_RS02845	COG0745	RESPONSE REGULATOR receiver
DS731_RS02855	COG1131	(ABC) transporter
DS731_RS02860	COG0842	Transport permease protein
DS731_RS02865	COG4106	trans-aconitate 2-methyltransferase activity
DS731_RS02875	COG0076	glutamate decarboxylase activity
DS731_RS02890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DS731_RS02895	COG0617	tRNA 3'-terminal CCA addition
DS731_RS02905	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DS731_RS02925	COG2095	MarC family integral membrane protein
DS731_RS02930	COG3068	Protein conserved in bacteria
DS731_RS02935	COG0742	ribosomal rna small subunit methyltransferase
DS731_RS02940	COG0552	protein localization to endoplasmic reticulum
DS731_RS02945	COG2884	Cell division ATP-binding protein ftsE
DS731_RS02950	COG2177	Part of the ABC transporter FtsEX involved in
DS731_RS02955	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DS731_RS02960	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DS731_RS02975	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DS731_RS02985	COG0456	acetyltransferase
DS731_RS03015	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DS731_RS03025	COG2814	Major facilitator Superfamily
DS731_RS03030	COG0281	malic enzyme
DS731_RS03040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DS731_RS03055	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DS731_RS03065	COG0583	DNA-binding transcription factor activity
DS731_RS03070	COG1902	pentaerythritol trinitrate reductase activity
DS731_RS03090	COG2197	response regulator
DS731_RS03100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_RS03130	COG1335	isochorismatase
DS731_RS03135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DS731_RS03145	COG5290	Psort location Cytoplasmic, score
DS731_RS03205	COG0789	Transcriptional regulator
DS731_RS03210	COG4977	sequence-specific DNA binding
DS731_RS03235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DS731_RS03240	COG4191	Histidine kinase
DS731_RS03240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_RS03260	COG2201	protein-glutamate methylesterase activity
DS731_RS03270	COG0339	signal peptide processing
DS731_RS03290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DS731_RS03295	COG1278	Cold shock
DS731_RS03310	COG0183	Belongs to the thiolase family
DS731_RS03315	COG1024	Enoyl-CoA hydratase
DS731_RS03315	COG1250	3-hydroxyacyl-CoA dehydrogenase
DS731_RS03325	COG0006	proline dipeptidase activity
DS731_RS03335	COG0142	geranyltranstransferase activity
DS731_RS03370	COG1238	metal cluster binding
DS731_RS03380	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DS731_RS03385	COG0585	pseudouridine synthase activity
DS731_RS03400	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DS731_RS03410	COG0840	transmembrane signaling receptor activity
DS731_RS03425	COG3025	triphosphatase activity
DS731_RS03435	COG3066	DNA modification
DS731_RS03440	COG0494	nUDIX hydrolase
DS731_RS03455	COG0730	response to heat
DS731_RS03460	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DS731_RS03465	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DS731_RS03470	COG2201	protein-glutamate methylesterase activity
DS731_RS03475	COG3706	GGDEF domain
DS731_RS03480	COG2205	protein histidine kinase activity
DS731_RS03480	COG0784	Response regulator, receiver
DS731_RS03500	COG0564	pseudouridine synthase activity
DS731_RS03510	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DS731_RS03520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DS731_RS03520	COG1648	precorrin-2 dehydrogenase activity
DS731_RS03540	COG1538	Outer membrane efflux protein
DS731_RS03545	COG0494	nUDIX hydrolase
DS731_RS03550	COG3151	Protein conserved in bacteria
DS731_RS03555	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DS731_RS03560	COG3150	esterase
DS731_RS03575	COG1280	lysine exporter protein (LysE YggA)
DS731_RS03580	COG2153	protein acetylation
DS731_RS03585	COG4191	Histidine kinase
DS731_RS03585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_RS03595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DS731_RS03615	COG1509	lysine 2,3-aminomutase activity
DS731_RS03620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DS731_RS03625	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DS731_RS03630	COG4771	TonB-dependent receptor
DS731_RS03635	COG0519	Catalyzes the synthesis of GMP from XMP
DS731_RS03655	COG0271	Belongs to the BolA IbaG family
DS731_RS03670	COG0679	Auxin Efflux Carrier
DS731_RS03675	COG0671	phosphoesterase, PA-phosphatase related
DS731_RS03680	COG3707	response regulator
DS731_RS03685	COG2116	formate transmembrane transporter activity
DS731_RS03690	COG0515	serine threonine protein kinase
DS731_RS03690	COG2815	serine threonine protein kinase
DS731_RS03695	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
DS731_RS03710	COG1764	response to oxidative stress
DS731_RS03715	COG0659	secondary active sulfate transmembrane transporter activity
DS731_RS03720	COG2146	nitrite reductase [NAD(P)H] activity
DS731_RS03720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DS731_RS03725	COG2146	nitrite reductase [NAD(P)H] activity
DS731_RS03730	COG0243	molybdopterin cofactor binding
DS731_RS03735	COG1648	precorrin-2 dehydrogenase activity
DS731_RS03735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DS731_RS03740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DS731_RS03750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DS731_RS03750	COG1116	anion transmembrane transporter activity
DS731_RS03755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DS731_RS03760	COG1116	anion transmembrane transporter activity
DS731_RS03770	COG0746	molybdenum cofactor guanylyltransferase activity
DS731_RS03785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DS731_RS03790	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DS731_RS03815	COG2356	endonuclease I
DS731_RS03820	COG1960	acyl-CoA dehydrogenase activity
DS731_RS03840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DS731_RS03845	COG0569	domain protein
DS731_RS03850	COG4948	Mandelate Racemase Muconate Lactonizing
DS731_RS03865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_RS03870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS731_RS03875	COG0500	methyltransferase
DS731_RS03880	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS731_RS03890	COG2223	nitrite transmembrane transporter activity
DS731_RS03895	COG4172	Belongs to the ABC transporter superfamily
DS731_RS03900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DS731_RS03905	COG0601	transmembrane transport
DS731_RS03910	COG0747	negative chemotaxis
DS731_RS03915	COG0656	L-ascorbic acid biosynthetic process
DS731_RS03925	COG4948	Mandelate Racemase Muconate Lactonizing
DS731_RS03935	COG0583	DNA-binding transcription factor activity
DS731_RS03940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DS731_RS03945	COG0358	DNA primase activity
DS731_RS03950	COG1610	YqeY-like protein
DS731_RS03975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DS731_RS03995	COG0537	adenosine 5'-monophosphoramidase activity
DS731_RS04020	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DS731_RS04025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DS731_RS04030	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DS731_RS04035	COG1492	cobalamin metabolic process
DS731_RS04050	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DS731_RS04055	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DS731_RS04060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DS731_RS04065	COG1120	ATPase activity
DS731_RS04075	COG3135	benzoate transporter
DS731_RS04080	COG2974	May be involved in recombination
DS731_RS04085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_RS04085	COG4191	Histidine kinase
DS731_RS04090	COG0745	RESPONSE REGULATOR receiver
DS731_RS04095	COG5002	protein histidine kinase activity
DS731_RS04120	COG0811	peptide transport
DS731_RS04125	COG0811	peptide transport
DS731_RS04130	COG0848	biopolymer transport protein
DS731_RS04135	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DS731_RS04160	COG0784	Response regulator, receiver
DS731_RS04160	COG2205	protein histidine kinase activity
DS731_RS04160	COG5002	protein histidine kinase activity
DS731_RS04175	COG2133	pyrroloquinoline quinone binding
DS731_RS04190	COG0527	aspartate kinase activity
DS731_RS04195	COG2207	Transcriptional regulator
DS731_RS04205	COG5001	Diguanylate cyclase
DS731_RS04205	COG3706	GGDEF domain
DS731_RS04205	COG2203	Gaf domain
DS731_RS04205	COG4251	negative regulation of phosphorylation
DS731_RS04210	COG0840	transmembrane signaling receptor activity
DS731_RS04215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DS731_RS04220	COG2967	ApaG domain
DS731_RS04230	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DS731_RS04235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DS731_RS04240	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DS731_RS04245	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DS731_RS04250	COG4974	Belongs to the 'phage' integrase family
DS731_RS04265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DS731_RS04285	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DS731_RS04290	COG0736	holo-[acyl-carrier-protein] synthase activity
DS731_RS04295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DS731_RS04300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DS731_RS04305	COG3956	TIGRFAM MazG family protein
DS731_RS04320	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DS731_RS04325	COG1473	amidohydrolase
DS731_RS04330	COG0723	plastoquinol--plastocyanin reductase activity
DS731_RS04335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DS731_RS04340	COG2857	Cytochrome c1
DS731_RS04345	COG0625	glutathione transferase activity
DS731_RS04350	COG2969	positive regulation of protein catabolic process
DS731_RS04365	COG0745	RESPONSE REGULATOR receiver
DS731_RS04370	COG2239	Acts as a magnesium transporter
DS731_RS04390	COG4682	membrane
DS731_RS04400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DS731_RS04420	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DS731_RS04425	COG1137	ATPase activity
DS731_RS04440	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DS731_RS04460	COG1127	ABC transporter
DS731_RS04465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DS731_RS04470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DS731_RS04475	COG2854	intermembrane phospholipid transfer
DS731_RS04485	COG5007	Belongs to the BolA IbaG family
DS731_RS04495	COG2205	protein histidine kinase activity
DS731_RS04500	COG0745	RESPONSE REGULATOR receiver
DS731_RS04515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DS731_RS04520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DS731_RS04530	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DS731_RS04595	COG1132	(ABC) transporter
DS731_RS04635	COG2205	protein histidine kinase activity
DS731_RS04635	COG0784	Response regulator, receiver
DS731_RS04650	COG1794	racemase activity, acting on amino acids and derivatives
DS731_RS04665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DS731_RS04675	COG0126	phosphoglycerate kinase activity
DS731_RS04680	COG3588	fructose-bisphosphate aldolase
DS731_RS04695	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DS731_RS04705	COG0573	inorganic phosphate transmembrane transporter activity
DS731_RS04725	COG0306	phosphate transporter
DS731_RS04730	COG0589	response to stress
DS731_RS04755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DS731_RS04770	COG0489	protein tyrosine kinase activity
DS731_RS04830	COG0121	glutamine amidotransferase
DS731_RS04850	COG1272	protein, Hemolysin III
DS731_RS04865	COG1846	Transcriptional regulator
DS731_RS04870	COG0154	amidase activity
DS731_RS04890	COG4638	Rieske (2fe-2S)
