locus-tag	class	description
A6F57_RS00005	COG0513	Belongs to the DEAD box helicase family
A6F57_RS00015	COG3547	Transposase (IS116 IS110 IS902 family)
A6F57_RS00115	COG2205	protein histidine kinase activity
A6F57_RS00115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6F57_RS00125	COG0205	6-phosphofructokinase activity
A6F57_RS00130	COG3279	Response regulator of the LytR AlgR family
A6F57_RS00135	COG3275	phosphorelay sensor kinase activity
A6F57_RS00165	COG3081	Nucleoid-associated protein
A6F57_RS00170	COG3082	Protein of unknown function (DUF1414)
A6F57_RS00175	COG3083	sulfuric ester hydrolase activity
A6F57_RS00185	COG2226	methyltransferase
A6F57_RS00190	COG1024	Enoyl-CoA hydratase
A6F57_RS00195	COG1960	acyl-CoA dehydrogenase activity
A6F57_RS00205	COG2084	Dehydrogenase
A6F57_RS00210	COG0386	Belongs to the glutathione peroxidase family
A6F57_RS00215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6F57_RS00220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6F57_RS00225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6F57_RS00250	COG0616	signal peptide processing
A6F57_RS00260	COG2267	carboxylic ester hydrolase activity
A6F57_RS00265	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_RS00275	COG1609	Transcriptional regulator
A6F57_RS00290	COG0366	Alpha amylase catalytic
A6F57_RS00310	COG4667	esterase of the alpha-beta hydrolase superfamily
A6F57_RS00345	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F57_RS00350	COG0567	Dehydrogenase, E1 component
A6F57_RS00360	COG1053	succinate dehydrogenase
A6F57_RS00365	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A6F57_RS00390	COG0435	Glutathione S-transferase
A6F57_RS00395	COG0579	oxidoreductase
A6F57_RS00400	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6F57_RS00440	COG1663	tetraacyldisaccharide 4'-kinase activity
A6F57_RS00445	COG1132	(ABC) transporter
A6F57_RS00460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6F57_RS00470	COG1196	nuclear chromosome segregation
A6F57_RS00490	COG0295	cytidine deaminase activity
A6F57_RS00515	COG0477	Major facilitator Superfamily
A6F57_RS00535	COG2318	DinB family
A6F57_RS00540	COG0457	Tetratricopeptide repeat
A6F57_RS00550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6F57_RS00560	COG2914	Belongs to the UPF0125 (RnfH) family
A6F57_RS00565	COG2867	negative regulation of translational initiation
A6F57_RS00585	COG0582	viral genome integration into host DNA
A6F57_RS00620	COG3311	Transcriptional regulator
A6F57_RS00640	COG4771	TonB-dependent receptor
A6F57_RS00645	COG2814	Major facilitator Superfamily
A6F57_RS00675	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_RS00685	COG1595	DNA-templated transcription, initiation
A6F57_RS00690	COG2226	methyltransferase
A6F57_RS00690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F57_RS00690	COG0596	Alpha beta hydrolase
A6F57_RS00715	COG0583	DNA-binding transcription factor activity
A6F57_RS00735	COG3300	MHYT domain
A6F57_RS00735	COG5001	Diguanylate cyclase
A6F57_RS00750	COG3706	GGDEF domain
A6F57_RS00750	COG5001	Diguanylate cyclase
A6F57_RS00750	COG2203	Gaf domain
A6F57_RS00750	COG4251	negative regulation of phosphorylation
A6F57_RS00765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6F57_RS00770	COG4136	ATPase activity
A6F57_RS00780	COG4135	transport system, permease component
A6F57_RS00785	COG4134	Bacterial extracellular solute-binding protein
A6F57_RS00800	COG4771	TonB-dependent receptor
A6F57_RS00815	COG1032	radical SAM domain protein
A6F57_RS00840	COG4774	siderophore transport
A6F57_RS00875	COG3153	acetyltransferase
A6F57_RS00875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F57_RS00885	COG0596	Alpha beta hydrolase
A6F57_RS00890	COG3706	GGDEF domain
A6F57_RS00900	COG4269	membrane
A6F57_RS00910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6F57_RS00925	COG0195	Participates in both transcription termination and antitermination
A6F57_RS00935	COG3437	response regulator, receiver
A6F57_RS00940	COG0784	Response regulator, receiver
A6F57_RS00940	COG2198	Histidine kinase
A6F57_RS00940	COG2205	protein histidine kinase activity
A6F57_RS00960	COG4771	TonB-dependent receptor
A6F57_RS00965	COG0668	transmembrane transport
A6F57_RS00985	COG0668	transmembrane transport
A6F57_RS01005	COG0246	Mannitol dehydrogenase
A6F57_RS01015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6F57_RS01020	COG2390	Transcriptional regulator
A6F57_RS01035	COG0596	Alpha beta hydrolase
A6F57_RS01040	COG1960	acyl-CoA dehydrogenase activity
A6F57_RS01045	COG0183	Belongs to the thiolase family
A6F57_RS01050	COG1024	Enoyl-CoA hydratase
A6F57_RS01050	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6F57_RS01055	COG0596	Alpha beta hydrolase
A6F57_RS01085	COG1960	acyl-CoA dehydrogenase activity
A6F57_RS01095	COG4771	TonB-dependent receptor
A6F57_RS01115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6F57_RS01135	COG0314	molybdopterin synthase activity
A6F57_RS01140	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A6F57_RS01145	COG0315	cyclic pyranopterin monophosphate synthase activity
A6F57_RS01150	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6F57_RS01155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6F57_RS01215	COG2801	Transposase and inactivated derivatives
A6F57_RS01265	COG3547	Transposase (IS116 IS110 IS902 family)
A6F57_RS01330	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_RS01365	COG0436	Aminotransferase
A6F57_RS01370	COG3268	Saccharopine dehydrogenase
A6F57_RS01385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6F57_RS01400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6F57_RS01405	COG1074	ATP-dependent DNA helicase activity
A6F57_RS01410	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6F57_RS01420	COG1022	Amp-dependent synthetase and ligase
A6F57_RS01425	COG5001	Diguanylate cyclase
A6F57_RS01425	COG3300	MHYT domain
A6F57_RS01435	COG3132	Protein of unknown function, DUF480
A6F57_RS01450	COG0583	DNA-binding transcription factor activity
A6F57_RS01470	COG0640	Transcriptional regulator
A6F57_RS01480	COG0583	DNA-binding transcription factor activity
A6F57_RS01490	COG2204	response regulator
A6F57_RS01505	COG0784	Response regulator, receiver
A6F57_RS01510	COG2205	protein histidine kinase activity
A6F57_RS01510	COG0784	Response regulator, receiver
A6F57_RS01535	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6F57_RS01560	COG3139	Protein of unknown function (DUF1315)
A6F57_RS01570	COG1115	amino acid carrier protein
A6F57_RS01575	COG2866	Carboxypeptidase
A6F57_RS01595	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6F57_RS01605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6F57_RS01610	COG1640	4-alpha-glucanotransferase
A6F57_RS01620	COG0676	glucose-6-phosphate 1-epimerase activity
A6F57_RS01625	COG0800	Aldolase
A6F57_RS01635	COG0129	dihydroxy-acid dehydratase activity
A6F57_RS01645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6F57_RS01650	COG1737	Transcriptional regulator
A6F57_RS01655	COG0469	pyruvate kinase activity
A6F57_RS01660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6F57_RS01705	COG2205	protein histidine kinase activity
A6F57_RS01710	COG0745	RESPONSE REGULATOR receiver
A6F57_RS01735	COG3665	Urea carboxylase-associated protein
A6F57_RS01745	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_RS01750	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A6F57_RS01775	COG2721	sulfolactate sulfo-lyase activity
A6F57_RS01780	COG1904	glucuronate isomerase
A6F57_RS01785	COG0246	Mannitol dehydrogenase
A6F57_RS01790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F57_RS01795	COG2755	lipolytic protein G-D-S-L family
A6F57_RS01805	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A6F57_RS01815	COG4677	pectinesterase activity
A6F57_RS01820	COG3437	response regulator, receiver
A6F57_RS01820	COG2205	protein histidine kinase activity
A6F57_RS01820	COG3850	Histidine kinase
A6F57_RS01820	COG4999	Histidine kinase
A6F57_RS01835	COG2356	endonuclease I
A6F57_RS01845	COG1024	Enoyl-CoA hydratase
A6F57_RS01855	COG2801	Transposase and inactivated derivatives
A6F57_RS01870	COG1609	Transcriptional regulator
A6F57_RS01880	COG0673	inositol 2-dehydrogenase activity
A6F57_RS01895	COG5001	Diguanylate cyclase
A6F57_RS01895	COG3300	MHYT domain
A6F57_RS01910	COG0746	molybdenum cofactor guanylyltransferase activity
A6F57_RS01920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F57_RS01925	COG1764	response to oxidative stress
A6F57_RS01950	COG0745	RESPONSE REGULATOR receiver
A6F57_RS01955	COG3850	Histidine kinase
A6F57_RS01955	COG5002	protein histidine kinase activity
A6F57_RS01990	COG0738	Major facilitator superfamily
A6F57_RS02015	COG0840	transmembrane signaling receptor activity
A6F57_RS02025	COG0753	catalase activity
A6F57_RS02035	COG0330	HflC and HflK could
A6F57_RS02055	COG0778	Nitroreductase
A6F57_RS02075	COG0471	metal ion transport
A6F57_RS02085	COG0489	protein tyrosine kinase activity
A6F57_RS02090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F57_RS02090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F57_RS02095	COG2226	methyltransferase
A6F57_RS02100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F57_RS02105	COG1388	LysM domain
A6F57_RS02105	COG0741	lytic transglycosylase activity
A6F57_RS02125	COG2942	2-epimerase
A6F57_RS02130	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A6F57_RS02140	COG1609	Transcriptional regulator
A6F57_RS02145	COG2942	2-epimerase
A6F57_RS02150	COG3119	arylsulfatase activity
A6F57_RS02165	COG4124	Belongs to the glycosyl hydrolase 26 family
A6F57_RS02195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6F57_RS02205	COG1785	Belongs to the alkaline phosphatase family
A6F57_RS02210	COG1785	Belongs to the alkaline phosphatase family
A6F57_RS02225	COG2268	Band 7 protein
A6F57_RS02245	COG0542	response to heat
A6F57_RS02250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6F57_RS02255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6F57_RS02260	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A6F57_RS02265	COG2080	2 iron, 2 sulfur cluster binding
A6F57_RS02275	COG0604	alcohol dehydrogenase
A6F57_RS02285	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
A6F57_RS02300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6F57_RS02305	COG1286	toxin biosynthetic process
A6F57_RS02310	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A6F57_RS02315	COG0285	dihydrofolate synthase activity
A6F57_RS02325	COG0101	tRNA pseudouridine synthase activity
A6F57_RS02340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6F57_RS02365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6F57_RS02365	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6F57_RS02395	COG3101	peptidyl-lysine hydroxylation
A6F57_RS02440	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6F57_RS02440	COG1902	pentaerythritol trinitrate reductase activity
A6F57_RS02465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6F57_RS02470	COG1309	transcriptional regulator
A6F57_RS02475	COG4399	Belongs to the UPF0754 family
A6F57_RS02510	COG2186	Transcriptional regulator
A6F57_RS02520	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A6F57_RS02525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6F57_RS02530	COG2983	Belongs to the UPF0260 family
A6F57_RS02535	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6F57_RS02550	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6F57_RS02555	COG0318	PFAM AMP-dependent synthetase and ligase
A6F57_RS02560	COG2267	carboxylic ester hydrolase activity
A6F57_RS02575	COG1214	PFAM Peptidase M22, glycoprotease
A6F57_RS02580	COG1199	ATP-dependent helicase activity
A6F57_RS02635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6F57_RS02640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6F57_RS02645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6F57_RS02650	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6F57_RS02650	COG0131	Imidazoleglycerol-phosphate dehydratase
