locus-tag	class	description
AVL57_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AVL57_RS00020	COG0187	DNA topoisomerase II activity
AVL57_RS00045	COG2818	Glycosylase
AVL57_RS00055	COG3078	GTPase activator activity
AVL57_RS00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AVL57_RS00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AVL57_RS00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AVL57_RS00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AVL57_RS00085	COG0569	domain protein
AVL57_RS00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AVL57_RS00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AVL57_RS00110	COG0758	DNA mediated transformation
AVL57_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
AVL57_RS00130	COG0408	coproporphyrinogen oxidase activity
AVL57_RS00135	COG3047	cAMP biosynthetic process
AVL57_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AVL57_RS00205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AVL57_RS00225	COG2234	aminopeptidase activity
AVL57_RS00240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AVL57_RS00265	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVL57_RS00305	COG3642	lipopolysaccharide core region biosynthetic process
AVL57_RS00310	COG0859	PFAM glycosyl transferase family 9
AVL57_RS00330	COG0156	8-amino-7-oxononanoate synthase activity
AVL57_RS00340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVL57_RS00345	COG0705	Rhomboid family
AVL57_RS00355	COG3161	chorismate lyase activity
AVL57_RS00360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AVL57_RS00365	COG2960	long-chain fatty acid transporting porin activity
AVL57_RS00370	COG0210	DNA helicase
AVL57_RS00390	COG0653	protein targeting
AVL57_RS00400	COG1757	Na H antiporter
AVL57_RS00420	COG0326	Molecular chaperone. Has ATPase activity
AVL57_RS00430	COG0556	nucleotide-excision repair
AVL57_RS00435	COG1620	l-lactate permease
AVL57_RS00445	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AVL57_RS00450	COG2181	nitrate reductase activity
AVL57_RS00450	COG0247	lactate metabolic process
AVL57_RS00455	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVL57_RS00455	COG1902	pentaerythritol trinitrate reductase activity
AVL57_RS00475	COG4638	Rieske (2fe-2S)
AVL57_RS00490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AVL57_RS00530	COG1760	l-serine dehydratase
AVL57_RS00535	COG0583	DNA-binding transcription factor activity
AVL57_RS00550	COG1012	belongs to the aldehyde dehydrogenase family
AVL57_RS00555	COG4948	Mandelate Racemase Muconate Lactonizing
AVL57_RS00565	COG1012	belongs to the aldehyde dehydrogenase family
AVL57_RS00570	COG4771	TonB-dependent receptor
AVL57_RS00575	COG0457	Tetratricopeptide repeat
AVL57_RS00580	COG2205	protein histidine kinase activity
AVL57_RS00580	COG3437	response regulator, receiver
AVL57_RS00580	COG4999	Histidine kinase
AVL57_RS00580	COG3850	Histidine kinase
AVL57_RS00585	COG4773	Receptor
AVL57_RS00590	COG0583	DNA-binding transcription factor activity
AVL57_RS00605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVL57_RS00610	COG1129	ABC transporter
AVL57_RS00610	COG0842	Transport permease protein
AVL57_RS00615	COG0842	Transport permease protein
AVL57_RS00625	COG1960	acyl-CoA dehydrogenase activity
AVL57_RS00630	COG0583	DNA-binding transcription factor activity
AVL57_RS00645	COG3106	COG3106 Predicted ATPase
AVL57_RS00665	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AVL57_RS00680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AVL57_RS00695	COG4771	TonB-dependent receptor
AVL57_RS00700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL57_RS00710	COG0778	Nitroreductase
AVL57_RS00710	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AVL57_RS00720	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AVL57_RS00725	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AVL57_RS00730	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AVL57_RS00735	COG1309	transcriptional regulator
AVL57_RS00760	COG1953	Uracil, thiamine, allantoin
AVL57_RS00770	COG3071	HemY protein
AVL57_RS00775	COG2959	enzyme of heme biosynthesis
AVL57_RS00785	COG0181	hydroxymethylbilane synthase activity
AVL57_RS00800	COG0194	GDP metabolic process
AVL57_RS00810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AVL57_RS00820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVL57_RS00825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AVL57_RS00835	COG0678	peroxiredoxin activity
AVL57_RS00835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AVL57_RS00855	COG1178	ABC-type Fe3 transport system permease component
AVL57_RS00860	COG3842	ATPase activity
AVL57_RS00865	COG2081	HI0933 family
AVL57_RS00870	COG0668	transmembrane transport
AVL57_RS00895	COG5002	protein histidine kinase activity
AVL57_RS00895	COG3447	MASE1 domain protein
AVL57_RS00895	COG5001	Diguanylate cyclase
AVL57_RS00905	COG0583	DNA-binding transcription factor activity
AVL57_RS00930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVL57_RS00935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVL57_RS00945	COG0427	acetyl-CoA hydrolase
AVL57_RS00950	COG0123	including yeast histone deacetylase and acetoin utilization protein
AVL57_RS00960	COG0840	transmembrane signaling receptor activity
AVL57_RS00970	COG3064	Membrane
AVL57_RS00975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVL57_RS00980	COG5002	protein histidine kinase activity
AVL57_RS00980	COG5001	Diguanylate cyclase
AVL57_RS00990	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AVL57_RS01000	COG0514	ATP-dependent DNA helicase (RecQ)
AVL57_RS01005	COG2050	protein possibly involved in aromatic compounds catabolism
AVL57_RS01010	COG2239	Acts as a magnesium transporter
AVL57_RS01015	COG2962	Rard protein
AVL57_RS01035	COG1011	Hydrolase
AVL57_RS01050	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AVL57_RS01055	COG0019	diaminopimelate decarboxylase activity
AVL57_RS01085	COG0163	prenyltransferase activity
AVL57_RS01090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AVL57_RS01100	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AVL57_RS01125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AVL57_RS01130	COG2814	Major facilitator Superfamily
AVL57_RS01135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVL57_RS01155	COG1085	galactose-1-phosphate uridylyltransferase
AVL57_RS01160	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AVL57_RS01170	COG0629	single-stranded DNA binding
AVL57_RS01210	COG3710	Transcriptional regulator
AVL57_RS01220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL57_RS01240	COG4615	Cyclic peptide transporter
AVL57_RS01255	COG0745	RESPONSE REGULATOR receiver
AVL57_RS01265	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AVL57_RS01295	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVL57_RS01320	COG1349	DNA-binding transcription factor activity
AVL57_RS01360	COG3409	Peptidoglycan-binding domain 1 protein
AVL57_RS01360	COG3267	Type II secretory pathway component ExeA
AVL57_RS01370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AVL57_RS01375	COG1459	type II secretion system
AVL57_RS01385	COG2165	general secretion pathway protein
AVL57_RS01390	COG2165	general secretion pathway protein
AVL57_RS01415	COG1077	Cell shape determining protein MreB Mrl
AVL57_RS01420	COG1792	Involved in formation and maintenance of cell shape
AVL57_RS01425	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AVL57_RS01435	COG1530	ribonuclease E activity
AVL57_RS01445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVL57_RS01450	COG0312	modulator of DNA gyrase
AVL57_RS01460	COG3028	Belongs to the UPF0307 family
AVL57_RS01465	COG0312	modulator of DNA gyrase
AVL57_RS01480	COG0745	RESPONSE REGULATOR receiver
AVL57_RS01485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVL57_RS01485	COG4191	Histidine kinase
AVL57_RS01490	COG0297	glycogen (starch) synthase activity
AVL57_RS01500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AVL57_RS01510	COG1194	a g-specific adenine glycosylase
AVL57_RS01565	COG0745	RESPONSE REGULATOR receiver
AVL57_RS01570	COG2198	Histidine kinase
AVL57_RS01570	COG0643	Histidine kinase
AVL57_RS01575	COG0835	chemotaxis
AVL57_RS01590	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AVL57_RS01595	COG2201	protein-glutamate methylesterase activity
AVL57_RS01610	COG0501	Belongs to the peptidase M48B family
AVL57_RS01670	COG1609	Transcriptional regulator
AVL57_RS01675	COG0673	inositol 2-dehydrogenase activity
AVL57_RS01685	COG2211	Major facilitator Superfamily
AVL57_RS01735	COG1454	alcohol dehydrogenase
AVL57_RS01755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AVL57_RS01760	COG0051	transcription antitermination factor activity, RNA binding
AVL57_RS01775	COG0089	rRNA binding
AVL57_RS01785	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AVL57_RS01795	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AVL57_RS01810	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AVL57_RS01815	COG0438	transferase activity, transferring glycosyl groups
AVL57_RS01820	COG0859	PFAM glycosyl transferase family 9
AVL57_RS01825	COG1519	Transferase
AVL57_RS01860	COG0788	formyltetrahydrofolate deformylase activity
AVL57_RS01870	COG1643	Atp-dependent helicase
AVL57_RS01875	COG2951	lytic endotransglycosylase activity
AVL57_RS01885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AVL57_RS01895	COG2354	Protein conserved in bacteria
AVL57_RS01920	COG0004	ammonium transporteR
AVL57_RS01925	COG0405	Gamma-glutamyltransferase
AVL57_RS01930	COG2837	iron assimilation
AVL57_RS01945	COG0540	Belongs to the ATCase OTCase family
AVL57_RS01970	COG0784	Response regulator, receiver
AVL57_RS01970	COG5002	protein histidine kinase activity
AVL57_RS01970	COG2205	protein histidine kinase activity
AVL57_RS01995	COG1012	belongs to the aldehyde dehydrogenase family
AVL57_RS02005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVL57_RS02015	COG0512	Glutamine amidotransferase of anthranilate synthase
AVL57_RS02020	COG0180	Tryptophanyl-tRNA synthetase
AVL57_RS02025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AVL57_RS02045	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AVL57_RS02055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AVL57_RS02090	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AVL57_RS02095	COG0281	malic enzyme
AVL57_RS02100	COG0625	glutathione transferase activity
AVL57_RS02135	COG5001	Diguanylate cyclase
AVL57_RS02135	COG3300	MHYT domain
AVL57_RS02140	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AVL57_RS02140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AVL57_RS02150	COG0137	argininosuccinate synthase activity
AVL57_RS02155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AVL57_RS02170	COG1803	Methylglyoxal synthase
AVL57_RS02180	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AVL57_RS02195	COG0745	RESPONSE REGULATOR receiver
AVL57_RS02200	COG2205	protein histidine kinase activity
AVL57_RS02205	COG2267	carboxylic ester hydrolase activity
AVL57_RS02210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AVL57_RS02225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AVL57_RS02235	COG4942	peptidase
AVL57_RS02245	COG2861	carbohydrate metabolic process
AVL57_RS02255	COG0584	glycerophosphoryl diester phosphodiesterase
AVL57_RS02270	COG1162	GTPase activity
AVL57_RS02275	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AVL57_RS02295	COG0457	Tetratricopeptide repeat
AVL57_RS02310	COG0028	Belongs to the TPP enzyme family
AVL57_RS02330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVL57_RS02335	COG0805	protein transport
AVL57_RS02360	COG0248	Ppx GppA phosphatase
AVL57_RS02365	COG0513	Belongs to the DEAD box helicase family
AVL57_RS02370	COG3118	belongs to the thioredoxin family
AVL57_RS02375	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AVL57_RS02380	COG1473	amidohydrolase
AVL57_RS02385	COG0784	Response regulator, receiver
AVL57_RS02385	COG2205	protein histidine kinase activity
