locus-tag	class	description
AA2016_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AA2016_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA2016_RS00040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA2016_RS00050	COG0735	belongs to the Fur family
AA2016_RS00055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AA2016_RS00065	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AA2016_RS00070	COG3300	MHYT domain
AA2016_RS00070	COG5001	Diguanylate cyclase
AA2016_RS00075	COG2813	Specifically methylates the guanine in position
AA2016_RS00085	COG1185	polyribonucleotide nucleotidyltransferase activity
AA2016_RS00090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AA2016_RS00095	COG0598	Magnesium transport protein CorA
AA2016_RS00100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AA2016_RS00105	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AA2016_RS00110	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AA2016_RS00125	COG0779	Required for maturation of 30S ribosomal subunits
AA2016_RS00160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AA2016_RS00165	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AA2016_RS00170	COG1396	sequence-specific DNA binding
AA2016_RS00175	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AA2016_RS00180	COG1253	flavin adenine dinucleotide binding
AA2016_RS00185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AA2016_RS00190	COG1702	phosphate starvation-inducible protein PhoH
AA2016_RS00195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA2016_RS00215	COG1214	PFAM Peptidase M22, glycoprotease
AA2016_RS00220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AA2016_RS00260	COG0481	GTPase activity
AA2016_RS00280	COG3220	belongs to the UPF0276 family
AA2016_RS00320	COG0671	phosphoesterase, PA-phosphatase related
AA2016_RS00330	COG0659	secondary active sulfate transmembrane transporter activity
AA2016_RS00335	COG0443	Heat shock 70 kDa protein
AA2016_RS00350	COG2358	TRAP transporter, solute receptor (TAXI family
AA2016_RS00370	COG3795	YCII-related domain
AA2016_RS00380	COG0640	Transcriptional regulator
AA2016_RS00415	COG0842	Transport permease protein
AA2016_RS00420	COG1131	(ABC) transporter
AA2016_RS00435	COG2954	triphosphatase activity
AA2016_RS00455	COG1420	regulation of RNA biosynthetic process
AA2016_RS00460	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AA2016_RS00470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AA2016_RS00475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA2016_RS00495	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AA2016_RS00500	COG0792	nuclease activity
AA2016_RS00510	COG1254	Belongs to the acylphosphatase family
AA2016_RS00515	COG2124	cytochrome p450
AA2016_RS00545	COG0745	RESPONSE REGULATOR receiver
AA2016_RS00550	COG2205	protein histidine kinase activity
AA2016_RS00555	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AA2016_RS00560	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AA2016_RS00565	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AA2016_RS00580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AA2016_RS00590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA2016_RS00595	COG2226	methyltransferase
AA2016_RS00600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AA2016_RS00605	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AA2016_RS00625	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AA2016_RS00640	COG1079	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS00650	COG3845	ABC transporter
AA2016_RS00655	COG2900	Belongs to the SlyX family
AA2016_RS00665	COG1744	ABC transporter substrate-binding protein PnrA-like
AA2016_RS00670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA2016_RS00725	COG1477	protein flavinylation
AA2016_RS00740	COG0577	efflux transmembrane transporter activity
AA2016_RS00740	COG1136	(ABC) transporter
AA2016_RS00765	COG1278	Cold shock
AA2016_RS00800	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_RS00830	COG0251	oxidation-reduction process
AA2016_RS00845	COG0662	Cupin 2, conserved barrel domain protein
AA2016_RS00855	COG0848	biopolymer transport protein
AA2016_RS00905	COG1082	Xylose isomerase domain protein TIM barrel
AA2016_RS00910	COG4607	ABC-type enterochelin transport system periplasmic component
AA2016_RS00915	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA2016_RS00920	COG4605	iron ion homeostasis
AA2016_RS00925	COG4604	ABC transporter, ATP-binding protein
AA2016_RS00930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AA2016_RS00935	COG4638	Rieske (2fe-2S)
AA2016_RS00970	COG4771	TonB-dependent receptor
AA2016_RS00975	COG4178	(ABC) transporter
AA2016_RS00995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AA2016_RS01000	COG0459	protein refolding
AA2016_RS01015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AA2016_RS01035	COG0395	ABC-type sugar transport system, permease component
AA2016_RS01040	COG1175	transmembrane transport
AA2016_RS01055	COG1765	OsmC-like protein
AA2016_RS01060	COG2766	serine protein kinase
AA2016_RS01065	COG2718	Belongs to the UPF0229 family
AA2016_RS01070	COG2719	SpoVR family
AA2016_RS01075	COG3142	Participates in the control of copper homeostasis
AA2016_RS01080	COG1940	carbohydrate kinase activity
AA2016_RS01090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_RS01095	COG1446	asparaginase
AA2016_RS01105	COG0765	amino acid transport
AA2016_RS01110	COG0765	amino acid transport
AA2016_RS01145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AA2016_RS01180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA2016_RS01185	COG1280	lysine exporter protein (LysE YggA)
AA2016_RS01190	COG1957	nucleoside hydrolase
AA2016_RS01205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA2016_RS01210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AA2016_RS01215	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AA2016_RS01220	COG1137	ATPase activity
AA2016_RS01225	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AA2016_RS01235	COG0616	signal peptide processing
AA2016_RS01240	COG0776	regulation of translation
AA2016_RS01250	COG2423	ornithine cyclodeaminase activity
AA2016_RS01265	COG2378	regulation of single-species biofilm formation
AA2016_RS01270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AA2016_RS01270	COG0116	Belongs to the methyltransferase superfamily
AA2016_RS01275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA2016_RS01280	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AA2016_RS01290	COG5002	protein histidine kinase activity
AA2016_RS01290	COG0784	Response regulator, receiver
AA2016_RS01290	COG2205	protein histidine kinase activity
AA2016_RS01315	COG1252	NADH dehydrogenase
AA2016_RS01320	COG2860	membrane
AA2016_RS01325	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AA2016_RS01340	COG0175	sulfate reduction
AA2016_RS01345	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA2016_RS01355	COG1648	precorrin-2 dehydrogenase activity
AA2016_RS01355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA2016_RS01365	COG4651	solute:proton antiporter activity
AA2016_RS01365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA2016_RS01390	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AA2016_RS01415	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA2016_RS01420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA2016_RS01425	COG1942	4-Oxalocrotonate Tautomerase
AA2016_RS01440	COG1733	regulation of RNA biosynthetic process
AA2016_RS01450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA2016_RS01450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA2016_RS01455	COG1280	lysine exporter protein (LysE YggA)
AA2016_RS01465	COG0667	Aldo Keto reductase
AA2016_RS01470	COG0673	inositol 2-dehydrogenase activity
AA2016_RS01485	COG0395	ABC-type sugar transport system, permease component
AA2016_RS01490	COG1175	transmembrane transport
AA2016_RS01505	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AA2016_RS01515	COG0803	Belongs to the bacterial solute-binding protein 9 family
AA2016_RS01520	COG1121	(ABC) transporter
AA2016_RS01525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AA2016_RS01530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AA2016_RS01535	COG3842	ATPase activity
AA2016_RS01540	COG0366	Alpha amylase catalytic
AA2016_RS01545	COG0395	ABC-type sugar transport system, permease component
AA2016_RS01550	COG1175	transmembrane transport
AA2016_RS01555	COG1653	transport
AA2016_RS01560	COG1609	Transcriptional regulator
AA2016_RS01565	COG1802	Transcriptional regulator
AA2016_RS01570	COG2272	Belongs to the type-B carboxylesterase lipase family
AA2016_RS01575	COG0543	2 iron, 2 sulfur cluster binding
AA2016_RS01575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AA2016_RS01590	COG1595	DNA-templated transcription, initiation
AA2016_RS01600	COG1404	Belongs to the peptidase S8 family
AA2016_RS01625	COG3811	Belongs to the UPF0386 family
AA2016_RS01645	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_RS01680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_RS01685	COG0154	amidase activity
AA2016_RS01695	COG0747	negative chemotaxis
AA2016_RS01700	COG0601	transmembrane transport
AA2016_RS01705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS01730	COG0625	glutathione transferase activity
AA2016_RS01795	COG0582	viral genome integration into host DNA
AA2016_RS01825	COG2199	diguanylate cyclase activity
AA2016_RS01835	COG5001	Diguanylate cyclase
AA2016_RS01850	COG0583	DNA-binding transcription factor activity
AA2016_RS01860	COG2755	lipolytic protein G-D-S-L family
AA2016_RS01860	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AA2016_RS01900	COG1376	ErfK ybiS ycfS ynhG family protein
AA2016_RS01925	COG4964	Belongs to the GSP D family
AA2016_RS02000	COG4974	Belongs to the 'phage' integrase family
AA2016_RS02075	COG1072	(Pantothenic acid kinase))
AA2016_RS02080	COG0625	glutathione transferase activity
AA2016_RS02095	COG0829	nickel cation binding
AA2016_RS02100	COG0831	urea catabolic process
AA2016_RS02105	COG3813	Protein conserved in bacteria
AA2016_RS02115	COG0832	Belongs to the urease beta subunit family
AA2016_RS02140	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AA2016_RS02145	COG0830	nickel cation binding
AA2016_RS02155	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AA2016_RS02165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA2016_RS02180	COG0534	Mate efflux family protein
AA2016_RS02195	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_RS02200	COG3842	ATPase activity
AA2016_RS02210	COG0765	amino acid transport
AA2016_RS02215	COG0765	amino acid transport
AA2016_RS02230	COG0583	DNA-binding transcription factor activity
AA2016_RS02235	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AA2016_RS02260	COG1129	ABC transporter
AA2016_RS02275	COG1335	isochorismatase
AA2016_RS02305	COG1846	Transcriptional regulator
AA2016_RS02310	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_RS02315	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AA2016_RS02340	COG0673	inositol 2-dehydrogenase activity
AA2016_RS02345	COG0395	ABC-type sugar transport system, permease component
AA2016_RS02360	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AA2016_RS02365	COG2971	BadF BadG BcrA BcrD
AA2016_RS02370	COG2188	Transcriptional regulator
AA2016_RS02375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AA2016_RS02380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AA2016_RS02405	COG1879	ABC-type sugar transport system periplasmic component
AA2016_RS02415	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS02425	COG1609	Transcriptional regulator
AA2016_RS02445	COG4941	Belongs to the sigma-70 factor family
AA2016_RS02450	COG3795	YCII-related domain
AA2016_RS02455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AA2016_RS02500	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AA2016_RS02505	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AA2016_RS02510	COG4335	DNA alkylation repair
AA2016_RS02530	COG0121	glutamine amidotransferase
AA2016_RS02540	COG1522	sequence-specific DNA binding
AA2016_RS02545	COG0756	dUTP diphosphatase activity
AA2016_RS02550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA2016_RS02555	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AA2016_RS02565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA2016_RS02580	COG0281	malic enzyme
AA2016_RS02580	COG0280	phosphate acetyltransferase
AA2016_RS02585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AA2016_RS02615	COG0596	Alpha beta hydrolase
AA2016_RS02625	COG2207	Transcriptional regulator
AA2016_RS02625	COG0662	Cupin 2, conserved barrel domain protein
AA2016_RS02660	COG5001	Diguanylate cyclase
AA2016_RS02660	COG5002	protein histidine kinase activity
AA2016_RS02670	COG0656	L-ascorbic acid biosynthetic process
AA2016_RS02690	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AA2016_RS02695	COG0728	peptidoglycan biosynthetic process
AA2016_RS02710	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AA2016_RS02710	COG0463	Glycosyl transferase, family 2
AA2016_RS02715	COG0180	Tryptophanyl-tRNA synthetase
AA2016_RS02725	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AA2016_RS02730	COG1376	ErfK ybiS ycfS ynhG family protein
AA2016_RS02740	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AA2016_RS02750	COG1643	Atp-dependent helicase
AA2016_RS02760	COG0673	inositol 2-dehydrogenase activity
AA2016_RS02765	COG1737	Transcriptional regulator
AA2016_RS02770	COG0129	dihydroxy-acid dehydratase activity
AA2016_RS02790	COG0626	cystathionine gamma-synthase activity
AA2016_RS02795	COG1846	Transcriptional regulator
AA2016_RS02800	COG0697	spore germination
AA2016_RS02820	COG1116	anion transmembrane transporter activity
AA2016_RS02830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_RS02840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA2016_RS02860	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS02870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AA2016_RS02875	COG1802	Transcriptional regulator
AA2016_RS02880	COG0579	oxidoreductase
AA2016_RS02890	COG1522	sequence-specific DNA binding
AA2016_RS02895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AA2016_RS02900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_RS02905	COG2186	Transcriptional regulator
AA2016_RS02910	COG0626	cystathionine gamma-synthase activity
AA2016_RS02925	COG0395	ABC-type sugar transport system, permease component
AA2016_RS02930	COG3842	ATPase activity
AA2016_RS02935	COG0840	transmembrane signaling receptor activity
AA2016_RS02940	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA2016_RS02945	COG2201	protein-glutamate methylesterase activity
AA2016_RS02950	COG0745	RESPONSE REGULATOR receiver
AA2016_RS02955	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AA2016_RS03050	COG0156	8-amino-7-oxononanoate synthase activity
AA2016_RS03055	COG1063	alcohol dehydrogenase
AA2016_RS03065	COG4608	Belongs to the ABC transporter superfamily
AA2016_RS03075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS03080	COG0601	transmembrane transport
AA2016_RS03095	COG2186	Transcriptional regulator
AA2016_RS03110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AA2016_RS03115	COG0346	lactoylglutathione lyase activity
AA2016_RS03120	COG0346	lactoylglutathione lyase activity
AA2016_RS03130	COG2124	cytochrome p450
AA2016_RS03160	COG1846	Transcriptional regulator
AA2016_RS03165	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AA2016_RS03180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_RS03215	COG0436	Aminotransferase
AA2016_RS03225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA2016_RS03235	COG1473	amidohydrolase
AA2016_RS03240	COG1957	nucleoside hydrolase
AA2016_RS03245	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AA2016_RS03255	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_RS03260	COG3842	ATPase activity
AA2016_RS03265	COG1177	transmembrane transport
AA2016_RS03270	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_RS03290	COG0156	8-amino-7-oxononanoate synthase activity
AA2016_RS03300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS03305	COG0601	transmembrane transport
AA2016_RS03340	COG0747	negative chemotaxis
AA2016_RS03370	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AA2016_RS03375	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS03380	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AA2016_RS03385	COG0539	negative regulation of cytoplasmic translation
AA2016_RS03405	COG1309	transcriptional regulator
AA2016_RS03415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_RS03420	COG4215	(ABC) transporter
AA2016_RS03430	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AA2016_RS03460	COG1968	undecaprenyl-diphosphatase activity
AA2016_RS03470	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AA2016_RS03480	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
AA2016_RS03485	COG1803	Methylglyoxal synthase
AA2016_RS03490	COG0837	glucose binding
AA2016_RS03495	COG1132	(ABC) transporter
AA2016_RS03500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AA2016_RS03505	COG0588	phosphoglycerate mutase activity
AA2016_RS03560	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AA2016_RS03570	COG3386	PFAM SMP-30 Gluconolaconase
AA2016_RS03575	COG0800	Aldolase
AA2016_RS03580	COG3734	2-keto-3-deoxy-galactonokinase
AA2016_RS03585	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS03590	COG5001	Diguanylate cyclase
AA2016_RS03600	COG1309	transcriptional regulator
AA2016_RS03605	COG0189	ligase activity
AA2016_RS03620	COG5001	Diguanylate cyclase
AA2016_RS03645	COG0284	orotidine-5'-phosphate decarboxylase activity
AA2016_RS03655	COG3963	phosphatidate phosphatase activity
AA2016_RS03660	COG0484	heat shock protein binding
AA2016_RS03675	COG0443	Heat shock 70 kDa protein
AA2016_RS03700	COG3038	cytochrome b561
AA2016_RS03710	COG0072	phenylalanine-tRNA ligase activity
AA2016_RS03710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA2016_RS03720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AA2016_RS03725	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AA2016_RS03730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AA2016_RS03740	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AA2016_RS03750	COG3135	benzoate transporter
AA2016_RS03765	COG0583	DNA-binding transcription factor activity
AA2016_RS03770	COG0135	phosphoribosylanthranilate isomerase activity
AA2016_RS03775	COG0133	tryptophan synthase activity
AA2016_RS03780	COG0159	tryptophan synthase activity
AA2016_RS03785	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AA2016_RS03800	COG1074	ATP-dependent DNA helicase activity
AA2016_RS03810	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AA2016_RS03815	COG3178	'Phosphotransferase
AA2016_RS03820	COG2205	protein histidine kinase activity
AA2016_RS03825	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AA2016_RS03830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA2016_RS03835	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA2016_RS03835	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AA2016_RS03845	COG2205	protein histidine kinase activity
AA2016_RS03850	COG0745	RESPONSE REGULATOR receiver
AA2016_RS03855	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AA2016_RS03860	COG2801	Transposase and inactivated derivatives
AA2016_RS03875	COG1652	LysM domain
AA2016_RS03885	COG1072	(Pantothenic acid kinase))
AA2016_RS03890	COG0140	phosphoribosyl-ATP diphosphatase activity
AA2016_RS03900	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AA2016_RS03910	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AA2016_RS03920	COG0131	Imidazoleglycerol-phosphate dehydratase
AA2016_RS03925	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AA2016_RS03945	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AA2016_RS03955	COG1396	sequence-specific DNA binding
AA2016_RS03955	COG3800	Transcriptional regulator
AA2016_RS03975	COG3030	protein affecting phage T7 exclusion by the F plasmid
AA2016_RS03980	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AA2016_RS03985	COG2801	Transposase and inactivated derivatives
AA2016_RS03995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AA2016_RS04000	COG0237	dephospho-CoA kinase activity
AA2016_RS04005	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AA2016_RS04010	COG0424	maF-like protein
AA2016_RS04015	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AA2016_RS04020	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AA2016_RS04025	COG1981	membrane
AA2016_RS04030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AA2016_RS04035	COG1331	Highly conserved protein containing a thioredoxin domain
AA2016_RS04040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AA2016_RS04045	COG0445	tRNA wobble uridine modification
AA2016_RS04050	COG0357	Ribosomal RNA small subunit methyltransferase G
AA2016_RS04120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA2016_RS04130	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA2016_RS04130	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA2016_RS04135	COG4770	biotin carboxylase activity
AA2016_RS04140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA2016_RS04150	COG1396	sequence-specific DNA binding
AA2016_RS04150	COG3800	Transcriptional regulator
AA2016_RS04160	COG2183	response to ionizing radiation
AA2016_RS04165	COG0137	argininosuccinate synthase activity
AA2016_RS04195	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AA2016_RS04200	COG1605	Chorismate mutase
AA2016_RS04200	COG0287	Prephenate dehydrogenase
AA2016_RS04205	COG0228	four-way junction DNA binding
AA2016_RS04210	COG5001	Diguanylate cyclase
AA2016_RS04210	COG3300	MHYT domain
AA2016_RS04220	COG3781	membrane
AA2016_RS04230	COG0454	-acetyltransferase
AA2016_RS04235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AA2016_RS04250	COG4178	(ABC) transporter
AA2016_RS04255	COG3152	Membrane
AA2016_RS04260	COG0473	3-isopropylmalate dehydrogenase activity
AA2016_RS04270	COG0251	oxidation-reduction process
AA2016_RS04285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AA2016_RS04290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA2016_RS04295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA2016_RS04300	COG1120	ATPase activity
AA2016_RS04305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA2016_RS04315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA2016_RS04320	COG0525	valine-tRNA ligase activity
AA2016_RS04325	COG0765	amino acid transport
AA2016_RS04330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_RS04345	COG2814	Major facilitator Superfamily
AA2016_RS04375	COG1595	DNA-templated transcription, initiation
AA2016_RS04410	COG2195	Cleaves the N-terminal amino acid of tripeptides
AA2016_RS04425	COG2301	Belongs to the HpcH HpaI aldolase family
AA2016_RS04450	COG0587	DNA-directed DNA polymerase activity
AA2016_RS04455	COG2835	tetraacyldisaccharide 4'-kinase activity
AA2016_RS04460	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AA2016_RS04465	COG3118	belongs to the thioredoxin family
AA2016_RS04485	COG0010	Belongs to the arginase family
AA2016_RS04490	COG0436	Aminotransferase
AA2016_RS04510	COG0463	Glycosyl transferase, family 2
AA2016_RS04515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA2016_RS04520	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS04525	COG4948	Mandelate Racemase Muconate Lactonizing
AA2016_RS04530	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA2016_RS04540	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS04545	COG1129	ABC transporter
AA2016_RS04555	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS04565	COG4154	Belongs to the RbsD FucU family
AA2016_RS04570	COG4608	Belongs to the ABC transporter superfamily
AA2016_RS04575	COG0444	Belongs to the ABC transporter superfamily
AA2016_RS04580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS04585	COG0601	transmembrane transport
AA2016_RS04590	COG0747	negative chemotaxis
AA2016_RS04600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AA2016_RS04615	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AA2016_RS04635	COG3339	Conserved Protein
AA2016_RS04640	COG2154	pterin-4-alpha-carbinolamine dehydratase
AA2016_RS04645	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AA2016_RS04660	COG1136	(ABC) transporter
AA2016_RS04665	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AA2016_RS04670	COG0670	Belongs to the BI1 family
AA2016_RS04680	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AA2016_RS04685	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_RS04705	COG1276	copper resistance
AA2016_RS04705	COG2372	response to copper ion
AA2016_RS04720	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS04725	COG3300	MHYT domain
AA2016_RS04725	COG5001	Diguanylate cyclase
AA2016_RS04760	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AA2016_RS04770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AA2016_RS04775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA2016_RS04780	COG0552	protein localization to endoplasmic reticulum
AA2016_RS04785	COG2917	probably involved in intracellular septation
AA2016_RS04795	COG0431	NADPH-dependent FMN reductase
AA2016_RS04805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA2016_RS04815	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AA2016_RS04820	COG4133	protoheme IX ABC transporter activity
AA2016_RS04825	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AA2016_RS04835	COG0039	L-malate dehydrogenase activity
AA2016_RS04840	COG0045	succinate-CoA ligase (ADP-forming) activity
AA2016_RS04845	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AA2016_RS04850	COG0567	Dehydrogenase, E1 component
AA2016_RS04855	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA2016_RS04870	COG1280	lysine exporter protein (LysE YggA)
AA2016_RS04880	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS04905	COG4974	Belongs to the 'phage' integrase family
AA2016_RS04910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AA2016_RS04915	COG0336	Belongs to the RNA methyltransferase TrmD family
AA2016_RS04925	COG0335	large ribosomal subunit rRNA binding
AA2016_RS04930	COG0456	acetyltransferase
AA2016_RS04950	COG0765	amino acid transport
AA2016_RS04985	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AA2016_RS05000	COG2009	succinate dehydrogenase
AA2016_RS05030	COG3132	Protein of unknown function, DUF480
AA2016_RS05035	COG3541	Predicted nucleotidyltransferase
AA2016_RS05050	COG1764	response to oxidative stress
AA2016_RS05055	COG3795	YCII-related domain
AA2016_RS05060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA2016_RS05065	COG1946	Acyl-CoA thioesterase
AA2016_RS05070	COG0347	Belongs to the P(II) protein family
AA2016_RS05075	COG0004	ammonium transporteR
AA2016_RS05095	COG1674	ftsk spoiiie
AA2016_RS05095	COG2261	transglycosylase associated protein
AA2016_RS05100	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AA2016_RS05115	COG0745	RESPONSE REGULATOR receiver
AA2016_RS05130	COG0583	DNA-binding transcription factor activity
AA2016_RS05135	COG2264	protein methyltransferase activity
AA2016_RS05150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AA2016_RS05155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AA2016_RS05160	COG0181	hydroxymethylbilane synthase activity
AA2016_RS05185	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AA2016_RS05210	COG3307	-O-antigen
AA2016_RS05215	COG1596	polysaccharide export
AA2016_RS05230	COG1215	transferase activity, transferring glycosyl groups
AA2016_RS05240	COG2273	Hydrolase Family 16
AA2016_RS05270	COG0438	transferase activity, transferring glycosyl groups
AA2016_RS05275	COG1215	transferase activity, transferring glycosyl groups
AA2016_RS05280	COG1215	transferase activity, transferring glycosyl groups
AA2016_RS05285	COG1215	transferase activity, transferring glycosyl groups
AA2016_RS05290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AA2016_RS05295	COG3206	protein involved in exopolysaccharide biosynthesis
AA2016_RS05295	COG0489	protein tyrosine kinase activity
AA2016_RS05300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AA2016_RS05310	COG3920	Histidine kinase
AA2016_RS05315	COG2755	lipolytic protein G-D-S-L family
AA2016_RS05315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AA2016_RS05325	COG3239	Fatty acid desaturase
AA2016_RS05340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AA2016_RS05345	COG0747	negative chemotaxis
AA2016_RS05350	COG0601	transmembrane transport
AA2016_RS05355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS05360	COG4172	Belongs to the ABC transporter superfamily
AA2016_RS05375	COG3284	Transcriptional regulator
AA2016_RS05400	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_RS05410	COG3119	arylsulfatase activity
AA2016_RS05430	COG1940	carbohydrate kinase activity
AA2016_RS05435	COG0730	response to heat
AA2016_RS05440	COG1879	ABC-type sugar transport system periplasmic component
AA2016_RS05445	COG1802	Transcriptional regulator
AA2016_RS05450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA2016_RS05465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2016_RS05475	COG0778	Nitroreductase
AA2016_RS05485	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA2016_RS05500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_RS05515	COG0840	transmembrane signaling receptor activity
AA2016_RS05515	COG2972	Histidine kinase
AA2016_RS05520	COG0601	transmembrane transport
AA2016_RS05525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS05535	COG1228	amidohydrolase
AA2016_RS05540	COG0444	Belongs to the ABC transporter superfamily
AA2016_RS05545	COG4608	Belongs to the ABC transporter superfamily
AA2016_RS05550	COG1802	Transcriptional regulator
AA2016_RS05555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA2016_RS05565	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_RS05570	COG0747	negative chemotaxis
AA2016_RS05575	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_RS05585	COG0747	negative chemotaxis
AA2016_RS05595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS05600	COG0601	transmembrane transport
AA2016_RS05605	COG1802	Transcriptional regulator
AA2016_RS05630	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_RS05635	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS05695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA2016_RS05705	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AA2016_RS05720	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AA2016_RS05725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA2016_RS05740	COG0583	DNA-binding transcription factor activity
AA2016_RS05755	COG2222	sugar isomerase
AA2016_RS05760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA2016_RS05765	COG4172	Belongs to the ABC transporter superfamily
AA2016_RS05770	COG0601	transmembrane transport
AA2016_RS05775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS05795	COG3547	Transposase (IS116 IS110 IS902 family)
AA2016_RS05825	COG2186	Transcriptional regulator
AA2016_RS05830	COG4638	Rieske (2fe-2S)
AA2016_RS05850	COG3842	ATPase activity
AA2016_RS05855	COG1178	ABC-type Fe3 transport system permease component
AA2016_RS05865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2016_RS05870	COG1177	transmembrane transport
AA2016_RS05880	COG3842	ATPase activity
AA2016_RS05885	COG0028	Belongs to the TPP enzyme family
AA2016_RS05890	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AA2016_RS05920	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_RS05925	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AA2016_RS05935	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AA2016_RS05940	COG4638	Rieske (2fe-2S)
AA2016_RS05945	COG2186	Transcriptional regulator
AA2016_RS05965	COG0129	dihydroxy-acid dehydratase activity
AA2016_RS05970	COG0163	prenyltransferase activity
AA2016_RS06015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA2016_RS06040	COG1525	nuclease
AA2016_RS06055	COG5410	chromosome segregation
AA2016_RS06095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA2016_RS06100	COG1061	Type III restriction enzyme res subunit
AA2016_RS06110	COG1002	Type II restriction enzyme, methylase subunits
AA2016_RS06150	COG1872	DUF167
AA2016_RS06160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AA2016_RS06180	COG1704	LemA family
AA2016_RS06220	COG2814	Major facilitator Superfamily
AA2016_RS06225	COG1846	Transcriptional regulator
AA2016_RS06230	COG0339	signal peptide processing
AA2016_RS06240	COG1217	gtp-binding protein TYPA
AA2016_RS06260	COG2270	Major facilitator Superfamily
AA2016_RS06265	COG0138	bifunctional purine biosynthesis protein purh
AA2016_RS06275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA2016_RS06275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA2016_RS06280	COG0501	Belongs to the peptidase M48B family
AA2016_RS06305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AA2016_RS06310	COG0789	Transcriptional regulator
AA2016_RS06320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA2016_RS06325	COG5425	PFAM Usg family protein
AA2016_RS06335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AA2016_RS06340	COG0495	leucyl-tRNA aminoacylation
AA2016_RS06350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA2016_RS06360	COG1522	sequence-specific DNA binding
AA2016_RS06365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AA2016_RS06385	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AA2016_RS06395	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AA2016_RS06400	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AA2016_RS06405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AA2016_RS06410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA2016_RS06415	COG0590	tRNA wobble adenosine to inosine editing
AA2016_RS06430	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AA2016_RS06440	COG1091	dTDP-4-dehydrorhamnose reductase activity
AA2016_RS06450	COG3754	Rhamnan synthesis protein F
AA2016_RS06480	COG3743	rRNA binding
AA2016_RS06480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AA2016_RS06485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AA2016_RS06500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AA2016_RS06505	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AA2016_RS06510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AA2016_RS06515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AA2016_RS06530	COG0799	negative regulation of ribosome biogenesis
AA2016_RS06535	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AA2016_RS06545	COG0793	Belongs to the peptidase S41A family
AA2016_RS06555	COG0494	nUDIX hydrolase
AA2016_RS06560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA2016_RS06570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_RS06600	COG3655	Transcriptional regulator
AA2016_RS06625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2016_RS06630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_RS06675	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AA2016_RS06685	COG2223	nitrite transmembrane transporter activity
AA2016_RS06690	COG0583	DNA-binding transcription factor activity
AA2016_RS06705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA2016_RS06720	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS06730	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AA2016_RS06735	COG0741	lytic transglycosylase activity
AA2016_RS06740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA2016_RS06755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AA2016_RS06760	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AA2016_RS06775	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AA2016_RS06780	COG0183	Belongs to the thiolase family
AA2016_RS06785	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS06795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AA2016_RS06810	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AA2016_RS06815	COG1329	Transcriptional regulator
AA2016_RS06825	COG1126	abc transporter atp-binding protein
AA2016_RS06830	COG0765	amino acid transport
AA2016_RS06835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_RS06840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA2016_RS06850	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AA2016_RS06870	COG0488	(ABC) transporter
AA2016_RS06885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AA2016_RS06895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA2016_RS06900	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AA2016_RS06920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA2016_RS06935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA2016_RS06940	COG0037	tRNA processing
AA2016_RS06950	COG2885	chlorophyll binding
AA2016_RS06965	COG0848	biopolymer transport protein
AA2016_RS06975	COG0824	Thioesterase
AA2016_RS06980	COG2226	methyltransferase
AA2016_RS06990	COG1408	metallophosphoesterase
AA2016_RS07000	COG2255	four-way junction helicase activity
AA2016_RS07025	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AA2016_RS07045	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_RS07065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AA2016_RS07070	COG0483	inositol monophosphate 1-phosphatase activity
AA2016_RS07075	COG1272	protein, Hemolysin III
AA2016_RS07125	COG0778	Nitroreductase
AA2016_RS07130	COG1132	(ABC) transporter
AA2016_RS07135	COG0254	rRNA binding
AA2016_RS07150	COG0702	epimerase
AA2016_RS07160	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA2016_RS07170	COG0217	transcriptional regulatory protein
AA2016_RS07185	COG0625	glutathione transferase activity
AA2016_RS07190	COG1733	regulation of RNA biosynthetic process
AA2016_RS07215	COG0861	Integral membrane protein TerC family
AA2016_RS07220	COG1692	metallophosphoesterase
AA2016_RS07225	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AA2016_RS07255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA2016_RS07275	COG0583	DNA-binding transcription factor activity
AA2016_RS07280	COG0431	NADPH-dependent FMN reductase
AA2016_RS07285	COG3750	Belongs to the UPF0335 family
AA2016_RS07305	COG0469	pyruvate kinase activity
AA2016_RS07310	COG2267	carboxylic ester hydrolase activity
AA2016_RS07315	COG0457	Tetratricopeptide repeat
AA2016_RS07320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AA2016_RS07325	COG3755	Protein conserved in bacteria
AA2016_RS07330	COG1733	regulation of RNA biosynthetic process
AA2016_RS07345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AA2016_RS07365	COG0640	Transcriptional regulator
AA2016_RS07380	COG0604	alcohol dehydrogenase
AA2016_RS07380	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS07380	COG3321	synthase
AA2016_RS07385	COG2226	methyltransferase
AA2016_RS07395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_RS07405	COG0145	ligase activity
AA2016_RS07410	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AA2016_RS07440	COG0045	succinate-CoA ligase (ADP-forming) activity
AA2016_RS07440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA2016_RS07440	COG1042	CoA-binding domain protein
AA2016_RS07450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA2016_RS07455	COG0697	spore germination
AA2016_RS07470	COG0183	Belongs to the thiolase family
AA2016_RS07490	COG4191	Histidine kinase
AA2016_RS07515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA2016_RS07540	COG2801	Transposase and inactivated derivatives
AA2016_RS07615	COG2268	Band 7 protein
AA2016_RS07635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AA2016_RS07690	COG2801	Transposase and inactivated derivatives
AA2016_RS07700	COG3588	fructose-bisphosphate aldolase
AA2016_RS07710	COG0126	phosphoglycerate kinase activity
AA2016_RS07755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA2016_RS07760	COG0564	pseudouridine synthase activity
AA2016_RS07770	COG0346	lactoylglutathione lyase activity
AA2016_RS07925	COG0573	inorganic phosphate transmembrane transporter activity
AA2016_RS07935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AA2016_RS07940	COG0704	Plays a role in the regulation of phosphate uptake
AA2016_RS07945	COG0745	RESPONSE REGULATOR receiver
AA2016_RS07955	COG4213	ABC transporter substrate-binding protein
AA2016_RS07960	COG4214	carbohydrate transport
AA2016_RS07985	COG2202	Pas domain
AA2016_RS07985	COG3920	Histidine kinase
AA2016_RS07990	COG0784	Response regulator, receiver
AA2016_RS08005	COG0784	Response regulator, receiver
AA2016_RS08010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA2016_RS08015	COG0628	permease
AA2016_RS08045	COG0346	lactoylglutathione lyase activity
AA2016_RS08050	COG0400	carboxylic ester hydrolase activity
AA2016_RS08070	COG2203	Gaf domain
AA2016_RS08070	COG2200	EAL domain
AA2016_RS08070	COG2199	diguanylate cyclase activity
AA2016_RS08075	COG0745	RESPONSE REGULATOR receiver
AA2016_RS08080	COG0745	RESPONSE REGULATOR receiver
AA2016_RS08095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA2016_RS08100	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AA2016_RS08105	COG3833	ABC-type maltose transport systems, permease component
AA2016_RS08110	COG3842	ATPase activity
AA2016_RS08125	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AA2016_RS08135	COG0483	inositol monophosphate 1-phosphatase activity
AA2016_RS08160	COG1840	ABC-type Fe3 transport system, periplasmic component
AA2016_RS08170	COG3842	ATPase activity
AA2016_RS08175	COG1238	metal cluster binding
AA2016_RS08185	COG2132	Multicopper oxidase
AA2016_RS08215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA2016_RS08220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA2016_RS08230	COG1845	cytochrome c oxidase, subunit III
AA2016_RS08245	COG0406	alpha-ribazole phosphatase activity
AA2016_RS08250	COG3842	ATPase activity
AA2016_RS08255	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AA2016_RS08275	COG1737	Transcriptional regulator
AA2016_RS08285	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS08300	COG0395	ABC-type sugar transport system, permease component
AA2016_RS08310	COG1079	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS08315	COG4603	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS08320	COG3845	ABC transporter
AA2016_RS08330	COG2186	Transcriptional regulator
AA2016_RS08350	COG0625	glutathione transferase activity
AA2016_RS08355	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AA2016_RS08360	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AA2016_RS08365	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AA2016_RS08365	COG0351	phosphomethylpyrimidine kinase
AA2016_RS08365	COG0352	thiamine-phosphate diphosphorylase activity
AA2016_RS08375	COG2022	thiamine diphosphate biosynthetic process
AA2016_RS08390	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AA2016_RS08415	COG0356	it plays a direct role in the translocation of protons across the membrane
AA2016_RS08430	COG1473	amidohydrolase
AA2016_RS08435	COG1686	Belongs to the peptidase S11 family
AA2016_RS08440	COG0523	cobalamin synthesis protein
AA2016_RS08445	COG0425	Belongs to the sulfur carrier protein TusA family
AA2016_RS08455	COG0825	malonyl-CoA metabolic process
AA2016_RS08470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AA2016_RS08475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AA2016_RS08480	COG4536	flavin adenine dinucleotide binding
AA2016_RS08535	COG1522	sequence-specific DNA binding
AA2016_RS08560	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AA2016_RS08565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AA2016_RS08580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA2016_RS08585	COG2226	methyltransferase
AA2016_RS08600	COG1597	lipid kinase activity
AA2016_RS08610	COG2814	Major facilitator Superfamily
AA2016_RS08615	COG0583	DNA-binding transcription factor activity
AA2016_RS08620	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AA2016_RS08625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AA2016_RS08630	COG0287	Prephenate dehydrogenase
AA2016_RS08645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AA2016_RS08645	COG2169	Transcriptional regulator
AA2016_RS08670	COG2884	Cell division ATP-binding protein ftsE
AA2016_RS08680	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AA2016_RS08695	COG0583	DNA-binding transcription factor activity
AA2016_RS08710	COG0019	diaminopimelate decarboxylase activity
AA2016_RS08720	COG0165	Argininosuccinate lyase
AA2016_RS08725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA2016_RS08730	COG1653	transport
AA2016_RS08735	COG1175	transmembrane transport
AA2016_RS08740	COG0395	ABC-type sugar transport system, permease component
AA2016_RS08745	COG3842	ATPase activity
AA2016_RS08755	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA2016_RS08760	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AA2016_RS08765	COG2086	electron transfer activity
AA2016_RS08785	COG0300	oxidoreductase activity
AA2016_RS08795	COG0697	spore germination
AA2016_RS08805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA2016_RS08825	COG1238	metal cluster binding
AA2016_RS08855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA2016_RS08875	COG2239	Acts as a magnesium transporter
AA2016_RS08880	COG0653	protein targeting
AA2016_RS08885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA2016_RS08905	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AA2016_RS08910	COG0456	acetyltransferase
AA2016_RS08915	COG0494	nUDIX hydrolase
AA2016_RS08925	COG2226	methyltransferase
AA2016_RS08930	COG1040	competence protein
AA2016_RS08940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA2016_RS08965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA2016_RS08970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA2016_RS08975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA2016_RS08980	COG0527	aspartate kinase activity
AA2016_RS08990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AA2016_RS08995	COG2890	protein-(glutamine-N5) methyltransferase activity
AA2016_RS09005	COG0542	response to heat
AA2016_RS09015	COG1376	ErfK ybiS ycfS ynhG family protein
AA2016_RS09040	COG0625	glutathione transferase activity
AA2016_RS09045	COG0477	Major facilitator Superfamily
AA2016_RS09050	COG0739	heme binding
AA2016_RS09050	COG1196	nuclear chromosome segregation
AA2016_RS09050	COG0741	lytic transglycosylase activity
AA2016_RS09095	COG4176	ABC-type proline glycine betaine transport system permease component
AA2016_RS09100	COG3448	diguanylate cyclase activity
AA2016_RS09100	COG4175	Glycine betaine
AA2016_RS09110	COG0745	RESPONSE REGULATOR receiver
AA2016_RS09115	COG2205	protein histidine kinase activity
AA2016_RS09125	COG0745	RESPONSE REGULATOR receiver
AA2016_RS09135	COG1879	ABC-type sugar transport system periplasmic component
AA2016_RS09140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_RS09150	COG3842	ATPase activity
AA2016_RS09170	COG1070	Carbohydrate kinase
AA2016_RS09180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AA2016_RS09185	COG0667	Aldo Keto reductase
AA2016_RS09195	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS09200	COG1129	ABC transporter
AA2016_RS09210	COG2358	TRAP transporter, solute receptor (TAXI family
AA2016_RS09220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_RS09230	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AA2016_RS09270	COG0463	Glycosyl transferase, family 2
AA2016_RS09275	COG1215	transferase activity, transferring glycosyl groups
AA2016_RS09290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA2016_RS09295	COG1120	ATPase activity
AA2016_RS09300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA2016_RS09315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA2016_RS09320	COG0205	6-phosphofructokinase activity
AA2016_RS09325	COG1388	LysM domain
AA2016_RS09325	COG1376	ErfK ybiS ycfS ynhG family protein
AA2016_RS09330	COG1280	lysine exporter protein (LysE YggA)
AA2016_RS09340	COG1070	Carbohydrate kinase
AA2016_RS09350	COG2115	Belongs to the xylose isomerase family
AA2016_RS09370	COG4977	sequence-specific DNA binding
AA2016_RS09375	COG3246	L-lysine catabolic process to acetate
AA2016_RS09380	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA2016_RS09400	COG0657	acetylesterase activity
AA2016_RS09410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS09435	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AA2016_RS09440	COG3257	ureidoglycine aminohydrolase activity
AA2016_RS09450	COG2351	hydroxyisourate hydrolase activity
AA2016_RS09460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AA2016_RS09470	COG0783	Belongs to the Dps family
AA2016_RS09485	COG0583	DNA-binding transcription factor activity
AA2016_RS09495	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_RS09500	COG4702	Belongs to the UPF0303 family
AA2016_RS09520	COG0174	glutamine synthetase
AA2016_RS09550	COG0523	cobalamin synthesis protein
AA2016_RS09560	COG1846	Transcriptional regulator
AA2016_RS09575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA2016_RS09590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AA2016_RS09595	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AA2016_RS09600	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AA2016_RS09615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AA2016_RS09645	COG5001	Diguanylate cyclase
AA2016_RS09685	COG1280	lysine exporter protein (LysE YggA)
AA2016_RS09695	COG2249	NAD(P)H dehydrogenase (quinone) activity
AA2016_RS09705	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AA2016_RS09725	COG2223	nitrite transmembrane transporter activity
AA2016_RS09740	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS09750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_RS09765	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA2016_RS09765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_RS09825	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AA2016_RS09865	COG3842	ATPase activity
AA2016_RS09870	COG0583	DNA-binding transcription factor activity
AA2016_RS09875	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AA2016_RS09880	COG3842	ATPase activity
AA2016_RS09885	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_RS09890	COG1177	transmembrane transport
AA2016_RS09895	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_RS09910	COG1609	Transcriptional regulator
AA2016_RS09925	COG1024	Enoyl-CoA hydratase
AA2016_RS09930	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_RS09935	COG1653	transport
AA2016_RS09945	COG0395	ABC-type sugar transport system, permease component
AA2016_RS09950	COG3842	ATPase activity
AA2016_RS09960	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS09970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AA2016_RS09975	COG3774	pathogenesis
AA2016_RS09980	COG4608	Belongs to the ABC transporter superfamily
AA2016_RS09985	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_RS09990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS10000	COG4533	DNA binding
AA2016_RS10005	COG0444	Belongs to the ABC transporter superfamily
AA2016_RS10035	COG2072	flavoprotein involved in K transport
AA2016_RS10065	COG0071	Belongs to the small heat shock protein (HSP20) family
AA2016_RS10080	COG0069	glutamate synthase activity
AA2016_RS10080	COG0070	glutamate synthase
AA2016_RS10080	COG0067	glutamate synthase
AA2016_RS10095	COG2951	lytic endotransglycosylase activity
AA2016_RS10100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AA2016_RS10105	COG0778	Nitroreductase
AA2016_RS10130	COG1585	Membrane protein implicated in regulation of membrane protease activity
AA2016_RS10135	COG0330	HflC and HflK could
AA2016_RS10140	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AA2016_RS10140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_RS10145	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AA2016_RS10150	COG0737	Belongs to the 5'-nucleotidase family
AA2016_RS10160	COG3775	system Galactitol-specific IIC component
AA2016_RS10175	COG5310	Homospermidine synthase
AA2016_RS10210	COG2204	response regulator
AA2016_RS10215	COG3108	Peptidase M15
AA2016_RS10220	COG0800	Aldolase
AA2016_RS10230	COG1054	Belongs to the UPF0176 family
AA2016_RS10240	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS10300	COG0583	DNA-binding transcription factor activity
AA2016_RS10305	COG0154	amidase activity
AA2016_RS10330	COG2801	Transposase and inactivated derivatives
AA2016_RS10365	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AA2016_RS10370	COG2814	Major facilitator Superfamily
AA2016_RS10380	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AA2016_RS10385	COG5443	negative regulation of bacterial-type flagellum assembly
AA2016_RS10390	COG5442	Flagellar protein FlaF
AA2016_RS10405	COG1749	Flagellar hook protein flgE
AA2016_RS10445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AA2016_RS10450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AA2016_RS10455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AA2016_RS10465	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AA2016_RS10470	COG1338	Plays a role in the flagellum-specific transport system
AA2016_RS10480	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AA2016_RS10490	COG1706	bacterial-type flagellum-dependent cell motility
AA2016_RS10495	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
AA2016_RS10500	COG4786	Flagellar basal body rod
AA2016_RS10505	COG1677	Flagellar hook-basal body complex protein FliE
AA2016_RS10510	COG1558	bacterial-type flagellum-dependent cell motility
AA2016_RS10515	COG1815	bacterial-type flagellum-dependent cell motility
AA2016_RS10525	COG1157	protein secretion by the type III secretion system
AA2016_RS10530	COG4786	Flagellar basal body rod
AA2016_RS10540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AA2016_RS10550	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AA2016_RS10555	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AA2016_RS10560	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AA2016_RS10575	COG2771	luxR family
AA2016_RS10590	COG1309	transcriptional regulator
AA2016_RS10595	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AA2016_RS10600	COG3842	ATPase activity
AA2016_RS10610	COG1177	transmembrane transport
AA2016_RS10640	COG4213	ABC transporter substrate-binding protein
AA2016_RS10645	COG1129	ABC transporter
AA2016_RS10650	COG4214	carbohydrate transport
AA2016_RS10700	COG1129	ABC transporter
AA2016_RS10705	COG4211	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS10710	COG0673	inositol 2-dehydrogenase activity
AA2016_RS10715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA2016_RS10720	COG3962	Belongs to the TPP enzyme family
AA2016_RS10725	COG1082	Xylose isomerase domain protein TIM barrel
AA2016_RS10735	COG3718	enzyme involved in inositol metabolism
AA2016_RS10740	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AA2016_RS10770	COG2197	response regulator
AA2016_RS10790	COG0747	negative chemotaxis
AA2016_RS10810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA2016_RS10815	COG0747	negative chemotaxis
AA2016_RS10830	COG3454	Phosphonate metabolism
AA2016_RS10835	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AA2016_RS10840	COG3639	organic phosphonate transmembrane transporter activity
AA2016_RS10855	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AA2016_RS10860	COG1733	regulation of RNA biosynthetic process
AA2016_RS10875	COG0786	glutamate:sodium symporter activity
AA2016_RS10885	COG4778	phosphonate C-P lyase system protein PhnL
AA2016_RS10890	COG4107	phosphonate C-P lyase system protein PhnK
AA2016_RS10895	COG3627	carbon phosphorus lyase activity
AA2016_RS10900	COG3626	phosphonate metabolism
AA2016_RS10905	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
AA2016_RS10910	COG3624	Phosphonate C-P lyase system protein PhnG
AA2016_RS10915	COG2188	Transcriptional regulator
AA2016_RS10930	COG1177	transmembrane transport
AA2016_RS10940	COG2072	flavoprotein involved in K transport
AA2016_RS10955	COG3620	sequence-specific DNA binding
AA2016_RS10985	COG0583	DNA-binding transcription factor activity
AA2016_RS10990	COG3842	ATPase activity
AA2016_RS11000	COG1175	transmembrane transport
AA2016_RS11190	COG0740	serine-type endopeptidase activity
AA2016_RS11320	COG3620	sequence-specific DNA binding
AA2016_RS11365	COG5377	YqaJ viral recombinase family
AA2016_RS11405	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA2016_RS11405	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AA2016_RS11455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AA2016_RS11460	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AA2016_RS11540	COG0482	sulfurtransferase activity
AA2016_RS11555	COG0604	alcohol dehydrogenase
AA2016_RS11560	COG1733	regulation of RNA biosynthetic process
AA2016_RS11575	COG2201	protein-glutamate methylesterase activity
AA2016_RS11620	COG0435	Glutathione S-transferase
AA2016_RS11625	COG0494	nUDIX hydrolase
AA2016_RS11640	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA2016_RS11640	COG0596	Alpha beta hydrolase
AA2016_RS11650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA2016_RS11660	COG3180	Ammonia monooxygenase
AA2016_RS11690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AA2016_RS11690	COG0512	Glutamine amidotransferase of anthranilate synthase
AA2016_RS11695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA2016_RS11705	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AA2016_RS11710	COG2814	Major facilitator Superfamily
AA2016_RS11715	COG4993	Dehydrogenase
AA2016_RS11725	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AA2016_RS11745	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AA2016_RS11780	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AA2016_RS11815	COG1435	thymidine kinase activity
AA2016_RS11825	COG4176	ABC-type proline glycine betaine transport system permease component
AA2016_RS11830	COG4175	Glycine betaine
AA2016_RS11830	COG3448	diguanylate cyclase activity
AA2016_RS11850	COG5507	3-demethylubiquinone-9 3-methyltransferase
AA2016_RS11855	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AA2016_RS11875	COG1278	Cold shock
AA2016_RS11895	COG0714	Associated with various cellular activities
AA2016_RS11905	COG0494	nUDIX hydrolase
AA2016_RS11910	COG0617	tRNA 3'-terminal CCA addition
AA2016_RS11930	COG0408	coproporphyrinogen oxidase activity
AA2016_RS11960	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AA2016_RS11970	COG1132	(ABC) transporter
AA2016_RS11975	COG1132	(ABC) transporter
AA2016_RS11980	COG1132	(ABC) transporter
AA2016_RS12000	COG2857	Cytochrome c1
AA2016_RS12000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AA2016_RS12005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AA2016_RS12035	COG0012	GTP binding
AA2016_RS12040	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AA2016_RS12045	COG0193	aminoacyl-tRNA hydrolase activity
AA2016_RS12050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AA2016_RS12070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AA2016_RS12085	COG1496	oxidoreductase activity
AA2016_RS12095	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AA2016_RS12110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA2016_RS12120	COG1464	Belongs to the NlpA lipoprotein family
AA2016_RS12125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AA2016_RS12130	COG2011	ABC-type metal ion transport system permease component
AA2016_RS12135	COG2205	protein histidine kinase activity
AA2016_RS12145	COG0745	RESPONSE REGULATOR receiver
AA2016_RS12150	COG1846	Transcriptional regulator
AA2016_RS12155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AA2016_RS12165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA2016_RS12175	COG1278	Cold shock
AA2016_RS12185	COG1278	Cold shock
AA2016_RS12210	COG0583	DNA-binding transcription factor activity
AA2016_RS12220	COG1819	glycosyl
AA2016_RS12230	COG1794	racemase activity, acting on amino acids and derivatives
AA2016_RS12240	COG3791	Glutathione-dependent formaldehyde-activating
AA2016_RS12250	COG0726	polysaccharide deacetylase
AA2016_RS12270	COG1396	sequence-specific DNA binding
AA2016_RS12305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA2016_RS12315	COG1522	sequence-specific DNA binding
AA2016_RS12330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2016_RS12350	COG0583	DNA-binding transcription factor activity
AA2016_RS12360	COG0556	nucleotide-excision repair
AA2016_RS12370	COG0438	transferase activity, transferring glycosyl groups
AA2016_RS12400	COG1597	lipid kinase activity
AA2016_RS12410	COG2084	Dehydrogenase
AA2016_RS12415	COG4948	Mandelate Racemase Muconate Lactonizing
AA2016_RS12440	COG1253	flavin adenine dinucleotide binding
AA2016_RS12485	COG0583	DNA-binding transcription factor activity
AA2016_RS12495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA2016_RS12505	COG2133	pyrroloquinoline quinone binding
AA2016_RS12510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA2016_RS12525	COG3306	glycosyltransferase involved in LPS biosynthesis
AA2016_RS12530	COG3306	glycosyltransferase involved in LPS biosynthesis
AA2016_RS12540	COG1522	sequence-specific DNA binding
AA2016_RS12545	COG0492	ferredoxin-NADP+ reductase activity
AA2016_RS12550	COG0583	DNA-binding transcription factor activity
AA2016_RS12555	COG0640	Transcriptional regulator
AA2016_RS12580	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AA2016_RS12585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA2016_RS12600	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AA2016_RS12615	COG0477	Major facilitator Superfamily
AA2016_RS12640	COG0436	Aminotransferase
AA2016_RS12660	COG1278	Cold shock
AA2016_RS12670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AA2016_RS12695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AA2016_RS12705	COG2130	NADP-dependent
AA2016_RS12715	COG3591	Belongs to the peptidase S1B family
AA2016_RS12715	COG1864	DNA RNA non-specific endonuclease
AA2016_RS12730	COG2814	Major facilitator Superfamily
AA2016_RS12740	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_RS12750	COG2321	neutral zinc metallopeptidase
AA2016_RS12800	COG0505	Belongs to the CarA family
AA2016_RS12815	COG1473	amidohydrolase
AA2016_RS12825	COG0358	DNA primase activity
AA2016_RS12830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA2016_RS12845	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AA2016_RS12860	COG0372	Belongs to the citrate synthase family
AA2016_RS12865	COG0372	Belongs to the citrate synthase family
AA2016_RS12905	COG1280	lysine exporter protein (LysE YggA)
AA2016_RS12950	COG0488	(ABC) transporter
AA2016_RS12965	COG1522	sequence-specific DNA binding
AA2016_RS12975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AA2016_RS12980	COG0583	DNA-binding transcription factor activity
AA2016_RS12985	COG1309	transcriptional regulator
AA2016_RS13015	COG2862	Uncharacterized protein family, UPF0114
AA2016_RS13025	COG2983	Belongs to the UPF0260 family
AA2016_RS13035	COG2968	Membrane
AA2016_RS13045	COG1760	l-serine dehydratase
AA2016_RS13050	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA2016_RS13050	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA2016_RS13055	COG0509	glycine decarboxylation via glycine cleavage system
AA2016_RS13060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_RS13070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AA2016_RS13075	COG0583	DNA-binding transcription factor activity
AA2016_RS13080	COG1309	transcriptional regulator
AA2016_RS13085	COG1744	ABC transporter substrate-binding protein PnrA-like
AA2016_RS13090	COG3845	ABC transporter
AA2016_RS13095	COG4603	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS13100	COG1079	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS13105	COG0010	Belongs to the arginase family
AA2016_RS13120	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS13125	COG1414	Transcriptional regulator
AA2016_RS13130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AA2016_RS13135	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AA2016_RS13150	COG1309	transcriptional regulator
AA2016_RS13155	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_RS13170	COG1609	Transcriptional regulator
AA2016_RS13170	COG2207	Transcriptional regulator
AA2016_RS13175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA2016_RS13190	COG1609	Transcriptional regulator
AA2016_RS13200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_RS13210	COG0765	amino acid transport
AA2016_RS13220	COG0010	Belongs to the arginase family
AA2016_RS13225	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_RS13260	COG3842	ATPase activity
AA2016_RS13265	COG1082	Xylose isomerase domain protein TIM barrel
AA2016_RS13285	COG2814	Major facilitator Superfamily
AA2016_RS13295	COG4608	Belongs to the ABC transporter superfamily
AA2016_RS13300	COG0444	Belongs to the ABC transporter superfamily
AA2016_RS13305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS13310	COG0601	transmembrane transport
AA2016_RS13315	COG0747	negative chemotaxis
AA2016_RS13330	COG1473	amidohydrolase
AA2016_RS13335	COG1473	amidohydrolase
AA2016_RS13340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_RS13345	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_RS13355	COG5383	Protein conserved in bacteria
AA2016_RS13365	COG1737	Transcriptional regulator
AA2016_RS13365	COG0837	glucose binding
AA2016_RS13370	COG0747	negative chemotaxis
AA2016_RS13375	COG0601	transmembrane transport
AA2016_RS13380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS13385	COG0444	Belongs to the ABC transporter superfamily
AA2016_RS13410	COG3706	GGDEF domain
AA2016_RS13425	COG0463	Glycosyl transferase, family 2
AA2016_RS13480	COG0367	asparagine synthase
AA2016_RS13490	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_RS13495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AA2016_RS13530	COG1902	pentaerythritol trinitrate reductase activity
AA2016_RS13550	COG0673	inositol 2-dehydrogenase activity
AA2016_RS13560	COG0589	response to stress
AA2016_RS13565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_RS13570	COG4597	amino acid ABC transporter
AA2016_RS13575	COG0765	amino acid transport
AA2016_RS13585	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AA2016_RS13590	COG4208	sulfate ABC transporter
AA2016_RS13595	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AA2016_RS13600	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AA2016_RS13620	COG4953	penicillin-binding protein 1C
AA2016_RS13630	COG0729	surface antigen
AA2016_RS13640	COG4166	transmembrane transport
AA2016_RS13645	COG0601	transmembrane transport
AA2016_RS13650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS13665	COG0493	'glutamate synthase
AA2016_RS13685	COG1959	2 iron, 2 sulfur cluster binding
AA2016_RS13690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AA2016_RS13720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_RS13725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_RS13750	COG0028	Belongs to the TPP enzyme family
AA2016_RS13755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA2016_RS13760	COG2267	carboxylic ester hydrolase activity
AA2016_RS13765	COG1131	(ABC) transporter
AA2016_RS13770	COG0842	Transport permease protein
AA2016_RS13795	COG4106	trans-aconitate 2-methyltransferase activity
AA2016_RS13810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AA2016_RS13815	COG1522	sequence-specific DNA binding
AA2016_RS13825	COG1720	tRNA m6t6A37 methyltransferase activity
AA2016_RS13850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AA2016_RS13885	COG0697	spore germination
AA2016_RS13890	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AA2016_RS13910	COG0626	cystathionine gamma-synthase activity
AA2016_RS13915	COG2001	Belongs to the MraZ family
AA2016_RS13920	COG0275	rRNA processing
AA2016_RS13935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AA2016_RS13945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AA2016_RS13950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AA2016_RS13960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AA2016_RS13965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AA2016_RS13970	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AA2016_RS13975	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA2016_RS13980	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AA2016_RS13985	COG0849	cell division
AA2016_RS13990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AA2016_RS14000	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA2016_RS14015	COG2176	DNA-directed DNA polymerase activity
AA2016_RS14030	COG0006	proline dipeptidase activity
AA2016_RS14035	COG2264	protein methyltransferase activity
AA2016_RS14040	COG1999	signal sequence binding
AA2016_RS14050	COG0110	maltose O-acetyltransferase activity
AA2016_RS14070	COG5002	protein histidine kinase activity
AA2016_RS14075	COG0745	RESPONSE REGULATOR receiver
AA2016_RS14090	COG0210	DNA helicase
AA2016_RS14115	COG0277	FAD linked oxidase domain protein
AA2016_RS14155	COG2814	Major facilitator Superfamily
AA2016_RS14160	COG3706	GGDEF domain
AA2016_RS14185	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AA2016_RS14200	COG0330	HflC and HflK could