A6F57_RS02655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6F57_RS02670	COG0140	phosphoribosyl-ATP diphosphatase activity
A6F57_RS02670	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6F57_RS02690	COG0300	oxidoreductase activity
A6F57_RS02710	COG0583	DNA-binding transcription factor activity
A6F57_RS02725	COG0681	Belongs to the peptidase S26 family
A6F57_RS02745	COG0326	Molecular chaperone. Has ATPase activity
A6F57_RS02750	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6F57_RS02775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6F57_RS02780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6F57_RS02790	COG3220	belongs to the UPF0276 family
A6F57_RS02800	COG2319	Wd-40 repeat
A6F57_RS02800	COG4249	Peptidase C14 caspase catalytic subunit p20
A6F57_RS02855	COG1183	phosphatidylcholine synthase activity
A6F57_RS02875	COG0542	response to heat
A6F57_RS02880	COG1496	oxidoreductase activity
A6F57_RS02885	COG0564	pseudouridine synthase activity
A6F57_RS02900	COG1595	DNA-templated transcription, initiation
A6F57_RS02915	COG4221	oxidoreductase activity
A6F57_RS02920	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A6F57_RS02930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6F57_RS02940	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6F57_RS02945	COG1722	exodeoxyribonuclease VII activity
A6F57_RS02950	COG0142	geranyltranstransferase activity
A6F57_RS02960	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6F57_RS02965	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6F57_RS02975	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6F57_RS02990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6F57_RS02990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6F57_RS03005	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6F57_RS03010	COG0488	(ABC) transporter
A6F57_RS03020	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6F57_RS03030	COG0560	Phosphoserine phosphatase
A6F57_RS03040	COG0084	hydrolase, TatD family'
A6F57_RS03085	COG1595	DNA-templated transcription, initiation
A6F57_RS03090	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6F57_RS03105	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A6F57_RS03125	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6F57_RS03185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6F57_RS03190	COG1047	Peptidyl-prolyl cis-trans
A6F57_RS03200	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6F57_RS03205	COG0196	riboflavin kinase activity
A6F57_RS03210	COG0728	peptidoglycan biosynthetic process
A6F57_RS03215	COG0268	Binds directly to 16S ribosomal RNA
A6F57_RS03230	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_RS03235	COG0385	Bile acid
A6F57_RS03260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6F57_RS03265	COG0776	regulation of translation
A6F57_RS03270	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6F57_RS03275	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6F57_RS03280	COG0740	serine-type endopeptidase activity
A6F57_RS03285	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6F57_RS03325	COG1720	tRNA m6t6A37 methyltransferase activity
A6F57_RS03345	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6F57_RS03365	COG0517	IMP dehydrogenase activity
A6F57_RS03365	COG0516	GMP reductase activity
A6F57_RS03370	COG1570	exodeoxyribonuclease VII activity
A6F57_RS03385	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6F57_RS03390	COG2976	Protein conserved in bacteria
A6F57_RS03415	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6F57_RS03425	COG2166	iron-sulfur cluster assembly
A6F57_RS03440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6F57_RS03445	COG0719	Fe-S assembly protein
A6F57_RS03450	COG0396	ATPase activity
A6F57_RS03455	COG0719	Fe-S assembly protein
A6F57_RS03460	COG1104	cysteine desulfurase activity
A6F57_RS03475	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A6F57_RS03480	COG0483	inositol monophosphate 1-phosphatase activity
A6F57_RS03510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6F57_RS03515	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6F57_RS03520	COG1862	Preprotein translocase
A6F57_RS03525	COG0343	queuine tRNA-ribosyltransferase activity
A6F57_RS03540	COG3789	protein conserved in bacteria
A6F57_RS03545	COG1842	Phage shock protein A
A6F57_RS03570	COG0754	glutathionylspermidine amidase activity
A6F57_RS03585	COG2066	Belongs to the glutaminase family
A6F57_RS03590	COG1785	Belongs to the alkaline phosphatase family
A6F57_RS03595	COG0745	RESPONSE REGULATOR receiver
A6F57_RS03645	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6F57_RS03650	COG1045	serine acetyltransferase
A6F57_RS03675	COG0438	transferase activity, transferring glycosyl groups
A6F57_RS03720	COG0463	Glycosyl transferase, family 2
A6F57_RS03720	COG1216	Glycosyl transferase, family 2
A6F57_RS03755	COG0489	protein tyrosine kinase activity
A6F57_RS03770	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6F57_RS03770	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6F57_RS03775	COG2827	Endonuclease containing a URI domain
A6F57_RS03795	COG1560	Kdo2-lipid A biosynthetic process
A6F57_RS03840	COG1435	thymidine kinase activity
A6F57_RS03850	COG1609	Transcriptional regulator
A6F57_RS03855	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6F57_RS03895	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6F57_RS03900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6F57_RS03905	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A6F57_RS03910	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A6F57_RS03935	COG0515	serine threonine protein kinase
A6F57_RS03945	COG1982	Orn Lys Arg decarboxylase major
A6F57_RS03965	COG4774	siderophore transport
A6F57_RS03980	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_RS03995	COG1629	transport
A6F57_RS03995	COG4774	siderophore transport
A6F57_RS04000	COG4682	membrane
A6F57_RS04015	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A6F57_RS04020	COG0789	Transcriptional regulator
A6F57_RS04035	COG0189	ligase activity
A6F57_RS04090	COG1960	acyl-CoA dehydrogenase activity
A6F57_RS04120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6F57_RS04130	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6F57_RS04180	COG1607	acyl-coa hydrolase
A6F57_RS04185	COG0826	peptidase U32
A6F57_RS04250	COG0583	DNA-binding transcription factor activity
A6F57_RS04265	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_RS04270	COG1733	regulation of RNA biosynthetic process
A6F57_RS04285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6F57_RS04325	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_RS04335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6F57_RS04340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6F57_RS04345	COG1845	cytochrome c oxidase, subunit III
A6F57_RS04355	COG0109	protoheme IX farnesyltransferase activity
A6F57_RS04370	COG0583	DNA-binding transcription factor activity
A6F57_RS04385	COG4221	oxidoreductase activity
A6F57_RS04390	COG0693	protein deglycase activity
A6F57_RS04450	COG0789	Transcriptional regulator
A6F57_RS04480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6F57_RS04485	COG1335	isochorismatase
A6F57_RS04490	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
A6F57_RS04510	COG4771	TonB-dependent receptor
A6F57_RS04545	COG1566	PFAM secretion protein HlyD family protein
A6F57_RS04550	COG1846	Transcriptional regulator
A6F57_RS04560	COG1295	ribonuclease BN
A6F57_RS04575	COG1846	Transcriptional regulator
A6F57_RS04590	COG0583	DNA-binding transcription factor activity
A6F57_RS04600	COG0484	heat shock protein binding
A6F57_RS04625	COG4249	Peptidase C14 caspase catalytic subunit p20
A6F57_RS04625	COG2319	Wd-40 repeat
A6F57_RS04640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6F57_RS04660	COG1451	nucleotide metabolic process
A6F57_RS04675	COG0653	protein targeting
A6F57_RS04690	COG1757	Na H antiporter
A6F57_RS04710	COG2133	pyrroloquinoline quinone binding
A6F57_RS04720	COG0697	spore germination
A6F57_RS04725	COG3813	Protein conserved in bacteria
A6F57_RS04730	COG0513	Belongs to the DEAD box helicase family
A6F57_RS04780	COG2814	Major facilitator Superfamily
A6F57_RS04790	COG0656	L-ascorbic acid biosynthetic process
A6F57_RS04815	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6F57_RS04870	COG1484	DNA-dependent DNA replication
A6F57_RS04900	COG3209	COG3209 Rhs family protein
A6F57_RS04925	COG4974	Belongs to the 'phage' integrase family
A6F57_RS04930	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6F57_RS04930	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6F57_RS04945	COG0583	DNA-binding transcription factor activity
A6F57_RS04960	COG1621	beta-fructofuranosidase activity
A6F57_RS04965	COG0477	Major facilitator Superfamily
A6F57_RS04975	COG1629	transport
A6F57_RS05000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6F57_RS05005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6F57_RS05010	COG0006	proline dipeptidase activity
A6F57_RS05025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F57_RS05040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6F57_RS05045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6F57_RS05050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6F57_RS05070	COG3313	Fe-S protein
A6F57_RS05110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6F57_RS05115	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F57_RS05120	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6F57_RS05150	COG4969	Belongs to the N-Me-Phe pilin family
A6F57_RS05155	COG1459	type II secretion system
A6F57_RS05165	COG0237	dephospho-CoA kinase activity
A6F57_RS05165	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6F57_RS05170	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A6F57_RS05175	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6F57_RS05180	COG2988	succinylglutamate desuccinylase activity
A6F57_RS05185	COG0494	nUDIX hydrolase
A6F57_RS05195	COG0739	heme binding
A6F57_RS05200	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6F57_RS05210	COG0849	cell division
A6F57_RS05215	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6F57_RS05220	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6F57_RS05225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6F57_RS05235	COG0772	Belongs to the SEDS family
A6F57_RS05240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6F57_RS05250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6F57_RS05255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6F57_RS05260	COG0768	penicillin binding
A6F57_RS05265	COG3116	cell division
A6F57_RS05275	COG2001	Belongs to the MraZ family
A6F57_RS05315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6F57_RS05315	COG0678	peroxiredoxin activity
A6F57_RS05330	COG2204	response regulator
A6F57_RS05335	COG2198	Histidine kinase
A6F57_RS05335	COG0784	Response regulator, receiver
A6F57_RS05335	COG5002	protein histidine kinase activity
A6F57_RS05355	COG0668	transmembrane transport
A6F57_RS05360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6F57_RS05365	COG0189	ligase activity
A6F57_RS05370	COG1678	Uncharacterized ACR, COG1678
A6F57_RS05375	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6F57_RS05395	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6F57_RS05400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6F57_RS05405	COG0762	integral membrane protein
A6F57_RS05420	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6F57_RS05420	COG1902	pentaerythritol trinitrate reductase activity
A6F57_RS05435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F57_RS05440	COG0625	glutathione transferase activity
A6F57_RS05470	COG0083	homoserine kinase activity
A6F57_RS05480	COG0583	DNA-binding transcription factor activity
