locus-tag	class	description
ALE3EI_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ALE3EI_RS00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ALE3EI_RS00035	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ALE3EI_RS00045	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ALE3EI_RS00050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ALE3EI_RS00060	COG0456	acetyltransferase
ALE3EI_RS00070	COG0336	Belongs to the RNA methyltransferase TrmD family
ALE3EI_RS00075	COG0335	large ribosomal subunit rRNA binding
ALE3EI_RS00085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ALE3EI_RS00125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ALE3EI_RS00130	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ALE3EI_RS00135	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ALE3EI_RS00140	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ALE3EI_RS00160	COG0492	ferredoxin-NADP+ reductase activity
ALE3EI_RS00185	COG1333	cytochrome c biogenesis protein
ALE3EI_RS00185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ALE3EI_RS00190	COG0305	Participates in initiation and elongation during chromosome replication
ALE3EI_RS00195	COG0825	malonyl-CoA metabolic process
ALE3EI_RS00210	COG0343	queuine tRNA-ribosyltransferase activity
ALE3EI_RS00220	COG3958	Transketolase
ALE3EI_RS00235	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ALE3EI_RS00240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ALE3EI_RS00260	COG1233	COG1233 Phytoene dehydrogenase and related
ALE3EI_RS00280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALE3EI_RS00290	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ALE3EI_RS00295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ALE3EI_RS00295	COG2755	lipolytic protein G-D-S-L family
ALE3EI_RS00300	COG0714	Associated with various cellular activities
ALE3EI_RS00305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ALE3EI_RS00335	COG0516	GMP reductase activity
ALE3EI_RS00335	COG0517	IMP dehydrogenase activity
ALE3EI_RS00350	COG1730	sister chromatid segregation
ALE3EI_RS00360	COG0737	Belongs to the 5'-nucleotidase family
ALE3EI_RS00370	COG1280	lysine exporter protein (LysE YggA)
ALE3EI_RS00375	COG0167	dihydroorotate dehydrogenase activity
ALE3EI_RS00380	COG2195	Cleaves the N-terminal amino acid of tripeptides
ALE3EI_RS00385	COG1862	Preprotein translocase
ALE3EI_RS00395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ALE3EI_RS00400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ALE3EI_RS00405	COG1132	(ABC) transporter
ALE3EI_RS00420	COG0659	secondary active sulfate transmembrane transporter activity
ALE3EI_RS00455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALE3EI_RS00470	COG2318	DinB family
ALE3EI_RS00475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ALE3EI_RS00480	COG0514	ATP-dependent DNA helicase (RecQ)
ALE3EI_RS00485	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ALE3EI_RS00485	COG0517	IMP dehydrogenase activity
ALE3EI_RS00490	COG0805	protein transport
ALE3EI_RS00500	COG1137	ATPase activity
ALE3EI_RS00505	COG1183	phosphatidylcholine synthase activity
ALE3EI_RS00520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ALE3EI_RS00545	COG0438	transferase activity, transferring glycosyl groups
ALE3EI_RS00565	COG1083	cytidylyl-transferase
ALE3EI_RS00570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ALE3EI_RS00575	COG2089	acid synthase
ALE3EI_RS00580	COG0297	glycogen (starch) synthase activity
ALE3EI_RS00605	COG0463	Glycosyl transferase, family 2
ALE3EI_RS00615	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ALE3EI_RS00620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ALE3EI_RS00625	COG0438	transferase activity, transferring glycosyl groups
ALE3EI_RS00635	COG1215	transferase activity, transferring glycosyl groups
ALE3EI_RS00675	COG2852	Protein conserved in bacteria
ALE3EI_RS00685	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ALE3EI_RS00705	COG0488	(ABC) transporter
ALE3EI_RS00715	COG0577	efflux transmembrane transporter activity
ALE3EI_RS00715	COG1136	(ABC) transporter
ALE3EI_RS00740	COG0653	protein targeting
ALE3EI_RS00795	COG1595	DNA-templated transcription, initiation
ALE3EI_RS00805	COG1764	response to oxidative stress
ALE3EI_RS00810	COG1703	isobutyryl-CoA mutase activity
ALE3EI_RS00815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ALE3EI_RS00820	COG0463	Glycosyl transferase, family 2
ALE3EI_RS00835	COG0671	phosphoesterase, PA-phosphatase related
ALE3EI_RS00845	COG0534	Mate efflux family protein
ALE3EI_RS00865	COG2326	polyphosphate kinase activity
ALE3EI_RS00870	COG2204	response regulator
ALE3EI_RS00880	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ALE3EI_RS00880	COG3264	Mechanosensitive ion channel
ALE3EI_RS00885	COG1668	transmembrane transport
ALE3EI_RS00890	COG4152	abc transporter atp-binding protein
ALE3EI_RS00895	COG0484	heat shock protein binding
ALE3EI_RS00900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ALE3EI_RS00915	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ALE3EI_RS00915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ALE3EI_RS00925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ALE3EI_RS00945	COG4585	Histidine kinase
ALE3EI_RS00950	COG2197	response regulator
ALE3EI_RS00970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ALE3EI_RS00985	COG1522	sequence-specific DNA binding
ALE3EI_RS00995	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ALE3EI_RS00995	COG1703	isobutyryl-CoA mutase activity
ALE3EI_RS00995	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ALE3EI_RS01020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ALE3EI_RS01025	COG0284	orotidine-5'-phosphate decarboxylase activity
ALE3EI_RS01030	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ALE3EI_RS01035	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ALE3EI_RS01045	COG1462	curli production assembly transport component CsgG
ALE3EI_RS01095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ALE3EI_RS01125	COG2264	protein methyltransferase activity
ALE3EI_RS01130	COG0149	triose-phosphate isomerase activity
ALE3EI_RS01135	COG0601	transmembrane transport
ALE3EI_RS01150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ALE3EI_RS01155	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ALE3EI_RS01165	COG1132	(ABC) transporter
ALE3EI_RS01170	COG0101	tRNA pseudouridine synthase activity
ALE3EI_RS01210	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ALE3EI_RS01220	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ALE3EI_RS01220	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ALE3EI_RS01225	COG0799	negative regulation of ribosome biogenesis
ALE3EI_RS01230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ALE3EI_RS01245	COG0688	phosphatidylethanolamine metabolic process
ALE3EI_RS01260	COG0525	valine-tRNA ligase activity
ALE3EI_RS01270	COG0750	zinc metalloprotease
ALE3EI_RS01275	COG0436	Aminotransferase
ALE3EI_RS01280	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ALE3EI_RS01285	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ALE3EI_RS01310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ALE3EI_RS01315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ALE3EI_RS01325	COG1663	tetraacyldisaccharide 4'-kinase activity
ALE3EI_RS01330	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ALE3EI_RS01345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ALE3EI_RS01370	COG3844	kynureninase activity
ALE3EI_RS01375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ALE3EI_RS01390	COG1028	Short-chain dehydrogenase reductase Sdr
ALE3EI_RS01405	COG0671	phosphoesterase, PA-phosphatase related
ALE3EI_RS01410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ALE3EI_RS01435	COG3340	Belongs to the peptidase S51 family
ALE3EI_RS01440	COG1876	peptidase activity
ALE3EI_RS01445	COG0501	Belongs to the peptidase M48B family
ALE3EI_RS01450	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ALE3EI_RS01465	COG2226	methyltransferase
ALE3EI_RS01470	COG1477	protein flavinylation
ALE3EI_RS01490	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ALE3EI_RS01500	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ALE3EI_RS01505	COG1805	sodium ion transport
ALE3EI_RS01525	COG2967	ApaG domain
ALE3EI_RS01540	COG3292	Two component regulator propeller