AA2016_RS14205	COG0330	HflC and HflK could
AA2016_RS14215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA2016_RS14225	COG0560	Phosphoserine phosphatase
AA2016_RS14225	COG3830	Belongs to the UPF0237 family
AA2016_RS14230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AA2016_RS14240	COG2267	carboxylic ester hydrolase activity
AA2016_RS14250	COG1132	(ABC) transporter
AA2016_RS14255	COG0028	Belongs to the TPP enzyme family
AA2016_RS14260	COG0440	acetolactate synthase activity
AA2016_RS14310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AA2016_RS14330	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AA2016_RS14335	COG3158	transport of potassium into the cell
AA2016_RS14340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA2016_RS14360	COG0583	DNA-binding transcription factor activity
AA2016_RS14365	COG1309	transcriptional regulator
AA2016_RS14370	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AA2016_RS14400	COG1136	(ABC) transporter
AA2016_RS14400	COG0577	efflux transmembrane transporter activity
AA2016_RS14405	COG0577	efflux transmembrane transporter activity
AA2016_RS14405	COG1136	(ABC) transporter
AA2016_RS14415	COG0384	phenazine biosynthesis protein PhzF
AA2016_RS14435	COG0628	permease
AA2016_RS14450	COG1959	2 iron, 2 sulfur cluster binding
AA2016_RS14455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AA2016_RS14460	COG4208	sulfate ABC transporter
AA2016_RS14470	COG4150	thiosulfate binding
AA2016_RS14475	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AA2016_RS14480	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AA2016_RS14485	COG1797	cobyrinic acid a,c-diamide synthase activity
AA2016_RS14495	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AA2016_RS14555	COG3214	Protein conserved in bacteria
AA2016_RS14560	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA2016_RS14565	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA2016_RS14570	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA2016_RS14575	COG0649	NAD binding
AA2016_RS14580	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AA2016_RS14585	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AA2016_RS14590	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AA2016_RS14590	COG3743	rRNA binding
AA2016_RS14600	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AA2016_RS14605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA2016_RS14615	COG0713	ATP synthesis coupled electron transport
AA2016_RS14630	COG1007	ATP synthesis coupled electron transport
AA2016_RS14645	COG0346	lactoylglutathione lyase activity
AA2016_RS14655	COG0442	prolyl-tRNA aminoacylation
AA2016_RS14665	COG1136	(ABC) transporter
AA2016_RS14675	COG0321	lipoyl(octanoyl) transferase activity
AA2016_RS14700	COG0789	Transcriptional regulator
AA2016_RS14705	COG2239	Acts as a magnesium transporter
AA2016_RS14785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA2016_RS14815	COG0583	DNA-binding transcription factor activity
AA2016_RS14835	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA2016_RS14835	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_RS14845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_RS14850	COG3264	Mechanosensitive ion channel
AA2016_RS14850	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AA2016_RS14875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA2016_RS14945	COG0583	DNA-binding transcription factor activity
AA2016_RS14970	COG0646	methionine synthase
AA2016_RS14970	COG1410	methionine synthase
AA2016_RS14990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AA2016_RS14995	COG3932	Exopolysaccharide synthesis, ExoD
AA2016_RS15015	COG5012	cobalamin binding
AA2016_RS15020	COG5598	trimethylamine methyltransferase
AA2016_RS15030	COG2186	Transcriptional regulator
AA2016_RS15035	COG2807	transmembrane transport
AA2016_RS15045	COG2081	HI0933 family
AA2016_RS15060	COG2304	oxidoreductase activity
AA2016_RS15080	COG0646	methionine synthase
AA2016_RS15080	COG1410	methionine synthase
AA2016_RS15110	COG0006	proline dipeptidase activity
AA2016_RS15120	COG5598	trimethylamine methyltransferase
AA2016_RS15155	COG1960	acyl-CoA dehydrogenase activity
AA2016_RS15165	COG1492	cobalamin metabolic process
AA2016_RS15190	COG4172	Belongs to the ABC transporter superfamily
AA2016_RS15195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS15200	COG0601	transmembrane transport
AA2016_RS15205	COG0747	negative chemotaxis
AA2016_RS15210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA2016_RS15235	COG0243	molybdopterin cofactor binding
AA2016_RS15240	COG0437	4 iron, 4 sulfur cluster binding
AA2016_RS15245	COG3302	dmso reductase anchor subunit
AA2016_RS15250	COG1560	Kdo2-lipid A biosynthetic process
AA2016_RS15260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA2016_RS15265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA2016_RS15270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA2016_RS15300	COG1522	sequence-specific DNA binding
AA2016_RS15330	COG1629	transport
AA2016_RS15340	COG3720	iron ion transport
AA2016_RS15350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA2016_RS15355	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AA2016_RS15360	COG1959	2 iron, 2 sulfur cluster binding
AA2016_RS15375	COG1309	transcriptional regulator
AA2016_RS15385	COG2733	membrane
AA2016_RS15435	COG2832	Protein of unknown function (DUF454)
AA2016_RS15440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AA2016_RS15445	COG2205	protein histidine kinase activity
AA2016_RS15490	COG2205	protein histidine kinase activity
AA2016_RS15495	COG1525	nuclease
AA2016_RS15500	COG0625	glutathione transferase activity
AA2016_RS15505	COG1573	uracil-dna glycosylase
AA2016_RS15510	COG1522	sequence-specific DNA binding
AA2016_RS15520	COG2084	Dehydrogenase
AA2016_RS15540	COG1763	Mo-molybdopterin cofactor biosynthetic process
AA2016_RS15545	COG0746	molybdenum cofactor guanylyltransferase activity
AA2016_RS15565	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AA2016_RS15585	COG1846	Transcriptional regulator
AA2016_RS15590	COG0596	Alpha beta hydrolase
AA2016_RS15610	COG2989	Protein conserved in bacteria
AA2016_RS15630	COG0546	phosphoglycolate phosphatase activity
AA2016_RS15635	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AA2016_RS15650	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AA2016_RS15655	COG2199	diguanylate cyclase activity
AA2016_RS15660	COG2514	catechol 2,3-dioxygenase activity
AA2016_RS15670	COG0659	secondary active sulfate transmembrane transporter activity
AA2016_RS15675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AA2016_RS15700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA2016_RS15720	COG3608	succinylglutamate desuccinylase aspartoacylase
AA2016_RS15720	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AA2016_RS15725	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AA2016_RS15755	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA2016_RS15755	COG0596	Alpha beta hydrolase
AA2016_RS15790	COG0583	DNA-binding transcription factor activity
AA2016_RS15795	COG2855	membrane
AA2016_RS15820	COG0850	regulation of cytokinetic process
AA2016_RS15825	COG2894	cell division
AA2016_RS15830	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AA2016_RS15865	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_RS15870	COG1607	acyl-coa hydrolase
AA2016_RS15875	COG0251	oxidation-reduction process
AA2016_RS15895	COG0071	Belongs to the small heat shock protein (HSP20) family
AA2016_RS15945	COG0045	succinate-CoA ligase (ADP-forming) activity
AA2016_RS15945	COG1042	CoA-binding domain protein
AA2016_RS15945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA2016_RS15955	COG0459	protein refolding
AA2016_RS15970	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AA2016_RS15975	COG2235	arginine
AA2016_RS16005	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AA2016_RS16045	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AA2016_RS16085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA2016_RS16100	COG2205	protein histidine kinase activity
AA2016_RS16105	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA2016_RS16120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA2016_RS16130	COG0586	Pfam SNARE associated Golgi protein
AA2016_RS16145	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AA2016_RS16155	COG1136	(ABC) transporter
AA2016_RS16170	COG5622	Protein required for attachment to host cells
AA2016_RS16180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AA2016_RS16190	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AA2016_RS16200	COG1058	Belongs to the CinA family
AA2016_RS16200	COG1546	Belongs to the CinA family
AA2016_RS16210	COG0596	Alpha beta hydrolase
AA2016_RS16235	COG2267	carboxylic ester hydrolase activity
AA2016_RS16260	COG4191	Histidine kinase
AA2016_RS16265	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AA2016_RS16275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AA2016_RS16280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AA2016_RS16295	COG1278	Cold shock
AA2016_RS16315	COG1024	Enoyl-CoA hydratase
AA2016_RS16360	COG0517	IMP dehydrogenase activity
AA2016_RS16360	COG0516	GMP reductase activity
AA2016_RS16365	COG3811	Belongs to the UPF0386 family
AA2016_RS16370	COG5002	protein histidine kinase activity
AA2016_RS16370	COG3850	Histidine kinase
AA2016_RS16375	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA2016_RS16385	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AA2016_RS16390	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AA2016_RS16415	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AA2016_RS16420	COG0439	Biotin carboxylase
AA2016_RS16425	COG0511	ligase activity, forming carbon-carbon bonds
AA2016_RS16430	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AA2016_RS16445	COG0436	Aminotransferase
AA2016_RS16470	COG2066	Belongs to the glutaminase family
AA2016_RS16520	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AA2016_RS16535	COG0525	valine-tRNA ligase activity
AA2016_RS16550	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AA2016_RS16560	COG2233	PERMEase
AA2016_RS16580	COG0316	Belongs to the HesB IscA family
AA2016_RS16585	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AA2016_RS16590	COG0018	arginyl-trna synthetase
AA2016_RS16605	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AA2016_RS16610	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AA2016_RS16615	COG3842	ATPase activity
AA2016_RS16620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA2016_RS16625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA2016_RS16630	COG0805	protein transport
AA2016_RS16635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AA2016_RS16640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AA2016_RS16645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AA2016_RS16660	COG1862	Preprotein translocase
AA2016_RS16690	COG0519	Catalyzes the synthesis of GMP from XMP
AA2016_RS16695	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AA2016_RS16730	COG0544	peptidyl-prolyl cis-trans isomerase activity
AA2016_RS16735	COG2003	Belongs to the UPF0758 family
AA2016_RS16740	COG0024	Methionine aminopeptidase
AA2016_RS16750	COG2824	Alkylphosphonate utilization operon protein PhnA
AA2016_RS16755	COG1609	Transcriptional regulator
AA2016_RS16765	COG1175	transmembrane transport
AA2016_RS16770	COG0395	ABC-type sugar transport system, permease component
AA2016_RS16785	COG3842	ATPase activity
AA2016_RS16805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA2016_RS16810	COG1116	anion transmembrane transporter activity
AA2016_RS16815	COG4149	molybdate abc transporter
AA2016_RS16830	COG2197	response regulator
AA2016_RS16860	COG3243	poly(R)-hydroxyalkanoic acid synthase
AA2016_RS16870	COG0436	Aminotransferase
AA2016_RS16880	COG1494	fructose-1,6-bisphosphatase
AA2016_RS16885	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AA2016_RS16890	COG1752	Esterase of the alpha-beta hydrolase superfamily
AA2016_RS16895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AA2016_RS16900	COG0302	gtp cyclohydrolase
AA2016_RS16910	COG0583	DNA-binding transcription factor activity
AA2016_RS16915	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AA2016_RS16925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AA2016_RS16940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA2016_RS16945	COG2301	Belongs to the HpcH HpaI aldolase family
AA2016_RS16960	COG0187	DNA topoisomerase II activity
AA2016_RS16975	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA2016_RS16975	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA2016_RS16980	COG0509	glycine decarboxylation via glycine cleavage system
AA2016_RS16985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_RS16995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AA2016_RS17010	COG1671	Belongs to the UPF0178 family
AA2016_RS17020	COG2153	protein acetylation
AA2016_RS17025	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AA2016_RS17040	COG3795	YCII-related domain
AA2016_RS17055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AA2016_RS17070	COG0475	glutathione-regulated potassium exporter activity
AA2016_RS17070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA2016_RS17085	COG3768	UPF0283 membrane protein
AA2016_RS17090	COG3106	COG3106 Predicted ATPase
AA2016_RS17125	COG0513	Belongs to the DEAD box helicase family
AA2016_RS17135	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS17145	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AA2016_RS17150	COG2897	thiosulfate sulfurtransferase activity
AA2016_RS17165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AA2016_RS17180	COG0686	Belongs to the AlaDH PNT family
AA2016_RS17185	COG1522	sequence-specific DNA binding
AA2016_RS17190	COG0737	Belongs to the 5'-nucleotidase family
AA2016_RS17200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA2016_RS17210	COG4957	zinc ion binding
AA2016_RS17215	COG1530	ribonuclease E activity
AA2016_RS17220	COG0860	N-Acetylmuramoyl-L-alanine amidase
AA2016_RS17225	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AA2016_RS17250	COG2885	chlorophyll binding
AA2016_RS17255	COG0513	Belongs to the DEAD box helicase family
AA2016_RS17260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AA2016_RS17270	COG3706	GGDEF domain
AA2016_RS17280	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AA2016_RS17290	COG1414	Transcriptional regulator
AA2016_RS17295	COG3960	tartronate-semialdehyde synthase activity
AA2016_RS17300	COG3622	Belongs to the hyi family
AA2016_RS17305	COG2084	Dehydrogenase
AA2016_RS17320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA2016_RS17335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AA2016_RS17360	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AA2016_RS17370	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AA2016_RS17375	COG0081	regulation of translation
AA2016_RS17380	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AA2016_RS17385	COG0222	ribosome binding
AA2016_RS17390	COG0085	RNA polymerase activity
AA2016_RS17395	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AA2016_RS17405	COG0531	amino acid
AA2016_RS17415	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AA2016_RS17420	COG0049	tRNA binding
AA2016_RS17425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA2016_RS17430	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AA2016_RS17435	COG0051	transcription antitermination factor activity, RNA binding
AA2016_RS17440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AA2016_RS17445	COG0088	Forms part of the polypeptide exit tunnel
AA2016_RS17450	COG0089	rRNA binding
AA2016_RS17455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AA2016_RS17460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AA2016_RS17465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AA2016_RS17470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AA2016_RS17475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AA2016_RS17480	COG0255	Belongs to the universal ribosomal protein uL29 family
AA2016_RS17485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AA2016_RS17490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AA2016_RS17495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AA2016_RS17500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AA2016_RS17505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AA2016_RS17510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AA2016_RS17515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AA2016_RS17520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AA2016_RS17525	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AA2016_RS17530	COG1841	ribosomal large subunit assembly
AA2016_RS17535	COG0200	Binds to the 23S rRNA
AA2016_RS17545	COG0563	adenylate kinase activity
AA2016_RS17550	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AA2016_RS17555	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AA2016_RS17560	COG0202	RNA polymerase activity
AA2016_RS17565	COG0203	ribosomal protein L17
AA2016_RS17575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AA2016_RS17580	COG0640	Transcriptional regulator