A6F57_RS05490	COG2197	response regulator
A6F57_RS05495	COG4585	Histidine kinase
A6F57_RS05515	COG0640	Transcriptional regulator
A6F57_RS05525	COG0431	NADPH-dependent FMN reductase
A6F57_RS05530	COG0798	PFAM Bile acid sodium symporter
A6F57_RS05535	COG2201	protein-glutamate methylesterase activity
A6F57_RS05540	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A6F57_RS05545	COG0745	RESPONSE REGULATOR receiver
A6F57_RS05550	COG5002	protein histidine kinase activity
A6F57_RS05575	COG1748	Saccharopine dehydrogenase
A6F57_RS05590	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6F57_RS05595	COG3107	peptidoglycan biosynthetic process
A6F57_RS05600	COG0792	nuclease activity
A6F57_RS05610	COG2823	Periplasmic or secreted lipoprotein
A6F57_RS05640	COG4585	Histidine kinase
A6F57_RS05645	COG2197	response regulator
A6F57_RS05650	COG4771	TonB-dependent receptor
A6F57_RS05660	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A6F57_RS05665	COG0372	Belongs to the citrate synthase family
A6F57_RS05680	COG2199	diguanylate cyclase activity
A6F57_RS05680	COG2203	Gaf domain
A6F57_RS05705	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
A6F57_RS05725	COG5002	protein histidine kinase activity
A6F57_RS05725	COG0784	Response regulator, receiver
A6F57_RS05725	COG2198	Histidine kinase
A6F57_RS05730	COG0069	glutamate synthase activity
A6F57_RS05730	COG0070	glutamate synthase
A6F57_RS05730	COG0067	glutamate synthase
A6F57_RS05735	COG0493	'glutamate synthase
A6F57_RS05745	COG1476	TRANSCRIPTIONal
A6F57_RS05785	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6F57_RS05795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6F57_RS05800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6F57_RS05815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6F57_RS05820	COG0739	heme binding
A6F57_RS05825	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A6F57_RS05835	COG0738	Major facilitator superfamily
A6F57_RS05845	COG1902	pentaerythritol trinitrate reductase activity
A6F57_RS05855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6F57_RS05860	COG0625	glutathione transferase activity
A6F57_RS05880	COG2894	cell division
A6F57_RS05885	COG0850	regulation of cytokinetic process
A6F57_RS05910	COG1981	membrane
A6F57_RS05925	COG1914	H( )-stimulated, divalent metal cation uptake system
A6F57_RS05930	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6F57_RS05945	COG1217	gtp-binding protein TYPA
A6F57_RS05950	COG0174	glutamine synthetase
A6F57_RS05960	COG3852	Histidine kinase
A6F57_RS05970	COG3437	response regulator, receiver
A6F57_RS06005	COG0525	valine-tRNA ligase activity
A6F57_RS06010	COG2927	DNA polymerase III (CHI subunit)
A6F57_RS06015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6F57_RS06020	COG0795	lipopolysaccharide-transporting ATPase activity
A6F57_RS06025	COG0795	lipopolysaccharide-transporting ATPase activity
A6F57_RS06090	COG1082	Xylose isomerase domain protein TIM barrel
A6F57_RS06130	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A6F57_RS06145	COG0251	oxidation-reduction process
A6F57_RS06200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6F57_RS06210	COG0395	ABC-type sugar transport system, permease component
A6F57_RS06230	COG3706	GGDEF domain
A6F57_RS06235	COG3706	GGDEF domain
A6F57_RS06275	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6F57_RS06280	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6F57_RS06285	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A6F57_RS06295	COG0535	radical SAM domain protein
A6F57_RS06325	COG0784	Response regulator, receiver
A6F57_RS06325	COG2205	protein histidine kinase activity
A6F57_RS06335	COG0348	domain, Protein
A6F57_RS06335	COG3901	Regulator of nitric oxide reductase transcription
A6F57_RS06345	COG2197	response regulator
A6F57_RS06350	COG4585	Histidine kinase
A6F57_RS06380	COG4771	TonB-dependent receptor
A6F57_RS06385	COG1858	cytochrome C peroxidase
A6F57_RS06415	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_RS06425	COG1917	Cupin 2, conserved barrel domain protein
A6F57_RS06430	COG2271	Major facilitator Superfamily
A6F57_RS06450	COG1716	ATPase activity
A6F57_RS06485	COG1357	PFAM Pentapeptide repeats (8 copies)
A6F57_RS06485	COG0515	serine threonine protein kinase
A6F57_RS06505	COG1716	ATPase activity
A6F57_RS06505	COG1131	(ABC) transporter
A6F57_RS06505	COG0842	Transport permease protein
A6F57_RS06515	COG0513	Belongs to the DEAD box helicase family
A6F57_RS06520	COG0800	Aldolase
A6F57_RS06525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F57_RS06530	COG2186	Transcriptional regulator
A6F57_RS06540	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6F57_RS06540	COG3264	Mechanosensitive ion channel
A6F57_RS06575	COG3568	Endonuclease Exonuclease Phosphatase
A6F57_RS06590	COG0730	response to heat
A6F57_RS06595	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6F57_RS06610	COG4191	Histidine kinase
A6F57_RS06620	COG0417	DNA replication proofreading
A6F57_RS06675	COG1309	transcriptional regulator
A6F57_RS06690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6F57_RS06700	COG1573	uracil-dna glycosylase
A6F57_RS06705	COG3300	MHYT domain
A6F57_RS06705	COG5001	Diguanylate cyclase
A6F57_RS06725	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6F57_RS06730	COG4771	TonB-dependent receptor
A6F57_RS06755	COG1842	Phage shock protein A
A6F57_RS06765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6F57_RS06790	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6F57_RS06795	COG0204	Acyl-transferase
A6F57_RS06800	COG0204	Acyl-transferase
A6F57_RS06805	COG0668	transmembrane transport
A6F57_RS06820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6F57_RS06825	COG0733	neurotransmitter:sodium symporter activity
A6F57_RS06840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F57_RS06865	COG0848	biopolymer transport protein
A6F57_RS06875	COG0457	Tetratricopeptide repeat
A6F57_RS06905	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6F57_RS06910	COG0702	epimerase
A6F57_RS06925	COG5001	Diguanylate cyclase
A6F57_RS06925	COG5002	protein histidine kinase activity
A6F57_RS06935	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A6F57_RS06940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F57_RS06950	COG0583	DNA-binding transcription factor activity
A6F57_RS06955	COG0121	glutamine amidotransferase
A6F57_RS06970	COG1522	sequence-specific DNA binding
A6F57_RS06975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F57_RS06985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6F57_RS06995	COG1477	protein flavinylation
A6F57_RS07000	COG2871	sodium ion transport
A6F57_RS07005	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6F57_RS07010	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6F57_RS07015	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6F57_RS07020	COG1805	sodium ion transport
A6F57_RS07025	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6F57_RS07030	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6F57_RS07035	COG0545	Peptidyl-prolyl cis-trans isomerase
A6F57_RS07040	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6F57_RS07060	COG0039	L-malate dehydrogenase activity
A6F57_RS07065	COG1438	arginine binding
A6F57_RS07095	COG0572	uridine kinase
A6F57_RS07100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6F57_RS07110	COG0457	Tetratricopeptide repeat
A6F57_RS07115	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6F57_RS07140	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F57_RS07160	COG0189	ligase activity
A6F57_RS07170	COG0189	ligase activity
A6F57_RS07170	COG4067	protein conserved in archaea
A6F57_RS07185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6F57_RS07200	COG1283	sodium-dependent phosphate transmembrane transporter activity
A6F57_RS07205	COG0667	Aldo Keto reductase
A6F57_RS07220	COG0753	catalase activity
A6F57_RS07255	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A6F57_RS07260	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6F57_RS07260	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6F57_RS07265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6F57_RS07325	COG0583	DNA-binding transcription factor activity
A6F57_RS07335	COG0438	transferase activity, transferring glycosyl groups
A6F57_RS07335	COG1216	Glycosyl transferase, family 2
A6F57_RS07405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6F57_RS07410	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A6F57_RS07420	COG1083	cytidylyl-transferase
A6F57_RS07460	COG1216	Glycosyl transferase, family 2
A6F57_RS07460	COG0463	Glycosyl transferase, family 2
A6F57_RS07485	COG0662	Cupin 2, conserved barrel domain protein
A6F57_RS07485	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A6F57_RS07495	COG0202	RNA polymerase activity
A6F57_RS07515	COG0201	protein transport
A6F57_RS07535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6F57_RS07570	COG5002	protein histidine kinase activity
A6F57_RS07570	COG0784	Response regulator, receiver
A6F57_RS07585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6F57_RS07590	COG0557	exoribonuclease II activity
A6F57_RS07605	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A6F57_RS07620	COG0543	2 iron, 2 sulfur cluster binding
A6F57_RS07625	COG2234	aminopeptidase activity
A6F57_RS07645	COG1271	oxidase subunit
A6F57_RS07650	COG1294	oxidase, subunit
A6F57_RS07655	COG0840	transmembrane signaling receptor activity
A6F57_RS07660	COG1522	sequence-specific DNA binding
A6F57_RS07675	COG1278	Cold shock
A6F57_RS07680	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6F57_RS07700	COG0339	signal peptide processing
A6F57_RS07705	COG2201	protein-glutamate methylesterase activity
A6F57_RS07725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6F57_RS07730	COG0243	molybdopterin cofactor binding
A6F57_RS07735	COG0793	Belongs to the peptidase S41A family
A6F57_RS07735	COG4946	Tricorn protease homolog
A6F57_RS07775	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6F57_RS07780	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6F57_RS07785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6F57_RS07800	COG0281	malic enzyme
A6F57_RS07805	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
A6F57_RS07810	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6F57_RS07840	COG0456	acetyltransferase
A6F57_RS07850	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6F57_RS07855	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6F57_RS07860	COG2177	Part of the ABC transporter FtsEX involved in
A6F57_RS07865	COG2884	Cell division ATP-binding protein ftsE
A6F57_RS07870	COG0552	protein localization to endoplasmic reticulum
A6F57_RS07885	COG2095	MarC family integral membrane protein
A6F57_RS07905	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6F57_RS07910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F57_RS07920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6F57_RS07935	COG0076	glutamate decarboxylase activity
A6F57_RS07940	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A6F57_RS07950	COG0842	Transport permease protein
A6F57_RS07955	COG1131	(ABC) transporter
A6F57_RS07960	COG0745	RESPONSE REGULATOR receiver
A6F57_RS07965	COG2205	protein histidine kinase activity
A6F57_RS07970	COG4774	siderophore transport
A6F57_RS07990	COG1253	flavin adenine dinucleotide binding
A6F57_RS07995	COG0701	Predicted permease
A6F57_RS08000	COG1966	Carbon starvation protein
A6F57_RS08015	COG0657	acetylesterase activity
A6F57_RS08055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6F57_RS08060	COG0049	tRNA binding
A6F57_RS08065	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6F57_RS08070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6F57_RS08075	COG0085	RNA polymerase activity
A6F57_RS08080	COG0222	ribosome binding
A6F57_RS08085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6F57_RS08090	COG0081	regulation of translation
