locus-tag	class	description
A6K25_RS00015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6K25_RS00020	COG1138	Cytochrome C-type biogenesis protein
A6K25_RS00030	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6K25_RS00035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6K25_RS00040	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6K25_RS00045	COG4133	protoheme IX ABC transporter activity
A6K25_RS00065	COG1668	transmembrane transport
A6K25_RS00070	COG4555	ABC transporter
A6K25_RS00085	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6K25_RS00115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6K25_RS00120	COG0473	3-isopropylmalate dehydrogenase activity
A6K25_RS00130	COG0066	3-isopropylmalate dehydratase activity
A6K25_RS00135	COG0784	Response regulator, receiver
A6K25_RS00135	COG3437	response regulator, receiver
A6K25_RS00145	COG3267	Type II secretory pathway component ExeA
A6K25_RS00145	COG3409	Peptidoglycan-binding domain 1 protein
A6K25_RS00155	COG0513	Belongs to the DEAD box helicase family
A6K25_RS00165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6K25_RS00195	COG1346	cytolysis
A6K25_RS00265	COG4667	esterase of the alpha-beta hydrolase superfamily
A6K25_RS00300	COG0488	(ABC) transporter
A6K25_RS00310	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6K25_RS00315	COG2971	BadF BadG BcrA BcrD
A6K25_RS00325	COG3706	GGDEF domain
A6K25_RS00330	COG0419	ATPase involved in DNA repair
A6K25_RS00335	COG0420	3'-5' exonuclease activity
A6K25_RS00345	COG1739	Uncharacterized protein family UPF0029
A6K25_RS00360	COG1764	response to oxidative stress
A6K25_RS00365	COG1846	Transcriptional regulator
A6K25_RS00370	COG1472	Belongs to the glycosyl hydrolase 3 family
A6K25_RS00385	COG2207	Transcriptional regulator
A6K25_RS00390	COG3291	Pkd domain containing protein
A6K25_RS00390	COG4447	cellulose binding
A6K25_RS00390	COG5520	Belongs to the glycosyl hydrolase 30 family
A6K25_RS00395	COG2115	Belongs to the xylose isomerase family
A6K25_RS00400	COG1070	Carbohydrate kinase
A6K25_RS00405	COG1609	Transcriptional regulator
A6K25_RS00405	COG2207	Transcriptional regulator
A6K25_RS00410	COG0477	Major facilitator Superfamily
A6K25_RS00430	COG1272	protein, Hemolysin III
A6K25_RS00455	COG0583	DNA-binding transcription factor activity
A6K25_RS00465	COG0306	phosphate transporter
A6K25_RS00475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6K25_RS00480	COG0581	inorganic phosphate transmembrane transporter activity
A6K25_RS00485	COG0573	inorganic phosphate transmembrane transporter activity
A6K25_RS00495	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6K25_RS00500	COG0248	Ppx GppA phosphatase
A6K25_RS00505	COG4946	Tricorn protease homolog
A6K25_RS00505	COG0823	Involved in the tonB-independent uptake of proteins
A6K25_RS00505	COG1506	peptidase
A6K25_RS00510	COG3588	fructose-bisphosphate aldolase
A6K25_RS00515	COG0126	phosphoglycerate kinase activity
A6K25_RS00525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6K25_RS00550	COG1979	alcohol dehydrogenase
A6K25_RS00555	COG2207	Transcriptional regulator
A6K25_RS00565	COG0784	Response regulator, receiver
A6K25_RS00565	COG2205	protein histidine kinase activity
A6K25_RS00570	COG3300	MHYT domain
A6K25_RS00570	COG5001	Diguanylate cyclase
A6K25_RS00585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6K25_RS00600	COG2207	Transcriptional regulator
A6K25_RS00615	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6K25_RS00625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6K25_RS00630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6K25_RS00640	COG5007	Belongs to the BolA IbaG family
A6K25_RS00650	COG2854	intermembrane phospholipid transfer
A6K25_RS00655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6K25_RS00660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6K25_RS00665	COG1127	ABC transporter
A6K25_RS00680	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6K25_RS00695	COG1137	ATPase activity
A6K25_RS00720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6K25_RS00725	COG2239	Acts as a magnesium transporter
A6K25_RS00740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6K25_RS00740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6K25_RS00745	COG2969	positive regulation of protein catabolic process
A6K25_RS00750	COG0625	glutathione transferase activity
A6K25_RS00755	COG2857	Cytochrome c1
A6K25_RS00760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6K25_RS00765	COG0723	plastoquinol--plastocyanin reductase activity
A6K25_RS00770	COG1473	amidohydrolase
A6K25_RS00780	COG4206	TonB-dependent receptor
A6K25_RS00790	COG1595	DNA-templated transcription, initiation
A6K25_RS00795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6K25_RS00815	COG3956	TIGRFAM MazG family protein
A6K25_RS00820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6K25_RS00825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6K25_RS00835	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6K25_RS00855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6K25_RS00865	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6K25_RS00870	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6K25_RS00875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6K25_RS00880	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6K25_RS00895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6K25_RS00900	COG0840	transmembrane signaling receptor activity
A6K25_RS00905	COG0527	aspartate kinase activity
A6K25_RS00925	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6K25_RS00930	COG2133	pyrroloquinoline quinone binding
A6K25_RS00950	COG3437	response regulator, receiver
A6K25_RS00955	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6K25_RS00965	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A6K25_RS00970	COG0848	biopolymer transport protein
A6K25_RS00975	COG0811	peptide transport
A6K25_RS00980	COG0811	peptide transport
A6K25_RS01010	COG5002	protein histidine kinase activity
A6K25_RS01015	COG0745	RESPONSE REGULATOR receiver
A6K25_RS01020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6K25_RS01020	COG4191	Histidine kinase
A6K25_RS01025	COG2974	May be involved in recombination
A6K25_RS01030	COG1396	sequence-specific DNA binding
A6K25_RS01035	COG3135	benzoate transporter
A6K25_RS01050	COG0537	adenosine 5'-monophosphoramidase activity
A6K25_RS01065	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6K25_RS01070	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6K25_RS01090	COG1610	YqeY-like protein
A6K25_RS01095	COG0358	DNA primase activity
A6K25_RS01120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6K25_RS01125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6K25_RS01140	COG4948	Mandelate Racemase Muconate Lactonizing
A6K25_RS01160	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_RS01165	COG1960	acyl-CoA dehydrogenase activity
A6K25_RS01180	COG0348	domain, Protein
A6K25_RS01185	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6K25_RS01190	COG4206	TonB-dependent receptor
A6K25_RS01195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6K25_RS01210	COG1116	anion transmembrane transporter activity
A6K25_RS01215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6K25_RS01220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6K25_RS01220	COG1116	anion transmembrane transporter activity
A6K25_RS01235	COG1648	precorrin-2 dehydrogenase activity
A6K25_RS01235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6K25_RS01240	COG0243	molybdopterin cofactor binding
A6K25_RS01245	COG2146	nitrite reductase [NAD(P)H] activity
A6K25_RS01250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6K25_RS01255	COG0659	secondary active sulfate transmembrane transporter activity
A6K25_RS01265	COG3707	response regulator
A6K25_RS01275	COG0671	phosphoesterase, PA-phosphatase related
A6K25_RS01280	COG0271	Belongs to the BolA IbaG family
A6K25_RS01295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6K25_RS01320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6K25_RS01325	COG1509	lysine 2,3-aminomutase activity
A6K25_RS01345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6K25_RS01350	COG4251	negative regulation of phosphorylation
A6K25_RS01365	COG3150	esterase
A6K25_RS01380	COG0494	nUDIX hydrolase
A6K25_RS01385	COG1538	Outer membrane efflux protein
A6K25_RS01405	COG1648	precorrin-2 dehydrogenase activity
A6K25_RS01405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6K25_RS01415	COG3119	arylsulfatase activity
A6K25_RS01420	COG3119	arylsulfatase activity
A6K25_RS01455	COG3119	arylsulfatase activity
A6K25_RS01550	COG2124	cytochrome p450
A6K25_RS01565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6K25_RS01570	COG2814	Major facilitator Superfamily
A6K25_RS01575	COG4948	Mandelate Racemase Muconate Lactonizing
A6K25_RS01580	COG1063	alcohol dehydrogenase
A6K25_RS01585	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_RS01590	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_RS01595	COG3119	arylsulfatase activity
A6K25_RS01600	COG1802	Transcriptional regulator
A6K25_RS01610	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A6K25_RS01620	COG0564	pseudouridine synthase activity
A6K25_RS01640	COG0784	Response regulator, receiver
A6K25_RS01640	COG5002	protein histidine kinase activity
A6K25_RS01645	COG3706	GGDEF domain
A6K25_RS01650	COG2201	protein-glutamate methylesterase activity
A6K25_RS01655	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6K25_RS01660	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6K25_RS01665	COG0730	response to heat
A6K25_RS01670	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
A6K25_RS01675	COG0494	nUDIX hydrolase
A6K25_RS01690	COG3025	triphosphatase activity
A6K25_RS01695	COG4991	sh3 domain protein
A6K25_RS01710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6K25_RS01725	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A6K25_RS01725	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A6K25_RS01725	COG0506	proline dehydrogenase activity
A6K25_RS01730	COG0840	transmembrane signaling receptor activity
A6K25_RS01740	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A6K25_RS01755	COG0585	pseudouridine synthase activity
A6K25_RS01760	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6K25_RS01770	COG1238	metal cluster binding
A6K25_RS01830	COG0142	geranyltranstransferase activity
A6K25_RS01840	COG0006	proline dipeptidase activity
A6K25_RS01850	COG1024	Enoyl-CoA hydratase
A6K25_RS01850	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6K25_RS01855	COG0183	Belongs to the thiolase family
A6K25_RS01925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6K25_RS01935	COG3547	Transposase (IS116 IS110 IS902 family)
A6K25_RS01955	COG0666	response to abiotic stimulus
A6K25_RS01965	COG3547	Transposase (IS116 IS110 IS902 family)
A6K25_RS01980	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
A6K25_RS02035	COG2161	toxin-antitoxin pair type II binding
A6K25_RS02040	COG4115	mRNA cleavage
A6K25_RS02100	COG0840	transmembrane signaling receptor activity
A6K25_RS02115	COG0346	lactoylglutathione lyase activity
A6K25_RS02135	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6K25_RS02140	COG3876	Protein conserved in bacteria
A6K25_RS02160	COG1757	Na H antiporter
A6K25_RS02180	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_RS02190	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A6K25_RS02200	COG3118	belongs to the thioredoxin family
A6K25_RS02210	COG2133	pyrroloquinoline quinone binding
A6K25_RS02215	COG0783	Belongs to the Dps family
A6K25_RS02230	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6K25_RS02235	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6K25_RS02240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6K25_RS02245	COG0784	Response regulator, receiver
A6K25_RS02245	COG2205	protein histidine kinase activity
A6K25_RS02250	COG1473	amidohydrolase
A6K25_RS02255	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6K25_RS02260	COG3118	belongs to the thioredoxin family
A6K25_RS02265	COG0513	Belongs to the DEAD box helicase family