ALE3EI_RS01540	COG2205	protein histidine kinase activity
ALE3EI_RS01540	COG0745	RESPONSE REGULATOR receiver
ALE3EI_RS01550	COG1012	belongs to the aldehyde dehydrogenase family
ALE3EI_RS01560	COG0357	Ribosomal RNA small subunit methyltransferase G
ALE3EI_RS01565	COG3239	Fatty acid desaturase
ALE3EI_RS01590	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ALE3EI_RS01600	COG0569	domain protein
ALE3EI_RS01605	COG2226	methyltransferase
ALE3EI_RS01625	COG0191	fructose-bisphosphate aldolase activity
ALE3EI_RS01630	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ALE3EI_RS01640	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ALE3EI_RS01645	COG1185	polyribonucleotide nucleotidyltransferase activity
ALE3EI_RS01670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ALE3EI_RS01680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ALE3EI_RS01730	COG1610	YqeY-like protein
ALE3EI_RS01735	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ALE3EI_RS01750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ALE3EI_RS01755	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ALE3EI_RS01760	COG0772	Belongs to the SEDS family
ALE3EI_RS01765	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ALE3EI_RS01770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ALE3EI_RS01775	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ALE3EI_RS01780	COG0768	penicillin binding
ALE3EI_RS01790	COG0275	rRNA processing
ALE3EI_RS01795	COG2001	Belongs to the MraZ family
ALE3EI_RS01805	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ALE3EI_RS01820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ALE3EI_RS01825	COG2197	response regulator
ALE3EI_RS01830	COG0358	DNA primase activity
ALE3EI_RS01880	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ALE3EI_RS01890	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ALE3EI_RS01920	COG1490	D-aminoacyl-tRNA deacylase activity
ALE3EI_RS01925	COG1162	GTPase activity
ALE3EI_RS01930	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ALE3EI_RS01960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ALE3EI_RS01965	COG1959	2 iron, 2 sulfur cluster binding
ALE3EI_RS01970	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ALE3EI_RS01980	COG1410	methionine synthase
ALE3EI_RS01980	COG0646	methionine synthase
ALE3EI_RS01985	COG1765	OsmC-like protein
ALE3EI_RS01990	COG0460	homoserine dehydrogenase
ALE3EI_RS01990	COG0527	aspartate kinase activity
ALE3EI_RS01995	COG0626	cystathionine gamma-synthase activity
ALE3EI_RS02005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ALE3EI_RS02015	COG2197	response regulator
ALE3EI_RS02065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ALE3EI_RS02100	COG1160	GTP binding
ALE3EI_RS02105	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ALE3EI_RS02145	COG0730	response to heat
ALE3EI_RS02165	COG0745	RESPONSE REGULATOR receiver
ALE3EI_RS02170	COG5002	protein histidine kinase activity
ALE3EI_RS02195	COG4585	Histidine kinase
ALE3EI_RS02265	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ALE3EI_RS02270	COG1401	restriction endodeoxyribonuclease activity
ALE3EI_RS02315	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ALE3EI_RS02395	COG0488	(ABC) transporter
ALE3EI_RS02405	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ALE3EI_RS02405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ALE3EI_RS02425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ALE3EI_RS02450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALE3EI_RS02475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ALE3EI_RS02480	COG0459	protein refolding
ALE3EI_RS02495	COG2217	Heavy metal translocating P-type atpase
ALE3EI_RS02500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ALE3EI_RS02545	COG0138	bifunctional purine biosynthesis protein purh
ALE3EI_RS02550	COG1077	Cell shape determining protein MreB Mrl
ALE3EI_RS02565	COG0768	penicillin binding
ALE3EI_RS02570	COG0772	Belongs to the SEDS family
ALE3EI_RS02580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ALE3EI_RS02590	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ALE3EI_RS02600	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALE3EI_RS02605	COG0791	NLP P60 protein
ALE3EI_RS02610	COG0658	competence protein
ALE3EI_RS02610	COG2333	competence protein COMEC
ALE3EI_RS02620	COG3104	oligopeptide transport
ALE3EI_RS02625	COG3104	oligopeptide transport
ALE3EI_RS02630	COG1506	peptidase
ALE3EI_RS02630	COG0823	Involved in the tonB-independent uptake of proteins
ALE3EI_RS02650	COG1253	flavin adenine dinucleotide binding
ALE3EI_RS02675	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ALE3EI_RS02700	COG3483	tryptophan 2,3-dioxygenase activity
ALE3EI_RS02720	COG1054	Belongs to the UPF0176 family
ALE3EI_RS02730	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ALE3EI_RS02740	COG0306	phosphate transporter
ALE3EI_RS02775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ALE3EI_RS02790	COG1215	transferase activity, transferring glycosyl groups
ALE3EI_RS02800	COG2234	aminopeptidase activity
ALE3EI_RS02820	COG3153	acetyltransferase
ALE3EI_RS02820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ALE3EI_RS02830	COG0010	Belongs to the arginase family
ALE3EI_RS02835	COG1166	arginine decarboxylase activity
ALE3EI_RS02840	COG1187	pseudouridine synthase activity
ALE3EI_RS02900	COG2081	HI0933 family
ALE3EI_RS02910	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ALE3EI_RS02915	COG0463	Glycosyl transferase, family 2
ALE3EI_RS02935	COG2824	Alkylphosphonate utilization operon protein PhnA
ALE3EI_RS02985	COG2315	Protein conserved in bacteria
ALE3EI_RS03005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ALE3EI_RS03010	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ALE3EI_RS03090	COG1704	LemA family
ALE3EI_RS03115	COG0740	serine-type endopeptidase activity
ALE3EI_RS03155	COG0228	four-way junction DNA binding
ALE3EI_RS03160	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ALE3EI_RS03165	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ALE3EI_RS03170	COG0531	amino acid
ALE3EI_RS03195	COG0492	ferredoxin-NADP+ reductase activity
ALE3EI_RS03205	COG0489	protein tyrosine kinase activity
ALE3EI_RS03210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ALE3EI_RS03220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ALE3EI_RS03225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ALE3EI_RS03230	COG5002	protein histidine kinase activity
ALE3EI_RS03235	COG0745	RESPONSE REGULATOR receiver
ALE3EI_RS03255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ALE3EI_RS03270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ALE3EI_RS03275	COG1216	Glycosyl transferase, family 2
ALE3EI_RS03290	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ALE3EI_RS03295	COG2363	Small membrane protein
ALE3EI_RS03305	COG2738	Putative neutral zinc metallopeptidase
ALE3EI_RS03310	COG0495	leucyl-tRNA aminoacylation
ALE3EI_RS03315	COG2177	Part of the ABC transporter FtsEX involved in
ALE3EI_RS03330	COG1968	undecaprenyl-diphosphatase activity
ALE3EI_RS03335	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ALE3EI_RS03345	COG0519	Catalyzes the synthesis of GMP from XMP
ALE3EI_RS03355	COG2957	Belongs to the agmatine deiminase family
ALE3EI_RS03360	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ALE3EI_RS03370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ALE3EI_RS03375	COG3852	Histidine kinase
ALE3EI_RS03390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALE3EI_RS03405	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ALE3EI_RS03420	COG3201	nicotinamide mononucleotide transporter
ALE3EI_RS03430	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ALE3EI_RS03440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ALE3EI_RS03450	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ALE3EI_RS03455	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ALE3EI_RS03480	COG0629	single-stranded DNA binding
ALE3EI_RS03485	COG1194	a g-specific adenine glycosylase
ALE3EI_RS03490	COG0776	regulation of translation
ALE3EI_RS03495	COG1530	ribonuclease E activity
ALE3EI_RS03515	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ALE3EI_RS03520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ALE3EI_RS03530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ALE3EI_RS03535	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ALE3EI_RS03540	COG0156	8-amino-7-oxononanoate synthase activity