A6F57_RS08095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6F57_RS08100	COG0250	Participates in transcription elongation, termination and antitermination
A6F57_RS08105	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6F57_RS08115	COG1132	(ABC) transporter
A6F57_RS08120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6F57_RS08125	COG3590	peptidase
A6F57_RS08135	COG0513	Belongs to the DEAD box helicase family
A6F57_RS08140	COG0418	dihydroorotase activity
A6F57_RS08150	COG3040	lipid binding
A6F57_RS08155	COG4989	oxidoreductase activity
A6F57_RS08160	COG0346	lactoylglutathione lyase activity
A6F57_RS08175	COG0302	gtp cyclohydrolase
A6F57_RS08195	COG2957	Belongs to the agmatine deiminase family
A6F57_RS08200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F57_RS08215	COG3306	glycosyltransferase involved in LPS biosynthesis
A6F57_RS08220	COG1201	RNA secondary structure unwinding
A6F57_RS08230	COG1793	dna ligase
A6F57_RS08240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F57_RS08255	COG0625	glutathione transferase activity
A6F57_RS08270	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A6F57_RS08275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6F57_RS08285	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_RS08300	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6F57_RS08305	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6F57_RS08310	COG0330	HflC and HflK could
A6F57_RS08315	COG0330	HflC and HflK could
A6F57_RS08320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6F57_RS08325	COG1923	regulation of RNA biosynthetic process
A6F57_RS08330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6F57_RS08345	COG0802	atpase or kinase
A6F57_RS08350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6F57_RS08350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6F57_RS08355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6F57_RS08370	COG2816	NAD+ diphosphatase activity
A6F57_RS08375	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
A6F57_RS08380	COG0735	belongs to the Fur family
A6F57_RS08425	COG2258	MOSC domain
A6F57_RS08455	COG5002	protein histidine kinase activity
A6F57_RS08465	COG0840	transmembrane signaling receptor activity
A6F57_RS08470	COG4191	Histidine kinase
A6F57_RS08470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6F57_RS08480	COG1609	Transcriptional regulator
A6F57_RS08485	COG2211	Major facilitator Superfamily
A6F57_RS08490	COG2723	6-phospho-beta-galactosidase activity
A6F57_RS08500	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6F57_RS08505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6F57_RS08510	COG4558	Periplasmic binding protein
A6F57_RS08520	COG4206	TonB-dependent receptor
A6F57_RS08530	COG1472	Belongs to the glycosyl hydrolase 3 family
A6F57_RS08545	COG2855	membrane
A6F57_RS08550	COG2175	clavaminate synthase activity
A6F57_RS08555	COG0656	L-ascorbic acid biosynthetic process
A6F57_RS08560	COG2188	Transcriptional regulator
A6F57_RS08575	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F57_RS08580	COG1230	cation diffusion facilitator family transporter
A6F57_RS08615	COG4771	TonB-dependent receptor
A6F57_RS08620	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6F57_RS08625	COG4988	ABC transporter
A6F57_RS08635	COG1294	oxidase, subunit
A6F57_RS08650	COG2204	response regulator
A6F57_RS08685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6F57_RS08710	COG4319	ketosteroid isomerase
A6F57_RS08750	COG3237	CsbD-like
A6F57_RS08770	COG1404	Belongs to the peptidase S8 family
A6F57_RS08795	COG2267	carboxylic ester hydrolase activity
A6F57_RS08820	COG3038	cytochrome b561
A6F57_RS08825	COG2353	YceI-like domain
A6F57_RS08830	COG1252	NADH dehydrogenase
A6F57_RS08855	COG2067	long-chain fatty acid transport protein
A6F57_RS08860	COG2130	NADP-dependent
A6F57_RS08865	COG5001	Diguanylate cyclase
A6F57_RS08865	COG4251	negative regulation of phosphorylation
A6F57_RS08865	COG3706	GGDEF domain
A6F57_RS08865	COG2203	Gaf domain
A6F57_RS08885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6F57_RS08895	COG4181	ATPase activity
A6F57_RS08915	COG0523	cobalamin synthesis protein
A6F57_RS08930	COG4771	TonB-dependent receptor
A6F57_RS08995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6F57_RS09000	COG1349	DNA-binding transcription factor activity
A6F57_RS09015	COG0697	spore germination
A6F57_RS09020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6F57_RS09025	COG4977	sequence-specific DNA binding
A6F57_RS09035	COG1166	arginine decarboxylase activity
A6F57_RS09045	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6F57_RS09065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6F57_RS09075	COG0523	cobalamin synthesis protein
A6F57_RS09105	COG4232	protein-disulfide reductase activity
A6F57_RS09110	COG0739	heme binding
A6F57_RS09115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6F57_RS09120	COG0511	ligase activity, forming carbon-carbon bonds
A6F57_RS09125	COG0439	Biotin carboxylase
A6F57_RS09145	COG2176	DNA-directed DNA polymerase activity
A6F57_RS09165	COG0154	amidase activity
A6F57_RS09180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6F57_RS09185	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A6F57_RS09200	COG0151	Belongs to the GarS family
A6F57_RS09210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6F57_RS09220	COG3954	Phosphoribulokinase
A6F57_RS09225	COG2233	PERMEase
A6F57_RS09255	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6F57_RS09260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6F57_RS09270	COG3031	protein transport across the cell outer membrane
A6F57_RS09280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6F57_RS09285	COG1459	type II secretion system
A6F57_RS09290	COG2165	general secretion pathway protein
A6F57_RS09300	COG2165	general secretion pathway protein
A6F57_RS09305	COG4795	General secretion pathway protein
A6F57_RS09320	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6F57_RS09330	COG1234	tRNA 3'-trailer cleavage
A6F57_RS09335	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_RS09345	COG1011	Hydrolase
A6F57_RS09350	COG0494	nUDIX hydrolase
A6F57_RS09355	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6F57_RS09365	COG2943	transferase activity, transferring hexosyl groups
A6F57_RS09370	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A6F57_RS09380	COG3089	Belongs to the UPF0270 family
A6F57_RS09385	COG0429	hydrolase of the alpha beta-hydrolase fold
A6F57_RS09395	COG0488	(ABC) transporter
A6F57_RS09420	COG0545	Peptidyl-prolyl cis-trans isomerase
A6F57_RS09430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6F57_RS09435	COG2183	response to ionizing radiation
A6F57_RS09450	COG0596	Alpha beta hydrolase
A6F57_RS09455	COG1040	competence protein
A6F57_RS09475	COG1794	racemase activity, acting on amino acids and derivatives
A6F57_RS09490	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A6F57_RS09495	COG0534	Mate efflux family protein
A6F57_RS09510	COG1999	signal sequence binding
A6F57_RS09515	COG0109	protoheme IX farnesyltransferase activity
A6F57_RS09520	COG1612	heme a metabolic process
A6F57_RS09545	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A6F57_RS09550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6F57_RS09555	COG1565	acr, cog1565
A6F57_RS09555	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6F57_RS09585	COG0129	dihydroxy-acid dehydratase activity
A6F57_RS09615	COG2814	Major facilitator Superfamily
A6F57_RS09625	COG0729	surface antigen
A6F57_RS09630	COG2911	Protein conserved in bacteria
A6F57_RS09655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6F57_RS09665	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6F57_RS09685	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6F57_RS09735	COG0425	Belongs to the sulfur carrier protein TusA family
A6F57_RS09750	COG1561	YicC-like family, N-terminal region
A6F57_RS09785	COG2211	Major facilitator Superfamily
A6F57_RS09790	COG1609	Transcriptional regulator
A6F57_RS09805	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A6F57_RS09805	COG2199	diguanylate cyclase activity
A6F57_RS09835	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6F57_RS09855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6F57_RS09860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6F57_RS09880	COG1475	DNA binding
A6F57_RS09885	COG1192	Involved in chromosome partitioning
A6F57_RS09910	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6F57_RS09915	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6F57_RS09925	COG0706	membrane insertase activity
A6F57_RS09930	COG0594	ribonuclease P activity
A6F57_RS09935	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6F57_RS09950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6F57_RS09955	COG0187	DNA topoisomerase II activity
A6F57_RS09980	COG2818	Glycosylase
A6F57_RS09990	COG3078	GTPase activator activity
A6F57_RS10005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6F57_RS10005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6F57_RS10010	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A6F57_RS10015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6F57_RS10020	COG0569	domain protein
A6F57_RS10025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6F57_RS10025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6F57_RS10045	COG0758	DNA mediated transformation
A6F57_RS10060	COG0009	L-threonylcarbamoyladenylate synthase
A6F57_RS10065	COG0408	coproporphyrinogen oxidase activity
A6F57_RS10070	COG3047	cAMP biosynthetic process
A6F57_RS10085	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6F57_RS10170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6F57_RS10190	COG2234	aminopeptidase activity
A6F57_RS10205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6F57_RS10230	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6F57_RS10270	COG3642	lipopolysaccharide core region biosynthetic process
A6F57_RS10275	COG0859	PFAM glycosyl transferase family 9
A6F57_RS10295	COG0156	8-amino-7-oxononanoate synthase activity
A6F57_RS10305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6F57_RS10310	COG0705	Rhomboid family
A6F57_RS10320	COG3161	chorismate lyase activity
A6F57_RS10325	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6F57_RS10330	COG2960	long-chain fatty acid transporting porin activity
A6F57_RS10335	COG0210	DNA helicase
A6F57_RS10395	COG0582	viral genome integration into host DNA
A6F57_RS10400	COG1757	Na H antiporter
A6F57_RS10450	COG1715	Restriction endonuclease
A6F57_RS10455	COG1674	ftsk spoiiie
A6F57_RS10470	COG1620	l-lactate permease
A6F57_RS10485	COG2181	nitrate reductase activity
A6F57_RS10485	COG0247	lactate metabolic process
A6F57_RS10490	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6F57_RS10490	COG1902	pentaerythritol trinitrate reductase activity
A6F57_RS10510	COG4638	Rieske (2fe-2S)
A6F57_RS10525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6F57_RS10565	COG1760	l-serine dehydratase
A6F57_RS10570	COG0583	DNA-binding transcription factor activity
A6F57_RS10585	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_RS10590	COG4948	Mandelate Racemase Muconate Lactonizing
A6F57_RS10600	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_RS10605	COG4771	TonB-dependent receptor
A6F57_RS10610	COG0457	Tetratricopeptide repeat
A6F57_RS10615	COG3850	Histidine kinase
A6F57_RS10615	COG2205	protein histidine kinase activity
A6F57_RS10615	COG4999	Histidine kinase
A6F57_RS10615	COG3437	response regulator, receiver
A6F57_RS10620	COG4773	Receptor
A6F57_RS10625	COG0583	DNA-binding transcription factor activity
A6F57_RS10640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F57_RS10645	COG0842	Transport permease protein
A6F57_RS10645	COG1129	ABC transporter
A6F57_RS10650	COG0842	Transport permease protein
A6F57_RS10660	COG1960	acyl-CoA dehydrogenase activity