AVL57_RS02390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AVL57_RS02395	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AVL57_RS02400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AVL57_RS02415	COG0783	Belongs to the Dps family
AVL57_RS02420	COG2133	pyrroloquinoline quinone binding
AVL57_RS02430	COG3118	belongs to the thioredoxin family
AVL57_RS02440	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AVL57_RS02450	COG1012	belongs to the aldehyde dehydrogenase family
AVL57_RS02470	COG1757	Na H antiporter
AVL57_RS02490	COG3876	Protein conserved in bacteria
AVL57_RS02495	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AVL57_RS02515	COG0346	lactoylglutathione lyase activity
AVL57_RS02580	COG4115	mRNA cleavage
AVL57_RS02585	COG2161	toxin-antitoxin pair type II binding
AVL57_RS02700	COG0183	Belongs to the thiolase family
AVL57_RS02705	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVL57_RS02705	COG1024	Enoyl-CoA hydratase
AVL57_RS02715	COG0006	proline dipeptidase activity
AVL57_RS02725	COG0142	geranyltranstransferase activity
AVL57_RS02785	COG1238	metal cluster binding
AVL57_RS02795	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AVL57_RS02800	COG0585	pseudouridine synthase activity
AVL57_RS02815	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AVL57_RS02825	COG0840	transmembrane signaling receptor activity
AVL57_RS02830	COG0506	proline dehydrogenase activity
AVL57_RS02830	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AVL57_RS02830	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AVL57_RS02845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVL57_RS02860	COG4991	sh3 domain protein
AVL57_RS02865	COG3025	triphosphatase activity
AVL57_RS02880	COG0494	nUDIX hydrolase
AVL57_RS02885	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
AVL57_RS02890	COG0730	response to heat
AVL57_RS02895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AVL57_RS02900	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AVL57_RS02905	COG2201	protein-glutamate methylesterase activity
AVL57_RS02910	COG3706	GGDEF domain
AVL57_RS02915	COG0784	Response regulator, receiver
AVL57_RS02915	COG5002	protein histidine kinase activity
AVL57_RS02935	COG0564	pseudouridine synthase activity
AVL57_RS02945	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AVL57_RS02955	COG1802	Transcriptional regulator
AVL57_RS02960	COG3119	arylsulfatase activity
AVL57_RS02965	COG1012	belongs to the aldehyde dehydrogenase family
AVL57_RS02970	COG1028	Short-chain dehydrogenase reductase Sdr
AVL57_RS02975	COG1063	alcohol dehydrogenase
AVL57_RS02980	COG4948	Mandelate Racemase Muconate Lactonizing
AVL57_RS02985	COG2814	Major facilitator Superfamily
AVL57_RS02990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVL57_RS03005	COG2124	cytochrome p450
AVL57_RS03105	COG3119	arylsulfatase activity
AVL57_RS03140	COG3119	arylsulfatase activity
AVL57_RS03145	COG3119	arylsulfatase activity
AVL57_RS03155	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AVL57_RS03155	COG1648	precorrin-2 dehydrogenase activity
AVL57_RS03175	COG1538	Outer membrane efflux protein
AVL57_RS03180	COG0494	nUDIX hydrolase
AVL57_RS03195	COG3150	esterase
AVL57_RS03210	COG4251	negative regulation of phosphorylation
AVL57_RS03215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVL57_RS03235	COG1509	lysine 2,3-aminomutase activity
AVL57_RS03240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AVL57_RS03265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AVL57_RS03280	COG0271	Belongs to the BolA IbaG family
AVL57_RS03285	COG0671	phosphoesterase, PA-phosphatase related
AVL57_RS03295	COG3707	response regulator
AVL57_RS03305	COG0659	secondary active sulfate transmembrane transporter activity
AVL57_RS03310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AVL57_RS03315	COG2146	nitrite reductase [NAD(P)H] activity
AVL57_RS03320	COG0243	molybdopterin cofactor binding
AVL57_RS03325	COG1648	precorrin-2 dehydrogenase activity
AVL57_RS03325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AVL57_RS03340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVL57_RS03340	COG1116	anion transmembrane transporter activity
AVL57_RS03345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVL57_RS03350	COG1116	anion transmembrane transporter activity
AVL57_RS03365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AVL57_RS03370	COG4206	TonB-dependent receptor
AVL57_RS03375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AVL57_RS03380	COG0348	domain, Protein
AVL57_RS03395	COG1960	acyl-CoA dehydrogenase activity
AVL57_RS03400	COG1028	Short-chain dehydrogenase reductase Sdr
AVL57_RS03420	COG4948	Mandelate Racemase Muconate Lactonizing
AVL57_RS03435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVL57_RS03440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVL57_RS03465	COG0358	DNA primase activity
AVL57_RS03470	COG1610	YqeY-like protein
AVL57_RS03490	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AVL57_RS03495	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AVL57_RS03510	COG0537	adenosine 5'-monophosphoramidase activity
AVL57_RS03525	COG3135	benzoate transporter
AVL57_RS03530	COG1396	sequence-specific DNA binding
AVL57_RS03535	COG2974	May be involved in recombination
AVL57_RS03540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVL57_RS03540	COG4191	Histidine kinase
AVL57_RS03545	COG0745	RESPONSE REGULATOR receiver
AVL57_RS03550	COG5002	protein histidine kinase activity
AVL57_RS03580	COG0811	peptide transport
AVL57_RS03585	COG0811	peptide transport
AVL57_RS03590	COG0848	biopolymer transport protein
AVL57_RS03595	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AVL57_RS03605	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AVL57_RS03610	COG3437	response regulator, receiver
AVL57_RS03630	COG2133	pyrroloquinoline quinone binding
AVL57_RS03635	COG1049	propionate catabolic process, 2-methylcitrate cycle
AVL57_RS03655	COG0527	aspartate kinase activity
AVL57_RS03660	COG0840	transmembrane signaling receptor activity
AVL57_RS03665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AVL57_RS03675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AVL57_RS03680	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AVL57_RS03685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVL57_RS03690	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AVL57_RS03695	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AVL57_RS03705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AVL57_RS03725	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AVL57_RS03735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AVL57_RS03740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AVL57_RS03745	COG3956	TIGRFAM MazG family protein
AVL57_RS03765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AVL57_RS03770	COG1595	DNA-templated transcription, initiation
AVL57_RS03780	COG4206	TonB-dependent receptor
AVL57_RS03790	COG1473	amidohydrolase
AVL57_RS03795	COG0723	plastoquinol--plastocyanin reductase activity
AVL57_RS03800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AVL57_RS03805	COG2857	Cytochrome c1
AVL57_RS03810	COG0625	glutathione transferase activity
AVL57_RS03815	COG2969	positive regulation of protein catabolic process
AVL57_RS03820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVL57_RS03820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVL57_RS03825	COG2207	Transcriptional regulator
AVL57_RS03825	COG3708	Transcriptional regulator
AVL57_RS03835	COG2239	Acts as a magnesium transporter
AVL57_RS03840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVL57_RS03865	COG1137	ATPase activity
AVL57_RS03880	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AVL57_RS03895	COG1127	ABC transporter
AVL57_RS03900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AVL57_RS03905	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AVL57_RS03910	COG2854	intermembrane phospholipid transfer
AVL57_RS03920	COG5007	Belongs to the BolA IbaG family
AVL57_RS03930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVL57_RS03935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVL57_RS03945	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AVL57_RS03960	COG2207	Transcriptional regulator
AVL57_RS03975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVL57_RS03990	COG3300	MHYT domain
AVL57_RS03990	COG5001	Diguanylate cyclase
AVL57_RS03995	COG2205	protein histidine kinase activity
AVL57_RS03995	COG0784	Response regulator, receiver
AVL57_RS04005	COG2207	Transcriptional regulator
AVL57_RS04010	COG1979	alcohol dehydrogenase
AVL57_RS04035	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AVL57_RS04045	COG0126	phosphoglycerate kinase activity
AVL57_RS04050	COG3588	fructose-bisphosphate aldolase
AVL57_RS04060	COG0823	Involved in the tonB-independent uptake of proteins
AVL57_RS04060	COG1506	peptidase
AVL57_RS04060	COG4946	Tricorn protease homolog
AVL57_RS04065	COG0248	Ppx GppA phosphatase
AVL57_RS04070	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AVL57_RS04080	COG0573	inorganic phosphate transmembrane transporter activity
AVL57_RS04085	COG0581	inorganic phosphate transmembrane transporter activity
AVL57_RS04090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AVL57_RS04100	COG0306	phosphate transporter
AVL57_RS04110	COG0583	DNA-binding transcription factor activity
AVL57_RS04135	COG1272	protein, Hemolysin III
AVL57_RS04155	COG0477	Major facilitator Superfamily
AVL57_RS04160	COG2207	Transcriptional regulator
AVL57_RS04160	COG1609	Transcriptional regulator
AVL57_RS04165	COG1070	Carbohydrate kinase
AVL57_RS04170	COG2115	Belongs to the xylose isomerase family
AVL57_RS04175	COG3291	Pkd domain containing protein
AVL57_RS04175	COG4447	cellulose binding
AVL57_RS04175	COG5520	Belongs to the glycosyl hydrolase 30 family
AVL57_RS04180	COG2207	Transcriptional regulator
AVL57_RS04195	COG1472	Belongs to the glycosyl hydrolase 3 family
AVL57_RS04200	COG1846	Transcriptional regulator
AVL57_RS04205	COG1764	response to oxidative stress
AVL57_RS04220	COG1739	Uncharacterized protein family UPF0029
AVL57_RS04230	COG0420	3'-5' exonuclease activity
AVL57_RS04235	COG0419	ATPase involved in DNA repair
AVL57_RS04240	COG3706	GGDEF domain
AVL57_RS04250	COG2971	BadF BadG BcrA BcrD
AVL57_RS04255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AVL57_RS04260	COG1752	Esterase of the alpha-beta hydrolase superfamily
AVL57_RS04265	COG0488	(ABC) transporter
AVL57_RS04300	COG4667	esterase of the alpha-beta hydrolase superfamily
AVL57_RS04400	COG1346	cytolysis
AVL57_RS04430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AVL57_RS04440	COG0513	Belongs to the DEAD box helicase family
AVL57_RS04450	COG3409	Peptidoglycan-binding domain 1 protein
AVL57_RS04450	COG3267	Type II secretory pathway component ExeA
AVL57_RS04460	COG0784	Response regulator, receiver
AVL57_RS04460	COG3437	response regulator, receiver
AVL57_RS04465	COG0066	3-isopropylmalate dehydratase activity
AVL57_RS04475	COG0473	3-isopropylmalate dehydrogenase activity
AVL57_RS04480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVL57_RS04510	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AVL57_RS04525	COG4555	ABC transporter
AVL57_RS04530	COG1668	transmembrane transport
AVL57_RS04550	COG4133	protoheme IX ABC transporter activity
AVL57_RS04555	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AVL57_RS04560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AVL57_RS04565	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AVL57_RS04575	COG1138	Cytochrome C-type biogenesis protein
AVL57_RS04580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AVL57_RS04595	COG2853	Lipoprotein
AVL57_RS04600	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AVL57_RS04625	COG1682	transport, permease protein
AVL57_RS04655	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AVL57_RS04660	COG1596	polysaccharide export
AVL57_RS04660	COG1555	photosystem II stabilization
AVL57_RS04665	COG0473	3-isopropylmalate dehydrogenase activity
AVL57_RS04680	COG1611	Belongs to the LOG family
AVL57_RS04690	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AVL57_RS04690	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AVL57_RS04760	COG0564	pseudouridine synthase activity
AVL57_RS04775	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AVL57_RS04780	COG0024	Methionine aminopeptidase
AVL57_RS04785	COG0052	Belongs to the universal ribosomal protein uS2 family
AVL57_RS04795	COG0528	UMP kinase activity
AVL57_RS04805	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AVL57_RS04810	COG0575	Belongs to the CDS family
AVL57_RS04815	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AVL57_RS04820	COG0750	zinc metalloprotease
AVL57_RS04835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AVL57_RS04840	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVL57_RS04855	COG0587	DNA-directed DNA polymerase activity
AVL57_RS04860	COG0825	malonyl-CoA metabolic process
AVL57_RS04865	COG0037	tRNA processing
AVL57_RS04895	COG0047	phosphoribosylformylglycinamidine synthase activity
AVL57_RS04895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AVL57_RS04900	COG2840	Smr protein MutS2
AVL57_RS04920	COG0513	Belongs to the DEAD box helicase family
AVL57_RS04925	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AVL57_RS04930	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AVL57_RS04935	COG0583	DNA-binding transcription factor activity
AVL57_RS04955	COG1760	l-serine dehydratase
AVL57_RS04960	COG0494	nUDIX hydrolase
AVL57_RS04965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AVL57_RS04980	COG1404	Belongs to the peptidase S8 family
AVL57_RS04985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AVL57_RS04990	COG0022	dehydrogenase e1 component
AVL57_RS04995	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVL57_RS05000	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AVL57_RS05005	COG0515	serine threonine protein kinase
AVL57_RS05010	COG1946	Acyl-CoA thioesterase
AVL57_RS05020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AVL57_RS05030	COG1956	GAF domain-containing protein
AVL57_RS05045	COG0793	Belongs to the peptidase S41A family
AVL57_RS05050	COG0733	neurotransmitter:sodium symporter activity
AVL57_RS05055	COG1757	Na H antiporter
AVL57_RS05060	COG0308	aminopeptidase N
AVL57_RS05090	COG2902	Dehydrogenase
AVL57_RS05095	COG0167	dihydroorotate dehydrogenase activity
AVL57_RS05110	COG0488	(ABC) transporter
AVL57_RS05120	COG3130	regulation of translation
AVL57_RS05125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AVL57_RS05135	COG0415	Belongs to the DNA photolyase family
AVL57_RS05140	COG0415	Belongs to the DNA photolyase family
AVL57_RS05145	COG3046	protein related to deoxyribodipyrimidine photolyase
AVL57_RS05170	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AVL57_RS05175	COG0589	response to stress
AVL57_RS05185	COG0069	glutamate synthase activity
AVL57_RS05200	COG2193	ferroxidase activity
AVL57_RS05210	COG3278	Belongs to the heme-copper respiratory oxidase family
AVL57_RS05225	COG2010	Cytochrome c
AVL57_RS05250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVL57_RS05260	COG0037	tRNA processing
AVL57_RS05265	COG1752	Esterase of the alpha-beta hydrolase superfamily
AVL57_RS05285	COG1280	lysine exporter protein (LysE YggA)
AVL57_RS05295	COG2897	thiosulfate sulfurtransferase activity
AVL57_RS05300	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AVL57_RS05305	COG3148	PFAM DTW domain containing protein
AVL57_RS05375	COG0582	viral genome integration into host DNA
AVL57_RS05400	COG0322	excinuclease ABC activity
AVL57_RS05405	COG2197	response regulator
AVL57_RS05410	COG1741	Belongs to the pirin family
AVL57_RS05420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AVL57_RS05450	COG0642	Histidine kinase
AVL57_RS05455	COG0745	RESPONSE REGULATOR receiver
AVL57_RS05480	COG0670	Belongs to the BI1 family
AVL57_RS05490	COG2923	Belongs to the DsrF TusC family
AVL57_RS05500	COG2920	part of a sulfur-relay system
AVL57_RS05505	COG0561	phosphatase activity
AVL57_RS05520	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AVL57_RS05525	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AVL57_RS05530	COG1674	ftsk spoiiie
AVL57_RS05530	COG0531	amino acid
AVL57_RS05540	COG0686	Belongs to the AlaDH PNT family
AVL57_RS05545	COG0284	orotidine-5'-phosphate decarboxylase activity
AVL57_RS05550	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AVL57_RS05555	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AVL57_RS05565	COG0776	regulation of translation
AVL57_RS05570	COG0539	negative regulation of cytoplasmic translation
AVL57_RS05575	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AVL57_RS05580	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AVL57_RS05585	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AVL57_RS05600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AVL57_RS05605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AVL57_RS05610	COG0633	Ferredoxin
AVL57_RS05615	COG5002	protein histidine kinase activity
AVL57_RS05690	COG3547	Transposase (IS116 IS110 IS902 family)
AVL57_RS05720	COG1131	(ABC) transporter
AVL57_RS05755	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AVL57_RS05760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVL57_RS05770	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AVL57_RS05780	COG4783	chaperone-mediated protein folding
AVL57_RS05790	COG1393	Belongs to the ArsC family
AVL57_RS05825	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AVL57_RS05860	COG0572	uridine kinase
AVL57_RS05865	COG3769	mannosylglycerate metabolic process
AVL57_RS05870	COG1215	transferase activity, transferring glycosyl groups
AVL57_RS05880	COG0303	'Molybdopterin
AVL57_RS05885	COG0534	Mate efflux family protein
AVL57_RS05905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AVL57_RS05915	COG0405	Gamma-glutamyltransferase
AVL57_RS05920	COG1024	Enoyl-CoA hydratase
AVL57_RS05955	COG1448	Aminotransferase
AVL57_RS05960	COG1671	Belongs to the UPF0178 family
AVL57_RS05965	COG1028	Short-chain dehydrogenase reductase Sdr
AVL57_RS05975	COG1960	acyl-CoA dehydrogenase activity
AVL57_RS05980	COG2207	Transcriptional regulator
AVL57_RS05980	COG1917	Cupin 2, conserved barrel domain protein
AVL57_RS06030	COG0596	Alpha beta hydrolase
AVL57_RS06040	COG0716	FMN binding
AVL57_RS06060	COG3265	gluconokinase activity
AVL57_RS06065	COG1609	Transcriptional regulator
AVL57_RS06075	COG1984	allophanate hydrolase subunit 2
AVL57_RS06085	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AVL57_RS06090	COG2996	Protein conserved in bacteria
AVL57_RS06095	COG1765	OsmC-like protein
AVL57_RS06100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVL57_RS06110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVL57_RS06125	COG0436	Aminotransferase
AVL57_RS06130	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AVL57_RS06135	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AVL57_RS06145	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AVL57_RS06155	COG1238	metal cluster binding
AVL57_RS06200	COG4628	conserved protein (DUF2132)
AVL57_RS06210	COG0454	-acetyltransferase
AVL57_RS06215	COG1119	ATPase activity
AVL57_RS06225	COG1185	polyribonucleotide nucleotidyltransferase activity
AVL57_RS06240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AVL57_RS06245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AVL57_RS06250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVL57_RS06290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AVL57_RS06295	COG0149	triose-phosphate isomerase activity
AVL57_RS06300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AVL57_RS06305	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AVL57_RS06315	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AVL57_RS06320	COG1534	Rna-binding protein
AVL57_RS06330	COG1067	ATP-dependent peptidase activity
AVL57_RS06335	COG0495	leucyl-tRNA aminoacylation
AVL57_RS06345	COG1466	dna polymerase III delta subunit
AVL57_RS06350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AVL57_RS06355	COG0799	negative regulation of ribosome biogenesis
AVL57_RS06360	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AVL57_RS06365	COG0768	penicillin binding
AVL57_RS06370	COG0772	Belongs to the SEDS family
AVL57_RS06375	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AVL57_RS06380	COG1686	Belongs to the peptidase S11 family
AVL57_RS06385	COG2921	Belongs to the UPF0250 family
AVL57_RS06390	COG0321	lipoyl(octanoyl) transferase activity
AVL57_RS06395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AVL57_RS06405	COG0252	asparaginase activity
AVL57_RS06415	COG0778	Nitroreductase
AVL57_RS06430	COG0616	signal peptide processing
AVL57_RS06450	COG0492	ferredoxin-NADP+ reductase activity
AVL57_RS06455	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AVL57_RS06460	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AVL57_RS06465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AVL57_RS06470	COG0542	response to heat
AVL57_RS06475	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AVL57_RS06480	COG1278	Cold shock
AVL57_RS06490	COG1187	pseudouridine synthase activity
AVL57_RS06495	COG0482	sulfurtransferase activity
AVL57_RS06500	COG2915	High frequency lysogenization protein hflD homolog
AVL57_RS06505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AVL57_RS06515	COG2850	peptidyl-arginine hydroxylation
AVL57_RS06530	COG0277	FAD linked oxidase domain protein
AVL57_RS06530	COG0247	lactate metabolic process
AVL57_RS06535	COG3123	guanosine phosphorylase activity
AVL57_RS06540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AVL57_RS06585	COG1695	Transcriptional regulator
AVL57_RS06600	COG1077	Cell shape determining protein MreB Mrl
AVL57_RS06625	COG3265	gluconokinase activity
AVL57_RS06635	COG1028	Short-chain dehydrogenase reductase Sdr
AVL57_RS06650	COG1609	Transcriptional regulator
AVL57_RS06655	COG0679	Auxin Efflux Carrier
AVL57_RS06675	COG0574	Belongs to the PEP-utilizing enzyme family
AVL57_RS06675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVL57_RS06695	COG1942	4-Oxalocrotonate Tautomerase
AVL57_RS06715	COG1714	RDD family
AVL57_RS06740	COG0702	epimerase
AVL57_RS06750	COG0084	hydrolase, TatD family'
AVL57_RS06755	COG0470	DNA polymerase III
AVL57_RS06765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AVL57_RS06770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AVL57_RS06775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVL57_RS06780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVL57_RS06795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AVL57_RS06800	COG0416	fatty acid biosynthetic process
AVL57_RS06810	COG1399	metal-binding, possibly nucleic acid-binding protein
AVL57_RS06815	COG0424	maF-like protein
AVL57_RS06820	COG0546	phosphoglycolate phosphatase activity
AVL57_RS06830	COG1530	ribonuclease E activity
AVL57_RS06850	COG2153	protein acetylation
AVL57_RS06870	COG0625	glutathione transferase activity
AVL57_RS06885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AVL57_RS06895	COG0583	DNA-binding transcription factor activity
AVL57_RS06905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AVL57_RS06910	COG3724	N-succinylarginine dihydrolase activity
AVL57_RS06920	COG1301	dicarboxylic acid transport
AVL57_RS06925	COG4591	ABC-type transport system involved in lipoprotein release permease component
AVL57_RS06935	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AVL57_RS06970	COG0328	RNA-DNA hybrid ribonuclease activity
AVL57_RS06975	COG0604	alcohol dehydrogenase
AVL57_RS06975	COG3321	synthase
AVL57_RS06995	COG1643	Atp-dependent helicase
AVL57_RS07035	COG4999	Histidine kinase
AVL57_RS07035	COG2205	protein histidine kinase activity
AVL57_RS07035	COG3437	response regulator, receiver
AVL57_RS07035	COG3850	Histidine kinase
AVL57_RS07040	COG2925	Exonuclease
AVL57_RS07055	COG0183	Belongs to the thiolase family
AVL57_RS07060	COG0789	Transcriptional regulator
AVL57_RS07065	COG1960	acyl-CoA dehydrogenase activity
AVL57_RS07070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AVL57_RS07075	COG1024	Enoyl-CoA hydratase
AVL57_RS07080	COG4770	biotin carboxylase activity