A6K25_RS02270	COG0248	Ppx GppA phosphatase
A6K25_RS02295	COG0805	protein transport
A6K25_RS02300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6K25_RS02320	COG0028	Belongs to the TPP enzyme family
A6K25_RS02335	COG0457	Tetratricopeptide repeat
A6K25_RS02355	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A6K25_RS02360	COG1162	GTPase activity
A6K25_RS02375	COG0584	glycerophosphoryl diester phosphodiesterase
A6K25_RS02385	COG2861	carbohydrate metabolic process
A6K25_RS02395	COG4942	peptidase
A6K25_RS02405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6K25_RS02420	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6K25_RS02430	COG2205	protein histidine kinase activity
A6K25_RS02435	COG0745	RESPONSE REGULATOR receiver
A6K25_RS02450	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6K25_RS02460	COG1803	Methylglyoxal synthase
A6K25_RS02475	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6K25_RS02480	COG0137	argininosuccinate synthase activity
A6K25_RS02490	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6K25_RS02490	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6K25_RS02495	COG5001	Diguanylate cyclase
A6K25_RS02495	COG3300	MHYT domain
A6K25_RS02530	COG0625	glutathione transferase activity
A6K25_RS02535	COG0281	malic enzyme
A6K25_RS02540	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6K25_RS02575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6K25_RS02585	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A6K25_RS02605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6K25_RS02610	COG0180	Tryptophanyl-tRNA synthetase
A6K25_RS02615	COG0512	Glutamine amidotransferase of anthranilate synthase
A6K25_RS02625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6K25_RS02635	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_RS02660	COG3850	Histidine kinase
A6K25_RS02660	COG4999	Histidine kinase
A6K25_RS02660	COG2205	protein histidine kinase activity
A6K25_RS02660	COG3437	response regulator, receiver
A6K25_RS02685	COG0540	Belongs to the ATCase OTCase family
A6K25_RS02700	COG2837	iron assimilation
A6K25_RS02705	COG0405	Gamma-glutamyltransferase
A6K25_RS02710	COG0004	ammonium transporteR
A6K25_RS02735	COG2354	Protein conserved in bacteria
A6K25_RS02745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6K25_RS02755	COG2951	lytic endotransglycosylase activity
A6K25_RS02760	COG1643	Atp-dependent helicase
A6K25_RS02770	COG0788	formyltetrahydrofolate deformylase activity
A6K25_RS02780	COG0339	signal peptide processing
A6K25_RS02805	COG1519	Transferase
A6K25_RS02810	COG0859	PFAM glycosyl transferase family 9
A6K25_RS02815	COG0438	transferase activity, transferring glycosyl groups
A6K25_RS02820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6K25_RS02835	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6K25_RS02845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6K25_RS02855	COG0089	rRNA binding
A6K25_RS02870	COG0051	transcription antitermination factor activity, RNA binding
A6K25_RS02875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6K25_RS02895	COG1454	alcohol dehydrogenase
A6K25_RS02940	COG0673	inositol 2-dehydrogenase activity
A6K25_RS02945	COG1609	Transcriptional regulator
A6K25_RS03005	COG0501	Belongs to the peptidase M48B family
A6K25_RS03020	COG2201	protein-glutamate methylesterase activity
A6K25_RS03025	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A6K25_RS03040	COG0835	chemotaxis
A6K25_RS03045	COG2198	Histidine kinase
A6K25_RS03045	COG0643	Histidine kinase
A6K25_RS03050	COG0745	RESPONSE REGULATOR receiver
A6K25_RS03105	COG1194	a g-specific adenine glycosylase
A6K25_RS03115	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6K25_RS03125	COG0297	glycogen (starch) synthase activity
A6K25_RS03130	COG4191	Histidine kinase
A6K25_RS03130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6K25_RS03135	COG0745	RESPONSE REGULATOR receiver
A6K25_RS03150	COG0312	modulator of DNA gyrase
A6K25_RS03155	COG3028	Belongs to the UPF0307 family
A6K25_RS03165	COG0312	modulator of DNA gyrase
A6K25_RS03170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6K25_RS03180	COG1530	ribonuclease E activity
A6K25_RS03190	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A6K25_RS03195	COG1792	Involved in formation and maintenance of cell shape
A6K25_RS03200	COG1077	Cell shape determining protein MreB Mrl
A6K25_RS03225	COG2165	general secretion pathway protein
A6K25_RS03230	COG2165	general secretion pathway protein
A6K25_RS03240	COG1459	type II secretion system
A6K25_RS03245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6K25_RS03255	COG3267	Type II secretory pathway component ExeA
A6K25_RS03255	COG3409	Peptidoglycan-binding domain 1 protein
A6K25_RS03295	COG1349	DNA-binding transcription factor activity
A6K25_RS03310	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6K25_RS03350	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6K25_RS03360	COG0745	RESPONSE REGULATOR receiver
A6K25_RS03375	COG4615	Cyclic peptide transporter
A6K25_RS03395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6K25_RS03405	COG3710	Transcriptional regulator
A6K25_RS03445	COG0629	single-stranded DNA binding
A6K25_RS03455	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6K25_RS03460	COG1085	galactose-1-phosphate uridylyltransferase
A6K25_RS03480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6K25_RS03485	COG2814	Major facilitator Superfamily
A6K25_RS03490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6K25_RS03515	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6K25_RS03525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6K25_RS03530	COG0163	prenyltransferase activity
A6K25_RS03560	COG0019	diaminopimelate decarboxylase activity
A6K25_RS03565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6K25_RS03580	COG1011	Hydrolase
A6K25_RS03605	COG2239	Acts as a magnesium transporter
A6K25_RS03610	COG2050	protein possibly involved in aromatic compounds catabolism
A6K25_RS03615	COG0514	ATP-dependent DNA helicase (RecQ)
A6K25_RS03625	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6K25_RS03635	COG5001	Diguanylate cyclase
A6K25_RS03635	COG5002	protein histidine kinase activity
A6K25_RS03640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6K25_RS03645	COG3064	Membrane
A6K25_RS03655	COG0840	transmembrane signaling receptor activity
A6K25_RS03665	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6K25_RS03670	COG0427	acetyl-CoA hydrolase
A6K25_RS03680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6K25_RS03685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6K25_RS03710	COG0583	DNA-binding transcription factor activity
A6K25_RS03720	COG5002	protein histidine kinase activity
A6K25_RS03720	COG3447	MASE1 domain protein
A6K25_RS03720	COG5001	Diguanylate cyclase
A6K25_RS03745	COG0668	transmembrane transport
A6K25_RS03750	COG2081	HI0933 family
A6K25_RS03755	COG3842	ATPase activity
A6K25_RS03760	COG1178	ABC-type Fe3 transport system permease component
A6K25_RS03780	COG0678	peroxiredoxin activity
A6K25_RS03780	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6K25_RS03790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6K25_RS03795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6K25_RS03805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6K25_RS03815	COG0194	GDP metabolic process
A6K25_RS03830	COG0181	hydroxymethylbilane synthase activity
A6K25_RS03840	COG2959	enzyme of heme biosynthesis
A6K25_RS03845	COG3071	HemY protein
A6K25_RS03850	COG2963	transposase activity
A6K25_RS03855	COG2801	Transposase and inactivated derivatives
A6K25_RS03865	COG1953	Uracil, thiamine, allantoin
A6K25_RS03890	COG1309	transcriptional regulator
A6K25_RS03895	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6K25_RS03900	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6K25_RS03905	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6K25_RS03915	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A6K25_RS03915	COG0778	Nitroreductase
A6K25_RS03925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6K25_RS03930	COG4771	TonB-dependent receptor
A6K25_RS03945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6K25_RS03960	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6K25_RS03980	COG3106	COG3106 Predicted ATPase
A6K25_RS03995	COG0583	DNA-binding transcription factor activity
A6K25_RS04000	COG1960	acyl-CoA dehydrogenase activity
A6K25_RS04010	COG0842	Transport permease protein
A6K25_RS04015	COG0842	Transport permease protein
A6K25_RS04015	COG1129	ABC transporter
A6K25_RS04020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6K25_RS04035	COG0583	DNA-binding transcription factor activity
A6K25_RS04040	COG4773	Receptor
A6K25_RS04045	COG4999	Histidine kinase
A6K25_RS04045	COG3437	response regulator, receiver
A6K25_RS04045	COG2205	protein histidine kinase activity
A6K25_RS04045	COG3850	Histidine kinase
A6K25_RS04050	COG0457	Tetratricopeptide repeat
A6K25_RS04055	COG4771	TonB-dependent receptor
A6K25_RS04060	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_RS04070	COG4948	Mandelate Racemase Muconate Lactonizing
A6K25_RS04075	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_RS04090	COG0583	DNA-binding transcription factor activity
A6K25_RS04095	COG1760	l-serine dehydratase
A6K25_RS04140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6K25_RS04155	COG4638	Rieske (2fe-2S)
A6K25_RS04175	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6K25_RS04175	COG1902	pentaerythritol trinitrate reductase activity
A6K25_RS04180	COG2181	nitrate reductase activity
A6K25_RS04180	COG0247	lactate metabolic process
A6K25_RS04195	COG1620	l-lactate permease
A6K25_RS04200	COG0556	nucleotide-excision repair
A6K25_RS04210	COG0326	Molecular chaperone. Has ATPase activity
A6K25_RS04225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6K25_RS04235	COG1757	Na H antiporter
A6K25_RS04255	COG0210	DNA helicase
A6K25_RS04260	COG2960	long-chain fatty acid transporting porin activity
A6K25_RS04265	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6K25_RS04270	COG3161	chorismate lyase activity
A6K25_RS04280	COG0705	Rhomboid family
A6K25_RS04285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6K25_RS04295	COG0156	8-amino-7-oxononanoate synthase activity
A6K25_RS04315	COG0859	PFAM glycosyl transferase family 9
A6K25_RS04320	COG3642	lipopolysaccharide core region biosynthetic process
A6K25_RS04360	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6K25_RS04385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6K25_RS04400	COG2234	aminopeptidase activity
A6K25_RS04420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6K25_RS04505	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6K25_RS04520	COG3047	cAMP biosynthetic process
A6K25_RS04525	COG0408	coproporphyrinogen oxidase activity
A6K25_RS04530	COG0009	L-threonylcarbamoyladenylate synthase
A6K25_RS04545	COG0758	DNA mediated transformation
A6K25_RS04565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6K25_RS04565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6K25_RS04570	COG0569	domain protein
A6K25_RS04580	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A6K25_RS04585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6K25_RS04585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6K25_RS04600	COG3078	GTPase activator activity
A6K25_RS04610	COG2818	Glycosylase
A6K25_RS04635	COG0187	DNA topoisomerase II activity
A6K25_RS04640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6K25_RS04655	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6K25_RS04660	COG0594	ribonuclease P activity
A6K25_RS04665	COG0706	membrane insertase activity
A6K25_RS04675	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6K25_RS04680	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6K25_RS04705	COG1192	Involved in chromosome partitioning
A6K25_RS04710	COG1475	DNA binding