A6F57_RS10665	COG0583	DNA-binding transcription factor activity
A6F57_RS10680	COG3106	COG3106 Predicted ATPase
A6F57_RS10700	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6F57_RS10715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6F57_RS10730	COG4771	TonB-dependent receptor
A6F57_RS10735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6F57_RS10745	COG0778	Nitroreductase
A6F57_RS10745	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A6F57_RS10755	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6F57_RS10760	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6F57_RS10765	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6F57_RS10770	COG1309	transcriptional regulator
A6F57_RS10805	COG3071	HemY protein
A6F57_RS10810	COG2959	enzyme of heme biosynthesis
A6F57_RS10820	COG0181	hydroxymethylbilane synthase activity
A6F57_RS10835	COG0194	GDP metabolic process
A6F57_RS10845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6F57_RS10855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6F57_RS10860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6F57_RS10870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6F57_RS10870	COG0678	peroxiredoxin activity
A6F57_RS10890	COG1178	ABC-type Fe3 transport system permease component
A6F57_RS10895	COG3842	ATPase activity
A6F57_RS10900	COG3300	MHYT domain
A6F57_RS10900	COG5001	Diguanylate cyclase
A6F57_RS10910	COG2081	HI0933 family
A6F57_RS10915	COG0668	transmembrane transport
A6F57_RS10940	COG5002	protein histidine kinase activity
A6F57_RS10940	COG5001	Diguanylate cyclase
A6F57_RS10940	COG3447	MASE1 domain protein
A6F57_RS10950	COG0583	DNA-binding transcription factor activity
A6F57_RS10975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F57_RS10980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6F57_RS10990	COG0427	acetyl-CoA hydrolase
A6F57_RS10995	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6F57_RS11005	COG0840	transmembrane signaling receptor activity
A6F57_RS11015	COG3064	Membrane
A6F57_RS11020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6F57_RS11025	COG5002	protein histidine kinase activity
A6F57_RS11025	COG5001	Diguanylate cyclase
A6F57_RS11035	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6F57_RS11045	COG0514	ATP-dependent DNA helicase (RecQ)
A6F57_RS11050	COG2050	protein possibly involved in aromatic compounds catabolism
A6F57_RS11055	COG2239	Acts as a magnesium transporter
A6F57_RS11060	COG2962	Rard protein
A6F57_RS11080	COG1011	Hydrolase
A6F57_RS11095	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6F57_RS11100	COG0019	diaminopimelate decarboxylase activity
A6F57_RS11130	COG0163	prenyltransferase activity
A6F57_RS11135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6F57_RS11145	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6F57_RS11170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6F57_RS11175	COG2814	Major facilitator Superfamily
A6F57_RS11180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6F57_RS11200	COG1085	galactose-1-phosphate uridylyltransferase
A6F57_RS11205	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6F57_RS11215	COG0629	single-stranded DNA binding
A6F57_RS11230	COG0745	RESPONSE REGULATOR receiver
A6F57_RS11240	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6F57_RS11270	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F57_RS11295	COG1349	DNA-binding transcription factor activity
A6F57_RS11335	COG3267	Type II secretory pathway component ExeA
A6F57_RS11335	COG3409	Peptidoglycan-binding domain 1 protein
A6F57_RS11345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6F57_RS11350	COG1459	type II secretion system
A6F57_RS11360	COG2165	general secretion pathway protein
A6F57_RS11365	COG2165	general secretion pathway protein
A6F57_RS11390	COG1077	Cell shape determining protein MreB Mrl
A6F57_RS11395	COG1792	Involved in formation and maintenance of cell shape
A6F57_RS11400	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A6F57_RS11410	COG1530	ribonuclease E activity
A6F57_RS11420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F57_RS11425	COG0312	modulator of DNA gyrase
A6F57_RS11435	COG3028	Belongs to the UPF0307 family
A6F57_RS11440	COG0312	modulator of DNA gyrase
A6F57_RS11455	COG0745	RESPONSE REGULATOR receiver
A6F57_RS11460	COG4191	Histidine kinase
A6F57_RS11460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6F57_RS11465	COG0297	glycogen (starch) synthase activity
A6F57_RS11475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6F57_RS11485	COG1194	a g-specific adenine glycosylase
A6F57_RS11535	COG0745	RESPONSE REGULATOR receiver
A6F57_RS11545	COG0835	chemotaxis
A6F57_RS11560	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A6F57_RS11565	COG2201	protein-glutamate methylesterase activity
A6F57_RS11580	COG0501	Belongs to the peptidase M48B family
A6F57_RS11640	COG1609	Transcriptional regulator
A6F57_RS11645	COG0673	inositol 2-dehydrogenase activity
A6F57_RS11690	COG1454	alcohol dehydrogenase
A6F57_RS11710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6F57_RS11715	COG0051	transcription antitermination factor activity, RNA binding
A6F57_RS11730	COG0089	rRNA binding
A6F57_RS11740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6F57_RS11750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6F57_RS11765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6F57_RS11770	COG0438	transferase activity, transferring glycosyl groups
A6F57_RS11775	COG0859	PFAM glycosyl transferase family 9
A6F57_RS11780	COG1519	Transferase
A6F57_RS11805	COG0339	signal peptide processing
A6F57_RS11815	COG0788	formyltetrahydrofolate deformylase activity
A6F57_RS11825	COG1643	Atp-dependent helicase
A6F57_RS11830	COG2951	lytic endotransglycosylase activity
A6F57_RS11840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6F57_RS11850	COG2354	Protein conserved in bacteria
A6F57_RS11875	COG0004	ammonium transporteR
A6F57_RS11880	COG0405	Gamma-glutamyltransferase
A6F57_RS11885	COG2837	iron assimilation
A6F57_RS11900	COG0540	Belongs to the ATCase OTCase family
A6F57_RS11925	COG2205	protein histidine kinase activity
A6F57_RS11925	COG3437	response regulator, receiver
A6F57_RS11925	COG4999	Histidine kinase
A6F57_RS11925	COG3850	Histidine kinase
A6F57_RS11950	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_RS11960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6F57_RS11970	COG0512	Glutamine amidotransferase of anthranilate synthase
A6F57_RS11975	COG0180	Tryptophanyl-tRNA synthetase
A6F57_RS11980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6F57_RS12000	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A6F57_RS12010	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6F57_RS12045	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6F57_RS12050	COG0281	malic enzyme
A6F57_RS12055	COG0625	glutathione transferase activity
A6F57_RS12095	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6F57_RS12095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6F57_RS12105	COG0137	argininosuccinate synthase activity
A6F57_RS12110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6F57_RS12125	COG1803	Methylglyoxal synthase
A6F57_RS12135	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6F57_RS12150	COG0745	RESPONSE REGULATOR receiver
A6F57_RS12155	COG2205	protein histidine kinase activity
A6F57_RS12165	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6F57_RS12180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6F57_RS12190	COG4942	peptidase
A6F57_RS12200	COG2861	carbohydrate metabolic process
A6F57_RS12210	COG0584	glycerophosphoryl diester phosphodiesterase
A6F57_RS12225	COG1162	GTPase activity
A6F57_RS12230	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A6F57_RS12250	COG0457	Tetratricopeptide repeat
A6F57_RS12265	COG0028	Belongs to the TPP enzyme family
A6F57_RS12285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6F57_RS12290	COG0805	protein transport
A6F57_RS12315	COG0248	Ppx GppA phosphatase
A6F57_RS12320	COG0513	Belongs to the DEAD box helicase family
A6F57_RS12325	COG3118	belongs to the thioredoxin family
A6F57_RS12330	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6F57_RS12335	COG1473	amidohydrolase
A6F57_RS12340	COG2205	protein histidine kinase activity
A6F57_RS12340	COG0784	Response regulator, receiver
A6F57_RS12345	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6F57_RS12350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6F57_RS12355	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6F57_RS12370	COG0783	Belongs to the Dps family
A6F57_RS12375	COG2133	pyrroloquinoline quinone binding
A6F57_RS12385	COG3118	belongs to the thioredoxin family
A6F57_RS12395	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A6F57_RS12405	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_RS12420	COG1757	Na H antiporter
A6F57_RS12440	COG3876	Protein conserved in bacteria
A6F57_RS12445	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6F57_RS12465	COG0346	lactoylglutathione lyase activity
A6F57_RS12535	COG4115	mRNA cleavage
A6F57_RS12540	COG2161	toxin-antitoxin pair type II binding
A6F57_RS12625	COG0183	Belongs to the thiolase family
A6F57_RS12630	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6F57_RS12630	COG1024	Enoyl-CoA hydratase
A6F57_RS12640	COG0006	proline dipeptidase activity
A6F57_RS12650	COG0142	geranyltranstransferase activity
A6F57_RS12710	COG1238	metal cluster binding
A6F57_RS12720	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6F57_RS12725	COG0585	pseudouridine synthase activity
A6F57_RS12740	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A6F57_RS12750	COG0840	transmembrane signaling receptor activity
A6F57_RS12755	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A6F57_RS12755	COG0506	proline dehydrogenase activity
A6F57_RS12755	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A6F57_RS12770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6F57_RS12785	COG4991	sh3 domain protein
A6F57_RS12790	COG3025	triphosphatase activity
A6F57_RS12805	COG0494	nUDIX hydrolase
A6F57_RS12810	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
A6F57_RS12815	COG0730	response to heat
A6F57_RS12820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6F57_RS12825	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6F57_RS12830	COG2201	protein-glutamate methylesterase activity
A6F57_RS12835	COG3706	GGDEF domain
A6F57_RS12840	COG5002	protein histidine kinase activity
A6F57_RS12840	COG0784	Response regulator, receiver
A6F57_RS12860	COG0564	pseudouridine synthase activity
A6F57_RS12870	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A6F57_RS12880	COG1802	Transcriptional regulator
A6F57_RS12885	COG3119	arylsulfatase activity
A6F57_RS12890	COG1012	belongs to the aldehyde dehydrogenase family
A6F57_RS12895	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_RS12900	COG1063	alcohol dehydrogenase
A6F57_RS12910	COG2814	Major facilitator Superfamily
A6F57_RS12915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F57_RS12930	COG2124	cytochrome p450
A6F57_RS13025	COG3119	arylsulfatase activity
A6F57_RS13065	COG3119	arylsulfatase activity
A6F57_RS13075	COG1648	precorrin-2 dehydrogenase activity
A6F57_RS13075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6F57_RS13095	COG1538	Outer membrane efflux protein
A6F57_RS13100	COG0494	nUDIX hydrolase
A6F57_RS13115	COG3150	esterase
A6F57_RS13130	COG4251	negative regulation of phosphorylation
A6F57_RS13135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6F57_RS13155	COG1509	lysine 2,3-aminomutase activity
A6F57_RS13160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6F57_RS13185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6F57_RS13200	COG0271	Belongs to the BolA IbaG family
A6F57_RS13205	COG0671	phosphoesterase, PA-phosphatase related
A6F57_RS13215	COG3707	response regulator
A6F57_RS13225	COG0659	secondary active sulfate transmembrane transporter activity
A6F57_RS13230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6F57_RS13235	COG2146	nitrite reductase [NAD(P)H] activity
A6F57_RS13240	COG0243	molybdopterin cofactor binding
A6F57_RS13245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6F57_RS13245	COG1648	precorrin-2 dehydrogenase activity
A6F57_RS13260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6F57_RS13260	COG1116	anion transmembrane transporter activity
A6F57_RS13265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6F57_RS13270	COG1116	anion transmembrane transporter activity
A6F57_RS13285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6F57_RS13290	COG4206	TonB-dependent receptor
A6F57_RS13295	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6F57_RS13300	COG0348	domain, Protein
A6F57_RS13315	COG1960	acyl-CoA dehydrogenase activity
A6F57_RS13320	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_RS13340	COG4948	Mandelate Racemase Muconate Lactonizing
A6F57_RS13355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F57_RS13360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6F57_RS13385	COG0358	DNA primase activity
A6F57_RS13390	COG1610	YqeY-like protein
A6F57_RS13410	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6F57_RS13415	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6F57_RS13430	COG0537	adenosine 5'-monophosphoramidase activity
A6F57_RS13445	COG3135	benzoate transporter
A6F57_RS13450	COG1396	sequence-specific DNA binding
A6F57_RS13455	COG2974	May be involved in recombination
A6F57_RS13460	COG4191	Histidine kinase
A6F57_RS13460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6F57_RS13465	COG0745	RESPONSE REGULATOR receiver
A6F57_RS13470	COG5002	protein histidine kinase activity
A6F57_RS13500	COG0811	peptide transport
A6F57_RS13505	COG0811	peptide transport
A6F57_RS13510	COG0848	biopolymer transport protein
A6F57_RS13515	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A6F57_RS13525	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6F57_RS13530	COG3437	response regulator, receiver
A6F57_RS13550	COG2133	pyrroloquinoline quinone binding
A6F57_RS13555	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6F57_RS13575	COG0527	aspartate kinase activity
A6F57_RS13580	COG0840	transmembrane signaling receptor activity
A6F57_RS13585	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6F57_RS13595	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6F57_RS13600	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6F57_RS13605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6F57_RS13610	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6F57_RS13615	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6F57_RS13625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6F57_RS13645	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6F57_RS13655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6F57_RS13660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6F57_RS13665	COG3956	TIGRFAM MazG family protein
A6F57_RS13685	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6F57_RS13690	COG1595	DNA-templated transcription, initiation
A6F57_RS13700	COG4206	TonB-dependent receptor
A6F57_RS13710	COG1473	amidohydrolase
A6F57_RS13715	COG0723	plastoquinol--plastocyanin reductase activity
A6F57_RS13720	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6F57_RS13725	COG2857	Cytochrome c1
A6F57_RS13730	COG0625	glutathione transferase activity
A6F57_RS13735	COG2969	positive regulation of protein catabolic process
A6F57_RS13740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F57_RS13740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F57_RS13755	COG2239	Acts as a magnesium transporter
A6F57_RS13760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6F57_RS13780	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A6F57_RS13785	COG1137	ATPase activity
A6F57_RS13800	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6F57_RS13815	COG1127	ABC transporter
A6F57_RS13820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6F57_RS13825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6F57_RS13830	COG2854	intermembrane phospholipid transfer
A6F57_RS13840	COG5007	Belongs to the BolA IbaG family
A6F57_RS13850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6F57_RS13855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6F57_RS13865	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6F57_RS13880	COG2207	Transcriptional regulator
A6F57_RS13895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6F57_RS13910	COG3300	MHYT domain
A6F57_RS13910	COG5001	Diguanylate cyclase
A6F57_RS13915	COG2205	protein histidine kinase activity
A6F57_RS13915	COG0784	Response regulator, receiver
A6F57_RS13925	COG2207	Transcriptional regulator
A6F57_RS13930	COG1979	alcohol dehydrogenase
A6F57_RS13955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6F57_RS13965	COG0126	phosphoglycerate kinase activity
A6F57_RS13970	COG3588	fructose-bisphosphate aldolase
A6F57_RS13975	COG4946	Tricorn protease homolog
A6F57_RS13975	COG0823	Involved in the tonB-independent uptake of proteins
A6F57_RS13975	COG1506	peptidase
A6F57_RS13985	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6F57_RS13995	COG0573	inorganic phosphate transmembrane transporter activity
A6F57_RS14000	COG0581	inorganic phosphate transmembrane transporter activity
A6F57_RS14005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6F57_RS14015	COG0306	phosphate transporter
A6F57_RS14025	COG0583	DNA-binding transcription factor activity
A6F57_RS14050	COG1272	protein, Hemolysin III
A6F57_RS14070	COG0477	Major facilitator Superfamily
A6F57_RS14075	COG1609	Transcriptional regulator
A6F57_RS14075	COG2207	Transcriptional regulator
A6F57_RS14080	COG1070	Carbohydrate kinase
A6F57_RS14085	COG2115	Belongs to the xylose isomerase family
A6F57_RS14090	COG4447	cellulose binding
A6F57_RS14090	COG3291	Pkd domain containing protein
A6F57_RS14090	COG5520	Belongs to the glycosyl hydrolase 30 family
A6F57_RS14095	COG2207	Transcriptional regulator
A6F57_RS14110	COG1472	Belongs to the glycosyl hydrolase 3 family
A6F57_RS14115	COG1846	Transcriptional regulator
A6F57_RS14120	COG1764	response to oxidative stress
A6F57_RS14145	COG0420	3'-5' exonuclease activity
A6F57_RS14150	COG0419	ATPase involved in DNA repair
A6F57_RS14155	COG3706	GGDEF domain
A6F57_RS14165	COG2971	BadF BadG BcrA BcrD
A6F57_RS14170	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6F57_RS14175	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6F57_RS14180	COG0488	(ABC) transporter
A6F57_RS14215	COG4667	esterase of the alpha-beta hydrolase superfamily
A6F57_RS14285	COG1346	cytolysis
A6F57_RS14315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6F57_RS14325	COG0513	Belongs to the DEAD box helicase family
A6F57_RS14335	COG3409	Peptidoglycan-binding domain 1 protein
A6F57_RS14335	COG3267	Type II secretory pathway component ExeA
A6F57_RS14345	COG3437	response regulator, receiver
A6F57_RS14345	COG0784	Response regulator, receiver
A6F57_RS14350	COG0066	3-isopropylmalate dehydratase activity
A6F57_RS14360	COG0473	3-isopropylmalate dehydrogenase activity
A6F57_RS14365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6F57_RS14395	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6F57_RS14410	COG4555	ABC transporter
A6F57_RS14415	COG1668	transmembrane transport
A6F57_RS14435	COG4133	protoheme IX ABC transporter activity
A6F57_RS14440	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6F57_RS14445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6F57_RS14450	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6F57_RS14460	COG1138	Cytochrome C-type biogenesis protein
A6F57_RS14465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6F57_RS14480	COG2853	Lipoprotein
A6F57_RS14485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6F57_RS14510	COG1682	transport, permease protein
A6F57_RS14540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6F57_RS14545	COG1596	polysaccharide export
A6F57_RS14545	COG1555	photosystem II stabilization
A6F57_RS14550	COG0473	3-isopropylmalate dehydrogenase activity
A6F57_RS14565	COG1611	Belongs to the LOG family
A6F57_RS14575	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6F57_RS14575	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6F57_RS14645	COG0564	pseudouridine synthase activity
A6F57_RS14660	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A6F57_RS14665	COG0024	Methionine aminopeptidase
A6F57_RS14670	COG0052	Belongs to the universal ribosomal protein uS2 family
A6F57_RS14680	COG0528	UMP kinase activity
A6F57_RS14690	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6F57_RS14695	COG0575	Belongs to the CDS family
A6F57_RS14700	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6F57_RS14705	COG0750	zinc metalloprotease
A6F57_RS14720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6F57_RS14725	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6F57_RS14740	COG0587	DNA-directed DNA polymerase activity
A6F57_RS14745	COG0825	malonyl-CoA metabolic process
A6F57_RS14750	COG0037	tRNA processing
A6F57_RS14780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6F57_RS14780	COG0047	phosphoribosylformylglycinamidine synthase activity
A6F57_RS14785	COG2840	Smr protein MutS2
A6F57_RS14805	COG2885	chlorophyll binding
A6F57_RS14815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F57_RS14820	COG2197	response regulator
A6F57_RS14860	COG0784	Response regulator, receiver
A6F57_RS14860	COG0835	chemotaxis
A6F57_RS14865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6F57_RS14870	COG1815	bacterial-type flagellum-dependent cell motility
A6F57_RS14885	COG1749	Flagellar hook protein flgE
A6F57_RS14890	COG4787	bacterial-type flagellum-dependent cell motility
A6F57_RS14910	COG3951	Flagellar rod assembly protein muramidase FlgJ
A6F57_RS14910	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6F57_RS14915	COG1256	bacterial-type flagellum assembly
A6F57_RS14935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6F57_RS14940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6F57_RS14970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6F57_RS14975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6F57_RS14990	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6F57_RS15015	COG2089	acid synthase
A6F57_RS15030	COG1083	cytidylyl-transferase
A6F57_RS15045	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_RS15050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6F57_RS15065	COG2089	acid synthase
A6F57_RS15075	COG1083	cytidylyl-transferase
A6F57_RS15080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6F57_RS15085	COG1086	Polysaccharide biosynthesis protein
A6F57_RS15115	COG1766	The M ring may be actively involved in energy transduction
A6F57_RS15120	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6F57_RS15170	COG1987	bacterial-type flagellum assembly
A6F57_RS15185	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6F57_RS15210	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A6F57_RS15215	COG0643	Histidine kinase
A6F57_RS15215	COG2198	Histidine kinase
A6F57_RS15215	COG0784	Response regulator, receiver
A6F57_RS15220	COG2201	protein-glutamate methylesterase activity
A6F57_RS15225	COG1192	Involved in chromosome partitioning
A6F57_RS15235	COG0835	chemotaxis
A6F57_RS15250	COG1410	methionine synthase
A6F57_RS15250	COG0646	methionine synthase
A6F57_RS15265	COG0583	DNA-binding transcription factor activity
A6F57_RS15270	COG0583	DNA-binding transcription factor activity
A6F57_RS15275	COG0288	reversible hydration of carbon dioxide
A6F57_RS15280	COG0659	secondary active sulfate transmembrane transporter activity
A6F57_RS15290	COG1309	transcriptional regulator
A6F57_RS15295	COG3590	peptidase
