locus-tag	class	description
Ami3637_RS00025	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Ami3637_RS00035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ami3637_RS00035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ami3637_RS00065	COG3290	protein histidine kinase activity
Ami3637_RS00065	COG3829	transcription factor binding
Ami3637_RS00080	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Ami3637_RS00085	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Ami3637_RS00090	COG1959	2 iron, 2 sulfur cluster binding
Ami3637_RS00115	COG1733	regulation of RNA biosynthetic process
Ami3637_RS00160	COG0531	amino acid
Ami3637_RS00185	COG0583	DNA-binding transcription factor activity
Ami3637_RS00200	COG0531	amino acid
Ami3637_RS00205	COG1012	belongs to the aldehyde dehydrogenase family
Ami3637_RS00210	COG0789	Transcriptional regulator
Ami3637_RS00230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Ami3637_RS00255	COG3279	Response regulator of the LytR AlgR family
Ami3637_RS00260	COG0693	protein deglycase activity
Ami3637_RS00275	COG0095	Lipoate-protein ligase
Ami3637_RS00280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Ami3637_RS00290	COG1846	Transcriptional regulator
Ami3637_RS00400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Ami3637_RS00410	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Ami3637_RS00415	COG2385	sporulation resulting in formation of a cellular spore
Ami3637_RS00430	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Ami3637_RS00435	COG1438	arginine binding
Ami3637_RS00440	COG0497	DNA recombination
Ami3637_RS00455	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Ami3637_RS00460	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Ami3637_RS00460	COG0539	negative regulation of cytoplasmic translation
Ami3637_RS00465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Ami3637_RS00520	COG4651	solute:proton antiporter activity
Ami3637_RS00520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Ami3637_RS00525	COG5002	protein histidine kinase activity
Ami3637_RS00530	COG0745	RESPONSE REGULATOR receiver
Ami3637_RS00535	COG1283	sodium-dependent phosphate transmembrane transporter activity
Ami3637_RS00545	COG0740	serine-type endopeptidase activity
Ami3637_RS00555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Ami3637_RS00555	COG0574	Belongs to the PEP-utilizing enzyme family
Ami3637_RS00565	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Ami3637_RS00575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Ami3637_RS00580	COG0295	cytidine deaminase activity
Ami3637_RS00590	COG1702	phosphate starvation-inducible protein PhoH
Ami3637_RS00595	COG0561	phosphatase activity
Ami3637_RS00610	COG1959	2 iron, 2 sulfur cluster binding
Ami3637_RS00620	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Ami3637_RS00625	COG0537	adenosine 5'-monophosphoramidase activity
Ami3637_RS00630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Ami3637_RS00640	COG0726	polysaccharide deacetylase
Ami3637_RS00640	COG1649	PFAM Uncharacterised BCR, COG1649
Ami3637_RS00650	COG2033	superoxide reductase activity
Ami3637_RS00655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Ami3637_RS00660	COG2264	protein methyltransferase activity
Ami3637_RS00665	COG4978	Transcriptional regulator
Ami3637_RS00665	COG0789	Transcriptional regulator
Ami3637_RS00670	COG2211	Major facilitator Superfamily
Ami3637_RS00675	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Ami3637_RS00680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Ami3637_RS00700	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Ami3637_RS00720	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Ami3637_RS00725	COG1254	Belongs to the acylphosphatase family
Ami3637_RS00755	COG3260	NADH ubiquinone oxidoreductase 20
Ami3637_RS00765	COG2111	Na H antiporter
Ami3637_RS00765	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Ami3637_RS00775	COG0444	Belongs to the ABC transporter superfamily
Ami3637_RS00780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ami3637_RS00785	COG0601	transmembrane transport
Ami3637_RS00810	COG1937	Protein conserved in bacteria
Ami3637_RS00845	COG4302	ethanolamine ammonia-lyase activity
Ami3637_RS00855	COG3920	Histidine kinase
Ami3637_RS00860	COG2197	response regulator
Ami3637_RS00885	COG4869	propanediol catabolic process
Ami3637_RS00890	COG1012	belongs to the aldehyde dehydrogenase family
Ami3637_RS00890	COG1454	alcohol dehydrogenase
Ami3637_RS00910	COG4656	Part of a membrane complex involved in electron transport
Ami3637_RS00925	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Ami3637_RS00935	COG4816	utilization protein
Ami3637_RS00955	COG1250	3-hydroxyacyl-CoA dehydrogenase
Ami3637_RS00965	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Ami3637_RS00965	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Ami3637_RS00970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Ami3637_RS00975	COG1418	mRNA catabolic process
Ami3637_RS00990	COG0443	Heat shock 70 kDa protein
Ami3637_RS01020	COG0559	Belongs to the binding-protein-dependent transport system permease family
Ami3637_RS01045	COG1115	amino acid carrier protein
Ami3637_RS01080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ami3637_RS01100	COG0481	GTPase activity
Ami3637_RS01115	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Ami3637_RS01120	COG0268	Binds directly to 16S ribosomal RNA
Ami3637_RS01125	COG2207	Transcriptional regulator
Ami3637_RS01125	COG1917	Cupin 2, conserved barrel domain protein
Ami3637_RS01140	COG2235	arginine
Ami3637_RS01145	COG3835	regulator
Ami3637_RS01160	COG3949	Membrane
Ami3637_RS01165	COG2962	Rard protein
Ami3637_RS01170	COG1757	Na H antiporter
Ami3637_RS01185	COG1164	Oligoendopeptidase f
Ami3637_RS01190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Ami3637_RS01195	COG0564	pseudouridine synthase activity
Ami3637_RS01200	COG0840	transmembrane signaling receptor activity
Ami3637_RS01225	COG0514	ATP-dependent DNA helicase (RecQ)
Ami3637_RS01265	COG0583	DNA-binding transcription factor activity
Ami3637_RS01280	COG1695	Transcriptional regulator
Ami3637_RS01305	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Ami3637_RS01330	COG1733	regulation of RNA biosynthetic process
Ami3637_RS01355	COG2949	membrane
Ami3637_RS01365	COG0617	tRNA 3'-terminal CCA addition
Ami3637_RS01375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Ami3637_RS01380	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Ami3637_RS01415	COG2340	Cysteine-rich secretory protein family
Ami3637_RS01420	COG0494	nUDIX hydrolase
Ami3637_RS01425	COG0697	spore germination
Ami3637_RS01440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Ami3637_RS01465	COG4496	protein, YerC YecD
Ami3637_RS01470	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
Ami3637_RS01500	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Ami3637_RS01510	COG4869	propanediol catabolic process
Ami3637_RS01520	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Ami3637_RS01555	COG2207	Transcriptional regulator
Ami3637_RS01565	COG0793	Belongs to the peptidase S41A family
Ami3637_RS01570	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Ami3637_RS01570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Ami3637_RS01575	COG0739	heme binding
Ami3637_RS01580	COG2177	Part of the ABC transporter FtsEX involved in
Ami3637_RS01585	COG2884	Cell division ATP-binding protein ftsE
Ami3637_RS01605	COG3958	Transketolase
Ami3637_RS01610	COG3959	Transketolase, thiamine diphosphate binding domain
Ami3637_RS01635	COG2337	Toxic component of a toxin-antitoxin (TA) module
Ami3637_RS01640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Ami3637_RS01640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Ami3637_RS01645	COG2239	Acts as a magnesium transporter
Ami3637_RS01665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Ami3637_RS01670	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Ami3637_RS01675	COG0668	transmembrane transport
Ami3637_RS01685	COG1397	ADP-ribosylglycohydrolase
Ami3637_RS01690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ami3637_RS01695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ami3637_RS01705	COG1177	transmembrane transport
Ami3637_RS01710	COG1176	ABC-type spermidine putrescine transport system, permease component I
Ami3637_RS01720	COG2204	response regulator
Ami3637_RS01725	COG0531	amino acid
Ami3637_RS01730	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Ami3637_RS01735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Ami3637_RS01780	COG0438	transferase activity, transferring glycosyl groups
Ami3637_RS01825	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Ami3637_RS01855	COG1361	Conserved repeat domain
Ami3637_RS01900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ami3637_RS01905	COG3830	Belongs to the UPF0237 family
Ami3637_RS01910	COG2848	UPF0210 protein
Ami3637_RS01930	COG3246	L-lysine catabolic process to acetate
Ami3637_RS01935	COG1660	Displays ATPase and GTPase activities
Ami3637_RS01945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Ami3637_RS01960	COG1285	pathogenesis
Ami3637_RS01975	COG3437	response regulator, receiver
Ami3637_RS01985	COG4999	Histidine kinase
Ami3637_RS01985	COG2205	protein histidine kinase activity
Ami3637_RS01985	COG3437	response regulator, receiver
Ami3637_RS01985	COG3850	Histidine kinase
Ami3637_RS02070	COG1192	Involved in chromosome partitioning
Ami3637_RS02145	COG0426	domain, Protein
Ami3637_RS02150	COG1960	acyl-CoA dehydrogenase activity
Ami3637_RS02195	COG2323	membrane
Ami3637_RS02205	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Ami3637_RS02210	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Ami3637_RS02215	COG0776	regulation of translation
Ami3637_RS02220	COG3956	TIGRFAM MazG family protein
Ami3637_RS02225	COG2244	polysaccharide biosynthetic process
Ami3637_RS02230	COG0402	S-adenosylhomocysteine deaminase activity
Ami3637_RS02235	COG2002	toxin-antitoxin pair type II binding
Ami3637_RS02240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Ami3637_RS02245	COG0193	aminoacyl-tRNA hydrolase activity
Ami3637_RS02255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Ami3637_RS02260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Ami3637_RS02265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Ami3637_RS02270	COG2088	sporulation resulting in formation of a cellular spore
Ami3637_RS02275	COG0492	ferredoxin-NADP+ reductase activity
Ami3637_RS02290	COG0741	lytic transglycosylase activity
Ami3637_RS02305	COG0768	penicillin binding
Ami3637_RS02315	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Ami3637_RS02320	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Ami3637_RS02330	COG1595	DNA-templated transcription, initiation
Ami3637_RS02340	COG0450	alkyl hydroperoxide reductase
Ami3637_RS02360	COG0167	dihydroorotate dehydrogenase activity
Ami3637_RS02365	COG0543	2 iron, 2 sulfur cluster binding
Ami3637_RS02370	COG0284	orotidine-5'-phosphate decarboxylase activity
Ami3637_RS02375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Ami3637_RS02395	COG0019	diaminopimelate decarboxylase activity
Ami3637_RS02465	COG4187	Peptidase family M20/M25/M40
Ami3637_RS02485	COG1074	ATP-dependent DNA helicase activity
Ami3637_RS02490	COG1074	ATP-dependent DNA helicase activity
Ami3637_RS02550	COG2195	Cleaves the N-terminal amino acid of tripeptides
Ami3637_RS02570	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Ami3637_RS02575	COG2081	HI0933 family
Ami3637_RS02580	COG1408	metallophosphoesterase
Ami3637_RS02600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Ami3637_RS02605	COG0513	Belongs to the DEAD box helicase family
Ami3637_RS02620	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Ami3637_RS02630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Ami3637_RS02640	COG0803	Belongs to the bacterial solute-binding protein 9 family
Ami3637_RS02670	COG1994	Peptidase M50
Ami3637_RS02675	COG0791	NLP P60 protein
Ami3637_RS02675	COG1388	LysM domain
Ami3637_RS02680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Ami3637_RS02725	COG0010	Belongs to the arginase family
Ami3637_RS02730	COG0640	Transcriptional regulator
Ami3637_RS02735	COG0701	Predicted permease
Ami3637_RS02760	COG0475	glutathione-regulated potassium exporter activity
Ami3637_RS02775	COG0189	ligase activity
Ami3637_RS02810	COG3426	butyrate kinase activity
Ami3637_RS02815	COG0280	phosphate acetyltransferase
Ami3637_RS02830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Ami3637_RS02865	COG3778	Protein conserved in bacteria
Ami3637_RS02870	COG3299	homolog of phage Mu protein gp47
Ami3637_RS02995	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Ami3637_RS03000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Ami3637_RS03005	COG1160	GTP binding
Ami3637_RS03010	COG0552	protein localization to endoplasmic reticulum
Ami3637_RS03015	COG1196	nuclear chromosome segregation
Ami3637_RS03055	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Ami3637_RS03065	COG0833	amino acid
Ami3637_RS03075	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Ami3637_RS03080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Ami3637_RS03085	COG1686	Belongs to the peptidase S11 family
Ami3637_RS03105	COG1473	amidohydrolase
Ami3637_RS03125	COG2715	membrane protein required for spore maturation
Ami3637_RS03130	COG0700	Nucleoside recognition
Ami3637_RS03135	COG1619	proteins homologs of microcin C7 resistance protein MccF
Ami3637_RS03150	COG0765	amino acid transport
Ami3637_RS03155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ami3637_RS03165	COG0726	polysaccharide deacetylase
Ami3637_RS03180	COG1597	lipid kinase activity
Ami3637_RS03190	COG0285	dihydrofolate synthase activity
Ami3637_RS03195	COG0525	valine-tRNA ligase activity
Ami3637_RS03205	COG2199	diguanylate cyclase activity
Ami3637_RS03205	COG2203	Gaf domain
Ami3637_RS03220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Ami3637_RS03220	COG1648	precorrin-2 dehydrogenase activity
Ami3637_RS03225	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Ami3637_RS03245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Ami3637_RS03250	COG0113	porphobilinogen synthase activity
Ami3637_RS03255	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Ami3637_RS03260	COG3404	Formiminotransferase-cyclodeaminase
Ami3637_RS03265	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Ami3637_RS03270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Ami3637_RS03280	COG0335	large ribosomal subunit rRNA binding
Ami3637_RS03285	COG4974	Belongs to the 'phage' integrase family
Ami3637_RS03295	COG0494	nUDIX hydrolase
Ami3637_RS03300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Ami3637_RS03305	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Ami3637_RS03320	COG0375	protein maturation
Ami3637_RS03335	COG0488	(ABC) transporter
Ami3637_RS03345	COG2359	stage V sporulation protein S
Ami3637_RS03360	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Ami3637_RS03405	COG4869	propanediol catabolic process
Ami3637_RS03410	COG1012	belongs to the aldehyde dehydrogenase family
Ami3637_RS03410	COG1454	alcohol dehydrogenase
Ami3637_RS03430	COG4656	Part of a membrane complex involved in electron transport
Ami3637_RS03460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Ami3637_RS03465	COG1882	Formate acetyltransferase
Ami3637_RS03470	COG1454	alcohol dehydrogenase
Ami3637_RS03470	COG1012	belongs to the aldehyde dehydrogenase family
Ami3637_RS03475	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Ami3637_RS03500	COG4978	Transcriptional regulator
Ami3637_RS03500	COG0789	Transcriptional regulator
Ami3637_RS03515	COG2207	Transcriptional regulator
Ami3637_RS03515	COG3708	Transcriptional regulator
Ami3637_RS03520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Ami3637_RS03525	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Ami3637_RS03555	COG0583	DNA-binding transcription factor activity
Ami3637_RS03560	COG1132	(ABC) transporter
Ami3637_RS03565	COG1132	(ABC) transporter
Ami3637_RS03580	COG0436	Aminotransferase
Ami3637_RS03630	COG0084	hydrolase, TatD family'
Ami3637_RS03635	COG1116	anion transmembrane transporter activity
Ami3637_RS03645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Ami3637_RS03655	COG0288	reversible hydration of carbon dioxide
Ami3637_RS03665	COG1177	transmembrane transport
Ami3637_RS03670	COG1176	ABC-type spermidine putrescine transport system, permease component I
Ami3637_RS03675	COG3842	ATPase activity
Ami3637_RS03710	COG1595	DNA-templated transcription, initiation
Ami3637_RS03720	COG0697	spore germination
Ami3637_RS03740	COG1151	hydroxylamine reductase activity
Ami3637_RS03785	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Ami3637_RS03795	COG0598	Magnesium transport protein CorA
Ami3637_RS03815	COG2972	Histidine kinase
Ami3637_RS03815	COG0745	RESPONSE REGULATOR receiver
Ami3637_RS03825	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Ami3637_RS03850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ami3637_RS03855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Ami3637_RS03860	COG1116	anion transmembrane transporter activity
Ami3637_RS03890	COG3620	sequence-specific DNA binding
Ami3637_RS03905	COG5002	protein histidine kinase activity
Ami3637_RS03905	COG3850	Histidine kinase
Ami3637_RS03910	COG0745	RESPONSE REGULATOR receiver
Ami3637_RS03930	COG3706	GGDEF domain
Ami3637_RS03935	COG0071	Belongs to the small heat shock protein (HSP20) family
Ami3637_RS03940	COG0412	Dienelactone hydrolase
Ami3637_RS03960	COG1595	DNA-templated transcription, initiation
Ami3637_RS03975	COG0745	RESPONSE REGULATOR receiver
Ami3637_RS03990	COG2217	Heavy metal translocating P-type atpase
Ami3637_RS03995	COG2608	mercury ion transmembrane transporter activity
Ami3637_RS04015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Ami3637_RS04020	COG1113	amino acid transport
Ami3637_RS04030	COG0833	amino acid
Ami3637_RS04045	COG0789	Transcriptional regulator
Ami3637_RS04065	COG0840	transmembrane signaling receptor activity
Ami3637_RS04080	COG1595	DNA-templated transcription, initiation
Ami3637_RS04100	COG0105	UTP biosynthetic process
Ami3637_RS04105	COG1691	(AIR) carboxylase
Ami3637_RS04145	COG0531	amino acid
Ami3637_RS04150	COG1113	amino acid transport
Ami3637_RS04170	COG1360	Flagellar Motor Protein
Ami3637_RS04175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Ami3637_RS04195	COG0789	Transcriptional regulator
Ami3637_RS04215	COG1733	regulation of RNA biosynthetic process
Ami3637_RS04250	COG1846	Transcriptional regulator
Ami3637_RS04300	COG0840	transmembrane signaling receptor activity
Ami3637_RS04305	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Ami3637_RS04305	COG2199	diguanylate cyclase activity
Ami3637_RS04310	COG0488	(ABC) transporter
Ami3637_RS04320	COG0655	NAD(P)H dehydrogenase (quinone) activity
Ami3637_RS04345	COG1595	DNA-templated transcription, initiation
Ami3637_RS04365	COG0642	Histidine kinase
Ami3637_RS04365	COG5002	protein histidine kinase activity
Ami3637_RS04370	COG0745	RESPONSE REGULATOR receiver
Ami3637_RS04380	COG0745	RESPONSE REGULATOR receiver
Ami3637_RS04385	COG2205	protein histidine kinase activity
Ami3637_RS04400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Ami3637_RS04405	COG2364	Membrane
Ami3637_RS04450	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Ami3637_RS04455	COG0824	Thioesterase
Ami3637_RS04475	COG3655	Transcriptional regulator
Ami3637_RS04525	COG0708	Exodeoxyribonuclease III
Ami3637_RS04555	COG2203	Gaf domain
Ami3637_RS04555	COG2199	diguanylate cyclase activity
Ami3637_RS04570	COG0583	DNA-binding transcription factor activity
Ami3637_RS04575	COG0697	spore germination
Ami3637_RS04625	COG3546	catalase activity
Ami3637_RS04680	COG0438	transferase activity, transferring glycosyl groups
Ami3637_RS04715	COG2873	o-acetylhomoserine
Ami3637_RS04725	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
Ami3637_RS04730	COG0551	DNA topoisomerase type I activity
Ami3637_RS04730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Ami3637_RS04740	COG1388	LysM domain
Ami3637_RS04740	COG3858	chitin binding
Ami3637_RS04745	COG3266	domain, Protein
Ami3637_RS04745	COG2911	Protein conserved in bacteria
Ami3637_RS04745	COG1361	Conserved repeat domain
Ami3637_RS04760	COG3647	Membrane
Ami3637_RS04785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Ami3637_RS04805	COG2508	Transcriptional regulator
Ami3637_RS04815	COG1361	Conserved repeat domain
Ami3637_RS04815	COG2911	Protein conserved in bacteria
Ami3637_RS04815	COG3266	domain, Protein
Ami3637_RS04820	COG2234	aminopeptidase activity
Ami3637_RS04830	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Ami3637_RS04835	COG0726	polysaccharide deacetylase
Ami3637_RS04835	COG1649	PFAM Uncharacterised BCR, COG1649
Ami3637_RS04840	COG0745	RESPONSE REGULATOR receiver
Ami3637_RS04845	COG5002	protein histidine kinase activity
Ami3637_RS04855	COG1131	(ABC) transporter
Ami3637_RS04865	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Ami3637_RS04880	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Ami3637_RS04905	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Ami3637_RS04915	COG2203	Gaf domain
Ami3637_RS04915	COG3706	GGDEF domain
Ami3637_RS04915	COG5001	Diguanylate cyclase
Ami3637_RS04915	COG4251	negative regulation of phosphorylation
Ami3637_RS04925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Ami3637_RS04980	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Ami3637_RS04995	COG2385	sporulation resulting in formation of a cellular spore
Ami3637_RS05000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Ami3637_RS05045	COG3764	Sortase (surface protein transpeptidase)
Ami3637_RS05060	COG4869	propanediol catabolic process
Ami3637_RS05075	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Ami3637_RS05080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Ami3637_RS05085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Ami3637_RS05095	COG0544	peptidyl-prolyl cis-trans isomerase activity
Ami3637_RS05100	COG3025	triphosphatase activity
Ami3637_RS05130	COG3279	Response regulator of the LytR AlgR family
Ami3637_RS05140	COG1404	Belongs to the peptidase S8 family
Ami3637_RS05165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Ami3637_RS05175	COG0484	heat shock protein binding
Ami3637_RS05190	COG1827	regulation of RNA biosynthetic process
Ami3637_RS05195	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Ami3637_RS05200	COG0493	'glutamate synthase
Ami3637_RS05215	COG2878	Part of a membrane complex involved in electron transport
Ami3637_RS05215	COG1245	4Fe-4S binding domain
Ami3637_RS05225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Ami3637_RS05235	COG1288	antiporter activity
Ami3637_RS05240	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Ami3637_RS05275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Ami3637_RS05285	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Ami3637_RS05300	COG0203	ribosomal protein L17
Ami3637_RS05310	COG0202	RNA polymerase activity
Ami3637_RS05315	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Ami3637_RS05320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Ami3637_RS05325	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Ami3637_RS05330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Ami3637_RS05335	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Ami3637_RS05345	COG0563	adenylate kinase activity
Ami3637_RS05350	COG0201	protein transport
Ami3637_RS05355	COG0200	Binds to the 23S rRNA
Ami3637_RS05360	COG1841	ribosomal large subunit assembly
Ami3637_RS05365	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Ami3637_RS05370	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Ami3637_RS05375	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Ami3637_RS05380	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Ami3637_RS05385	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Ami3637_RS05390	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Ami3637_RS05395	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Ami3637_RS05400	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Ami3637_RS05405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Ami3637_RS05410	COG0255	Belongs to the universal ribosomal protein uL29 family
Ami3637_RS05415	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Ami3637_RS05420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Ami3637_RS05425	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Ami3637_RS05430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Ami3637_RS05440	COG0089	rRNA binding
Ami3637_RS05445	COG0088	Forms part of the polypeptide exit tunnel
Ami3637_RS05455	COG0051	transcription antitermination factor activity, RNA binding
Ami3637_RS05460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ami3637_RS05470	COG2155	Conserved Protein
Ami3637_RS05480	COG0613	PHP domain protein
Ami3637_RS05485	COG0587	DNA-directed DNA polymerase activity
Ami3637_RS05490	COG0693	protein deglycase activity
Ami3637_RS05540	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Ami3637_RS05560	COG3437	response regulator, receiver
Ami3637_RS05570	COG1776	CheC inhibitor of MCP methylation
Ami3637_RS05580	COG4786	Flagellar basal body rod
Ami3637_RS05585	COG4786	Flagellar basal body rod
Ami3637_RS05600	COG1815	bacterial-type flagellum-dependent cell motility
Ami3637_RS05605	COG3266	domain, Protein
Ami3637_RS05605	COG2911	Protein conserved in bacteria
Ami3637_RS05605	COG1361	Conserved repeat domain
Ami3637_RS05610	COG0643	Histidine kinase
Ami3637_RS05610	COG2198	Histidine kinase
Ami3637_RS05620	COG2201	protein-glutamate methylesterase activity
Ami3637_RS05640	COG4786	Flagellar basal body rod
Ami3637_RS05640	COG1256	bacterial-type flagellum assembly
Ami3637_RS05675	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Ami3637_RS05695	COG1216	Glycosyl transferase, family 2
Ami3637_RS05700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Ami3637_RS05705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Ami3637_RS05710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Ami3637_RS05715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Ami3637_RS05730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ami3637_RS05735	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Ami3637_RS05750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Ami3637_RS05770	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Ami3637_RS05785	COG1338	Plays a role in the flagellum-specific transport system
Ami3637_RS05785	COG3190	flagellar
Ami3637_RS05795	COG2201	protein-glutamate methylesterase activity
Ami3637_RS05800	COG1776	CheC inhibitor of MCP methylation
Ami3637_RS05800	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Ami3637_RS05810	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Ami3637_RS05820	COG4786	Flagellar basal body rod
Ami3637_RS05830	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Ami3637_RS05845	COG1157	protein secretion by the type III secretion system
Ami3637_RS05855	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Ami3637_RS05860	COG1766	The M ring may be actively involved in energy transduction
Ami3637_RS05870	COG1558	bacterial-type flagellum-dependent cell motility
Ami3637_RS05885	COG3906	Belongs to the UPF0473 family
Ami3637_RS05890	COG0322	excinuclease ABC activity
Ami3637_RS05895	COG1686	Belongs to the peptidase S11 family
Ami3637_RS05900	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Ami3637_RS05910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Ami3637_RS05925	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Ami3637_RS05930	COG1971	Probably functions as a manganese efflux pump
Ami3637_RS05940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Ami3637_RS06005	COG1803	Methylglyoxal synthase
Ami3637_RS06015	COG0726	polysaccharide deacetylase
Ami3637_RS06025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Ami3637_RS06040	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Ami3637_RS06065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Ami3637_RS06075	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Ami3637_RS06090	COG1040	competence protein
Ami3637_RS06095	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Ami3637_RS06115	COG5002	protein histidine kinase activity
Ami3637_RS06130	COG0577	efflux transmembrane transporter activity
Ami3637_RS06140	COG1136	(ABC) transporter
Ami3637_RS06155	COG0698	ribose 5-phosphate isomerase
Ami3637_RS06160	COG0009	L-threonylcarbamoyladenylate synthase
Ami3637_RS06170	COG0254	rRNA binding
Ami3637_RS06175	COG2807	transmembrane transport
Ami3637_RS06180	COG2890	protein-(glutamine-N5) methyltransferase activity
Ami3637_RS06185	COG3872	metal-dependent enzyme
Ami3637_RS06190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Ami3637_RS06205	COG1250	3-hydroxyacyl-CoA dehydrogenase
Ami3637_RS06210	COG0166	Belongs to the GPI family
Ami3637_RS06245	COG2801	Transposase and inactivated derivatives
Ami3637_RS06250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Ami3637_RS06280	COG0463	Glycosyl transferase, family 2
Ami3637_RS06325	COG0110	maltose O-acetyltransferase activity
Ami3637_RS06340	COG1216	Glycosyl transferase, family 2
Ami3637_RS06360	COG1088	dTDP-glucose 4,6-dehydratase activity
Ami3637_RS06370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ami3637_RS06375	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Ami3637_RS06375	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Ami3637_RS06380	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Ami3637_RS06385	COG0438	transferase activity, transferring glycosyl groups
Ami3637_RS06405	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Ami3637_RS06410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ami3637_RS06425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Ami3637_RS06430	COG1028	Short-chain dehydrogenase reductase Sdr
Ami3637_RS06445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Ami3637_RS06455	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Ami3637_RS06465	COG1086	Polysaccharide biosynthesis protein
Ami3637_RS06470	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Ami3637_RS06495	COG0728	peptidoglycan biosynthetic process
Ami3637_RS06500	COG3693	PFAM glycoside hydrolase, family 10
Ami3637_RS06525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Ami3637_RS06535	COG3693	PFAM glycoside hydrolase, family 10
Ami3637_RS06540	COG0038	chloride channel
Ami3637_RS06550	COG1122	ATPase activity
Ami3637_RS06575	COG3409	Peptidoglycan-binding domain 1 protein
Ami3637_RS06575	COG0793	Belongs to the peptidase S41A family
Ami3637_RS06590	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Ami3637_RS06595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Ami3637_RS06600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Ami3637_RS06615	COG1776	CheC inhibitor of MCP methylation
Ami3637_RS06620	COG1802	Transcriptional regulator
Ami3637_RS06625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Ami3637_RS06630	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Ami3637_RS06645	COG0446	pyridine nucleotide-disulphide oxidoreductase
Ami3637_RS06670	COG2059	Chromate
Ami3637_RS06705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Ami3637_RS06740	COG1522	sequence-specific DNA binding
Ami3637_RS06790	COG1136	(ABC) transporter
Ami3637_RS06790	COG0577	efflux transmembrane transporter activity
Ami3637_RS06815	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Ami3637_RS06830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Ami3637_RS06840	COG1114	Component of the transport system for branched-chain amino acids
Ami3637_RS06860	COG1882	Formate acetyltransferase
Ami3637_RS06875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Ami3637_RS06885	COG1802	Transcriptional regulator
Ami3637_RS06905	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Ami3637_RS06910	COG2986	histidine ammonia-lyase
Ami3637_RS06935	COG2211	Major facilitator Superfamily
Ami3637_RS06945	COG1012	belongs to the aldehyde dehydrogenase family
Ami3637_RS06980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Ami3637_RS07005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Ami3637_RS07010	COG0440	acetolactate synthase activity
Ami3637_RS07015	COG0028	Belongs to the TPP enzyme family
Ami3637_RS07020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Ami3637_RS07030	COG0066	3-isopropylmalate dehydratase activity
Ami3637_RS07035	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Ami3637_RS07040	COG0066	3-isopropylmalate dehydratase activity
Ami3637_RS07055	COG5001	Diguanylate cyclase
Ami3637_RS07060	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Ami3637_RS07065	COG0287	Prephenate dehydrogenase
Ami3637_RS07070	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Ami3637_RS07075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Ami3637_RS07080	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Ami3637_RS07090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Ami3637_RS07105	COG3152	Membrane
Ami3637_RS07115	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Ami3637_RS07120	COG0251	oxidation-reduction process
Ami3637_RS07125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Ami3637_RS07145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Ami3637_RS07160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Ami3637_RS07165	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
Ami3637_RS07200	COG5002	protein histidine kinase activity
Ami3637_RS07210	COG0745	RESPONSE REGULATOR receiver
Ami3637_RS07220	COG0840	transmembrane signaling receptor activity
Ami3637_RS07225	COG1404	Belongs to the peptidase S8 family
Ami3637_RS07230	COG1404	Belongs to the peptidase S8 family
Ami3637_RS07245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Ami3637_RS07250	COG1757	Na H antiporter
Ami3637_RS07270	COG0572	uridine kinase
Ami3637_RS07275	COG0739	heme binding
Ami3637_RS07295	COG0305	Participates in initiation and elongation during chromosome replication
Ami3637_RS07300	COG0359	binds to the 23S rRNA
Ami3637_RS07305	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Ami3637_RS07315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Ami3637_RS07325	COG0360	Binds together with S18 to 16S ribosomal RNA
Ami3637_RS07375	COG1606	tRNA processing
Ami3637_RS07385	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Ami3637_RS07390	COG0671	phosphoesterase, PA-phosphatase related
Ami3637_RS07400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Ami3637_RS07430	COG1131	(ABC) transporter
Ami3637_RS07435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Ami3637_RS07440	COG0180	Tryptophanyl-tRNA synthetase
Ami3637_RS07445	COG1191	sigma factor activity
Ami3637_RS07455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Ami3637_RS07460	COG0187	DNA topoisomerase II activity
Ami3637_RS07470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Ami3637_RS07475	COG0592	DNA-directed DNA polymerase activity
Ami3637_RS07485	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Ami3637_RS07500	COG0706	membrane insertase activity
Ami3637_RS07505	COG1847	R3H domain protein
Ami3637_RS07510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Ami3637_RS07515	COG0445	tRNA wobble uridine modification
Ami3637_RS07520	COG0357	Ribosomal RNA small subunit methyltransferase G
Ami3637_RS07530	COG1192	Involved in chromosome partitioning
Ami3637_RS07535	COG1475	DNA binding
Ami3637_RS07540	COG3326	Membrane
Ami3637_RS07545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ami3637_RS07550	COG1136	(ABC) transporter
Ami3637_RS07555	COG0577	efflux transmembrane transporter activity
Ami3637_RS07565	COG1725	Transcriptional regulator
Ami3637_RS07595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Ami3637_RS07625	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Ami3637_RS07655	COG1982	Orn Lys Arg decarboxylase major
Ami3637_RS07660	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Ami3637_RS07665	COG0010	Belongs to the arginase family
Ami3637_RS07685	COG1757	Na H antiporter
Ami3637_RS07690	COG3829	transcription factor binding
Ami3637_RS07695	COG0686	Belongs to the AlaDH PNT family
Ami3637_RS07705	COG3829	transcription factor binding
Ami3637_RS07710	COG3804	dihydrodipicolinate reductase
Ami3637_RS07720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Ami3637_RS07730	COG5012	cobalamin binding
Ami3637_RS07740	COG3457	Alanine racemase
Ami3637_RS07745	COG0840	transmembrane signaling receptor activity
Ami3637_RS07750	COG2827	Endonuclease containing a URI domain
Ami3637_RS07755	COG0028	Belongs to the TPP enzyme family
Ami3637_RS07760	COG0835	chemotaxis
Ami3637_RS07760	COG0784	Response regulator, receiver
Ami3637_RS07765	COG0315	cyclic pyranopterin monophosphate synthase activity
Ami3637_RS07805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Ami3637_RS07820	COG0438	transferase activity, transferring glycosyl groups
Ami3637_RS07825	COG0438	transferase activity, transferring glycosyl groups
Ami3637_RS07840	COG1773	rubredoxin
Ami3637_RS07845	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Ami3637_RS07875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Ami3637_RS07880	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Ami3637_RS07895	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Ami3637_RS07905	COG0745	RESPONSE REGULATOR receiver
Ami3637_RS07910	COG2205	protein histidine kinase activity
Ami3637_RS07930	COG1522	sequence-specific DNA binding
Ami3637_RS07945	COG1686	Belongs to the peptidase S11 family
Ami3637_RS07950	COG3457	Alanine racemase
Ami3637_RS07955	COG1126	abc transporter atp-binding protein
Ami3637_RS07960	COG0626	cystathionine gamma-synthase activity
Ami3637_RS07965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ami3637_RS07970	COG0765	amino acid transport
Ami3637_RS07980	COG3829	transcription factor binding
Ami3637_RS07985	COG0531	amino acid
Ami3637_RS07990	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Ami3637_RS08005	COG1361	Conserved repeat domain
Ami3637_RS08005	COG2911	Protein conserved in bacteria
Ami3637_RS08005	COG3266	domain, Protein
Ami3637_RS08010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Ami3637_RS08030	COG1288	antiporter activity
Ami3637_RS08090	COG1615	UPF0182 protein
Ami3637_RS08100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Ami3637_RS08150	COG0840	transmembrane signaling receptor activity
Ami3637_RS08155	COG2357	RelA SpoT domain protein
Ami3637_RS08160	COG0725	ABC transporter, periplasmic molybdate-binding protein
Ami3637_RS08165	COG4149	molybdate abc transporter
Ami3637_RS08170	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Ami3637_RS08170	COG3608	succinylglutamate desuccinylase aspartoacylase
Ami3637_RS08180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Ami3637_RS08185	COG0840	transmembrane signaling receptor activity
Ami3637_RS08190	COG0840	transmembrane signaling receptor activity
Ami3637_RS08195	COG0640	Transcriptional regulator
Ami3637_RS08200	COG2217	Heavy metal translocating P-type atpase
Ami3637_RS08210	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Ami3637_RS08215	COG0402	S-adenosylhomocysteine deaminase activity
Ami3637_RS08225	COG0583	DNA-binding transcription factor activity
Ami3637_RS08230	COG4656	Part of a membrane complex involved in electron transport
Ami3637_RS08240	COG4659	FMN binding
Ami3637_RS08245	COG4660	Part of a membrane complex involved in electron transport
Ami3637_RS08250	COG4657	Part of a membrane complex involved in electron transport
Ami3637_RS08255	COG1245	4Fe-4S binding domain
Ami3637_RS08255	COG2878	Part of a membrane complex involved in electron transport
Ami3637_RS08330	COG1131	(ABC) transporter
Ami3637_RS08350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Ami3637_RS08380	COG0019	diaminopimelate decarboxylase activity
Ami3637_RS08385	COG1115	amino acid carrier protein
Ami3637_RS08400	COG1752	Esterase of the alpha-beta hydrolase superfamily
Ami3637_RS08435	COG1122	ATPase activity
Ami3637_RS08450	COG2267	carboxylic ester hydrolase activity
Ami3637_RS08465	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Ami3637_RS08470	COG1752	Esterase of the alpha-beta hydrolase superfamily