DS731_RS04900	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS04905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DS731_RS04910	COG1942	4-Oxalocrotonate Tautomerase
DS731_RS04915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DS731_RS04920	COG1473	amidohydrolase
DS731_RS04940	COG2271	Major facilitator Superfamily
DS731_RS04955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DS731_RS04960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DS731_RS04965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DS731_RS04965	COG1017	nitric oxide dioxygenase activity
DS731_RS04970	COG3604	Transcriptional regulator
DS731_RS04980	COG2801	Transposase and inactivated derivatives
DS731_RS05000	COG3321	synthase
DS731_RS05000	COG4221	oxidoreductase activity
DS731_RS05000	COG0604	alcohol dehydrogenase
DS731_RS05000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS731_RS05005	COG4221	oxidoreductase activity
DS731_RS05010	COG0583	DNA-binding transcription factor activity
DS731_RS05015	COG1739	Uncharacterized protein family UPF0029
DS731_RS05030	COG5001	Diguanylate cyclase
DS731_RS05030	COG3300	MHYT domain
DS731_RS05050	COG2885	chlorophyll binding
DS731_RS05070	COG0745	RESPONSE REGULATOR receiver
DS731_RS05070	COG2205	protein histidine kinase activity
DS731_RS05070	COG4191	Histidine kinase
DS731_RS05075	COG0784	Response regulator, receiver
DS731_RS05075	COG3437	response regulator, receiver
DS731_RS05080	COG4191	Histidine kinase
DS731_RS05080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_RS05085	COG2200	EAL domain
DS731_RS05085	COG2203	Gaf domain
DS731_RS05085	COG2199	diguanylate cyclase activity
DS731_RS05095	COG0420	3'-5' exonuclease activity
DS731_RS05100	COG0419	ATPase involved in DNA repair
DS731_RS05140	COG0701	Predicted permease
DS731_RS05145	COG0789	Transcriptional regulator
DS731_RS05160	COG2205	protein histidine kinase activity
DS731_RS05170	COG0488	(ABC) transporter
DS731_RS05185	COG1451	nucleotide metabolic process
DS731_RS05195	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DS731_RS05210	COG5002	protein histidine kinase activity
DS731_RS05215	COG1472	Belongs to the glycosyl hydrolase 3 family
DS731_RS05220	COG2723	6-phospho-beta-galactosidase activity
DS731_RS05230	COG0477	Major facilitator Superfamily
DS731_RS05230	COG2814	Major facilitator Superfamily
DS731_RS05265	COG2851	Citrate transporter
DS731_RS05275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DS731_RS05285	COG0583	DNA-binding transcription factor activity
DS731_RS05330	COG4774	siderophore transport
DS731_RS05410	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS731_RS05430	COG0789	Transcriptional regulator
DS731_RS05435	COG2217	Heavy metal translocating P-type atpase
DS731_RS05470	COG0531	amino acid
DS731_RS05480	COG2132	Multicopper oxidase
DS731_RS05505	COG0583	DNA-binding transcription factor activity
DS731_RS05510	COG4948	Mandelate Racemase Muconate Lactonizing
DS731_RS05515	COG3485	protocatechuate 3,4-dioxygenase
DS731_RS05540	COG3135	benzoate transporter
DS731_RS05545	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DS731_RS05585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DS731_RS05590	COG0183	Belongs to the thiolase family
DS731_RS05595	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DS731_RS05600	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DS731_RS05605	COG1414	Transcriptional regulator
DS731_RS05610	COG4948	Mandelate Racemase Muconate Lactonizing
DS731_RS05625	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DS731_RS05635	COG3284	Transcriptional regulator
DS731_RS05660	COG0596	Alpha beta hydrolase
DS731_RS05670	COG0179	Fumarylacetoacetate (FAA) hydrolase
DS731_RS05685	COG0477	Major facilitator Superfamily
DS731_RS05695	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DS731_RS05700	COG4774	siderophore transport
DS731_RS05705	COG2211	Major facilitator Superfamily
DS731_RS05755	COG1380	Effector of murein hydrolase LrgA
DS731_RS05760	COG1346	cytolysis
DS731_RS05790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DS731_RS05800	COG0513	Belongs to the DEAD box helicase family
DS731_RS05805	COG0514	ATP-dependent DNA helicase (RecQ)
DS731_RS05820	COG3267	Type II secretory pathway component ExeA
DS731_RS05820	COG3409	Peptidoglycan-binding domain 1 protein
DS731_RS05845	COG0473	3-isopropylmalate dehydrogenase activity
DS731_RS05850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DS731_RS05900	COG4133	protoheme IX ABC transporter activity
DS731_RS05905	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DS731_RS05910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DS731_RS05915	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DS731_RS05925	COG1138	Cytochrome C-type biogenesis protein
DS731_RS05930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DS731_RS05935	COG4235	cytochrome complex assembly
DS731_RS05935	COG3088	subunit of a heme lyase
DS731_RS05950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DS731_RS05960	COG3104	oligopeptide transport
DS731_RS05995	COG1216	Glycosyl transferase, family 2
DS731_RS06005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DS731_RS06010	COG1555	photosystem II stabilization
DS731_RS06010	COG1596	polysaccharide export
DS731_RS06015	COG0473	3-isopropylmalate dehydrogenase activity
DS731_RS06030	COG1611	Belongs to the LOG family
DS731_RS06040	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DS731_RS06040	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DS731_RS06095	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DS731_RS06100	COG0024	Methionine aminopeptidase
DS731_RS06110	COG0052	Belongs to the universal ribosomal protein uS2 family
DS731_RS06120	COG0528	UMP kinase activity
DS731_RS06130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DS731_RS06135	COG0575	Belongs to the CDS family
DS731_RS06140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DS731_RS06145	COG0750	zinc metalloprotease
DS731_RS06160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DS731_RS06165	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DS731_RS06180	COG0587	DNA-directed DNA polymerase activity
DS731_RS06185	COG0825	malonyl-CoA metabolic process
DS731_RS06190	COG0037	tRNA processing
DS731_RS06215	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DS731_RS06220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DS731_RS06220	COG0047	phosphoribosylformylglycinamidine synthase activity
DS731_RS06260	COG0784	Response regulator, receiver
DS731_RS06260	COG0835	chemotaxis
DS731_RS06265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DS731_RS06270	COG1815	bacterial-type flagellum-dependent cell motility
DS731_RS06280	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DS731_RS06290	COG4786	Flagellar basal body rod
DS731_RS06310	COG1705	Flagellar rod assembly protein muramidase FlgJ
DS731_RS06310	COG3951	Flagellar rod assembly protein muramidase FlgJ
DS731_RS06340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DS731_RS06365	COG1086	Polysaccharide biosynthesis protein
DS731_RS06370	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DS731_RS06375	COG1083	cytidylyl-transferase
DS731_RS06385	COG2089	acid synthase
DS731_RS06405	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS06455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DS731_RS06460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DS731_RS06470	COG2226	methyltransferase
DS731_RS06475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DS731_RS06480	COG0022	dehydrogenase e1 component
DS731_RS06490	COG0028	Belongs to the TPP enzyme family
DS731_RS06500	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DS731_RS06505	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DS731_RS06505	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DS731_RS06515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DS731_RS06535	COG1677	Flagellar hook-basal body complex protein FliE
DS731_RS06540	COG1766	The M ring may be actively involved in energy transduction
DS731_RS06545	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DS731_RS06595	COG1987	bacterial-type flagellum assembly
DS731_RS06615	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DS731_RS06640	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DS731_RS06645	COG2198	Histidine kinase
DS731_RS06645	COG0784	Response regulator, receiver
DS731_RS06645	COG0643	Histidine kinase
DS731_RS06650	COG2201	protein-glutamate methylesterase activity
DS731_RS06655	COG1192	Involved in chromosome partitioning
DS731_RS06665	COG0835	chemotaxis
DS731_RS06675	COG1522	sequence-specific DNA binding
DS731_RS06690	COG1410	methionine synthase
DS731_RS06690	COG0646	methionine synthase
DS731_RS06715	COG0583	DNA-binding transcription factor activity
DS731_RS06730	COG0659	secondary active sulfate transmembrane transporter activity
DS731_RS06735	COG0288	reversible hydration of carbon dioxide
DS731_RS06740	COG0659	secondary active sulfate transmembrane transporter activity
DS731_RS06745	COG4771	TonB-dependent receptor
DS731_RS06755	COG3590	peptidase
DS731_RS06765	COG2137	regulation of response to DNA damage stimulus
DS731_RS06770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DS731_RS06800	COG0642	Histidine kinase
DS731_RS06845	COG3630	sodium ion export across plasma membrane
DS731_RS06855	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DS731_RS06860	COG4172	Belongs to the ABC transporter superfamily
DS731_RS06865	COG4172	Belongs to the ABC transporter superfamily
DS731_RS06870	COG4171	peptide transport system, permease
DS731_RS06875	COG4168	peptide transport system, permease
DS731_RS06880	COG0747	negative chemotaxis
DS731_RS06885	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DS731_RS06890	COG1842	Phage shock protein A
DS731_RS06920	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DS731_RS06930	COG0625	glutathione transferase activity
DS731_RS06935	COG1522	sequence-specific DNA binding
DS731_RS06980	COG0811	peptide transport
DS731_RS06985	COG0811	peptide transport
DS731_RS06990	COG0848	biopolymer transport protein
DS731_RS07055	COG0456	acetyltransferase
DS731_RS07070	COG0583	DNA-binding transcription factor activity
DS731_RS07075	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS07085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DS731_RS07090	COG2116	formate transmembrane transporter activity
DS731_RS07100	COG0564	pseudouridine synthase activity
DS731_RS07110	COG0612	Peptidase, M16
DS731_RS07115	COG2918	glutathione biosynthetic process
DS731_RS07130	COG2840	Smr protein MutS2
DS731_RS07135	COG2890	protein-(glutamine-N5) methyltransferase activity
DS731_RS07155	COG2719	SpoVR family
DS731_RS07165	COG2766	serine protein kinase
DS731_RS07170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DS731_RS07175	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DS731_RS07180	COG4771	TonB-dependent receptor
DS731_RS07205	COG0450	alkyl hydroperoxide reductase
DS731_RS07210	COG2814	Major facilitator Superfamily
DS731_RS07210	COG0477	Major facilitator Superfamily
DS731_RS07225	COG0584	glycerophosphoryl diester phosphodiesterase
DS731_RS07240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DS731_RS07245	COG4660	Part of a membrane complex involved in electron transport
DS731_RS07250	COG4659	FMN binding
DS731_RS07255	COG4658	electron transport chain
DS731_RS07260	COG4656	Part of a membrane complex involved in electron transport
DS731_RS07265	COG2878	Part of a membrane complex involved in electron transport
DS731_RS07270	COG4657	Part of a membrane complex involved in electron transport
DS731_RS07290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DS731_RS07430	COG4974	Belongs to the 'phage' integrase family
DS731_RS07455	COG0629	single-stranded DNA binding