A6F57_RS15310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6F57_RS15335	COG1607	acyl-coa hydrolase
A6F57_RS15350	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A6F57_RS15355	COG4172	Belongs to the ABC transporter superfamily
A6F57_RS15360	COG4172	Belongs to the ABC transporter superfamily
A6F57_RS15365	COG4171	peptide transport system, permease
A6F57_RS15370	COG4168	peptide transport system, permease
A6F57_RS15375	COG0747	negative chemotaxis
A6F57_RS15380	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6F57_RS15385	COG1842	Phage shock protein A
A6F57_RS15415	COG0625	glutathione transferase activity
A6F57_RS15420	COG1522	sequence-specific DNA binding
A6F57_RS15450	COG0457	Tetratricopeptide repeat
A6F57_RS15490	COG0811	peptide transport
A6F57_RS15495	COG0811	peptide transport
A6F57_RS15500	COG0848	biopolymer transport protein
A6F57_RS15555	COG0456	acetyltransferase
A6F57_RS15570	COG0583	DNA-binding transcription factor activity
A6F57_RS15600	COG2175	clavaminate synthase activity
A6F57_RS15625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6F57_RS15630	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6F57_RS15635	COG0564	pseudouridine synthase activity
A6F57_RS15645	COG0612	Peptidase, M16
A6F57_RS15650	COG2918	glutathione biosynthetic process
A6F57_RS15670	COG1136	(ABC) transporter
A6F57_RS15695	COG2840	Smr protein MutS2
A6F57_RS15700	COG2890	protein-(glutamine-N5) methyltransferase activity
A6F57_RS15720	COG2719	SpoVR family
A6F57_RS15725	COG2718	Belongs to the UPF0229 family
A6F57_RS15730	COG2766	serine protein kinase
A6F57_RS15735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6F57_RS15740	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6F57_RS15745	COG4771	TonB-dependent receptor
A6F57_RS15770	COG0450	alkyl hydroperoxide reductase
A6F57_RS15775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6F57_RS15780	COG2885	chlorophyll binding
A6F57_RS15785	COG0584	glycerophosphoryl diester phosphodiesterase
A6F57_RS15790	COG0346	lactoylglutathione lyase activity
A6F57_RS15795	COG1278	Cold shock
A6F57_RS15820	COG1506	peptidase
A6F57_RS15820	COG0823	Involved in the tonB-independent uptake of proteins
A6F57_RS15820	COG4946	Tricorn protease homolog
A6F57_RS15825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F57_RS15830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6F57_RS15835	COG4660	Part of a membrane complex involved in electron transport
A6F57_RS15840	COG4659	FMN binding
A6F57_RS15845	COG4658	electron transport chain
A6F57_RS15850	COG4656	Part of a membrane complex involved in electron transport
A6F57_RS15855	COG2878	Part of a membrane complex involved in electron transport
A6F57_RS15860	COG4657	Part of a membrane complex involved in electron transport
A6F57_RS15875	COG0534	Mate efflux family protein
A6F57_RS15880	COG0556	nucleotide-excision repair
A6F57_RS15905	COG0602	queuosine metabolic process
A6F57_RS15915	COG0367	asparagine synthase
A6F57_RS15940	COG0471	metal ion transport
A6F57_RS15940	COG3273	potassium ion transport
A6F57_RS15955	COG0529	Catalyzes the synthesis of activated sulfate
A6F57_RS15960	COG0175	sulfate reduction
A6F57_RS15965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F57_RS15970	COG3706	GGDEF domain
A6F57_RS15995	COG2304	oxidoreductase activity
A6F57_RS16015	COG0714	Associated with various cellular activities
A6F57_RS16025	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6F57_RS16025	COG1024	Enoyl-CoA hydratase
A6F57_RS16040	COG1025	Belongs to the peptidase M16 family
A6F57_RS16045	COG2062	phosphohistidine phosphatase, SixA
A6F57_RS16055	COG4536	flavin adenine dinucleotide binding
A6F57_RS16060	COG4137	Cytochrome C assembly protein
A6F57_RS16065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6F57_RS16095	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6F57_RS16105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F57_RS16110	COG1132	(ABC) transporter
A6F57_RS16115	COG2873	o-acetylhomoserine
A6F57_RS16130	COG0228	four-way junction DNA binding
A6F57_RS16135	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6F57_RS16140	COG0336	Belongs to the RNA methyltransferase TrmD family
A6F57_RS16145	COG0335	large ribosomal subunit rRNA binding
A6F57_RS16160	COG2860	membrane
A6F57_RS16165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6F57_RS16170	COG0287	Prephenate dehydrogenase
A6F57_RS16170	COG1605	Chorismate mutase
A6F57_RS16175	COG0840	transmembrane signaling receptor activity
A6F57_RS16180	COG1605	Chorismate mutase
A6F57_RS16180	COG0077	Prephenate dehydratase
A6F57_RS16185	COG0745	RESPONSE REGULATOR receiver
A6F57_RS16190	COG0023	Translation Initiation Factor
A6F57_RS16220	COG2205	protein histidine kinase activity
A6F57_RS16230	COG2204	response regulator
A6F57_RS16245	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6F57_RS16255	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6F57_RS16260	COG0632	four-way junction helicase activity
A6F57_RS16265	COG2255	four-way junction helicase activity
A6F57_RS16270	COG0824	Thioesterase
A6F57_RS16275	COG0811	peptide transport
A6F57_RS16290	COG0823	Involved in the tonB-independent uptake of proteins
A6F57_RS16295	COG2885	chlorophyll binding
A6F57_RS16300	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A6F57_RS16320	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6F57_RS16425	COG2205	protein histidine kinase activity
A6F57_RS16425	COG0784	Response regulator, receiver
A6F57_RS16430	COG2271	Major facilitator Superfamily
A6F57_RS16460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6F57_RS16470	COG3038	cytochrome b561
A6F57_RS16475	COG0583	DNA-binding transcription factor activity
A6F57_RS16490	COG0517	IMP dehydrogenase activity
A6F57_RS16495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6F57_RS16505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6F57_RS16515	COG1309	transcriptional regulator
A6F57_RS16520	COG0583	DNA-binding transcription factor activity
A6F57_RS16550	COG3008	intermembrane lipid transfer
A6F57_RS16550	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6F57_RS16555	COG2995	paraquat-inducible protein a
A6F57_RS16565	COG0017	Asparaginyl-tRNA synthetase
A6F57_RS16580	COG0189	ligase activity
A6F57_RS16585	COG0456	acetyltransferase
A6F57_RS16610	COG0156	8-amino-7-oxononanoate synthase activity
A6F57_RS16615	COG1073	alpha beta
A6F57_RS16615	COG2226	methyltransferase
A6F57_RS16630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6F57_RS16635	COG4139	cobalamin transport
A6F57_RS16645	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A6F57_RS16660	COG5265	(ABC) transporter
A6F57_RS16665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6F57_RS16675	COG0745	RESPONSE REGULATOR receiver
A6F57_RS16695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F57_RS16735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6F57_RS16755	COG4181	ATPase activity
A6F57_RS16760	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A6F57_RS16770	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6F57_RS16775	COG0628	permease
A6F57_RS16780	COG2205	protein histidine kinase activity
A6F57_RS16800	COG2350	Protein conserved in bacteria
A6F57_RS16805	COG0159	tryptophan synthase activity
A6F57_RS16815	COG0134	indole-3-glycerol-phosphate synthase activity
A6F57_RS16815	COG0135	phosphoribosylanthranilate isomerase activity
A6F57_RS16820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6F57_RS16830	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6F57_RS16835	COG0613	PHP domain protein
A6F57_RS16840	COG0009	L-threonylcarbamoyladenylate synthase
A6F57_RS16845	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6F57_RS16850	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6F57_RS16865	COG0656	L-ascorbic acid biosynthetic process
A6F57_RS16870	COG0110	maltose O-acetyltransferase activity
A6F57_RS16885	COG2733	membrane
A6F57_RS16890	COG0500	methyltransferase
A6F57_RS16895	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6F57_RS16900	COG0497	DNA recombination
A6F57_RS16905	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6F57_RS16910	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_RS16920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F57_RS16925	COG2610	gluconate transmembrane transporter activity
A6F57_RS16930	COG4771	TonB-dependent receptor
A6F57_RS16940	COG0784	Response regulator, receiver
A6F57_RS16940	COG2205	protein histidine kinase activity
A6F57_RS16945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6F57_RS16955	COG0484	heat shock protein binding
A6F57_RS16960	COG3909	cytochrome
A6F57_RS16965	COG4251	negative regulation of phosphorylation
A6F57_RS16965	COG3706	GGDEF domain
A6F57_RS16965	COG2203	Gaf domain
A6F57_RS16965	COG5001	Diguanylate cyclase
A6F57_RS16980	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6F57_RS16985	COG0505	Belongs to the CarA family
A6F57_RS16990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6F57_RS17020	COG0071	Belongs to the small heat shock protein (HSP20) family
A6F57_RS17030	COG0857	belongs to the CobB CobQ family
A6F57_RS17030	COG0280	phosphate acetyltransferase
A6F57_RS17035	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6F57_RS17040	COG4535	Mg2 and Co2 transporter CorC
A6F57_RS17050	COG1702	phosphate starvation-inducible protein PhoH
A6F57_RS17060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6F57_RS17075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6F57_RS17080	COG1115	amino acid carrier protein
A6F57_RS17105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6F57_RS17110	COG0012	GTP binding
A6F57_RS17125	COG1064	alcohol dehydrogenase
A6F57_RS17135	COG3300	MHYT domain
A6F57_RS17135	COG5001	Diguanylate cyclase
A6F57_RS17140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6F57_RS17150	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6F57_RS17155	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A6F57_RS17160	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6F57_RS17170	COG2890	protein-(glutamine-N5) methyltransferase activity
A6F57_RS17175	COG0784	Response regulator, receiver
A6F57_RS17175	COG3437	response regulator, receiver
A6F57_RS17185	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A6F57_RS17195	COG0583	DNA-binding transcription factor activity
A6F57_RS17215	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6F57_RS17220	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
A6F57_RS17225	COG0515	serine threonine protein kinase
A6F57_RS17225	COG2815	serine threonine protein kinase
A6F57_RS17230	COG2116	formate transmembrane transporter activity
A6F57_RS17245	COG0714	Associated with various cellular activities
A6F57_RS17250	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A6F57_RS17255	COG0033	Phosphoglucomutase
A6F57_RS17260	COG0058	SHG alpha-glucan phosphorylase activity
A6F57_RS17270	COG2988	succinylglutamate desuccinylase activity
A6F57_RS17300	COG1393	Belongs to the ArsC family
A6F57_RS17305	COG2190	(PTS) system
A6F57_RS17305	COG2211	Major facilitator Superfamily
A6F57_RS17330	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A6F57_RS17345	COG3706	GGDEF domain
A6F57_RS17365	COG3447	MASE1 domain protein
A6F57_RS17365	COG5002	protein histidine kinase activity
A6F57_RS17365	COG5001	Diguanylate cyclase
A6F57_RS17375	COG0402	S-adenosylhomocysteine deaminase activity
A6F57_RS17380	COG2351	hydroxyisourate hydrolase activity
A6F57_RS17395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6F57_RS17405	COG1309	transcriptional regulator
A6F57_RS17420	COG2252	PERMEase
A6F57_RS17425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6F57_RS17435	COG5001	Diguanylate cyclase
A6F57_RS17435	COG3300	MHYT domain
A6F57_RS17445	COG2205	protein histidine kinase activity
A6F57_RS17445	COG0784	Response regulator, receiver
A6F57_RS17460	COG2233	PERMEase
A6F57_RS17465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6F57_RS17480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6F57_RS17485	COG0730	response to heat
A6F57_RS17525	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_RS17535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6F57_RS17555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6F57_RS17565	COG1596	polysaccharide export
A6F57_RS17570	COG0489	protein tyrosine kinase activity
A6F57_RS17575	COG4464	protein tyrosine phosphatase activity
A6F57_RS17610	COG0438	transferase activity, transferring glycosyl groups
A6F57_RS17655	COG0438	transferase activity, transferring glycosyl groups
A6F57_RS17680	COG0072	phenylalanine-tRNA ligase activity
A6F57_RS17680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F57_RS17695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6F57_RS17705	COG1472	Belongs to the glycosyl hydrolase 3 family
A6F57_RS17715	COG2096	Adenosyltransferase
A6F57_RS17725	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6F57_RS17735	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6F57_RS17750	COG0708	Exodeoxyribonuclease III
A6F57_RS17785	COG2814	Major facilitator Superfamily
A6F57_RS17800	COG1957	nucleoside hydrolase
A6F57_RS17830	COG4770	biotin carboxylase activity
A6F57_RS17835	COG1024	Enoyl-CoA hydratase
A6F57_RS17840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6F57_RS17845	COG1960	acyl-CoA dehydrogenase activity
A6F57_RS17850	COG0789	Transcriptional regulator
A6F57_RS17855	COG0183	Belongs to the thiolase family
A6F57_RS17870	COG2925	Exonuclease
A6F57_RS17875	COG3437	response regulator, receiver
A6F57_RS17875	COG2205	protein histidine kinase activity
A6F57_RS17875	COG4999	Histidine kinase
A6F57_RS17875	COG3850	Histidine kinase
A6F57_RS17915	COG1643	Atp-dependent helicase
A6F57_RS17935	COG3321	synthase
A6F57_RS17935	COG0604	alcohol dehydrogenase
A6F57_RS17940	COG0328	RNA-DNA hybrid ribonuclease activity
A6F57_RS17975	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A6F57_RS17985	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6F57_RS17990	COG1301	dicarboxylic acid transport
A6F57_RS18000	COG3724	N-succinylarginine dihydrolase activity
A6F57_RS18005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6F57_RS18015	COG0583	DNA-binding transcription factor activity
A6F57_RS18025	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6F57_RS18040	COG0625	glutathione transferase activity
A6F57_RS18060	COG2153	protein acetylation
A6F57_RS18080	COG1530	ribonuclease E activity
A6F57_RS18090	COG0546	phosphoglycolate phosphatase activity
A6F57_RS18095	COG0424	maF-like protein
A6F57_RS18100	COG1399	metal-binding, possibly nucleic acid-binding protein
A6F57_RS18110	COG0416	fatty acid biosynthetic process
A6F57_RS18115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6F57_RS18130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6F57_RS18135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6F57_RS18140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6F57_RS18145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6F57_RS18155	COG0470	DNA polymerase III
A6F57_RS18160	COG0084	hydrolase, TatD family'
A6F57_RS18170	COG0702	epimerase
A6F57_RS18195	COG1714	RDD family
A6F57_RS18215	COG1942	4-Oxalocrotonate Tautomerase
A6F57_RS18235	COG0574	Belongs to the PEP-utilizing enzyme family
A6F57_RS18235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6F57_RS18255	COG0679	Auxin Efflux Carrier
A6F57_RS18260	COG1609	Transcriptional regulator
A6F57_RS18275	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_RS18285	COG3265	gluconokinase activity
A6F57_RS18330	COG1695	Transcriptional regulator
A6F57_RS18370	COG2801	Transposase and inactivated derivatives
A6F57_RS18385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6F57_RS18390	COG3123	guanosine phosphorylase activity
A6F57_RS18395	COG0277	FAD linked oxidase domain protein
A6F57_RS18395	COG0247	lactate metabolic process
A6F57_RS18410	COG2850	peptidyl-arginine hydroxylation
A6F57_RS18420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6F57_RS18425	COG2915	High frequency lysogenization protein hflD homolog
A6F57_RS18430	COG0482	sulfurtransferase activity
A6F57_RS18435	COG1187	pseudouridine synthase activity
A6F57_RS18445	COG1278	Cold shock
A6F57_RS18450	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6F57_RS18455	COG0542	response to heat
A6F57_RS18460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6F57_RS18465	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A6F57_RS18475	COG0492	ferredoxin-NADP+ reductase activity
A6F57_RS18490	COG3091	SprT-like family
A6F57_RS18495	COG0616	signal peptide processing
A6F57_RS18510	COG0778	Nitroreductase
A6F57_RS18520	COG0252	asparaginase activity
A6F57_RS18530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6F57_RS18535	COG0321	lipoyl(octanoyl) transferase activity
A6F57_RS18540	COG2921	Belongs to the UPF0250 family
A6F57_RS18545	COG1686	Belongs to the peptidase S11 family
A6F57_RS18550	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6F57_RS18555	COG0772	Belongs to the SEDS family
A6F57_RS18565	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6F57_RS18570	COG0799	negative regulation of ribosome biogenesis
A6F57_RS18575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6F57_RS18580	COG1466	dna polymerase III delta subunit
A6F57_RS18590	COG0495	leucyl-tRNA aminoacylation
A6F57_RS18595	COG1067	ATP-dependent peptidase activity
A6F57_RS18605	COG1534	Rna-binding protein
A6F57_RS18610	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6F57_RS18620	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6F57_RS18625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6F57_RS18630	COG0149	triose-phosphate isomerase activity
A6F57_RS18635	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6F57_RS18675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F57_RS18680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6F57_RS18685	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6F57_RS18700	COG1185	polyribonucleotide nucleotidyltransferase activity
A6F57_RS18710	COG1119	ATPase activity
A6F57_RS18715	COG0454	-acetyltransferase
A6F57_RS18725	COG4628	conserved protein (DUF2132)
A6F57_RS18770	COG1238	metal cluster binding
A6F57_RS18780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6F57_RS18790	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6F57_RS18795	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6F57_RS18800	COG0436	Aminotransferase
A6F57_RS18825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F57_RS18830	COG1765	OsmC-like protein
A6F57_RS18835	COG2996	Protein conserved in bacteria
A6F57_RS18840	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A6F57_RS18850	COG1984	allophanate hydrolase subunit 2
A6F57_RS18860	COG1609	Transcriptional regulator
A6F57_RS18865	COG3265	gluconokinase activity
A6F57_RS18885	COG0716	FMN binding
A6F57_RS18895	COG0596	Alpha beta hydrolase
A6F57_RS18945	COG1917	Cupin 2, conserved barrel domain protein
A6F57_RS18945	COG2207	Transcriptional regulator
A6F57_RS18950	COG1960	acyl-CoA dehydrogenase activity
A6F57_RS18960	COG1028	Short-chain dehydrogenase reductase Sdr
A6F57_RS18965	COG1671	Belongs to the UPF0178 family
A6F57_RS18970	COG1448	Aminotransferase
A6F57_RS19005	COG1024	Enoyl-CoA hydratase
A6F57_RS19010	COG0405	Gamma-glutamyltransferase
A6F57_RS19020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6F57_RS19040	COG0534	Mate efflux family protein
A6F57_RS19045	COG0303	'Molybdopterin
A6F57_RS19055	COG1215	transferase activity, transferring glycosyl groups
A6F57_RS19060	COG3769	mannosylglycerate metabolic process
A6F57_RS19065	COG0572	uridine kinase
A6F57_RS19100	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6F57_RS19135	COG1393	Belongs to the ArsC family
A6F57_RS19145	COG4783	chaperone-mediated protein folding
A6F57_RS19155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6F57_RS19165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6F57_RS19170	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A6F57_RS19205	COG1131	(ABC) transporter
A6F57_RS19360	COG5002	protein histidine kinase activity
A6F57_RS19365	COG0633	Ferredoxin
A6F57_RS19370	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6F57_RS19375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6F57_RS19390	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6F57_RS19395	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6F57_RS19400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6F57_RS19405	COG0539	negative regulation of cytoplasmic translation
A6F57_RS19410	COG0776	regulation of translation
A6F57_RS19420	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A6F57_RS19425	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6F57_RS19430	COG0284	orotidine-5'-phosphate decarboxylase activity
A6F57_RS19435	COG0686	Belongs to the AlaDH PNT family
A6F57_RS19445	COG1674	ftsk spoiiie
A6F57_RS19445	COG0531	amino acid
A6F57_RS19450	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A6F57_RS19455	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6F57_RS19470	COG0561	phosphatase activity
A6F57_RS19475	COG2920	part of a sulfur-relay system
A6F57_RS19485	COG2923	Belongs to the DsrF TusC family
A6F57_RS19495	COG0670	Belongs to the BI1 family
A6F57_RS19520	COG0745	RESPONSE REGULATOR receiver
A6F57_RS19525	COG0642	Histidine kinase
A6F57_RS19555	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6F57_RS19575	COG2197	response regulator
A6F57_RS19580	COG0322	excinuclease ABC activity
A6F57_RS19655	COG5532	Uncharacterized conserved protein (DUF2303)
A6F57_RS19670	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6F57_RS19875	COG3148	PFAM DTW domain containing protein
A6F57_RS19880	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A6F57_RS19885	COG2897	thiosulfate sulfurtransferase activity
A6F57_RS19895	COG1280	lysine exporter protein (LysE YggA)
A6F57_RS19915	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6F57_RS19920	COG0037	tRNA processing
A6F57_RS19930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6F57_RS19955	COG2010	Cytochrome c
A6F57_RS19970	COG3278	Belongs to the heme-copper respiratory oxidase family
A6F57_RS19980	COG2193	ferroxidase activity
A6F57_RS19995	COG0069	glutamate synthase activity
A6F57_RS20005	COG0589	response to stress
A6F57_RS20010	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6F57_RS20065	COG3046	protein related to deoxyribodipyrimidine photolyase
A6F57_RS20070	COG0415	Belongs to the DNA photolyase family
A6F57_RS20075	COG0415	Belongs to the DNA photolyase family
A6F57_RS20085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6F57_RS20090	COG3130	regulation of translation
A6F57_RS20100	COG0488	(ABC) transporter
A6F57_RS20115	COG0167	dihydroorotate dehydrogenase activity
A6F57_RS20120	COG2902	Dehydrogenase
A6F57_RS20150	COG0308	aminopeptidase N
A6F57_RS20155	COG1757	Na H antiporter
A6F57_RS20160	COG0733	neurotransmitter:sodium symporter activity
A6F57_RS20165	COG0793	Belongs to the peptidase S41A family
A6F57_RS20180	COG1956	GAF domain-containing protein
A6F57_RS20190	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6F57_RS20200	COG1946	Acyl-CoA thioesterase
A6F57_RS20205	COG0515	serine threonine protein kinase
A6F57_RS20210	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6F57_RS20215	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F57_RS20220	COG0022	dehydrogenase e1 component
A6F57_RS20225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6F57_RS20230	COG1404	Belongs to the peptidase S8 family
A6F57_RS20245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6F57_RS20250	COG0494	nUDIX hydrolase
A6F57_RS20255	COG1760	l-serine dehydratase
A6F57_RS20275	COG0583	DNA-binding transcription factor activity
A6F57_RS20280	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A6F57_RS20285	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit