locus-tag	class	description
BM528_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BM528_RS00020	COG0187	DNA topoisomerase II activity
BM528_RS00055	COG2818	Glycosylase
BM528_RS00065	COG3078	GTPase activator activity
BM528_RS00085	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM528_RS00085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM528_RS00095	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BM528_RS00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BM528_RS00105	COG0569	domain protein
BM528_RS00110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BM528_RS00110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BM528_RS00125	COG1652	LysM domain
BM528_RS00130	COG0758	DNA mediated transformation
BM528_RS00140	COG0551	DNA topoisomerase type I activity
BM528_RS00145	COG0009	L-threonylcarbamoyladenylate synthase
BM528_RS00150	COG0408	coproporphyrinogen oxidase activity
BM528_RS00155	COG3047	cAMP biosynthetic process
BM528_RS00170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BM528_RS00235	COG2234	aminopeptidase activity
BM528_RS00250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BM528_RS00275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM528_RS00315	COG3642	lipopolysaccharide core region biosynthetic process
BM528_RS00320	COG0859	PFAM glycosyl transferase family 9
BM528_RS00350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM528_RS00365	COG3161	chorismate lyase activity
BM528_RS00370	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BM528_RS00375	COG2960	long-chain fatty acid transporting porin activity
BM528_RS00380	COG0210	DNA helicase
BM528_RS00460	COG5001	Diguanylate cyclase
BM528_RS00460	COG3300	MHYT domain
BM528_RS00490	COG3550	peptidyl-serine autophosphorylation
BM528_RS00495	COG1396	sequence-specific DNA binding
BM528_RS00550	COG3550	peptidyl-serine autophosphorylation
BM528_RS00575	COG4585	Histidine kinase
BM528_RS00580	COG2197	response regulator
BM528_RS00605	COG2855	membrane
BM528_RS00615	COG0656	L-ascorbic acid biosynthetic process
BM528_RS00630	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM528_RS00635	COG4771	TonB-dependent receptor
BM528_RS00670	COG4771	TonB-dependent receptor
BM528_RS00675	COG1960	acyl-CoA dehydrogenase activity
BM528_RS00680	COG0583	DNA-binding transcription factor activity
BM528_RS00690	COG3106	COG3106 Predicted ATPase
BM528_RS00705	COG3071	HemY protein
BM528_RS00710	COG2959	enzyme of heme biosynthesis
BM528_RS00720	COG0181	hydroxymethylbilane synthase activity
BM528_RS00730	COG0400	carboxylic ester hydrolase activity
BM528_RS00735	COG0194	GDP metabolic process
BM528_RS00745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BM528_RS00755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM528_RS00760	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BM528_RS00770	COG0678	peroxiredoxin activity
BM528_RS00785	COG1178	ABC-type Fe3 transport system permease component
BM528_RS00790	COG3842	ATPase activity
BM528_RS00795	COG2081	HI0933 family
BM528_RS00815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BM528_RS00815	COG1181	Belongs to the D-alanine--D-alanine ligase family
BM528_RS00835	COG2200	EAL domain
BM528_RS00870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM528_RS00885	COG0427	acetyl-CoA hydrolase
BM528_RS00890	COG0123	including yeast histone deacetylase and acetoin utilization protein
BM528_RS00905	COG0840	transmembrane signaling receptor activity
BM528_RS00920	COG5002	protein histidine kinase activity
BM528_RS00920	COG5001	Diguanylate cyclase
BM528_RS00935	COG0514	ATP-dependent DNA helicase (RecQ)
BM528_RS00940	COG2239	Acts as a magnesium transporter
BM528_RS00955	COG0210	DNA helicase
BM528_RS00965	COG1011	Hydrolase
BM528_RS00970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BM528_RS00980	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BM528_RS00985	COG0019	diaminopimelate decarboxylase activity
BM528_RS01000	COG0671	phosphoesterase, PA-phosphatase related
BM528_RS01015	COG0163	prenyltransferase activity
BM528_RS01020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BM528_RS01030	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BM528_RS01050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM528_RS01055	COG1136	(ABC) transporter
BM528_RS01055	COG0577	efflux transmembrane transporter activity
BM528_RS01070	COG1077	Cell shape determining protein MreB Mrl
BM528_RS01080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BM528_RS01085	COG2814	Major facilitator Superfamily
BM528_RS01105	COG1085	galactose-1-phosphate uridylyltransferase
BM528_RS01110	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BM528_RS01140	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM528_RS01165	COG1349	DNA-binding transcription factor activity
BM528_RS01180	COG1077	Cell shape determining protein MreB Mrl
BM528_RS01185	COG1792	Involved in formation and maintenance of cell shape
BM528_RS01190	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BM528_RS01200	COG1530	ribonuclease E activity
BM528_RS01205	COG3164	Protein of unknown function
BM528_RS01210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM528_RS01215	COG0312	modulator of DNA gyrase
BM528_RS01220	COG3028	Belongs to the UPF0307 family
BM528_RS01225	COG0312	modulator of DNA gyrase
BM528_RS01240	COG0745	RESPONSE REGULATOR receiver
BM528_RS01245	COG4191	Histidine kinase
BM528_RS01245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM528_RS01250	COG0297	glycogen (starch) synthase activity
BM528_RS01260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BM528_RS01265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BM528_RS01265	COG2226	methyltransferase
BM528_RS01265	COG0596	Alpha beta hydrolase
BM528_RS01305	COG3706	GGDEF domain
BM528_RS01315	COG0546	phosphoglycolate phosphatase activity
BM528_RS01330	COG1454	alcohol dehydrogenase
BM528_RS01410	COG0751	glycine-tRNA ligase activity
BM528_RS01420	COG5433	transposase activity
BM528_RS01435	COG0463	Glycosyl transferase, family 2
BM528_RS01455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM528_RS01475	COG1611	Belongs to the LOG family
BM528_RS01485	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM528_RS01485	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM528_RS01510	COG4191	Histidine kinase
BM528_RS01575	COG1773	rubredoxin
BM528_RS01595	COG2204	response regulator
BM528_RS01605	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BM528_RS01690	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BM528_RS01695	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BM528_RS01705	COG0156	8-amino-7-oxononanoate synthase activity
BM528_RS01715	COG0596	Alpha beta hydrolase
BM528_RS01720	COG0419	ATPase involved in DNA repair
BM528_RS01725	COG0420	3'-5' exonuclease activity
BM528_RS01750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BM528_RS01755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BM528_RS01760	COG3659	wide pore channel activity
BM528_RS01775	COG1739	Uncharacterized protein family UPF0029
BM528_RS01780	COG1451	nucleotide metabolic process
BM528_RS01785	COG3112	Uncharacterised protein family (UPF0231)
BM528_RS01845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BM528_RS01850	COG0051	transcription antitermination factor activity, RNA binding
BM528_RS01865	COG0089	rRNA binding
BM528_RS01875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BM528_RS01885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BM528_RS01900	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BM528_RS01905	COG1519	Transferase
BM528_RS01920	COG0840	transmembrane signaling receptor activity
BM528_RS01935	COG0788	formyltetrahydrofolate deformylase activity
BM528_RS01945	COG1643	Atp-dependent helicase
BM528_RS01950	COG3706	GGDEF domain
BM528_RS01950	COG2203	Gaf domain
BM528_RS01950	COG5001	Diguanylate cyclase
BM528_RS01950	COG4251	negative regulation of phosphorylation
BM528_RS01960	COG2951	lytic endotransglycosylase activity
BM528_RS01965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BM528_RS01975	COG2354	Protein conserved in bacteria
BM528_RS01990	COG0004	ammonium transporteR
BM528_RS01995	COG0405	Gamma-glutamyltransferase
BM528_RS02000	COG2837	iron assimilation
BM528_RS02015	COG0540	Belongs to the ATCase OTCase family
BM528_RS02025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM528_RS02040	COG4999	Histidine kinase
BM528_RS02040	COG3850	Histidine kinase
BM528_RS02040	COG2205	protein histidine kinase activity
BM528_RS02040	COG3437	response regulator, receiver
BM528_RS02055	COG5001	Diguanylate cyclase
BM528_RS02055	COG3300	MHYT domain
BM528_RS02065	COG1012	belongs to the aldehyde dehydrogenase family
BM528_RS02070	COG3138	arginine N-succinyltransferase
BM528_RS02075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BM528_RS02085	COG0512	Glutamine amidotransferase of anthranilate synthase
BM528_RS02090	COG0180	Tryptophanyl-tRNA synthetase
BM528_RS02095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BM528_RS02115	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BM528_RS02125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BM528_RS02160	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BM528_RS02165	COG0281	malic enzyme
BM528_RS02180	COG0517	IMP dehydrogenase activity
BM528_RS02195	COG0746	molybdenum cofactor guanylyltransferase activity
BM528_RS02205	COG1116	anion transmembrane transporter activity
BM528_RS02215	COG1116	anion transmembrane transporter activity
BM528_RS02215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BM528_RS02220	COG1648	precorrin-2 dehydrogenase activity
BM528_RS02220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BM528_RS02225	COG0243	molybdopterin cofactor binding
BM528_RS02235	COG2146	nitrite reductase [NAD(P)H] activity
BM528_RS02235	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BM528_RS02245	COG2116	formate transmembrane transporter activity
BM528_RS02255	COG0303	'Molybdopterin
BM528_RS02270	COG0625	glutathione transferase activity
BM528_RS02285	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BM528_RS02285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BM528_RS02295	COG0137	argininosuccinate synthase activity
BM528_RS02300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BM528_RS02315	COG1803	Methylglyoxal synthase
BM528_RS02320	COG3678	ATP-independent chaperone mediated protein folding
BM528_RS02325	COG0745	RESPONSE REGULATOR receiver
BM528_RS02340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BM528_RS02345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BM528_RS02355	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BM528_RS02360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM528_RS02365	COG4942	peptidase
BM528_RS02370	COG2861	carbohydrate metabolic process
BM528_RS02380	COG0584	glycerophosphoryl diester phosphodiesterase
BM528_RS02395	COG1162	GTPase activity
BM528_RS02400	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BM528_RS02425	COG0028	Belongs to the TPP enzyme family
BM528_RS02445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BM528_RS02450	COG0805	protein transport
BM528_RS02460	COG0084	hydrolase, TatD family'
BM528_RS02465	COG3706	GGDEF domain
BM528_RS02475	COG0248	Ppx GppA phosphatase
BM528_RS02480	COG0513	Belongs to the DEAD box helicase family
BM528_RS02485	COG3118	belongs to the thioredoxin family
BM528_RS02490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BM528_RS02495	COG1473	amidohydrolase
BM528_RS02500	COG2205	protein histidine kinase activity
BM528_RS02500	COG0784	Response regulator, receiver
BM528_RS02505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BM528_RS02510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BM528_RS02520	COG2847	Copper chaperone PCu(A)C
BM528_RS02525	COG0783	Belongs to the Dps family
BM528_RS02530	COG2133	pyrroloquinoline quinone binding
BM528_RS02535	COG4946	Tricorn protease homolog
BM528_RS02535	COG1506	peptidase
BM528_RS02535	COG0823	Involved in the tonB-independent uptake of proteins
BM528_RS02545	COG3118	belongs to the thioredoxin family
BM528_RS02560	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
BM528_RS02570	COG1012	belongs to the aldehyde dehydrogenase family
BM528_RS02590	COG1757	Na H antiporter
BM528_RS02600	COG3876	Protein conserved in bacteria
BM528_RS02605	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BM528_RS02680	COG3547	Transposase (IS116 IS110 IS902 family)
BM528_RS02780	COG0183	Belongs to the thiolase family
BM528_RS02785	COG1024	Enoyl-CoA hydratase
BM528_RS02785	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM528_RS02795	COG0006	proline dipeptidase activity
BM528_RS02805	COG0142	geranyltranstransferase activity
BM528_RS02840	COG1388	LysM domain
BM528_RS02840	COG4942	peptidase
BM528_RS02845	COG1238	metal cluster binding
BM528_RS02855	COG0585	pseudouridine synthase activity
BM528_RS02870	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BM528_RS02880	COG0840	transmembrane signaling receptor activity
BM528_RS02895	COG3025	triphosphatase activity
BM528_RS02905	COG3066	DNA modification
BM528_RS02910	COG0494	nUDIX hydrolase
BM528_RS02915	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
BM528_RS02920	COG0730	response to heat
BM528_RS02925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BM528_RS02930	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BM528_RS02935	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BM528_RS02960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM528_RS02980	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BM528_RS02985	COG2201	protein-glutamate methylesterase activity
BM528_RS02990	COG3706	GGDEF domain
BM528_RS02995	COG2211	Major facilitator Superfamily
BM528_RS03015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BM528_RS03025	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BM528_RS03035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BM528_RS03035	COG1648	precorrin-2 dehydrogenase activity
BM528_RS03040	COG0513	Belongs to the DEAD box helicase family
BM528_RS03055	COG1538	Outer membrane efflux protein
BM528_RS03060	COG0494	nUDIX hydrolase
BM528_RS03065	COG3151	Protein conserved in bacteria
BM528_RS03070	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BM528_RS03075	COG3150	esterase
BM528_RS03105	COG1509	lysine 2,3-aminomutase activity
BM528_RS03110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BM528_RS03115	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BM528_RS03150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM528_RS03165	COG0271	Belongs to the BolA IbaG family
BM528_RS03170	COG0671	phosphoesterase, PA-phosphatase related
BM528_RS03185	COG0659	secondary active sulfate transmembrane transporter activity
BM528_RS03200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BM528_RS03210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BM528_RS03220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BM528_RS03225	COG0348	domain, Protein
BM528_RS03240	COG1960	acyl-CoA dehydrogenase activity
BM528_RS03245	COG1028	Short-chain dehydrogenase reductase Sdr
BM528_RS03255	COG4948	Mandelate Racemase Muconate Lactonizing
BM528_RS03275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM528_RS03280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM528_RS03305	COG0358	DNA primase activity
BM528_RS03330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BM528_RS03350	COG0537	adenosine 5'-monophosphoramidase activity
BM528_RS03365	COG2974	May be involved in recombination
BM528_RS03375	COG0745	RESPONSE REGULATOR receiver
BM528_RS03380	COG5002	protein histidine kinase activity
BM528_RS03410	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BM528_RS03425	COG0527	aspartate kinase activity
BM528_RS03445	COG2967	ApaG domain
BM528_RS03450	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BM528_RS03455	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BM528_RS03460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM528_RS03465	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BM528_RS03470	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BM528_RS03480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BM528_RS03485	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BM528_RS03500	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BM528_RS03515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BM528_RS03520	COG3956	TIGRFAM MazG family protein
BM528_RS03545	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BM528_RS03560	COG2801	Transposase and inactivated derivatives
BM528_RS03580	COG3474	cytochrome
BM528_RS03590	COG4771	TonB-dependent receptor
BM528_RS03605	COG3119	arylsulfatase activity
BM528_RS03610	COG2814	Major facilitator Superfamily
BM528_RS03615	COG1404	Belongs to the peptidase S8 family
BM528_RS03620	COG1132	(ABC) transporter
BM528_RS03635	COG0318	PFAM AMP-dependent synthetase and ligase
BM528_RS03660	COG1012	belongs to the aldehyde dehydrogenase family
BM528_RS03680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BM528_RS03705	COG0723	plastoquinol--plastocyanin reductase activity
BM528_RS03710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BM528_RS03715	COG2857	Cytochrome c1
BM528_RS03720	COG0625	glutathione transferase activity
BM528_RS03725	COG2969	positive regulation of protein catabolic process
BM528_RS03730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM528_RS03745	COG2239	Acts as a magnesium transporter
BM528_RS03750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BM528_RS03770	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BM528_RS03775	COG1137	ATPase activity
BM528_RS03780	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BM528_RS03805	COG1127	ABC transporter
BM528_RS03810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BM528_RS03815	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BM528_RS03820	COG2854	intermembrane phospholipid transfer
BM528_RS03830	COG5007	Belongs to the BolA IbaG family
BM528_RS03840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM528_RS03845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM528_RS03855	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BM528_RS03890	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BM528_RS03905	COG3706	GGDEF domain
BM528_RS03910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BM528_RS03915	COG0612	Peptidase, M16
BM528_RS03925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM528_RS03950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BM528_RS03960	COG0126	phosphoglycerate kinase activity
BM528_RS03965	COG3588	fructose-bisphosphate aldolase
BM528_RS03970	COG0823	Involved in the tonB-independent uptake of proteins
BM528_RS03970	COG1506	peptidase
BM528_RS03970	COG4946	Tricorn protease homolog
BM528_RS03975	COG2311	Membrane
BM528_RS03980	COG0248	Ppx GppA phosphatase
BM528_RS03985	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BM528_RS03995	COG0573	inorganic phosphate transmembrane transporter activity
BM528_RS04005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BM528_RS04015	COG0306	phosphate transporter
BM528_RS04020	COG0589	response to stress
BM528_RS04025	COG0583	DNA-binding transcription factor activity
BM528_RS04035	COG1272	protein, Hemolysin III
BM528_RS04045	COG1846	Transcriptional regulator
BM528_RS04050	COG1764	response to oxidative stress
BM528_RS04070	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BM528_RS04100	COG1346	cytolysis
BM528_RS04130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BM528_RS04135	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BM528_RS04140	COG0513	Belongs to the DEAD box helicase family
BM528_RS04145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM528_RS04155	COG3267	Type II secretory pathway component ExeA
BM528_RS04155	COG3409	Peptidoglycan-binding domain 1 protein
BM528_RS04170	COG1757	Na H antiporter
BM528_RS04175	COG0066	3-isopropylmalate dehydratase activity
BM528_RS04185	COG0473	3-isopropylmalate dehydrogenase activity
BM528_RS04190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BM528_RS04210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BM528_RS04225	COG4555	ABC transporter
BM528_RS04230	COG1668	transmembrane transport
BM528_RS04245	COG4133	protoheme IX ABC transporter activity
BM528_RS04250	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM528_RS04255	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM528_RS04260	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM528_RS04270	COG1138	Cytochrome C-type biogenesis protein
BM528_RS04290	COG2853	Lipoprotein
BM528_RS04295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BM528_RS04310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BM528_RS04315	COG1555	photosystem II stabilization
BM528_RS04315	COG1596	polysaccharide export
BM528_RS04320	COG0473	3-isopropylmalate dehydrogenase activity
BM528_RS04340	COG1611	Belongs to the LOG family
BM528_RS04350	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM528_RS04350	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM528_RS04395	COG0811	peptide transport
BM528_RS04400	COG0811	peptide transport
BM528_RS04405	COG0848	biopolymer transport protein
BM528_RS04410	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BM528_RS04420	COG3437	response regulator, receiver
BM528_RS04425	COG2205	protein histidine kinase activity
BM528_RS04425	COG5002	protein histidine kinase activity
BM528_RS04425	COG0784	Response regulator, receiver
BM528_RS04445	COG2133	pyrroloquinoline quinone binding
BM528_RS04450	COG1049	propionate catabolic process, 2-methylcitrate cycle
BM528_RS04495	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BM528_RS04500	COG0024	Methionine aminopeptidase
BM528_RS04505	COG0052	Belongs to the universal ribosomal protein uS2 family
BM528_RS04515	COG0528	UMP kinase activity
BM528_RS04525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BM528_RS04530	COG0575	Belongs to the CDS family
BM528_RS04535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BM528_RS04555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BM528_RS04575	COG0587	DNA-directed DNA polymerase activity
BM528_RS04580	COG0825	malonyl-CoA metabolic process
BM528_RS04585	COG0037	tRNA processing
BM528_RS04590	COG3706	GGDEF domain
BM528_RS04610	COG0513	Belongs to the DEAD box helicase family
BM528_RS04615	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BM528_RS04620	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BM528_RS04625	COG0583	DNA-binding transcription factor activity
BM528_RS04645	COG1760	l-serine dehydratase
BM528_RS04655	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BM528_RS04665	COG1322	Protein conserved in bacteria
BM528_RS04680	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BM528_RS04685	COG0022	dehydrogenase e1 component
BM528_RS04695	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BM528_RS04705	COG1946	Acyl-CoA thioesterase
BM528_RS04720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BM528_RS04730	COG1956	GAF domain-containing protein
BM528_RS04745	COG0793	Belongs to the peptidase S41A family
BM528_RS04750	COG0733	neurotransmitter:sodium symporter activity
BM528_RS04755	COG1757	Na H antiporter
BM528_RS04760	COG0308	aminopeptidase N
BM528_RS04790	COG2902	Dehydrogenase
BM528_RS04795	COG0167	dihydroorotate dehydrogenase activity
BM528_RS04810	COG0488	(ABC) transporter
BM528_RS04820	COG3130	regulation of translation
BM528_RS04825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BM528_RS04835	COG0415	Belongs to the DNA photolyase family
BM528_RS04845	COG0415	Belongs to the DNA photolyase family
BM528_RS04850	COG0415	Belongs to the DNA photolyase family
BM528_RS04855	COG3046	protein related to deoxyribodipyrimidine photolyase
BM528_RS04870	COG1757	Na H antiporter
BM528_RS04900	COG5002	protein histidine kinase activity
BM528_RS04905	COG0745	RESPONSE REGULATOR receiver
BM528_RS04930	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM528_RS04975	COG1028	Short-chain dehydrogenase reductase Sdr
BM528_RS05050	COG0375	protein maturation
BM528_RS05060	COG0409	Hydrogenase expression formation protein
BM528_RS05070	COG0309	Hydrogenase expression formation protein (HypE)
BM528_RS05075	COG0789	Transcriptional regulator
BM528_RS05080	COG2217	Heavy metal translocating P-type atpase
BM528_RS05110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BM528_RS05145	COG0589	response to stress
BM528_RS05155	COG0069	glutamate synthase activity
BM528_RS05160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BM528_RS05160	COG4651	solute:proton antiporter activity
BM528_RS05170	COG2193	ferroxidase activity
BM528_RS05185	COG3278	Belongs to the heme-copper respiratory oxidase family
BM528_RS05200	COG2010	Cytochrome c
BM528_RS05230	COG0589	response to stress
BM528_RS05235	COG0037	tRNA processing
BM528_RS05240	COG1752	Esterase of the alpha-beta hydrolase superfamily
BM528_RS05260	COG1280	lysine exporter protein (LysE YggA)
BM528_RS05270	COG2897	thiosulfate sulfurtransferase activity
BM528_RS05275	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BM528_RS05280	COG3148	PFAM DTW domain containing protein
BM528_RS05285	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BM528_RS05315	COG0322	excinuclease ABC activity
BM528_RS05320	COG2197	response regulator
BM528_RS05335	COG0670	Belongs to the BI1 family
BM528_RS05340	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BM528_RS05355	COG2920	part of a sulfur-relay system
BM528_RS05365	COG4191	Histidine kinase
BM528_RS05370	COG0840	transmembrane signaling receptor activity
BM528_RS05385	COG3447	MASE1 domain protein
BM528_RS05385	COG5001	Diguanylate cyclase
BM528_RS05385	COG5002	protein histidine kinase activity
BM528_RS05410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BM528_RS05415	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BM528_RS05420	COG0531	amino acid
BM528_RS05420	COG1674	ftsk spoiiie
BM528_RS05430	COG0686	Belongs to the AlaDH PNT family
BM528_RS05435	COG0284	orotidine-5'-phosphate decarboxylase activity
BM528_RS05440	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BM528_RS05445	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
BM528_RS05455	COG0776	regulation of translation
BM528_RS05460	COG0539	negative regulation of cytoplasmic translation
BM528_RS05465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BM528_RS05470	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BM528_RS05475	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BM528_RS05490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BM528_RS05495	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BM528_RS05500	COG0633	Ferredoxin
BM528_RS05515	COG2200	EAL domain
BM528_RS05540	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BM528_RS05545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BM528_RS05555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BM528_RS05565	COG4783	chaperone-mediated protein folding
BM528_RS05575	COG1393	Belongs to the ArsC family
BM528_RS05590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BM528_RS05605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BM528_RS05615	COG1960	acyl-CoA dehydrogenase activity
BM528_RS05635	COG0572	uridine kinase
BM528_RS05640	COG3769	mannosylglycerate metabolic process
BM528_RS05645	COG1215	transferase activity, transferring glycosyl groups
BM528_RS05660	COG0303	'Molybdopterin
BM528_RS05665	COG0534	Mate efflux family protein
BM528_RS05675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM528_RS05680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BM528_RS05690	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BM528_RS05710	COG1448	Aminotransferase
BM528_RS05745	COG1671	Belongs to the UPF0178 family
BM528_RS05750	COG1028	Short-chain dehydrogenase reductase Sdr
BM528_RS05755	COG1028	Short-chain dehydrogenase reductase Sdr
BM528_RS05760	COG2130	NADP-dependent
BM528_RS05765	COG1960	acyl-CoA dehydrogenase activity
BM528_RS05770	COG2207	Transcriptional regulator
BM528_RS05770	COG0662	Cupin 2, conserved barrel domain protein
BM528_RS05785	COG1505	serine-type exopeptidase activity
BM528_RS05825	COG0596	Alpha beta hydrolase
BM528_RS05835	COG0716	FMN binding
BM528_RS05845	COG0735	belongs to the Fur family
BM528_RS05855	COG1984	allophanate hydrolase subunit 2
BM528_RS05865	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BM528_RS05870	COG2996	Protein conserved in bacteria
BM528_RS05875	COG1765	OsmC-like protein
BM528_RS05880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM528_RS05890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM528_RS05905	COG0436	Aminotransferase
BM528_RS05910	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BM528_RS05915	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BM528_RS05930	COG1238	metal cluster binding
BM528_RS05940	COG3012	SEC-C Motif Domain Protein
BM528_RS05960	COG0702	epimerase
BM528_RS05970	COG0084	hydrolase, TatD family'
BM528_RS05985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BM528_RS05990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BM528_RS05995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BM528_RS06000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BM528_RS06015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BM528_RS06020	COG0416	fatty acid biosynthetic process
BM528_RS06030	COG1399	metal-binding, possibly nucleic acid-binding protein
BM528_RS06040	COG0546	phosphoglycolate phosphatase activity
BM528_RS06050	COG1530	ribonuclease E activity
BM528_RS06060	COG5002	protein histidine kinase activity
BM528_RS06075	COG3708	Transcriptional regulator
BM528_RS06075	COG2207	Transcriptional regulator
BM528_RS06080	COG0612	Peptidase, M16
BM528_RS06095	COG1185	polyribonucleotide nucleotidyltransferase activity
BM528_RS06110	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BM528_RS06115	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BM528_RS06120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM528_RS06135	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BM528_RS06140	COG0149	triose-phosphate isomerase activity
BM528_RS06145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BM528_RS06150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BM528_RS06155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM528_RS06160	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BM528_RS06165	COG1534	Rna-binding protein
BM528_RS06175	COG1067	ATP-dependent peptidase activity
BM528_RS06180	COG0495	leucyl-tRNA aminoacylation
BM528_RS06195	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BM528_RS06200	COG0799	negative regulation of ribosome biogenesis
BM528_RS06205	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BM528_RS06210	COG0768	penicillin binding
BM528_RS06215	COG0772	Belongs to the SEDS family
BM528_RS06220	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BM528_RS06225	COG1686	Belongs to the peptidase S11 family
BM528_RS06230	COG2921	Belongs to the UPF0250 family
BM528_RS06235	COG0321	lipoyl(octanoyl) transferase activity
BM528_RS06240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BM528_RS06245	COG0252	asparaginase activity
BM528_RS06255	COG0778	Nitroreductase
BM528_RS06265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM528_RS06275	COG0616	signal peptide processing
BM528_RS06280	COG3091	SprT-like family
BM528_RS06285	COG3092	negative regulation of chromosome organization
BM528_RS06290	COG0492	ferredoxin-NADP+ reductase activity
BM528_RS06295	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BM528_RS06300	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BM528_RS06305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BM528_RS06310	COG0542	response to heat
BM528_RS06315	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BM528_RS06320	COG1278	Cold shock
BM528_RS06335	COG1187	pseudouridine synthase activity
BM528_RS06340	COG0482	sulfurtransferase activity
BM528_RS06345	COG2915	High frequency lysogenization protein hflD homolog
BM528_RS06350	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BM528_RS06355	COG2850	peptidyl-arginine hydroxylation
BM528_RS06370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BM528_RS06370	COG0574	Belongs to the PEP-utilizing enzyme family
BM528_RS06380	COG0457	Tetratricopeptide repeat
BM528_RS06385	COG2153	protein acetylation
BM528_RS06395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BM528_RS06400	COG3724	N-succinylarginine dihydrolase activity
BM528_RS06410	COG1301	dicarboxylic acid transport
BM528_RS06415	COG4591	ABC-type transport system involved in lipoprotein release permease component
BM528_RS06420	COG1136	(ABC) transporter
BM528_RS06425	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BM528_RS06460	COG0328	RNA-DNA hybrid ribonuclease activity
BM528_RS06465	COG3321	synthase
BM528_RS06465	COG0604	alcohol dehydrogenase
BM528_RS06485	COG1643	Atp-dependent helicase
BM528_RS06500	COG2925	Exonuclease
BM528_RS06525	COG0183	Belongs to the thiolase family
BM528_RS06530	COG0789	Transcriptional regulator
BM528_RS06535	COG1960	acyl-CoA dehydrogenase activity
BM528_RS06540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BM528_RS06545	COG1024	Enoyl-CoA hydratase
BM528_RS06550	COG4770	biotin carboxylase activity
BM528_RS06585	COG2814	Major facilitator Superfamily
BM528_RS06645	COG4591	ABC-type transport system involved in lipoprotein release permease component
BM528_RS06655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BM528_RS06665	COG2096	Adenosyltransferase
BM528_RS06675	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BM528_RS06685	COG1472	Belongs to the glycosyl hydrolase 3 family
BM528_RS06710	COG0072	phenylalanine-tRNA ligase activity
BM528_RS06710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM528_RS06730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BM528_RS06740	COG3001	Fructosamine kinase
BM528_RS06760	COG0154	amidase activity
BM528_RS06770	COG0730	response to heat
BM528_RS06775	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BM528_RS06790	COG2233	PERMEase
BM528_RS06805	COG0784	Response regulator, receiver
BM528_RS06805	COG2205	protein histidine kinase activity
BM528_RS06810	COG3706	GGDEF domain
BM528_RS06810	COG5001	Diguanylate cyclase
BM528_RS06810	COG2203	Gaf domain
BM528_RS06810	COG4251	negative regulation of phosphorylation
BM528_RS06820	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BM528_RS06825	COG2252	PERMEase
BM528_RS06840	COG1309	transcriptional regulator
BM528_RS06850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BM528_RS06865	COG2351	hydroxyisourate hydrolase activity
BM528_RS06870	COG0402	S-adenosylhomocysteine deaminase activity
BM528_RS06880	COG0745	RESPONSE REGULATOR receiver
BM528_RS06895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BM528_RS06950	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BM528_RS06975	COG1393	Belongs to the ArsC family
BM528_RS07010	COG2988	succinylglutamate desuccinylase activity
BM528_RS07025	COG0330	HflC and HflK could
BM528_RS07035	COG0058	SHG alpha-glucan phosphorylase activity
BM528_RS07040	COG0033	Phosphoglucomutase
BM528_RS07045	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
BM528_RS07050	COG0714	Associated with various cellular activities
BM528_RS07070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BM528_RS07080	COG2363	Small membrane protein
BM528_RS07090	COG0583	DNA-binding transcription factor activity
BM528_RS07100	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BM528_RS07110	COG3437	response regulator, receiver
BM528_RS07110	COG0784	Response regulator, receiver
BM528_RS07115	COG2890	protein-(glutamine-N5) methyltransferase activity
BM528_RS07125	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BM528_RS07130	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BM528_RS07135	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BM528_RS07145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BM528_RS07155	COG1064	alcohol dehydrogenase
BM528_RS07165	COG1064	alcohol dehydrogenase
BM528_RS07180	COG0012	GTP binding
BM528_RS07225	COG1115	amino acid carrier protein
BM528_RS07245	COG1199	ATP-dependent helicase activity
BM528_RS07280	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BM528_RS07285	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BM528_RS07290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM528_RS07295	COG0131	Imidazoleglycerol-phosphate dehydratase
BM528_RS07295	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BM528_RS07300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BM528_RS07330	COG0326	Molecular chaperone. Has ATPase activity
BM528_RS07335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BM528_RS07355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BM528_RS07365	COG3220	belongs to the UPF0276 family
BM528_RS07405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM528_RS07415	COG1702	phosphate starvation-inducible protein PhoH
BM528_RS07425	COG4535	Mg2 and Co2 transporter CorC
BM528_RS07430	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BM528_RS07440	COG1181	Belongs to the D-alanine--D-alanine ligase family
BM528_RS07440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BM528_RS07450	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
BM528_RS07455	COG2944	sequence-specific DNA binding
BM528_RS07470	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BM528_RS07485	COG0857	belongs to the CobB CobQ family
BM528_RS07485	COG0280	phosphate acetyltransferase
BM528_RS07490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BM528_RS07495	COG0071	Belongs to the small heat shock protein (HSP20) family
BM528_RS07505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BM528_RS07510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BM528_RS07520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BM528_RS07535	COG3909	cytochrome
BM528_RS07545	COG0484	heat shock protein binding
BM528_RS07555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BM528_RS07565	COG5002	protein histidine kinase activity
BM528_RS07565	COG0784	Response regulator, receiver
BM528_RS07570	COG3562	capsule polysaccharide
BM528_RS07590	COG0625	glutathione transferase activity
BM528_RS07605	COG2610	gluconate transmembrane transporter activity
BM528_RS07610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BM528_RS07620	COG1028	Short-chain dehydrogenase reductase Sdr
BM528_RS07625	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BM528_RS07630	COG0783	Belongs to the Dps family
BM528_RS07640	COG0497	DNA recombination
BM528_RS07645	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM528_RS07650	COG0500	methyltransferase
BM528_RS07660	COG1629	transport
BM528_RS07660	COG4774	siderophore transport
BM528_RS07670	COG0534	Mate efflux family protein
BM528_RS07675	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BM528_RS07680	COG2733	membrane
BM528_RS07690	COG0110	maltose O-acetyltransferase activity
BM528_RS07705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BM528_RS07720	COG0656	L-ascorbic acid biosynthetic process
BM528_RS07725	COG1187	pseudouridine synthase activity
BM528_RS07730	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BM528_RS07740	COG0009	L-threonylcarbamoyladenylate synthase
BM528_RS07745	COG0613	PHP domain protein
BM528_RS07750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BM528_RS07760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BM528_RS07765	COG0135	phosphoribosylanthranilate isomerase activity
BM528_RS07765	COG0134	indole-3-glycerol-phosphate synthase activity
BM528_RS07775	COG0159	tryptophan synthase activity
BM528_RS07780	COG2350	Protein conserved in bacteria
BM528_RS07805	COG0628	permease
BM528_RS07810	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BM528_RS07815	COG1090	epimerase
BM528_RS07820	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BM528_RS07825	COG4181	ATPase activity
BM528_RS07830	COG2755	lipolytic protein G-D-S-L family
BM528_RS07850	COG0402	S-adenosylhomocysteine deaminase activity
BM528_RS07855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM528_RS07895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM528_RS07920	COG0745	RESPONSE REGULATOR receiver
BM528_RS07925	COG0784	Response regulator, receiver
BM528_RS07925	COG2205	protein histidine kinase activity
BM528_RS07925	COG5002	protein histidine kinase activity
BM528_RS07945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BM528_RS07950	COG5265	(ABC) transporter
BM528_RS07965	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BM528_RS07970	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BM528_RS07975	COG4139	cobalamin transport
BM528_RS07980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BM528_RS07985	COG3340	Belongs to the peptidase S51 family
BM528_RS07995	COG2226	methyltransferase
BM528_RS07995	COG1073	alpha beta
BM528_RS08000	COG0156	8-amino-7-oxononanoate synthase activity
BM528_RS08055	COG0017	Asparaginyl-tRNA synthetase
BM528_RS08060	COG2031	fatty acid transporter
BM528_RS08070	COG2995	paraquat-inducible protein a
BM528_RS08075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BM528_RS08075	COG3008	intermembrane lipid transfer
BM528_RS08085	COG3706	GGDEF domain
BM528_RS08105	COG1309	transcriptional regulator
BM528_RS08115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM528_RS08180	COG1401	restriction endodeoxyribonuclease activity
BM528_RS08235	COG1484	DNA-dependent DNA replication
BM528_RS08250	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BM528_RS08275	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
BM528_RS08280	COG2885	chlorophyll binding
BM528_RS08285	COG0823	Involved in the tonB-independent uptake of proteins
BM528_RS08300	COG0811	peptide transport
BM528_RS08305	COG0824	Thioesterase
BM528_RS08310	COG2255	four-way junction helicase activity
BM528_RS08315	COG0632	four-way junction helicase activity
BM528_RS08320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BM528_RS08325	COG0494	nUDIX hydrolase
BM528_RS08330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BM528_RS08340	COG2204	response regulator
BM528_RS08350	COG2205	protein histidine kinase activity
BM528_RS08380	COG0023	Translation Initiation Factor
BM528_RS08385	COG0745	RESPONSE REGULATOR receiver
BM528_RS08390	COG1605	Chorismate mutase
BM528_RS08390	COG0077	Prephenate dehydratase
BM528_RS08395	COG1605	Chorismate mutase
BM528_RS08395	COG0287	Prephenate dehydrogenase
BM528_RS08400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BM528_RS08410	COG2860	membrane
BM528_RS08415	COG0335	large ribosomal subunit rRNA binding
BM528_RS08420	COG0336	Belongs to the RNA methyltransferase TrmD family
BM528_RS08425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BM528_RS08430	COG0228	four-way junction DNA binding
BM528_RS08440	COG0668	transmembrane transport
BM528_RS08445	COG1132	(ABC) transporter
BM528_RS08455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM528_RS08485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BM528_RS08490	COG4137	Cytochrome C assembly protein
BM528_RS08495	COG4536	flavin adenine dinucleotide binding
BM528_RS08505	COG2062	phosphohistidine phosphatase, SixA
BM528_RS08510	COG1025	Belongs to the peptidase M16 family
BM528_RS08530	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM528_RS08530	COG1024	Enoyl-CoA hydratase
BM528_RS08540	COG0714	Associated with various cellular activities
BM528_RS08560	COG2304	oxidoreductase activity
BM528_RS08590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM528_RS08595	COG0175	sulfate reduction
BM528_RS08600	COG0529	Catalyzes the synthesis of activated sulfate
BM528_RS08615	COG3273	potassium ion transport
BM528_RS08615	COG0471	metal ion transport
BM528_RS08635	COG0367	asparagine synthase
BM528_RS08645	COG0602	queuosine metabolic process
BM528_RS08670	COG0556	nucleotide-excision repair
BM528_RS08675	COG0534	Mate efflux family protein
BM528_RS08690	COG4657	Part of a membrane complex involved in electron transport
BM528_RS08695	COG2878	Part of a membrane complex involved in electron transport
BM528_RS08700	COG4656	Part of a membrane complex involved in electron transport
BM528_RS08705	COG4658	electron transport chain
BM528_RS08710	COG4659	FMN binding
BM528_RS08715	COG4660	Part of a membrane complex involved in electron transport
BM528_RS08720	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BM528_RS08735	COG1278	Cold shock
BM528_RS08740	COG0346	lactoylglutathione lyase activity
BM528_RS08745	COG0584	glycerophosphoryl diester phosphodiesterase
BM528_RS08780	COG4771	TonB-dependent receptor
BM528_RS08785	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BM528_RS08790	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BM528_RS08805	COG2719	SpoVR family
BM528_RS08810	COG2718	Belongs to the UPF0229 family
BM528_RS08815	COG2766	serine protein kinase
BM528_RS08830	COG2890	protein-(glutamine-N5) methyltransferase activity
BM528_RS08835	COG2840	Smr protein MutS2
BM528_RS08845	COG2918	glutathione biosynthetic process
BM528_RS08850	COG0612	Peptidase, M16
BM528_RS08860	COG0564	pseudouridine synthase activity
BM528_RS08865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BM528_RS08870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BM528_RS08910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BM528_RS08925	COG3550	peptidyl-serine autophosphorylation
BM528_RS08960	COG0668	transmembrane transport
BM528_RS08970	COG4584	PFAM Integrase catalytic
BM528_RS09005	COG4584	PFAM Integrase catalytic
BM528_RS09010	COG1484	DNA-dependent DNA replication
BM528_RS09035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BM528_RS09130	COG4584	PFAM Integrase catalytic
BM528_RS09135	COG1484	DNA-dependent DNA replication
BM528_RS09185	COG0789	Transcriptional regulator
BM528_RS09200	COG0789	Transcriptional regulator
BM528_RS09210	COG0640	Transcriptional regulator
BM528_RS09220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM528_RS09230	COG1230	cation diffusion facilitator family transporter
BM528_RS09280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM528_RS09305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BM528_RS09320	COG0681	Belongs to the peptidase S26 family
BM528_RS09340	COG1074	ATP-dependent DNA helicase activity
BM528_RS09350	COG1404	Belongs to the peptidase S8 family
BM528_RS09355	COG0464	growth
BM528_RS09375	COG0629	single-stranded DNA binding
BM528_RS09390	COG0714	Associated with various cellular activities
BM528_RS09415	COG2003	Belongs to the UPF0758 family
BM528_RS09435	COG0583	DNA-binding transcription factor activity
BM528_RS09515	COG3550	peptidyl-serine autophosphorylation
BM528_RS09520	COG3620	sequence-specific DNA binding
BM528_RS09540	COG0456	acetyltransferase
BM528_RS09580	COG1444	tRNA N-acetyltransferase activity
BM528_RS09595	COG0848	biopolymer transport protein
BM528_RS09600	COG0811	peptide transport
BM528_RS09605	COG0811	peptide transport
BM528_RS09645	COG1522	sequence-specific DNA binding
BM528_RS09650	COG0625	glutathione transferase activity
BM528_RS09665	COG3186	Phenylalanine-4-hydroxylase
BM528_RS09680	COG1842	Phage shock protein A
BM528_RS09685	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BM528_RS09690	COG0747	negative chemotaxis
BM528_RS09695	COG4168	peptide transport system, permease
BM528_RS09700	COG4171	peptide transport system, permease
BM528_RS09710	COG4172	Belongs to the ABC transporter superfamily
BM528_RS09715	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BM528_RS09720	COG5016	pyruvate
BM528_RS09720	COG0511	ligase activity, forming carbon-carbon bonds
BM528_RS09750	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BM528_RS09765	COG3590	peptidase
BM528_RS09770	COG1309	transcriptional regulator
BM528_RS09775	COG0659	secondary active sulfate transmembrane transporter activity
BM528_RS09780	COG0288	reversible hydration of carbon dioxide
BM528_RS09785	COG0583	DNA-binding transcription factor activity
BM528_RS09790	COG0583	DNA-binding transcription factor activity
BM528_RS09795	COG3123	guanosine phosphorylase activity
BM528_RS09820	COG0835	chemotaxis
BM528_RS09830	COG1192	Involved in chromosome partitioning
BM528_RS09840	COG2198	Histidine kinase
BM528_RS09840	COG0643	Histidine kinase
BM528_RS09840	COG0784	Response regulator, receiver
BM528_RS09845	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BM528_RS09870	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BM528_RS09885	COG1987	bacterial-type flagellum assembly
BM528_RS09935	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BM528_RS09940	COG1766	The M ring may be actively involved in energy transduction
BM528_RS09945	COG1677	Flagellar hook-basal body complex protein FliE
BM528_RS09970	COG1086	Polysaccharide biosynthesis protein
BM528_RS09975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BM528_RS09980	COG1083	cytidylyl-transferase
BM528_RS09995	COG2089	acid synthase
BM528_RS10005	COG0318	PFAM AMP-dependent synthetase and ligase
BM528_RS10020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BM528_RS10025	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BM528_RS10025	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BM528_RS10030	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BM528_RS10045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM528_RS10050	COG3959	Transketolase, thiamine diphosphate binding domain
BM528_RS10055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BM528_RS10085	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BM528_RS10125	COG1705	Flagellar rod assembly protein muramidase FlgJ
BM528_RS10125	COG3951	Flagellar rod assembly protein muramidase FlgJ
BM528_RS10145	COG4787	bacterial-type flagellum-dependent cell motility
BM528_RS10155	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BM528_RS10165	COG1815	bacterial-type flagellum-dependent cell motility
BM528_RS10170	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BM528_RS10175	COG0835	chemotaxis
BM528_RS10175	COG0784	Response regulator, receiver
BM528_RS10210	COG2840	Smr protein MutS2
BM528_RS10215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BM528_RS10215	COG0047	phosphoribosylformylglycinamidine synthase activity
BM528_RS10240	COG1054	Belongs to the UPF0176 family
BM528_RS10250	COG0745	RESPONSE REGULATOR receiver
BM528_RS10260	COG0205	6-phosphofructokinase activity
BM528_RS10265	COG3279	Response regulator of the LytR AlgR family
BM528_RS10270	COG3275	phosphorelay sensor kinase activity
BM528_RS10290	COG0739	heme binding
BM528_RS10300	COG3081	Nucleoid-associated protein
BM528_RS10305	COG3082	Protein of unknown function (DUF1414)
BM528_RS10310	COG3083	sulfuric ester hydrolase activity
BM528_RS10315	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BM528_RS10320	COG2226	methyltransferase
BM528_RS10325	COG1024	Enoyl-CoA hydratase
BM528_RS10330	COG1960	acyl-CoA dehydrogenase activity
BM528_RS10340	COG2084	Dehydrogenase
BM528_RS10345	COG0386	Belongs to the glutathione peroxidase family
BM528_RS10350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BM528_RS10355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM528_RS10360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BM528_RS10370	COG0616	signal peptide processing
BM528_RS10375	COG2267	carboxylic ester hydrolase activity
BM528_RS10380	COG1028	Short-chain dehydrogenase reductase Sdr
BM528_RS10405	COG0366	Alpha amylase catalytic
BM528_RS10425	COG4667	esterase of the alpha-beta hydrolase superfamily
BM528_RS10455	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM528_RS10460	COG0567	Dehydrogenase, E1 component
BM528_RS10465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BM528_RS10470	COG1053	succinate dehydrogenase
BM528_RS10475	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BM528_RS10500	COG0435	Glutathione S-transferase
BM528_RS10505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BM528_RS10540	COG1663	tetraacyldisaccharide 4'-kinase activity
BM528_RS10545	COG1132	(ABC) transporter
BM528_RS10550	COG0658	competence protein
BM528_RS10550	COG2333	competence protein COMEC
BM528_RS10560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BM528_RS10570	COG1196	nuclear chromosome segregation
BM528_RS10590	COG0295	cytidine deaminase activity
BM528_RS10595	COG0405	Gamma-glutamyltransferase
BM528_RS10600	COG1024	Enoyl-CoA hydratase
BM528_RS10620	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BM528_RS10625	COG4771	TonB-dependent receptor
BM528_RS10630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BM528_RS10640	COG2914	Belongs to the UPF0125 (RnfH) family
BM528_RS10645	COG2867	negative regulation of translational initiation
BM528_RS10655	COG1902	pentaerythritol trinitrate reductase activity
BM528_RS10665	COG2814	Major facilitator Superfamily
BM528_RS10670	COG4771	TonB-dependent receptor
BM528_RS10675	COG4251	negative regulation of phosphorylation
BM528_RS10675	COG3706	GGDEF domain
BM528_RS10675	COG2203	Gaf domain
BM528_RS10675	COG5001	Diguanylate cyclase
BM528_RS10685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BM528_RS10690	COG4136	ATPase activity
BM528_RS10700	COG4134	Bacterial extracellular solute-binding protein
BM528_RS10710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM528_RS10730	COG1032	radical SAM domain protein
BM528_RS10765	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BM528_RS10795	COG0501	Belongs to the peptidase M48B family
BM528_RS10840	COG3153	acetyltransferase
BM528_RS10840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM528_RS10860	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BM528_RS10875	COG0195	Participates in both transcription termination and antitermination
BM528_RS10885	COG3437	response regulator, receiver
BM528_RS10890	COG0784	Response regulator, receiver
BM528_RS10890	COG2198	Histidine kinase
BM528_RS10890	COG2205	protein histidine kinase activity
BM528_RS10910	COG4771	TonB-dependent receptor
BM528_RS10940	COG0596	Alpha beta hydrolase
BM528_RS10945	COG1960	acyl-CoA dehydrogenase activity
BM528_RS10950	COG0183	Belongs to the thiolase family
BM528_RS10955	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM528_RS10955	COG1024	Enoyl-CoA hydratase
BM528_RS10960	COG0596	Alpha beta hydrolase
BM528_RS10970	COG0604	alcohol dehydrogenase
BM528_RS11005	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BM528_RS11025	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BM528_RS11035	COG0521	Mo-molybdopterin cofactor biosynthetic process
BM528_RS11040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BM528_RS11050	COG0436	Aminotransferase
BM528_RS11055	COG3268	Saccharopine dehydrogenase
BM528_RS11060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BM528_RS11085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM528_RS11090	COG1074	ATP-dependent DNA helicase activity
BM528_RS11095	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BM528_RS11110	COG1022	Amp-dependent synthetase and ligase
BM528_RS11115	COG3300	MHYT domain
BM528_RS11115	COG5001	Diguanylate cyclase
BM528_RS11155	COG0583	DNA-binding transcription factor activity
BM528_RS11160	COG2204	response regulator
BM528_RS11170	COG4251	negative regulation of phosphorylation
BM528_RS11175	COG0784	Response regulator, receiver
BM528_RS11180	COG2205	protein histidine kinase activity
BM528_RS11180	COG0784	Response regulator, receiver
BM528_RS11210	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BM528_RS11235	COG3139	Protein of unknown function (DUF1315)
BM528_RS11245	COG1115	amino acid carrier protein
BM528_RS11250	COG2866	Carboxypeptidase
BM528_RS11270	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BM528_RS11280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BM528_RS11285	COG1640	4-alpha-glucanotransferase
BM528_RS11295	COG0676	glucose-6-phosphate 1-epimerase activity
BM528_RS11300	COG0800	Aldolase
BM528_RS11310	COG0129	dihydroxy-acid dehydratase activity
BM528_RS11320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BM528_RS11325	COG1737	Transcriptional regulator
BM528_RS11330	COG0469	pyruvate kinase activity
BM528_RS11390	COG1741	Belongs to the pirin family
BM528_RS11400	COG1278	Cold shock
BM528_RS11410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM528_RS11415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM528_RS11420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BM528_RS11445	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BM528_RS11450	COG3177	Filamentation induced by cAMP protein fic
BM528_RS11455	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BM528_RS11545	COG0471	metal ion transport
BM528_RS11560	COG0489	protein tyrosine kinase activity
BM528_RS11565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM528_RS11565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM528_RS11570	COG2226	methyltransferase
BM528_RS11575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM528_RS11580	COG0741	lytic transglycosylase activity
BM528_RS11580	COG1388	LysM domain
BM528_RS11600	COG0545	Peptidyl-prolyl cis-trans isomerase
BM528_RS11610	COG1028	Short-chain dehydrogenase reductase Sdr
BM528_RS11620	COG0318	PFAM AMP-dependent synthetase and ligase
BM528_RS11645	COG0642	Histidine kinase
BM528_RS11660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM528_RS11665	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BM528_RS11670	COG1785	Belongs to the alkaline phosphatase family
BM528_RS11675	COG1785	Belongs to the alkaline phosphatase family
BM528_RS11735	COG1733	regulation of RNA biosynthetic process
BM528_RS11740	COG0604	alcohol dehydrogenase
BM528_RS11745	COG2205	protein histidine kinase activity
BM528_RS11745	COG0784	Response regulator, receiver
BM528_RS11750	COG0604	alcohol dehydrogenase
BM528_RS11775	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BM528_RS11780	COG1286	toxin biosynthetic process
BM528_RS11785	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
BM528_RS11790	COG0285	dihydrofolate synthase activity
BM528_RS11815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BM528_RS11830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BM528_RS11835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BM528_RS11835	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BM528_RS11910	COG0789	Transcriptional regulator
BM528_RS11915	COG4977	sequence-specific DNA binding
BM528_RS11940	COG2132	Multicopper oxidase
BM528_RS11945	COG3667	copper resistance
BM528_RS12085	COG3101	peptidyl-lysine hydroxylation
BM528_RS12105	COG1620	l-lactate permease
BM528_RS12115	COG0352	thiamine-phosphate diphosphorylase activity
BM528_RS12135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BM528_RS12140	COG0446	pyridine nucleotide-disulphide oxidoreductase
BM528_RS12140	COG1902	pentaerythritol trinitrate reductase activity
BM528_RS12145	COG1024	Enoyl-CoA hydratase
BM528_RS12165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BM528_RS12175	COG4399	Belongs to the UPF0754 family
BM528_RS12200	COG2186	Transcriptional regulator
BM528_RS12210	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BM528_RS12215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BM528_RS12220	COG2983	Belongs to the UPF0260 family
BM528_RS12225	COG0179	Fumarylacetoacetate (FAA) hydrolase
BM528_RS12240	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BM528_RS12245	COG0318	PFAM AMP-dependent synthetase and ligase
BM528_RS12260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BM528_RS12265	COG1607	acyl-coa hydrolase
BM528_RS12300	COG1183	phosphatidylcholine synthase activity
BM528_RS12320	COG0277	FAD linked oxidase domain protein
BM528_RS12330	COG0542	response to heat
BM528_RS12340	COG0564	pseudouridine synthase activity
BM528_RS12355	COG1595	DNA-templated transcription, initiation
BM528_RS12370	COG4221	oxidoreductase activity
BM528_RS12375	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BM528_RS12385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BM528_RS12395	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BM528_RS12405	COG0142	geranyltranstransferase activity
BM528_RS12415	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BM528_RS12420	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BM528_RS12430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BM528_RS12445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BM528_RS12445	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BM528_RS12460	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BM528_RS12465	COG0488	(ABC) transporter
BM528_RS12475	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BM528_RS12485	COG0560	Phosphoserine phosphatase
BM528_RS12495	COG0084	hydrolase, TatD family'
BM528_RS12530	COG3026	antisigma factor binding
BM528_RS12540	COG1595	DNA-templated transcription, initiation
BM528_RS12545	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BM528_RS12555	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BM528_RS12595	COG4795	General secretion pathway protein
BM528_RS12635	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BM528_RS12640	COG1047	Peptidyl-prolyl cis-trans
BM528_RS12650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BM528_RS12655	COG0196	riboflavin kinase activity
BM528_RS12660	COG0728	peptidoglycan biosynthetic process
BM528_RS12665	COG0268	Binds directly to 16S ribosomal RNA
BM528_RS12690	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BM528_RS12700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM528_RS12705	COG0776	regulation of translation
BM528_RS12710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BM528_RS12715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BM528_RS12720	COG0740	serine-type endopeptidase activity
BM528_RS12725	COG0544	peptidyl-prolyl cis-trans isomerase activity
BM528_RS12770	COG1720	tRNA m6t6A37 methyltransferase activity
BM528_RS12780	COG1234	tRNA 3'-trailer cleavage
BM528_RS12790	COG0123	including yeast histone deacetylase and acetoin utilization protein
BM528_RS12815	COG0516	GMP reductase activity
BM528_RS12815	COG0517	IMP dehydrogenase activity
BM528_RS12820	COG1570	exodeoxyribonuclease VII activity
BM528_RS12845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BM528_RS12855	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM528_RS12860	COG2976	Protein conserved in bacteria
BM528_RS12880	COG3063	Type IV pilus biogenesis stability protein PilW
BM528_RS12885	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BM528_RS12895	COG2166	iron-sulfur cluster assembly
BM528_RS12905	COG0316	Belongs to the HesB IscA family
BM528_RS12910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BM528_RS12915	COG0719	Fe-S assembly protein
BM528_RS12920	COG0396	ATPase activity
BM528_RS12925	COG0719	Fe-S assembly protein
BM528_RS12930	COG1104	cysteine desulfurase activity
BM528_RS12935	COG1959	2 iron, 2 sulfur cluster binding
BM528_RS12955	COG2072	flavoprotein involved in K transport
BM528_RS12965	COG1045	serine acetyltransferase
BM528_RS12970	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BM528_RS12975	COG0483	inositol monophosphate 1-phosphatase activity
BM528_RS12985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM528_RS12990	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM528_RS12995	COG1862	Preprotein translocase
BM528_RS13000	COG0343	queuine tRNA-ribosyltransferase activity
BM528_RS13020	COG1842	Phage shock protein A
BM528_RS13025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BM528_RS13045	COG0754	glutathionylspermidine amidase activity
BM528_RS13060	COG1136	(ABC) transporter
BM528_RS13075	COG2066	Belongs to the glutaminase family
BM528_RS13080	COG1785	Belongs to the alkaline phosphatase family
BM528_RS13085	COG0745	RESPONSE REGULATOR receiver
BM528_RS13095	COG0784	Response regulator, receiver
BM528_RS13095	COG0835	chemotaxis
BM528_RS13205	COG0438	transferase activity, transferring glycosyl groups
BM528_RS13220	COG0367	asparagine synthase
BM528_RS13225	COG0438	transferase activity, transferring glycosyl groups
BM528_RS13255	COG2244	polysaccharide biosynthetic process
BM528_RS13315	COG0489	protein tyrosine kinase activity
BM528_RS13325	COG3267	Type II secretory pathway component ExeA
BM528_RS13325	COG3409	Peptidoglycan-binding domain 1 protein
BM528_RS13330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BM528_RS13330	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BM528_RS13355	COG1560	Kdo2-lipid A biosynthetic process
BM528_RS13385	COG1960	acyl-CoA dehydrogenase activity
BM528_RS13405	COG1435	thymidine kinase activity
BM528_RS13410	COG1609	Transcriptional regulator
BM528_RS13415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BM528_RS13430	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BM528_RS13435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM528_RS13455	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
BM528_RS13490	COG1960	acyl-CoA dehydrogenase activity
BM528_RS13535	COG4221	oxidoreductase activity
BM528_RS13540	COG1280	lysine exporter protein (LysE YggA)
BM528_RS13570	COG1028	Short-chain dehydrogenase reductase Sdr
BM528_RS13630	COG4771	TonB-dependent receptor
BM528_RS13630	COG1629	transport
BM528_RS13635	COG4558	Periplasmic binding protein
BM528_RS13640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BM528_RS13645	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BM528_RS13680	COG0514	ATP-dependent DNA helicase (RecQ)
BM528_RS13685	COG1295	ribonuclease BN
BM528_RS13695	COG1476	TRANSCRIPTIONal
BM528_RS13705	COG2205	protein histidine kinase activity
BM528_RS13705	COG4999	Histidine kinase
BM528_RS13705	COG3850	Histidine kinase
BM528_RS13705	COG3437	response regulator, receiver
BM528_RS13735	COG2133	pyrroloquinoline quinone binding
BM528_RS13740	COG0513	Belongs to the DEAD box helicase family
BM528_RS13760	COG3177	Filamentation induced by cAMP protein fic
BM528_RS13765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BM528_RS13770	COG1518	maintenance of DNA repeat elements
BM528_RS13805	COG1203	CRISPR-associated helicase, Cas3
BM528_RS13875	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BM528_RS13895	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BM528_RS13895	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BM528_RS13915	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BM528_RS13920	COG0583	DNA-binding transcription factor activity
BM528_RS13930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM528_RS13935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM528_RS13940	COG0006	proline dipeptidase activity
BM528_RS13945	COG3079	Belongs to the UPF0149 family
BM528_RS13955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM528_RS13965	COG5002	protein histidine kinase activity
BM528_RS13965	COG0784	Response regulator, receiver
BM528_RS13970	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BM528_RS13975	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BM528_RS13980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BM528_RS14035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM528_RS14040	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM528_RS14045	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BM528_RS14060	COG3023	N-Acetylmuramoyl-L-alanine amidase
BM528_RS14065	COG0675	Transposase, IS605 OrfB family
BM528_RS14075	COG3577	Aspartyl protease
BM528_RS14080	COG0157	Belongs to the NadC ModD family
BM528_RS14090	COG1459	type II secretion system
BM528_RS14100	COG0237	dephospho-CoA kinase activity
BM528_RS14105	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BM528_RS14110	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BM528_RS14115	COG3608	succinylglutamate desuccinylase aspartoacylase
BM528_RS14120	COG0494	nUDIX hydrolase
BM528_RS14130	COG0739	heme binding
BM528_RS14135	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BM528_RS14140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BM528_RS14145	COG0849	cell division
BM528_RS14150	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BM528_RS14155	COG1181	Belongs to the D-alanine--D-alanine ligase family
BM528_RS14170	COG0772	Belongs to the SEDS family
BM528_RS14175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BM528_RS14185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BM528_RS14190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BM528_RS14195	COG0768	penicillin binding
BM528_RS14200	COG3116	cell division
BM528_RS14210	COG2001	Belongs to the MraZ family
BM528_RS14230	COG0678	peroxiredoxin activity
BM528_RS14230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BM528_RS14260	COG2204	response regulator
BM528_RS14265	COG5002	protein histidine kinase activity
BM528_RS14290	COG0668	transmembrane transport
BM528_RS14300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BM528_RS14305	COG0189	ligase activity
BM528_RS14310	COG1678	Uncharacterized ACR, COG1678
BM528_RS14315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BM528_RS14335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BM528_RS14340	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BM528_RS14345	COG0762	integral membrane protein
BM528_RS14355	COG0446	pyridine nucleotide-disulphide oxidoreductase
BM528_RS14355	COG1902	pentaerythritol trinitrate reductase activity
BM528_RS14405	COG0083	homoserine kinase activity
BM528_RS14415	COG0583	DNA-binding transcription factor activity
BM528_RS14430	COG0640	Transcriptional regulator
BM528_RS14440	COG0431	NADPH-dependent FMN reductase
BM528_RS14445	COG0798	PFAM Bile acid sodium symporter
BM528_RS14455	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BM528_RS14460	COG0745	RESPONSE REGULATOR receiver
BM528_RS14490	COG1748	Saccharopine dehydrogenase
BM528_RS14505	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BM528_RS14510	COG3107	peptidoglycan biosynthetic process
BM528_RS14515	COG0792	nuclease activity
BM528_RS14525	COG2823	Periplasmic or secreted lipoprotein
BM528_RS14535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BM528_RS14550	COG2212	antiporter activity
BM528_RS14555	COG1863	multisubunit Na H antiporter MnhE subunit
BM528_RS14560	COG0651	ATP synthesis coupled electron transport
BM528_RS14565	COG1006	Multisubunit Na H antiporter MnhC subunit
BM528_RS14570	COG2111	Na H antiporter
BM528_RS14570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BM528_RS14585	COG4771	TonB-dependent receptor
BM528_RS14595	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BM528_RS14600	COG0372	Belongs to the citrate synthase family
BM528_RS14605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BM528_RS14610	COG2828	Protein conserved in bacteria
BM528_RS14615	COG2203	Gaf domain
BM528_RS14615	COG2199	diguanylate cyclase activity
BM528_RS14635	COG0784	Response regulator, receiver
BM528_RS14635	COG5002	protein histidine kinase activity
BM528_RS14635	COG2198	Histidine kinase
BM528_RS14645	COG0069	glutamate synthase activity
BM528_RS14645	COG0070	glutamate synthase
BM528_RS14645	COG0067	glutamate synthase
BM528_RS14650	COG0493	'glutamate synthase
BM528_RS14660	COG0154	amidase activity
BM528_RS14670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BM528_RS14680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BM528_RS14685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM528_RS14700	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BM528_RS14705	COG0739	heme binding
BM528_RS14710	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BM528_RS14720	COG4572	Cation transport regulator
BM528_RS14725	COG4555	ABC transporter
BM528_RS14745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BM528_RS14750	COG0625	glutathione transferase activity
BM528_RS14760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM528_RS14760	COG4191	Histidine kinase
BM528_RS14765	COG2203	Gaf domain
BM528_RS14765	COG4251	negative regulation of phosphorylation
BM528_RS14765	COG5001	Diguanylate cyclase
BM528_RS14765	COG3706	GGDEF domain
BM528_RS14775	COG2894	cell division
BM528_RS14780	COG0850	regulation of cytokinetic process
BM528_RS14805	COG1981	membrane
BM528_RS14820	COG1914	H( )-stimulated, divalent metal cation uptake system
BM528_RS14825	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BM528_RS14835	COG1217	gtp-binding protein TYPA
BM528_RS14840	COG0174	glutamine synthetase
BM528_RS14850	COG3852	Histidine kinase
BM528_RS14855	COG2204	response regulator
BM528_RS14860	COG3437	response regulator, receiver
BM528_RS14890	COG0525	valine-tRNA ligase activity
BM528_RS14895	COG2927	DNA polymerase III (CHI subunit)
BM528_RS14900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BM528_RS14905	COG0795	lipopolysaccharide-transporting ATPase activity
BM528_RS14910	COG0795	lipopolysaccharide-transporting ATPase activity
BM528_RS14955	COG0738	Major facilitator superfamily
BM528_RS14975	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BM528_RS14985	COG0464	growth
BM528_RS14990	COG1404	Belongs to the peptidase S8 family
BM528_RS15000	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BM528_RS15005	COG0732	type I restriction modification DNA specificity domain
BM528_RS15010	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BM528_RS15085	COG0450	alkyl hydroperoxide reductase
BM528_RS15095	COG0425	Belongs to the sulfur carrier protein TusA family
BM528_RS15095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM528_RS15130	COG3268	Saccharopine dehydrogenase
BM528_RS15135	COG1960	acyl-CoA dehydrogenase activity
BM528_RS15165	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BM528_RS15170	COG3706	GGDEF domain
BM528_RS15205	COG0277	FAD linked oxidase domain protein
BM528_RS15215	COG0513	Belongs to the DEAD box helicase family
BM528_RS15220	COG5001	Diguanylate cyclase
BM528_RS15235	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BM528_RS15235	COG3264	Mechanosensitive ion channel
BM528_RS15250	COG2199	diguanylate cyclase activity
BM528_RS15250	COG2202	Pas domain
BM528_RS15250	COG2200	EAL domain
BM528_RS15265	COG0583	DNA-binding transcription factor activity
BM528_RS15270	COG0730	response to heat
BM528_RS15275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM528_RS15280	COG0745	RESPONSE REGULATOR receiver
BM528_RS15290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM528_RS15290	COG4191	Histidine kinase
BM528_RS15350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM528_RS15360	COG1573	uracil-dna glycosylase
BM528_RS15365	COG3300	MHYT domain
BM528_RS15365	COG5001	Diguanylate cyclase
BM528_RS15385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BM528_RS15410	COG1842	Phage shock protein A
BM528_RS15420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM528_RS15430	COG3550	peptidyl-serine autophosphorylation
BM528_RS15450	COG0204	Acyl-transferase
BM528_RS15455	COG0204	Acyl-transferase
BM528_RS15460	COG0668	transmembrane transport
BM528_RS15475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM528_RS15480	COG0733	neurotransmitter:sodium symporter activity
BM528_RS15495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM528_RS15510	COG0716	FMN binding
BM528_RS15520	COG0848	biopolymer transport protein
BM528_RS15530	COG0457	Tetratricopeptide repeat
BM528_RS15535	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BM528_RS15560	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BM528_RS15580	COG5002	protein histidine kinase activity
BM528_RS15580	COG5001	Diguanylate cyclase
BM528_RS15590	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BM528_RS15600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM528_RS15610	COG0583	DNA-binding transcription factor activity
BM528_RS15615	COG0121	glutamine amidotransferase
BM528_RS15620	COG4628	conserved protein (DUF2132)
BM528_RS15645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM528_RS15655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BM528_RS15665	COG1477	protein flavinylation
BM528_RS15670	COG2871	sodium ion transport
BM528_RS15675	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM528_RS15680	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM528_RS15685	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM528_RS15690	COG1805	sodium ion transport
BM528_RS15695	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM528_RS15700	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BM528_RS15705	COG0545	Peptidyl-prolyl cis-trans isomerase
BM528_RS15710	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BM528_RS15720	COG0039	L-malate dehydrogenase activity
BM528_RS15725	COG1438	arginine binding
BM528_RS15750	COG0572	uridine kinase
BM528_RS15755	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BM528_RS15770	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BM528_RS15785	COG0517	IMP dehydrogenase activity
BM528_RS15785	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BM528_RS15790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM528_RS15800	COG5002	protein histidine kinase activity
BM528_RS15810	COG0189	ligase activity
BM528_RS15820	COG4067	protein conserved in archaea
BM528_RS15820	COG0189	ligase activity
BM528_RS15835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BM528_RS15845	COG1283	sodium-dependent phosphate transmembrane transporter activity
BM528_RS15850	COG0667	Aldo Keto reductase
BM528_RS15860	COG5001	Diguanylate cyclase
BM528_RS15960	COG1484	DNA-dependent DNA replication
BM528_RS15965	COG4584	PFAM Integrase catalytic
BM528_RS15975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BM528_RS16000	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BM528_RS16010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BM528_RS16055	COG0583	DNA-binding transcription factor activity
BM528_RS16070	COG2963	transposase activity
BM528_RS16075	COG2963	transposase activity
BM528_RS16090	COG1215	transferase activity, transferring glycosyl groups
BM528_RS16135	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BM528_RS16135	COG0662	Cupin 2, conserved barrel domain protein
BM528_RS16160	COG3706	GGDEF domain
BM528_RS16170	COG0202	RNA polymerase activity
BM528_RS16190	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BM528_RS16195	COG0201	protein transport
BM528_RS16200	COG0200	Binds to the 23S rRNA
BM528_RS16260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM528_RS16265	COG0557	exoribonuclease II activity
BM528_RS16285	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BM528_RS16305	COG2234	aminopeptidase activity
BM528_RS16315	COG4251	negative regulation of phosphorylation
BM528_RS16330	COG1271	oxidase subunit
BM528_RS16335	COG1294	oxidase, subunit
BM528_RS16340	COG1522	sequence-specific DNA binding
BM528_RS16350	COG1278	Cold shock
BM528_RS16355	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM528_RS16375	COG0339	signal peptide processing
BM528_RS16380	COG2201	protein-glutamate methylesterase activity
BM528_RS16390	COG4191	Histidine kinase
BM528_RS16390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM528_RS16400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM528_RS16410	COG0823	Involved in the tonB-independent uptake of proteins
BM528_RS16410	COG1506	peptidase
BM528_RS16410	COG4946	Tricorn protease homolog
BM528_RS16465	COG2197	response regulator
BM528_RS16475	COG0189	ligase activity
BM528_RS16485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BM528_RS16490	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BM528_RS16495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BM528_RS16510	COG0281	malic enzyme
BM528_RS16520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BM528_RS16550	COG0456	acetyltransferase
BM528_RS16560	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BM528_RS16565	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BM528_RS16570	COG2177	Part of the ABC transporter FtsEX involved in
BM528_RS16575	COG2884	Cell division ATP-binding protein ftsE
BM528_RS16580	COG0552	protein localization to endoplasmic reticulum
BM528_RS16585	COG0742	ribosomal rna small subunit methyltransferase
BM528_RS16590	COG3068	Protein conserved in bacteria
BM528_RS16595	COG2095	MarC family integral membrane protein
BM528_RS16615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BM528_RS16620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM528_RS16630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BM528_RS16645	COG0076	glutamate decarboxylase activity
BM528_RS16660	COG0842	Transport permease protein
BM528_RS16665	COG1131	(ABC) transporter
BM528_RS16670	COG4774	siderophore transport
BM528_RS16680	COG1253	flavin adenine dinucleotide binding
BM528_RS16690	COG1966	Carbon starvation protein
BM528_RS16720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BM528_RS16725	COG0049	tRNA binding
BM528_RS16730	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BM528_RS16735	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BM528_RS16740	COG0085	RNA polymerase activity
BM528_RS16745	COG0222	ribosome binding
BM528_RS16750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BM528_RS16755	COG0081	regulation of translation
BM528_RS16760	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BM528_RS16765	COG3706	GGDEF domain
BM528_RS16775	COG0250	Participates in transcription elongation, termination and antitermination
BM528_RS16780	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BM528_RS16790	COG1132	(ABC) transporter
BM528_RS16805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BM528_RS16810	COG3590	peptidase
BM528_RS16820	COG0513	Belongs to the DEAD box helicase family
BM528_RS16825	COG0418	dihydroorotase activity
BM528_RS16835	COG3040	lipid binding
BM528_RS16840	COG4989	oxidoreductase activity
BM528_RS16845	COG0346	lactoylglutathione lyase activity
BM528_RS16865	COG0302	gtp cyclohydrolase
BM528_RS16875	COG2957	Belongs to the agmatine deiminase family
BM528_RS16880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM528_RS16890	COG1201	RNA secondary structure unwinding
BM528_RS16910	COG1793	dna ligase
BM528_RS16930	COG0625	glutathione transferase activity
BM528_RS16940	COG5380	lipid catabolic process
BM528_RS16945	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BM528_RS16960	COG1012	belongs to the aldehyde dehydrogenase family
BM528_RS16965	COG0028	Belongs to the TPP enzyme family
BM528_RS16975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BM528_RS16980	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BM528_RS16985	COG0330	HflC and HflK could
BM528_RS16990	COG0330	HflC and HflK could
BM528_RS16995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BM528_RS17000	COG1923	regulation of RNA biosynthetic process
BM528_RS17005	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BM528_RS17020	COG0802	atpase or kinase
BM528_RS17025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BM528_RS17025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BM528_RS17045	COG2816	NAD+ diphosphatase activity
BM528_RS17050	COG0735	belongs to the Fur family
BM528_RS17060	COG0432	Pfam Uncharacterised protein family UPF0047
BM528_RS17070	COG0305	Participates in initiation and elongation during chromosome replication
BM528_RS17095	COG2258	MOSC domain
BM528_RS17120	COG5002	protein histidine kinase activity
BM528_RS17130	COG1136	(ABC) transporter
BM528_RS17140	COG0840	transmembrane signaling receptor activity
BM528_RS17145	COG5002	protein histidine kinase activity
BM528_RS17175	COG4774	siderophore transport
BM528_RS17180	COG1472	Belongs to the glycosyl hydrolase 3 family
BM528_RS17190	COG2723	6-phospho-beta-galactosidase activity
BM528_RS17195	COG1609	Transcriptional regulator
BM528_RS17200	COG2814	Major facilitator Superfamily
BM528_RS17200	COG0477	Major facilitator Superfamily
BM528_RS17205	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BM528_RS17210	COG4988	ABC transporter
BM528_RS17215	COG4890	Cyd operon protein YbgT
BM528_RS17220	COG1294	oxidase, subunit
BM528_RS17235	COG2204	response regulator
BM528_RS17250	COG2375	cellular response to nickel ion
BM528_RS17270	COG2267	carboxylic ester hydrolase activity
BM528_RS17280	COG3038	cytochrome b561
BM528_RS17285	COG2353	YceI-like domain
BM528_RS17290	COG1252	NADH dehydrogenase
BM528_RS17310	COG2067	long-chain fatty acid transport protein
BM528_RS17315	COG5001	Diguanylate cyclase
BM528_RS17315	COG2203	Gaf domain
BM528_RS17315	COG3706	GGDEF domain
BM528_RS17315	COG4251	negative regulation of phosphorylation
BM528_RS17330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BM528_RS17340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BM528_RS17350	COG0673	inositol 2-dehydrogenase activity
BM528_RS17365	COG0697	spore germination
BM528_RS17370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BM528_RS17375	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BM528_RS17385	COG1166	arginine decarboxylase activity
BM528_RS17395	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BM528_RS17415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM528_RS17440	COG4232	protein-disulfide reductase activity
BM528_RS17450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BM528_RS17455	COG0511	ligase activity, forming carbon-carbon bonds
BM528_RS17460	COG0439	Biotin carboxylase
BM528_RS17475	COG2176	DNA-directed DNA polymerase activity
BM528_RS17515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM528_RS17520	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BM528_RS17540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM528_RS17560	COG3093	addiction module antidote protein HigA
BM528_RS17595	COG3954	Phosphoribulokinase
BM528_RS17615	COG1501	Belongs to the glycosyl hydrolase 31 family
BM528_RS17620	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BM528_RS17625	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BM528_RS17635	COG3031	protein transport across the cell outer membrane
BM528_RS17645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BM528_RS17650	COG1459	type II secretion system
BM528_RS17655	COG2165	general secretion pathway protein
BM528_RS17660	COG2165	general secretion pathway protein
BM528_RS17665	COG2165	general secretion pathway protein
BM528_RS17670	COG4795	General secretion pathway protein
BM528_RS17675	COG3156	type II secretion system protein K
BM528_RS17685	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
BM528_RS17705	COG1012	belongs to the aldehyde dehydrogenase family
BM528_RS17715	COG1011	Hydrolase
BM528_RS17720	COG0494	nUDIX hydrolase
BM528_RS17725	COG1218	3'(2'),5'-bisphosphate nucleotidase
BM528_RS17735	COG2943	transferase activity, transferring hexosyl groups
BM528_RS17740	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BM528_RS17750	COG3089	Belongs to the UPF0270 family
BM528_RS17755	COG0429	hydrolase of the alpha beta-hydrolase fold
BM528_RS17765	COG0488	(ABC) transporter
BM528_RS17775	COG2900	Belongs to the SlyX family
BM528_RS17785	COG0545	Peptidyl-prolyl cis-trans isomerase
BM528_RS17800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BM528_RS17805	COG2183	response to ionizing radiation
BM528_RS17820	COG0596	Alpha beta hydrolase
BM528_RS17825	COG1040	competence protein
BM528_RS17845	COG1794	racemase activity, acting on amino acids and derivatives
BM528_RS17855	COG0534	Mate efflux family protein
BM528_RS17870	COG1999	signal sequence binding
BM528_RS17875	COG0109	protoheme IX farnesyltransferase activity
BM528_RS17880	COG1612	heme a metabolic process
BM528_RS17910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BM528_RS17915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BM528_RS17945	COG0129	dihydroxy-acid dehydratase activity
BM528_RS17950	COG2860	membrane
BM528_RS17955	COG0606	chelatase, subunit chli
BM528_RS17970	COG2814	Major facilitator Superfamily
BM528_RS17980	COG0729	surface antigen
BM528_RS17985	COG2911	Protein conserved in bacteria
BM528_RS17995	COG1595	DNA-templated transcription, initiation
BM528_RS18010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BM528_RS18020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BM528_RS18040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM528_RS18065	COG1228	amidohydrolase
BM528_RS18080	COG0425	Belongs to the sulfur carrier protein TusA family
BM528_RS18095	COG1561	YicC-like family, N-terminal region
BM528_RS18205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BM528_RS18225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BM528_RS18230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BM528_RS18250	COG1475	DNA binding
BM528_RS18255	COG1192	Involved in chromosome partitioning
BM528_RS18280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BM528_RS18285	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BM528_RS18295	COG0706	membrane insertase activity
BM528_RS18300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BM528_RS18305	COG0594	ribonuclease P activity
BM528_RS18310	COG0230	Belongs to the bacterial ribosomal protein bL34 family