A6K25_RS04730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6K25_RS04735	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6K25_RS04755	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6K25_RS04785	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A6K25_RS04785	COG2199	diguanylate cyclase activity
A6K25_RS04800	COG1609	Transcriptional regulator
A6K25_RS04805	COG2211	Major facilitator Superfamily
A6K25_RS04810	COG2723	6-phospho-beta-galactosidase activity
A6K25_RS04840	COG1561	YicC-like family, N-terminal region
A6K25_RS04855	COG0425	Belongs to the sulfur carrier protein TusA family
A6K25_RS04905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6K25_RS04925	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6K25_RS04935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6K25_RS04960	COG2911	Protein conserved in bacteria
A6K25_RS04965	COG0729	surface antigen
A6K25_RS04975	COG2814	Major facilitator Superfamily
A6K25_RS04990	COG0606	chelatase, subunit chli
A6K25_RS05005	COG0129	dihydroxy-acid dehydratase activity
A6K25_RS05035	COG1565	acr, cog1565
A6K25_RS05035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6K25_RS05040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6K25_RS05045	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A6K25_RS05070	COG1612	heme a metabolic process
A6K25_RS05075	COG0109	protoheme IX farnesyltransferase activity
A6K25_RS05080	COG1999	signal sequence binding
A6K25_RS05095	COG0534	Mate efflux family protein
A6K25_RS05100	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A6K25_RS05115	COG1794	racemase activity, acting on amino acids and derivatives
A6K25_RS05135	COG1040	competence protein
A6K25_RS05140	COG0596	Alpha beta hydrolase
A6K25_RS05155	COG2183	response to ionizing radiation
A6K25_RS05160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6K25_RS05170	COG0545	Peptidyl-prolyl cis-trans isomerase
A6K25_RS05195	COG0488	(ABC) transporter
A6K25_RS05205	COG0429	hydrolase of the alpha beta-hydrolase fold
A6K25_RS05210	COG3089	Belongs to the UPF0270 family
A6K25_RS05220	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A6K25_RS05225	COG2943	transferase activity, transferring hexosyl groups
A6K25_RS05235	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6K25_RS05240	COG0494	nUDIX hydrolase
A6K25_RS05245	COG1011	Hydrolase
A6K25_RS05255	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_RS05260	COG1234	tRNA 3'-trailer cleavage
A6K25_RS05270	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6K25_RS05285	COG4795	General secretion pathway protein
A6K25_RS05290	COG2165	general secretion pathway protein
A6K25_RS05300	COG2165	general secretion pathway protein
A6K25_RS05305	COG1459	type II secretion system
A6K25_RS05320	COG3031	protein transport across the cell outer membrane
A6K25_RS05330	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6K25_RS05335	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6K25_RS05365	COG2233	PERMEase
A6K25_RS05370	COG3954	Phosphoribulokinase
A6K25_RS05380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6K25_RS05390	COG0151	Belongs to the GarS family
A6K25_RS05405	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A6K25_RS05410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6K25_RS05425	COG0154	amidase activity
A6K25_RS05445	COG2176	DNA-directed DNA polymerase activity
A6K25_RS05465	COG0439	Biotin carboxylase
A6K25_RS05470	COG0511	ligase activity, forming carbon-carbon bonds
A6K25_RS05475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6K25_RS05480	COG0739	heme binding
A6K25_RS05485	COG4232	protein-disulfide reductase activity
A6K25_RS05515	COG0523	cobalamin synthesis protein
A6K25_RS05525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6K25_RS05545	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6K25_RS05555	COG1166	arginine decarboxylase activity
A6K25_RS05565	COG4977	sequence-specific DNA binding
A6K25_RS05570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6K25_RS05575	COG0697	spore germination
A6K25_RS05590	COG1349	DNA-binding transcription factor activity
A6K25_RS05595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6K25_RS05625	COG4771	TonB-dependent receptor
A6K25_RS05640	COG0523	cobalamin synthesis protein
A6K25_RS05660	COG4181	ATPase activity
A6K25_RS05670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6K25_RS05690	COG2203	Gaf domain
A6K25_RS05690	COG3706	GGDEF domain
A6K25_RS05690	COG4251	negative regulation of phosphorylation
A6K25_RS05690	COG5001	Diguanylate cyclase
A6K25_RS05695	COG2130	NADP-dependent
A6K25_RS05700	COG2067	long-chain fatty acid transport protein
A6K25_RS05725	COG1252	NADH dehydrogenase
A6K25_RS05730	COG2353	YceI-like domain
A6K25_RS05735	COG3038	cytochrome b561
A6K25_RS05760	COG2267	carboxylic ester hydrolase activity
A6K25_RS05785	COG1404	Belongs to the peptidase S8 family
A6K25_RS05805	COG3237	CsbD-like
A6K25_RS05845	COG4319	ketosteroid isomerase
A6K25_RS05870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6K25_RS05905	COG2204	response regulator
A6K25_RS05920	COG1294	oxidase, subunit
A6K25_RS05930	COG4988	ABC transporter
A6K25_RS05935	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6K25_RS05940	COG4771	TonB-dependent receptor
A6K25_RS05975	COG1230	cation diffusion facilitator family transporter
A6K25_RS05980	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6K25_RS05995	COG2188	Transcriptional regulator
A6K25_RS06000	COG0656	L-ascorbic acid biosynthetic process
A6K25_RS06005	COG2175	clavaminate synthase activity
A6K25_RS06010	COG2855	membrane
A6K25_RS06025	COG1472	Belongs to the glycosyl hydrolase 3 family
A6K25_RS06035	COG4206	TonB-dependent receptor
A6K25_RS06045	COG4558	Periplasmic binding protein
A6K25_RS06050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6K25_RS06055	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6K25_RS06065	COG2723	6-phospho-beta-galactosidase activity
A6K25_RS06070	COG2211	Major facilitator Superfamily
A6K25_RS06075	COG1609	Transcriptional regulator
A6K25_RS06085	COG4191	Histidine kinase
A6K25_RS06085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6K25_RS06090	COG0840	transmembrane signaling receptor activity
A6K25_RS06100	COG5002	protein histidine kinase activity
A6K25_RS06130	COG2258	MOSC domain
A6K25_RS06155	COG0305	Participates in initiation and elongation during chromosome replication
A6K25_RS06175	COG0735	belongs to the Fur family
A6K25_RS06180	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
A6K25_RS06185	COG2816	NAD+ diphosphatase activity
A6K25_RS06200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6K25_RS06205	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6K25_RS06205	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6K25_RS06210	COG0802	atpase or kinase
A6K25_RS06225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6K25_RS06230	COG1923	regulation of RNA biosynthetic process
A6K25_RS06235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6K25_RS06240	COG0330	HflC and HflK could
A6K25_RS06245	COG0330	HflC and HflK could
A6K25_RS06250	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6K25_RS06255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6K25_RS06270	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_RS06280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6K25_RS06285	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A6K25_RS06300	COG0625	glutathione transferase activity
A6K25_RS06315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6K25_RS06325	COG1793	dna ligase
A6K25_RS06335	COG1201	RNA secondary structure unwinding
A6K25_RS06340	COG3306	glycosyltransferase involved in LPS biosynthesis
A6K25_RS06355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6K25_RS06360	COG2957	Belongs to the agmatine deiminase family
A6K25_RS06380	COG0302	gtp cyclohydrolase
A6K25_RS06395	COG0346	lactoylglutathione lyase activity
A6K25_RS06400	COG4989	oxidoreductase activity
A6K25_RS06405	COG3040	lipid binding
A6K25_RS06415	COG0418	dihydroorotase activity
A6K25_RS06420	COG0513	Belongs to the DEAD box helicase family
A6K25_RS06430	COG3590	peptidase
A6K25_RS06435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6K25_RS06440	COG1132	(ABC) transporter
A6K25_RS06450	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6K25_RS06455	COG0250	Participates in transcription elongation, termination and antitermination
A6K25_RS06460	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6K25_RS06465	COG0081	regulation of translation
A6K25_RS06470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6K25_RS06475	COG0222	ribosome binding
A6K25_RS06480	COG0085	RNA polymerase activity
A6K25_RS06485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6K25_RS06490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6K25_RS06495	COG0049	tRNA binding
A6K25_RS06500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6K25_RS06535	COG1252	NADH dehydrogenase
A6K25_RS06545	COG0657	acetylesterase activity
A6K25_RS06560	COG1966	Carbon starvation protein
A6K25_RS06565	COG0701	Predicted permease
A6K25_RS06570	COG1253	flavin adenine dinucleotide binding
A6K25_RS06590	COG4774	siderophore transport
A6K25_RS06595	COG2205	protein histidine kinase activity
A6K25_RS06600	COG0745	RESPONSE REGULATOR receiver
A6K25_RS06605	COG1131	(ABC) transporter
A6K25_RS06610	COG0842	Transport permease protein
A6K25_RS06620	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A6K25_RS06625	COG0076	glutamate decarboxylase activity
A6K25_RS06640	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6K25_RS06650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6K25_RS06655	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6K25_RS06675	COG2095	MarC family integral membrane protein
A6K25_RS06685	COG0742	ribosomal rna small subunit methyltransferase
A6K25_RS06690	COG0552	protein localization to endoplasmic reticulum
A6K25_RS06695	COG2884	Cell division ATP-binding protein ftsE
A6K25_RS06700	COG2177	Part of the ABC transporter FtsEX involved in
A6K25_RS06705	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6K25_RS06710	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6K25_RS06720	COG0456	acetyltransferase
A6K25_RS06750	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6K25_RS06755	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
A6K25_RS06760	COG0281	malic enzyme
A6K25_RS06775	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6K25_RS06780	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6K25_RS06785	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6K25_RS06825	COG4946	Tricorn protease homolog
A6K25_RS06825	COG0793	Belongs to the peptidase S41A family
A6K25_RS06830	COG0243	molybdopterin cofactor binding
A6K25_RS06835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6K25_RS06845	COG4191	Histidine kinase
A6K25_RS06845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6K25_RS06855	COG2201	protein-glutamate methylesterase activity
A6K25_RS06860	COG0339	signal peptide processing
A6K25_RS06880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6K25_RS06885	COG1278	Cold shock
A6K25_RS06900	COG1522	sequence-specific DNA binding
A6K25_RS06905	COG0840	transmembrane signaling receptor activity
A6K25_RS06910	COG1294	oxidase, subunit
A6K25_RS06915	COG1271	oxidase subunit
A6K25_RS06935	COG2234	aminopeptidase activity
A6K25_RS06940	COG0543	2 iron, 2 sulfur cluster binding
A6K25_RS06955	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A6K25_RS06970	COG0557	exoribonuclease II activity
A6K25_RS06975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6K25_RS07025	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6K25_RS07045	COG0201	protein transport
A6K25_RS07065	COG0202	RNA polymerase activity
A6K25_RS07075	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A6K25_RS07075	COG0662	Cupin 2, conserved barrel domain protein
A6K25_RS07095	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6K25_RS07100	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6K25_RS07170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6K25_RS07175	COG1216	Glycosyl transferase, family 2
A6K25_RS07180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6K25_RS07210	COG1216	Glycosyl transferase, family 2
A6K25_RS07210	COG0438	transferase activity, transferring glycosyl groups
A6K25_RS07225	COG0583	DNA-binding transcription factor activity
A6K25_RS07285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6K25_RS07290	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6K25_RS07290	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6K25_RS07295	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A6K25_RS07330	COG0753	catalase activity
A6K25_RS07345	COG0667	Aldo Keto reductase
A6K25_RS07350	COG1283	sodium-dependent phosphate transmembrane transporter activity
A6K25_RS07365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6K25_RS07380	COG0189	ligase activity
A6K25_RS07380	COG4067	protein conserved in archaea
A6K25_RS07390	COG0189	ligase activity
A6K25_RS07410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6K25_RS07415	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6K25_RS07415	COG0517	IMP dehydrogenase activity
A6K25_RS07435	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6K25_RS07440	COG0457	Tetratricopeptide repeat
A6K25_RS07450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6K25_RS07455	COG0572	uridine kinase
A6K25_RS07485	COG1438	arginine binding
A6K25_RS07490	COG0039	L-malate dehydrogenase activity
A6K25_RS07500	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6K25_RS07505	COG0545	Peptidyl-prolyl cis-trans isomerase
A6K25_RS07510	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6K25_RS07515	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6K25_RS07520	COG1805	sodium ion transport
A6K25_RS07525	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6K25_RS07530	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6K25_RS07535	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6K25_RS07540	COG2871	sodium ion transport
A6K25_RS07545	COG1477	protein flavinylation
A6K25_RS07555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6K25_RS07565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6K25_RS07580	COG1522	sequence-specific DNA binding
A6K25_RS07595	COG0121	glutamine amidotransferase
A6K25_RS07600	COG0583	DNA-binding transcription factor activity
A6K25_RS07610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6K25_RS07615	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A6K25_RS07625	COG5002	protein histidine kinase activity
A6K25_RS07625	COG5001	Diguanylate cyclase
A6K25_RS07640	COG0702	epimerase
A6K25_RS07645	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6K25_RS07675	COG0457	Tetratricopeptide repeat
A6K25_RS07685	COG0848	biopolymer transport protein
A6K25_RS07710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6K25_RS07725	COG0733	neurotransmitter:sodium symporter activity
A6K25_RS07730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6K25_RS07745	COG0668	transmembrane transport
A6K25_RS07750	COG0204	Acyl-transferase
A6K25_RS07755	COG0204	Acyl-transferase
A6K25_RS07760	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6K25_RS07785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6K25_RS07795	COG1842	Phage shock protein A
A6K25_RS07820	COG4771	TonB-dependent receptor
A6K25_RS07825	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6K25_RS07845	COG3300	MHYT domain
A6K25_RS07845	COG5001	Diguanylate cyclase
A6K25_RS07850	COG1573	uracil-dna glycosylase
A6K25_RS07860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6K25_RS07875	COG1309	transcriptional regulator
A6K25_RS07925	COG0417	DNA replication proofreading
A6K25_RS07935	COG4191	Histidine kinase
A6K25_RS07950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6K25_RS07955	COG0730	response to heat
A6K25_RS07970	COG3568	Endonuclease Exonuclease Phosphatase
A6K25_RS08005	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6K25_RS08005	COG3264	Mechanosensitive ion channel
A6K25_RS08015	COG2186	Transcriptional regulator
A6K25_RS08020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6K25_RS08025	COG0800	Aldolase
A6K25_RS08030	COG0513	Belongs to the DEAD box helicase family
A6K25_RS08035	COG1131	(ABC) transporter
A6K25_RS08035	COG1716	ATPase activity
A6K25_RS08035	COG0842	Transport permease protein
A6K25_RS08055	COG0515	serine threonine protein kinase
A6K25_RS08055	COG1357	PFAM Pentapeptide repeats (8 copies)
A6K25_RS08090	COG1716	ATPase activity
A6K25_RS08110	COG2271	Major facilitator Superfamily
A6K25_RS08115	COG1917	Cupin 2, conserved barrel domain protein
A6K25_RS08125	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_RS08155	COG1858	cytochrome C peroxidase
A6K25_RS08160	COG4771	TonB-dependent receptor
A6K25_RS08190	COG4585	Histidine kinase
A6K25_RS08195	COG2197	response regulator
A6K25_RS08205	COG3901	Regulator of nitric oxide reductase transcription
A6K25_RS08205	COG0348	domain, Protein
A6K25_RS08215	COG2205	protein histidine kinase activity
A6K25_RS08215	COG0784	Response regulator, receiver
A6K25_RS08245	COG0535	radical SAM domain protein
A6K25_RS08255	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A6K25_RS08260	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6K25_RS08265	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6K25_RS08305	COG3706	GGDEF domain
A6K25_RS08310	COG3706	GGDEF domain
A6K25_RS08330	COG0395	ABC-type sugar transport system, permease component
A6K25_RS08340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6K25_RS08410	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A6K25_RS08490	COG1082	Xylose isomerase domain protein TIM barrel
A6K25_RS08555	COG0795	lipopolysaccharide-transporting ATPase activity
A6K25_RS08560	COG0795	lipopolysaccharide-transporting ATPase activity
A6K25_RS08565	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6K25_RS08570	COG2927	DNA polymerase III (CHI subunit)
A6K25_RS08575	COG0525	valine-tRNA ligase activity
A6K25_RS08610	COG3437	response regulator, receiver
A6K25_RS08620	COG3852	Histidine kinase
A6K25_RS08630	COG0174	glutamine synthetase
A6K25_RS08635	COG1217	gtp-binding protein TYPA
A6K25_RS08645	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6K25_RS08650	COG1914	H( )-stimulated, divalent metal cation uptake system
A6K25_RS08665	COG1981	membrane
A6K25_RS08690	COG0850	regulation of cytokinetic process
A6K25_RS08695	COG2894	cell division
A6K25_RS08715	COG0625	glutathione transferase activity
A6K25_RS08720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6K25_RS08730	COG1902	pentaerythritol trinitrate reductase activity
A6K25_RS08735	COG3659	wide pore channel activity
A6K25_RS08740	COG0738	Major facilitator superfamily
A6K25_RS08760	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A6K25_RS08765	COG0739	heme binding
A6K25_RS08770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6K25_RS08785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6K25_RS08790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6K25_RS08800	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6K25_RS08840	COG1476	TRANSCRIPTIONal
A6K25_RS08850	COG0493	'glutamate synthase
A6K25_RS08855	COG0070	glutamate synthase
A6K25_RS08855	COG0069	glutamate synthase activity
A6K25_RS08855	COG0067	glutamate synthase
A6K25_RS08860	COG5002	protein histidine kinase activity
A6K25_RS08860	COG2198	Histidine kinase
A6K25_RS08860	COG0784	Response regulator, receiver
A6K25_RS08880	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
A6K25_RS08905	COG2203	Gaf domain
A6K25_RS08905	COG2199	diguanylate cyclase activity
A6K25_RS08910	COG2828	Protein conserved in bacteria
A6K25_RS08920	COG0372	Belongs to the citrate synthase family
A6K25_RS08925	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A6K25_RS08935	COG4771	TonB-dependent receptor
A6K25_RS08940	COG2197	response regulator
A6K25_RS08945	COG4585	Histidine kinase
A6K25_RS08990	COG2823	Periplasmic or secreted lipoprotein
A6K25_RS09000	COG0792	nuclease activity
A6K25_RS09005	COG3107	peptidoglycan biosynthetic process
A6K25_RS09010	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6K25_RS09025	COG1748	Saccharopine dehydrogenase
A6K25_RS09050	COG5002	protein histidine kinase activity
A6K25_RS09055	COG0745	RESPONSE REGULATOR receiver
A6K25_RS09060	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A6K25_RS09065	COG2201	protein-glutamate methylesterase activity
A6K25_RS09070	COG0798	PFAM Bile acid sodium symporter
A6K25_RS09075	COG0431	NADPH-dependent FMN reductase
A6K25_RS09085	COG0640	Transcriptional regulator
A6K25_RS09105	COG4585	Histidine kinase
A6K25_RS09110	COG2197	response regulator
A6K25_RS09120	COG0583	DNA-binding transcription factor activity
A6K25_RS09130	COG0083	homoserine kinase activity
A6K25_RS09160	COG0625	glutathione transferase activity
A6K25_RS09165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6K25_RS09180	COG1902	pentaerythritol trinitrate reductase activity
A6K25_RS09180	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6K25_RS09195	COG0762	integral membrane protein
A6K25_RS09200	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6K25_RS09205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6K25_RS09225	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6K25_RS09230	COG1678	Uncharacterized ACR, COG1678
A6K25_RS09235	COG0189	ligase activity
A6K25_RS09240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6K25_RS09245	COG0668	transmembrane transport
A6K25_RS09265	COG2198	Histidine kinase
A6K25_RS09265	COG0784	Response regulator, receiver
A6K25_RS09265	COG5002	protein histidine kinase activity
A6K25_RS09270	COG2204	response regulator
A6K25_RS09285	COG0678	peroxiredoxin activity
A6K25_RS09285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6K25_RS09325	COG2001	Belongs to the MraZ family
A6K25_RS09335	COG3116	cell division
A6K25_RS09340	COG0768	penicillin binding
A6K25_RS09345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6K25_RS09350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6K25_RS09360	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6K25_RS09365	COG0772	Belongs to the SEDS family
A6K25_RS09375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6K25_RS09380	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6K25_RS09385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6K25_RS09390	COG0849	cell division
A6K25_RS09400	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6K25_RS09405	COG0739	heme binding
A6K25_RS09415	COG0494	nUDIX hydrolase
A6K25_RS09420	COG2988	succinylglutamate desuccinylase activity
A6K25_RS09425	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6K25_RS09430	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A6K25_RS09435	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6K25_RS09435	COG0237	dephospho-CoA kinase activity
A6K25_RS09445	COG1459	type II secretion system
A6K25_RS09450	COG4969	Belongs to the N-Me-Phe pilin family
A6K25_RS09480	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6K25_RS09485	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6K25_RS09490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6K25_RS09530	COG3313	Fe-S protein
A6K25_RS09550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6K25_RS09555	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6K25_RS09560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6K25_RS09575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6K25_RS09590	COG0006	proline dipeptidase activity
A6K25_RS09595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6K25_RS09600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6K25_RS09625	COG1629	transport
A6K25_RS09635	COG0477	Major facilitator Superfamily
A6K25_RS09640	COG1621	beta-fructofuranosidase activity
A6K25_RS09660	COG0583	DNA-binding transcription factor activity
A6K25_RS09675	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6K25_RS09675	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6K25_RS09685	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A6K25_RS09700	COG1715	Restriction endonuclease
A6K25_RS09750	COG0656	L-ascorbic acid biosynthetic process
A6K25_RS09760	COG2814	Major facilitator Superfamily
A6K25_RS09810	COG0513	Belongs to the DEAD box helicase family
A6K25_RS09815	COG0697	spore germination
A6K25_RS09825	COG2133	pyrroloquinoline quinone binding
A6K25_RS09845	COG1757	Na H antiporter
A6K25_RS09860	COG0653	protein targeting
A6K25_RS09875	COG1451	nucleotide metabolic process
A6K25_RS09895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6K25_RS09910	COG4249	Peptidase C14 caspase catalytic subunit p20
A6K25_RS09910	COG2319	Wd-40 repeat
A6K25_RS09935	COG3604	Transcriptional regulator
A6K25_RS09950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6K25_RS09950	COG1017	nitric oxide dioxygenase activity
A6K25_RS09955	COG0484	heat shock protein binding
A6K25_RS09965	COG0583	DNA-binding transcription factor activity
A6K25_RS09990	COG0514	ATP-dependent DNA helicase (RecQ)
A6K25_RS10000	COG1295	ribonuclease BN
A6K25_RS10010	COG1846	Transcriptional regulator
A6K25_RS10015	COG1566	PFAM secretion protein HlyD family protein
A6K25_RS10050	COG4771	TonB-dependent receptor
A6K25_RS10070	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
A6K25_RS10075	COG1335	isochorismatase
A6K25_RS10080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6K25_RS10115	COG0789	Transcriptional regulator
A6K25_RS10160	COG2963	transposase activity
A6K25_RS10165	COG2801	Transposase and inactivated derivatives
A6K25_RS10185	COG0693	protein deglycase activity
A6K25_RS10190	COG4221	oxidoreductase activity
A6K25_RS10205	COG0583	DNA-binding transcription factor activity
A6K25_RS10220	COG0109	protoheme IX farnesyltransferase activity
A6K25_RS10235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6K25_RS10240	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6K25_RS10250	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_RS10285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6K25_RS10300	COG1733	regulation of RNA biosynthetic process
A6K25_RS10305	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_RS10320	COG0583	DNA-binding transcription factor activity
A6K25_RS10385	COG0826	peptidase U32
A6K25_RS10390	COG1607	acyl-coa hydrolase
A6K25_RS10440	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6K25_RS10450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6K25_RS10480	COG1960	acyl-CoA dehydrogenase activity
A6K25_RS10535	COG0189	ligase activity
A6K25_RS10550	COG0789	Transcriptional regulator
A6K25_RS10555	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A6K25_RS10585	COG1609	Transcriptional regulator
A6K25_RS10610	COG4682	membrane
A6K25_RS10615	COG4774	siderophore transport
A6K25_RS10615	COG1629	transport
A6K25_RS10630	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_RS10645	COG4774	siderophore transport
A6K25_RS10665	COG1982	Orn Lys Arg decarboxylase major
A6K25_RS10675	COG0515	serine threonine protein kinase
A6K25_RS10700	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A6K25_RS10705	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A6K25_RS10710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6K25_RS10715	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6K25_RS10755	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6K25_RS10760	COG1609	Transcriptional regulator
A6K25_RS10770	COG1435	thymidine kinase activity
A6K25_RS10785	COG1960	acyl-CoA dehydrogenase activity
A6K25_RS10815	COG1560	Kdo2-lipid A biosynthetic process
A6K25_RS10835	COG2827	Endonuclease containing a URI domain
A6K25_RS10840	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6K25_RS10840	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6K25_RS10845	COG3267	Type II secretory pathway component ExeA
A6K25_RS10845	COG3409	Peptidoglycan-binding domain 1 protein
A6K25_RS10855	COG0489	protein tyrosine kinase activity
A6K25_RS10890	COG1216	Glycosyl transferase, family 2
A6K25_RS10890	COG0463	Glycosyl transferase, family 2
A6K25_RS10935	COG0438	transferase activity, transferring glycosyl groups
A6K25_RS10960	COG1045	serine acetyltransferase
A6K25_RS10965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6K25_RS11015	COG0745	RESPONSE REGULATOR receiver
A6K25_RS11020	COG1785	Belongs to the alkaline phosphatase family
A6K25_RS11025	COG2066	Belongs to the glutaminase family
A6K25_RS11040	COG0754	glutathionylspermidine amidase activity
A6K25_RS11065	COG1842	Phage shock protein A
A6K25_RS11070	COG3789	protein conserved in bacteria
A6K25_RS11085	COG0343	queuine tRNA-ribosyltransferase activity
A6K25_RS11090	COG1862	Preprotein translocase
A6K25_RS11095	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6K25_RS11100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6K25_RS11130	COG0483	inositol monophosphate 1-phosphatase activity
A6K25_RS11135	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A6K25_RS11150	COG1104	cysteine desulfurase activity
A6K25_RS11155	COG0719	Fe-S assembly protein
A6K25_RS11160	COG0396	ATPase activity
A6K25_RS11165	COG0719	Fe-S assembly protein
A6K25_RS11170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6K25_RS11185	COG2166	iron-sulfur cluster assembly
A6K25_RS11195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6K25_RS11220	COG2976	Protein conserved in bacteria
A6K25_RS11225	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6K25_RS11240	COG1570	exodeoxyribonuclease VII activity
A6K25_RS11245	COG0517	IMP dehydrogenase activity
A6K25_RS11245	COG0516	GMP reductase activity
A6K25_RS11265	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6K25_RS11285	COG1720	tRNA m6t6A37 methyltransferase activity
A6K25_RS11325	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6K25_RS11330	COG0740	serine-type endopeptidase activity
A6K25_RS11335	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6K25_RS11340	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6K25_RS11345	COG0776	regulation of translation
A6K25_RS11350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6K25_RS11375	COG0385	Bile acid
A6K25_RS11395	COG0268	Binds directly to 16S ribosomal RNA
A6K25_RS11400	COG0728	peptidoglycan biosynthetic process
A6K25_RS11405	COG0196	riboflavin kinase activity
A6K25_RS11410	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6K25_RS11420	COG1047	Peptidyl-prolyl cis-trans
A6K25_RS11425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6K25_RS11485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6K25_RS11505	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A6K25_RS11520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6K25_RS11525	COG1595	DNA-templated transcription, initiation
A6K25_RS11570	COG0084	hydrolase, TatD family'
A6K25_RS11580	COG0560	Phosphoserine phosphatase
A6K25_RS11590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6K25_RS11600	COG0488	(ABC) transporter
A6K25_RS11605	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6K25_RS11620	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6K25_RS11620	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6K25_RS11635	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6K25_RS11645	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6K25_RS11650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6K25_RS11660	COG0142	geranyltranstransferase activity
A6K25_RS11665	COG1722	exodeoxyribonuclease VII activity
A6K25_RS11670	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6K25_RS11680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6K25_RS11690	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A6K25_RS11695	COG4221	oxidoreductase activity
A6K25_RS11710	COG1595	DNA-templated transcription, initiation
A6K25_RS11725	COG0564	pseudouridine synthase activity
A6K25_RS11730	COG1496	oxidoreductase activity
A6K25_RS11735	COG0542	response to heat
A6K25_RS11755	COG1183	phosphatidylcholine synthase activity
A6K25_RS11795	COG4251	negative regulation of phosphorylation
A6K25_RS11795	COG2203	Gaf domain
A6K25_RS11795	COG3706	GGDEF domain
A6K25_RS11795	COG5001	Diguanylate cyclase
A6K25_RS11810	COG4249	Peptidase C14 caspase catalytic subunit p20
A6K25_RS11810	COG2319	Wd-40 repeat
A6K25_RS11820	COG3220	belongs to the UPF0276 family
A6K25_RS11830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6K25_RS11835	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6K25_RS11860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6K25_RS11865	COG0326	Molecular chaperone. Has ATPase activity
A6K25_RS11890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6K25_RS11900	COG0642	Histidine kinase
A6K25_RS11940	COG1022	Amp-dependent synthetase and ligase
A6K25_RS11950	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_RS11960	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6K25_RS11960	COG0140	phosphoribosyl-ATP diphosphatase activity
A6K25_RS11975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6K25_RS11980	COG0131	Imidazoleglycerol-phosphate dehydratase
A6K25_RS11980	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6K25_RS11985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6K25_RS11990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6K25_RS11995	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6K25_RS12055	COG1199	ATP-dependent helicase activity
A6K25_RS12060	COG1214	PFAM Peptidase M22, glycoprotease
A6K25_RS12075	COG2267	carboxylic ester hydrolase activity
A6K25_RS12080	COG0318	PFAM AMP-dependent synthetase and ligase
A6K25_RS12085	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6K25_RS12100	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6K25_RS12105	COG2983	Belongs to the UPF0260 family
A6K25_RS12110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6K25_RS12115	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A6K25_RS12125	COG2186	Transcriptional regulator
A6K25_RS12160	COG4399	Belongs to the UPF0754 family
A6K25_RS12165	COG1309	transcriptional regulator
A6K25_RS12170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6K25_RS12195	COG1902	pentaerythritol trinitrate reductase activity
A6K25_RS12195	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6K25_RS12260	COG3101	peptidyl-lysine hydroxylation
A6K25_RS12290	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6K25_RS12290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6K25_RS12315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6K25_RS12330	COG0101	tRNA pseudouridine synthase activity
A6K25_RS12345	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A6K25_RS12350	COG1286	toxin biosynthetic process
A6K25_RS12355	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6K25_RS12370	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
A6K25_RS12380	COG0604	alcohol dehydrogenase
A6K25_RS12390	COG2080	2 iron, 2 sulfur cluster binding
A6K25_RS12395	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A6K25_RS12400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6K25_RS12405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6K25_RS12425	COG2268	Band 7 protein
A6K25_RS12440	COG1785	Belongs to the alkaline phosphatase family
A6K25_RS12445	COG1785	Belongs to the alkaline phosphatase family
A6K25_RS12455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6K25_RS12475	COG1388	LysM domain
A6K25_RS12475	COG0741	lytic transglycosylase activity
A6K25_RS12480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6K25_RS12485	COG2226	methyltransferase
A6K25_RS12490	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6K25_RS12490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6K25_RS12495	COG0489	protein tyrosine kinase activity
A6K25_RS12505	COG0471	metal ion transport
A6K25_RS12525	COG0778	Nitroreductase
A6K25_RS12545	COG0330	HflC and HflK could
A6K25_RS12555	COG0753	catalase activity
A6K25_RS12565	COG0840	transmembrane signaling receptor activity
A6K25_RS12625	COG5002	protein histidine kinase activity
A6K25_RS12625	COG3850	Histidine kinase
A6K25_RS12630	COG0745	RESPONSE REGULATOR receiver
A6K25_RS12655	COG1764	response to oxidative stress
A6K25_RS12660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6K25_RS12670	COG0746	molybdenum cofactor guanylyltransferase activity
A6K25_RS12700	COG0673	inositol 2-dehydrogenase activity
A6K25_RS12705	COG4948	Mandelate Racemase Muconate Lactonizing
A6K25_RS12710	COG1609	Transcriptional regulator
A6K25_RS12730	COG1024	Enoyl-CoA hydratase
A6K25_RS12740	COG2356	endonuclease I
A6K25_RS12760	COG4677	pectinesterase activity
A6K25_RS12770	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A6K25_RS12780	COG2755	lipolytic protein G-D-S-L family
A6K25_RS12785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6K25_RS12790	COG0246	Mannitol dehydrogenase
A6K25_RS12795	COG1904	glucuronate isomerase
A6K25_RS12800	COG2721	sulfolactate sulfo-lyase activity
A6K25_RS12825	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A6K25_RS12830	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_RS12840	COG3665	Urea carboxylase-associated protein
A6K25_RS12865	COG0745	RESPONSE REGULATOR receiver
A6K25_RS12870	COG2205	protein histidine kinase activity
A6K25_RS12915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6K25_RS12920	COG0469	pyruvate kinase activity
A6K25_RS12925	COG1737	Transcriptional regulator
A6K25_RS12930	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6K25_RS12940	COG0129	dihydroxy-acid dehydratase activity
A6K25_RS12950	COG0800	Aldolase
A6K25_RS12955	COG0676	glucose-6-phosphate 1-epimerase activity
A6K25_RS12965	COG1640	4-alpha-glucanotransferase
A6K25_RS12970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6K25_RS12980	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6K25_RS13000	COG2866	Carboxypeptidase
A6K25_RS13005	COG1115	amino acid carrier protein
A6K25_RS13015	COG3139	Protein of unknown function (DUF1315)
A6K25_RS13040	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6K25_RS13065	COG2205	protein histidine kinase activity
A6K25_RS13065	COG0784	Response regulator, receiver
A6K25_RS13070	COG0784	Response regulator, receiver
A6K25_RS13075	COG4251	negative regulation of phosphorylation
A6K25_RS13085	COG2204	response regulator
A6K25_RS13095	COG0583	DNA-binding transcription factor activity
A6K25_RS13105	COG0640	Transcriptional regulator
A6K25_RS13125	COG0583	DNA-binding transcription factor activity
A6K25_RS13140	COG3132	Protein of unknown function, DUF480
A6K25_RS13150	COG5001	Diguanylate cyclase
A6K25_RS13150	COG3300	MHYT domain
A6K25_RS13155	COG1022	Amp-dependent synthetase and ligase
A6K25_RS13165	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6K25_RS13170	COG1074	ATP-dependent DNA helicase activity
A6K25_RS13175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6K25_RS13190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6K25_RS13205	COG3268	Saccharopine dehydrogenase
A6K25_RS13210	COG0436	Aminotransferase
A6K25_RS13245	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_RS13455	COG3547	Transposase (IS116 IS110 IS902 family)
A6K25_RS13520	COG0666	response to abiotic stimulus
A6K25_RS13565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6K25_RS13570	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6K25_RS13575	COG0315	cyclic pyranopterin monophosphate synthase activity
A6K25_RS13580	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A6K25_RS13585	COG0314	molybdopterin synthase activity
A6K25_RS13605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6K25_RS13625	COG4771	TonB-dependent receptor
A6K25_RS13635	COG1960	acyl-CoA dehydrogenase activity
A6K25_RS13665	COG0596	Alpha beta hydrolase
A6K25_RS13670	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6K25_RS13670	COG1024	Enoyl-CoA hydratase
A6K25_RS13675	COG0183	Belongs to the thiolase family
A6K25_RS13680	COG1960	acyl-CoA dehydrogenase activity
A6K25_RS13685	COG0596	Alpha beta hydrolase
A6K25_RS13700	COG2390	Transcriptional regulator
A6K25_RS13705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6K25_RS13715	COG0246	Mannitol dehydrogenase
A6K25_RS13735	COG0668	transmembrane transport
A6K25_RS13755	COG0668	transmembrane transport
A6K25_RS13760	COG4771	TonB-dependent receptor
A6K25_RS13780	COG0784	Response regulator, receiver
A6K25_RS13780	COG2198	Histidine kinase
A6K25_RS13780	COG2205	protein histidine kinase activity
A6K25_RS13785	COG3437	response regulator, receiver
A6K25_RS13795	COG0195	Participates in both transcription termination and antitermination
A6K25_RS13810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6K25_RS13820	COG4269	membrane
A6K25_RS13830	COG3706	GGDEF domain
A6K25_RS13835	COG0596	Alpha beta hydrolase
A6K25_RS13845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6K25_RS13845	COG3153	acetyltransferase
A6K25_RS13880	COG4774	siderophore transport
A6K25_RS13905	COG1032	radical SAM domain protein
A6K25_RS13920	COG4771	TonB-dependent receptor
A6K25_RS13935	COG4134	Bacterial extracellular solute-binding protein
A6K25_RS13940	COG4135	transport system, permease component
A6K25_RS13945	COG4136	ATPase activity
A6K25_RS13950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6K25_RS13965	COG2203	Gaf domain
A6K25_RS13965	COG5001	Diguanylate cyclase
A6K25_RS13965	COG4251	negative regulation of phosphorylation
A6K25_RS13965	COG3706	GGDEF domain
A6K25_RS13970	COG3321	synthase
A6K25_RS13970	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_RS13970	COG0604	alcohol dehydrogenase
A6K25_RS13990	COG2203	Gaf domain
A6K25_RS13990	COG3706	GGDEF domain
A6K25_RS13990	COG4251	negative regulation of phosphorylation
A6K25_RS13990	COG5001	Diguanylate cyclase
A6K25_RS14045	COG1012	belongs to the aldehyde dehydrogenase family
A6K25_RS14075	COG2814	Major facilitator Superfamily
A6K25_RS14080	COG4771	TonB-dependent receptor
A6K25_RS14095	COG3311	Transcriptional regulator
A6K25_RS14125	COG0582	viral genome integration into host DNA
A6K25_RS14145	COG2867	negative regulation of translational initiation
A6K25_RS14150	COG2914	Belongs to the UPF0125 (RnfH) family
A6K25_RS14160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6K25_RS14170	COG0457	Tetratricopeptide repeat
A6K25_RS14175	COG2318	DinB family
A6K25_RS14180	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6K25_RS14185	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6K25_RS14190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6K25_RS14200	COG0356	it plays a direct role in the translocation of protons across the membrane
A6K25_RS14220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6K25_RS14240	COG0477	Major facilitator Superfamily
A6K25_RS14265	COG0295	cytidine deaminase activity
A6K25_RS14285	COG1196	nuclear chromosome segregation
A6K25_RS14295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6K25_RS14310	COG1132	(ABC) transporter
A6K25_RS14315	COG1663	tetraacyldisaccharide 4'-kinase activity
A6K25_RS14355	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6K25_RS14360	COG0579	oxidoreductase
A6K25_RS14365	COG0435	Glutathione S-transferase
A6K25_RS14390	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A6K25_RS14395	COG1053	succinate dehydrogenase
A6K25_RS14405	COG0567	Dehydrogenase, E1 component
A6K25_RS14410	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6K25_RS14445	COG4667	esterase of the alpha-beta hydrolase superfamily
A6K25_RS14465	COG0366	Alpha amylase catalytic
A6K25_RS14480	COG1609	Transcriptional regulator
A6K25_RS14490	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_RS14495	COG2267	carboxylic ester hydrolase activity
A6K25_RS14505	COG0616	signal peptide processing
A6K25_RS14530	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6K25_RS14535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6K25_RS14540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6K25_RS14545	COG0386	Belongs to the glutathione peroxidase family
A6K25_RS14550	COG2084	Dehydrogenase
A6K25_RS14560	COG1960	acyl-CoA dehydrogenase activity
A6K25_RS14565	COG1024	Enoyl-CoA hydratase
A6K25_RS14570	COG2226	methyltransferase
A6K25_RS14580	COG3083	sulfuric ester hydrolase activity
A6K25_RS14585	COG3082	Protein of unknown function (DUF1414)
A6K25_RS14590	COG3081	Nucleoid-associated protein
A6K25_RS14620	COG3275	phosphorelay sensor kinase activity
A6K25_RS14625	COG3279	Response regulator of the LytR AlgR family
A6K25_RS14630	COG0205	6-phosphofructokinase activity
A6K25_RS14640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6K25_RS14640	COG2205	protein histidine kinase activity
A6K25_RS14735	COG3547	Transposase (IS116 IS110 IS902 family)
A6K25_RS14745	COG0513	Belongs to the DEAD box helicase family
A6K25_RS14750	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A6K25_RS14755	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A6K25_RS14760	COG0583	DNA-binding transcription factor activity
A6K25_RS14780	COG1760	l-serine dehydratase
A6K25_RS14785	COG0494	nUDIX hydrolase
A6K25_RS14790	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6K25_RS14800	COG1322	Protein conserved in bacteria
A6K25_RS14805	COG1404	Belongs to the peptidase S8 family
A6K25_RS14815	COG0022	dehydrogenase e1 component
A6K25_RS14825	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6K25_RS14830	COG0515	serine threonine protein kinase
A6K25_RS14835	COG1946	Acyl-CoA thioesterase
A6K25_RS14845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6K25_RS14855	COG1956	GAF domain-containing protein
A6K25_RS14870	COG0793	Belongs to the peptidase S41A family
A6K25_RS14875	COG0733	neurotransmitter:sodium symporter activity
A6K25_RS14880	COG1757	Na H antiporter
A6K25_RS14885	COG0308	aminopeptidase N
A6K25_RS14915	COG2902	Dehydrogenase
A6K25_RS14920	COG0167	dihydroorotate dehydrogenase activity
A6K25_RS14935	COG0488	(ABC) transporter
A6K25_RS14945	COG3130	regulation of translation
A6K25_RS14950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6K25_RS14960	COG0415	Belongs to the DNA photolyase family
A6K25_RS14965	COG0415	Belongs to the DNA photolyase family
A6K25_RS14970	COG3046	protein related to deoxyribodipyrimidine photolyase
A6K25_RS14995	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6K25_RS15000	COG0589	response to stress
A6K25_RS15010	COG0069	glutamate synthase activity
A6K25_RS15025	COG2193	ferroxidase activity
A6K25_RS15035	COG3278	Belongs to the heme-copper respiratory oxidase family
A6K25_RS15050	COG2010	Cytochrome c
A6K25_RS15075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6K25_RS15085	COG0037	tRNA processing
A6K25_RS15090	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6K25_RS15110	COG1280	lysine exporter protein (LysE YggA)
A6K25_RS15120	COG2897	thiosulfate sulfurtransferase activity
A6K25_RS15125	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A6K25_RS15130	COG3148	PFAM DTW domain containing protein
A6K25_RS15190	COG0582	viral genome integration into host DNA
A6K25_RS15215	COG0322	excinuclease ABC activity
A6K25_RS15220	COG2197	response regulator
A6K25_RS15225	COG1741	Belongs to the pirin family
A6K25_RS15235	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6K25_RS15265	COG0642	Histidine kinase
A6K25_RS15270	COG0745	RESPONSE REGULATOR receiver
A6K25_RS15295	COG0670	Belongs to the BI1 family
A6K25_RS15305	COG2923	Belongs to the DsrF TusC family
A6K25_RS15315	COG2920	part of a sulfur-relay system
A6K25_RS15320	COG0561	phosphatase activity
A6K25_RS15335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6K25_RS15340	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A6K25_RS15345	COG1674	ftsk spoiiie
A6K25_RS15345	COG0531	amino acid
A6K25_RS15355	COG0686	Belongs to the AlaDH PNT family
A6K25_RS15360	COG0284	orotidine-5'-phosphate decarboxylase activity
A6K25_RS15365	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6K25_RS15370	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A6K25_RS15380	COG0776	regulation of translation
A6K25_RS15385	COG0539	negative regulation of cytoplasmic translation
A6K25_RS15390	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6K25_RS15395	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6K25_RS15400	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6K25_RS15415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6K25_RS15420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6K25_RS15425	COG0633	Ferredoxin
A6K25_RS15430	COG5002	protein histidine kinase activity
A6K25_RS15555	COG1131	(ABC) transporter
A6K25_RS15590	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A6K25_RS15595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6K25_RS15605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6K25_RS15615	COG4783	chaperone-mediated protein folding
A6K25_RS15625	COG1393	Belongs to the ArsC family
A6K25_RS15665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6K25_RS15700	COG0572	uridine kinase
A6K25_RS15705	COG3769	mannosylglycerate metabolic process
A6K25_RS15710	COG1215	transferase activity, transferring glycosyl groups
A6K25_RS15720	COG0303	'Molybdopterin
A6K25_RS15725	COG0534	Mate efflux family protein
A6K25_RS15740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6K25_RS15745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6K25_RS15755	COG0405	Gamma-glutamyltransferase
A6K25_RS15760	COG1024	Enoyl-CoA hydratase
A6K25_RS15795	COG1448	Aminotransferase
A6K25_RS15800	COG1671	Belongs to the UPF0178 family
A6K25_RS15805	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_RS15815	COG1960	acyl-CoA dehydrogenase activity
A6K25_RS15820	COG2207	Transcriptional regulator
A6K25_RS15820	COG1917	Cupin 2, conserved barrel domain protein
A6K25_RS15870	COG0596	Alpha beta hydrolase
A6K25_RS15880	COG0716	FMN binding
A6K25_RS15900	COG3265	gluconokinase activity
A6K25_RS15905	COG1609	Transcriptional regulator
A6K25_RS15915	COG1984	allophanate hydrolase subunit 2
A6K25_RS15925	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A6K25_RS15930	COG2996	Protein conserved in bacteria
A6K25_RS15935	COG1765	OsmC-like protein
A6K25_RS15940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6K25_RS15965	COG0436	Aminotransferase
A6K25_RS15970	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6K25_RS15975	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6K25_RS15985	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6K25_RS15995	COG1238	metal cluster binding
A6K25_RS16040	COG4628	conserved protein (DUF2132)
A6K25_RS16050	COG0454	-acetyltransferase
A6K25_RS16055	COG1119	ATPase activity
A6K25_RS16065	COG1185	polyribonucleotide nucleotidyltransferase activity
A6K25_RS16080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6K25_RS16085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6K25_RS16090	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6K25_RS16130	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6K25_RS16135	COG0149	triose-phosphate isomerase activity
A6K25_RS16140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6K25_RS16145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6K25_RS16155	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6K25_RS16160	COG1534	Rna-binding protein
A6K25_RS16170	COG1067	ATP-dependent peptidase activity
A6K25_RS16175	COG0495	leucyl-tRNA aminoacylation
A6K25_RS16185	COG1466	dna polymerase III delta subunit
A6K25_RS16190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6K25_RS16195	COG0799	negative regulation of ribosome biogenesis
A6K25_RS16200	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6K25_RS16205	COG0768	penicillin binding
A6K25_RS16210	COG0772	Belongs to the SEDS family
A6K25_RS16215	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6K25_RS16220	COG1686	Belongs to the peptidase S11 family
A6K25_RS16225	COG2921	Belongs to the UPF0250 family
A6K25_RS16230	COG0321	lipoyl(octanoyl) transferase activity
A6K25_RS16235	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6K25_RS16245	COG0252	asparaginase activity
A6K25_RS16255	COG0778	Nitroreductase
A6K25_RS16270	COG0616	signal peptide processing
A6K25_RS16290	COG0492	ferredoxin-NADP+ reductase activity
A6K25_RS16295	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6K25_RS16300	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A6K25_RS16305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6K25_RS16310	COG0542	response to heat
A6K25_RS16315	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6K25_RS16320	COG1278	Cold shock
A6K25_RS16330	COG1187	pseudouridine synthase activity
A6K25_RS16335	COG0482	sulfurtransferase activity
A6K25_RS16340	COG2915	High frequency lysogenization protein hflD homolog
A6K25_RS16345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6K25_RS16360	COG2850	peptidyl-arginine hydroxylation
A6K25_RS16375	COG0247	lactate metabolic process
A6K25_RS16375	COG0277	FAD linked oxidase domain protein
A6K25_RS16380	COG3123	guanosine phosphorylase activity
A6K25_RS16385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6K25_RS16430	COG1695	Transcriptional regulator
A6K25_RS16445	COG1077	Cell shape determining protein MreB Mrl
A6K25_RS16470	COG3265	gluconokinase activity
A6K25_RS16480	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_RS16495	COG1609	Transcriptional regulator
A6K25_RS16500	COG0679	Auxin Efflux Carrier
A6K25_RS16520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6K25_RS16520	COG0574	Belongs to the PEP-utilizing enzyme family
A6K25_RS16540	COG1942	4-Oxalocrotonate Tautomerase
A6K25_RS16560	COG1714	RDD family
A6K25_RS16585	COG0702	epimerase
A6K25_RS16595	COG0084	hydrolase, TatD family'
A6K25_RS16600	COG0470	DNA polymerase III
A6K25_RS16610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6K25_RS16615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6K25_RS16620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6K25_RS16625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6K25_RS16640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6K25_RS16645	COG0416	fatty acid biosynthetic process
A6K25_RS16655	COG1399	metal-binding, possibly nucleic acid-binding protein
A6K25_RS16660	COG0424	maF-like protein
A6K25_RS16665	COG0546	phosphoglycolate phosphatase activity
A6K25_RS16675	COG1530	ribonuclease E activity
A6K25_RS16695	COG2153	protein acetylation
A6K25_RS16715	COG0625	glutathione transferase activity
A6K25_RS16730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6K25_RS16740	COG0583	DNA-binding transcription factor activity
A6K25_RS16750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6K25_RS16755	COG3724	N-succinylarginine dihydrolase activity
A6K25_RS16765	COG1301	dicarboxylic acid transport
A6K25_RS16770	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6K25_RS16780	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A6K25_RS16815	COG0328	RNA-DNA hybrid ribonuclease activity
A6K25_RS16820	COG0604	alcohol dehydrogenase
A6K25_RS16820	COG3321	synthase
A6K25_RS16840	COG1643	Atp-dependent helicase
A6K25_RS16885	COG3437	response regulator, receiver
A6K25_RS16885	COG4999	Histidine kinase
A6K25_RS16885	COG3850	Histidine kinase
A6K25_RS16885	COG2205	protein histidine kinase activity
A6K25_RS16890	COG2925	Exonuclease
A6K25_RS16905	COG0183	Belongs to the thiolase family
A6K25_RS16910	COG0789	Transcriptional regulator
A6K25_RS16915	COG1960	acyl-CoA dehydrogenase activity
A6K25_RS16920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6K25_RS16925	COG1024	Enoyl-CoA hydratase
A6K25_RS16930	COG4770	biotin carboxylase activity
A6K25_RS16960	COG1957	nucleoside hydrolase
A6K25_RS16975	COG2814	Major facilitator Superfamily
A6K25_RS17010	COG0708	Exodeoxyribonuclease III
A6K25_RS17030	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6K25_RS17040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6K25_RS17050	COG2096	Adenosyltransferase
A6K25_RS17055	COG0471	metal ion transport
A6K25_RS17060	COG1472	Belongs to the glycosyl hydrolase 3 family
A6K25_RS17070	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6K25_RS17085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6K25_RS17085	COG0072	phenylalanine-tRNA ligase activity
A6K25_RS17100	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6K25_RS17100	COG2755	lipolytic protein G-D-S-L family
A6K25_RS17140	COG2327	Polysaccharide pyruvyl transferase
A6K25_RS17160	COG1215	transferase activity, transferring glycosyl groups
A6K25_RS17175	COG0438	transferase activity, transferring glycosyl groups
A6K25_RS17210	COG4464	protein tyrosine phosphatase activity
A6K25_RS17215	COG0489	protein tyrosine kinase activity
A6K25_RS17220	COG1596	polysaccharide export
A6K25_RS17230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6K25_RS17250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6K25_RS17260	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_RS17290	COG0154	amidase activity
A6K25_RS17300	COG0730	response to heat
A6K25_RS17305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6K25_RS17320	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6K25_RS17325	COG2233	PERMEase
A6K25_RS17340	COG0784	Response regulator, receiver
A6K25_RS17340	COG2205	protein histidine kinase activity
A6K25_RS17350	COG3300	MHYT domain
A6K25_RS17350	COG5001	Diguanylate cyclase
A6K25_RS17360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6K25_RS17365	COG2252	PERMEase
A6K25_RS17380	COG1309	transcriptional regulator
A6K25_RS17390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6K25_RS17405	COG2351	hydroxyisourate hydrolase activity
A6K25_RS17410	COG0402	S-adenosylhomocysteine deaminase activity
A6K25_RS17420	COG3447	MASE1 domain protein
A6K25_RS17420	COG5001	Diguanylate cyclase
A6K25_RS17420	COG5002	protein histidine kinase activity
A6K25_RS17440	COG3706	GGDEF domain
A6K25_RS17455	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A6K25_RS17475	COG2190	(PTS) system
A6K25_RS17475	COG2211	Major facilitator Superfamily
A6K25_RS17480	COG1393	Belongs to the ArsC family
A6K25_RS17510	COG2988	succinylglutamate desuccinylase activity
A6K25_RS17520	COG0058	SHG alpha-glucan phosphorylase activity
A6K25_RS17525	COG0033	Phosphoglucomutase
A6K25_RS17530	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A6K25_RS17535	COG0714	Associated with various cellular activities
A6K25_RS17550	COG2116	formate transmembrane transporter activity
A6K25_RS17555	COG0515	serine threonine protein kinase
A6K25_RS17555	COG2815	serine threonine protein kinase
A6K25_RS17560	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
A6K25_RS17565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6K25_RS17585	COG0583	DNA-binding transcription factor activity
A6K25_RS17595	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A6K25_RS17605	COG0784	Response regulator, receiver
A6K25_RS17605	COG3437	response regulator, receiver
A6K25_RS17610	COG2890	protein-(glutamine-N5) methyltransferase activity
A6K25_RS17620	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6K25_RS17625	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A6K25_RS17630	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6K25_RS17640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6K25_RS17645	COG5001	Diguanylate cyclase
A6K25_RS17655	COG1064	alcohol dehydrogenase
A6K25_RS17670	COG0012	GTP binding
A6K25_RS17675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6K25_RS17700	COG1115	amino acid carrier protein
A6K25_RS17705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6K25_RS17720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6K25_RS17730	COG1702	phosphate starvation-inducible protein PhoH
A6K25_RS17740	COG4535	Mg2 and Co2 transporter CorC
A6K25_RS17745	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6K25_RS17750	COG0857	belongs to the CobB CobQ family
A6K25_RS17750	COG0280	phosphate acetyltransferase
A6K25_RS17760	COG0071	Belongs to the small heat shock protein (HSP20) family
A6K25_RS17790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6K25_RS17795	COG0505	Belongs to the CarA family
A6K25_RS17800	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6K25_RS17815	COG5001	Diguanylate cyclase
A6K25_RS17815	COG2203	Gaf domain
A6K25_RS17815	COG3706	GGDEF domain
A6K25_RS17815	COG4251	negative regulation of phosphorylation
A6K25_RS17820	COG3909	cytochrome
A6K25_RS17825	COG0484	heat shock protein binding
A6K25_RS17835	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6K25_RS17840	COG0784	Response regulator, receiver
A6K25_RS17840	COG2205	protein histidine kinase activity
A6K25_RS17850	COG4771	TonB-dependent receptor
A6K25_RS17855	COG2610	gluconate transmembrane transporter activity
A6K25_RS17860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6K25_RS17870	COG1028	Short-chain dehydrogenase reductase Sdr