AA2016_RS17610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AA2016_RS17610	COG0321	lipoyl(octanoyl) transferase activity
AA2016_RS17615	COG0084	hydrolase, TatD family'
AA2016_RS17630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AA2016_RS17635	COG1686	Belongs to the peptidase S11 family
AA2016_RS17690	COG1278	Cold shock
AA2016_RS17695	COG5490	Phasin protein
AA2016_RS17700	COG1475	DNA binding
AA2016_RS17830	COG0708	Exodeoxyribonuclease III
AA2016_RS17845	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AA2016_RS17860	COG0583	DNA-binding transcription factor activity
AA2016_RS17865	COG0601	transmembrane transport
AA2016_RS17870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS17875	COG0444	Belongs to the ABC transporter superfamily
AA2016_RS17880	COG4608	Belongs to the ABC transporter superfamily
AA2016_RS17885	COG4166	transmembrane transport
AA2016_RS18045	COG0739	heme binding
AA2016_RS18055	COG0861	Integral membrane protein TerC family
AA2016_RS18060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA2016_RS18065	COG2814	Major facilitator Superfamily
AA2016_RS18100	COG1024	Enoyl-CoA hydratase
AA2016_RS18110	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS18120	COG1960	acyl-CoA dehydrogenase activity
AA2016_RS18130	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS18135	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS18150	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS18170	COG0183	Belongs to the thiolase family
AA2016_RS18175	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS18185	COG1960	acyl-CoA dehydrogenase activity
AA2016_RS18200	COG1024	Enoyl-CoA hydratase
AA2016_RS18200	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA2016_RS18205	COG0604	alcohol dehydrogenase
AA2016_RS18210	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS18215	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_RS18265	COG0657	acetylesterase activity
AA2016_RS18275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA2016_RS18280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA2016_RS18300	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS18305	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AA2016_RS18310	COG0183	Belongs to the thiolase family
AA2016_RS18315	COG1960	acyl-CoA dehydrogenase activity
AA2016_RS18320	COG1960	acyl-CoA dehydrogenase activity
AA2016_RS18325	COG1024	Enoyl-CoA hydratase
AA2016_RS18330	COG0667	Aldo Keto reductase
AA2016_RS18335	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AA2016_RS18370	COG2801	Transposase and inactivated derivatives
AA2016_RS18380	COG1079	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS18385	COG4603	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS18390	COG3845	ABC transporter
AA2016_RS18400	COG1183	phosphatidylcholine synthase activity
AA2016_RS18405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA2016_RS18410	COG0679	Auxin Efflux Carrier
AA2016_RS18425	COG4166	transmembrane transport
AA2016_RS18440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AA2016_RS18445	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AA2016_RS18450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AA2016_RS18460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AA2016_RS18465	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AA2016_RS18470	COG0785	Cytochrome C biogenesis protein
AA2016_RS18500	COG0861	Integral membrane protein TerC family
AA2016_RS18525	COG2308	Evidence 4 Homologs of previously reported genes of
AA2016_RS18540	COG0488	(ABC) transporter
AA2016_RS18555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AA2016_RS18560	COG0343	queuine tRNA-ribosyltransferase activity
AA2016_RS18565	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AA2016_RS18585	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AA2016_RS18590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AA2016_RS18595	COG2095	MarC family integral membrane protein
AA2016_RS18610	COG0629	single-stranded DNA binding
AA2016_RS18620	COG2188	Transcriptional regulator
AA2016_RS18625	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AA2016_RS18625	COG1940	carbohydrate kinase activity
AA2016_RS18630	COG0395	ABC-type sugar transport system, permease component
AA2016_RS18650	COG4948	Mandelate Racemase Muconate Lactonizing
AA2016_RS18660	COG1794	racemase activity, acting on amino acids and derivatives
AA2016_RS18665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AA2016_RS18685	COG1309	transcriptional regulator
AA2016_RS18690	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS18695	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AA2016_RS18695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AA2016_RS18700	COG0347	Belongs to the P(II) protein family
AA2016_RS18705	COG0174	glutamine synthetase
AA2016_RS18715	COG2801	Transposase and inactivated derivatives
AA2016_RS18740	COG0174	glutamine synthetase
AA2016_RS18750	COG0697	spore germination
AA2016_RS18765	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AA2016_RS18770	COG3956	TIGRFAM MazG family protein
AA2016_RS18775	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AA2016_RS18780	COG1923	regulation of RNA biosynthetic process
AA2016_RS18785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AA2016_RS18790	COG0569	domain protein
AA2016_RS18795	COG2204	response regulator
AA2016_RS18800	COG5000	phosphorelay sensor kinase activity
AA2016_RS18805	COG2204	response regulator
AA2016_RS18810	COG3852	Histidine kinase
AA2016_RS18820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AA2016_RS18820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AA2016_RS18825	COG1058	Belongs to the CinA family
AA2016_RS18825	COG1546	Belongs to the CinA family
AA2016_RS18835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AA2016_RS18845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA2016_RS18850	COG0456	acetyltransferase
AA2016_RS18850	COG1214	PFAM Peptidase M22, glycoprotease
AA2016_RS18860	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA2016_RS18865	COG0022	dehydrogenase e1 component
AA2016_RS18865	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA2016_RS18870	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AA2016_RS18875	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AA2016_RS18880	COG0148	phosphopyruvate hydratase activity
AA2016_RS18895	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AA2016_RS18910	COG0504	CTP synthase activity
AA2016_RS18925	COG0149	triose-phosphate isomerase activity
AA2016_RS18935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AA2016_RS18940	COG0134	indole-3-glycerol-phosphate synthase activity
AA2016_RS18945	COG0315	cyclic pyranopterin monophosphate synthase activity
AA2016_RS18950	COG0303	'Molybdopterin
AA2016_RS18955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AA2016_RS18965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA2016_RS18970	COG0372	Belongs to the citrate synthase family
AA2016_RS18975	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA2016_RS18985	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA2016_RS18990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AA2016_RS18995	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA2016_RS19000	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA2016_RS19005	COG0750	zinc metalloprotease
AA2016_RS19015	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AA2016_RS19020	COG0233	cytoplasmic translational termination
AA2016_RS19025	COG0528	UMP kinase activity
AA2016_RS19030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AA2016_RS19035	COG0052	Belongs to the universal ribosomal protein uS2 family
AA2016_RS19070	COG0537	adenosine 5'-monophosphoramidase activity
AA2016_RS19100	COG3706	GGDEF domain
AA2016_RS19110	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AA2016_RS19120	COG1686	Belongs to the peptidase S11 family
AA2016_RS19125	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AA2016_RS19140	COG1760	l-serine dehydratase
AA2016_RS19150	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AA2016_RS19155	COG0154	amidase activity
AA2016_RS19160	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA2016_RS19170	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA2016_RS19175	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AA2016_RS19185	COG1960	acyl-CoA dehydrogenase activity
AA2016_RS19190	COG0540	Belongs to the ATCase OTCase family
AA2016_RS19195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA2016_RS19200	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AA2016_RS19205	COG0758	DNA mediated transformation
AA2016_RS19210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AA2016_RS19215	COG0557	exoribonuclease II activity
AA2016_RS19235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AA2016_RS19245	COG0784	Response regulator, receiver
AA2016_RS19260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AA2016_RS19265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AA2016_RS19270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AA2016_RS19280	COG0492	ferredoxin-NADP+ reductase activity
AA2016_RS19285	COG0633	Ferredoxin
AA2016_RS19300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AA2016_RS19300	COG3218	ABC-type transport auxiliary lipoprotein component
AA2016_RS19310	COG1127	ABC transporter
AA2016_RS19320	COG4948	Mandelate Racemase Muconate Lactonizing
AA2016_RS19335	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS19340	COG0280	phosphate acetyltransferase
AA2016_RS19340	COG0281	malic enzyme
AA2016_RS19350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA2016_RS19355	COG5265	(ABC) transporter
AA2016_RS19360	COG0640	Transcriptional regulator
AA2016_RS19370	COG0740	serine-type endopeptidase activity
AA2016_RS19410	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AA2016_RS19415	COG3384	dioxygenase
AA2016_RS19425	COG0519	Catalyzes the synthesis of GMP from XMP
AA2016_RS19445	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AA2016_RS19450	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AA2016_RS19455	COG0047	phosphoribosylformylglycinamidine synthase activity
AA2016_RS19470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA2016_RS19475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AA2016_RS19485	COG2226	methyltransferase
AA2016_RS19495	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AA2016_RS19500	COG2814	Major facilitator Superfamily
AA2016_RS19505	COG0037	tRNA processing
AA2016_RS19510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AA2016_RS19520	COG1733	regulation of RNA biosynthetic process
AA2016_RS19525	COG0702	epimerase
AA2016_RS19535	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AA2016_RS19550	COG0538	isocitrate dehydrogenase activity
AA2016_RS19565	COG0346	lactoylglutathione lyase activity
AA2016_RS19570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AA2016_RS19575	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AA2016_RS19585	COG2313	pseudouridylate synthase activity
AA2016_RS19600	COG0316	Belongs to the HesB IscA family
AA2016_RS19615	COG2151	metal-sulfur cluster biosynthetic enzyme
AA2016_RS19620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA2016_RS19625	COG0719	Fe-S assembly protein
AA2016_RS19630	COG0396	ATPase activity
AA2016_RS19635	COG0719	Fe-S assembly protein
AA2016_RS19645	COG2945	thiolester hydrolase activity
AA2016_RS19675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AA2016_RS19685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA2016_RS19690	COG0739	heme binding
AA2016_RS19730	COG0405	Gamma-glutamyltransferase
AA2016_RS19735	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS19740	COG1129	ABC transporter
AA2016_RS19760	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AA2016_RS19765	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_RS19780	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AA2016_RS19790	COG0411	ABC transporter
AA2016_RS19800	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS19820	COG1917	Cupin 2, conserved barrel domain protein
AA2016_RS19825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2016_RS19835	COG0583	DNA-binding transcription factor activity
AA2016_RS19855	COG0583	DNA-binding transcription factor activity
AA2016_RS19875	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AA2016_RS19885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AA2016_RS19890	COG0156	8-amino-7-oxononanoate synthase activity
AA2016_RS19900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AA2016_RS19905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA2016_RS19920	COG4608	Belongs to the ABC transporter superfamily
AA2016_RS19925	COG0444	Belongs to the ABC transporter superfamily
AA2016_RS19930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS19935	COG0601	transmembrane transport
AA2016_RS19940	COG1396	sequence-specific DNA binding
AA2016_RS19945	COG0747	negative chemotaxis
AA2016_RS19960	COG0776	regulation of translation
AA2016_RS19970	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AA2016_RS19975	COG0740	serine-type endopeptidase activity
AA2016_RS20020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AA2016_RS20025	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AA2016_RS20035	COG0584	glycerophosphoryl diester phosphodiesterase
AA2016_RS20040	COG0010	Belongs to the arginase family
AA2016_RS20055	COG1612	heme a metabolic process
AA2016_RS20085	COG0297	glycogen (starch) synthase activity
AA2016_RS20120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AA2016_RS20135	COG0776	regulation of translation
AA2016_RS20140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA2016_RS20145	COG0416	fatty acid biosynthetic process
AA2016_RS20160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA2016_RS20165	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AA2016_RS20180	COG1174	glycine betaine transport
AA2016_RS20185	COG1125	glycine betaine transport
AA2016_RS20190	COG1174	glycine betaine transport
AA2016_RS20195	COG1732	Glycine betaine
AA2016_RS20200	COG2814	Major facilitator Superfamily
AA2016_RS20205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA2016_RS20210	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AA2016_RS20220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA2016_RS20220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA2016_RS20225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AA2016_RS20230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AA2016_RS20240	COG2989	Protein conserved in bacteria
AA2016_RS20260	COG0113	porphobilinogen synthase activity
AA2016_RS20270	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AA2016_RS20280	COG0628	permease
AA2016_RS20285	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AA2016_RS20295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AA2016_RS20310	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AA2016_RS20330	COG0477	Major facilitator Superfamily
AA2016_RS20335	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AA2016_RS20375	COG1079	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS20380	COG4603	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS20385	COG3845	ABC transporter
AA2016_RS20425	COG1079	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS20430	COG4603	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS20435	COG3845	ABC transporter
AA2016_RS20445	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_RS20455	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA2016_RS20480	COG0730	response to heat
AA2016_RS20490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA2016_RS20500	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_RS20505	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AA2016_RS20510	COG1349	DNA-binding transcription factor activity
AA2016_RS20525	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA2016_RS20530	COG0583	DNA-binding transcription factor activity
AA2016_RS20540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_RS20545	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AA2016_RS20550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA2016_RS20555	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA2016_RS20560	COG2188	Transcriptional regulator
AA2016_RS20570	COG1116	anion transmembrane transporter activity
AA2016_RS20585	COG0583	DNA-binding transcription factor activity
AA2016_RS20590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AA2016_RS20610	COG1940	carbohydrate kinase activity
AA2016_RS20610	COG1846	Transcriptional regulator
AA2016_RS20615	COG1653	transport
AA2016_RS20645	COG2252	PERMEase
AA2016_RS20660	COG3842	ATPase activity
AA2016_RS20670	COG0395	ABC-type sugar transport system, permease component
AA2016_RS20685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AA2016_RS20695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AA2016_RS20700	COG1132	(ABC) transporter
AA2016_RS20705	COG3459	Glycosyltransferase 36 associated
AA2016_RS20720	COG3314	Sporulation integral membrane protein YlbJ
AA2016_RS20725	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AA2016_RS20735	COG2986	histidine ammonia-lyase
AA2016_RS20740	COG1228	amidohydrolase
AA2016_RS20765	COG0251	oxidation-reduction process
AA2016_RS20775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AA2016_RS20780	COG0803	Belongs to the bacterial solute-binding protein 9 family