AVL57_RS07110	COG1957	nucleoside hydrolase
AVL57_RS07125	COG2814	Major facilitator Superfamily
AVL57_RS07160	COG0708	Exodeoxyribonuclease III
AVL57_RS07175	COG4591	ABC-type transport system involved in lipoprotein release permease component
AVL57_RS07185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AVL57_RS07195	COG2096	Adenosyltransferase
AVL57_RS07200	COG0471	metal ion transport
AVL57_RS07205	COG1472	Belongs to the glycosyl hydrolase 3 family
AVL57_RS07215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AVL57_RS07230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVL57_RS07230	COG0072	phenylalanine-tRNA ligase activity
AVL57_RS07270	COG2244	polysaccharide biosynthetic process
AVL57_RS07280	COG1215	transferase activity, transferring glycosyl groups
AVL57_RS07295	COG0438	transferase activity, transferring glycosyl groups
AVL57_RS07330	COG4464	protein tyrosine phosphatase activity
AVL57_RS07335	COG0489	protein tyrosine kinase activity
AVL57_RS07340	COG1596	polysaccharide export
AVL57_RS07350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AVL57_RS07370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AVL57_RS07385	COG1028	Short-chain dehydrogenase reductase Sdr
AVL57_RS07425	COG0730	response to heat
AVL57_RS07430	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AVL57_RS07445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AVL57_RS07450	COG2233	PERMEase
AVL57_RS07465	COG0784	Response regulator, receiver
AVL57_RS07465	COG5002	protein histidine kinase activity
AVL57_RS07475	COG3300	MHYT domain
AVL57_RS07475	COG5001	Diguanylate cyclase
AVL57_RS07485	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AVL57_RS07490	COG2252	PERMEase
AVL57_RS07505	COG1309	transcriptional regulator
AVL57_RS07515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVL57_RS07530	COG2351	hydroxyisourate hydrolase activity
AVL57_RS07535	COG0402	S-adenosylhomocysteine deaminase activity
AVL57_RS07545	COG3447	MASE1 domain protein
AVL57_RS07545	COG5001	Diguanylate cyclase
AVL57_RS07545	COG5002	protein histidine kinase activity
AVL57_RS07565	COG3706	GGDEF domain
AVL57_RS07580	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AVL57_RS07600	COG2190	(PTS) system
AVL57_RS07600	COG2211	Major facilitator Superfamily
AVL57_RS07605	COG1393	Belongs to the ArsC family
AVL57_RS07635	COG2988	succinylglutamate desuccinylase activity
AVL57_RS07645	COG0058	SHG alpha-glucan phosphorylase activity
AVL57_RS07650	COG0033	Phosphoglucomutase
AVL57_RS07655	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AVL57_RS07660	COG0714	Associated with various cellular activities
AVL57_RS07675	COG2116	formate transmembrane transporter activity
AVL57_RS07680	COG0515	serine threonine protein kinase
AVL57_RS07680	COG2815	serine threonine protein kinase
AVL57_RS07685	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
AVL57_RS07690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AVL57_RS07710	COG0583	DNA-binding transcription factor activity
AVL57_RS07720	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AVL57_RS07730	COG0784	Response regulator, receiver
AVL57_RS07730	COG3437	response regulator, receiver
AVL57_RS07735	COG2890	protein-(glutamine-N5) methyltransferase activity
AVL57_RS07745	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AVL57_RS07750	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AVL57_RS07755	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AVL57_RS07765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AVL57_RS07770	COG5001	Diguanylate cyclase
AVL57_RS07780	COG1064	alcohol dehydrogenase
AVL57_RS07795	COG0012	GTP binding
AVL57_RS07800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AVL57_RS07825	COG1115	amino acid carrier protein
AVL57_RS07830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVL57_RS07845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVL57_RS07855	COG1702	phosphate starvation-inducible protein PhoH
AVL57_RS07865	COG4535	Mg2 and Co2 transporter CorC
AVL57_RS07870	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AVL57_RS07875	COG0280	phosphate acetyltransferase
AVL57_RS07875	COG0857	belongs to the CobB CobQ family
AVL57_RS07885	COG0071	Belongs to the small heat shock protein (HSP20) family
AVL57_RS07915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AVL57_RS07920	COG0505	Belongs to the CarA family
AVL57_RS07925	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AVL57_RS07940	COG3706	GGDEF domain
AVL57_RS07940	COG5001	Diguanylate cyclase
AVL57_RS07940	COG4251	negative regulation of phosphorylation
AVL57_RS07940	COG2203	Gaf domain
AVL57_RS07945	COG3909	cytochrome
AVL57_RS07950	COG0484	heat shock protein binding
AVL57_RS07960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AVL57_RS07965	COG2205	protein histidine kinase activity
AVL57_RS07965	COG0784	Response regulator, receiver
AVL57_RS07975	COG4771	TonB-dependent receptor
AVL57_RS07980	COG2610	gluconate transmembrane transporter activity
AVL57_RS07985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVL57_RS07995	COG1028	Short-chain dehydrogenase reductase Sdr
AVL57_RS08000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AVL57_RS08005	COG0497	DNA recombination
AVL57_RS08010	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVL57_RS08015	COG0500	methyltransferase
AVL57_RS08020	COG2733	membrane
AVL57_RS08035	COG0110	maltose O-acetyltransferase activity
AVL57_RS08040	COG0656	L-ascorbic acid biosynthetic process
AVL57_RS08055	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AVL57_RS08060	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AVL57_RS08065	COG0009	L-threonylcarbamoyladenylate synthase
AVL57_RS08070	COG0613	PHP domain protein
AVL57_RS08075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AVL57_RS08085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AVL57_RS08090	COG0134	indole-3-glycerol-phosphate synthase activity
AVL57_RS08090	COG0135	phosphoribosylanthranilate isomerase activity
AVL57_RS08100	COG0159	tryptophan synthase activity
AVL57_RS08105	COG2350	Protein conserved in bacteria
AVL57_RS08125	COG2205	protein histidine kinase activity
AVL57_RS08130	COG0628	permease
AVL57_RS08135	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AVL57_RS08140	COG1090	epimerase
AVL57_RS08145	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AVL57_RS08150	COG4181	ATPase activity
AVL57_RS08170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AVL57_RS08205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVL57_RS08225	COG0745	RESPONSE REGULATOR receiver
AVL57_RS08235	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AVL57_RS08240	COG5265	(ABC) transporter
AVL57_RS08255	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AVL57_RS08265	COG4139	cobalamin transport
AVL57_RS08270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AVL57_RS08285	COG1073	alpha beta
AVL57_RS08285	COG2226	methyltransferase
AVL57_RS08290	COG0156	8-amino-7-oxononanoate synthase activity
AVL57_RS08315	COG0456	acetyltransferase
AVL57_RS08320	COG0189	ligase activity
AVL57_RS08335	COG0017	Asparaginyl-tRNA synthetase
AVL57_RS08345	COG2995	paraquat-inducible protein a
AVL57_RS08350	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AVL57_RS08350	COG3008	intermembrane lipid transfer
AVL57_RS08380	COG0583	DNA-binding transcription factor activity
AVL57_RS08385	COG1309	transcriptional regulator
AVL57_RS08395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVL57_RS08400	COG0517	IMP dehydrogenase activity
AVL57_RS08415	COG0583	DNA-binding transcription factor activity
AVL57_RS08420	COG3038	cytochrome b561
AVL57_RS08455	COG2271	Major facilitator Superfamily
AVL57_RS08460	COG2205	protein histidine kinase activity
AVL57_RS08460	COG0784	Response regulator, receiver
AVL57_RS08535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AVL57_RS08555	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AVL57_RS08560	COG2885	chlorophyll binding
AVL57_RS08565	COG0823	Involved in the tonB-independent uptake of proteins
AVL57_RS08580	COG0811	peptide transport
AVL57_RS08585	COG0824	Thioesterase
AVL57_RS08590	COG2255	four-way junction helicase activity
AVL57_RS08595	COG0632	four-way junction helicase activity
AVL57_RS08600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AVL57_RS08605	COG0494	nUDIX hydrolase
AVL57_RS08610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AVL57_RS08625	COG2204	response regulator
AVL57_RS08635	COG2205	protein histidine kinase activity
AVL57_RS08665	COG0023	Translation Initiation Factor
AVL57_RS08670	COG0745	RESPONSE REGULATOR receiver
AVL57_RS08675	COG1605	Chorismate mutase
AVL57_RS08675	COG0077	Prephenate dehydratase
AVL57_RS08680	COG0840	transmembrane signaling receptor activity
AVL57_RS08685	COG0287	Prephenate dehydrogenase
AVL57_RS08685	COG1605	Chorismate mutase
AVL57_RS08690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AVL57_RS08695	COG2860	membrane
AVL57_RS08710	COG0335	large ribosomal subunit rRNA binding
AVL57_RS08715	COG0336	Belongs to the RNA methyltransferase TrmD family
AVL57_RS08720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AVL57_RS08725	COG0228	four-way junction DNA binding
AVL57_RS08740	COG2873	o-acetylhomoserine
AVL57_RS08745	COG1132	(ABC) transporter
AVL57_RS08750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVL57_RS08760	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AVL57_RS08790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AVL57_RS08795	COG4137	Cytochrome C assembly protein
AVL57_RS08800	COG4536	flavin adenine dinucleotide binding
AVL57_RS08810	COG2062	phosphohistidine phosphatase, SixA
AVL57_RS08815	COG1025	Belongs to the peptidase M16 family
AVL57_RS08830	COG1024	Enoyl-CoA hydratase
AVL57_RS08830	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVL57_RS08840	COG0714	Associated with various cellular activities
AVL57_RS08860	COG2304	oxidoreductase activity
AVL57_RS08885	COG3706	GGDEF domain
AVL57_RS08890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVL57_RS08895	COG0175	sulfate reduction
AVL57_RS08900	COG0529	Catalyzes the synthesis of activated sulfate
AVL57_RS08915	COG3273	potassium ion transport
AVL57_RS08915	COG0471	metal ion transport
AVL57_RS08940	COG0367	asparagine synthase
AVL57_RS08950	COG0602	queuosine metabolic process
AVL57_RS08975	COG0556	nucleotide-excision repair
AVL57_RS08980	COG0534	Mate efflux family protein
AVL57_RS08995	COG4657	Part of a membrane complex involved in electron transport
AVL57_RS09000	COG2878	Part of a membrane complex involved in electron transport
AVL57_RS09005	COG4656	Part of a membrane complex involved in electron transport
AVL57_RS09010	COG4658	electron transport chain
AVL57_RS09015	COG4659	FMN binding
AVL57_RS09020	COG4660	Part of a membrane complex involved in electron transport
AVL57_RS09025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AVL57_RS09045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AVL57_RS09050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVL57_RS09055	COG0823	Involved in the tonB-independent uptake of proteins
AVL57_RS09055	COG1506	peptidase
AVL57_RS09055	COG4946	Tricorn protease homolog
AVL57_RS09080	COG1278	Cold shock
AVL57_RS09085	COG0346	lactoylglutathione lyase activity
AVL57_RS09090	COG0584	glycerophosphoryl diester phosphodiesterase
AVL57_RS09095	COG2885	chlorophyll binding
AVL57_RS09100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AVL57_RS09105	COG0450	alkyl hydroperoxide reductase
AVL57_RS09130	COG4771	TonB-dependent receptor
AVL57_RS09135	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AVL57_RS09140	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AVL57_RS09145	COG2766	serine protein kinase
AVL57_RS09150	COG2718	Belongs to the UPF0229 family
AVL57_RS09155	COG2719	SpoVR family
AVL57_RS09175	COG2890	protein-(glutamine-N5) methyltransferase activity
AVL57_RS09180	COG2840	Smr protein MutS2
AVL57_RS09205	COG1136	(ABC) transporter
AVL57_RS09225	COG2918	glutathione biosynthetic process
AVL57_RS09230	COG0612	Peptidase, M16
AVL57_RS09240	COG0564	pseudouridine synthase activity
AVL57_RS09245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AVL57_RS09250	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AVL57_RS09275	COG2175	clavaminate synthase activity
AVL57_RS09305	COG0583	DNA-binding transcription factor activity
AVL57_RS09320	COG0456	acetyltransferase
AVL57_RS09375	COG0848	biopolymer transport protein
AVL57_RS09380	COG0811	peptide transport
AVL57_RS09385	COG0811	peptide transport
AVL57_RS09425	COG0457	Tetratricopeptide repeat
AVL57_RS09455	COG1522	sequence-specific DNA binding
AVL57_RS09460	COG0625	glutathione transferase activity
AVL57_RS09490	COG1842	Phage shock protein A
AVL57_RS09495	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AVL57_RS09500	COG0747	negative chemotaxis
AVL57_RS09505	COG4168	peptide transport system, permease
AVL57_RS09510	COG4171	peptide transport system, permease
AVL57_RS09515	COG4172	Belongs to the ABC transporter superfamily
AVL57_RS09520	COG4172	Belongs to the ABC transporter superfamily
AVL57_RS09525	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AVL57_RS09540	COG1607	acyl-coa hydrolase
AVL57_RS09565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AVL57_RS09580	COG3590	peptidase
AVL57_RS09585	COG1309	transcriptional regulator
AVL57_RS09595	COG0659	secondary active sulfate transmembrane transporter activity
AVL57_RS09600	COG0288	reversible hydration of carbon dioxide
AVL57_RS09605	COG0583	DNA-binding transcription factor activity
AVL57_RS09610	COG0583	DNA-binding transcription factor activity
AVL57_RS09620	COG1410	methionine synthase
AVL57_RS09620	COG0646	methionine synthase
AVL57_RS09625	COG0646	methionine synthase
AVL57_RS09625	COG1410	methionine synthase
AVL57_RS09640	COG0835	chemotaxis
AVL57_RS09650	COG1192	Involved in chromosome partitioning
AVL57_RS09655	COG2201	protein-glutamate methylesterase activity
AVL57_RS09660	COG0643	Histidine kinase
AVL57_RS09660	COG0784	Response regulator, receiver
AVL57_RS09660	COG2198	Histidine kinase
AVL57_RS09665	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AVL57_RS09690	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AVL57_RS09705	COG1987	bacterial-type flagellum assembly
AVL57_RS09755	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AVL57_RS09760	COG1766	The M ring may be actively involved in energy transduction
AVL57_RS09790	COG1086	Polysaccharide biosynthesis protein
AVL57_RS09795	COG1083	cytidylyl-transferase
AVL57_RS09805	COG2089	acid synthase
AVL57_RS09820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL57_RS09860	COG2089	acid synthase
AVL57_RS09865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AVL57_RS09870	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AVL57_RS09910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AVL57_RS09915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AVL57_RS09935	COG1256	bacterial-type flagellum assembly
AVL57_RS09940	COG3951	Flagellar rod assembly protein muramidase FlgJ
AVL57_RS09940	COG1705	Flagellar rod assembly protein muramidase FlgJ
AVL57_RS09960	COG4787	bacterial-type flagellum-dependent cell motility
AVL57_RS09965	COG1749	Flagellar hook protein flgE
AVL57_RS09980	COG1815	bacterial-type flagellum-dependent cell motility
AVL57_RS09985	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AVL57_RS09990	COG0784	Response regulator, receiver
AVL57_RS09990	COG0835	chemotaxis
AVL57_RS10030	COG2197	response regulator
AVL57_RS10035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVL57_RS10045	COG2885	chlorophyll binding
AVL57_RS10140	COG1054	Belongs to the UPF0176 family
AVL57_RS10150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVL57_RS10150	COG2205	protein histidine kinase activity
AVL57_RS10160	COG0205	6-phosphofructokinase activity
AVL57_RS10165	COG3279	Response regulator of the LytR AlgR family
AVL57_RS10170	COG3275	phosphorelay sensor kinase activity
AVL57_RS10200	COG3081	Nucleoid-associated protein
AVL57_RS10205	COG3082	Protein of unknown function (DUF1414)
AVL57_RS10210	COG3083	sulfuric ester hydrolase activity
AVL57_RS10220	COG2226	methyltransferase
AVL57_RS10225	COG1024	Enoyl-CoA hydratase
AVL57_RS10230	COG1960	acyl-CoA dehydrogenase activity
AVL57_RS10240	COG2084	Dehydrogenase
AVL57_RS10245	COG0386	Belongs to the glutathione peroxidase family
AVL57_RS10250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVL57_RS10255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVL57_RS10260	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AVL57_RS10285	COG0616	signal peptide processing
AVL57_RS10295	COG2267	carboxylic ester hydrolase activity
AVL57_RS10300	COG1028	Short-chain dehydrogenase reductase Sdr
AVL57_RS10310	COG1609	Transcriptional regulator
AVL57_RS10325	COG0366	Alpha amylase catalytic
AVL57_RS10345	COG4667	esterase of the alpha-beta hydrolase superfamily
AVL57_RS10380	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVL57_RS10385	COG0567	Dehydrogenase, E1 component
AVL57_RS10395	COG1053	succinate dehydrogenase
AVL57_RS10400	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AVL57_RS10425	COG0435	Glutathione S-transferase
AVL57_RS10430	COG0579	oxidoreductase
AVL57_RS10435	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AVL57_RS10475	COG1663	tetraacyldisaccharide 4'-kinase activity
AVL57_RS10480	COG1132	(ABC) transporter
AVL57_RS10495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AVL57_RS10505	COG1196	nuclear chromosome segregation
AVL57_RS10525	COG0295	cytidine deaminase activity
AVL57_RS10550	COG0477	Major facilitator Superfamily
AVL57_RS10570	COG2318	DinB family
AVL57_RS10575	COG0457	Tetratricopeptide repeat
AVL57_RS10585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AVL57_RS10595	COG2914	Belongs to the UPF0125 (RnfH) family
AVL57_RS10600	COG2867	negative regulation of translational initiation
AVL57_RS10625	COG4771	TonB-dependent receptor
AVL57_RS10630	COG2814	Major facilitator Superfamily
AVL57_RS10660	COG1012	belongs to the aldehyde dehydrogenase family
AVL57_RS10670	COG1595	DNA-templated transcription, initiation
AVL57_RS10700	COG0583	DNA-binding transcription factor activity
AVL57_RS10720	COG5001	Diguanylate cyclase
AVL57_RS10720	COG3300	MHYT domain
AVL57_RS10735	COG2203	Gaf domain
AVL57_RS10735	COG3706	GGDEF domain
AVL57_RS10735	COG5001	Diguanylate cyclase
AVL57_RS10735	COG4251	negative regulation of phosphorylation
AVL57_RS10750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AVL57_RS10755	COG4136	ATPase activity
AVL57_RS10760	COG4135	transport system, permease component
AVL57_RS10765	COG4134	Bacterial extracellular solute-binding protein
AVL57_RS10780	COG4771	TonB-dependent receptor
AVL57_RS10795	COG1032	radical SAM domain protein
AVL57_RS10820	COG4774	siderophore transport
AVL57_RS10855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVL57_RS10855	COG3153	acetyltransferase
AVL57_RS10865	COG0596	Alpha beta hydrolase
AVL57_RS10870	COG3706	GGDEF domain
AVL57_RS10880	COG4269	membrane
AVL57_RS10890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AVL57_RS10905	COG0195	Participates in both transcription termination and antitermination
AVL57_RS10915	COG3437	response regulator, receiver
AVL57_RS10920	COG0784	Response regulator, receiver
AVL57_RS10920	COG2205	protein histidine kinase activity
AVL57_RS10920	COG2198	Histidine kinase
AVL57_RS10940	COG4771	TonB-dependent receptor
AVL57_RS10945	COG0668	transmembrane transport
AVL57_RS10965	COG0668	transmembrane transport
AVL57_RS10985	COG0246	Mannitol dehydrogenase
AVL57_RS10995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVL57_RS11000	COG2390	Transcriptional regulator
AVL57_RS11015	COG0596	Alpha beta hydrolase
AVL57_RS11020	COG1960	acyl-CoA dehydrogenase activity
AVL57_RS11025	COG0183	Belongs to the thiolase family
AVL57_RS11030	COG1024	Enoyl-CoA hydratase
AVL57_RS11030	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVL57_RS11035	COG0596	Alpha beta hydrolase
AVL57_RS11065	COG1960	acyl-CoA dehydrogenase activity
AVL57_RS11075	COG4771	TonB-dependent receptor
AVL57_RS11095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AVL57_RS11100	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AVL57_RS11115	COG0314	molybdopterin synthase activity
AVL57_RS11120	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AVL57_RS11125	COG0315	cyclic pyranopterin monophosphate synthase activity
AVL57_RS11130	COG0521	Mo-molybdopterin cofactor biosynthetic process
AVL57_RS11135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AVL57_RS11330	COG1028	Short-chain dehydrogenase reductase Sdr
AVL57_RS11365	COG0436	Aminotransferase
AVL57_RS11370	COG3268	Saccharopine dehydrogenase
AVL57_RS11385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVL57_RS11400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AVL57_RS11405	COG1074	ATP-dependent DNA helicase activity
AVL57_RS11410	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AVL57_RS11420	COG1022	Amp-dependent synthetase and ligase
AVL57_RS11425	COG5001	Diguanylate cyclase
AVL57_RS11425	COG3300	MHYT domain
AVL57_RS11435	COG3132	Protein of unknown function, DUF480
AVL57_RS11450	COG0583	DNA-binding transcription factor activity
AVL57_RS11470	COG0640	Transcriptional regulator
AVL57_RS11480	COG0583	DNA-binding transcription factor activity
AVL57_RS11490	COG2204	response regulator
AVL57_RS11500	COG4251	negative regulation of phosphorylation
AVL57_RS11505	COG0784	Response regulator, receiver
AVL57_RS11510	COG2205	protein histidine kinase activity
AVL57_RS11510	COG0784	Response regulator, receiver
AVL57_RS11535	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AVL57_RS11560	COG3139	Protein of unknown function (DUF1315)
AVL57_RS11570	COG1115	amino acid carrier protein
AVL57_RS11575	COG2866	Carboxypeptidase
AVL57_RS11595	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AVL57_RS11605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AVL57_RS11610	COG1640	4-alpha-glucanotransferase
AVL57_RS11620	COG0676	glucose-6-phosphate 1-epimerase activity
AVL57_RS11625	COG0800	Aldolase
AVL57_RS11635	COG0129	dihydroxy-acid dehydratase activity
AVL57_RS11645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AVL57_RS11650	COG1737	Transcriptional regulator
AVL57_RS11655	COG0469	pyruvate kinase activity
AVL57_RS11660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AVL57_RS11705	COG2205	protein histidine kinase activity
AVL57_RS11710	COG0745	RESPONSE REGULATOR receiver
AVL57_RS11735	COG3665	Urea carboxylase-associated protein
AVL57_RS11745	COG1028	Short-chain dehydrogenase reductase Sdr
AVL57_RS11750	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AVL57_RS11775	COG2721	sulfolactate sulfo-lyase activity
AVL57_RS11780	COG1904	glucuronate isomerase
AVL57_RS11785	COG0246	Mannitol dehydrogenase
AVL57_RS11790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVL57_RS11795	COG2755	lipolytic protein G-D-S-L family
AVL57_RS11805	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AVL57_RS11815	COG4677	pectinesterase activity
AVL57_RS11835	COG2356	endonuclease I
AVL57_RS11845	COG1024	Enoyl-CoA hydratase
AVL57_RS11865	COG1609	Transcriptional regulator
AVL57_RS11870	COG4948	Mandelate Racemase Muconate Lactonizing
AVL57_RS11875	COG0673	inositol 2-dehydrogenase activity
AVL57_RS11890	COG3300	MHYT domain
AVL57_RS11890	COG5001	Diguanylate cyclase
AVL57_RS11905	COG0746	molybdenum cofactor guanylyltransferase activity
AVL57_RS11915	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVL57_RS11920	COG1764	response to oxidative stress
AVL57_RS11945	COG0745	RESPONSE REGULATOR receiver
AVL57_RS11950	COG5002	protein histidine kinase activity
AVL57_RS11950	COG3850	Histidine kinase
AVL57_RS11985	COG0738	Major facilitator superfamily
AVL57_RS12010	COG0840	transmembrane signaling receptor activity
AVL57_RS12020	COG0753	catalase activity
AVL57_RS12030	COG0330	HflC and HflK could
AVL57_RS12050	COG0778	Nitroreductase
AVL57_RS12070	COG0471	metal ion transport
AVL57_RS12080	COG0489	protein tyrosine kinase activity
AVL57_RS12085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVL57_RS12085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVL57_RS12090	COG2226	methyltransferase
AVL57_RS12095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVL57_RS12100	COG0741	lytic transglycosylase activity
AVL57_RS12100	COG1388	LysM domain
AVL57_RS12120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AVL57_RS12130	COG1785	Belongs to the alkaline phosphatase family
AVL57_RS12135	COG1785	Belongs to the alkaline phosphatase family
AVL57_RS12150	COG2268	Band 7 protein
AVL57_RS12170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVL57_RS12175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVL57_RS12180	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AVL57_RS12185	COG2080	2 iron, 2 sulfur cluster binding
AVL57_RS12195	COG0604	alcohol dehydrogenase
AVL57_RS12205	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AVL57_RS12220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AVL57_RS12225	COG1286	toxin biosynthetic process
AVL57_RS12230	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AVL57_RS12235	COG0285	dihydrofolate synthase activity
AVL57_RS12245	COG0101	tRNA pseudouridine synthase activity
AVL57_RS12260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVL57_RS12280	COG3706	GGDEF domain
AVL57_RS12285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVL57_RS12285	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AVL57_RS12315	COG3101	peptidyl-lysine hydroxylation
AVL57_RS12350	COG2207	Transcriptional regulator
AVL57_RS12355	COG1073	alpha beta
AVL57_RS12380	COG2826	transposase and inactivated derivatives, IS30 family
AVL57_RS12420	COG0789	Transcriptional regulator
AVL57_RS12445	COG1902	pentaerythritol trinitrate reductase activity
AVL57_RS12445	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVL57_RS12470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL57_RS12475	COG1309	transcriptional regulator
AVL57_RS12480	COG4399	Belongs to the UPF0754 family
AVL57_RS12515	COG2186	Transcriptional regulator
AVL57_RS12525	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AVL57_RS12530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVL57_RS12535	COG2983	Belongs to the UPF0260 family
AVL57_RS12540	COG0179	Fumarylacetoacetate (FAA) hydrolase
AVL57_RS12555	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AVL57_RS12560	COG0318	PFAM AMP-dependent synthetase and ligase
AVL57_RS12565	COG2267	carboxylic ester hydrolase activity
AVL57_RS12580	COG1214	PFAM Peptidase M22, glycoprotease
AVL57_RS12585	COG1199	ATP-dependent helicase activity
AVL57_RS12640	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AVL57_RS12645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AVL57_RS12650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVL57_RS12655	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AVL57_RS12655	COG0131	Imidazoleglycerol-phosphate dehydratase
AVL57_RS12660	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AVL57_RS12675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AVL57_RS12675	COG0140	phosphoribosyl-ATP diphosphatase activity
AVL57_RS12685	COG1028	Short-chain dehydrogenase reductase Sdr
AVL57_RS12695	COG1022	Amp-dependent synthetase and ligase
AVL57_RS12715	COG0463	Glycosyl transferase, family 2
AVL57_RS12735	COG0642	Histidine kinase
AVL57_RS12745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVL57_RS12770	COG0326	Molecular chaperone. Has ATPase activity
AVL57_RS12775	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AVL57_RS12800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AVL57_RS12805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AVL57_RS12815	COG3220	belongs to the UPF0276 family
AVL57_RS12825	COG2319	Wd-40 repeat
AVL57_RS12825	COG4249	Peptidase C14 caspase catalytic subunit p20
AVL57_RS12840	COG3706	GGDEF domain
AVL57_RS12840	COG2203	Gaf domain
AVL57_RS12840	COG4251	negative regulation of phosphorylation
AVL57_RS12840	COG5001	Diguanylate cyclase
AVL57_RS12875	COG1183	phosphatidylcholine synthase activity
AVL57_RS12895	COG0542	response to heat
AVL57_RS12900	COG1496	oxidoreductase activity
AVL57_RS12905	COG0564	pseudouridine synthase activity
AVL57_RS12920	COG1595	DNA-templated transcription, initiation
AVL57_RS12935	COG4221	oxidoreductase activity
AVL57_RS12940	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AVL57_RS12950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AVL57_RS12960	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AVL57_RS12965	COG1722	exodeoxyribonuclease VII activity
AVL57_RS12970	COG0142	geranyltranstransferase activity
AVL57_RS12980	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AVL57_RS12985	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AVL57_RS12995	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AVL57_RS13010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVL57_RS13010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVL57_RS13025	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVL57_RS13030	COG0488	(ABC) transporter
AVL57_RS13040	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AVL57_RS13050	COG0560	Phosphoserine phosphatase
AVL57_RS13060	COG0084	hydrolase, TatD family'
AVL57_RS13105	COG1595	DNA-templated transcription, initiation
AVL57_RS13110	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AVL57_RS13125	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AVL57_RS13145	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AVL57_RS13205	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AVL57_RS13210	COG1047	Peptidyl-prolyl cis-trans
AVL57_RS13220	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AVL57_RS13225	COG0196	riboflavin kinase activity
AVL57_RS13230	COG0728	peptidoglycan biosynthetic process
AVL57_RS13235	COG0268	Binds directly to 16S ribosomal RNA
AVL57_RS13255	COG0385	Bile acid
AVL57_RS13280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVL57_RS13285	COG0776	regulation of translation
AVL57_RS13290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AVL57_RS13295	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AVL57_RS13300	COG0740	serine-type endopeptidase activity
AVL57_RS13305	COG0544	peptidyl-prolyl cis-trans isomerase activity
AVL57_RS13345	COG1720	tRNA m6t6A37 methyltransferase activity
AVL57_RS13365	COG0123	including yeast histone deacetylase and acetoin utilization protein
AVL57_RS13385	COG0517	IMP dehydrogenase activity
AVL57_RS13385	COG0516	GMP reductase activity
AVL57_RS13390	COG1570	exodeoxyribonuclease VII activity
AVL57_RS13405	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVL57_RS13410	COG2976	Protein conserved in bacteria
AVL57_RS13435	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AVL57_RS13445	COG2166	iron-sulfur cluster assembly
AVL57_RS13460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVL57_RS13465	COG0719	Fe-S assembly protein
AVL57_RS13470	COG0396	ATPase activity
AVL57_RS13475	COG0719	Fe-S assembly protein
AVL57_RS13480	COG1104	cysteine desulfurase activity
AVL57_RS13495	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AVL57_RS13500	COG0483	inositol monophosphate 1-phosphatase activity
AVL57_RS13530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVL57_RS13535	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVL57_RS13540	COG1862	Preprotein translocase
AVL57_RS13545	COG0343	queuine tRNA-ribosyltransferase activity
AVL57_RS13560	COG3789	protein conserved in bacteria
AVL57_RS13565	COG1842	Phage shock protein A
AVL57_RS13590	COG0754	glutathionylspermidine amidase activity
AVL57_RS13605	COG2066	Belongs to the glutaminase family
AVL57_RS13610	COG1785	Belongs to the alkaline phosphatase family
AVL57_RS13615	COG0745	RESPONSE REGULATOR receiver
AVL57_RS13665	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AVL57_RS13670	COG1045	serine acetyltransferase
AVL57_RS13695	COG0438	transferase activity, transferring glycosyl groups
AVL57_RS13740	COG1216	Glycosyl transferase, family 2
AVL57_RS13740	COG0463	Glycosyl transferase, family 2
AVL57_RS13775	COG0489	protein tyrosine kinase activity
AVL57_RS13785	COG3409	Peptidoglycan-binding domain 1 protein
AVL57_RS13785	COG3267	Type II secretory pathway component ExeA
AVL57_RS13790	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AVL57_RS13790	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AVL57_RS13795	COG2827	Endonuclease containing a URI domain
AVL57_RS13815	COG1560	Kdo2-lipid A biosynthetic process
AVL57_RS13845	COG1960	acyl-CoA dehydrogenase activity
AVL57_RS13860	COG1435	thymidine kinase activity
AVL57_RS13870	COG1609	Transcriptional regulator
AVL57_RS13875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AVL57_RS13915	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AVL57_RS13920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVL57_RS13925	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AVL57_RS13930	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AVL57_RS13955	COG0515	serine threonine protein kinase
AVL57_RS13955	COG2815	serine threonine protein kinase
AVL57_RS13965	COG1982	Orn Lys Arg decarboxylase major
AVL57_RS13990	COG4774	siderophore transport
AVL57_RS14005	COG1028	Short-chain dehydrogenase reductase Sdr
AVL57_RS14020	COG1629	transport
AVL57_RS14020	COG4774	siderophore transport
AVL57_RS14025	COG4682	membrane
AVL57_RS14040	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AVL57_RS14045	COG0789	Transcriptional regulator
AVL57_RS14060	COG0189	ligase activity
AVL57_RS14115	COG1960	acyl-CoA dehydrogenase activity
AVL57_RS14145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AVL57_RS14155	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AVL57_RS14205	COG1607	acyl-coa hydrolase
AVL57_RS14210	COG0826	peptidase U32
AVL57_RS14275	COG0583	DNA-binding transcription factor activity
AVL57_RS14290	COG1028	Short-chain dehydrogenase reductase Sdr
AVL57_RS14295	COG1733	regulation of RNA biosynthetic process
AVL57_RS14310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AVL57_RS14345	COG1028	Short-chain dehydrogenase reductase Sdr
AVL57_RS14355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AVL57_RS14360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVL57_RS14375	COG0109	protoheme IX farnesyltransferase activity
AVL57_RS14390	COG0583	DNA-binding transcription factor activity
AVL57_RS14405	COG4221	oxidoreductase activity
AVL57_RS14410	COG0693	protein deglycase activity
AVL57_RS14460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AVL57_RS14465	COG1335	isochorismatase
AVL57_RS14470	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AVL57_RS14490	COG4771	TonB-dependent receptor
AVL57_RS14525	COG1566	PFAM secretion protein HlyD family protein
AVL57_RS14530	COG1846	Transcriptional regulator
AVL57_RS14540	COG1295	ribonuclease BN
AVL57_RS14550	COG0514	ATP-dependent DNA helicase (RecQ)
AVL57_RS14575	COG0583	DNA-binding transcription factor activity
AVL57_RS14585	COG0484	heat shock protein binding
AVL57_RS14590	COG1017	nitric oxide dioxygenase activity
AVL57_RS14590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVL57_RS14605	COG3604	Transcriptional regulator
AVL57_RS14630	COG2319	Wd-40 repeat
AVL57_RS14630	COG4249	Peptidase C14 caspase catalytic subunit p20
AVL57_RS14645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVL57_RS14665	COG1451	nucleotide metabolic process
AVL57_RS14680	COG0653	protein targeting
AVL57_RS14695	COG1757	Na H antiporter
AVL57_RS14715	COG2133	pyrroloquinoline quinone binding
AVL57_RS14725	COG0697	spore germination
AVL57_RS14730	COG0513	Belongs to the DEAD box helicase family
AVL57_RS14780	COG2814	Major facilitator Superfamily
AVL57_RS14790	COG0656	L-ascorbic acid biosynthetic process
AVL57_RS14840	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVL57_RS14840	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVL57_RS14855	COG0583	DNA-binding transcription factor activity
AVL57_RS14875	COG1621	beta-fructofuranosidase activity
AVL57_RS14880	COG0477	Major facilitator Superfamily
AVL57_RS14890	COG1629	transport
AVL57_RS14915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVL57_RS14920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVL57_RS14925	COG0006	proline dipeptidase activity
AVL57_RS14940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVL57_RS14955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AVL57_RS14960	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AVL57_RS14965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVL57_RS14985	COG3313	Fe-S protein
AVL57_RS15025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVL57_RS15030	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVL57_RS15035	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AVL57_RS15065	COG4969	Belongs to the N-Me-Phe pilin family
AVL57_RS15070	COG1459	type II secretion system
AVL57_RS15080	COG0237	dephospho-CoA kinase activity
AVL57_RS15080	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AVL57_RS15085	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AVL57_RS15090	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AVL57_RS15095	COG2988	succinylglutamate desuccinylase activity
AVL57_RS15100	COG0494	nUDIX hydrolase
AVL57_RS15110	COG0739	heme binding
AVL57_RS15115	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AVL57_RS15125	COG0849	cell division
AVL57_RS15130	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AVL57_RS15135	COG1181	Belongs to the D-alanine--D-alanine ligase family
AVL57_RS15140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AVL57_RS15150	COG0772	Belongs to the SEDS family
AVL57_RS15155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AVL57_RS15165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AVL57_RS15170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVL57_RS15175	COG0768	penicillin binding
AVL57_RS15180	COG3116	cell division
AVL57_RS15190	COG2001	Belongs to the MraZ family
AVL57_RS15230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AVL57_RS15230	COG0678	peroxiredoxin activity
AVL57_RS15245	COG2204	response regulator
AVL57_RS15250	COG0784	Response regulator, receiver
AVL57_RS15250	COG2198	Histidine kinase
AVL57_RS15250	COG5002	protein histidine kinase activity
AVL57_RS15270	COG0668	transmembrane transport
AVL57_RS15275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AVL57_RS15280	COG0189	ligase activity
AVL57_RS15285	COG1678	Uncharacterized ACR, COG1678
AVL57_RS15290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AVL57_RS15310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AVL57_RS15315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AVL57_RS15320	COG0762	integral membrane protein
AVL57_RS15335	COG1902	pentaerythritol trinitrate reductase activity
AVL57_RS15335	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVL57_RS15350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVL57_RS15355	COG0625	glutathione transferase activity
AVL57_RS15385	COG0083	homoserine kinase activity
AVL57_RS15395	COG0583	DNA-binding transcription factor activity
AVL57_RS15405	COG2197	response regulator
AVL57_RS15410	COG4585	Histidine kinase
AVL57_RS15430	COG0640	Transcriptional regulator
AVL57_RS15440	COG0431	NADPH-dependent FMN reductase
AVL57_RS15445	COG0798	PFAM Bile acid sodium symporter
AVL57_RS15450	COG2201	protein-glutamate methylesterase activity
AVL57_RS15455	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AVL57_RS15460	COG0745	RESPONSE REGULATOR receiver
AVL57_RS15465	COG5002	protein histidine kinase activity
AVL57_RS15490	COG1748	Saccharopine dehydrogenase
AVL57_RS15505	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AVL57_RS15510	COG3107	peptidoglycan biosynthetic process
AVL57_RS15515	COG0792	nuclease activity
AVL57_RS15525	COG2823	Periplasmic or secreted lipoprotein
AVL57_RS15570	COG4585	Histidine kinase
AVL57_RS15575	COG2197	response regulator
AVL57_RS15580	COG4771	TonB-dependent receptor
AVL57_RS15590	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AVL57_RS15595	COG0372	Belongs to the citrate synthase family
AVL57_RS15605	COG2828	Protein conserved in bacteria
AVL57_RS15610	COG3706	GGDEF domain
AVL57_RS15635	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AVL57_RS15655	COG5002	protein histidine kinase activity
AVL57_RS15655	COG0784	Response regulator, receiver
AVL57_RS15655	COG2198	Histidine kinase
AVL57_RS15660	COG0069	glutamate synthase activity
AVL57_RS15660	COG0067	glutamate synthase
AVL57_RS15660	COG0070	glutamate synthase
AVL57_RS15665	COG0493	'glutamate synthase
AVL57_RS15675	COG1476	TRANSCRIPTIONal
AVL57_RS15715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AVL57_RS15725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVL57_RS15730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVL57_RS15745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AVL57_RS15750	COG0739	heme binding
AVL57_RS15755	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AVL57_RS15765	COG0738	Major facilitator superfamily
AVL57_RS15770	COG3659	wide pore channel activity
AVL57_RS15775	COG1902	pentaerythritol trinitrate reductase activity
AVL57_RS15785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVL57_RS15790	COG0625	glutathione transferase activity
AVL57_RS15810	COG2894	cell division
AVL57_RS15815	COG0850	regulation of cytokinetic process
AVL57_RS15840	COG1981	membrane
AVL57_RS15855	COG1914	H( )-stimulated, divalent metal cation uptake system
AVL57_RS15860	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AVL57_RS15875	COG1217	gtp-binding protein TYPA
AVL57_RS15880	COG0174	glutamine synthetase
AVL57_RS15890	COG3852	Histidine kinase
AVL57_RS15900	COG3437	response regulator, receiver
AVL57_RS15920	COG3706	GGDEF domain
AVL57_RS15935	COG0525	valine-tRNA ligase activity
AVL57_RS15940	COG2927	DNA polymerase III (CHI subunit)
AVL57_RS15945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AVL57_RS15950	COG0795	lipopolysaccharide-transporting ATPase activity
AVL57_RS15955	COG0795	lipopolysaccharide-transporting ATPase activity
AVL57_RS16020	COG1082	Xylose isomerase domain protein TIM barrel
AVL57_RS16105	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AVL57_RS16175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVL57_RS16185	COG0395	ABC-type sugar transport system, permease component
AVL57_RS16205	COG3706	GGDEF domain
AVL57_RS16210	COG3706	GGDEF domain
AVL57_RS16250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AVL57_RS16255	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AVL57_RS16260	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AVL57_RS16270	COG0535	radical SAM domain protein
AVL57_RS16300	COG0784	Response regulator, receiver
AVL57_RS16300	COG2205	protein histidine kinase activity
AVL57_RS16310	COG3901	Regulator of nitric oxide reductase transcription
AVL57_RS16310	COG0348	domain, Protein
AVL57_RS16320	COG2197	response regulator
AVL57_RS16325	COG4585	Histidine kinase
AVL57_RS16355	COG4771	TonB-dependent receptor
AVL57_RS16360	COG1858	cytochrome C peroxidase
AVL57_RS16390	COG1028	Short-chain dehydrogenase reductase Sdr
AVL57_RS16400	COG1917	Cupin 2, conserved barrel domain protein
AVL57_RS16405	COG2271	Major facilitator Superfamily
AVL57_RS16425	COG1716	ATPase activity
AVL57_RS16460	COG1357	PFAM Pentapeptide repeats (8 copies)
AVL57_RS16460	COG0515	serine threonine protein kinase
AVL57_RS16475	COG0842	Transport permease protein
AVL57_RS16475	COG1131	(ABC) transporter
AVL57_RS16475	COG1716	ATPase activity
AVL57_RS16480	COG0513	Belongs to the DEAD box helicase family
AVL57_RS16485	COG0800	Aldolase
AVL57_RS16490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVL57_RS16495	COG2186	Transcriptional regulator
AVL57_RS16505	COG3264	Mechanosensitive ion channel
AVL57_RS16505	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AVL57_RS16540	COG3568	Endonuclease Exonuclease Phosphatase
AVL57_RS16555	COG0730	response to heat
AVL57_RS16560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVL57_RS16575	COG4191	Histidine kinase
AVL57_RS16585	COG0417	DNA replication proofreading
AVL57_RS16635	COG1309	transcriptional regulator
AVL57_RS16650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVL57_RS16660	COG1573	uracil-dna glycosylase
AVL57_RS16665	COG3300	MHYT domain
AVL57_RS16665	COG5001	Diguanylate cyclase
AVL57_RS16685	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AVL57_RS16690	COG4771	TonB-dependent receptor
AVL57_RS16715	COG1842	Phage shock protein A
AVL57_RS16725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AVL57_RS16750	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AVL57_RS16755	COG0204	Acyl-transferase
AVL57_RS16760	COG0204	Acyl-transferase
AVL57_RS16765	COG0668	transmembrane transport
AVL57_RS16780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVL57_RS16785	COG0733	neurotransmitter:sodium symporter activity
AVL57_RS16800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVL57_RS16825	COG0848	biopolymer transport protein
AVL57_RS16835	COG0457	Tetratricopeptide repeat
AVL57_RS16865	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AVL57_RS16870	COG0702	epimerase
AVL57_RS16885	COG5001	Diguanylate cyclase
AVL57_RS16885	COG5002	protein histidine kinase activity
AVL57_RS16895	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AVL57_RS16900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVL57_RS16910	COG0583	DNA-binding transcription factor activity
AVL57_RS16915	COG0121	glutamine amidotransferase
AVL57_RS16930	COG1522	sequence-specific DNA binding
AVL57_RS16945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVL57_RS16955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AVL57_RS16965	COG1477	protein flavinylation
AVL57_RS16970	COG2871	sodium ion transport
AVL57_RS16975	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AVL57_RS16980	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AVL57_RS16985	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AVL57_RS16990	COG1805	sodium ion transport
AVL57_RS16995	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AVL57_RS17000	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AVL57_RS17005	COG0545	Peptidyl-prolyl cis-trans isomerase
AVL57_RS17010	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AVL57_RS17020	COG0039	L-malate dehydrogenase activity
AVL57_RS17025	COG1438	arginine binding
AVL57_RS17055	COG0572	uridine kinase
AVL57_RS17060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AVL57_RS17070	COG0457	Tetratricopeptide repeat
AVL57_RS17075	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AVL57_RS17095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AVL57_RS17095	COG0517	IMP dehydrogenase activity
AVL57_RS17100	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVL57_RS17120	COG0189	ligase activity
AVL57_RS17130	COG4067	protein conserved in archaea
AVL57_RS17130	COG0189	ligase activity
AVL57_RS17145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVL57_RS17160	COG1283	sodium-dependent phosphate transmembrane transporter activity
AVL57_RS17165	COG0667	Aldo Keto reductase
AVL57_RS17180	COG0753	catalase activity
AVL57_RS17230	COG0583	DNA-binding transcription factor activity
AVL57_RS17290	COG1216	Glycosyl transferase, family 2
AVL57_RS17290	COG0438	transferase activity, transferring glycosyl groups
AVL57_RS17315	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AVL57_RS17330	COG3119	arylsulfatase activity
AVL57_RS17345	COG1216	Glycosyl transferase, family 2
AVL57_RS17345	COG0438	transferase activity, transferring glycosyl groups
AVL57_RS17350	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AVL57_RS17350	COG0662	Cupin 2, conserved barrel domain protein
AVL57_RS17360	COG0202	RNA polymerase activity
AVL57_RS17380	COG0201	protein transport
AVL57_RS17400	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AVL57_RS17435	COG5002	protein histidine kinase activity
AVL57_RS17435	COG0784	Response regulator, receiver
AVL57_RS17450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVL57_RS17455	COG0557	exoribonuclease II activity
AVL57_RS17470	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AVL57_RS17485	COG0543	2 iron, 2 sulfur cluster binding
AVL57_RS17490	COG2234	aminopeptidase activity
AVL57_RS17510	COG1271	oxidase subunit
AVL57_RS17515	COG1294	oxidase, subunit
AVL57_RS17520	COG0840	transmembrane signaling receptor activity
AVL57_RS17525	COG1522	sequence-specific DNA binding
AVL57_RS17540	COG1278	Cold shock
AVL57_RS17545	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AVL57_RS17565	COG0339	signal peptide processing
AVL57_RS17570	COG2201	protein-glutamate methylesterase activity
AVL57_RS17590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVL57_RS17595	COG0243	molybdopterin cofactor binding
AVL57_RS17600	COG0793	Belongs to the peptidase S41A family
AVL57_RS17600	COG4946	Tricorn protease homolog
AVL57_RS17640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AVL57_RS17645	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AVL57_RS17650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AVL57_RS17665	COG0281	malic enzyme
AVL57_RS17670	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AVL57_RS17675	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AVL57_RS17705	COG0456	acetyltransferase
AVL57_RS17715	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AVL57_RS17720	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AVL57_RS17725	COG2177	Part of the ABC transporter FtsEX involved in
AVL57_RS17730	COG2884	Cell division ATP-binding protein ftsE
AVL57_RS17735	COG0552	protein localization to endoplasmic reticulum
AVL57_RS17740	COG0742	ribosomal rna small subunit methyltransferase
AVL57_RS17750	COG2095	MarC family integral membrane protein
AVL57_RS17770	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AVL57_RS17775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVL57_RS17785	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AVL57_RS17800	COG0076	glutamate decarboxylase activity
AVL57_RS17805	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AVL57_RS17815	COG0842	Transport permease protein
AVL57_RS17820	COG1131	(ABC) transporter
AVL57_RS17825	COG0745	RESPONSE REGULATOR receiver
AVL57_RS17830	COG2205	protein histidine kinase activity
AVL57_RS17835	COG4774	siderophore transport
AVL57_RS17855	COG1253	flavin adenine dinucleotide binding
AVL57_RS17860	COG0701	Predicted permease
AVL57_RS17865	COG1966	Carbon starvation protein
AVL57_RS17880	COG0657	acetylesterase activity
AVL57_RS17920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AVL57_RS17925	COG0049	tRNA binding
AVL57_RS17930	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AVL57_RS17935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AVL57_RS17940	COG0085	RNA polymerase activity
AVL57_RS17945	COG0222	ribosome binding
AVL57_RS17950	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AVL57_RS17955	COG0081	regulation of translation
AVL57_RS17960	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AVL57_RS17965	COG0250	Participates in transcription elongation, termination and antitermination
AVL57_RS17970	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AVL57_RS17980	COG1132	(ABC) transporter
AVL57_RS17985	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AVL57_RS17990	COG3590	peptidase
AVL57_RS18000	COG0513	Belongs to the DEAD box helicase family
AVL57_RS18005	COG0418	dihydroorotase activity
AVL57_RS18015	COG3040	lipid binding
AVL57_RS18020	COG4989	oxidoreductase activity
AVL57_RS18025	COG0346	lactoylglutathione lyase activity
AVL57_RS18040	COG0302	gtp cyclohydrolase
AVL57_RS18060	COG2957	Belongs to the agmatine deiminase family
AVL57_RS18065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVL57_RS18080	COG3306	glycosyltransferase involved in LPS biosynthesis
AVL57_RS18085	COG1201	RNA secondary structure unwinding
AVL57_RS18095	COG1793	dna ligase
AVL57_RS18105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVL57_RS18120	COG0625	glutathione transferase activity
AVL57_RS18135	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AVL57_RS18140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVL57_RS18150	COG1012	belongs to the aldehyde dehydrogenase family
AVL57_RS18165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVL57_RS18170	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AVL57_RS18175	COG0330	HflC and HflK could
AVL57_RS18180	COG0330	HflC and HflK could
AVL57_RS18185	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AVL57_RS18190	COG1923	regulation of RNA biosynthetic process
AVL57_RS18195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AVL57_RS18210	COG0802	atpase or kinase
AVL57_RS18215	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AVL57_RS18215	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AVL57_RS18220	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AVL57_RS18235	COG2816	NAD+ diphosphatase activity
AVL57_RS18240	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AVL57_RS18245	COG0735	belongs to the Fur family
AVL57_RS18265	COG0305	Participates in initiation and elongation during chromosome replication
AVL57_RS18290	COG2258	MOSC domain
AVL57_RS18320	COG5002	protein histidine kinase activity
AVL57_RS18335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVL57_RS18335	COG4191	Histidine kinase
AVL57_RS18345	COG1609	Transcriptional regulator
AVL57_RS18350	COG2211	Major facilitator Superfamily
AVL57_RS18355	COG2723	6-phospho-beta-galactosidase activity
AVL57_RS18365	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AVL57_RS18370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVL57_RS18375	COG4558	Periplasmic binding protein
AVL57_RS18385	COG4206	TonB-dependent receptor
AVL57_RS18395	COG1472	Belongs to the glycosyl hydrolase 3 family
AVL57_RS18410	COG2855	membrane
AVL57_RS18415	COG2175	clavaminate synthase activity
AVL57_RS18420	COG0656	L-ascorbic acid biosynthetic process
AVL57_RS18425	COG2188	Transcriptional regulator
AVL57_RS18440	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVL57_RS18445	COG1230	cation diffusion facilitator family transporter
AVL57_RS18480	COG4771	TonB-dependent receptor
AVL57_RS18485	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AVL57_RS18490	COG4988	ABC transporter
AVL57_RS18500	COG1294	oxidase, subunit
AVL57_RS18515	COG2204	response regulator
AVL57_RS18550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AVL57_RS18575	COG4319	ketosteroid isomerase
AVL57_RS18615	COG3237	CsbD-like
AVL57_RS18635	COG1404	Belongs to the peptidase S8 family
AVL57_RS18660	COG2267	carboxylic ester hydrolase activity
AVL57_RS18685	COG3038	cytochrome b561
AVL57_RS18690	COG2353	YceI-like domain
AVL57_RS18695	COG1252	NADH dehydrogenase
AVL57_RS18720	COG2067	long-chain fatty acid transport protein
AVL57_RS18725	COG2130	NADP-dependent
AVL57_RS18730	COG5001	Diguanylate cyclase
AVL57_RS18730	COG3706	GGDEF domain
AVL57_RS18730	COG2203	Gaf domain
AVL57_RS18730	COG4251	negative regulation of phosphorylation
AVL57_RS18750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL57_RS18760	COG4181	ATPase activity
AVL57_RS18780	COG0523	cobalamin synthesis protein
AVL57_RS18795	COG4771	TonB-dependent receptor
AVL57_RS18815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AVL57_RS18820	COG1349	DNA-binding transcription factor activity
AVL57_RS18835	COG0697	spore germination
AVL57_RS18840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AVL57_RS18845	COG4977	sequence-specific DNA binding
AVL57_RS18855	COG1166	arginine decarboxylase activity
AVL57_RS18865	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AVL57_RS18885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVL57_RS18915	COG4232	protein-disulfide reductase activity
AVL57_RS18920	COG0739	heme binding
AVL57_RS18925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AVL57_RS18930	COG0511	ligase activity, forming carbon-carbon bonds
AVL57_RS18935	COG0439	Biotin carboxylase
AVL57_RS18955	COG2176	DNA-directed DNA polymerase activity
AVL57_RS18975	COG0154	amidase activity
AVL57_RS18990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AVL57_RS18995	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AVL57_RS19010	COG0151	Belongs to the GarS family
AVL57_RS19020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVL57_RS19030	COG3954	Phosphoribulokinase
AVL57_RS19035	COG2233	PERMEase
AVL57_RS19065	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AVL57_RS19070	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AVL57_RS19080	COG3031	protein transport across the cell outer membrane
AVL57_RS19090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AVL57_RS19095	COG1459	type II secretion system
AVL57_RS19100	COG2165	general secretion pathway protein
AVL57_RS19110	COG2165	general secretion pathway protein
AVL57_RS19115	COG4795	General secretion pathway protein
AVL57_RS19130	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AVL57_RS19140	COG1234	tRNA 3'-trailer cleavage
AVL57_RS19145	COG1012	belongs to the aldehyde dehydrogenase family
AVL57_RS19155	COG1011	Hydrolase
AVL57_RS19160	COG0494	nUDIX hydrolase
AVL57_RS19165	COG1218	3'(2'),5'-bisphosphate nucleotidase
AVL57_RS19175	COG2943	transferase activity, transferring hexosyl groups
AVL57_RS19180	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AVL57_RS19190	COG3089	Belongs to the UPF0270 family
AVL57_RS19195	COG0429	hydrolase of the alpha beta-hydrolase fold
AVL57_RS19205	COG0488	(ABC) transporter
AVL57_RS19230	COG0545	Peptidyl-prolyl cis-trans isomerase
AVL57_RS19240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AVL57_RS19245	COG2183	response to ionizing radiation
AVL57_RS19260	COG0596	Alpha beta hydrolase
AVL57_RS19265	COG1040	competence protein
AVL57_RS19285	COG1794	racemase activity, acting on amino acids and derivatives
AVL57_RS19300	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AVL57_RS19305	COG0534	Mate efflux family protein
AVL57_RS19320	COG1999	signal sequence binding
AVL57_RS19325	COG0109	protoheme IX farnesyltransferase activity
AVL57_RS19330	COG1612	heme a metabolic process
AVL57_RS19355	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AVL57_RS19360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVL57_RS19365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AVL57_RS19365	COG1565	acr, cog1565
AVL57_RS19395	COG0129	dihydroxy-acid dehydratase activity
AVL57_RS19410	COG0606	chelatase, subunit chli
AVL57_RS19425	COG2814	Major facilitator Superfamily
AVL57_RS19435	COG0729	surface antigen
AVL57_RS19440	COG2911	Protein conserved in bacteria
AVL57_RS19465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVL57_RS19475	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AVL57_RS19495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AVL57_RS19545	COG0425	Belongs to the sulfur carrier protein TusA family
AVL57_RS19560	COG1561	YicC-like family, N-terminal region
AVL57_RS19590	COG2723	6-phospho-beta-galactosidase activity
AVL57_RS19595	COG2211	Major facilitator Superfamily
AVL57_RS19600	COG1609	Transcriptional regulator
AVL57_RS19615	COG2199	diguanylate cyclase activity
AVL57_RS19615	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AVL57_RS19645	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AVL57_RS19665	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AVL57_RS19670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AVL57_RS19690	COG1475	DNA binding
AVL57_RS19695	COG1192	Involved in chromosome partitioning
AVL57_RS19720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AVL57_RS19725	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AVL57_RS19735	COG0706	membrane insertase activity
AVL57_RS19740	COG0594	ribonuclease P activity
AVL57_RS19745	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AVL57_RS19755	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AVL57_RS19870	COG0569	domain protein
AVL57_RS19900	COG0009	L-threonylcarbamoyladenylate synthase
AVL57_RS20280	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVL57_RS20280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AVL57_RS20345	COG1012	belongs to the aldehyde dehydrogenase family
AVL57_RS20350	COG1012	belongs to the aldehyde dehydrogenase family
AVL57_RS20365	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AVL57_RS20825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family