Ami3637_RS08480	COG0573	inorganic phosphate transmembrane transporter activity
Ami3637_RS08485	COG0581	inorganic phosphate transmembrane transporter activity
Ami3637_RS08490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Ami3637_RS08500	COG0745	RESPONSE REGULATOR receiver
Ami3637_RS08515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Ami3637_RS08520	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Ami3637_RS08530	COG0183	Belongs to the thiolase family
Ami3637_RS08540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ami3637_RS08545	COG0765	amino acid transport
Ami3637_RS08550	COG1126	abc transporter atp-binding protein
Ami3637_RS08575	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Ami3637_RS08585	COG0281	malic enzyme
Ami3637_RS08590	COG5002	protein histidine kinase activity
Ami3637_RS08590	COG2205	protein histidine kinase activity
Ami3637_RS08590	COG0784	Response regulator, receiver
Ami3637_RS08600	COG1534	Rna-binding protein
Ami3637_RS08615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Ami3637_RS08620	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Ami3637_RS08625	COG0534	Mate efflux family protein
Ami3637_RS08635	COG0356	it plays a direct role in the translocation of protons across the membrane
Ami3637_RS08640	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Ami3637_RS08645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Ami3637_RS08650	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Ami3637_RS08655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Ami3637_RS08660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Ami3637_RS08665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Ami3637_RS08670	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Ami3637_RS08680	COG3706	GGDEF domain
Ami3637_RS08700	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Ami3637_RS08700	COG1918	ferrous iron import across plasma membrane
Ami3637_RS08705	COG1196	nuclear chromosome segregation
Ami3637_RS08705	COG0741	lytic transglycosylase activity
Ami3637_RS08705	COG0739	heme binding
Ami3637_RS08710	COG1760	l-serine dehydratase
Ami3637_RS08720	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Ami3637_RS08730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Ami3637_RS08750	COG1686	Belongs to the peptidase S11 family
Ami3637_RS08765	COG0840	transmembrane signaling receptor activity
Ami3637_RS08785	COG1380	Effector of murein hydrolase LrgA
Ami3637_RS08800	COG2186	Transcriptional regulator
Ami3637_RS08810	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Ami3637_RS08815	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Ami3637_RS08820	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Ami3637_RS08825	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Ami3637_RS08835	COG0138	bifunctional purine biosynthesis protein purh
Ami3637_RS08950	COG5002	protein histidine kinase activity
Ami3637_RS08960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ami3637_RS08970	COG1360	Flagellar Motor Protein
Ami3637_RS08975	COG1187	pseudouridine synthase activity
Ami3637_RS09005	COG4978	Transcriptional regulator
Ami3637_RS09005	COG0789	Transcriptional regulator
Ami3637_RS09010	COG1309	transcriptional regulator
Ami3637_RS09020	COG1566	PFAM secretion protein HlyD family protein
Ami3637_RS09025	COG2814	Major facilitator Superfamily
Ami3637_RS09030	COG3829	transcription factor binding
Ami3637_RS09040	COG4187	Peptidase family M20/M25/M40
Ami3637_RS09045	COG0833	amino acid
Ami3637_RS09060	COG1361	Conserved repeat domain
Ami3637_RS09085	COG2205	protein histidine kinase activity
Ami3637_RS09090	COG1136	(ABC) transporter
Ami3637_RS09090	COG0577	efflux transmembrane transporter activity
Ami3637_RS09100	COG0445	tRNA wobble uridine modification
Ami3637_RS09100	COG0445	tRNA wobble uridine modification
Ami3637_RS09115	COG2195	Cleaves the N-terminal amino acid of tripeptides
Ami3637_RS09120	COG2195	Cleaves the N-terminal amino acid of tripeptides
Ami3637_RS09130	COG0165	Argininosuccinate lyase
Ami3637_RS09145	COG2080	2 iron, 2 sulfur cluster binding
Ami3637_RS09145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Ami3637_RS09155	COG1607	acyl-coa hydrolase
Ami3637_RS09165	COG0604	alcohol dehydrogenase
Ami3637_RS09170	COG0604	alcohol dehydrogenase
Ami3637_RS09175	COG1509	lysine 2,3-aminomutase activity
Ami3637_RS09185	COG1193	negative regulation of DNA recombination
Ami3637_RS09190	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Ami3637_RS09195	COG5012	cobalamin binding
Ami3637_RS09200	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Ami3637_RS09210	COG0784	Response regulator, receiver
Ami3637_RS09210	COG0835	chemotaxis
Ami3637_RS09230	COG1388	LysM domain
Ami3637_RS09230	COG0860	N-Acetylmuramoyl-L-alanine amidase
Ami3637_RS09245	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Ami3637_RS09250	COG0527	aspartate kinase activity
Ami3637_RS09255	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Ami3637_RS09260	COG3901	Regulator of nitric oxide reductase transcription
Ami3637_RS09260	COG0348	domain, Protein
Ami3637_RS09265	COG4536	flavin adenine dinucleotide binding
Ami3637_RS09270	COG0653	protein targeting
Ami3637_RS09280	COG2183	response to ionizing radiation
Ami3637_RS09290	COG0546	phosphoglycolate phosphatase activity
Ami3637_RS09295	COG0438	transferase activity, transferring glycosyl groups
Ami3637_RS09300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Ami3637_RS09310	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Ami3637_RS09315	COG1028	Short-chain dehydrogenase reductase Sdr
Ami3637_RS09325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Ami3637_RS09340	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Ami3637_RS09345	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Ami3637_RS09400	COG0840	transmembrane signaling receptor activity
Ami3637_RS09405	COG2197	response regulator
Ami3637_RS09540	COG1222	aaa ATPase
Ami3637_RS09545	COG2197	response regulator
Ami3637_RS09580	COG4303	Ethanolamine ammonia lyase large subunit
Ami3637_RS09590	COG4816	utilization protein
Ami3637_RS09595	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Ami3637_RS09620	COG4869	propanediol catabolic process
Ami3637_RS09660	COG4820	ethanolamine utilization protein (EutJ)
Ami3637_RS09690	COG2234	aminopeptidase activity
Ami3637_RS09700	COG0318	PFAM AMP-dependent synthetase and ligase
Ami3637_RS09705	COG1022	Amp-dependent synthetase and ligase
Ami3637_RS09710	COG3457	Alanine racemase
Ami3637_RS09715	COG0697	spore germination
Ami3637_RS09720	COG0745	RESPONSE REGULATOR receiver
Ami3637_RS09725	COG0642	Histidine kinase
Ami3637_RS09730	COG1136	(ABC) transporter
Ami3637_RS09740	COG0745	RESPONSE REGULATOR receiver
Ami3637_RS09745	COG5002	protein histidine kinase activity
Ami3637_RS09755	COG1876	peptidase activity
Ami3637_RS09760	COG3279	Response regulator of the LytR AlgR family
Ami3637_RS09805	COG0789	Transcriptional regulator
Ami3637_RS09805	COG4978	Transcriptional regulator
Ami3637_RS09810	COG1811	Na channel or pump
Ami3637_RS09815	COG1592	Rubrerythrin
Ami3637_RS09815	COG1773	rubredoxin
Ami3637_RS09825	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Ami3637_RS09835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Ami3637_RS09840	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Ami3637_RS09850	COG1214	PFAM Peptidase M22, glycoprotease
Ami3637_RS09855	COG0456	acetyltransferase
Ami3637_RS09870	COG0488	(ABC) transporter
Ami3637_RS09875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ami3637_RS09880	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Ami3637_RS09900	COG1811	Na channel or pump
Ami3637_RS09905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Ami3637_RS09910	COG0459	protein refolding
Ami3637_RS09930	COG1115	amino acid carrier protein
Ami3637_RS09940	COG1876	peptidase activity
Ami3637_RS09945	COG0516	GMP reductase activity
Ami3637_RS09945	COG0517	IMP dehydrogenase activity
Ami3637_RS09980	COG2373	Large extracellular alpha-helical protein
Ami3637_RS10035	COG0596	Alpha beta hydrolase
Ami3637_RS10115	COG0833	amino acid
Ami3637_RS10120	COG0583	DNA-binding transcription factor activity
Ami3637_RS10125	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Ami3637_RS10135	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Ami3637_RS10165	COG2207	Transcriptional regulator
Ami3637_RS10165	COG3708	Transcriptional regulator
Ami3637_RS10190	COG0628	permease
Ami3637_RS10200	COG2002	toxin-antitoxin pair type II binding
Ami3637_RS10210	COG1733	regulation of RNA biosynthetic process
Ami3637_RS10215	COG1357	PFAM Pentapeptide repeats (8 copies)
Ami3637_RS10220	COG1937	Protein conserved in bacteria
Ami3637_RS10230	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Ami3637_RS10235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Ami3637_RS10240	COG0534	Mate efflux family protein
Ami3637_RS10245	COG0840	transmembrane signaling receptor activity
Ami3637_RS10255	COG0840	transmembrane signaling receptor activity
Ami3637_RS10260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Ami3637_RS10265	COG2011	ABC-type metal ion transport system permease component
Ami3637_RS10270	COG1464	Belongs to the NlpA lipoprotein family
Ami3637_RS10290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Ami3637_RS10295	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Ami3637_RS10300	COG0326	Molecular chaperone. Has ATPase activity
Ami3637_RS10335	COG0559	Belongs to the binding-protein-dependent transport system permease family
Ami3637_RS10360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Ami3637_RS10370	COG1053	succinate dehydrogenase
Ami3637_RS10380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Ami3637_RS10385	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Ami3637_RS10405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Ami3637_RS10405	COG0723	plastoquinol--plastocyanin reductase activity
Ami3637_RS10410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Ami3637_RS10440	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Ami3637_RS10455	COG1132	(ABC) transporter
Ami3637_RS10465	COG1268	BioY protein
Ami3637_RS10480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ami3637_RS10480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ami3637_RS10485	COG0513	Belongs to the DEAD box helicase family
Ami3637_RS10490	COG1595	DNA-templated transcription, initiation
Ami3637_RS10495	COG0154	amidase activity
Ami3637_RS10500	COG0840	transmembrane signaling receptor activity
Ami3637_RS10510	COG0463	Glycosyl transferase, family 2
Ami3637_RS10525	COG0084	hydrolase, TatD family'
Ami3637_RS10550	COG0488	(ABC) transporter
Ami3637_RS10555	COG0037	tRNA processing
Ami3637_RS10560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Ami3637_RS10565	COG2508	Transcriptional regulator
Ami3637_RS10565	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
Ami3637_RS10585	COG4770	biotin carboxylase activity
Ami3637_RS10595	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Ami3637_RS10600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Ami3637_RS10605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Ami3637_RS10615	COG0017	Asparaginyl-tRNA synthetase
Ami3637_RS10620	COG0252	asparaginase activity
Ami3637_RS10630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Ami3637_RS10635	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Ami3637_RS10640	COG0531	amino acid
Ami3637_RS10645	COG0745	RESPONSE REGULATOR receiver
Ami3637_RS10650	COG3850	Histidine kinase
Ami3637_RS10650	COG5002	protein histidine kinase activity
Ami3637_RS10660	COG4956	integral membrane protein (PIN domain superfamily)
Ami3637_RS10665	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Ami3637_RS10665	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Ami3637_RS10670	COG0442	prolyl-tRNA aminoacylation
Ami3637_RS10675	COG2860	membrane
Ami3637_RS10685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Ami3637_RS10690	COG0739	heme binding
Ami3637_RS10695	COG0215	cysteine-tRNA ligase activity
Ami3637_RS10700	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
Ami3637_RS10710	COG1234	tRNA 3'-trailer cleavage
Ami3637_RS10720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Ami3637_RS10740	COG2030	dehydratase
Ami3637_RS10750	COG3243	poly(R)-hydroxyalkanoic acid synthase
Ami3637_RS10760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Ami3637_RS10800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Ami3637_RS10805	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Ami3637_RS10810	COG0250	Participates in transcription elongation, termination and antitermination
Ami3637_RS10815	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Ami3637_RS10820	COG0081	regulation of translation
Ami3637_RS10830	COG0222	ribosome binding
Ami3637_RS10845	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Ami3637_RS10850	COG0049	tRNA binding
Ami3637_RS10860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Ami3637_RS10865	COG0622	Phosphoesterase
Ami3637_RS10880	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Ami3637_RS10890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Ami3637_RS10895	COG0210	DNA helicase
Ami3637_RS10900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Ami3637_RS10930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Ami3637_RS10935	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Ami3637_RS10940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Ami3637_RS10955	COG1013	pyruvate-flavodoxin oxidoreductase activity
Ami3637_RS10955	COG0674	pyruvate-flavodoxin oxidoreductase activity
Ami3637_RS10955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Ami3637_RS10955	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Ami3637_RS10960	COG1131	(ABC) transporter
Ami3637_RS10985	COG0372	Belongs to the citrate synthase family
Ami3637_RS10990	COG0556	nucleotide-excision repair
Ami3637_RS11000	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Ami3637_RS11020	COG0191	fructose-bisphosphate aldolase activity
Ami3637_RS11045	COG0681	Belongs to the peptidase S26 family
Ami3637_RS11050	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Ami3637_RS11070	COG4974	Belongs to the 'phage' integrase family
Ami3637_RS11095	COG2359	stage V sporulation protein S
Ami3637_RS11115	COG1388	LysM domain
Ami3637_RS11115	COG3584	3D domain protein
Ami3637_RS11195	COG5484	DNA packaging
Ami3637_RS11290	COG3299	homolog of phage Mu protein gp47
Ami3637_RS11375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Ami3637_RS11385	COG2247	cell wall binding repeat
Ami3637_RS11385	COG0860	N-Acetylmuramoyl-L-alanine amidase
Ami3637_RS11390	COG1846	Transcriptional regulator
Ami3637_RS11450	COG0697	spore germination
Ami3637_RS11455	COG1733	regulation of RNA biosynthetic process
Ami3637_RS11490	COG1882	Formate acetyltransferase
Ami3637_RS11510	COG0656	L-ascorbic acid biosynthetic process
Ami3637_RS11515	COG2207	Transcriptional regulator
Ami3637_RS11515	COG1917	Cupin 2, conserved barrel domain protein
Ami3637_RS11520	COG5012	cobalamin binding
Ami3637_RS11545	COG5012	cobalamin binding
Ami3637_RS11570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Ami3637_RS11590	COG0523	cobalamin synthesis protein
Ami3637_RS11615	COG3409	Peptidoglycan-binding domain 1 protein
Ami3637_RS11615	COG3773	Cell wall hydrolase
Ami3637_RS11630	COG3853	Toxic anion resistance protein (TelA)
Ami3637_RS11640	COG3706	GGDEF domain
Ami3637_RS11660	COG1566	PFAM secretion protein HlyD family protein
Ami3637_RS11690	COG4191	Histidine kinase
Ami3637_RS11695	COG2204	response regulator
Ami3637_RS11700	COG0531	amino acid
Ami3637_RS11705	COG0531	amino acid
Ami3637_RS11715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Ami3637_RS11720	COG1696	Membrane protein involved in D-alanine export
Ami3637_RS11730	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
Ami3637_RS11750	COG1129	ABC transporter
Ami3637_RS11765	COG1063	alcohol dehydrogenase
Ami3637_RS11770	COG1070	Carbohydrate kinase
Ami3637_RS11785	COG1129	ABC transporter
Ami3637_RS11790	COG1172	Belongs to the binding-protein-dependent transport system permease family
Ami3637_RS11800	COG1045	serine acetyltransferase
Ami3637_RS11820	COG0504	CTP synthase activity
Ami3637_RS11840	COG1609	Transcriptional regulator
Ami3637_RS11870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ami3637_RS11880	COG1136	(ABC) transporter
Ami3637_RS11885	COG1136	(ABC) transporter
Ami3637_RS11885	COG0577	efflux transmembrane transporter activity
Ami3637_RS11890	COG0577	efflux transmembrane transporter activity
Ami3637_RS11930	COG0116	Belongs to the methyltransferase superfamily
Ami3637_RS11935	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Ami3637_RS11940	COG0505	Belongs to the CarA family
Ami3637_RS11945	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Ami3637_RS11950	COG3279	Response regulator of the LytR AlgR family
Ami3637_RS11980	COG1802	Transcriptional regulator
Ami3637_RS11985	COG0628	permease
Ami3637_RS12025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Ami3637_RS12035	COG0470	DNA polymerase III
Ami3637_RS12045	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Ami3637_RS12065	COG2002	toxin-antitoxin pair type II binding
Ami3637_RS12075	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Ami3637_RS12080	COG0012	GTP binding
Ami3637_RS12085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Ami3637_RS12090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Ami3637_RS12105	COG2001	Belongs to the MraZ family
Ami3637_RS12120	COG0768	penicillin binding
Ami3637_RS12130	COG0768	penicillin binding
Ami3637_RS12135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Ami3637_RS12140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Ami3637_RS12145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Ami3637_RS12150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Ami3637_RS12160	COG0772	Belongs to the SEDS family
Ami3637_RS12165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Ami3637_RS12170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Ami3637_RS12190	COG3856	small basic protein
Ami3637_RS12195	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Ami3637_RS12200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Ami3637_RS12205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Ami3637_RS12210	COG0072	phenylalanine-tRNA ligase activity
Ami3637_RS12210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ami3637_RS12215	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Ami3637_RS12230	COG0018	arginyl-trna synthetase
Ami3637_RS12305	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Ami3637_RS12325	COG5377	YqaJ viral recombinase family
Ami3637_RS12435	COG1690	Belongs to the RtcB family
Ami3637_RS12440	COG3541	Predicted nucleotidyltransferase
Ami3637_RS12445	COG0242	peptide deformylase activity
Ami3637_RS12450	COG0450	alkyl hydroperoxide reductase
Ami3637_RS12485	COG5001	Diguanylate cyclase
Ami3637_RS12495	COG0840	transmembrane signaling receptor activity
Ami3637_RS12550	COG0488	(ABC) transporter
Ami3637_RS12565	COG0833	amino acid
Ami3637_RS12570	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Ami3637_RS12585	COG1288	antiporter activity
Ami3637_RS12600	COG0205	6-phosphofructokinase activity
Ami3637_RS12610	COG0140	phosphoribosyl-ATP diphosphatase activity
Ami3637_RS12610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Ami3637_RS12615	COG0107	imidazoleglycerol-phosphate synthase activity
Ami3637_RS12620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Ami3637_RS12625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Ami3637_RS12630	COG0131	Imidazoleglycerol-phosphate dehydratase
Ami3637_RS12635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Ami3637_RS12640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Ami3637_RS12645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Ami3637_RS12650	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Ami3637_RS12660	COG1802	Transcriptional regulator
Ami3637_RS12665	COG0473	3-isopropylmalate dehydrogenase activity
Ami3637_RS12670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Ami3637_RS12675	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Ami3637_RS12690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ami3637_RS12695	COG1309	transcriptional regulator
Ami3637_RS12700	COG0653	protein targeting
Ami3637_RS12705	COG0460	homoserine dehydrogenase
Ami3637_RS12715	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Ami3637_RS12720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Ami3637_RS12730	COG0149	triose-phosphate isomerase activity
Ami3637_RS12735	COG0148	phosphopyruvate hydratase activity
Ami3637_RS12740	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Ami3637_RS12775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Ami3637_RS12795	COG0557	exoribonuclease II activity
Ami3637_RS12800	COG0517	IMP dehydrogenase activity
Ami3637_RS12805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Ami3637_RS12810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Ami3637_RS12815	COG0475	glutathione-regulated potassium exporter activity
Ami3637_RS12815	COG0569	domain protein
Ami3637_RS12825	COG0561	phosphatase activity
Ami3637_RS12835	COG0792	nuclease activity
Ami3637_RS12845	COG0758	DNA mediated transformation
Ami3637_RS12855	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Ami3637_RS12860	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Ami3637_RS12865	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
Ami3637_RS12875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Ami3637_RS12880	COG1739	Uncharacterized protein family UPF0029
Ami3637_RS13025	COG1435	thymidine kinase activity
Ami3637_RS13030	COG1242	4 iron, 4 sulfur cluster binding
Ami3637_RS13040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Ami3637_RS13045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Ami3637_RS13060	COG2738	Putative neutral zinc metallopeptidase
Ami3637_RS13065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Ami3637_RS13065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Ami3637_RS13075	COG2815	serine threonine protein kinase
Ami3637_RS13075	COG0515	serine threonine protein kinase
Ami3637_RS13080	COG2815	serine threonine protein kinase
Ami3637_RS13080	COG0515	serine threonine protein kinase
Ami3637_RS13085	COG1162	GTPase activity
Ami3637_RS13090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Ami3637_RS13100	COG0488	(ABC) transporter
Ami3637_RS13175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Ami3637_RS13180	COG2081	HI0933 family
Ami3637_RS13190	COG1982	Orn Lys Arg decarboxylase major
Ami3637_RS13200	COG1131	(ABC) transporter
Ami3637_RS13205	COG1725	Transcriptional regulator
Ami3637_RS13220	COG0616	signal peptide processing
Ami3637_RS13225	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Ami3637_RS13230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Ami3637_RS13235	COG0228	four-way junction DNA binding
Ami3637_RS13240	COG1837	Belongs to the UPF0109 family
Ami3637_RS13245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Ami3637_RS13250	COG0336	Belongs to the RNA methyltransferase TrmD family
Ami3637_RS13260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Ami3637_RS13265	COG1799	cell septum assembly
Ami3637_RS13275	COG3599	regulation of cell shape
Ami3637_RS13280	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Ami3637_RS13285	COG0564	pseudouridine synthase activity
Ami3637_RS13305	COG1561	YicC-like family, N-terminal region
Ami3637_RS13310	COG0194	GDP metabolic process
Ami3637_RS13315	COG1758	RNA polymerase activity
Ami3637_RS13325	COG0052	Belongs to the universal ribosomal protein uS2 family
Ami3637_RS13330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Ami3637_RS13340	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Ami3637_RS13345	COG0528	UMP kinase activity
Ami3637_RS13350	COG0233	cytoplasmic translational termination
Ami3637_RS13355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Ami3637_RS13360	COG0575	Belongs to the CDS family
Ami3637_RS13365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Ami3637_RS13370	COG0750	zinc metalloprotease
Ami3637_RS13375	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Ami3637_RS13390	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Ami3637_RS13400	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Ami3637_RS13410	COG0779	Required for maturation of 30S ribosomal subunits
Ami3637_RS13415	COG0195	Participates in both transcription termination and antitermination
Ami3637_RS13430	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Ami3637_RS13435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Ami3637_RS13440	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Ami3637_RS13450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Ami3637_RS13455	COG0196	riboflavin kinase activity
Ami3637_RS13465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Ami3637_RS13475	COG0004	ammonium transporteR
Ami3637_RS13480	COG2197	response regulator
Ami3637_RS13485	COG0004	ammonium transporteR
Ami3637_RS13500	COG1368	sulfuric ester hydrolase activity
Ami3637_RS13515	COG1454	alcohol dehydrogenase
Ami3637_RS13535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Ami3637_RS13535	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Ami3637_RS13575	COG1794	racemase activity, acting on amino acids and derivatives
Ami3637_RS13580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Ami3637_RS13585	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Ami3637_RS13600	COG1181	Belongs to the D-alanine--D-alanine ligase family
Ami3637_RS13615	COG0833	amino acid
Ami3637_RS13630	COG1115	amino acid carrier protein
Ami3637_RS13635	COG4191	Histidine kinase
Ami3637_RS13645	COG0833	amino acid
Ami3637_RS13695	COG0860	N-Acetylmuramoyl-L-alanine amidase
Ami3637_RS13705	COG2431	L-lysine efflux transmembrane transporter activity
Ami3637_RS13710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Ami3637_RS13720	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Ami3637_RS13725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Ami3637_RS13730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Ami3637_RS13745	COG1191	sigma factor activity
Ami3637_RS13770	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Ami3637_RS13780	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Ami3637_RS13785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Ami3637_RS13800	COG0544	peptidyl-prolyl cis-trans isomerase activity
Ami3637_RS13805	COG1873	PFAM PRC-barrel domain
Ami3637_RS13810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Ami3637_RS13815	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Ami3637_RS13840	COG0531	amino acid
Ami3637_RS13845	COG2205	protein histidine kinase activity
Ami3637_RS13855	COG2204	response regulator
Ami3637_RS13865	COG1136	(ABC) transporter
Ami3637_RS13880	COG2199	diguanylate cyclase activity
Ami3637_RS13900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Ami3637_RS13920	COG2003	Belongs to the UPF0758 family
Ami3637_RS13925	COG1077	Cell shape determining protein MreB Mrl
Ami3637_RS13945	COG2894	cell division
Ami3637_RS13950	COG0772	Belongs to the SEDS family
Ami3637_RS13955	COG1418	mRNA catabolic process
Ami3637_RS13960	COG0534	Mate efflux family protein
Ami3637_RS13965	COG1104	cysteine desulfurase activity
Ami3637_RS13970	COG0301	tRNA thio-modification
Ami3637_RS13980	COG2172	sigma factor antagonist activity
Ami3637_RS13985	COG1191	sigma factor activity
Ami3637_RS13990	COG1960	acyl-CoA dehydrogenase activity
Ami3637_RS13995	COG2086	electron transfer activity
Ami3637_RS14000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Ami3637_RS14020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Ami3637_RS14065	COG0658	competence protein
Ami3637_RS14065	COG2333	competence protein COMEC
Ami3637_RS14120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Ami3637_RS14125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Ami3637_RS14145	COG0574	Belongs to the PEP-utilizing enzyme family
Ami3637_RS14145	COG3848	Pyruvate phosphate dikinase
Ami3637_RS14150	COG1309	transcriptional regulator
Ami3637_RS14155	COG1024	Enoyl-CoA hydratase
Ami3637_RS14175	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Ami3637_RS14195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Ami3637_RS14215	COG2205	protein histidine kinase activity
Ami3637_RS14220	COG0745	RESPONSE REGULATOR receiver
Ami3637_RS14230	COG0569	domain protein
Ami3637_RS14240	COG1686	Belongs to the peptidase S11 family
Ami3637_RS14250	COG1489	DNA binding
Ami3637_RS14295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Ami3637_RS14310	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Ami3637_RS14320	COG0674	pyruvate-flavodoxin oxidoreductase activity
Ami3637_RS14325	COG1013	pyruvate-flavodoxin oxidoreductase activity
Ami3637_RS14345	COG0583	DNA-binding transcription factor activity
Ami3637_RS14380	COG0242	peptide deformylase activity
Ami3637_RS14395	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Ami3637_RS14405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Ami3637_RS14410	COG0352	thiamine-phosphate diphosphorylase activity
Ami3637_RS14410	COG0351	phosphomethylpyrimidine kinase
Ami3637_RS14415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Ami3637_RS14430	COG0813	purine-nucleoside phosphorylase activity
Ami3637_RS14440	COG0318	PFAM AMP-dependent synthetase and ligase
Ami3637_RS14460	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Ami3637_RS14465	COG1151	hydroxylamine reductase activity
Ami3637_RS14480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Ami3637_RS14490	COG3706	GGDEF domain
Ami3637_RS14500	COG4475	Protein of unknown function (DUF436)
Ami3637_RS14510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Ami3637_RS14525	COG4555	ABC transporter
Ami3637_RS14545	COG0789	Transcriptional regulator
Ami3637_RS14545	COG4978	Transcriptional regulator
Ami3637_RS14550	COG1720	tRNA m6t6A37 methyltransferase activity
Ami3637_RS14560	COG3546	catalase activity
Ami3637_RS14570	COG1321	iron dependent repressor
Ami3637_RS14580	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Ami3637_RS14600	COG0840	transmembrane signaling receptor activity
Ami3637_RS14605	COG0574	Belongs to the PEP-utilizing enzyme family
Ami3637_RS14605	COG3848	Pyruvate phosphate dikinase
Ami3637_RS14625	COG1476	TRANSCRIPTIONal
Ami3637_RS14635	COG0531	amino acid
Ami3637_RS14650	COG1141	Ferredoxin
Ami3637_RS14705	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
Ami3637_RS14790	COG2508	Transcriptional regulator
Ami3637_RS14800	COG0436	Aminotransferase
Ami3637_RS14805	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
Ami3637_RS14805	COG2508	Transcriptional regulator
Ami3637_RS14810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Ami3637_RS14865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Ami3637_RS14900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Ami3637_RS14900	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Ami3637_RS14945	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
Ami3637_RS14950	COG0519	Catalyzes the synthesis of GMP from XMP
Ami3637_RS14965	COG3153	acetyltransferase
Ami3637_RS14980	COG1408	metallophosphoesterase
Ami3637_RS15030	COG0519	Catalyzes the synthesis of GMP from XMP
Ami3637_RS15065	COG1247	-acetyltransferase
Ami3637_RS15090	COG0475	glutathione-regulated potassium exporter activity
Ami3637_RS15120	COG0531	amino acid
Ami3637_RS15125	COG1686	Belongs to the peptidase S11 family
Ami3637_RS15130	COG1595	DNA-templated transcription, initiation
Ami3637_RS15145	COG2076	Multidrug Resistance protein
Ami3637_RS15165	COG1175	transmembrane transport
Ami3637_RS15170	COG1175	transmembrane transport
Ami3637_RS15175	COG1175	transmembrane transport
Ami3637_RS15200	COG3842	ATPase activity
Ami3637_RS15230	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Ami3637_RS15255	COG1177	transmembrane transport
Ami3637_RS15260	COG3842	ATPase activity
Ami3637_RS15270	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Ami3637_RS15275	COG1733	regulation of RNA biosynthetic process
Ami3637_RS15285	COG2878	Part of a membrane complex involved in electron transport
Ami3637_RS15295	COG2205	protein histidine kinase activity
Ami3637_RS15295	COG2770	Histidine kinase
Ami3637_RS15300	COG0745	RESPONSE REGULATOR receiver
Ami3637_RS15315	COG0348	domain, Protein
Ami3637_RS15330	COG0583	DNA-binding transcription factor activity
Ami3637_RS15340	COG0726	polysaccharide deacetylase
Ami3637_RS15345	COG0456	acetyltransferase
Ami3637_RS15350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Ami3637_RS15385	COG0420	3'-5' exonuclease activity
Ami3637_RS15390	COG0419	ATPase involved in DNA repair
Ami3637_RS15400	COG1404	Belongs to the peptidase S8 family
Ami3637_RS15445	COG2184	nucleotidyltransferase activity
Ami3637_RS15455	COG1362	aminopeptidase activity
Ami3637_RS15460	COG0006	proline dipeptidase activity
Ami3637_RS15485	COG0741	lytic transglycosylase activity
Ami3637_RS15505	COG1132	(ABC) transporter
Ami3637_RS15545	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Ami3637_RS15560	COG0840	transmembrane signaling receptor activity
Ami3637_RS15570	COG2957	Belongs to the agmatine deiminase family
Ami3637_RS15575	COG0833	amino acid
Ami3637_RS15580	COG4191	Histidine kinase
Ami3637_RS15585	COG2204	response regulator
Ami3637_RS15595	COG0840	transmembrane signaling receptor activity
Ami3637_RS15610	COG0534	Mate efflux family protein
Ami3637_RS15640	COG4974	Belongs to the 'phage' integrase family
Ami3637_RS15685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Ami3637_RS15710	COG3706	GGDEF domain
Ami3637_RS15715	COG3706	GGDEF domain
Ami3637_RS15725	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Ami3637_RS15765	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Ami3637_RS15785	COG1373	ATPase (AAA superfamily
Ami3637_RS15800	COG1696	Membrane protein involved in D-alanine export
Ami3637_RS15820	COG0612	Peptidase, M16
Ami3637_RS15840	COG1797	cobyrinic acid a,c-diamide synthase activity
Ami3637_RS15845	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Ami3637_RS15865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Ami3637_RS15870	COG1492	cobalamin metabolic process
Ami3637_RS15895	COG0306	phosphate transporter
Ami3637_RS15900	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Ami3637_RS15905	COG0358	DNA primase activity
Ami3637_RS15915	COG0358	DNA primase activity
Ami3637_RS15920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ami3637_RS15925	COG2384	SAM-dependent methyltransferase
Ami3637_RS15945	COG0534	Mate efflux family protein
Ami3637_RS15960	COG0217	transcriptional regulatory protein
Ami3637_RS15975	COG2116	formate transmembrane transporter activity
Ami3637_RS15990	COG3191	aminopeptidase activity
Ami3637_RS16000	COG1253	flavin adenine dinucleotide binding
Ami3637_RS16005	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Ami3637_RS16010	COG1595	DNA-templated transcription, initiation
Ami3637_RS16020	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Ami3637_RS16020	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Ami3637_RS16025	COG0237	dephospho-CoA kinase activity
Ami3637_RS16045	COG1862	Preprotein translocase
Ami3637_RS16055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Ami3637_RS16055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Ami3637_RS16060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Ami3637_RS16065	COG1490	D-aminoacyl-tRNA deacylase activity
Ami3637_RS16070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Ami3637_RS16075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ami3637_RS16080	COG0124	histidyl-tRNA synthetase
Ami3637_RS16085	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Ami3637_RS16095	COG1713	HD superfamily hydrolase involved in NAD metabolism
Ami3637_RS16100	COG0799	negative regulation of ribosome biogenesis
Ami3637_RS16105	COG0495	leucyl-tRNA aminoacylation
Ami3637_RS16110	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Ami3637_RS16115	COG3679	Belongs to the UPF0342 family
Ami3637_RS16120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Ami3637_RS16125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Ami3637_RS16130	COG4122	O-methyltransferase activity
Ami3637_RS16140	COG1253	flavin adenine dinucleotide binding
Ami3637_RS16150	COG3854	ATPases associated with a variety of cellular activities
Ami3637_RS16170	COG0667	Aldo Keto reductase
Ami3637_RS16180	COG4472	Bacterial protein of unknown function (DUF965)
Ami3637_RS16200	COG0789	Transcriptional regulator
Ami3637_RS16210	COG0667	Aldo Keto reductase
Ami3637_RS16225	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Ami3637_RS16245	COG1592	Rubrerythrin
Ami3637_RS16250	COG0392	lysyltransferase activity
Ami3637_RS16250	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Ami3637_RS16255	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Ami3637_RS16255	COG0392	lysyltransferase activity
Ami3637_RS16260	COG0392	lysyltransferase activity
Ami3637_RS16260	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Ami3637_RS16285	COG0348	domain, Protein
Ami3637_RS16285	COG3901	Regulator of nitric oxide reductase transcription
Ami3637_RS16290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Ami3637_RS16310	COG1388	LysM domain
Ami3637_RS16315	COG0346	lactoylglutathione lyase activity
Ami3637_RS16320	COG0398	Pfam SNARE associated Golgi protein
Ami3637_RS16325	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Ami3637_RS16335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Ami3637_RS16340	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Ami3637_RS16345	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Ami3637_RS16350	COG0436	Aminotransferase
Ami3637_RS16375	COG1570	exodeoxyribonuclease VII activity
Ami3637_RS16380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Ami3637_RS16385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Ami3637_RS16430	COG4224	UPF0291 protein
Ami3637_RS16435	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Ami3637_RS16440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Ami3637_RS16450	COG0750	zinc metalloprotease
Ami3637_RS16460	COG1596	polysaccharide export
Ami3637_RS16460	COG1555	photosystem II stabilization
Ami3637_RS16470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ami3637_RS16490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Ami3637_RS16495	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Ami3637_RS16500	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Ami3637_RS16505	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Ami3637_RS16515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Ami3637_RS16520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Ami3637_RS16595	COG1652	LysM domain
Ami3637_RS16670	COG0582	viral genome integration into host DNA
Ami3637_RS16675	COG4974	Belongs to the 'phage' integrase family
Ami3637_RS16750	COG1192	Involved in chromosome partitioning
Ami3637_RS16815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Ami3637_RS16820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Ami3637_RS16825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Ami3637_RS16830	COG1323	Belongs to the UPF0348 family
Ami3637_RS16845	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Ami3637_RS16850	COG0742	ribosomal rna small subunit methyltransferase
Ami3637_RS16860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Ami3637_RS16870	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Ami3637_RS16875	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Ami3637_RS16900	COG0583	DNA-binding transcription factor activity
Ami3637_RS16905	COG2855	membrane
Ami3637_RS16915	COG0840	transmembrane signaling receptor activity
Ami3637_RS16920	COG0840	transmembrane signaling receptor activity
Ami3637_RS16925	COG3290	protein histidine kinase activity
Ami3637_RS16925	COG0840	transmembrane signaling receptor activity
Ami3637_RS16930	COG1309	transcriptional regulator
Ami3637_RS16935	COG1194	a g-specific adenine glycosylase
Ami3637_RS16955	COG0521	Mo-molybdopterin cofactor biosynthetic process
Ami3637_RS16965	COG3706	GGDEF domain
Ami3637_RS17000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Ami3637_RS17015	COG1842	Phage shock protein A