A6K25_RS17875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6K25_RS17880	COG0497	DNA recombination
A6K25_RS17885	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6K25_RS17890	COG0500	methyltransferase
A6K25_RS17895	COG2733	membrane
A6K25_RS17910	COG0110	maltose O-acetyltransferase activity
A6K25_RS17915	COG0656	L-ascorbic acid biosynthetic process
A6K25_RS17930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6K25_RS17935	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6K25_RS17940	COG0009	L-threonylcarbamoyladenylate synthase
A6K25_RS17945	COG0613	PHP domain protein
A6K25_RS17950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6K25_RS17960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6K25_RS17965	COG0134	indole-3-glycerol-phosphate synthase activity
A6K25_RS17965	COG0135	phosphoribosylanthranilate isomerase activity
A6K25_RS17975	COG0159	tryptophan synthase activity
A6K25_RS17980	COG2350	Protein conserved in bacteria
A6K25_RS18000	COG2205	protein histidine kinase activity
A6K25_RS18005	COG0628	permease
A6K25_RS18010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6K25_RS18015	COG1090	epimerase
A6K25_RS18020	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A6K25_RS18025	COG4181	ATPase activity
A6K25_RS18045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6K25_RS18085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6K25_RS18105	COG0745	RESPONSE REGULATOR receiver
A6K25_RS18115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6K25_RS18120	COG5265	(ABC) transporter
A6K25_RS18135	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A6K25_RS18145	COG4139	cobalamin transport
A6K25_RS18150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6K25_RS18165	COG2226	methyltransferase
A6K25_RS18165	COG1073	alpha beta
A6K25_RS18170	COG0156	8-amino-7-oxononanoate synthase activity
A6K25_RS18195	COG0456	acetyltransferase
A6K25_RS18200	COG0189	ligase activity
A6K25_RS18215	COG0017	Asparaginyl-tRNA synthetase
A6K25_RS18225	COG2995	paraquat-inducible protein a
A6K25_RS18230	COG3008	intermembrane lipid transfer
A6K25_RS18230	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6K25_RS18260	COG0583	DNA-binding transcription factor activity
A6K25_RS18265	COG1309	transcriptional regulator
A6K25_RS18275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6K25_RS18280	COG0517	IMP dehydrogenase activity
A6K25_RS18295	COG0583	DNA-binding transcription factor activity
A6K25_RS18300	COG3038	cytochrome b561
A6K25_RS18310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6K25_RS18340	COG2271	Major facilitator Superfamily
A6K25_RS18345	COG0784	Response regulator, receiver
A6K25_RS18345	COG2205	protein histidine kinase activity
A6K25_RS18420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6K25_RS18440	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A6K25_RS18445	COG2885	chlorophyll binding
A6K25_RS18450	COG0823	Involved in the tonB-independent uptake of proteins
A6K25_RS18465	COG0811	peptide transport
A6K25_RS18470	COG0824	Thioesterase
A6K25_RS18475	COG2255	four-way junction helicase activity
A6K25_RS18480	COG0632	four-way junction helicase activity
A6K25_RS18485	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6K25_RS18490	COG0494	nUDIX hydrolase
A6K25_RS18495	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6K25_RS18510	COG2204	response regulator
A6K25_RS18520	COG2205	protein histidine kinase activity
A6K25_RS18550	COG0023	Translation Initiation Factor
A6K25_RS18555	COG0745	RESPONSE REGULATOR receiver
A6K25_RS18560	COG0077	Prephenate dehydratase
A6K25_RS18560	COG1605	Chorismate mutase
A6K25_RS18565	COG0840	transmembrane signaling receptor activity
A6K25_RS18570	COG1605	Chorismate mutase
A6K25_RS18570	COG0287	Prephenate dehydrogenase
A6K25_RS18575	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6K25_RS18580	COG2860	membrane
A6K25_RS18595	COG0335	large ribosomal subunit rRNA binding
A6K25_RS18600	COG0336	Belongs to the RNA methyltransferase TrmD family
A6K25_RS18605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6K25_RS18610	COG0228	four-way junction DNA binding
A6K25_RS18625	COG2873	o-acetylhomoserine
A6K25_RS18630	COG1132	(ABC) transporter
A6K25_RS18635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6K25_RS18645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6K25_RS18675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6K25_RS18680	COG4137	Cytochrome C assembly protein
A6K25_RS18685	COG4536	flavin adenine dinucleotide binding
A6K25_RS18695	COG2062	phosphohistidine phosphatase, SixA
A6K25_RS18700	COG1025	Belongs to the peptidase M16 family
A6K25_RS18715	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6K25_RS18715	COG1024	Enoyl-CoA hydratase
A6K25_RS18725	COG0714	Associated with various cellular activities
A6K25_RS18745	COG2304	oxidoreductase activity
A6K25_RS18770	COG3706	GGDEF domain
A6K25_RS18775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6K25_RS18780	COG0175	sulfate reduction
A6K25_RS18785	COG0529	Catalyzes the synthesis of activated sulfate
A6K25_RS18800	COG0471	metal ion transport
A6K25_RS18800	COG3273	potassium ion transport
A6K25_RS18825	COG0367	asparagine synthase
A6K25_RS18835	COG0602	queuosine metabolic process
A6K25_RS18860	COG0556	nucleotide-excision repair
A6K25_RS18865	COG0534	Mate efflux family protein
A6K25_RS18880	COG4657	Part of a membrane complex involved in electron transport
A6K25_RS18885	COG2878	Part of a membrane complex involved in electron transport
A6K25_RS18890	COG4656	Part of a membrane complex involved in electron transport
A6K25_RS18895	COG4658	electron transport chain
A6K25_RS18900	COG4659	FMN binding
A6K25_RS18905	COG4660	Part of a membrane complex involved in electron transport
A6K25_RS18910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6K25_RS18930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6K25_RS18935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6K25_RS18940	COG4946	Tricorn protease homolog
A6K25_RS18940	COG1506	peptidase
A6K25_RS18940	COG0823	Involved in the tonB-independent uptake of proteins
A6K25_RS18965	COG1278	Cold shock
A6K25_RS18970	COG0346	lactoylglutathione lyase activity
A6K25_RS18975	COG0584	glycerophosphoryl diester phosphodiesterase
A6K25_RS18980	COG2885	chlorophyll binding
A6K25_RS18985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6K25_RS18990	COG0450	alkyl hydroperoxide reductase
A6K25_RS19015	COG4771	TonB-dependent receptor
A6K25_RS19020	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6K25_RS19025	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6K25_RS19030	COG2766	serine protein kinase
A6K25_RS19040	COG2719	SpoVR family
A6K25_RS19060	COG2890	protein-(glutamine-N5) methyltransferase activity
A6K25_RS19065	COG2840	Smr protein MutS2
A6K25_RS19090	COG1136	(ABC) transporter
A6K25_RS19110	COG2918	glutathione biosynthetic process
A6K25_RS19115	COG0612	Peptidase, M16
A6K25_RS19125	COG0564	pseudouridine synthase activity
A6K25_RS19130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6K25_RS19135	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6K25_RS19160	COG2175	clavaminate synthase activity
A6K25_RS19190	COG0583	DNA-binding transcription factor activity
A6K25_RS19205	COG0456	acetyltransferase
A6K25_RS19260	COG0848	biopolymer transport protein
A6K25_RS19265	COG0811	peptide transport
A6K25_RS19270	COG0811	peptide transport
A6K25_RS19310	COG0457	Tetratricopeptide repeat
A6K25_RS19340	COG1522	sequence-specific DNA binding
A6K25_RS19345	COG0625	glutathione transferase activity
A6K25_RS19375	COG1842	Phage shock protein A
A6K25_RS19380	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6K25_RS19385	COG0747	negative chemotaxis
A6K25_RS19390	COG4168	peptide transport system, permease
A6K25_RS19395	COG4171	peptide transport system, permease
A6K25_RS19400	COG4172	Belongs to the ABC transporter superfamily
A6K25_RS19405	COG4172	Belongs to the ABC transporter superfamily
A6K25_RS19410	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A6K25_RS19425	COG1607	acyl-coa hydrolase
A6K25_RS19450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6K25_RS19465	COG3590	peptidase
A6K25_RS19470	COG1309	transcriptional regulator
A6K25_RS19480	COG0659	secondary active sulfate transmembrane transporter activity
A6K25_RS19485	COG0288	reversible hydration of carbon dioxide
A6K25_RS19490	COG0583	DNA-binding transcription factor activity
A6K25_RS19495	COG0583	DNA-binding transcription factor activity
A6K25_RS19505	COG0646	methionine synthase
A6K25_RS19505	COG1410	methionine synthase
A6K25_RS19510	COG0646	methionine synthase
A6K25_RS19510	COG1410	methionine synthase
A6K25_RS19525	COG0835	chemotaxis
A6K25_RS19535	COG1192	Involved in chromosome partitioning
A6K25_RS19545	COG0643	Histidine kinase
A6K25_RS19545	COG2198	Histidine kinase
A6K25_RS19545	COG0784	Response regulator, receiver
A6K25_RS19550	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A6K25_RS19575	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6K25_RS19590	COG1987	bacterial-type flagellum assembly
A6K25_RS19640	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6K25_RS19645	COG1766	The M ring may be actively involved in energy transduction
A6K25_RS19675	COG1086	Polysaccharide biosynthesis protein
A6K25_RS19680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6K25_RS19685	COG1083	cytidylyl-transferase
A6K25_RS19695	COG2089	acid synthase
A6K25_RS19710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6K25_RS19750	COG2089	acid synthase
A6K25_RS19755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6K25_RS19760	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A6K25_RS19800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6K25_RS19805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6K25_RS19825	COG1256	bacterial-type flagellum assembly
A6K25_RS19830	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6K25_RS19830	COG3951	Flagellar rod assembly protein muramidase FlgJ
A6K25_RS19850	COG4787	bacterial-type flagellum-dependent cell motility
A6K25_RS19855	COG1749	Flagellar hook protein flgE
A6K25_RS19870	COG1815	bacterial-type flagellum-dependent cell motility
A6K25_RS19875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6K25_RS19880	COG0784	Response regulator, receiver
A6K25_RS19880	COG0835	chemotaxis
A6K25_RS19920	COG2197	response regulator
A6K25_RS19925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6K25_RS19935	COG2885	chlorophyll binding
A6K25_RS19945	COG2963	transposase activity
A6K25_RS19950	COG2801	Transposase and inactivated derivatives
A6K25_RS19965	COG2840	Smr protein MutS2
A6K25_RS19970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6K25_RS19970	COG0047	phosphoribosylformylglycinamidine synthase activity
A6K25_RS20000	COG0037	tRNA processing
A6K25_RS20005	COG0825	malonyl-CoA metabolic process
A6K25_RS20010	COG0587	DNA-directed DNA polymerase activity
A6K25_RS20025	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6K25_RS20030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6K25_RS20045	COG0750	zinc metalloprotease
A6K25_RS20050	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6K25_RS20055	COG0575	Belongs to the CDS family
A6K25_RS20060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6K25_RS20070	COG0528	UMP kinase activity
A6K25_RS20080	COG0052	Belongs to the universal ribosomal protein uS2 family
A6K25_RS20085	COG0024	Methionine aminopeptidase
A6K25_RS20090	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A6K25_RS20105	COG0564	pseudouridine synthase activity
A6K25_RS20175	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6K25_RS20175	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6K25_RS20185	COG1611	Belongs to the LOG family
A6K25_RS20200	COG0473	3-isopropylmalate dehydrogenase activity
A6K25_RS20205	COG1596	polysaccharide export
A6K25_RS20205	COG1555	photosystem II stabilization
A6K25_RS20210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6K25_RS20240	COG1682	transport, permease protein
A6K25_RS20265	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6K25_RS20270	COG2853	Lipoprotein