ALE3EI_RS03550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ALE3EI_RS03555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ALE3EI_RS03565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ALE3EI_RS03575	COG0297	glycogen (starch) synthase activity
ALE3EI_RS03580	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ALE3EI_RS03585	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ALE3EI_RS03630	COG2197	response regulator
ALE3EI_RS03635	COG4585	Histidine kinase
ALE3EI_RS03645	COG4566	intracellular signal transduction
ALE3EI_RS03650	COG2197	response regulator
ALE3EI_RS03660	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ALE3EI_RS03670	COG1960	acyl-CoA dehydrogenase activity
ALE3EI_RS03675	COG0667	Aldo Keto reductase
ALE3EI_RS03680	COG2885	chlorophyll binding
ALE3EI_RS03685	COG0708	Exodeoxyribonuclease III
ALE3EI_RS03715	COG0423	glycine-tRNA ligase activity
ALE3EI_RS03725	COG1040	competence protein
ALE3EI_RS03735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ALE3EI_RS03745	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ALE3EI_RS03750	COG0436	Aminotransferase
ALE3EI_RS03755	COG2198	Histidine kinase
ALE3EI_RS03755	COG0784	Response regulator, receiver
ALE3EI_RS03755	COG5002	protein histidine kinase activity
ALE3EI_RS03765	COG1053	succinate dehydrogenase
ALE3EI_RS03780	COG0006	proline dipeptidase activity
ALE3EI_RS03785	COG1114	Component of the transport system for branched-chain amino acids
ALE3EI_RS03805	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ALE3EI_RS03835	COG1858	cytochrome C peroxidase
ALE3EI_RS03840	COG0316	Belongs to the HesB IscA family
ALE3EI_RS03845	COG0719	Fe-S assembly protein
ALE3EI_RS03855	COG0396	ATPase activity
ALE3EI_RS03860	COG0719	Fe-S assembly protein
ALE3EI_RS03865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ALE3EI_RS03875	COG2166	iron-sulfur cluster assembly
ALE3EI_RS03880	COG2151	metal-sulfur cluster biosynthetic enzyme
ALE3EI_RS03900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ALE3EI_RS03945	COG4251	negative regulation of phosphorylation
ALE3EI_RS03960	COG4771	TonB-dependent receptor
ALE3EI_RS03970	COG3483	tryptophan 2,3-dioxygenase activity
ALE3EI_RS03980	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ALE3EI_RS03985	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ALE3EI_RS03990	COG1752	Esterase of the alpha-beta hydrolase superfamily
ALE3EI_RS03995	COG0322	excinuclease ABC activity
ALE3EI_RS04000	COG0189	ligase activity
ALE3EI_RS04010	COG0189	ligase activity
ALE3EI_RS04020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ALE3EI_RS04040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ALE3EI_RS04055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ALE3EI_RS04080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ALE3EI_RS04085	COG3590	peptidase
ALE3EI_RS04110	COG0750	zinc metalloprotease
ALE3EI_RS04115	COG1999	signal sequence binding
ALE3EI_RS04140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ALE3EI_RS04145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ALE3EI_RS04150	COG1121	(ABC) transporter
ALE3EI_RS04155	COG0803	Belongs to the bacterial solute-binding protein 9 family
ALE3EI_RS04165	COG1321	iron dependent repressor
ALE3EI_RS04165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ALE3EI_RS04190	COG0535	radical SAM domain protein
ALE3EI_RS04195	COG1024	Enoyl-CoA hydratase
ALE3EI_RS04200	COG5000	phosphorelay sensor kinase activity
ALE3EI_RS04205	COG1981	membrane
ALE3EI_RS04220	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ALE3EI_RS04230	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ALE3EI_RS04235	COG0181	hydroxymethylbilane synthase activity
ALE3EI_RS04245	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ALE3EI_RS04260	COG0408	coproporphyrinogen oxidase activity
ALE3EI_RS04265	COG0113	porphobilinogen synthase activity
ALE3EI_RS04275	COG1253	flavin adenine dinucleotide binding
ALE3EI_RS04290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ALE3EI_RS04315	COG4172	Belongs to the ABC transporter superfamily
ALE3EI_RS04325	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ALE3EI_RS04330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ALE3EI_RS04340	COG1774	PSP1 C-terminal conserved region
ALE3EI_RS04345	COG1054	Belongs to the UPF0176 family
ALE3EI_RS04350	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ALE3EI_RS04375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ALE3EI_RS04375	COG0758	DNA mediated transformation
ALE3EI_RS04410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ALE3EI_RS04420	COG0756	dUTP diphosphatase activity
ALE3EI_RS04435	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ALE3EI_RS04440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ALE3EI_RS04445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ALE3EI_RS04450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ALE3EI_RS04455	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ALE3EI_RS04460	COG0356	it plays a direct role in the translocation of protons across the membrane
ALE3EI_RS04510	COG0151	Belongs to the GarS family
ALE3EI_RS04515	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ALE3EI_RS04520	COG1215	transferase activity, transferring glycosyl groups
ALE3EI_RS04530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ALE3EI_RS04535	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ALE3EI_RS04540	COG0438	transferase activity, transferring glycosyl groups
ALE3EI_RS04575	COG1091	dTDP-4-dehydrorhamnose reductase activity
ALE3EI_RS04580	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ALE3EI_RS04585	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ALE3EI_RS04605	COG4942	peptidase
ALE3EI_RS04610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ALE3EI_RS04620	COG3584	3D domain protein
ALE3EI_RS04620	COG1388	LysM domain
ALE3EI_RS04625	COG0126	phosphoglycerate kinase activity
ALE3EI_RS04640	COG0445	tRNA wobble uridine modification
ALE3EI_RS04645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ALE3EI_RS04655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ALE3EI_RS04665	COG0330	HflC and HflK could
ALE3EI_RS04685	COG2194	sulfuric ester hydrolase activity
ALE3EI_RS04695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ALE3EI_RS04700	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ALE3EI_RS04715	COG0557	exoribonuclease II activity
ALE3EI_RS04725	COG0698	ribose 5-phosphate isomerase
ALE3EI_RS04735	COG2153	protein acetylation
ALE3EI_RS04750	COG0793	Belongs to the peptidase S41A family
ALE3EI_RS04755	COG0594	ribonuclease P activity
ALE3EI_RS04770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ALE3EI_RS04785	COG0481	GTPase activity
ALE3EI_RS04800	COG4591	ABC-type transport system involved in lipoprotein release permease component
ALE3EI_RS04805	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ALE3EI_RS04810	COG0346	lactoylglutathione lyase activity
ALE3EI_RS04820	COG0307	riboflavin synthase, alpha
ALE3EI_RS04825	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ALE3EI_RS04835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ALE3EI_RS04840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ALE3EI_RS04845	COG0511	ligase activity, forming carbon-carbon bonds
ALE3EI_RS04850	COG0439	Biotin carboxylase
ALE3EI_RS04860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ALE3EI_RS04875	COG3842	ATPase activity
ALE3EI_RS04880	COG1505	serine-type exopeptidase activity
ALE3EI_RS04900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ALE3EI_RS04905	COG1970	mechanosensitive ion channel activity
ALE3EI_RS04910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ALE3EI_RS04915	COG1435	thymidine kinase activity
ALE3EI_RS04925	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ALE3EI_RS04930	COG1573	uracil-dna glycosylase
ALE3EI_RS04940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ALE3EI_RS04940	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ALE3EI_RS04945	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALE3EI_RS04950	COG0720	synthase
ALE3EI_RS04985	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ALE3EI_RS04990	COG2885	chlorophyll binding
ALE3EI_RS05045	COG0328	RNA-DNA hybrid ribonuclease activity