AA2016_RS20810	COG1234	tRNA 3'-trailer cleavage
AA2016_RS20820	COG1063	alcohol dehydrogenase
AA2016_RS20835	COG4948	Mandelate Racemase Muconate Lactonizing
AA2016_RS20845	COG1960	acyl-CoA dehydrogenase activity
AA2016_RS20855	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA2016_RS20855	COG1902	pentaerythritol trinitrate reductase activity
AA2016_RS20860	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AA2016_RS20875	COG5598	trimethylamine methyltransferase
AA2016_RS20880	COG0583	DNA-binding transcription factor activity
AA2016_RS20885	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AA2016_RS20905	COG1663	tetraacyldisaccharide 4'-kinase activity
AA2016_RS20910	COG1519	Transferase
AA2016_RS20925	COG0483	inositol monophosphate 1-phosphatase activity
AA2016_RS20930	COG0312	modulator of DNA gyrase
AA2016_RS20945	COG0612	Peptidase, M16
AA2016_RS20950	COG0612	Peptidase, M16
AA2016_RS20955	COG0742	ribosomal rna small subunit methyltransferase
AA2016_RS20965	COG0590	tRNA wobble adenosine to inosine editing
AA2016_RS20975	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AA2016_RS20990	COG0196	riboflavin kinase activity
AA2016_RS21005	COG2814	Major facilitator Superfamily
AA2016_RS21015	COG1846	Transcriptional regulator
AA2016_RS21020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA2016_RS21020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA2016_RS21030	COG0459	protein refolding
AA2016_RS21055	COG3237	CsbD-like
AA2016_RS21070	COG0114	fumarate hydratase activity
AA2016_RS21075	COG2259	Doxx family
AA2016_RS21080	COG2801	Transposase and inactivated derivatives
AA2016_RS21095	COG0248	Ppx GppA phosphatase
AA2016_RS21100	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AA2016_RS21110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA2016_RS21120	COG1126	abc transporter atp-binding protein
AA2016_RS21125	COG0765	amino acid transport
AA2016_RS21130	COG4597	amino acid ABC transporter
AA2016_RS21135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_RS21145	COG0626	cystathionine gamma-synthase activity
AA2016_RS21170	COG3852	Histidine kinase
AA2016_RS21200	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AA2016_RS21210	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AA2016_RS21340	COG0601	transmembrane transport
AA2016_RS21345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS21350	COG0444	Belongs to the ABC transporter superfamily
AA2016_RS21365	COG2207	Transcriptional regulator
AA2016_RS21385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AA2016_RS21395	COG5425	PFAM Usg family protein
AA2016_RS21405	COG0071	Belongs to the small heat shock protein (HSP20) family
AA2016_RS21410	COG0071	Belongs to the small heat shock protein (HSP20) family
AA2016_RS21415	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AA2016_RS21425	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AA2016_RS21480	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS21485	COG1129	ABC transporter
AA2016_RS21490	COG0702	epimerase
AA2016_RS21500	COG2186	Transcriptional regulator
AA2016_RS21515	COG2186	Transcriptional regulator
AA2016_RS21525	COG1136	(ABC) transporter
AA2016_RS21630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2016_RS21645	COG3265	gluconokinase activity
AA2016_RS21650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AA2016_RS21660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AA2016_RS21665	COG2084	Dehydrogenase
AA2016_RS21740	COG0444	Belongs to the ABC transporter superfamily
AA2016_RS21745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2016_RS21760	COG0747	negative chemotaxis
AA2016_RS21765	COG2186	Transcriptional regulator
AA2016_RS21785	COG1473	amidohydrolase
AA2016_RS21790	COG3474	cytochrome
AA2016_RS21905	COG0210	DNA helicase
AA2016_RS21945	COG0640	Transcriptional regulator
AA2016_RS21950	COG0798	PFAM Bile acid sodium symporter
AA2016_RS21960	COG0431	NADPH-dependent FMN reductase
AA2016_RS21980	COG0753	catalase activity
AA2016_RS22020	COG1278	Cold shock
AA2016_RS22025	COG3685	Protein conserved in bacteria
AA2016_RS22035	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS22085	COG2827	Endonuclease containing a URI domain
AA2016_RS22125	COG2827	Endonuclease containing a URI domain
AA2016_RS22130	COG2205	protein histidine kinase activity
AA2016_RS22130	COG2198	Histidine kinase
AA2016_RS22130	COG0784	Response regulator, receiver
AA2016_RS22135	COG2197	response regulator
AA2016_RS22140	COG1280	lysine exporter protein (LysE YggA)
AA2016_RS22155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS22165	COG0747	negative chemotaxis
AA2016_RS22190	COG2827	Endonuclease containing a URI domain
AA2016_RS22205	COG0628	permease
AA2016_RS22210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AA2016_RS22215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AA2016_RS22220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AA2016_RS22260	COG0583	DNA-binding transcription factor activity
AA2016_RS22305	COG0583	DNA-binding transcription factor activity
AA2016_RS22310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_RS22315	COG0765	amino acid transport
AA2016_RS22325	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AA2016_RS22340	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AA2016_RS22375	COG0243	molybdopterin cofactor binding
AA2016_RS22380	COG0488	(ABC) transporter
AA2016_RS22385	COG2211	Major facilitator Superfamily
AA2016_RS22405	COG0105	UTP biosynthetic process
AA2016_RS22420	COG0314	molybdopterin synthase activity
AA2016_RS22435	COG0322	excinuclease ABC activity
AA2016_RS22495	COG0625	glutathione transferase activity
AA2016_RS22510	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AA2016_RS22545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AA2016_RS22570	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AA2016_RS22575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AA2016_RS22580	COG0194	GDP metabolic process
AA2016_RS22585	COG1561	YicC-like family, N-terminal region
AA2016_RS22590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AA2016_RS22595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA2016_RS22600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA2016_RS22610	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AA2016_RS22615	COG1368	sulfuric ester hydrolase activity
AA2016_RS22620	COG0360	Binds together with S18 to 16S ribosomal RNA
AA2016_RS22630	COG0359	binds to the 23S rRNA
AA2016_RS22635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA2016_RS22640	COG1742	UPF0060 membrane protein
AA2016_RS22645	COG3468	outer membrane autotransporter barrel domain protein
AA2016_RS22650	COG0305	Participates in initiation and elongation during chromosome replication
AA2016_RS22665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AA2016_RS22675	COG4221	oxidoreductase activity
AA2016_RS22680	COG3273	potassium ion transport
AA2016_RS22680	COG0471	metal ion transport
AA2016_RS22710	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_RS22710	COG0204	Acyl-transferase
AA2016_RS22720	COG0688	phosphatidylethanolamine metabolic process
AA2016_RS22725	COG5265	(ABC) transporter
AA2016_RS22735	COG1652	LysM domain
AA2016_RS22750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA2016_RS22780	COG2852	Protein conserved in bacteria
AA2016_RS22790	COG0215	cysteine-tRNA ligase activity
AA2016_RS22805	COG0494	nUDIX hydrolase
AA2016_RS22825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA2016_RS22835	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AA2016_RS22860	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS22870	COG0640	Transcriptional regulator
AA2016_RS22930	COG1381	Involved in DNA repair and RecF pathway recombination
AA2016_RS22935	COG0477	Major facilitator Superfamily
AA2016_RS22955	COG2814	Major facilitator Superfamily
AA2016_RS22975	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_RS23005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA2016_RS23015	COG1280	lysine exporter protein (LysE YggA)
AA2016_RS23035	COG2814	Major facilitator Superfamily
AA2016_RS23050	COG0300	oxidoreductase activity
AA2016_RS23065	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AA2016_RS23070	COG0571	ribonuclease III activity
AA2016_RS23075	COG0681	Belongs to the peptidase S26 family
AA2016_RS23080	COG0736	holo-[acyl-carrier-protein] synthase activity
AA2016_RS23085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AA2016_RS23095	COG1758	RNA polymerase activity
AA2016_RS23115	COG2827	Endonuclease containing a URI domain
AA2016_RS23120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AA2016_RS23125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2016_RS23130	COG0741	lytic transglycosylase activity
AA2016_RS23155	COG4974	Belongs to the 'phage' integrase family
AA2016_RS23170	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
AA2016_RS23175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA2016_RS23185	COG1960	acyl-CoA dehydrogenase activity
AA2016_RS23205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA2016_RS23210	COG4770	biotin carboxylase activity
AA2016_RS23220	COG0450	alkyl hydroperoxide reductase
AA2016_RS23240	COG0625	glutathione transferase activity
AA2016_RS23250	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA2016_RS23280	COG1573	uracil-dna glycosylase
AA2016_RS23295	COG0438	transferase activity, transferring glycosyl groups
AA2016_RS23310	COG0308	aminopeptidase N
AA2016_RS23315	COG2205	protein histidine kinase activity
AA2016_RS23315	COG2202	Pas domain
AA2016_RS23320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA2016_RS23330	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AA2016_RS23335	COG2205	protein histidine kinase activity
AA2016_RS23340	COG0745	RESPONSE REGULATOR receiver
AA2016_RS23345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA2016_RS23350	COG3088	subunit of a heme lyase
AA2016_RS23355	COG1138	Cytochrome C-type biogenesis protein
AA2016_RS23360	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AA2016_RS23365	COG4235	cytochrome complex assembly
AA2016_RS23390	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AA2016_RS23425	COG2205	protein histidine kinase activity
AA2016_RS23435	COG2166	iron-sulfur cluster assembly
AA2016_RS23440	COG4957	zinc ion binding
AA2016_RS23445	COG1320	monovalent cation:proton antiporter activity
AA2016_RS23450	COG2212	antiporter activity
AA2016_RS23455	COG1863	multisubunit Na H antiporter MnhE subunit
AA2016_RS23460	COG0651	ATP synthesis coupled electron transport
AA2016_RS23465	COG1006	Multisubunit Na H antiporter MnhC subunit
AA2016_RS23470	COG2111	Na H antiporter
AA2016_RS23475	COG2111	Na H antiporter
AA2016_RS23475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AA2016_RS23490	COG2010	Cytochrome c
AA2016_RS23495	COG3909	cytochrome
AA2016_RS23500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AA2016_RS23505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AA2016_RS23515	COG1376	ErfK ybiS ycfS ynhG family protein
AA2016_RS23520	COG0433	COG0433 Predicted ATPase
AA2016_RS23525	COG2336	PFAM SpoVT AbrB
AA2016_RS23530	COG3654	unkown
AA2016_RS23535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA2016_RS23545	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS23550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA2016_RS23555	COG1309	transcriptional regulator
AA2016_RS23560	COG3119	arylsulfatase activity
AA2016_RS23570	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AA2016_RS23575	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_RS23585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA2016_RS23605	COG4172	Belongs to the ABC transporter superfamily
AA2016_RS23610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS23615	COG0601	transmembrane transport
AA2016_RS23625	COG0366	Alpha amylase catalytic
AA2016_RS23630	COG1523	belongs to the glycosyl hydrolase 13 family
AA2016_RS23635	COG0033	Phosphoglucomutase
AA2016_RS23640	COG0297	glycogen (starch) synthase activity
AA2016_RS23645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AA2016_RS23650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AA2016_RS23655	COG0058	SHG alpha-glucan phosphorylase activity
AA2016_RS23675	COG1940	carbohydrate kinase activity
AA2016_RS23695	COG1218	3'(2'),5'-bisphosphate nucleotidase
AA2016_RS23705	COG0175	sulfate reduction
AA2016_RS23750	COG3685	Protein conserved in bacteria
AA2016_RS23780	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_RS23795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA2016_RS23795	COG0574	Belongs to the PEP-utilizing enzyme family
AA2016_RS23815	COG0583	DNA-binding transcription factor activity
AA2016_RS23820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AA2016_RS23825	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA2016_RS23835	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA2016_RS23835	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA2016_RS23845	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_RS23860	COG0183	Belongs to the thiolase family
AA2016_RS23870	COG0454	-acetyltransferase
AA2016_RS23875	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AA2016_RS23885	COG4172	Belongs to the ABC transporter superfamily
AA2016_RS23890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS23900	COG0747	negative chemotaxis
AA2016_RS23905	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AA2016_RS23910	COG2971	BadF BadG BcrA BcrD
AA2016_RS23915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AA2016_RS23920	COG1737	Transcriptional regulator
AA2016_RS23925	COG0243	molybdopterin cofactor binding
AA2016_RS23935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA2016_RS23945	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA2016_RS23950	COG3707	response regulator
AA2016_RS23955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA2016_RS23960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA2016_RS23975	COG1196	nuclear chromosome segregation
AA2016_RS23990	COG1194	a g-specific adenine glycosylase
AA2016_RS23995	COG1011	Hydrolase
AA2016_RS24000	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AA2016_RS24005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA2016_RS24025	COG0583	DNA-binding transcription factor activity
AA2016_RS24030	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AA2016_RS24045	COG0612	Peptidase, M16
AA2016_RS24050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA2016_RS24060	COG1678	Uncharacterized ACR, COG1678
AA2016_RS24070	COG0678	peroxiredoxin activity
AA2016_RS24075	COG0328	RNA-DNA hybrid ribonuclease activity
AA2016_RS24080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AA2016_RS24085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AA2016_RS24090	COG3346	SURF1 family
AA2016_RS24110	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AA2016_RS24115	COG0109	protoheme IX farnesyltransferase activity
AA2016_RS24120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA2016_RS24125	COG1565	acr, cog1565
AA2016_RS24125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA2016_RS24135	COG0312	modulator of DNA gyrase
AA2016_RS24140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AA2016_RS24145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AA2016_RS24155	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AA2016_RS24160	COG1741	Belongs to the pirin family
AA2016_RS24175	COG1733	regulation of RNA biosynthetic process
AA2016_RS24180	COG1722	exodeoxyribonuclease VII activity
AA2016_RS24185	COG0123	including yeast histone deacetylase and acetoin utilization protein
AA2016_RS24190	COG1309	transcriptional regulator
AA2016_RS24210	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA2016_RS24210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA2016_RS24215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AA2016_RS24225	COG0406	alpha-ribazole phosphatase activity
AA2016_RS24230	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AA2016_RS24235	COG0484	heat shock protein binding
AA2016_RS24245	COG0259	pyridoxamine-phosphate oxidase activity
AA2016_RS24250	COG1024	Enoyl-CoA hydratase
AA2016_RS24255	COG1960	acyl-CoA dehydrogenase activity
AA2016_RS24270	COG0151	Belongs to the GarS family
AA2016_RS24290	COG0009	L-threonylcarbamoyladenylate synthase
AA2016_RS24305	COG0751	glycine-tRNA ligase activity
AA2016_RS24310	COG0752	glycyl-tRNA synthetase alpha subunit
AA2016_RS24320	COG0142	geranyltranstransferase activity
AA2016_RS24345	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AA2016_RS24350	COG0521	Mo-molybdopterin cofactor biosynthetic process
AA2016_RS24365	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AA2016_RS24375	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AA2016_RS24380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AA2016_RS24385	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AA2016_RS24390	COG0356	it plays a direct role in the translocation of protons across the membrane
AA2016_RS24405	COG1160	GTP binding
AA2016_RS24420	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AA2016_RS24425	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AA2016_RS24435	COG0583	DNA-binding transcription factor activity
AA2016_RS24440	COG1393	Belongs to the ArsC family