DS731_RS07550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DS731_RS07565	COG0534	Mate efflux family protein
DS731_RS07570	COG0556	nucleotide-excision repair
DS731_RS07585	COG0602	queuosine metabolic process
DS731_RS07595	COG0367	asparagine synthase
DS731_RS07615	COG4555	ABC transporter
DS731_RS07620	COG1668	transmembrane transport
DS731_RS07625	COG3273	potassium ion transport
DS731_RS07625	COG0471	metal ion transport
DS731_RS07640	COG0529	Catalyzes the synthesis of activated sulfate
DS731_RS07645	COG0175	sulfate reduction
DS731_RS07650	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS731_RS07660	COG1595	DNA-templated transcription, initiation
DS731_RS07675	COG2304	oxidoreductase activity
DS731_RS07695	COG0714	Associated with various cellular activities
DS731_RS07705	COG1024	Enoyl-CoA hydratase
DS731_RS07705	COG1250	3-hydroxyacyl-CoA dehydrogenase
DS731_RS07735	COG4536	flavin adenine dinucleotide binding
DS731_RS07740	COG4137	Cytochrome C assembly protein
DS731_RS07745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DS731_RS07780	COG1132	(ABC) transporter
DS731_RS07785	COG2204	response regulator
DS731_RS07795	COG2204	response regulator
DS731_RS07800	COG0228	four-way junction DNA binding
DS731_RS07805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DS731_RS07810	COG0336	Belongs to the RNA methyltransferase TrmD family
DS731_RS07815	COG0335	large ribosomal subunit rRNA binding
DS731_RS07820	COG2197	response regulator
DS731_RS07825	COG4585	Histidine kinase
DS731_RS07845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DS731_RS07850	COG0287	Prephenate dehydrogenase
DS731_RS07850	COG1605	Chorismate mutase
DS731_RS07880	COG1605	Chorismate mutase
DS731_RS07880	COG0077	Prephenate dehydratase
DS731_RS07885	COG0745	RESPONSE REGULATOR receiver
DS731_RS07890	COG0023	Translation Initiation Factor
DS731_RS07920	COG2205	protein histidine kinase activity
DS731_RS07930	COG2204	response regulator
DS731_RS07940	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DS731_RS07945	COG0494	nUDIX hydrolase
DS731_RS07950	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DS731_RS07955	COG0632	four-way junction helicase activity
DS731_RS07960	COG2255	four-way junction helicase activity
DS731_RS07965	COG0824	Thioesterase
DS731_RS07970	COG0811	peptide transport
DS731_RS07985	COG0823	Involved in the tonB-independent uptake of proteins
DS731_RS07990	COG2885	chlorophyll binding
DS731_RS07995	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
DS731_RS08010	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DS731_RS08040	COG0457	Tetratricopeptide repeat
DS731_RS08045	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DS731_RS08055	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DS731_RS08080	COG3706	GGDEF domain
DS731_RS08090	COG3008	intermembrane lipid transfer
DS731_RS08090	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DS731_RS08095	COG2995	paraquat-inducible protein a
DS731_RS08100	COG0017	Asparaginyl-tRNA synthetase
DS731_RS08115	COG0189	ligase activity
DS731_RS08150	COG0156	8-amino-7-oxononanoate synthase activity
DS731_RS08155	COG2226	methyltransferase
DS731_RS08155	COG1073	alpha beta
DS731_RS08165	COG3340	Belongs to the peptidase S51 family
DS731_RS08175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS731_RS08180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DS731_RS08185	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS08190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DS731_RS08195	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DS731_RS08220	COG5265	(ABC) transporter
DS731_RS08225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DS731_RS08260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DS731_RS08300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DS731_RS08305	COG0402	S-adenosylhomocysteine deaminase activity
DS731_RS08310	COG0402	S-adenosylhomocysteine deaminase activity
DS731_RS08320	COG4181	ATPase activity
DS731_RS08325	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DS731_RS08335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_RS08340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS731_RS08360	COG1396	sequence-specific DNA binding
DS731_RS08370	COG1090	epimerase
DS731_RS08375	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DS731_RS08380	COG0628	permease
DS731_RS08385	COG0243	molybdopterin cofactor binding
DS731_RS08390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DS731_RS08400	COG1049	propionate catabolic process, 2-methylcitrate cycle
DS731_RS08425	COG2350	Protein conserved in bacteria
DS731_RS08440	COG0134	indole-3-glycerol-phosphate synthase activity
DS731_RS08440	COG0135	phosphoribosylanthranilate isomerase activity
DS731_RS08445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DS731_RS08450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DS731_RS08450	COG0512	Glutamine amidotransferase of anthranilate synthase
DS731_RS08455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DS731_RS08465	COG0009	L-threonylcarbamoyladenylate synthase
DS731_RS08475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DS731_RS08480	COG1187	pseudouridine synthase activity
DS731_RS08490	COG0656	L-ascorbic acid biosynthetic process
DS731_RS08495	COG2733	membrane
DS731_RS08510	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DS731_RS08515	COG0497	DNA recombination
DS731_RS08520	COG2814	Major facilitator Superfamily
DS731_RS08520	COG0477	Major facilitator Superfamily
DS731_RS08540	COG1846	Transcriptional regulator
DS731_RS08540	COG1940	carbohydrate kinase activity
DS731_RS08570	COG0384	phenazine biosynthesis protein PhzF
DS731_RS08600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DS731_RS08605	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS08615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DS731_RS08620	COG2610	gluconate transmembrane transporter activity
DS731_RS08635	COG0784	Response regulator, receiver
DS731_RS08635	COG2205	protein histidine kinase activity
DS731_RS08635	COG2198	Histidine kinase
DS731_RS08640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DS731_RS08650	COG0484	heat shock protein binding
DS731_RS08655	COG2801	Transposase and inactivated derivatives
DS731_RS08660	COG2963	transposase activity
DS731_RS08665	COG0784	Response regulator, receiver
DS731_RS08665	COG3437	response regulator, receiver
DS731_RS08670	COG4191	Histidine kinase
DS731_RS08670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_RS08680	COG3401	FG-GAP repeat protein
DS731_RS08700	COG3290	protein histidine kinase activity
DS731_RS08755	COG0583	DNA-binding transcription factor activity
DS731_RS08760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DS731_RS08765	COG2828	Protein conserved in bacteria
DS731_RS08770	COG2159	amidohydrolase
DS731_RS08825	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DS731_RS08845	COG0745	RESPONSE REGULATOR receiver
DS731_RS08845	COG4566	intracellular signal transduction
DS731_RS08860	COG2823	Periplasmic or secreted lipoprotein
DS731_RS08870	COG2853	Lipoprotein
DS731_RS08895	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DS731_RS08905	COG2165	general secretion pathway protein
DS731_RS08930	COG0784	Response regulator, receiver
DS731_RS08930	COG2198	Histidine kinase
DS731_RS08930	COG5002	protein histidine kinase activity
DS731_RS08935	COG0784	Response regulator, receiver
DS731_RS08940	COG4251	negative regulation of phosphorylation
DS731_RS08950	COG2204	response regulator
DS731_RS08960	COG0583	DNA-binding transcription factor activity
DS731_RS08970	COG0640	Transcriptional regulator
DS731_RS08985	COG0583	DNA-binding transcription factor activity
DS731_RS09015	COG5001	Diguanylate cyclase
DS731_RS09015	COG3300	MHYT domain
DS731_RS09030	COG1022	Amp-dependent synthetase and ligase
DS731_RS09045	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DS731_RS09050	COG1074	ATP-dependent DNA helicase activity
DS731_RS09055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DS731_RS09075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DS731_RS09080	COG0521	Mo-molybdopterin cofactor biosynthetic process
DS731_RS09085	COG0315	cyclic pyranopterin monophosphate synthase activity
DS731_RS09090	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DS731_RS09095	COG0314	molybdopterin synthase activity
DS731_RS09110	COG1618	nucleotide phosphatase activity, acting on free nucleotides
DS731_RS09110	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DS731_RS09120	COG4771	TonB-dependent receptor
DS731_RS09155	COG5002	protein histidine kinase activity
DS731_RS09155	COG0784	Response regulator, receiver
DS731_RS09155	COG2198	Histidine kinase
DS731_RS09160	COG3437	response regulator, receiver
DS731_RS09170	COG0195	Participates in both transcription termination and antitermination
DS731_RS09185	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DS731_RS09200	COG3153	acetyltransferase
DS731_RS09200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DS731_RS09240	COG1309	transcriptional regulator
DS731_RS09245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_RS09265	COG1032	radical SAM domain protein
DS731_RS09280	COG1228	amidohydrolase
DS731_RS09285	COG3706	GGDEF domain
DS731_RS09285	COG2203	Gaf domain
DS731_RS09285	COG5001	Diguanylate cyclase
DS731_RS09285	COG4251	negative regulation of phosphorylation
DS731_RS09295	COG1187	pseudouridine synthase activity
DS731_RS09350	COG0582	viral genome integration into host DNA
DS731_RS09385	COG4628	conserved protein (DUF2132)
DS731_RS09390	COG0446	pyridine nucleotide-disulphide oxidoreductase
DS731_RS09390	COG1902	pentaerythritol trinitrate reductase activity
DS731_RS09400	COG2867	negative regulation of translational initiation
DS731_RS09405	COG2914	Belongs to the UPF0125 (RnfH) family
DS731_RS09415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DS731_RS09425	COG0457	Tetratricopeptide repeat
DS731_RS09435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DS731_RS09435	COG0574	Belongs to the PEP-utilizing enzyme family
DS731_RS09455	COG2850	peptidyl-arginine hydroxylation
DS731_RS09465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DS731_RS09470	COG2915	High frequency lysogenization protein hflD homolog
DS731_RS09475	COG0482	sulfurtransferase activity
DS731_RS09480	COG1187	pseudouridine synthase activity
DS731_RS09490	COG1278	Cold shock
DS731_RS09495	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DS731_RS09500	COG0542	response to heat
DS731_RS09505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DS731_RS09510	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DS731_RS09515	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DS731_RS09520	COG0492	ferredoxin-NADP+ reductase activity
DS731_RS09525	COG3092	negative regulation of chromosome organization
DS731_RS09535	COG0616	signal peptide processing
DS731_RS09540	COG0778	Nitroreductase
DS731_RS09545	COG0469	pyruvate kinase activity
DS731_RS09550	COG1737	Transcriptional regulator
DS731_RS09555	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DS731_RS09565	COG0129	dihydroxy-acid dehydratase activity
DS731_RS09575	COG0800	Aldolase
DS731_RS09590	COG0676	glucose-6-phosphate 1-epimerase activity
DS731_RS09600	COG1640	4-alpha-glucanotransferase
DS731_RS09605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DS731_RS09615	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DS731_RS09635	COG2866	Carboxypeptidase
DS731_RS09640	COG1115	amino acid carrier protein
DS731_RS09650	COG3139	Protein of unknown function (DUF1315)
DS731_RS09670	COG0252	asparaginase activity
DS731_RS09690	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DS731_RS09695	COG0321	lipoyl(octanoyl) transferase activity
DS731_RS09700	COG2921	Belongs to the UPF0250 family
DS731_RS09705	COG1686	Belongs to the peptidase S11 family
DS731_RS09710	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DS731_RS09715	COG0772	Belongs to the SEDS family
DS731_RS09720	COG0768	penicillin binding
DS731_RS09725	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DS731_RS09730	COG0799	negative regulation of ribosome biogenesis
DS731_RS09740	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
DS731_RS09745	COG0495	leucyl-tRNA aminoacylation
DS731_RS09755	COG1067	ATP-dependent peptidase activity
DS731_RS09770	COG1534	Rna-binding protein
DS731_RS09775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DS731_RS09780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DS731_RS09785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DS731_RS09790	COG0149	triose-phosphate isomerase activity
DS731_RS09795	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DS731_RS09855	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DS731_RS09890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DS731_RS09890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DS731_RS09900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DS731_RS09995	COG0756	dUTP diphosphatase activity
DS731_RS10105	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DS731_RS10190	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DS731_RS10235	COG1597	lipid kinase activity
DS731_RS10255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS731_RS10260	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DS731_RS10265	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DS731_RS10280	COG1185	polyribonucleotide nucleotidyltransferase activity
DS731_RS10310	COG1196	nuclear chromosome segregation
DS731_RS10320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DS731_RS10330	COG0658	competence protein
DS731_RS10330	COG2333	competence protein COMEC
DS731_RS10335	COG1132	(ABC) transporter
DS731_RS10340	COG1663	tetraacyldisaccharide 4'-kinase activity
DS731_RS10380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DS731_RS10385	COG0435	Glutathione S-transferase
DS731_RS10420	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DS731_RS10425	COG1053	succinate dehydrogenase
DS731_RS10430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DS731_RS10435	COG0567	Dehydrogenase, E1 component
DS731_RS10440	COG0508	dehydrogenase complex catalyzes the overall conversion of
DS731_RS10455	COG0840	transmembrane signaling receptor activity
DS731_RS10480	COG0366	Alpha amylase catalytic
DS731_RS10500	COG0366	Alpha amylase catalytic
DS731_RS10530	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS10535	COG2267	carboxylic ester hydrolase activity
DS731_RS10555	COG0616	signal peptide processing
DS731_RS10570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DS731_RS10575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DS731_RS10580	COG0386	Belongs to the glutathione peroxidase family
DS731_RS10585	COG2084	Dehydrogenase
DS731_RS10600	COG1960	acyl-CoA dehydrogenase activity
DS731_RS10605	COG1024	Enoyl-CoA hydratase
DS731_RS10615	COG2226	methyltransferase
DS731_RS10620	COG3083	sulfuric ester hydrolase activity
DS731_RS10625	COG3082	Protein of unknown function (DUF1414)
DS731_RS10630	COG3081	Nucleoid-associated protein
DS731_RS10660	COG3275	phosphorelay sensor kinase activity
DS731_RS10665	COG3279	Response regulator of the LytR AlgR family
DS731_RS10670	COG0205	6-phosphofructokinase activity
DS731_RS10680	COG0697	spore germination
DS731_RS10685	COG2205	protein histidine kinase activity
DS731_RS10685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_RS10695	COG1054	Belongs to the UPF0176 family
DS731_RS10705	COG0513	Belongs to the DEAD box helicase family
DS731_RS10710	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DS731_RS10715	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DS731_RS10720	COG0583	DNA-binding transcription factor activity
DS731_RS10745	COG1760	l-serine dehydratase
DS731_RS10765	COG1322	Protein conserved in bacteria
DS731_RS10775	COG3547	Transposase (IS116 IS110 IS902 family)
DS731_RS10870	COG1404	Belongs to the peptidase S8 family
DS731_RS10880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DS731_RS10885	COG0022	dehydrogenase e1 component
DS731_RS10895	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DS731_RS10900	COG0515	serine threonine protein kinase
DS731_RS10905	COG1946	Acyl-CoA thioesterase
DS731_RS10910	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DS731_RS10925	COG2715	membrane protein required for spore maturation
DS731_RS10935	COG1956	GAF domain-containing protein
DS731_RS10950	COG0793	Belongs to the peptidase S41A family
DS731_RS10955	COG0733	neurotransmitter:sodium symporter activity
DS731_RS10960	COG1757	Na H antiporter
DS731_RS10965	COG0308	aminopeptidase N
DS731_RS11000	COG0167	dihydroorotate dehydrogenase activity
DS731_RS11015	COG0488	(ABC) transporter
DS731_RS11025	COG3130	regulation of translation
DS731_RS11030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DS731_RS11040	COG0415	Belongs to the DNA photolyase family
DS731_RS11045	COG0415	Belongs to the DNA photolyase family
DS731_RS11050	COG0415	Belongs to the DNA photolyase family
DS731_RS11055	COG3046	protein related to deoxyribodipyrimidine photolyase
DS731_RS11115	COG4946	Tricorn protease homolog
DS731_RS11115	COG1506	peptidase
DS731_RS11115	COG0823	Involved in the tonB-independent uptake of proteins
DS731_RS11140	COG0589	response to stress
DS731_RS11145	COG0069	glutamate synthase activity
DS731_RS11150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DS731_RS11150	COG0475	glutathione-regulated potassium exporter activity
DS731_RS11160	COG2193	ferroxidase activity
DS731_RS11170	COG3278	Belongs to the heme-copper respiratory oxidase family
DS731_RS11185	COG2010	Cytochrome c
DS731_RS11195	COG2217	Heavy metal translocating P-type atpase
DS731_RS11210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DS731_RS11215	COG0589	response to stress
DS731_RS11220	COG0037	tRNA processing
DS731_RS11225	COG1752	Esterase of the alpha-beta hydrolase superfamily
DS731_RS11245	COG1280	lysine exporter protein (LysE YggA)
DS731_RS11255	COG2897	thiosulfate sulfurtransferase activity
DS731_RS11280	COG0322	excinuclease ABC activity
DS731_RS11285	COG2197	response regulator
DS731_RS11290	COG1741	Belongs to the pirin family
DS731_RS11295	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DS731_RS11315	COG0670	Belongs to the BI1 family
DS731_RS11335	COG2920	part of a sulfur-relay system
DS731_RS11350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DS731_RS11355	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DS731_RS11360	COG0531	amino acid
DS731_RS11360	COG1674	ftsk spoiiie
DS731_RS11370	COG0686	Belongs to the AlaDH PNT family
DS731_RS11375	COG0284	orotidine-5'-phosphate decarboxylase activity
DS731_RS11380	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DS731_RS11385	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
DS731_RS11395	COG0776	regulation of translation
DS731_RS11400	COG0539	negative regulation of cytoplasmic translation
DS731_RS11405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DS731_RS11410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DS731_RS11430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DS731_RS11440	COG0633	Ferredoxin
DS731_RS11450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DS731_RS11455	COG2165	general secretion pathway protein
DS731_RS11470	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DS731_RS11475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DS731_RS11485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DS731_RS11495	COG4783	chaperone-mediated protein folding
DS731_RS11500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DS731_RS11505	COG1393	Belongs to the ArsC family
DS731_RS11520	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DS731_RS11535	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DS731_RS11545	COG1960	acyl-CoA dehydrogenase activity
DS731_RS11575	COG1215	transferase activity, transferring glycosyl groups
DS731_RS11580	COG0366	Alpha amylase catalytic
DS731_RS11585	COG0303	'Molybdopterin
DS731_RS11590	COG0534	Mate efflux family protein
DS731_RS11605	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DS731_RS11610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DS731_RS11620	COG0405	Gamma-glutamyltransferase
DS731_RS11625	COG1024	Enoyl-CoA hydratase
DS731_RS11660	COG2873	o-acetylhomoserine
DS731_RS11720	COG0596	Alpha beta hydrolase
DS731_RS11730	COG0716	FMN binding
DS731_RS11740	COG0735	belongs to the Fur family
DS731_RS11750	COG1984	allophanate hydrolase subunit 2
DS731_RS11755	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DS731_RS11765	COG2996	Protein conserved in bacteria
DS731_RS11770	COG1765	OsmC-like protein
DS731_RS11780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_RS11800	COG0436	Aminotransferase
DS731_RS11810	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DS731_RS11820	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DS731_RS11825	COG0251	oxidation-reduction process
DS731_RS11830	COG2010	Cytochrome c
DS731_RS11850	COG3384	dioxygenase
DS731_RS11860	COG0084	hydrolase, TatD family'
DS731_RS11865	COG0470	DNA polymerase III
DS731_RS11875	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DS731_RS11880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DS731_RS11885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DS731_RS11890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DS731_RS11905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DS731_RS11910	COG0416	fatty acid biosynthetic process
DS731_RS11920	COG1399	metal-binding, possibly nucleic acid-binding protein
DS731_RS11930	COG0546	phosphoglycolate phosphatase activity
DS731_RS11935	COG0564	pseudouridine synthase activity
DS731_RS11945	COG1530	ribonuclease E activity
DS731_RS11955	COG3122	Protein conserved in bacteria
DS731_RS11960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DS731_RS11965	COG3724	N-succinylarginine dihydrolase activity
DS731_RS11970	COG4932	domain protein
DS731_RS11970	COG1388	LysM domain
DS731_RS11970	COG2373	Large extracellular alpha-helical protein
DS731_RS11975	COG1301	dicarboxylic acid transport
DS731_RS11980	COG4591	ABC-type transport system involved in lipoprotein release permease component
DS731_RS11985	COG1136	(ABC) transporter
DS731_RS12025	COG0328	RNA-DNA hybrid ribonuclease activity
DS731_RS12030	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS12040	COG1566	PFAM secretion protein HlyD family protein
DS731_RS12080	COG1643	Atp-dependent helicase
DS731_RS12085	COG2963	transposase activity
DS731_RS12090	COG2801	Transposase and inactivated derivatives
DS731_RS12125	COG2925	Exonuclease
DS731_RS12135	COG3706	GGDEF domain
DS731_RS12155	COG0789	Transcriptional regulator
DS731_RS12160	COG1960	acyl-CoA dehydrogenase activity
DS731_RS12165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DS731_RS12170	COG1024	Enoyl-CoA hydratase
DS731_RS12175	COG4770	biotin carboxylase activity
DS731_RS12215	COG1639	'signal transduction protein
DS731_RS12230	COG2166	iron-sulfur cluster assembly
DS731_RS12255	COG4251	negative regulation of phosphorylation
DS731_RS12265	COG0708	Exodeoxyribonuclease III
DS731_RS12280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DS731_RS12285	COG4591	ABC-type transport system involved in lipoprotein release permease component
DS731_RS12295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DS731_RS12305	COG0471	metal ion transport
DS731_RS12310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DS731_RS12325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DS731_RS12325	COG0072	phenylalanine-tRNA ligase activity
DS731_RS12355	COG3001	Fructosamine kinase
DS731_RS12390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DS731_RS12395	COG0154	amidase activity
DS731_RS12405	COG0730	response to heat
DS731_RS12410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DS731_RS12425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DS731_RS12430	COG2233	PERMEase
DS731_RS12445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DS731_RS12450	COG2252	PERMEase
DS731_RS12460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_RS12460	COG4191	Histidine kinase
DS731_RS12470	COG1309	transcriptional regulator
DS731_RS12480	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DS731_RS12495	COG2351	hydroxyisourate hydrolase activity
DS731_RS12500	COG0402	S-adenosylhomocysteine deaminase activity
DS731_RS12520	COG0667	Aldo Keto reductase
DS731_RS12535	COG1501	Belongs to the glycosyl hydrolase 31 family
DS731_RS12560	COG2755	lipolytic protein G-D-S-L family
DS731_RS12560	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DS731_RS12615	COG1484	DNA-dependent DNA replication
DS731_RS12670	COG1846	Transcriptional regulator
DS731_RS12690	COG1522	sequence-specific DNA binding
DS731_RS12695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DS731_RS12700	COG4251	negative regulation of phosphorylation
DS731_RS12705	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS12710	COG2860	membrane
DS731_RS12720	COG3665	Urea carboxylase-associated protein
DS731_RS12750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DS731_RS12780	COG1473	amidohydrolase
DS731_RS12795	COG0668	transmembrane transport
DS731_RS12800	COG2814	Major facilitator Superfamily
DS731_RS12810	COG1228	amidohydrolase
DS731_RS12835	COG0582	viral genome integration into host DNA
DS731_RS12865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DS731_RS12870	COG0601	transmembrane transport
DS731_RS12880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DS731_RS12900	COG0473	3-isopropylmalate dehydrogenase activity
DS731_RS12905	COG1012	belongs to the aldehyde dehydrogenase family
DS731_RS12910	COG1881	PFAM PEBP family protein
DS731_RS12950	COG2308	Evidence 4 Homologs of previously reported genes of
DS731_RS12960	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DS731_RS12970	COG4771	TonB-dependent receptor
DS731_RS12985	COG4771	TonB-dependent receptor
DS731_RS12995	COG1595	DNA-templated transcription, initiation
DS731_RS13000	COG0405	Gamma-glutamyltransferase
DS731_RS13005	COG0405	Gamma-glutamyltransferase
DS731_RS13010	COG2198	Histidine kinase
DS731_RS13010	COG0643	Histidine kinase
DS731_RS13025	COG1136	(ABC) transporter
DS731_RS13030	COG3045	CreA protein
DS731_RS13040	COG1280	lysine exporter protein (LysE YggA)
DS731_RS13045	COG1393	Belongs to the ArsC family
DS731_RS13075	COG2988	succinylglutamate desuccinylase activity
DS731_RS13090	COG0583	DNA-binding transcription factor activity
DS731_RS13100	COG0058	SHG alpha-glucan phosphorylase activity
DS731_RS13105	COG0033	Phosphoglucomutase
DS731_RS13110	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
DS731_RS13115	COG0714	Associated with various cellular activities
DS731_RS13140	COG2363	Small membrane protein
DS731_RS13150	COG0583	DNA-binding transcription factor activity
DS731_RS13160	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DS731_RS13170	COG3437	response regulator, receiver
DS731_RS13170	COG0784	Response regulator, receiver
DS731_RS13175	COG2890	protein-(glutamine-N5) methyltransferase activity
DS731_RS13185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DS731_RS13190	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DS731_RS13195	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DS731_RS13205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DS731_RS13230	COG0012	GTP binding
DS731_RS13235	COG2031	fatty acid transporter
DS731_RS13260	COG1115	amino acid carrier protein
DS731_RS13270	COG1309	transcriptional regulator
DS731_RS13280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS731_RS13290	COG1702	phosphate starvation-inducible protein PhoH
DS731_RS13300	COG4535	Mg2 and Co2 transporter CorC
DS731_RS13305	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DS731_RS13330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DS731_RS13335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DS731_RS13340	COG0505	Belongs to the CarA family
DS731_RS13345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DS731_RS13365	COG3909	cytochrome
DS731_RS13370	COG1280	lysine exporter protein (LysE YggA)
DS731_RS13415	COG0471	metal ion transport
DS731_RS13430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DS731_RS13430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DS731_RS13440	COG2226	methyltransferase
DS731_RS13445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DS731_RS13450	COG1388	LysM domain
DS731_RS13450	COG0741	lytic transglycosylase activity
DS731_RS13460	COG0215	cysteine-tRNA ligase activity
DS731_RS13465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DS731_RS13470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DS731_RS13480	COG1404	Belongs to the peptidase S8 family
DS731_RS13500	COG1785	Belongs to the alkaline phosphatase family
DS731_RS13505	COG1785	Belongs to the alkaline phosphatase family
DS731_RS13515	COG1585	Membrane protein implicated in regulation of membrane protease activity
DS731_RS13520	COG2268	Band 7 protein
DS731_RS13525	COG4585	Histidine kinase
DS731_RS13565	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DS731_RS13570	COG1286	toxin biosynthetic process
DS731_RS13575	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
DS731_RS13580	COG0285	dihydrofolate synthase activity
DS731_RS13590	COG0101	tRNA pseudouridine synthase activity
DS731_RS13605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DS731_RS13615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DS731_RS13615	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DS731_RS13645	COG3101	peptidyl-lysine hydroxylation
DS731_RS13665	COG0446	pyridine nucleotide-disulphide oxidoreductase
DS731_RS13665	COG1902	pentaerythritol trinitrate reductase activity
DS731_RS13685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS731_RS13690	COG1309	transcriptional regulator
DS731_RS13695	COG4399	Belongs to the UPF0754 family
DS731_RS13730	COG2186	Transcriptional regulator
DS731_RS13740	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DS731_RS13745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DS731_RS13750	COG2983	Belongs to the UPF0260 family
DS731_RS13755	COG0179	Fumarylacetoacetate (FAA) hydrolase
DS731_RS13770	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DS731_RS13775	COG0318	PFAM AMP-dependent synthetase and ligase
DS731_RS13780	COG2267	carboxylic ester hydrolase activity
DS731_RS13795	COG1214	PFAM Peptidase M22, glycoprotease
DS731_RS13800	COG1199	ATP-dependent helicase activity
DS731_RS13820	COG0840	transmembrane signaling receptor activity
DS731_RS13835	COG0640	Transcriptional regulator
DS731_RS13845	COG0798	PFAM Bile acid sodium symporter
DS731_RS13860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DS731_RS13865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DS731_RS13870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DS731_RS13875	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DS731_RS13875	COG0131	Imidazoleglycerol-phosphate dehydratase
DS731_RS13880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DS731_RS13905	COG0681	Belongs to the peptidase S26 family
DS731_RS13910	COG0071	Belongs to the small heat shock protein (HSP20) family
DS731_RS13925	COG0702	epimerase
DS731_RS13945	COG0326	Molecular chaperone. Has ATPase activity
DS731_RS13950	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DS731_RS13970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DS731_RS13975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DS731_RS13985	COG3220	belongs to the UPF0276 family
DS731_RS14030	COG1183	phosphatidylcholine synthase activity
DS731_RS14050	COG0542	response to heat
DS731_RS14055	COG1496	oxidoreductase activity
DS731_RS14060	COG0564	pseudouridine synthase activity
DS731_RS14065	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DS731_RS14070	COG3806	Anti-sigma factor
DS731_RS14075	COG1595	DNA-templated transcription, initiation
DS731_RS14090	COG4221	oxidoreductase activity
DS731_RS14105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DS731_RS14115	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DS731_RS14125	COG0142	geranyltranstransferase activity
DS731_RS14135	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DS731_RS14140	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DS731_RS14150	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DS731_RS14165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DS731_RS14165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DS731_RS14180	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DS731_RS14185	COG0488	(ABC) transporter
DS731_RS14195	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DS731_RS14205	COG0560	Phosphoserine phosphatase
DS731_RS14215	COG0084	hydrolase, TatD family'
DS731_RS14225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DS731_RS14230	COG0571	ribonuclease III activity
DS731_RS14235	COG0681	Belongs to the peptidase S26 family
DS731_RS14260	COG1595	DNA-templated transcription, initiation
DS731_RS14265	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DS731_RS14280	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DS731_RS14290	COG1047	Peptidyl-prolyl cis-trans
DS731_RS14355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DS731_RS14360	COG1047	Peptidyl-prolyl cis-trans
DS731_RS14370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DS731_RS14375	COG0196	riboflavin kinase activity
DS731_RS14380	COG0728	peptidoglycan biosynthetic process
DS731_RS14385	COG0268	Binds directly to 16S ribosomal RNA
DS731_RS14415	COG3682	Transcriptional regulator
DS731_RS14420	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DS731_RS14430	COG1566	PFAM secretion protein HlyD family protein
DS731_RS14450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DS731_RS14455	COG0776	regulation of translation
DS731_RS14460	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DS731_RS14465	COG2165	general secretion pathway protein
DS731_RS14470	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DS731_RS14475	COG0740	serine-type endopeptidase activity
DS731_RS14480	COG0544	peptidyl-prolyl cis-trans isomerase activity
DS731_RS14530	COG1131	(ABC) transporter
DS731_RS14535	COG1720	tRNA m6t6A37 methyltransferase activity
DS731_RS14550	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
DS731_RS14555	COG0123	including yeast histone deacetylase and acetoin utilization protein
DS731_RS14560	COG0840	transmembrane signaling receptor activity
DS731_RS14565	COG0604	alcohol dehydrogenase
DS731_RS14570	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DS731_RS14575	COG1064	alcohol dehydrogenase
DS731_RS14590	COG0516	GMP reductase activity
DS731_RS14590	COG0517	IMP dehydrogenase activity
DS731_RS14595	COG1570	exodeoxyribonuclease VII activity
DS731_RS14610	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DS731_RS14615	COG2976	Protein conserved in bacteria
DS731_RS14640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DS731_RS14650	COG0339	signal peptide processing
DS731_RS14660	COG2166	iron-sulfur cluster assembly
DS731_RS14665	COG2151	metal-sulfur cluster biosynthetic enzyme
DS731_RS14675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DS731_RS14680	COG0719	Fe-S assembly protein
DS731_RS14685	COG0396	ATPase activity
DS731_RS14690	COG0719	Fe-S assembly protein
DS731_RS14695	COG1104	cysteine desulfurase activity
DS731_RS14700	COG1959	2 iron, 2 sulfur cluster binding
DS731_RS14710	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DS731_RS14715	COG0483	inositol monophosphate 1-phosphatase activity
DS731_RS14720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DS731_RS14725	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DS731_RS14730	COG1862	Preprotein translocase
DS731_RS14735	COG0343	queuine tRNA-ribosyltransferase activity
DS731_RS14755	COG1842	Phage shock protein A
DS731_RS14760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DS731_RS14780	COG0754	glutathionylspermidine amidase activity
DS731_RS14795	COG1785	Belongs to the alkaline phosphatase family
DS731_RS14800	COG0835	chemotaxis
DS731_RS14800	COG0784	Response regulator, receiver
DS731_RS14850	COG1045	serine acetyltransferase
DS731_RS14855	COG1215	transferase activity, transferring glycosyl groups
DS731_RS14865	COG0726	polysaccharide deacetylase
DS731_RS14870	COG0438	transferase activity, transferring glycosyl groups
DS731_RS14875	COG0438	transferase activity, transferring glycosyl groups
DS731_RS14890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DS731_RS14905	COG0489	protein tyrosine kinase activity
DS731_RS14915	COG3409	Peptidoglycan-binding domain 1 protein
DS731_RS14915	COG3267	Type II secretory pathway component ExeA
DS731_RS14920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DS731_RS14920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DS731_RS14925	COG2827	Endonuclease containing a URI domain
DS731_RS14945	COG1560	Kdo2-lipid A biosynthetic process
DS731_RS14980	COG5001	Diguanylate cyclase
DS731_RS14980	COG3300	MHYT domain
DS731_RS14985	COG1435	thymidine kinase activity
DS731_RS14990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DS731_RS15000	COG1609	Transcriptional regulator
DS731_RS15010	COG0583	DNA-binding transcription factor activity
DS731_RS15015	COG1595	DNA-templated transcription, initiation
DS731_RS15025	COG1473	amidohydrolase
DS731_RS15030	COG1473	amidohydrolase
DS731_RS15040	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DS731_RS15075	COG2894	cell division
DS731_RS15080	COG0850	regulation of cytokinetic process
DS731_RS15110	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DS731_RS15120	COG0535	radical SAM domain protein
DS731_RS15150	COG1971	Probably functions as a manganese efflux pump
DS731_RS15170	COG4269	membrane
DS731_RS15195	COG0604	alcohol dehydrogenase
DS731_RS15200	COG1309	transcriptional regulator
DS731_RS15220	COG0668	transmembrane transport
DS731_RS15225	COG0668	transmembrane transport
DS731_RS15230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_RS15230	COG4191	Histidine kinase
DS731_RS15235	COG0628	permease
DS731_RS15240	COG0513	Belongs to the DEAD box helicase family
DS731_RS15250	COG0210	DNA helicase
DS731_RS15255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DS731_RS15300	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DS731_RS15300	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DS731_RS15315	COG0583	DNA-binding transcription factor activity
DS731_RS15330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS731_RS15335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS731_RS15340	COG0006	proline dipeptidase activity
DS731_RS15345	COG3079	Belongs to the UPF0149 family
DS731_RS15370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DS731_RS15375	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DS731_RS15380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DS731_RS15395	COG2963	transposase activity
DS731_RS15400	COG2801	Transposase and inactivated derivatives
DS731_RS15420	COG3313	Fe-S protein
DS731_RS15440	COG0583	DNA-binding transcription factor activity
DS731_RS15445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DS731_RS15450	COG0508	dehydrogenase complex catalyzes the overall conversion of
DS731_RS15455	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DS731_RS15470	COG3023	N-Acetylmuramoyl-L-alanine amidase
DS731_RS15475	COG3577	Aspartyl protease
DS731_RS15485	COG4969	Belongs to the N-Me-Phe pilin family
DS731_RS15490	COG1459	type II secretion system
DS731_RS15500	COG0237	dephospho-CoA kinase activity
DS731_RS15505	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DS731_RS15510	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DS731_RS15515	COG2988	succinylglutamate desuccinylase activity
DS731_RS15520	COG0840	transmembrane signaling receptor activity
DS731_RS15525	COG0745	RESPONSE REGULATOR receiver
DS731_RS15540	COG0643	Histidine kinase
DS731_RS15540	COG2198	Histidine kinase
DS731_RS15545	COG0745	RESPONSE REGULATOR receiver
DS731_RS15550	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DS731_RS15560	COG2201	protein-glutamate methylesterase activity
DS731_RS15565	COG0835	chemotaxis
DS731_RS15570	COG3290	protein histidine kinase activity
DS731_RS15570	COG0840	transmembrane signaling receptor activity
DS731_RS15575	COG0494	nUDIX hydrolase
DS731_RS15585	COG1196	nuclear chromosome segregation
DS731_RS15585	COG0741	lytic transglycosylase activity
DS731_RS15585	COG0739	heme binding
DS731_RS15595	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DS731_RS15605	COG0849	cell division
DS731_RS15610	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DS731_RS15615	COG1181	Belongs to the D-alanine--D-alanine ligase family
DS731_RS15620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DS731_RS15630	COG0772	Belongs to the SEDS family
DS731_RS15635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DS731_RS15645	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DS731_RS15650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DS731_RS15655	COG0768	penicillin binding
DS731_RS15660	COG3116	cell division
DS731_RS15670	COG2001	Belongs to the MraZ family
DS731_RS15675	COG4677	pectinesterase activity
DS731_RS15690	COG1119	ATPase activity
DS731_RS15715	COG3263	regulation of cellular component size
DS731_RS15720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DS731_RS15730	COG4319	ketosteroid isomerase
DS731_RS15755	COG2204	response regulator
DS731_RS15760	COG2198	Histidine kinase
DS731_RS15760	COG0784	Response regulator, receiver
DS731_RS15760	COG5002	protein histidine kinase activity
DS731_RS15780	COG0668	transmembrane transport
DS731_RS15790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DS731_RS15800	COG0189	ligase activity
DS731_RS15805	COG1678	Uncharacterized ACR, COG1678
DS731_RS15810	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DS731_RS15835	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DS731_RS15840	COG0762	integral membrane protein
DS731_RS15855	COG2130	NADP-dependent
DS731_RS15875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DS731_RS15900	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DS731_RS15910	COG0083	homoserine kinase activity
DS731_RS15920	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DS731_RS15955	COG4221	oxidoreductase activity
DS731_RS15960	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DS731_RS15970	COG2205	protein histidine kinase activity
DS731_RS16010	COG1748	Saccharopine dehydrogenase
DS731_RS16025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DS731_RS16030	COG3107	peptidoglycan biosynthetic process
DS731_RS16035	COG0792	nuclease activity
DS731_RS16075	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DS731_RS16080	COG0372	Belongs to the citrate synthase family
DS731_RS16085	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DS731_RS16115	COG2198	Histidine kinase
DS731_RS16115	COG0784	Response regulator, receiver
DS731_RS16115	COG5002	protein histidine kinase activity
DS731_RS16120	COG0067	glutamate synthase
DS731_RS16120	COG0069	glutamate synthase activity
DS731_RS16120	COG0070	glutamate synthase
DS731_RS16125	COG0493	'glutamate synthase
DS731_RS16135	COG3693	PFAM glycoside hydrolase, family 10
DS731_RS16150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DS731_RS16155	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DS731_RS16160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DS731_RS16175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DS731_RS16180	COG0739	heme binding
DS731_RS16180	COG0741	lytic transglycosylase activity
DS731_RS16180	COG1196	nuclear chromosome segregation
DS731_RS16190	COG0625	glutathione transferase activity
DS731_RS16200	COG2223	nitrite transmembrane transporter activity
DS731_RS16205	COG2815	serine threonine protein kinase
DS731_RS16205	COG0515	serine threonine protein kinase
DS731_RS16220	COG1981	membrane
DS731_RS16235	COG1914	H( )-stimulated, divalent metal cation uptake system
DS731_RS16240	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DS731_RS16250	COG1217	gtp-binding protein TYPA
DS731_RS16255	COG0174	glutamine synthetase
DS731_RS16265	COG3852	Histidine kinase
DS731_RS16270	COG2204	response regulator
DS731_RS16275	COG3437	response regulator, receiver
DS731_RS16305	COG3437	response regulator, receiver
DS731_RS16305	COG3850	Histidine kinase
DS731_RS16305	COG4999	Histidine kinase
DS731_RS16305	COG2205	protein histidine kinase activity
DS731_RS16310	COG0525	valine-tRNA ligase activity
DS731_RS16315	COG2927	DNA polymerase III (CHI subunit)
DS731_RS16320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DS731_RS16325	COG0795	lipopolysaccharide-transporting ATPase activity
DS731_RS16330	COG0795	lipopolysaccharide-transporting ATPase activity
DS731_RS16390	COG2801	Transposase and inactivated derivatives
DS731_RS16420	COG1971	Probably functions as a manganese efflux pump
DS731_RS16475	COG2936	dipeptidyl-peptidase activity
DS731_RS16500	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DS731_RS16530	COG3250	beta-galactosidase activity
DS731_RS16565	COG1472	Belongs to the glycosyl hydrolase 3 family
DS731_RS16570	COG4948	Mandelate Racemase Muconate Lactonizing
DS731_RS16575	COG3661	Belongs to the glycosyl hydrolase 67 family
DS731_RS16580	COG0477	Major facilitator Superfamily
DS731_RS16590	COG0784	Response regulator, receiver
DS731_RS16590	COG2205	protein histidine kinase activity
DS731_RS16595	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DS731_RS16600	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DS731_RS16605	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DS731_RS16610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DS731_RS16655	COG1538	Outer membrane efflux protein
DS731_RS16665	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS16685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DS731_RS16705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DS731_RS16795	COG1609	Transcriptional regulator
DS731_RS16820	COG0702	epimerase
DS731_RS16825	COG2267	carboxylic ester hydrolase activity
DS731_RS16850	COG1609	Transcriptional regulator
DS731_RS16860	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DS731_RS16860	COG3264	Mechanosensitive ion channel
DS731_RS16870	COG1024	Enoyl-CoA hydratase
DS731_RS16875	COG1012	belongs to the aldehyde dehydrogenase family
DS731_RS16880	COG2271	Major facilitator Superfamily
DS731_RS16965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DS731_RS16970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DS731_RS16975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DS731_RS17005	COG4206	TonB-dependent receptor
DS731_RS17030	COG0583	DNA-binding transcription factor activity
DS731_RS17035	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DS731_RS17035	COG1082	Xylose isomerase domain protein TIM barrel
DS731_RS17045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DS731_RS17050	COG3659	wide pore channel activity
DS731_RS17060	COG0738	Major facilitator superfamily
DS731_RS17120	COG0842	Transport permease protein
DS731_RS17125	COG0842	Transport permease protein
DS731_RS17130	COG1131	(ABC) transporter
DS731_RS17145	COG0277	FAD linked oxidase domain protein
DS731_RS17150	COG0513	Belongs to the DEAD box helicase family
DS731_RS17155	COG1278	Cold shock
DS731_RS17165	COG5001	Diguanylate cyclase
DS731_RS17165	COG3300	MHYT domain
DS731_RS17180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DS731_RS17205	COG1757	Na H antiporter
DS731_RS17215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DS731_RS17225	COG1845	cytochrome c oxidase, subunit III
DS731_RS17235	COG0109	protoheme IX farnesyltransferase activity
DS731_RS17255	COG1902	pentaerythritol trinitrate reductase activity
DS731_RS17260	COG2755	lipolytic protein G-D-S-L family
DS731_RS17260	COG0657	acetylesterase activity
DS731_RS17265	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DS731_RS17280	COG3568	Endonuclease Exonuclease Phosphatase
DS731_RS17285	COG0583	DNA-binding transcription factor activity
DS731_RS17300	COG0730	response to heat
DS731_RS17305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DS731_RS17310	COG0840	transmembrane signaling receptor activity
DS731_RS17315	COG0745	RESPONSE REGULATOR receiver
DS731_RS17320	COG0643	Histidine kinase
DS731_RS17320	COG2198	Histidine kinase
DS731_RS17325	COG0835	chemotaxis
DS731_RS17340	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DS731_RS17360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_RS17360	COG4191	Histidine kinase
DS731_RS17370	COG0417	DNA replication proofreading
DS731_RS17430	COG3300	MHYT domain
DS731_RS17430	COG5001	Diguanylate cyclase
DS731_RS17435	COG4191	Histidine kinase
DS731_RS17440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DS731_RS17450	COG3300	MHYT domain
DS731_RS17450	COG5001	Diguanylate cyclase
DS731_RS17470	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DS731_RS17490	COG1983	PspC domain protein
DS731_RS17495	COG1842	Phage shock protein A
DS731_RS17505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DS731_RS17515	COG2205	protein histidine kinase activity
DS731_RS17520	COG0745	RESPONSE REGULATOR receiver
DS731_RS17530	COG2409	Drug exporters of the RND superfamily
DS731_RS17545	COG4946	Tricorn protease homolog
DS731_RS17545	COG1506	peptidase
DS731_RS17545	COG0823	Involved in the tonB-independent uptake of proteins
DS731_RS17565	COG1472	Belongs to the glycosyl hydrolase 3 family
DS731_RS17575	COG3547	Transposase (IS116 IS110 IS902 family)
DS731_RS17580	COG1874	Beta-galactosidase
DS731_RS17605	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DS731_RS17620	COG0204	Acyl-transferase
DS731_RS17625	COG0204	Acyl-transferase
DS731_RS17630	COG0668	transmembrane transport
DS731_RS17645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DS731_RS17650	COG0733	neurotransmitter:sodium symporter activity
DS731_RS17665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DS731_RS17670	COG0783	Belongs to the Dps family
DS731_RS17695	COG0848	biopolymer transport protein
DS731_RS17710	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DS731_RS17730	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DS731_RS17735	COG0702	epimerase
DS731_RS17750	COG5001	Diguanylate cyclase
DS731_RS17750	COG5002	protein histidine kinase activity
DS731_RS17765	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DS731_RS17775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DS731_RS17795	COG1477	protein flavinylation
DS731_RS17800	COG2871	sodium ion transport
DS731_RS17805	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DS731_RS17810	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DS731_RS17815	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DS731_RS17820	COG1805	sodium ion transport
DS731_RS17825	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DS731_RS17830	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DS731_RS17835	COG0545	Peptidyl-prolyl cis-trans isomerase
DS731_RS17840	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DS731_RS17845	COG2801	Transposase and inactivated derivatives
DS731_RS17850	COG2963	transposase activity
DS731_RS17880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DS731_RS17885	COG0039	L-malate dehydrogenase activity
DS731_RS17890	COG1438	arginine binding
DS731_RS17895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_RS17900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS731_RS17930	COG0572	uridine kinase
DS731_RS17935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DS731_RS17950	COG1192	Involved in chromosome partitioning
DS731_RS17955	COG2999	glutathione oxidoreductase activity
DS731_RS17960	COG3706	GGDEF domain
DS731_RS17970	COG5001	Diguanylate cyclase
DS731_RS17970	COG3706	GGDEF domain
DS731_RS17970	COG4251	negative regulation of phosphorylation
DS731_RS17970	COG2203	Gaf domain
DS731_RS17985	COG0517	IMP dehydrogenase activity
DS731_RS17985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DS731_RS17990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS731_RS18000	COG2198	Histidine kinase
DS731_RS18000	COG2205	protein histidine kinase activity
DS731_RS18000	COG0784	Response regulator, receiver
DS731_RS18010	COG0189	ligase activity
DS731_RS18020	COG0189	ligase activity
DS731_RS18020	COG4067	protein conserved in archaea
DS731_RS18030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DS731_RS18040	COG1283	sodium-dependent phosphate transmembrane transporter activity
DS731_RS18045	COG0667	Aldo Keto reductase
DS731_RS18060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DS731_RS18065	COG0049	tRNA binding
DS731_RS18070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DS731_RS18075	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DS731_RS18080	COG0085	RNA polymerase activity
DS731_RS18085	COG0222	ribosome binding
DS731_RS18090	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DS731_RS18095	COG0081	regulation of translation
DS731_RS18100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DS731_RS18105	COG0250	Participates in transcription elongation, termination and antitermination
DS731_RS18110	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DS731_RS18120	COG1132	(ABC) transporter
DS731_RS18125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DS731_RS18130	COG0513	Belongs to the DEAD box helicase family
DS731_RS18140	COG0418	dihydroorotase activity
DS731_RS18150	COG3040	lipid binding
DS731_RS18155	COG4989	oxidoreductase activity
DS731_RS18160	COG0346	lactoylglutathione lyase activity
DS731_RS18165	COG1940	carbohydrate kinase activity
DS731_RS18185	COG0302	gtp cyclohydrolase
DS731_RS18190	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS18195	COG2957	Belongs to the agmatine deiminase family
DS731_RS18200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DS731_RS18215	COG1201	RNA secondary structure unwinding
DS731_RS18225	COG1793	dna ligase
DS731_RS18230	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
DS731_RS18250	COG2234	aminopeptidase activity
DS731_RS18265	COG1522	sequence-specific DNA binding
DS731_RS18275	COG0436	Aminotransferase
DS731_RS18305	COG2971	BadF BadG BcrA BcrD
DS731_RS18310	COG1609	Transcriptional regulator
DS731_RS18325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS731_RS18330	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DS731_RS18335	COG3876	Protein conserved in bacteria
DS731_RS18340	COG1737	Transcriptional regulator
DS731_RS18405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DS731_RS18410	COG1757	Na H antiporter
DS731_RS18425	COG1012	belongs to the aldehyde dehydrogenase family
DS731_RS18435	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
DS731_RS18445	COG3118	belongs to the thioredoxin family
DS731_RS18450	COG1982	Orn Lys Arg decarboxylase major
DS731_RS18455	COG2133	pyrroloquinoline quinone binding
DS731_RS18460	COG0783	Belongs to the Dps family
DS731_RS18475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DS731_RS18480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DS731_RS18490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DS731_RS18495	COG0784	Response regulator, receiver
DS731_RS18495	COG2205	protein histidine kinase activity
DS731_RS18500	COG1473	amidohydrolase
DS731_RS18505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DS731_RS18510	COG3118	belongs to the thioredoxin family
DS731_RS18515	COG0513	Belongs to the DEAD box helicase family
DS731_RS18520	COG0248	Ppx GppA phosphatase
DS731_RS18535	COG0084	hydrolase, TatD family'
DS731_RS18545	COG0805	protein transport
DS731_RS18550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DS731_RS18570	COG0028	Belongs to the TPP enzyme family
DS731_RS18575	COG3085	chromosome segregation
DS731_RS18585	COG0457	Tetratricopeptide repeat
DS731_RS18595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DS731_RS18610	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DS731_RS18615	COG1162	GTPase activity
DS731_RS18630	COG0584	glycerophosphoryl diester phosphodiesterase
DS731_RS18640	COG2861	carbohydrate metabolic process
DS731_RS18645	COG4942	peptidase
DS731_RS18655	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DS731_RS18665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DS731_RS18675	COG1136	(ABC) transporter
DS731_RS18675	COG0577	efflux transmembrane transporter activity
DS731_RS18680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS731_RS18685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DS731_RS18690	COG2267	carboxylic ester hydrolase activity
DS731_RS18695	COG2205	protein histidine kinase activity
DS731_RS18700	COG0745	RESPONSE REGULATOR receiver
DS731_RS18705	COG1803	Methylglyoxal synthase
DS731_RS18720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DS731_RS18725	COG0137	argininosuccinate synthase activity
DS731_RS18735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DS731_RS18735	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DS731_RS18750	COG2808	Putative FMN-binding domain
DS731_RS18770	COG0281	malic enzyme
DS731_RS18775	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DS731_RS18810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DS731_RS18820	COG1671	Belongs to the UPF0178 family
DS731_RS18825	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DS731_RS18845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DS731_RS18850	COG0180	Tryptophanyl-tRNA synthetase
DS731_RS18865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DS731_RS18870	COG3138	arginine N-succinyltransferase
DS731_RS18875	COG1012	belongs to the aldehyde dehydrogenase family
DS731_RS18905	COG2755	lipolytic protein G-D-S-L family
DS731_RS18925	COG3254	rhamnose metabolic process
DS731_RS18950	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DS731_RS18960	COG0823	Involved in the tonB-independent uptake of proteins
DS731_RS18965	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS18975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DS731_RS19005	COG2056	Na+-H+ antiporter family
DS731_RS19010	COG1228	amidohydrolase
DS731_RS19015	COG2986	histidine ammonia-lyase
DS731_RS19025	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DS731_RS19030	COG5002	protein histidine kinase activity
DS731_RS19030	COG2205	protein histidine kinase activity
DS731_RS19030	COG0784	Response regulator, receiver
DS731_RS19040	COG0540	Belongs to the ATCase OTCase family
DS731_RS19055	COG2837	iron assimilation
DS731_RS19060	COG0405	Gamma-glutamyltransferase
DS731_RS19065	COG0753	catalase activity
DS731_RS19075	COG0753	catalase activity
DS731_RS19080	COG0004	ammonium transporteR
DS731_RS19085	COG0347	Belongs to the P(II) protein family
DS731_RS19095	COG2354	Protein conserved in bacteria
DS731_RS19105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DS731_RS19115	COG3243	poly(R)-hydroxyalkanoic acid synthase
DS731_RS19125	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
DS731_RS19145	COG2951	lytic endotransglycosylase activity
DS731_RS19150	COG1028	Short-chain dehydrogenase reductase Sdr
DS731_RS19155	COG1643	Atp-dependent helicase
DS731_RS19160	COG3706	GGDEF domain
DS731_RS19170	COG0788	formyltetrahydrofolate deformylase activity
DS731_RS19175	COG0339	signal peptide processing
DS731_RS19195	COG1519	Transferase
DS731_RS19200	COG0859	PFAM glycosyl transferase family 9
DS731_RS19205	COG0297	glycogen (starch) synthase activity
DS731_RS19210	COG0454	-acetyltransferase
DS731_RS19210	COG0456	acetyltransferase
DS731_RS19230	COG0579	oxidoreductase
DS731_RS19255	COG2211	Major facilitator Superfamily
DS731_RS19265	COG0673	inositol 2-dehydrogenase activity
DS731_RS19270	COG1609	Transcriptional regulator
DS731_RS19300	COG0477	Major facilitator Superfamily
DS731_RS19305	COG1609	Transcriptional regulator
DS731_RS19305	COG2207	Transcriptional regulator
DS731_RS19310	COG1070	Carbohydrate kinase
DS731_RS19315	COG2115	Belongs to the xylose isomerase family
DS731_RS19320	COG0436	Aminotransferase
DS731_RS19330	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DS731_RS19350	COG0643	Histidine kinase
DS731_RS19350	COG2198	Histidine kinase
DS731_RS19355	COG0745	RESPONSE REGULATOR receiver
DS731_RS19365	COG0793	Belongs to the peptidase S41A family
DS731_RS19365	COG4946	Tricorn protease homolog
DS731_RS19385	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DS731_RS19395	COG2267	carboxylic ester hydrolase activity
DS731_RS19400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DS731_RS19410	COG0297	glycogen (starch) synthase activity
DS731_RS19415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_RS19415	COG4191	Histidine kinase
DS731_RS19420	COG0745	RESPONSE REGULATOR receiver
DS731_RS19425	COG0312	modulator of DNA gyrase
DS731_RS19430	COG3028	Belongs to the UPF0307 family
DS731_RS19445	COG0312	modulator of DNA gyrase
DS731_RS19450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DS731_RS19465	COG0424	maF-like protein
DS731_RS19470	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DS731_RS19475	COG1792	Involved in formation and maintenance of cell shape
DS731_RS19480	COG1077	Cell shape determining protein MreB Mrl
DS731_RS19500	COG4969	Belongs to the N-Me-Phe pilin family
DS731_RS19505	COG2165	general secretion pathway protein
DS731_RS19510	COG2165	general secretion pathway protein
DS731_RS19520	COG1459	type II secretion system
DS731_RS19525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DS731_RS19535	COG3409	Peptidoglycan-binding domain 1 protein
DS731_RS19535	COG3267	Type II secretory pathway component ExeA
DS731_RS19570	COG0110	maltose O-acetyltransferase activity
DS731_RS19595	COG0629	single-stranded DNA binding
DS731_RS19605	COG3250	beta-galactosidase activity
DS731_RS19610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DS731_RS19640	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DS731_RS19645	COG1085	galactose-1-phosphate uridylyltransferase
DS731_RS19655	COG1609	Transcriptional regulator
DS731_RS19670	COG0471	metal ion transport
DS731_RS19670	COG0490	domain, Protein
DS731_RS19685	COG2814	Major facilitator Superfamily
DS731_RS19690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DS731_RS19710	COG2080	2 iron, 2 sulfur cluster binding
DS731_RS19715	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DS731_RS19720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DS731_RS19740	COG3842	ATPase activity
DS731_RS19745	COG4988	ABC transporter
DS731_RS19750	COG4890	Cyd operon protein YbgT
DS731_RS19755	COG1294	oxidase, subunit
DS731_RS19760	COG1271	oxidase subunit
DS731_RS19780	COG1566	PFAM secretion protein HlyD family protein
DS731_RS19815	COG0673	inositol 2-dehydrogenase activity
DS731_RS19835	COG4251	negative regulation of phosphorylation
DS731_RS19870	COG4206	TonB-dependent receptor
DS731_RS19895	COG1252	NADH dehydrogenase
DS731_RS19915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_RS19920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DS731_RS19925	COG1116	anion transmembrane transporter activity
DS731_RS19935	COG2205	protein histidine kinase activity
DS731_RS19935	COG0784	Response regulator, receiver
DS731_RS19935	COG2198	Histidine kinase
DS731_RS19940	COG0583	DNA-binding transcription factor activity
DS731_RS19955	COG1129	ABC transporter
DS731_RS19955	COG0842	Transport permease protein
DS731_RS19960	COG1131	(ABC) transporter
DS731_RS19990	COG0348	domain, Protein
DS731_RS19990	COG3901	Regulator of nitric oxide reductase transcription
DS731_RS20005	COG0583	DNA-binding transcription factor activity
DS731_RS20010	COG2814	Major facilitator Superfamily
DS731_RS20025	COG2205	protein histidine kinase activity
DS731_RS20035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS731_RS20045	COG1538	Outer membrane efflux protein
DS731_RS20060	COG0745	RESPONSE REGULATOR receiver
DS731_RS20090	COG0463	Glycosyl transferase, family 2
DS731_RS20100	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DS731_RS20105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DS731_RS20115	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DS731_RS20120	COG3038	cytochrome b561
DS731_RS20135	COG0583	DNA-binding transcription factor activity
DS731_RS20140	COG1752	Esterase of the alpha-beta hydrolase superfamily
DS731_RS20145	COG2326	polyphosphate kinase activity
DS731_RS20175	COG0562	UDP-galactopyranose mutase
DS731_RS20180	COG0583	DNA-binding transcription factor activity
DS731_RS20220	COG2165	general secretion pathway protein
DS731_RS20285	COG0805	protein transport
DS731_RS20295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DS731_RS20320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DS731_RS20330	COG0673	inositol 2-dehydrogenase activity
DS731_RS20340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DS731_RS20345	COG3706	GGDEF domain
DS731_RS20365	COG2186	Transcriptional regulator
DS731_RS20385	COG4585	Histidine kinase
DS731_RS20390	COG2197	response regulator
DS731_RS20395	COG3940	Belongs to the glycosyl hydrolase 43 family
DS731_RS20400	COG3507	Belongs to the glycosyl hydrolase 43 family
DS731_RS20415	COG3940	Belongs to the glycosyl hydrolase 43 family
DS731_RS20420	COG2211	Major facilitator Superfamily
DS731_RS20435	COG3507	Belongs to the glycosyl hydrolase 43 family
DS731_RS20445	COG3534	alpha-L-arabinofuranosidase
DS731_RS20460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DS731_RS20475	COG1069	ribulokinase activity
DS731_RS20480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DS731_RS20485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DS731_RS20500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DS731_RS20505	COG2169	Transcriptional regulator
DS731_RS20520	COG3300	MHYT domain
DS731_RS20520	COG5001	Diguanylate cyclase
DS731_RS20530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DS731_RS20535	COG1166	arginine decarboxylase activity
DS731_RS20540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DS731_RS20550	COG4771	TonB-dependent receptor
DS731_RS20555	COG0778	Nitroreductase
DS731_RS20585	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DS731_RS20595	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DS731_RS20600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DS731_RS20610	COG4191	Histidine kinase
DS731_RS20610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS731_RS20640	COG4232	protein-disulfide reductase activity
DS731_RS20660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DS731_RS20665	COG0511	ligase activity, forming carbon-carbon bonds
DS731_RS20670	COG0439	Biotin carboxylase
DS731_RS20735	COG0848	biopolymer transport protein
DS731_RS20740	COG0811	peptide transport
DS731_RS20745	COG0811	peptide transport
DS731_RS20770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DS731_RS20775	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DS731_RS20790	COG0151	Belongs to the GarS family
DS731_RS20800	COG3954	Phosphoribulokinase
DS731_RS20835	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DS731_RS20840	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DS731_RS20850	COG3031	protein transport across the cell outer membrane
DS731_RS20860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DS731_RS20865	COG1459	type II secretion system
DS731_RS20870	COG2165	general secretion pathway protein
DS731_RS20875	COG2165	general secretion pathway protein
DS731_RS20890	COG3156	type II secretion system protein K
DS731_RS20900	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
DS731_RS20915	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DS731_RS20920	COG1011	Hydrolase
DS731_RS20925	COG0494	nUDIX hydrolase
DS731_RS20930	COG1218	3'(2'),5'-bisphosphate nucleotidase
DS731_RS20945	COG2943	transferase activity, transferring hexosyl groups
DS731_RS20950	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DS731_RS20960	COG0583	DNA-binding transcription factor activity
DS731_RS20970	COG3089	Belongs to the UPF0270 family
DS731_RS20975	COG0429	hydrolase of the alpha beta-hydrolase fold
DS731_RS20985	COG0488	(ABC) transporter
DS731_RS20990	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DS731_RS21005	COG2900	Belongs to the SlyX family
DS731_RS21015	COG0545	Peptidyl-prolyl cis-trans isomerase
DS731_RS21020	COG1902	pentaerythritol trinitrate reductase activity
DS731_RS21025	COG0693	protein deglycase activity
DS731_RS21035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DS731_RS21055	COG2183	response to ionizing radiation
DS731_RS21060	COG2801	Transposase and inactivated derivatives
DS731_RS21065	COG2963	transposase activity
DS731_RS21105	COG0596	Alpha beta hydrolase
DS731_RS21130	COG0534	Mate efflux family protein
DS731_RS21150	COG0109	protoheme IX farnesyltransferase activity
DS731_RS21155	COG1612	heme a metabolic process
DS731_RS21180	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DS731_RS21185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DS731_RS21190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DS731_RS21195	COG2353	YceI-like domain
DS731_RS21210	COG0583	DNA-binding transcription factor activity
DS731_RS21225	COG1609	Transcriptional regulator
DS731_RS21230	COG4771	TonB-dependent receptor
DS731_RS21235	COG3119	arylsulfatase activity
DS731_RS21240	COG3119	arylsulfatase activity
DS731_RS21245	COG3119	arylsulfatase activity
DS731_RS21280	COG0129	dihydroxy-acid dehydratase activity
DS731_RS21295	COG0606	chelatase, subunit chli
DS731_RS21315	COG2814	Major facilitator Superfamily
DS731_RS21320	COG0729	surface antigen
DS731_RS21325	COG2911	Protein conserved in bacteria
DS731_RS21330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DS731_RS21350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DS731_RS21360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DS731_RS21380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DS731_RS21400	COG0402	S-adenosylhomocysteine deaminase activity
DS731_RS21425	COG2963	transposase activity
DS731_RS21430	COG2801	Transposase and inactivated derivatives
DS731_RS21435	COG0425	Belongs to the sulfur carrier protein TusA family
DS731_RS21440	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DS731_RS21455	COG1561	YicC-like family, N-terminal region
DS731_RS21465	COG3727	T/G mismatch-specific endonuclease activity
DS731_RS21495	COG0625	glutathione transferase activity
DS731_RS21515	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DS731_RS21535	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DS731_RS21540	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DS731_RS21560	COG1475	DNA binding
DS731_RS21565	COG1192	Involved in chromosome partitioning
DS731_RS21590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DS731_RS21605	COG0706	membrane insertase activity
DS731_RS21615	COG0594	ribonuclease P activity
DS731_RS21620	COG0230	Belongs to the bacterial ribosomal protein bL34 family