ALE3EI_RS05045	COG3341	Caulimovirus viroplasmin
ALE3EI_RS05050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ALE3EI_RS05055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ALE3EI_RS05060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ALE3EI_RS05065	COG0571	ribonuclease III activity
ALE3EI_RS05075	COG0469	pyruvate kinase activity
ALE3EI_RS05085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ALE3EI_RS05090	COG2954	triphosphatase activity
ALE3EI_RS05105	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ALE3EI_RS05110	COG3250	beta-galactosidase activity
ALE3EI_RS05115	COG4953	penicillin-binding protein 1C
ALE3EI_RS05125	COG2329	Antibiotic biosynthesis monooxygenase
ALE3EI_RS05130	COG1446	asparaginase
ALE3EI_RS05145	COG1012	belongs to the aldehyde dehydrogenase family
ALE3EI_RS05155	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ALE3EI_RS05165	COG4260	virion core protein, lumpy skin disease virus
ALE3EI_RS05180	COG4221	oxidoreductase activity
ALE3EI_RS05195	COG0714	Associated with various cellular activities
ALE3EI_RS05210	COG2304	oxidoreductase activity
ALE3EI_RS05215	COG2304	oxidoreductase activity
ALE3EI_RS05245	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ALE3EI_RS05255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ALE3EI_RS05265	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ALE3EI_RS05270	COG0194	GDP metabolic process
ALE3EI_RS05275	COG1561	YicC-like family, N-terminal region
ALE3EI_RS05310	COG0626	cystathionine gamma-synthase activity
ALE3EI_RS05315	COG3275	phosphorelay sensor kinase activity
ALE3EI_RS05320	COG4566	intracellular signal transduction
ALE3EI_RS05345	COG1381	Involved in DNA repair and RecF pathway recombination
ALE3EI_RS05350	COG4771	TonB-dependent receptor
ALE3EI_RS05355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ALE3EI_RS05385	COG5507	3-demethylubiquinone-9 3-methyltransferase
ALE3EI_RS05395	COG1476	TRANSCRIPTIONal
ALE3EI_RS05405	COG0629	single-stranded DNA binding
ALE3EI_RS05410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALE3EI_RS05410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALE3EI_RS05420	COG1619	proteins homologs of microcin C7 resistance protein MccF
ALE3EI_RS05425	COG0792	nuclease activity
ALE3EI_RS05430	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ALE3EI_RS05440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ALE3EI_RS05455	COG1201	RNA secondary structure unwinding
ALE3EI_RS05460	COG1793	dna ligase
ALE3EI_RS05475	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ALE3EI_RS05485	COG0527	aspartate kinase activity
ALE3EI_RS05495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ALE3EI_RS05505	COG2207	Transcriptional regulator
ALE3EI_RS05520	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ALE3EI_RS05560	COG0784	Response regulator, receiver
ALE3EI_RS05560	COG4191	Histidine kinase
ALE3EI_RS05590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ALE3EI_RS05615	COG0346	lactoylglutathione lyase activity
ALE3EI_RS05620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ALE3EI_RS05630	COG2239	Acts as a magnesium transporter
ALE3EI_RS05635	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ALE3EI_RS05655	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ALE3EI_RS05665	COG0196	riboflavin kinase activity
ALE3EI_RS05670	COG0193	aminoacyl-tRNA hydrolase activity
ALE3EI_RS05675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ALE3EI_RS05680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ALE3EI_RS05700	COG0793	Belongs to the peptidase S41A family
ALE3EI_RS05710	COG2095	MarC family integral membrane protein
ALE3EI_RS05770	COG0659	secondary active sulfate transmembrane transporter activity
ALE3EI_RS05785	COG4771	TonB-dependent receptor
ALE3EI_RS05795	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ALE3EI_RS05800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ALE3EI_RS05810	COG1278	Cold shock
ALE3EI_RS05825	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ALE3EI_RS05830	COG4771	TonB-dependent receptor
ALE3EI_RS05855	COG1309	transcriptional regulator
ALE3EI_RS05895	COG0084	hydrolase, TatD family'
ALE3EI_RS05900	COG0252	asparaginase activity
ALE3EI_RS05910	COG0811	peptide transport
ALE3EI_RS05940	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ALE3EI_RS05945	COG0017	Asparaginyl-tRNA synthetase
ALE3EI_RS05960	COG0233	cytoplasmic translational termination
ALE3EI_RS05965	COG0528	UMP kinase activity
ALE3EI_RS05970	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ALE3EI_RS05975	COG0052	Belongs to the universal ribosomal protein uS2 family
ALE3EI_RS05980	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ALE3EI_RS05985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ALE3EI_RS06000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ALE3EI_RS06000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ALE3EI_RS06015	COG3920	Histidine kinase
ALE3EI_RS06020	COG2010	Cytochrome c
ALE3EI_RS06020	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ALE3EI_RS06035	COG4242	Belongs to the peptidase S51 family
ALE3EI_RS06040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ALE3EI_RS06040	COG0189	ligase activity
ALE3EI_RS06050	COG3279	Response regulator of the LytR AlgR family
ALE3EI_RS06055	COG3920	Histidine kinase
ALE3EI_RS06065	COG1446	asparaginase
ALE3EI_RS06070	COG3537	Alpha-1,2-mannosidase
ALE3EI_RS06075	COG1408	metallophosphoesterase
ALE3EI_RS06080	COG3118	belongs to the thioredoxin family
ALE3EI_RS06125	COG1028	Short-chain dehydrogenase reductase Sdr
ALE3EI_RS06135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ALE3EI_RS06160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ALE3EI_RS06165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ALE3EI_RS06175	COG0726	polysaccharide deacetylase
ALE3EI_RS06185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ALE3EI_RS06190	COG0463	Glycosyl transferase, family 2
ALE3EI_RS06210	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ALE3EI_RS06220	COG0589	response to stress
ALE3EI_RS06225	COG0779	Required for maturation of 30S ribosomal subunits
ALE3EI_RS06230	COG0195	Participates in both transcription termination and antitermination
ALE3EI_RS06235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ALE3EI_RS06250	COG0437	4 iron, 4 sulfur cluster binding
ALE3EI_RS06255	COG0052	Belongs to the universal ribosomal protein uS2 family
ALE3EI_RS06275	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ALE3EI_RS06280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ALE3EI_RS06285	COG0534	Mate efflux family protein
ALE3EI_RS06295	COG2255	four-way junction helicase activity
ALE3EI_RS06305	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ALE3EI_RS06310	COG0280	phosphate acetyltransferase
ALE3EI_RS06310	COG0281	malic enzyme
ALE3EI_RS06315	COG0632	four-way junction helicase activity
ALE3EI_RS06325	COG0509	glycine decarboxylation via glycine cleavage system
ALE3EI_RS06350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ALE3EI_RS06355	COG0109	protoheme IX farnesyltransferase activity
ALE3EI_RS06360	COG1845	cytochrome c oxidase, subunit III
ALE3EI_RS06380	COG1999	signal sequence binding
ALE3EI_RS06385	COG2322	membrane
ALE3EI_RS06395	COG1136	(ABC) transporter
ALE3EI_RS06400	COG1136	(ABC) transporter
ALE3EI_RS06400	COG0577	efflux transmembrane transporter activity
ALE3EI_RS06405	COG0577	efflux transmembrane transporter activity
ALE3EI_RS06405	COG1136	(ABC) transporter
ALE3EI_RS06420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ALE3EI_RS06425	COG1214	PFAM Peptidase M22, glycoprotease
ALE3EI_RS06450	COG0668	transmembrane transport
ALE3EI_RS06455	COG1331	Highly conserved protein containing a thioredoxin domain
ALE3EI_RS06485	COG3275	phosphorelay sensor kinase activity
ALE3EI_RS06490	COG3279	Response regulator of the LytR AlgR family
ALE3EI_RS06495	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ALE3EI_RS06515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ALE3EI_RS06525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ALE3EI_RS06535	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ALE3EI_RS06540	COG0596	Alpha beta hydrolase
ALE3EI_RS06560	COG0544	peptidyl-prolyl cis-trans isomerase activity
ALE3EI_RS06570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ALE3EI_RS06600	COG1428	Deoxynucleoside kinase
ALE3EI_RS06610	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ALE3EI_RS06625	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ALE3EI_RS06690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ALE3EI_RS06705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ALE3EI_RS06715	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ALE3EI_RS06735	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ALE3EI_RS06740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ALE3EI_RS06755	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ALE3EI_RS06760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ALE3EI_RS06770	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ALE3EI_RS06780	COG0022	dehydrogenase e1 component
ALE3EI_RS06780	COG0508	dehydrogenase complex catalyzes the overall conversion of
ALE3EI_RS06785	COG4771	TonB-dependent receptor
ALE3EI_RS06790	COG0739	heme binding
ALE3EI_RS06800	COG3174	membrane
ALE3EI_RS06810	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ALE3EI_RS06815	COG1428	Deoxynucleoside kinase
ALE3EI_RS06835	COG4206	TonB-dependent receptor
ALE3EI_RS06835	COG1629	transport
ALE3EI_RS06855	COG1309	transcriptional regulator
ALE3EI_RS06860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ALE3EI_RS06865	COG3396	Phenylacetate-CoA oxygenase
ALE3EI_RS06870	COG3460	Phenylacetate-CoA oxygenase
ALE3EI_RS06875	COG3396	Phenylacetate-CoA oxygenase
ALE3EI_RS06880	COG2151	metal-sulfur cluster biosynthetic enzyme
ALE3EI_RS06890	COG1024	Enoyl-CoA hydratase
ALE3EI_RS06895	COG1250	3-hydroxyacyl-CoA dehydrogenase
ALE3EI_RS06905	COG0183	Belongs to the thiolase family
ALE3EI_RS06915	COG2030	dehydratase
ALE3EI_RS06915	COG1012	belongs to the aldehyde dehydrogenase family
ALE3EI_RS06930	COG0508	dehydrogenase complex catalyzes the overall conversion of
ALE3EI_RS06935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ALE3EI_RS06940	COG0022	dehydrogenase e1 component
ALE3EI_RS06955	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ALE3EI_RS06995	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ALE3EI_RS07000	COG0791	NLP P60 protein
ALE3EI_RS07000	COG1388	LysM domain
ALE3EI_RS07005	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ALE3EI_RS07045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ALE3EI_RS07055	COG2197	response regulator
ALE3EI_RS07060	COG0401	homolog of Blt101
ALE3EI_RS07070	COG0321	lipoyl(octanoyl) transferase activity
ALE3EI_RS07100	COG0745	RESPONSE REGULATOR receiver
ALE3EI_RS07100	COG3292	Two component regulator propeller
ALE3EI_RS07100	COG2205	protein histidine kinase activity
ALE3EI_RS07110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ALE3EI_RS07150	COG1960	acyl-CoA dehydrogenase activity
ALE3EI_RS07155	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ALE3EI_RS07170	COG0811	peptide transport
ALE3EI_RS07175	COG0848	biopolymer transport protein
ALE3EI_RS07190	COG0285	dihydrofolate synthase activity
ALE3EI_RS07205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ALE3EI_RS07210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ALE3EI_RS07225	COG0295	cytidine deaminase activity
ALE3EI_RS07230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ALE3EI_RS07240	COG1028	Short-chain dehydrogenase reductase Sdr
ALE3EI_RS07265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ALE3EI_RS07270	COG1785	Belongs to the alkaline phosphatase family
ALE3EI_RS07275	COG1216	Glycosyl transferase, family 2
ALE3EI_RS07290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ALE3EI_RS07290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ALE3EI_RS07310	COG0339	signal peptide processing
ALE3EI_RS07315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ALE3EI_RS07320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ALE3EI_RS07325	COG0563	adenylate kinase activity
ALE3EI_RS07330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ALE3EI_RS07345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ALE3EI_RS07360	COG2003	Belongs to the UPF0758 family
ALE3EI_RS07390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ALE3EI_RS07400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ALE3EI_RS07415	COG1629	transport
ALE3EI_RS07425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ALE3EI_RS07430	COG0049	tRNA binding
ALE3EI_RS07435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ALE3EI_RS07440	COG0051	transcription antitermination factor activity, RNA binding
ALE3EI_RS07445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ALE3EI_RS07450	COG0088	Forms part of the polypeptide exit tunnel
ALE3EI_RS07455	COG0089	rRNA binding
ALE3EI_RS07460	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ALE3EI_RS07465	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ALE3EI_RS07470	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ALE3EI_RS07475	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ALE3EI_RS07480	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ALE3EI_RS07485	COG0255	Belongs to the universal ribosomal protein uL29 family
ALE3EI_RS07490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ALE3EI_RS07495	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ALE3EI_RS07500	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ALE3EI_RS07505	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ALE3EI_RS07510	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ALE3EI_RS07515	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ALE3EI_RS07520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ALE3EI_RS07525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ALE3EI_RS07530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ALE3EI_RS07535	COG1841	ribosomal large subunit assembly
ALE3EI_RS07540	COG0200	Binds to the 23S rRNA
ALE3EI_RS07545	COG0201	protein transport
ALE3EI_RS07550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ALE3EI_RS07555	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ALE3EI_RS07560	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ALE3EI_RS07565	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ALE3EI_RS07570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ALE3EI_RS07575	COG0202	RNA polymerase activity
ALE3EI_RS07580	COG0203	ribosomal protein L17
ALE3EI_RS07585	COG0505	Belongs to the CarA family
ALE3EI_RS07590	COG0148	phosphopyruvate hydratase activity
ALE3EI_RS07615	COG1090	epimerase
ALE3EI_RS07625	COG0018	arginyl-trna synthetase
ALE3EI_RS07655	COG3851	Histidine kinase
ALE3EI_RS07740	COG0513	Belongs to the DEAD box helicase family
ALE3EI_RS07750	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ALE3EI_RS07755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ALE3EI_RS07760	COG3339	Conserved Protein
ALE3EI_RS07805	COG0433	COG0433 Predicted ATPase
ALE3EI_RS07810	COG0251	oxidation-reduction process
ALE3EI_RS07815	COG0602	queuosine metabolic process
ALE3EI_RS07825	COG0187	DNA topoisomerase II activity
ALE3EI_RS07840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ALE3EI_RS07850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ALE3EI_RS07855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ALE3EI_RS07860	COG0215	cysteine-tRNA ligase activity
ALE3EI_RS07865	COG0302	gtp cyclohydrolase
ALE3EI_RS07890	COG0442	prolyl-tRNA aminoacylation
ALE3EI_RS07900	COG0268	Binds directly to 16S ribosomal RNA
ALE3EI_RS07935	COG2095	MarC family integral membrane protein
ALE3EI_RS07945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ALE3EI_RS08010	COG4447	cellulose binding
ALE3EI_RS08060	COG4680	protein conserved in bacteria
ALE3EI_RS08095	COG1715	Restriction endonuclease
ALE3EI_RS08095	COG1787	Restriction endonuclease
ALE3EI_RS08170	COG4974	Belongs to the 'phage' integrase family
ALE3EI_RS08175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ALE3EI_RS08180	COG1181	Belongs to the D-alanine--D-alanine ligase family
ALE3EI_RS08190	COG0564	pseudouridine synthase activity
ALE3EI_RS08195	COG3022	response to hydroperoxide
ALE3EI_RS08230	COG0159	tryptophan synthase activity
ALE3EI_RS08235	COG0133	tryptophan synthase activity
ALE3EI_RS08240	COG0135	phosphoribosylanthranilate isomerase activity
ALE3EI_RS08245	COG0134	indole-3-glycerol-phosphate synthase activity
ALE3EI_RS08250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ALE3EI_RS08255	COG0512	Glutamine amidotransferase of anthranilate synthase
ALE3EI_RS08260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ALE3EI_RS08285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALE3EI_RS08295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ALE3EI_RS08300	COG1054	Belongs to the UPF0176 family
ALE3EI_RS08340	COG4452	Inner membrane protein CreD
ALE3EI_RS08370	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ALE3EI_RS08375	COG1217	gtp-binding protein TYPA
ALE3EI_RS08430	COG0438	transferase activity, transferring glycosyl groups
ALE3EI_RS08440	COG0463	Glycosyl transferase, family 2
ALE3EI_RS08440	COG1216	Glycosyl transferase, family 2
ALE3EI_RS08460	COG2884	Cell division ATP-binding protein ftsE
ALE3EI_RS08485	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ALE3EI_RS08520	COG3876	Protein conserved in bacteria
ALE3EI_RS08525	COG0577	efflux transmembrane transporter activity
ALE3EI_RS08550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ALE3EI_RS08555	COG1115	amino acid carrier protein
ALE3EI_RS08565	COG1960	acyl-CoA dehydrogenase activity
ALE3EI_RS08575	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ALE3EI_RS08580	COG4974	Belongs to the 'phage' integrase family
ALE3EI_RS08585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ALE3EI_RS08610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ALE3EI_RS08620	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ALE3EI_RS08630	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ALE3EI_RS08635	COG0081	regulation of translation
ALE3EI_RS08640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ALE3EI_RS08645	COG0222	ribosome binding
ALE3EI_RS08650	COG0085	RNA polymerase activity
ALE3EI_RS08655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ALE3EI_RS08675	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ALE3EI_RS08695	COG2885	chlorophyll binding
ALE3EI_RS08700	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ALE3EI_RS08710	COG1482	cell wall glycoprotein biosynthetic process
ALE3EI_RS08755	COG0326	Molecular chaperone. Has ATPase activity
ALE3EI_RS08760	COG1506	peptidase
ALE3EI_RS08760	COG0823	Involved in the tonB-independent uptake of proteins
ALE3EI_RS08765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ALE3EI_RS08780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ALE3EI_RS08790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ALE3EI_RS08800	COG0508	dehydrogenase complex catalyzes the overall conversion of
ALE3EI_RS08815	COG0179	Fumarylacetoacetate (FAA) hydrolase
ALE3EI_RS08825	COG1546	Belongs to the CinA family
ALE3EI_RS08825	COG1058	Belongs to the CinA family
ALE3EI_RS08830	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ALE3EI_RS08835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ALE3EI_RS08845	COG0552	protein localization to endoplasmic reticulum
ALE3EI_RS08855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALE3EI_RS08890	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ALE3EI_RS08895	COG0189	ligase activity
ALE3EI_RS08905	COG0519	Catalyzes the synthesis of GMP from XMP
ALE3EI_RS08905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ALE3EI_RS08925	COG3530	Putative quorum-sensing-regulated virulence factor
ALE3EI_RS08930	COG0504	CTP synthase activity
ALE3EI_RS08935	COG0706	membrane insertase activity
ALE3EI_RS08945	COG0482	sulfurtransferase activity
ALE3EI_RS08950	COG1404	Belongs to the peptidase S8 family
ALE3EI_RS08975	COG0019	diaminopimelate decarboxylase activity
ALE3EI_RS08980	COG0045	succinate-CoA ligase (ADP-forming) activity
ALE3EI_RS09000	COG0071	Belongs to the small heat shock protein (HSP20) family
ALE3EI_RS09005	COG1187	pseudouridine synthase activity
ALE3EI_RS09020	COG0556	nucleotide-excision repair
ALE3EI_RS09030	COG4106	trans-aconitate 2-methyltransferase activity
ALE3EI_RS09050	COG1131	(ABC) transporter
ALE3EI_RS09070	COG1612	heme a metabolic process
ALE3EI_RS09080	COG0517	IMP dehydrogenase activity
ALE3EI_RS09080	COG0617	tRNA 3'-terminal CCA addition
ALE3EI_RS09080	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ALE3EI_RS09085	COG0009	L-threonylcarbamoyladenylate synthase
ALE3EI_RS09100	COG0463	Glycosyl transferase, family 2
ALE3EI_RS09130	COG1215	transferase activity, transferring glycosyl groups
ALE3EI_RS09135	COG2264	protein methyltransferase activity
ALE3EI_RS09150	COG2171	N-acyltransferase activity
ALE3EI_RS09155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ALE3EI_RS09160	COG0242	peptide deformylase activity
ALE3EI_RS09170	COG3956	TIGRFAM MazG family protein
ALE3EI_RS09185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ALE3EI_RS09205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ALE3EI_RS09215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ALE3EI_RS09220	COG0735	belongs to the Fur family
ALE3EI_RS09225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ALE3EI_RS09230	COG0501	Belongs to the peptidase M48B family
ALE3EI_RS09240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ALE3EI_RS09260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ALE3EI_RS09270	COG2195	Cleaves the N-terminal amino acid of tripeptides
ALE3EI_RS09275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ALE3EI_RS09285	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ALE3EI_RS09290	COG0105	UTP biosynthetic process
ALE3EI_RS09305	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ALE3EI_RS09315	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ALE3EI_RS09325	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ALE3EI_RS09355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ALE3EI_RS09365	COG1475	DNA binding
ALE3EI_RS09370	COG1192	Involved in chromosome partitioning
ALE3EI_RS09380	COG1028	Short-chain dehydrogenase reductase Sdr
ALE3EI_RS09390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ALE3EI_RS09390	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ALE3EI_RS09400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ALE3EI_RS09410	COG0572	uridine kinase
ALE3EI_RS09415	COG2010	Cytochrome c
ALE3EI_RS09420	COG2133	pyrroloquinoline quinone binding
ALE3EI_RS09440	COG0471	metal ion transport
ALE3EI_RS09440	COG3273	potassium ion transport
ALE3EI_RS09450	COG0492	ferredoxin-NADP+ reductase activity
ALE3EI_RS09505	COG0583	DNA-binding transcription factor activity
ALE3EI_RS09515	COG0714	Associated with various cellular activities
ALE3EI_RS09550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ALE3EI_RS09575	COG1252	NADH dehydrogenase
ALE3EI_RS09590	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ALE3EI_RS09615	COG3275	phosphorelay sensor kinase activity
ALE3EI_RS09630	COG3279	Response regulator of the LytR AlgR family
ALE3EI_RS09665	COG1595	DNA-templated transcription, initiation
ALE3EI_RS09710	COG1652	LysM domain
ALE3EI_RS09710	COG2823	Periplasmic or secreted lipoprotein
ALE3EI_RS09715	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ALE3EI_RS09720	COG1228	amidohydrolase
ALE3EI_RS09765	COG1960	acyl-CoA dehydrogenase activity
ALE3EI_RS09770	COG0183	Belongs to the thiolase family
ALE3EI_RS09775	COG1024	Enoyl-CoA hydratase
ALE3EI_RS09775	COG1250	3-hydroxyacyl-CoA dehydrogenase
ALE3EI_RS09785	COG1022	Amp-dependent synthetase and ligase
ALE3EI_RS09795	COG0047	phosphoribosylformylglycinamidine synthase activity
ALE3EI_RS09795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ALE3EI_RS09810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ALE3EI_RS09810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ALE3EI_RS09835	COG1132	(ABC) transporter
ALE3EI_RS09840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ALE3EI_RS09855	COG0254	rRNA binding
ALE3EI_RS09880	COG0747	negative chemotaxis
ALE3EI_RS09890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALE3EI_RS09925	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ALE3EI_RS09930	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ALE3EI_RS09950	COG1120	ATPase activity
ALE3EI_RS09955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ALE3EI_RS09985	COG1595	DNA-templated transcription, initiation
ALE3EI_RS10020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ALE3EI_RS10040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ALE3EI_RS10055	COG1012	belongs to the aldehyde dehydrogenase family
ALE3EI_RS10065	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ALE3EI_RS10090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ALE3EI_RS10095	COG3279	Response regulator of the LytR AlgR family
ALE3EI_RS10100	COG0360	Binds together with S18 to 16S ribosomal RNA
ALE3EI_RS10105	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ALE3EI_RS10110	COG0359	binds to the 23S rRNA
ALE3EI_RS10120	COG1136	(ABC) transporter
ALE3EI_RS10120	COG0577	efflux transmembrane transporter activity
ALE3EI_RS10125	COG0124	histidyl-tRNA synthetase
ALE3EI_RS10145	COG0569	domain protein
ALE3EI_RS10175	COG4585	Histidine kinase
ALE3EI_RS10195	COG1678	Uncharacterized ACR, COG1678
ALE3EI_RS10205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ALE3EI_RS10210	COG0514	ATP-dependent DNA helicase (RecQ)
ALE3EI_RS10230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ALE3EI_RS10245	COG0415	Belongs to the DNA photolyase family
ALE3EI_RS10255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ALE3EI_RS10275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ALE3EI_RS10290	COG0424	maF-like protein
ALE3EI_RS10325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ALE3EI_RS10325	COG1333	cytochrome c biogenesis protein
ALE3EI_RS10350	COG1393	Belongs to the ArsC family
ALE3EI_RS10360	COG1846	Transcriptional regulator
ALE3EI_RS10360	COG0456	acetyltransferase
ALE3EI_RS10385	COG3422	double-strand break repair
ALE3EI_RS10390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ALE3EI_RS10405	COG0156	8-amino-7-oxononanoate synthase activity
ALE3EI_RS10410	COG0456	acetyltransferase
ALE3EI_RS10455	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ALE3EI_RS10470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ALE3EI_RS10475	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ALE3EI_RS10485	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ALE3EI_RS10510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ALE3EI_RS10520	COG4251	negative regulation of phosphorylation
ALE3EI_RS10525	COG2205	protein histidine kinase activity
ALE3EI_RS10535	COG1136	(ABC) transporter
ALE3EI_RS10545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALE3EI_RS10550	COG0302	gtp cyclohydrolase
ALE3EI_RS10560	COG4771	TonB-dependent receptor
ALE3EI_RS10585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ALE3EI_RS10590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ALE3EI_RS10600	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ALE3EI_RS10630	COG0012	GTP binding
ALE3EI_RS10660	COG2205	protein histidine kinase activity
ALE3EI_RS10660	COG0784	Response regulator, receiver
ALE3EI_RS10680	COG1522	sequence-specific DNA binding
ALE3EI_RS10685	COG0693	protein deglycase activity
ALE3EI_RS10695	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ALE3EI_RS10720	COG2169	Transcriptional regulator
ALE3EI_RS10720	COG1917	Cupin 2, conserved barrel domain protein
ALE3EI_RS10745	COG2255	four-way junction helicase activity
ALE3EI_RS10750	COG2204	response regulator
ALE3EI_RS10755	COG1078	dGTPase activity
ALE3EI_RS10760	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALE3EI_RS10765	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ALE3EI_RS10765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ALE3EI_RS10770	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALE3EI_RS10775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ALE3EI_RS10780	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALE3EI_RS10790	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ALE3EI_RS10795	COG1028	Short-chain dehydrogenase reductase Sdr
ALE3EI_RS10810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ALE3EI_RS10815	COG0052	Belongs to the universal ribosomal protein uS2 family
ALE3EI_RS10825	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ALE3EI_RS10830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ALE3EI_RS10835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ALE3EI_RS10840	COG0131	Imidazoleglycerol-phosphate dehydratase
ALE3EI_RS10840	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ALE3EI_RS10850	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ALE3EI_RS10855	COG0107	imidazoleglycerol-phosphate synthase activity
ALE3EI_RS10860	COG0140	phosphoribosyl-ATP diphosphatase activity
ALE3EI_RS10860	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ALE3EI_RS10865	COG0598	Magnesium transport protein CorA
ALE3EI_RS10895	COG1012	belongs to the aldehyde dehydrogenase family
ALE3EI_RS10915	COG0668	transmembrane transport
ALE3EI_RS10920	COG2814	Major facilitator Superfamily
ALE3EI_RS10925	COG3264	Mechanosensitive ion channel
ALE3EI_RS10925	COG1196	nuclear chromosome segregation
ALE3EI_RS10935	COG1028	Short-chain dehydrogenase reductase Sdr
ALE3EI_RS10965	COG1360	Flagellar Motor Protein
ALE3EI_RS10970	COG0668	transmembrane transport
ALE3EI_RS10975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ALE3EI_RS11040	COG1278	Cold shock
ALE3EI_RS11045	COG2169	Transcriptional regulator
ALE3EI_RS11075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ALE3EI_RS11110	COG2353	YceI-like domain
ALE3EI_RS11125	COG3590	peptidase
ALE3EI_RS11130	COG0823	Involved in the tonB-independent uptake of proteins
ALE3EI_RS11165	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ALE3EI_RS11175	COG2814	Major facilitator Superfamily
ALE3EI_RS11205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ALE3EI_RS11210	COG0861	Integral membrane protein TerC family
ALE3EI_RS11215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ALE3EI_RS11220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ALE3EI_RS11225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ALE3EI_RS11235	COG3424	synthase
ALE3EI_RS11245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ALE3EI_RS11265	COG0022	dehydrogenase e1 component
ALE3EI_RS11280	COG0813	purine-nucleoside phosphorylase activity
ALE3EI_RS11290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ALE3EI_RS11300	COG3011	Protein conserved in bacteria
ALE3EI_RS11315	COG0189	ligase activity
ALE3EI_RS11325	COG1301	dicarboxylic acid transport
ALE3EI_RS11330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ALE3EI_RS11340	COG0277	FAD linked oxidase domain protein
ALE3EI_RS11340	COG0247	lactate metabolic process
ALE3EI_RS11360	COG0438	transferase activity, transferring glycosyl groups
ALE3EI_RS11365	COG1472	Belongs to the glycosyl hydrolase 3 family
ALE3EI_RS11375	COG0247	lactate metabolic process
ALE3EI_RS11375	COG2181	nitrate reductase activity
ALE3EI_RS11385	COG2181	nitrate reductase activity
ALE3EI_RS11385	COG0247	lactate metabolic process
ALE3EI_RS11395	COG0860	N-Acetylmuramoyl-L-alanine amidase
ALE3EI_RS11405	COG0251	oxidation-reduction process
ALE3EI_RS11415	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ALE3EI_RS11435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ALE3EI_RS11500	COG3685	Protein conserved in bacteria
ALE3EI_RS11505	COG0745	RESPONSE REGULATOR receiver
ALE3EI_RS11505	COG3292	Two component regulator propeller
ALE3EI_RS11505	COG2205	protein histidine kinase activity
ALE3EI_RS11520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ALE3EI_RS11530	COG0183	Belongs to the thiolase family
ALE3EI_RS11535	COG0791	NLP P60 protein
ALE3EI_RS11540	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ALE3EI_RS11540	COG0457	Tetratricopeptide repeat
ALE3EI_RS11550	COG0542	response to heat
ALE3EI_RS11570	COG2986	histidine ammonia-lyase
ALE3EI_RS11575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALE3EI_RS11580	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ALE3EI_RS11580	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ALE3EI_RS11585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ALE3EI_RS11595	COG2154	pterin-4-alpha-carbinolamine dehydratase
ALE3EI_RS11600	COG0793	Belongs to the peptidase S41A family
ALE3EI_RS11605	COG0217	transcriptional regulatory protein
ALE3EI_RS11620	COG1454	alcohol dehydrogenase
ALE3EI_RS11630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ALE3EI_RS11660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ALE3EI_RS11680	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ALE3EI_RS11690	COG0259	pyridoxamine-phosphate oxidase activity
ALE3EI_RS11700	COG1234	tRNA 3'-trailer cleavage
ALE3EI_RS11710	COG0540	Belongs to the ATCase OTCase family
ALE3EI_RS11715	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ALE3EI_RS11730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ALE3EI_RS11740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ALE3EI_RS11745	COG1595	DNA-templated transcription, initiation
ALE3EI_RS11770	COG2270	Major facilitator Superfamily
ALE3EI_RS11785	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALE3EI_RS11790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALE3EI_RS11795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ALE3EI_RS11800	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ALE3EI_RS11825	COG4974	Belongs to the 'phage' integrase family
ALE3EI_RS11830	COG0656	L-ascorbic acid biosynthetic process
ALE3EI_RS11835	COG1418	mRNA catabolic process
ALE3EI_RS11865	COG1104	cysteine desulfurase activity
ALE3EI_RS11895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ALE3EI_RS11900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ALE3EI_RS11915	COG0116	Belongs to the methyltransferase superfamily
ALE3EI_RS11915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ALE3EI_RS11930	COG1272	protein, Hemolysin III
ALE3EI_RS11975	COG1363	Peptidase, m42
ALE3EI_RS12000	COG1115	amino acid carrier protein
ALE3EI_RS12010	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ALE3EI_RS12015	COG1702	phosphate starvation-inducible protein PhoH
ALE3EI_RS12040	COG0592	DNA-directed DNA polymerase activity
ALE3EI_RS12045	COG0596	Alpha beta hydrolase
ALE3EI_RS12050	COG2205	protein histidine kinase activity
ALE3EI_RS12050	COG0784	Response regulator, receiver
ALE3EI_RS12070	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ALE3EI_RS12095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ALE3EI_RS12105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ALE3EI_RS12115	COG0438	transferase activity, transferring glycosyl groups
ALE3EI_RS12140	COG0367	asparagine synthase
ALE3EI_RS12145	COG0110	maltose O-acetyltransferase activity
ALE3EI_RS12150	COG2244	polysaccharide biosynthetic process
ALE3EI_RS12160	COG1215	transferase activity, transferring glycosyl groups
ALE3EI_RS12175	COG2244	polysaccharide biosynthetic process
ALE3EI_RS12185	COG0175	sulfate reduction
ALE3EI_RS12190	COG0529	Catalyzes the synthesis of activated sulfate
ALE3EI_RS12205	COG0783	Belongs to the Dps family
ALE3EI_RS12240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALE3EI_RS12250	COG0705	Rhomboid family
ALE3EI_RS12260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ALE3EI_RS12270	COG0405	Gamma-glutamyltransferase
ALE3EI_RS12280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ALE3EI_RS12285	COG1611	Belongs to the LOG family
ALE3EI_RS12300	COG0022	dehydrogenase e1 component
ALE3EI_RS12310	COG0367	asparagine synthase
ALE3EI_RS12320	COG2197	response regulator
ALE3EI_RS12345	COG2996	Protein conserved in bacteria
ALE3EI_RS12355	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ALE3EI_RS12360	COG1169	isochorismate synthase
ALE3EI_RS12365	COG2050	protein possibly involved in aromatic compounds catabolism
ALE3EI_RS12380	COG0385	Bile acid
ALE3EI_RS12440	COG0443	Heat shock 70 kDa protein
ALE3EI_RS12445	COG0587	DNA-directed DNA polymerase activity
ALE3EI_RS12450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ALE3EI_RS12455	COG2135	peptidase activity
ALE3EI_RS12460	COG1760	l-serine dehydratase
ALE3EI_RS12470	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ALE3EI_RS12475	COG0564	pseudouridine synthase activity
ALE3EI_RS12485	COG4585	Histidine kinase
ALE3EI_RS12505	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ALE3EI_RS12515	COG1914	H( )-stimulated, divalent metal cation uptake system
ALE3EI_RS12520	COG0612	Peptidase, M16
ALE3EI_RS12525	COG0606	chelatase, subunit chli
ALE3EI_RS12530	COG2197	response regulator
ALE3EI_RS12535	COG4585	Histidine kinase
ALE3EI_RS12550	COG0166	Belongs to the GPI family
ALE3EI_RS12565	COG0205	6-phosphofructokinase activity
ALE3EI_RS12580	COG0037	tRNA processing
ALE3EI_RS12585	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ALE3EI_RS12600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ALE3EI_RS12635	COG1757	Na H antiporter
ALE3EI_RS12640	COG0450	alkyl hydroperoxide reductase
ALE3EI_RS12645	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ALE3EI_RS12660	COG1674	ftsk spoiiie
ALE3EI_RS12675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ALE3EI_RS12675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ALE3EI_RS12690	COG0745	RESPONSE REGULATOR receiver
ALE3EI_RS12690	COG3292	Two component regulator propeller
ALE3EI_RS12690	COG2205	protein histidine kinase activity
ALE3EI_RS12695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ALE3EI_RS12720	COG0589	response to stress
ALE3EI_RS12760	COG0589	response to stress
ALE3EI_RS12780	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ALE3EI_RS12805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ALE3EI_RS12810	COG0589	response to stress
ALE3EI_RS12820	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ALE3EI_RS12825	COG4263	nitrous-oxide reductase activity
ALE3EI_RS12850	COG1131	(ABC) transporter
ALE3EI_RS12900	COG2217	Heavy metal translocating P-type atpase
ALE3EI_RS12910	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ALE3EI_RS12925	COG2132	Multicopper oxidase
ALE3EI_RS12940	COG0701	Predicted permease
ALE3EI_RS12945	COG2217	Heavy metal translocating P-type atpase
ALE3EI_RS13055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ALE3EI_RS13060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALE3EI_RS13080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ALE3EI_RS13080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ALE3EI_RS13100	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ALE3EI_RS13105	COG0626	cystathionine gamma-synthase activity
ALE3EI_RS13110	COG1228	amidohydrolase
ALE3EI_RS13115	COG0010	Belongs to the arginase family
ALE3EI_RS13140	COG4771	TonB-dependent receptor
ALE3EI_RS13155	COG0823	Involved in the tonB-independent uptake of proteins
ALE3EI_RS13155	COG4946	Tricorn protease homolog
ALE3EI_RS13155	COG1506	peptidase
ALE3EI_RS13165	COG0488	(ABC) transporter
ALE3EI_RS13175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ALE3EI_RS13195	COG1629	transport
ALE3EI_RS13210	COG4948	Mandelate Racemase Muconate Lactonizing
ALE3EI_RS13215	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ALE3EI_RS13220	COG1575	Belongs to the MenA family. Type 1 subfamily
ALE3EI_RS13265	COG0009	L-threonylcarbamoyladenylate synthase
ALE3EI_RS13280	COG1473	amidohydrolase
ALE3EI_RS13285	COG0069	glutamate synthase activity
ALE3EI_RS13290	COG3279	Response regulator of the LytR AlgR family
ALE3EI_RS13295	COG3275	phosphorelay sensor kinase activity
ALE3EI_RS13320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ALE3EI_RS13355	COG0488	(ABC) transporter
ALE3EI_RS13365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ALE3EI_RS13370	COG0300	oxidoreductase activity
ALE3EI_RS13395	COG1278	Cold shock
ALE3EI_RS13405	COG1858	cytochrome C peroxidase
ALE3EI_RS13420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ALE3EI_RS13440	COG0542	response to heat
ALE3EI_RS13480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ALE3EI_RS13485	COG4771	TonB-dependent receptor
ALE3EI_RS13500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ALE3EI_RS13505	COG0673	inositol 2-dehydrogenase activity
ALE3EI_RS13510	COG1250	3-hydroxyacyl-CoA dehydrogenase
ALE3EI_RS13520	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ALE3EI_RS13530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ALE3EI_RS13535	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ALE3EI_RS13550	COG0237	dephospho-CoA kinase activity
ALE3EI_RS13560	COG0463	Glycosyl transferase, family 2
ALE3EI_RS13575	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ALE3EI_RS13580	COG0497	DNA recombination
ALE3EI_RS13605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ALE3EI_RS13615	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ALE3EI_RS13620	COG1611	Belongs to the LOG family
ALE3EI_RS13625	COG2890	protein-(glutamine-N5) methyltransferase activity
ALE3EI_RS13635	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ALE3EI_RS13635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ALE3EI_RS13640	COG0697	spore germination
ALE3EI_RS13645	COG1739	Uncharacterized protein family UPF0029