AA2016_RS24445	COG0251	oxidation-reduction process
AA2016_RS24455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA2016_RS24475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA2016_RS24485	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_RS24500	COG0494	nUDIX hydrolase
AA2016_RS24505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_RS24525	COG0477	Major facilitator Superfamily
AA2016_RS24530	COG0583	DNA-binding transcription factor activity
AA2016_RS24535	COG0242	peptide deformylase activity
AA2016_RS24560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS24565	COG0601	transmembrane transport
AA2016_RS24610	COG0840	transmembrane signaling receptor activity
AA2016_RS24615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2016_RS24625	COG3386	PFAM SMP-30 Gluconolaconase
AA2016_RS24630	COG0800	Aldolase
AA2016_RS24635	COG3734	2-keto-3-deoxy-galactonokinase
AA2016_RS24640	COG1028	Short-chain dehydrogenase reductase Sdr
AA2016_RS24645	COG2017	converts alpha-aldose to the beta-anomer
AA2016_RS24655	COG1129	ABC transporter
AA2016_RS24665	COG2186	Transcriptional regulator
AA2016_RS24670	COG4948	Mandelate Racemase Muconate Lactonizing
AA2016_RS24690	COG4603	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS24695	COG1079	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS24700	COG3845	ABC transporter
AA2016_RS24710	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AA2016_RS24715	COG0163	prenyltransferase activity
AA2016_RS24735	COG0523	cobalamin synthesis protein
AA2016_RS24740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AA2016_RS24755	COG2233	PERMEase
AA2016_RS24760	COG0583	DNA-binding transcription factor activity
AA2016_RS24775	COG0431	NADPH-dependent FMN reductase
AA2016_RS24800	COG1396	sequence-specific DNA binding
AA2016_RS24815	COG3177	Filamentation induced by cAMP protein fic
AA2016_RS24835	COG1959	2 iron, 2 sulfur cluster binding
AA2016_RS24840	COG2346	COG2346, Truncated hemoglobins
AA2016_RS24860	COG3278	Belongs to the heme-copper respiratory oxidase family
AA2016_RS24875	COG2010	Cytochrome c
AA2016_RS24915	COG0583	DNA-binding transcription factor activity
AA2016_RS24925	COG0640	Transcriptional regulator
AA2016_RS24995	COG1525	nuclease
AA2016_RS25010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA2016_RS25025	COG2832	Protein of unknown function (DUF454)
AA2016_RS25035	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AA2016_RS25050	COG0826	peptidase U32
AA2016_RS25060	COG0521	Mo-molybdopterin cofactor biosynthetic process
AA2016_RS25070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AA2016_RS25075	COG2186	Transcriptional regulator
AA2016_RS25105	COG2151	metal-sulfur cluster biosynthetic enzyme
AA2016_RS25170	COG3794	PFAM blue (type 1) copper domain protein
AA2016_RS25210	COG3005	denitrification pathway
AA2016_RS25230	COG4459	periplasmic nitrate reductase
AA2016_RS25235	COG1959	2 iron, 2 sulfur cluster binding
AA2016_RS25260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA2016_RS25275	COG0714	Associated with various cellular activities
AA2016_RS25280	COG3256	nitric oxide reductase
AA2016_RS25295	COG1845	cytochrome c oxidase, subunit III
AA2016_RS25315	COG4521	taurine ABC transporter
AA2016_RS25350	COG5489	Protein of unknown function (DUF736)
AA2016_RS25360	COG3916	Acyl-homoserine-lactone synthase
AA2016_RS25365	COG2197	response regulator
AA2016_RS25375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AA2016_RS25395	COG4957	zinc ion binding
AA2016_RS25430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_RS25435	COG0765	amino acid transport
AA2016_RS25440	COG0765	amino acid transport
AA2016_RS25445	COG1126	abc transporter atp-binding protein
AA2016_RS25450	COG3608	succinylglutamate desuccinylase aspartoacylase
AA2016_RS25490	COG0741	lytic transglycosylase activity
AA2016_RS25495	COG2433	Pfam Transposase IS66
AA2016_RS25500	COG3436	PFAM IS66 Orf2 family protein
AA2016_RS25525	COG1522	sequence-specific DNA binding
AA2016_RS25535	COG4962	Type ii secretion system protein e
AA2016_RS25540	COG3838	Conjugal transfer protein Trbc
AA2016_RS25550	COG3451	type IV secretory pathway VirB4
AA2016_RS25565	COG3846	protein secretion by the type IV secretion system
AA2016_RS25580	COG2948	multi-organism process
AA2016_RS25595	COG3550	peptidyl-serine autophosphorylation
AA2016_RS25600	COG1396	sequence-specific DNA binding
AA2016_RS25635	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AA2016_RS25640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA2016_RS25640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA2016_RS25645	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AA2016_RS25655	COG0583	DNA-binding transcription factor activity
AA2016_RS25660	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AA2016_RS25665	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AA2016_RS25670	COG0124	histidyl-tRNA synthetase
AA2016_RS25685	COG2818	Glycosylase
AA2016_RS25690	COG1376	ErfK ybiS ycfS ynhG family protein
AA2016_RS25695	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AA2016_RS25700	COG1388	LysM domain
AA2016_RS25700	COG1376	ErfK ybiS ycfS ynhG family protein
AA2016_RS25710	COG0247	lactate metabolic process
AA2016_RS25725	COG2852	Protein conserved in bacteria
AA2016_RS25735	COG0277	FAD linked oxidase domain protein
AA2016_RS25745	COG2186	Transcriptional regulator
AA2016_RS25750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AA2016_RS25810	COG0583	DNA-binding transcription factor activity
AA2016_RS25815	COG1570	exodeoxyribonuclease VII activity
AA2016_RS25825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA2016_RS25830	COG1178	ABC-type Fe3 transport system permease component
AA2016_RS25835	COG1840	ABC-type Fe3 transport system, periplasmic component
AA2016_RS25840	COG2205	protein histidine kinase activity
AA2016_RS25845	COG5490	Phasin protein
AA2016_RS25870	COG1177	transmembrane transport
AA2016_RS25875	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2016_RS25880	COG3842	ATPase activity
AA2016_RS25900	COG2814	Major facilitator Superfamily
AA2016_RS25910	COG3300	MHYT domain
AA2016_RS25910	COG5001	Diguanylate cyclase
AA2016_RS25920	COG2224	Isocitrate lyase
AA2016_RS25940	COG0174	glutamine synthetase
AA2016_RS25945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_RS25955	COG0745	RESPONSE REGULATOR receiver
AA2016_RS25975	COG1595	DNA-templated transcription, initiation
AA2016_RS25995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AA2016_RS26000	COG0363	glucosamine-6-phosphate deaminase activity
AA2016_RS26005	COG0129	dihydroxy-acid dehydratase activity
AA2016_RS26015	COG0488	(ABC) transporter
AA2016_RS26030	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AA2016_RS26050	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AA2016_RS26085	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AA2016_RS26090	COG4149	molybdate abc transporter
AA2016_RS26095	COG0725	ABC transporter, periplasmic molybdate-binding protein
AA2016_RS26100	COG0730	response to heat
AA2016_RS26105	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AA2016_RS26110	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AA2016_RS26120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA2016_RS26145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AA2016_RS26155	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AA2016_RS26160	COG5328	Belongs to the UPF0262 family
AA2016_RS26170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AA2016_RS26175	COG0424	maF-like protein
AA2016_RS26180	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AA2016_RS26195	COG1136	(ABC) transporter
AA2016_RS26195	COG0577	efflux transmembrane transporter activity
AA2016_RS26200	COG1136	(ABC) transporter
AA2016_RS26220	COG5001	Diguanylate cyclase
AA2016_RS26220	COG3300	MHYT domain
AA2016_RS26230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_RS26235	COG2186	Transcriptional regulator
AA2016_RS26265	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AA2016_RS26270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2016_RS26300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA2016_RS26310	COG0251	oxidation-reduction process
AA2016_RS26320	COG0765	amino acid transport
AA2016_RS26325	COG0765	amino acid transport
AA2016_RS26345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AA2016_RS26350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA2016_RS26355	COG1120	ATPase activity
AA2016_RS26360	COG3585	molybdate ion transport
AA2016_RS26375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_RS26380	COG4215	(ABC) transporter
AA2016_RS26385	COG0765	amino acid transport
AA2016_RS26390	COG3457	Alanine racemase
AA2016_RS26395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2016_RS26405	COG0156	8-amino-7-oxononanoate synthase activity
AA2016_RS26410	COG0436	Aminotransferase
AA2016_RS26415	COG1970	mechanosensitive ion channel activity
AA2016_RS26420	COG2198	Histidine kinase
AA2016_RS26420	COG0784	Response regulator, receiver
AA2016_RS26420	COG2205	protein histidine kinase activity
AA2016_RS26440	COG0167	dihydroorotate dehydrogenase activity
AA2016_RS26450	COG0123	including yeast histone deacetylase and acetoin utilization protein
AA2016_RS26460	COG5001	Diguanylate cyclase
AA2016_RS26470	COG0463	Glycosyl transferase, family 2
AA2016_RS26485	COG0717	Belongs to the dCTP deaminase family
AA2016_RS26495	COG2967	ApaG domain
AA2016_RS26505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AA2016_RS26510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AA2016_RS26520	COG0598	Magnesium transport protein CorA
AA2016_RS26525	COG0704	Plays a role in the regulation of phosphate uptake
AA2016_RS26535	COG0640	Transcriptional regulator
AA2016_RS26540	COG5002	protein histidine kinase activity
AA2016_RS26545	COG2326	polyphosphate kinase activity
AA2016_RS26550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_RS26560	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AA2016_RS26590	COG1024	Enoyl-CoA hydratase
AA2016_RS26590	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA2016_RS26595	COG0183	Belongs to the thiolase family
AA2016_RS26600	COG1960	acyl-CoA dehydrogenase activity
AA2016_RS26605	COG1960	acyl-CoA dehydrogenase activity
AA2016_RS26615	COG0730	response to heat
AA2016_RS26625	COG0789	Transcriptional regulator
AA2016_RS26635	COG1201	RNA secondary structure unwinding
AA2016_RS26650	COG1793	dna ligase
AA2016_RS26705	COG3422	double-strand break repair
AA2016_RS26720	COG0444	Belongs to the ABC transporter superfamily
AA2016_RS26725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS26735	COG0747	negative chemotaxis
AA2016_RS26740	COG4608	Belongs to the ABC transporter superfamily
AA2016_RS26745	COG0444	Belongs to the ABC transporter superfamily
AA2016_RS26750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2016_RS26755	COG0601	transmembrane transport
AA2016_RS26760	COG0747	negative chemotaxis
AA2016_RS26765	COG0318	PFAM AMP-dependent synthetase and ligase
AA2016_RS26775	COG0024	Methionine aminopeptidase
AA2016_RS26795	COG2226	methyltransferase
AA2016_RS26800	COG0129	dihydroxy-acid dehydratase activity
AA2016_RS26870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA2016_RS26875	COG0166	Belongs to the GPI family
AA2016_RS26890	COG0489	protein tyrosine kinase activity
AA2016_RS26915	COG0583	DNA-binding transcription factor activity
AA2016_RS26930	COG3383	formate dehydrogenase (NAD+) activity
AA2016_RS26935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AA2016_RS26945	COG2197	response regulator
AA2016_RS26980	COG5002	protein histidine kinase activity
AA2016_RS26985	COG1349	DNA-binding transcription factor activity
AA2016_RS26995	COG0517	IMP dehydrogenase activity
AA2016_RS26995	COG4175	Glycine betaine
AA2016_RS27000	COG4176	ABC-type proline glycine betaine transport system permease component
AA2016_RS27015	COG2340	Cysteine-rich secretory protein family
AA2016_RS27020	COG0697	spore germination
AA2016_RS27030	COG0402	S-adenosylhomocysteine deaminase activity
AA2016_RS27035	COG1079	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS27040	COG4603	Belongs to the binding-protein-dependent transport system permease family
AA2016_RS27045	COG3845	ABC transporter
AA2016_RS27055	COG1132	(ABC) transporter
AA2016_RS27060	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_RS27065	COG0288	reversible hydration of carbon dioxide
AA2016_RS27095	COG5002	protein histidine kinase activity
AA2016_RS27100	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AA2016_RS27105	COG0594	ribonuclease P activity
AA2016_RS27110	COG0706	membrane insertase activity
AA2016_RS27120	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AA2016_RS27130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA2016_RS27135	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AA2016_RS27150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AA2016_RS27165	COG3186	Phenylalanine-4-hydroxylase
AA2016_RS27175	COG0477	Major facilitator Superfamily
AA2016_RS27180	COG3706	GGDEF domain
AA2016_RS27190	COG3739	integral membrane protein
AA2016_RS27200	COG2171	N-acyltransferase activity
AA2016_RS27210	COG3152	Membrane
AA2016_RS27230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA2016_RS27250	COG0101	tRNA pseudouridine synthase activity
AA2016_RS27260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AA2016_RS27265	COG0242	peptide deformylase activity
AA2016_RS27300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA2016_RS27310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AA2016_RS27315	COG3409	Peptidoglycan-binding domain 1 protein
AA2016_RS27315	COG3773	Cell wall hydrolase
AA2016_RS27325	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AA2016_RS27330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AA2016_RS27350	COG2816	NAD+ diphosphatase activity
AA2016_RS27355	COG2226	methyltransferase
AA2016_RS27360	COG0077	Prephenate dehydratase
AA2016_RS27360	COG1605	Chorismate mutase
AA2016_RS27365	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AA2016_RS27370	COG3474	cytochrome
AA2016_RS27375	COG4166	transmembrane transport
AA2016_RS27380	COG4166	transmembrane transport
AA2016_RS27385	COG4174	ABC transporter (Permease)
AA2016_RS27390	COG4239	(ABC) transporter, permease
AA2016_RS27395	COG4172	Belongs to the ABC transporter superfamily
AA2016_RS27405	COG0791	NLP P60 protein
AA2016_RS27415	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AA2016_RS27450	COG4964	Belongs to the GSP D family
AA2016_RS27480	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AA2016_RS27485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AA2016_RS27490	COG1024	Enoyl-CoA hydratase
AA2016_RS27495	COG0268	Binds directly to 16S ribosomal RNA
AA2016_RS27550	COG5001	Diguanylate cyclase
AA2016_RS27550	COG3300	MHYT domain
AA2016_RS28020	COG2205	protein histidine kinase activity
AA2016_RS28035	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AA2016_RS28040	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AA2016_RS28410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AA2016_RS28410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AA2016_RS28420	COG2274	protein secretion by the type I secretion system
AA2016_RS28860	COG3842	ATPase activity
AA2016_RS29025	COG0154	amidase activity
AA2016_RS29255	COG3706	GGDEF domain
AA2016_RS29575	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AA2016_RS29670	COG1012	belongs to the aldehyde dehydrogenase family
AA2016_RS30100	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AA2016_RS30290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA2016_RS30400	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AA2016_RS30700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AA2016_RS30700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AA2016_RS30835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2016_RS30995	COG0175	sulfate reduction
AA2016_RS31020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA2016_RS31020	COG4651	solute:proton antiporter activity
AA2016_RS31075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA2016_RS31115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA2016_RS31115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA2016_RS31120	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA2016_RS31120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA2016_RS31175	COG3842	ATPase activity
AA2016_RS31610	COG2755	lipolytic protein G-D-S-L family
AA2016_RS31610	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AA2016_RS31975	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AA2016_RS32385	COG2205	protein histidine kinase activity
AA2016_RS32480	COG3845	ABC transporter
AA2016_RS32570	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA2016_RS32605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AA2016_RS32615	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AA2016_RS32630	COG5001	Diguanylate cyclase
AA2016_RS32675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AA2016_RS32720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AA2016_RS32735	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AA2016_RS32965	COG1420	regulation of RNA biosynthetic process
AA2016_RS33160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine