locus-tag	class	description
H5P29_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H5P29_RS00040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5P29_RS00050	COG0735	belongs to the Fur family
H5P29_RS00055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5P29_RS00065	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H5P29_RS00070	COG3300	MHYT domain
H5P29_RS00070	COG5001	Diguanylate cyclase
H5P29_RS00075	COG2813	Specifically methylates the guanine in position
H5P29_RS00085	COG1185	polyribonucleotide nucleotidyltransferase activity
H5P29_RS00090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H5P29_RS00095	COG0598	Magnesium transport protein CorA
H5P29_RS00100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H5P29_RS00105	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H5P29_RS00110	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H5P29_RS00125	COG0779	Required for maturation of 30S ribosomal subunits
H5P29_RS00165	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H5P29_RS00170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H5P29_RS00175	COG1396	sequence-specific DNA binding
H5P29_RS00180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H5P29_RS00185	COG1253	flavin adenine dinucleotide binding
H5P29_RS00190	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H5P29_RS00195	COG1702	phosphate starvation-inducible protein PhoH
H5P29_RS00200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5P29_RS00220	COG1214	PFAM Peptidase M22, glycoprotease
H5P29_RS00225	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H5P29_RS00255	COG0481	GTPase activity
H5P29_RS00275	COG3220	belongs to the UPF0276 family
H5P29_RS00315	COG0671	phosphoesterase, PA-phosphatase related
H5P29_RS00325	COG0659	secondary active sulfate transmembrane transporter activity
H5P29_RS00330	COG0443	Heat shock 70 kDa protein
H5P29_RS00345	COG2358	TRAP transporter, solute receptor (TAXI family
H5P29_RS00365	COG3795	YCII-related domain
H5P29_RS00380	COG0640	Transcriptional regulator
H5P29_RS00415	COG0842	Transport permease protein
H5P29_RS00420	COG1131	(ABC) transporter
H5P29_RS00435	COG2954	triphosphatase activity
H5P29_RS00455	COG1420	regulation of RNA biosynthetic process
H5P29_RS00460	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H5P29_RS00470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H5P29_RS00475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5P29_RS00495	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H5P29_RS00500	COG0792	nuclease activity
H5P29_RS00510	COG1254	Belongs to the acylphosphatase family
H5P29_RS00515	COG2124	cytochrome p450
H5P29_RS00545	COG0745	RESPONSE REGULATOR receiver
H5P29_RS00550	COG2205	protein histidine kinase activity
H5P29_RS00555	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H5P29_RS00560	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H5P29_RS00565	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H5P29_RS00590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H5P29_RS00595	COG2226	methyltransferase
H5P29_RS00600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H5P29_RS00605	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H5P29_RS00625	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H5P29_RS00640	COG1079	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS00650	COG3845	ABC transporter
H5P29_RS00655	COG2900	Belongs to the SlyX family
H5P29_RS00665	COG1744	ABC transporter substrate-binding protein PnrA-like
H5P29_RS00670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5P29_RS00755	COG3750	Belongs to the UPF0335 family
H5P29_RS00775	COG5484	DNA packaging
H5P29_RS00775	COG3728	DNA packaging
H5P29_RS00965	COG1396	sequence-specific DNA binding
H5P29_RS01045	COG1477	protein flavinylation
H5P29_RS01060	COG1136	(ABC) transporter
H5P29_RS01060	COG0577	efflux transmembrane transporter activity
H5P29_RS01085	COG1278	Cold shock
H5P29_RS01115	COG1176	ABC-type spermidine putrescine transport system, permease component I
H5P29_RS01145	COG0251	oxidation-reduction process
H5P29_RS01160	COG0662	Cupin 2, conserved barrel domain protein
H5P29_RS01170	COG0848	biopolymer transport protein
H5P29_RS01220	COG1082	Xylose isomerase domain protein TIM barrel
H5P29_RS01225	COG4607	ABC-type enterochelin transport system periplasmic component
H5P29_RS01230	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5P29_RS01235	COG4605	iron ion homeostasis
H5P29_RS01240	COG4604	ABC transporter, ATP-binding protein
H5P29_RS01245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5P29_RS01250	COG4638	Rieske (2fe-2S)
H5P29_RS01285	COG4771	TonB-dependent receptor
H5P29_RS01290	COG4178	(ABC) transporter
H5P29_RS01310	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H5P29_RS01315	COG0459	protein refolding
H5P29_RS01355	COG0395	ABC-type sugar transport system, permease component
H5P29_RS01360	COG1175	transmembrane transport
H5P29_RS01375	COG1765	OsmC-like protein
H5P29_RS01380	COG2766	serine protein kinase
H5P29_RS01385	COG2718	Belongs to the UPF0229 family
H5P29_RS01390	COG2719	SpoVR family
H5P29_RS01395	COG3142	Participates in the control of copper homeostasis
H5P29_RS01400	COG1940	carbohydrate kinase activity
H5P29_RS01410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5P29_RS01415	COG1446	asparaginase
H5P29_RS01425	COG0765	amino acid transport
H5P29_RS01430	COG0765	amino acid transport
H5P29_RS01465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5P29_RS01500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5P29_RS01505	COG1280	lysine exporter protein (LysE YggA)
H5P29_RS01510	COG1957	nucleoside hydrolase
H5P29_RS01525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5P29_RS01530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H5P29_RS01535	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H5P29_RS01540	COG1137	ATPase activity
H5P29_RS01545	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H5P29_RS01555	COG0616	signal peptide processing
H5P29_RS01560	COG0776	regulation of translation
H5P29_RS01570	COG2423	ornithine cyclodeaminase activity
H5P29_RS01585	COG2378	regulation of single-species biofilm formation
H5P29_RS01590	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H5P29_RS01590	COG0116	Belongs to the methyltransferase superfamily
H5P29_RS01595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5P29_RS01600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H5P29_RS01610	COG2205	protein histidine kinase activity
H5P29_RS01610	COG0784	Response regulator, receiver
H5P29_RS01610	COG5002	protein histidine kinase activity
H5P29_RS01635	COG1252	NADH dehydrogenase
H5P29_RS01640	COG2860	membrane
H5P29_RS01645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H5P29_RS01660	COG0175	sulfate reduction
H5P29_RS01665	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5P29_RS01675	COG1648	precorrin-2 dehydrogenase activity
H5P29_RS01675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5P29_RS01685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5P29_RS01685	COG4651	solute:proton antiporter activity
H5P29_RS01705	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H5P29_RS01730	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5P29_RS01735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5P29_RS01740	COG1942	4-Oxalocrotonate Tautomerase
H5P29_RS01755	COG1733	regulation of RNA biosynthetic process
H5P29_RS01765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5P29_RS01765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5P29_RS01780	COG0667	Aldo Keto reductase
H5P29_RS01785	COG0673	inositol 2-dehydrogenase activity
H5P29_RS01800	COG0395	ABC-type sugar transport system, permease component
H5P29_RS01805	COG1175	transmembrane transport
H5P29_RS01820	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H5P29_RS01830	COG0803	Belongs to the bacterial solute-binding protein 9 family
H5P29_RS01835	COG1121	(ABC) transporter
H5P29_RS01840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5P29_RS01845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5P29_RS01850	COG3842	ATPase activity
H5P29_RS01855	COG0366	Alpha amylase catalytic
H5P29_RS01860	COG0395	ABC-type sugar transport system, permease component
H5P29_RS01865	COG1175	transmembrane transport
H5P29_RS01870	COG1653	transport
H5P29_RS01875	COG1609	Transcriptional regulator
H5P29_RS01880	COG1802	Transcriptional regulator
H5P29_RS01885	COG2272	Belongs to the type-B carboxylesterase lipase family
H5P29_RS01890	COG0543	2 iron, 2 sulfur cluster binding
H5P29_RS01890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5P29_RS01905	COG1595	DNA-templated transcription, initiation
H5P29_RS01915	COG1404	Belongs to the peptidase S8 family
H5P29_RS01925	COG3811	Belongs to the UPF0386 family
H5P29_RS01945	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS01980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5P29_RS01990	COG0154	amidase activity
H5P29_RS01995	COG0747	negative chemotaxis
H5P29_RS02000	COG0601	transmembrane transport
H5P29_RS02005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS02030	COG0625	glutathione transferase activity
H5P29_RS02105	COG4974	Belongs to the 'phage' integrase family
H5P29_RS02110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5P29_RS02115	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS02120	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H5P29_RS02125	COG1024	Enoyl-CoA hydratase
H5P29_RS02130	COG0683	leucine binding
H5P29_RS02155	COG4948	Mandelate Racemase Muconate Lactonizing
H5P29_RS02185	COG0444	Belongs to the ABC transporter superfamily
H5P29_RS02190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS02195	COG0601	transmembrane transport
H5P29_RS02215	COG2197	response regulator
H5P29_RS02225	COG0583	DNA-binding transcription factor activity
H5P29_RS02265	COG3451	type IV secretory pathway VirB4
H5P29_RS02275	COG3838	Conjugal transfer protein Trbc
H5P29_RS02280	COG4962	Type ii secretion system protein e
H5P29_RS02355	COG4957	zinc ion binding
H5P29_RS02375	COG0556	nucleotide-excision repair
H5P29_RS02395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5P29_RS02410	COG1116	anion transmembrane transporter activity
H5P29_RS02410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5P29_RS02415	COG1116	anion transmembrane transporter activity
H5P29_RS02425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5P29_RS02435	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H5P29_RS02445	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H5P29_RS02470	COG2084	Dehydrogenase
H5P29_RS02475	COG3265	gluconokinase activity
H5P29_RS02480	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS02485	COG1063	alcohol dehydrogenase
H5P29_RS02490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5P29_RS02505	COG0765	amino acid transport
H5P29_RS02510	COG0765	amino acid transport
H5P29_RS02520	COG0583	DNA-binding transcription factor activity
H5P29_RS02550	COG1072	(Pantothenic acid kinase))
H5P29_RS02555	COG0625	glutathione transferase activity
H5P29_RS02570	COG0829	nickel cation binding
H5P29_RS02580	COG3813	Protein conserved in bacteria
H5P29_RS02590	COG0832	Belongs to the urease beta subunit family
H5P29_RS02615	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H5P29_RS02620	COG0830	nickel cation binding
H5P29_RS02630	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H5P29_RS02640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5P29_RS02655	COG0534	Mate efflux family protein
H5P29_RS02670	COG1176	ABC-type spermidine putrescine transport system, permease component I
H5P29_RS02675	COG3842	ATPase activity
H5P29_RS02685	COG0765	amino acid transport
H5P29_RS02690	COG0765	amino acid transport
H5P29_RS02705	COG0583	DNA-binding transcription factor activity
H5P29_RS02710	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H5P29_RS02735	COG1129	ABC transporter
H5P29_RS02750	COG1335	isochorismatase
H5P29_RS02780	COG1846	Transcriptional regulator
H5P29_RS02785	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS02790	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H5P29_RS02815	COG0673	inositol 2-dehydrogenase activity
H5P29_RS02820	COG0395	ABC-type sugar transport system, permease component
H5P29_RS02835	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H5P29_RS02840	COG2971	BadF BadG BcrA BcrD
H5P29_RS02845	COG2188	Transcriptional regulator
H5P29_RS02850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H5P29_RS02855	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H5P29_RS02880	COG1879	ABC-type sugar transport system periplasmic component
H5P29_RS02890	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS02900	COG1609	Transcriptional regulator
H5P29_RS02910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5P29_RS02920	COG4941	Belongs to the sigma-70 factor family
H5P29_RS02925	COG3795	YCII-related domain
H5P29_RS02930	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5P29_RS02985	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H5P29_RS02990	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H5P29_RS02995	COG4335	DNA alkylation repair
H5P29_RS03015	COG0121	glutamine amidotransferase
H5P29_RS03025	COG1522	sequence-specific DNA binding
H5P29_RS03030	COG0756	dUTP diphosphatase activity
H5P29_RS03035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5P29_RS03040	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H5P29_RS03050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5P29_RS03060	COG0281	malic enzyme
H5P29_RS03060	COG0280	phosphate acetyltransferase
H5P29_RS03065	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H5P29_RS03095	COG0596	Alpha beta hydrolase
H5P29_RS03105	COG2207	Transcriptional regulator
H5P29_RS03105	COG0662	Cupin 2, conserved barrel domain protein
H5P29_RS03140	COG5001	Diguanylate cyclase
H5P29_RS03140	COG5002	protein histidine kinase activity
H5P29_RS03150	COG0656	L-ascorbic acid biosynthetic process
H5P29_RS03170	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H5P29_RS03175	COG0728	peptidoglycan biosynthetic process
H5P29_RS03190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H5P29_RS03190	COG0463	Glycosyl transferase, family 2
H5P29_RS03195	COG0180	Tryptophanyl-tRNA synthetase
H5P29_RS03205	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H5P29_RS03210	COG1376	ErfK ybiS ycfS ynhG family protein
H5P29_RS03220	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H5P29_RS03230	COG1643	Atp-dependent helicase
H5P29_RS03240	COG0673	inositol 2-dehydrogenase activity
H5P29_RS03245	COG1737	Transcriptional regulator
H5P29_RS03250	COG0129	dihydroxy-acid dehydratase activity
H5P29_RS03265	COG0626	cystathionine gamma-synthase activity
H5P29_RS03270	COG1846	Transcriptional regulator
H5P29_RS03275	COG0697	spore germination
H5P29_RS03295	COG1116	anion transmembrane transporter activity
H5P29_RS03315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5P29_RS03335	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS03345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H5P29_RS03350	COG1802	Transcriptional regulator
H5P29_RS03355	COG0579	oxidoreductase
H5P29_RS03365	COG1522	sequence-specific DNA binding
H5P29_RS03370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5P29_RS03375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5P29_RS03380	COG2186	Transcriptional regulator
H5P29_RS03385	COG0626	cystathionine gamma-synthase activity
H5P29_RS03400	COG0395	ABC-type sugar transport system, permease component
H5P29_RS03405	COG3842	ATPase activity
H5P29_RS03410	COG0840	transmembrane signaling receptor activity
H5P29_RS03420	COG0745	RESPONSE REGULATOR receiver
H5P29_RS03425	COG0643	Histidine kinase
H5P29_RS03425	COG2198	Histidine kinase
H5P29_RS03430	COG0835	chemotaxis
H5P29_RS03435	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H5P29_RS03440	COG2201	protein-glutamate methylesterase activity
H5P29_RS03445	COG0745	RESPONSE REGULATOR receiver
H5P29_RS03450	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H5P29_RS03475	COG0464	growth
H5P29_RS03515	COG4957	zinc ion binding
H5P29_RS03555	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H5P29_RS03555	COG2755	lipolytic protein G-D-S-L family
H5P29_RS03580	COG1376	ErfK ybiS ycfS ynhG family protein
H5P29_RS03610	COG4964	Belongs to the GSP D family
H5P29_RS03715	COG0156	8-amino-7-oxononanoate synthase activity
H5P29_RS03720	COG1063	alcohol dehydrogenase
H5P29_RS03730	COG4608	Belongs to the ABC transporter superfamily
H5P29_RS03740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS03745	COG0601	transmembrane transport
H5P29_RS03760	COG2186	Transcriptional regulator
H5P29_RS03775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H5P29_RS03780	COG0346	lactoylglutathione lyase activity
H5P29_RS03785	COG0346	lactoylglutathione lyase activity
H5P29_RS03795	COG2124	cytochrome p450
H5P29_RS03820	COG1846	Transcriptional regulator
H5P29_RS03825	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H5P29_RS03840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5P29_RS03875	COG0436	Aminotransferase
H5P29_RS03885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5P29_RS03895	COG1473	amidohydrolase
H5P29_RS03900	COG1957	nucleoside hydrolase
H5P29_RS03905	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H5P29_RS03915	COG0402	S-adenosylhomocysteine deaminase activity
H5P29_RS03920	COG3842	ATPase activity
H5P29_RS03925	COG1177	transmembrane transport
H5P29_RS03930	COG1176	ABC-type spermidine putrescine transport system, permease component I
H5P29_RS03950	COG0156	8-amino-7-oxononanoate synthase activity
H5P29_RS03960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS03965	COG0601	transmembrane transport
H5P29_RS03985	COG4172	Belongs to the ABC transporter superfamily
H5P29_RS04005	COG0747	negative chemotaxis
H5P29_RS04035	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H5P29_RS04040	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS04045	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H5P29_RS04050	COG0539	negative regulation of cytoplasmic translation
H5P29_RS04070	COG1309	transcriptional regulator
H5P29_RS04080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5P29_RS04085	COG4215	(ABC) transporter
H5P29_RS04095	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H5P29_RS04125	COG1968	undecaprenyl-diphosphatase activity
H5P29_RS04135	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H5P29_RS04145	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
H5P29_RS04150	COG1803	Methylglyoxal synthase
H5P29_RS04155	COG0837	glucose binding
H5P29_RS04160	COG1132	(ABC) transporter
H5P29_RS04165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H5P29_RS04170	COG0588	phosphoglycerate mutase activity
H5P29_RS04220	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H5P29_RS04230	COG3386	PFAM SMP-30 Gluconolaconase
H5P29_RS04235	COG0800	Aldolase
H5P29_RS04240	COG3734	2-keto-3-deoxy-galactonokinase
H5P29_RS04245	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS04250	COG5001	Diguanylate cyclase
H5P29_RS04260	COG1309	transcriptional regulator
H5P29_RS04265	COG0189	ligase activity
H5P29_RS04280	COG5001	Diguanylate cyclase
H5P29_RS04305	COG0284	orotidine-5'-phosphate decarboxylase activity
H5P29_RS04315	COG3963	phosphatidate phosphatase activity
H5P29_RS04320	COG0484	heat shock protein binding
H5P29_RS04330	COG0443	Heat shock 70 kDa protein
H5P29_RS04355	COG3038	cytochrome b561
H5P29_RS04365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5P29_RS04365	COG0072	phenylalanine-tRNA ligase activity
H5P29_RS04375	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H5P29_RS04380	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H5P29_RS04385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H5P29_RS04395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H5P29_RS04405	COG3135	benzoate transporter
H5P29_RS04420	COG0583	DNA-binding transcription factor activity
H5P29_RS04425	COG0135	phosphoribosylanthranilate isomerase activity
H5P29_RS04430	COG0133	tryptophan synthase activity
H5P29_RS04435	COG0159	tryptophan synthase activity
H5P29_RS04440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H5P29_RS04455	COG1074	ATP-dependent DNA helicase activity
H5P29_RS04460	COG2887	Belongs to the helicase family. UvrD subfamily
H5P29_RS04465	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H5P29_RS04470	COG3178	'Phosphotransferase
H5P29_RS04475	COG2205	protein histidine kinase activity
H5P29_RS04480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H5P29_RS04485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5P29_RS04490	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5P29_RS04490	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5P29_RS04500	COG2205	protein histidine kinase activity
H5P29_RS04505	COG0745	RESPONSE REGULATOR receiver
H5P29_RS04510	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H5P29_RS04520	COG1652	LysM domain
H5P29_RS04530	COG1072	(Pantothenic acid kinase))
H5P29_RS04535	COG0140	phosphoribosyl-ATP diphosphatase activity
H5P29_RS04545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H5P29_RS04555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H5P29_RS04565	COG0131	Imidazoleglycerol-phosphate dehydratase
H5P29_RS04570	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H5P29_RS04590	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H5P29_RS04600	COG1396	sequence-specific DNA binding
H5P29_RS04600	COG3800	Transcriptional regulator
H5P29_RS04620	COG3030	protein affecting phage T7 exclusion by the F plasmid
H5P29_RS04625	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H5P29_RS04635	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5P29_RS04640	COG0237	dephospho-CoA kinase activity
H5P29_RS04645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H5P29_RS04650	COG0424	maF-like protein
H5P29_RS04655	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H5P29_RS04660	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H5P29_RS04665	COG1981	membrane
H5P29_RS04670	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H5P29_RS04675	COG1331	Highly conserved protein containing a thioredoxin domain
H5P29_RS04680	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H5P29_RS04685	COG0445	tRNA wobble uridine modification
H5P29_RS04690	COG0357	Ribosomal RNA small subunit methyltransferase G
H5P29_RS04760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5P29_RS04770	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H5P29_RS04770	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H5P29_RS04780	COG4770	biotin carboxylase activity
H5P29_RS04785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H5P29_RS04795	COG1396	sequence-specific DNA binding
H5P29_RS04795	COG3800	Transcriptional regulator
H5P29_RS04805	COG2183	response to ionizing radiation
H5P29_RS04810	COG0137	argininosuccinate synthase activity
H5P29_RS04840	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H5P29_RS04845	COG1605	Chorismate mutase
H5P29_RS04845	COG0287	Prephenate dehydrogenase
H5P29_RS04850	COG0228	four-way junction DNA binding
H5P29_RS04855	COG5001	Diguanylate cyclase
H5P29_RS04865	COG3781	membrane
H5P29_RS04875	COG0454	-acetyltransferase
H5P29_RS04880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H5P29_RS04895	COG4178	(ABC) transporter
H5P29_RS04900	COG3152	Membrane
H5P29_RS04905	COG0473	3-isopropylmalate dehydrogenase activity
H5P29_RS04915	COG0251	oxidation-reduction process
H5P29_RS04925	COG0066	3-isopropylmalate dehydratase activity
H5P29_RS04935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5P29_RS04940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5P29_RS04945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5P29_RS04950	COG1120	ATPase activity
H5P29_RS04955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5P29_RS04965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5P29_RS04970	COG0525	valine-tRNA ligase activity
H5P29_RS04975	COG0765	amino acid transport
H5P29_RS04980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5P29_RS04995	COG2814	Major facilitator Superfamily
H5P29_RS05025	COG1595	DNA-templated transcription, initiation
H5P29_RS05060	COG2195	Cleaves the N-terminal amino acid of tripeptides
H5P29_RS05075	COG2301	Belongs to the HpcH HpaI aldolase family
H5P29_RS05100	COG0587	DNA-directed DNA polymerase activity
H5P29_RS05105	COG2835	tetraacyldisaccharide 4'-kinase activity
H5P29_RS05110	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H5P29_RS05115	COG3118	belongs to the thioredoxin family
H5P29_RS05135	COG0010	Belongs to the arginase family
H5P29_RS05140	COG0436	Aminotransferase
H5P29_RS05160	COG0463	Glycosyl transferase, family 2
H5P29_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS05175	COG4948	Mandelate Racemase Muconate Lactonizing
H5P29_RS05180	COG0179	Fumarylacetoacetate (FAA) hydrolase
H5P29_RS05190	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS05205	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS05215	COG4154	Belongs to the RbsD FucU family
H5P29_RS05220	COG4608	Belongs to the ABC transporter superfamily
H5P29_RS05225	COG0444	Belongs to the ABC transporter superfamily
H5P29_RS05230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS05235	COG0601	transmembrane transport
H5P29_RS05240	COG0747	negative chemotaxis
H5P29_RS05250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H5P29_RS05265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H5P29_RS05285	COG3339	Conserved Protein
H5P29_RS05290	COG2154	pterin-4-alpha-carbinolamine dehydratase
H5P29_RS05295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H5P29_RS05310	COG1136	(ABC) transporter
H5P29_RS05315	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H5P29_RS05320	COG0670	Belongs to the BI1 family
H5P29_RS05330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H5P29_RS05335	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS05355	COG1276	copper resistance
H5P29_RS05355	COG2372	response to copper ion
H5P29_RS05370	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS05375	COG3300	MHYT domain
H5P29_RS05375	COG5001	Diguanylate cyclase
H5P29_RS05410	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H5P29_RS05420	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H5P29_RS05425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5P29_RS05430	COG0552	protein localization to endoplasmic reticulum
H5P29_RS05435	COG2917	probably involved in intracellular septation
H5P29_RS05445	COG0431	NADPH-dependent FMN reductase
H5P29_RS05460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5P29_RS05470	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5P29_RS05475	COG4133	protoheme IX ABC transporter activity
H5P29_RS05480	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H5P29_RS05490	COG0039	L-malate dehydrogenase activity
H5P29_RS05495	COG0045	succinate-CoA ligase (ADP-forming) activity
H5P29_RS05500	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H5P29_RS05505	COG0567	Dehydrogenase, E1 component
H5P29_RS05510	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5P29_RS05525	COG1280	lysine exporter protein (LysE YggA)
H5P29_RS05535	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS05560	COG4974	Belongs to the 'phage' integrase family
H5P29_RS05565	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H5P29_RS05580	COG0335	large ribosomal subunit rRNA binding
H5P29_RS05585	COG0456	acetyltransferase
H5P29_RS05605	COG0765	amino acid transport
H5P29_RS05640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H5P29_RS05655	COG2009	succinate dehydrogenase
H5P29_RS05685	COG3132	Protein of unknown function, DUF480
H5P29_RS05690	COG3541	Predicted nucleotidyltransferase
H5P29_RS05710	COG1764	response to oxidative stress
H5P29_RS05715	COG3795	YCII-related domain
H5P29_RS05720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5P29_RS05725	COG1946	Acyl-CoA thioesterase
H5P29_RS05730	COG0347	Belongs to the P(II) protein family
H5P29_RS05735	COG0004	ammonium transporteR
H5P29_RS05755	COG2261	transglycosylase associated protein
H5P29_RS05755	COG1674	ftsk spoiiie
H5P29_RS05760	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H5P29_RS05775	COG0745	RESPONSE REGULATOR receiver
H5P29_RS05790	COG0583	DNA-binding transcription factor activity
H5P29_RS05795	COG2264	protein methyltransferase activity
H5P29_RS05810	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H5P29_RS05815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H5P29_RS05820	COG0181	hydroxymethylbilane synthase activity
H5P29_RS05845	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H5P29_RS05870	COG3307	-O-antigen
H5P29_RS05875	COG1596	polysaccharide export
H5P29_RS05895	COG1215	transferase activity, transferring glycosyl groups
H5P29_RS05905	COG2273	Hydrolase Family 16
H5P29_RS05935	COG0438	transferase activity, transferring glycosyl groups
H5P29_RS05940	COG1215	transferase activity, transferring glycosyl groups
H5P29_RS05945	COG1215	transferase activity, transferring glycosyl groups
H5P29_RS05950	COG1215	transferase activity, transferring glycosyl groups
H5P29_RS05955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H5P29_RS05960	COG0489	protein tyrosine kinase activity
H5P29_RS05960	COG3206	protein involved in exopolysaccharide biosynthesis
H5P29_RS05965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H5P29_RS05975	COG3920	Histidine kinase
H5P29_RS05980	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H5P29_RS05980	COG2755	lipolytic protein G-D-S-L family
H5P29_RS05990	COG3239	Fatty acid desaturase
H5P29_RS06005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5P29_RS06010	COG0747	negative chemotaxis
H5P29_RS06015	COG0601	transmembrane transport
H5P29_RS06020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS06025	COG4172	Belongs to the ABC transporter superfamily
H5P29_RS06040	COG3284	Transcriptional regulator
H5P29_RS06060	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS06070	COG3119	arylsulfatase activity
H5P29_RS06090	COG1940	carbohydrate kinase activity
H5P29_RS06095	COG0730	response to heat
H5P29_RS06100	COG1879	ABC-type sugar transport system periplasmic component
H5P29_RS06105	COG1802	Transcriptional regulator
H5P29_RS06110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5P29_RS06125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5P29_RS06135	COG0778	Nitroreductase
H5P29_RS06145	COG0179	Fumarylacetoacetate (FAA) hydrolase
H5P29_RS06160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5P29_RS06175	COG0840	transmembrane signaling receptor activity
H5P29_RS06175	COG2972	Histidine kinase
H5P29_RS06185	COG0601	transmembrane transport
H5P29_RS06190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS06200	COG1228	amidohydrolase
H5P29_RS06205	COG0444	Belongs to the ABC transporter superfamily
H5P29_RS06210	COG4608	Belongs to the ABC transporter superfamily
H5P29_RS06215	COG1802	Transcriptional regulator
H5P29_RS06220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5P29_RS06230	COG0402	S-adenosylhomocysteine deaminase activity
H5P29_RS06235	COG0747	negative chemotaxis
H5P29_RS06240	COG0402	S-adenosylhomocysteine deaminase activity
H5P29_RS06250	COG0747	negative chemotaxis
H5P29_RS06260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS06265	COG0601	transmembrane transport
H5P29_RS06270	COG1802	Transcriptional regulator
H5P29_RS06295	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS06300	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS06360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5P29_RS06370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H5P29_RS06385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H5P29_RS06390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5P29_RS06425	COG0010	Belongs to the arginase family
H5P29_RS06460	COG1176	ABC-type spermidine putrescine transport system, permease component I
H5P29_RS06470	COG3842	ATPase activity
H5P29_RS06475	COG0402	S-adenosylhomocysteine deaminase activity
H5P29_RS06490	COG0583	DNA-binding transcription factor activity
H5P29_RS06510	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5P29_RS06510	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H5P29_RS06530	COG3842	ATPase activity
H5P29_RS06540	COG1176	ABC-type spermidine putrescine transport system, permease component I
H5P29_RS06550	COG0583	DNA-binding transcription factor activity
H5P29_RS06580	COG0435	Glutathione S-transferase
H5P29_RS06610	COG5410	chromosome segregation
H5P29_RS06630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5P29_RS06645	COG0583	DNA-binding transcription factor activity
H5P29_RS06665	COG0583	DNA-binding transcription factor activity
H5P29_RS06675	COG3300	MHYT domain
H5P29_RS06675	COG5001	Diguanylate cyclase
H5P29_RS06685	COG4957	zinc ion binding
H5P29_RS06690	COG2199	diguanylate cyclase activity
H5P29_RS06725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H5P29_RS06735	COG0517	IMP dehydrogenase activity
H5P29_RS06740	COG4974	Belongs to the 'phage' integrase family
H5P29_RS06745	COG4957	zinc ion binding
H5P29_RS06775	COG0583	DNA-binding transcription factor activity
H5P29_RS06780	COG1136	(ABC) transporter
H5P29_RS06780	COG0577	efflux transmembrane transporter activity
H5P29_RS06785	COG1136	(ABC) transporter
H5P29_RS06835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5P29_RS06850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H5P29_RS06860	COG5425	PFAM Usg family protein
H5P29_RS06870	COG0071	Belongs to the small heat shock protein (HSP20) family
H5P29_RS06875	COG0071	Belongs to the small heat shock protein (HSP20) family
H5P29_RS06895	COG0583	DNA-binding transcription factor activity
H5P29_RS06900	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H5P29_RS06915	COG4521	taurine ABC transporter
H5P29_RS06920	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H5P29_RS06925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5P29_RS06930	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H5P29_RS06935	COG2855	membrane
H5P29_RS06985	COG1525	nuclease
H5P29_RS06990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5P29_RS07005	COG3081	Nucleoid-associated protein
H5P29_RS07065	COG1872	DUF167
H5P29_RS07075	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H5P29_RS07095	COG1704	LemA family
H5P29_RS07125	COG2814	Major facilitator Superfamily
H5P29_RS07130	COG1846	Transcriptional regulator
H5P29_RS07135	COG0339	signal peptide processing
H5P29_RS07145	COG1217	gtp-binding protein TYPA
H5P29_RS07165	COG2270	Major facilitator Superfamily
H5P29_RS07170	COG0138	bifunctional purine biosynthesis protein purh
H5P29_RS07180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H5P29_RS07180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H5P29_RS07185	COG0501	Belongs to the peptidase M48B family
H5P29_RS07210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H5P29_RS07215	COG0789	Transcriptional regulator
H5P29_RS07225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5P29_RS07230	COG5425	PFAM Usg family protein
H5P29_RS07240	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H5P29_RS07245	COG0495	leucyl-tRNA aminoacylation
H5P29_RS07255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H5P29_RS07265	COG1522	sequence-specific DNA binding
H5P29_RS07270	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H5P29_RS07290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H5P29_RS07300	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H5P29_RS07305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H5P29_RS07310	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H5P29_RS07315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H5P29_RS07320	COG0590	tRNA wobble adenosine to inosine editing
H5P29_RS07335	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H5P29_RS07345	COG1091	dTDP-4-dehydrorhamnose reductase activity
H5P29_RS07355	COG3754	Rhamnan synthesis protein F
H5P29_RS07380	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H5P29_RS07380	COG3743	rRNA binding
H5P29_RS07385	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H5P29_RS07400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H5P29_RS07405	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H5P29_RS07410	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H5P29_RS07415	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H5P29_RS07430	COG0799	negative regulation of ribosome biogenesis
H5P29_RS07435	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H5P29_RS07445	COG0793	Belongs to the peptidase S41A family
H5P29_RS07455	COG0494	nUDIX hydrolase
H5P29_RS07460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5P29_RS07470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5P29_RS07495	COG3655	Transcriptional regulator
H5P29_RS07520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5P29_RS07525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5P29_RS07565	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H5P29_RS07575	COG2223	nitrite transmembrane transporter activity
H5P29_RS07580	COG0583	DNA-binding transcription factor activity
H5P29_RS07595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5P29_RS07610	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS07620	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H5P29_RS07630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5P29_RS07650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H5P29_RS07655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H5P29_RS07670	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H5P29_RS07675	COG0183	Belongs to the thiolase family
H5P29_RS07680	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS07685	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H5P29_RS07700	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H5P29_RS07705	COG1329	Transcriptional regulator
H5P29_RS07715	COG1126	abc transporter atp-binding protein
H5P29_RS07720	COG0765	amino acid transport
H5P29_RS07725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5P29_RS07730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H5P29_RS07740	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H5P29_RS07760	COG0488	(ABC) transporter
H5P29_RS07775	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H5P29_RS07785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5P29_RS07790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H5P29_RS07815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5P29_RS07830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5P29_RS07835	COG0037	tRNA processing
H5P29_RS07845	COG2885	chlorophyll binding
H5P29_RS07860	COG0848	biopolymer transport protein
H5P29_RS07870	COG0824	Thioesterase
H5P29_RS07875	COG2226	methyltransferase
H5P29_RS07885	COG1408	metallophosphoesterase
H5P29_RS07895	COG2255	four-way junction helicase activity
H5P29_RS07920	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H5P29_RS07940	COG0318	PFAM AMP-dependent synthetase and ligase
H5P29_RS07960	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H5P29_RS07965	COG0483	inositol monophosphate 1-phosphatase activity
H5P29_RS07970	COG1272	protein, Hemolysin III
H5P29_RS08020	COG0778	Nitroreductase
H5P29_RS08025	COG1132	(ABC) transporter
H5P29_RS08030	COG0254	rRNA binding
H5P29_RS08050	COG0702	epimerase
H5P29_RS08060	COG1181	Belongs to the D-alanine--D-alanine ligase family
H5P29_RS08070	COG0217	transcriptional regulatory protein
H5P29_RS08085	COG0625	glutathione transferase activity
H5P29_RS08090	COG1733	regulation of RNA biosynthetic process
H5P29_RS08115	COG0861	Integral membrane protein TerC family
H5P29_RS08120	COG1692	metallophosphoesterase
H5P29_RS08125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H5P29_RS08155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5P29_RS08175	COG0583	DNA-binding transcription factor activity
H5P29_RS08180	COG0431	NADPH-dependent FMN reductase
H5P29_RS08185	COG3750	Belongs to the UPF0335 family
H5P29_RS08205	COG0469	pyruvate kinase activity
H5P29_RS08210	COG2267	carboxylic ester hydrolase activity
H5P29_RS08215	COG0457	Tetratricopeptide repeat
H5P29_RS08220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H5P29_RS08225	COG3755	Protein conserved in bacteria
H5P29_RS08230	COG1733	regulation of RNA biosynthetic process
H5P29_RS08245	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H5P29_RS08265	COG0640	Transcriptional regulator
H5P29_RS08280	COG3321	synthase
H5P29_RS08280	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS08280	COG0604	alcohol dehydrogenase
H5P29_RS08285	COG2226	methyltransferase
H5P29_RS08295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5P29_RS08305	COG0145	ligase activity
H5P29_RS08310	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
H5P29_RS08340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5P29_RS08340	COG0045	succinate-CoA ligase (ADP-forming) activity
H5P29_RS08340	COG1042	CoA-binding domain protein
H5P29_RS08350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5P29_RS08355	COG0697	spore germination
H5P29_RS08370	COG0183	Belongs to the thiolase family
H5P29_RS08390	COG4191	Histidine kinase
H5P29_RS08415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5P29_RS08510	COG2268	Band 7 protein
H5P29_RS08525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H5P29_RS08595	COG3588	fructose-bisphosphate aldolase
H5P29_RS08605	COG0126	phosphoglycerate kinase activity
H5P29_RS08645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H5P29_RS08650	COG0564	pseudouridine synthase activity
H5P29_RS08660	COG0346	lactoylglutathione lyase activity
H5P29_RS08740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H5P29_RS08745	COG0573	inorganic phosphate transmembrane transporter activity
H5P29_RS08755	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H5P29_RS08760	COG0704	Plays a role in the regulation of phosphate uptake
H5P29_RS08765	COG0745	RESPONSE REGULATOR receiver
H5P29_RS08775	COG4213	ABC transporter substrate-binding protein
H5P29_RS08780	COG4214	carbohydrate transport
H5P29_RS08805	COG2202	Pas domain
H5P29_RS08805	COG3920	Histidine kinase
H5P29_RS08815	COG0784	Response regulator, receiver
H5P29_RS08830	COG0784	Response regulator, receiver
H5P29_RS08835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5P29_RS08840	COG0628	permease
H5P29_RS08875	COG0346	lactoylglutathione lyase activity
H5P29_RS08880	COG0400	carboxylic ester hydrolase activity
H5P29_RS08900	COG2199	diguanylate cyclase activity
H5P29_RS08900	COG2203	Gaf domain
H5P29_RS08900	COG2200	EAL domain
H5P29_RS08905	COG0745	RESPONSE REGULATOR receiver
H5P29_RS08910	COG0745	RESPONSE REGULATOR receiver
H5P29_RS08925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5P29_RS08930	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H5P29_RS08935	COG3833	ABC-type maltose transport systems, permease component
H5P29_RS08940	COG3842	ATPase activity
H5P29_RS08960	COG0483	inositol monophosphate 1-phosphatase activity
H5P29_RS08965	COG0483	inositol monophosphate 1-phosphatase activity
H5P29_RS08990	COG1840	ABC-type Fe3 transport system, periplasmic component
H5P29_RS09000	COG3842	ATPase activity
H5P29_RS09005	COG1238	metal cluster binding
H5P29_RS09015	COG2132	Multicopper oxidase
H5P29_RS09050	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H5P29_RS09055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H5P29_RS09065	COG1845	cytochrome c oxidase, subunit III
H5P29_RS09080	COG0406	alpha-ribazole phosphatase activity
H5P29_RS09085	COG3842	ATPase activity
H5P29_RS09090	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H5P29_RS09110	COG1737	Transcriptional regulator
H5P29_RS09120	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS09135	COG0395	ABC-type sugar transport system, permease component
H5P29_RS09145	COG1079	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS09150	COG4603	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS09155	COG3845	ABC transporter
H5P29_RS09165	COG2186	Transcriptional regulator
H5P29_RS09185	COG0625	glutathione transferase activity
H5P29_RS09190	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H5P29_RS09195	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H5P29_RS09200	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H5P29_RS09200	COG0352	thiamine-phosphate diphosphorylase activity
H5P29_RS09200	COG0351	phosphomethylpyrimidine kinase
H5P29_RS09210	COG2022	thiamine diphosphate biosynthetic process
H5P29_RS09225	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H5P29_RS09250	COG0356	it plays a direct role in the translocation of protons across the membrane
H5P29_RS09270	COG1473	amidohydrolase
H5P29_RS09275	COG1686	Belongs to the peptidase S11 family
H5P29_RS09280	COG0523	cobalamin synthesis protein
H5P29_RS09285	COG0425	Belongs to the sulfur carrier protein TusA family
H5P29_RS09295	COG0825	malonyl-CoA metabolic process
H5P29_RS09310	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H5P29_RS09315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H5P29_RS09320	COG4536	flavin adenine dinucleotide binding
H5P29_RS09375	COG1522	sequence-specific DNA binding
H5P29_RS09400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H5P29_RS09405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H5P29_RS09425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5P29_RS09430	COG2226	methyltransferase
H5P29_RS09445	COG1597	lipid kinase activity
H5P29_RS09450	COG2814	Major facilitator Superfamily
H5P29_RS09455	COG0583	DNA-binding transcription factor activity
H5P29_RS09460	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H5P29_RS09465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H5P29_RS09470	COG0287	Prephenate dehydrogenase
H5P29_RS09485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5P29_RS09485	COG2169	Transcriptional regulator
H5P29_RS09510	COG2884	Cell division ATP-binding protein ftsE
H5P29_RS09520	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H5P29_RS09535	COG0583	DNA-binding transcription factor activity
H5P29_RS09550	COG0019	diaminopimelate decarboxylase activity
H5P29_RS09560	COG0165	Argininosuccinate lyase
H5P29_RS09565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5P29_RS09570	COG1653	transport
H5P29_RS09575	COG1175	transmembrane transport
H5P29_RS09580	COG0395	ABC-type sugar transport system, permease component
H5P29_RS09585	COG3842	ATPase activity
H5P29_RS09595	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5P29_RS09600	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H5P29_RS09605	COG2086	electron transfer activity
H5P29_RS09625	COG0300	oxidoreductase activity
H5P29_RS09635	COG0697	spore germination
H5P29_RS09645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5P29_RS09665	COG1238	metal cluster binding
H5P29_RS09675	COG0583	DNA-binding transcription factor activity
H5P29_RS09695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5P29_RS09715	COG2239	Acts as a magnesium transporter
H5P29_RS09720	COG0653	protein targeting
H5P29_RS09725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5P29_RS09745	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H5P29_RS09750	COG0456	acetyltransferase
H5P29_RS09755	COG0494	nUDIX hydrolase
H5P29_RS09770	COG2226	methyltransferase
H5P29_RS09785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5P29_RS09810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5P29_RS09815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5P29_RS09820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5P29_RS09825	COG0527	aspartate kinase activity
H5P29_RS09835	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H5P29_RS09840	COG2890	protein-(glutamine-N5) methyltransferase activity
H5P29_RS09850	COG0542	response to heat
H5P29_RS09860	COG1376	ErfK ybiS ycfS ynhG family protein
H5P29_RS09885	COG0625	glutathione transferase activity
H5P29_RS09890	COG0477	Major facilitator Superfamily
H5P29_RS09895	COG0739	heme binding
H5P29_RS09895	COG1196	nuclear chromosome segregation
H5P29_RS09895	COG0741	lytic transglycosylase activity
H5P29_RS09940	COG4176	ABC-type proline glycine betaine transport system permease component
H5P29_RS09945	COG4175	Glycine betaine
H5P29_RS09945	COG3448	diguanylate cyclase activity
H5P29_RS09955	COG0745	RESPONSE REGULATOR receiver
H5P29_RS09960	COG2205	protein histidine kinase activity
H5P29_RS09970	COG0745	RESPONSE REGULATOR receiver
H5P29_RS09980	COG1879	ABC-type sugar transport system periplasmic component
H5P29_RS09985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H5P29_RS09995	COG3842	ATPase activity
H5P29_RS10015	COG1070	Carbohydrate kinase
H5P29_RS10025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H5P29_RS10030	COG0667	Aldo Keto reductase
H5P29_RS10040	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS10045	COG1129	ABC transporter
H5P29_RS10055	COG2358	TRAP transporter, solute receptor (TAXI family
H5P29_RS10065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5P29_RS10075	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H5P29_RS10115	COG0463	Glycosyl transferase, family 2
H5P29_RS10120	COG1215	transferase activity, transferring glycosyl groups
H5P29_RS10135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5P29_RS10140	COG1120	ATPase activity
H5P29_RS10145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5P29_RS10160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5P29_RS10165	COG0205	6-phosphofructokinase activity
H5P29_RS10170	COG1376	ErfK ybiS ycfS ynhG family protein
H5P29_RS10170	COG1388	LysM domain
H5P29_RS10175	COG1280	lysine exporter protein (LysE YggA)
H5P29_RS10185	COG1070	Carbohydrate kinase
H5P29_RS10195	COG2115	Belongs to the xylose isomerase family
H5P29_RS10215	COG4977	sequence-specific DNA binding
H5P29_RS10220	COG3246	L-lysine catabolic process to acetate
H5P29_RS10225	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5P29_RS10230	COG1960	acyl-CoA dehydrogenase activity
H5P29_RS10245	COG0657	acetylesterase activity
H5P29_RS10255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS10280	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H5P29_RS10285	COG3257	ureidoglycine aminohydrolase activity
H5P29_RS10295	COG2351	hydroxyisourate hydrolase activity
H5P29_RS10305	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H5P29_RS10315	COG0783	Belongs to the Dps family
H5P29_RS10330	COG0583	DNA-binding transcription factor activity
H5P29_RS10340	COG0402	S-adenosylhomocysteine deaminase activity
H5P29_RS10345	COG4702	Belongs to the UPF0303 family
H5P29_RS10365	COG0174	glutamine synthetase
H5P29_RS10395	COG0523	cobalamin synthesis protein
H5P29_RS10405	COG1846	Transcriptional regulator
H5P29_RS10420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5P29_RS10435	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H5P29_RS10440	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H5P29_RS10445	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H5P29_RS10460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H5P29_RS10460	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H5P29_RS10490	COG5001	Diguanylate cyclase
H5P29_RS10530	COG1280	lysine exporter protein (LysE YggA)
H5P29_RS10540	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5P29_RS10550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H5P29_RS10570	COG2223	nitrite transmembrane transporter activity
H5P29_RS10580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5P29_RS10595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H5P29_RS10595	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5P29_RS10655	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H5P29_RS10695	COG3842	ATPase activity
H5P29_RS10700	COG0583	DNA-binding transcription factor activity
H5P29_RS10705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H5P29_RS10710	COG3842	ATPase activity
H5P29_RS10715	COG1176	ABC-type spermidine putrescine transport system, permease component I
H5P29_RS10720	COG1177	transmembrane transport
H5P29_RS10725	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS10740	COG1609	Transcriptional regulator
H5P29_RS10755	COG1024	Enoyl-CoA hydratase
H5P29_RS10760	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS10765	COG1653	transport
H5P29_RS10775	COG0395	ABC-type sugar transport system, permease component
H5P29_RS10780	COG3842	ATPase activity
H5P29_RS10790	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS10800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5P29_RS10805	COG3774	pathogenesis
H5P29_RS10810	COG4608	Belongs to the ABC transporter superfamily
H5P29_RS10815	COG0402	S-adenosylhomocysteine deaminase activity
H5P29_RS10820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS10830	COG4533	DNA binding
H5P29_RS10835	COG0444	Belongs to the ABC transporter superfamily
H5P29_RS10865	COG2072	flavoprotein involved in K transport
H5P29_RS10895	COG0071	Belongs to the small heat shock protein (HSP20) family
H5P29_RS10905	COG0069	glutamate synthase activity
H5P29_RS10905	COG0070	glutamate synthase
H5P29_RS10905	COG0067	glutamate synthase
H5P29_RS10925	COG2951	lytic endotransglycosylase activity
H5P29_RS10930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H5P29_RS10935	COG0778	Nitroreductase
H5P29_RS10960	COG1585	Membrane protein implicated in regulation of membrane protease activity
H5P29_RS10965	COG0330	HflC and HflK could
H5P29_RS10970	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H5P29_RS10970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5P29_RS10975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H5P29_RS10980	COG0737	Belongs to the 5'-nucleotidase family
H5P29_RS10990	COG3775	system Galactitol-specific IIC component
H5P29_RS11010	COG5310	Homospermidine synthase
H5P29_RS11040	COG2204	response regulator
H5P29_RS11045	COG3108	Peptidase M15
H5P29_RS11050	COG0800	Aldolase
H5P29_RS11060	COG1054	Belongs to the UPF0176 family
H5P29_RS11070	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS11130	COG0583	DNA-binding transcription factor activity
H5P29_RS11135	COG0154	amidase activity
H5P29_RS11185	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H5P29_RS11190	COG2814	Major facilitator Superfamily
H5P29_RS11200	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H5P29_RS11205	COG5443	negative regulation of bacterial-type flagellum assembly
H5P29_RS11210	COG5442	Flagellar protein FlaF
H5P29_RS11225	COG1749	Flagellar hook protein flgE
H5P29_RS11265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5P29_RS11270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5P29_RS11275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5P29_RS11285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5P29_RS11290	COG1338	Plays a role in the flagellum-specific transport system
H5P29_RS11300	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H5P29_RS11310	COG1706	bacterial-type flagellum-dependent cell motility
H5P29_RS11315	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
H5P29_RS11320	COG4786	Flagellar basal body rod
H5P29_RS11325	COG1677	Flagellar hook-basal body complex protein FliE
H5P29_RS11330	COG1558	bacterial-type flagellum-dependent cell motility
H5P29_RS11335	COG1815	bacterial-type flagellum-dependent cell motility
H5P29_RS11345	COG1157	protein secretion by the type III secretion system
H5P29_RS11350	COG4786	Flagellar basal body rod
H5P29_RS11360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H5P29_RS11370	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H5P29_RS11375	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H5P29_RS11380	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H5P29_RS11395	COG2771	luxR family
H5P29_RS11410	COG1309	transcriptional regulator
H5P29_RS11415	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H5P29_RS11420	COG3842	ATPase activity
H5P29_RS11430	COG1177	transmembrane transport
H5P29_RS11460	COG4213	ABC transporter substrate-binding protein
H5P29_RS11465	COG1129	ABC transporter
H5P29_RS11470	COG4214	carbohydrate transport
H5P29_RS11520	COG1129	ABC transporter
H5P29_RS11525	COG4211	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS11530	COG0673	inositol 2-dehydrogenase activity
H5P29_RS11535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5P29_RS11540	COG3962	Belongs to the TPP enzyme family
H5P29_RS11545	COG1082	Xylose isomerase domain protein TIM barrel
H5P29_RS11555	COG3718	enzyme involved in inositol metabolism
H5P29_RS11560	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H5P29_RS11595	COG2197	response regulator
H5P29_RS11615	COG0747	negative chemotaxis
H5P29_RS11640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5P29_RS11645	COG0747	negative chemotaxis
H5P29_RS11660	COG3454	Phosphonate metabolism
H5P29_RS11665	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H5P29_RS11670	COG3639	organic phosphonate transmembrane transporter activity
H5P29_RS11685	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H5P29_RS11690	COG1733	regulation of RNA biosynthetic process
H5P29_RS11705	COG0786	glutamate:sodium symporter activity
H5P29_RS11715	COG4778	phosphonate C-P lyase system protein PhnL
H5P29_RS11720	COG4107	phosphonate C-P lyase system protein PhnK
H5P29_RS11725	COG3627	carbon phosphorus lyase activity
H5P29_RS11730	COG3626	phosphonate metabolism
H5P29_RS11735	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
H5P29_RS11740	COG3624	Phosphonate C-P lyase system protein PhnG
H5P29_RS11745	COG2188	Transcriptional regulator
H5P29_RS11760	COG1177	transmembrane transport
H5P29_RS11770	COG2072	flavoprotein involved in K transport
H5P29_RS11785	COG3620	sequence-specific DNA binding
H5P29_RS11815	COG0583	DNA-binding transcription factor activity
H5P29_RS11825	COG3842	ATPase activity
H5P29_RS11835	COG1175	transmembrane transport
H5P29_RS11870	COG0482	sulfurtransferase activity
H5P29_RS11885	COG0604	alcohol dehydrogenase
H5P29_RS11890	COG1733	regulation of RNA biosynthetic process
H5P29_RS11905	COG2201	protein-glutamate methylesterase activity
H5P29_RS11950	COG0435	Glutathione S-transferase
H5P29_RS11955	COG0494	nUDIX hydrolase
H5P29_RS11970	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5P29_RS11970	COG0596	Alpha beta hydrolase
H5P29_RS11980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H5P29_RS11990	COG3180	Ammonia monooxygenase
H5P29_RS12020	COG0512	Glutamine amidotransferase of anthranilate synthase
H5P29_RS12020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H5P29_RS12025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5P29_RS12035	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H5P29_RS12040	COG2814	Major facilitator Superfamily
H5P29_RS12045	COG0583	DNA-binding transcription factor activity
H5P29_RS12050	COG4993	Dehydrogenase
H5P29_RS12060	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H5P29_RS12080	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H5P29_RS12110	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H5P29_RS12145	COG1435	thymidine kinase activity
H5P29_RS12155	COG4176	ABC-type proline glycine betaine transport system permease component
H5P29_RS12160	COG3448	diguanylate cyclase activity
H5P29_RS12160	COG4175	Glycine betaine
H5P29_RS12180	COG5507	3-demethylubiquinone-9 3-methyltransferase
H5P29_RS12185	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H5P29_RS12210	COG1278	Cold shock
H5P29_RS12235	COG0714	Associated with various cellular activities
H5P29_RS12245	COG0494	nUDIX hydrolase
H5P29_RS12270	COG0408	coproporphyrinogen oxidase activity
H5P29_RS12300	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H5P29_RS12310	COG1132	(ABC) transporter
H5P29_RS12315	COG1132	(ABC) transporter
H5P29_RS12320	COG1132	(ABC) transporter
H5P29_RS12340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H5P29_RS12340	COG2857	Cytochrome c1
H5P29_RS12345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H5P29_RS12375	COG0012	GTP binding
H5P29_RS12380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H5P29_RS12385	COG0193	aminoacyl-tRNA hydrolase activity
H5P29_RS12390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H5P29_RS12410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H5P29_RS12425	COG1496	oxidoreductase activity
H5P29_RS12435	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H5P29_RS12450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5P29_RS12460	COG1464	Belongs to the NlpA lipoprotein family
H5P29_RS12465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H5P29_RS12470	COG2011	ABC-type metal ion transport system permease component
H5P29_RS12475	COG2205	protein histidine kinase activity
H5P29_RS12485	COG0745	RESPONSE REGULATOR receiver
H5P29_RS12490	COG1846	Transcriptional regulator
H5P29_RS12495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H5P29_RS12505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5P29_RS12515	COG1278	Cold shock
H5P29_RS12525	COG1278	Cold shock
H5P29_RS12540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5P29_RS12545	COG0583	DNA-binding transcription factor activity
H5P29_RS12560	COG1819	glycosyl
H5P29_RS12565	COG1309	transcriptional regulator
H5P29_RS12570	COG1794	racemase activity, acting on amino acids and derivatives
H5P29_RS12580	COG3791	Glutathione-dependent formaldehyde-activating
H5P29_RS12585	COG0726	polysaccharide deacetylase
H5P29_RS12605	COG1396	sequence-specific DNA binding
H5P29_RS12635	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5P29_RS12645	COG1522	sequence-specific DNA binding
H5P29_RS12660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5P29_RS12680	COG0583	DNA-binding transcription factor activity
H5P29_RS12695	COG0556	nucleotide-excision repair
H5P29_RS12705	COG0438	transferase activity, transferring glycosyl groups
H5P29_RS12735	COG1597	lipid kinase activity
H5P29_RS12745	COG2084	Dehydrogenase
H5P29_RS12750	COG4948	Mandelate Racemase Muconate Lactonizing
H5P29_RS12775	COG1253	flavin adenine dinucleotide binding
H5P29_RS12820	COG0583	DNA-binding transcription factor activity
H5P29_RS12830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5P29_RS12840	COG2133	pyrroloquinoline quinone binding
H5P29_RS12845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5P29_RS12860	COG3306	glycosyltransferase involved in LPS biosynthesis
H5P29_RS12865	COG3306	glycosyltransferase involved in LPS biosynthesis
H5P29_RS12875	COG1522	sequence-specific DNA binding
H5P29_RS12880	COG0492	ferredoxin-NADP+ reductase activity
H5P29_RS12885	COG0583	DNA-binding transcription factor activity
H5P29_RS12890	COG0640	Transcriptional regulator
H5P29_RS12915	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H5P29_RS12920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H5P29_RS12935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H5P29_RS12945	COG0477	Major facilitator Superfamily
H5P29_RS12985	COG0436	Aminotransferase
H5P29_RS13005	COG1278	Cold shock
H5P29_RS13015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5P29_RS13040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H5P29_RS13050	COG2130	NADP-dependent
H5P29_RS13060	COG3591	Belongs to the peptidase S1B family
H5P29_RS13060	COG1864	DNA RNA non-specific endonuclease
H5P29_RS13075	COG2814	Major facilitator Superfamily
H5P29_RS13085	COG0318	PFAM AMP-dependent synthetase and ligase
H5P29_RS13095	COG2321	neutral zinc metallopeptidase
H5P29_RS13100	COG4989	oxidoreductase activity
H5P29_RS13135	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5P29_RS13135	COG0596	Alpha beta hydrolase
H5P29_RS13140	COG0505	Belongs to the CarA family
H5P29_RS13155	COG1473	amidohydrolase
H5P29_RS13165	COG0358	DNA primase activity
H5P29_RS13170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H5P29_RS13185	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
H5P29_RS13200	COG0372	Belongs to the citrate synthase family
H5P29_RS13205	COG0372	Belongs to the citrate synthase family
H5P29_RS13245	COG1280	lysine exporter protein (LysE YggA)
H5P29_RS13290	COG0488	(ABC) transporter
H5P29_RS13305	COG1522	sequence-specific DNA binding
H5P29_RS13315	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H5P29_RS13320	COG0583	DNA-binding transcription factor activity
H5P29_RS13325	COG1309	transcriptional regulator
H5P29_RS13355	COG2862	Uncharacterized protein family, UPF0114
H5P29_RS13365	COG2983	Belongs to the UPF0260 family
H5P29_RS13375	COG2968	Membrane
H5P29_RS13500	COG1372	Participates in initiation and elongation during chromosome replication
H5P29_RS13500	COG0305	Participates in initiation and elongation during chromosome replication
H5P29_RS13740	COG1760	l-serine dehydratase
H5P29_RS13745	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H5P29_RS13745	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H5P29_RS13750	COG0509	glycine decarboxylation via glycine cleavage system
H5P29_RS13755	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H5P29_RS13765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H5P29_RS13770	COG0583	DNA-binding transcription factor activity
H5P29_RS13775	COG1309	transcriptional regulator
H5P29_RS13780	COG1744	ABC transporter substrate-binding protein PnrA-like
H5P29_RS13785	COG3845	ABC transporter
H5P29_RS13790	COG4603	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS13795	COG1079	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS13800	COG0010	Belongs to the arginase family
H5P29_RS13815	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS13820	COG1414	Transcriptional regulator
H5P29_RS13825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5P29_RS13830	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H5P29_RS13845	COG1309	transcriptional regulator
H5P29_RS13850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H5P29_RS13865	COG1609	Transcriptional regulator
H5P29_RS13865	COG2207	Transcriptional regulator
H5P29_RS13870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5P29_RS13885	COG1609	Transcriptional regulator
H5P29_RS13890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5P29_RS13900	COG0765	amino acid transport
H5P29_RS13910	COG0010	Belongs to the arginase family
H5P29_RS13915	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS13955	COG3842	ATPase activity
H5P29_RS13960	COG1082	Xylose isomerase domain protein TIM barrel
H5P29_RS13980	COG2814	Major facilitator Superfamily
H5P29_RS13990	COG4608	Belongs to the ABC transporter superfamily
H5P29_RS13995	COG0444	Belongs to the ABC transporter superfamily
H5P29_RS14000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS14005	COG0601	transmembrane transport
H5P29_RS14010	COG0747	negative chemotaxis
H5P29_RS14025	COG1473	amidohydrolase
H5P29_RS14030	COG1473	amidohydrolase
H5P29_RS14035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5P29_RS14040	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS14050	COG5383	Protein conserved in bacteria
H5P29_RS14060	COG1737	Transcriptional regulator
H5P29_RS14060	COG0837	glucose binding
H5P29_RS14070	COG0601	transmembrane transport
H5P29_RS14075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS14080	COG0444	Belongs to the ABC transporter superfamily
H5P29_RS14105	COG3706	GGDEF domain
H5P29_RS14120	COG0463	Glycosyl transferase, family 2
H5P29_RS14175	COG0367	asparagine synthase
H5P29_RS14185	COG0318	PFAM AMP-dependent synthetase and ligase
H5P29_RS14190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H5P29_RS14225	COG1902	pentaerythritol trinitrate reductase activity
H5P29_RS14245	COG0673	inositol 2-dehydrogenase activity
H5P29_RS14255	COG0589	response to stress
H5P29_RS14260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5P29_RS14265	COG4597	amino acid ABC transporter
H5P29_RS14270	COG0765	amino acid transport
H5P29_RS14280	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H5P29_RS14285	COG4208	sulfate ABC transporter
H5P29_RS14290	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H5P29_RS14295	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H5P29_RS14315	COG4953	penicillin-binding protein 1C
H5P29_RS14325	COG0729	surface antigen
H5P29_RS14335	COG4166	transmembrane transport
H5P29_RS14340	COG0601	transmembrane transport
H5P29_RS14345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS14355	COG0493	'glutamate synthase
H5P29_RS14380	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H5P29_RS14395	COG1309	transcriptional regulator
H5P29_RS14400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H5P29_RS14425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5P29_RS14430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5P29_RS14455	COG0028	Belongs to the TPP enzyme family
H5P29_RS14460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H5P29_RS14465	COG2267	carboxylic ester hydrolase activity
H5P29_RS14470	COG1131	(ABC) transporter
H5P29_RS14475	COG0842	Transport permease protein
H5P29_RS14510	COG4106	trans-aconitate 2-methyltransferase activity
H5P29_RS14525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H5P29_RS14530	COG1522	sequence-specific DNA binding
H5P29_RS14540	COG1720	tRNA m6t6A37 methyltransferase activity
H5P29_RS14565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5P29_RS14605	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H5P29_RS14625	COG0626	cystathionine gamma-synthase activity
H5P29_RS14630	COG2001	Belongs to the MraZ family
H5P29_RS14635	COG0275	rRNA processing
H5P29_RS14650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H5P29_RS14660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H5P29_RS14665	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H5P29_RS14675	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H5P29_RS14680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5P29_RS14685	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H5P29_RS14690	COG1181	Belongs to the D-alanine--D-alanine ligase family
H5P29_RS14695	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H5P29_RS14700	COG0849	cell division
H5P29_RS14705	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H5P29_RS14715	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5P29_RS14745	COG0006	proline dipeptidase activity
H5P29_RS14750	COG2264	protein methyltransferase activity
H5P29_RS14755	COG1999	signal sequence binding
H5P29_RS14790	COG5002	protein histidine kinase activity
H5P29_RS14810	COG0210	DNA helicase
H5P29_RS14835	COG0277	FAD linked oxidase domain protein
H5P29_RS14880	COG2814	Major facilitator Superfamily
H5P29_RS14885	COG3706	GGDEF domain
H5P29_RS14910	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H5P29_RS14925	COG0330	HflC and HflK could
H5P29_RS14930	COG0330	HflC and HflK could
H5P29_RS14940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5P29_RS14950	COG3830	Belongs to the UPF0237 family
H5P29_RS14950	COG0560	Phosphoserine phosphatase
H5P29_RS14955	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H5P29_RS14965	COG2267	carboxylic ester hydrolase activity
H5P29_RS14975	COG1132	(ABC) transporter
H5P29_RS14980	COG0028	Belongs to the TPP enzyme family
H5P29_RS14985	COG0440	acetolactate synthase activity
H5P29_RS15040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H5P29_RS15065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H5P29_RS15070	COG3158	transport of potassium into the cell
H5P29_RS15075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5P29_RS15095	COG0583	DNA-binding transcription factor activity
H5P29_RS15100	COG1309	transcriptional regulator
H5P29_RS15105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H5P29_RS15135	COG0577	efflux transmembrane transporter activity
H5P29_RS15135	COG1136	(ABC) transporter
H5P29_RS15140	COG1136	(ABC) transporter
H5P29_RS15140	COG0577	efflux transmembrane transporter activity
H5P29_RS15150	COG0384	phenazine biosynthesis protein PhzF
H5P29_RS15165	COG0628	permease
H5P29_RS15185	COG1959	2 iron, 2 sulfur cluster binding
H5P29_RS15190	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H5P29_RS15195	COG4208	sulfate ABC transporter
H5P29_RS15210	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H5P29_RS15215	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H5P29_RS15220	COG1797	cobyrinic acid a,c-diamide synthase activity
H5P29_RS15230	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
H5P29_RS15290	COG3214	Protein conserved in bacteria
H5P29_RS15295	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5P29_RS15300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5P29_RS15305	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5P29_RS15310	COG0649	NAD binding
H5P29_RS15315	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H5P29_RS15320	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H5P29_RS15325	COG3743	rRNA binding
H5P29_RS15325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H5P29_RS15335	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H5P29_RS15340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5P29_RS15350	COG0713	ATP synthesis coupled electron transport
H5P29_RS15365	COG1007	ATP synthesis coupled electron transport
H5P29_RS15380	COG0346	lactoylglutathione lyase activity
H5P29_RS15390	COG0442	prolyl-tRNA aminoacylation
H5P29_RS15400	COG1136	(ABC) transporter
H5P29_RS15405	COG0442	prolyl-tRNA aminoacylation
H5P29_RS15415	COG0321	lipoyl(octanoyl) transferase activity
H5P29_RS15440	COG0789	Transcriptional regulator
H5P29_RS15445	COG2239	Acts as a magnesium transporter
H5P29_RS15525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5P29_RS15555	COG0583	DNA-binding transcription factor activity
H5P29_RS15575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H5P29_RS15575	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5P29_RS15585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5P29_RS15590	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H5P29_RS15590	COG3264	Mechanosensitive ion channel
H5P29_RS15615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5P29_RS15680	COG0583	DNA-binding transcription factor activity
H5P29_RS15705	COG1410	methionine synthase
H5P29_RS15705	COG0646	methionine synthase
H5P29_RS15725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H5P29_RS15730	COG3932	Exopolysaccharide synthesis, ExoD
H5P29_RS15750	COG5012	cobalamin binding
H5P29_RS15755	COG5598	trimethylamine methyltransferase
H5P29_RS15765	COG2186	Transcriptional regulator
H5P29_RS15770	COG2807	transmembrane transport
H5P29_RS15780	COG2081	HI0933 family
H5P29_RS15795	COG2304	oxidoreductase activity
H5P29_RS15815	COG0646	methionine synthase
H5P29_RS15815	COG1410	methionine synthase
H5P29_RS15845	COG0006	proline dipeptidase activity
H5P29_RS15855	COG5598	trimethylamine methyltransferase
H5P29_RS15890	COG1960	acyl-CoA dehydrogenase activity
H5P29_RS15900	COG1492	cobalamin metabolic process
H5P29_RS15925	COG4172	Belongs to the ABC transporter superfamily
H5P29_RS15930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS15935	COG0601	transmembrane transport
H5P29_RS15940	COG0747	negative chemotaxis
H5P29_RS15945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5P29_RS15970	COG0243	molybdopterin cofactor binding
H5P29_RS15975	COG0437	4 iron, 4 sulfur cluster binding
H5P29_RS15980	COG3302	dmso reductase anchor subunit
H5P29_RS15985	COG1560	Kdo2-lipid A biosynthetic process
H5P29_RS15995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5P29_RS16005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5P29_RS16035	COG1522	sequence-specific DNA binding
H5P29_RS16065	COG1629	transport
H5P29_RS16075	COG3720	iron ion transport
H5P29_RS16085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5P29_RS16090	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H5P29_RS16095	COG1959	2 iron, 2 sulfur cluster binding
H5P29_RS16110	COG1309	transcriptional regulator
H5P29_RS16120	COG2733	membrane
H5P29_RS16170	COG2832	Protein of unknown function (DUF454)
H5P29_RS16175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5P29_RS16180	COG2205	protein histidine kinase activity
H5P29_RS16225	COG2205	protein histidine kinase activity
H5P29_RS16230	COG1525	nuclease
H5P29_RS16235	COG0625	glutathione transferase activity
H5P29_RS16240	COG1573	uracil-dna glycosylase
H5P29_RS16245	COG1522	sequence-specific DNA binding
H5P29_RS16255	COG2084	Dehydrogenase
H5P29_RS16275	COG1763	Mo-molybdopterin cofactor biosynthetic process
H5P29_RS16280	COG0746	molybdenum cofactor guanylyltransferase activity
H5P29_RS16300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H5P29_RS16320	COG1846	Transcriptional regulator
H5P29_RS16325	COG0596	Alpha beta hydrolase
H5P29_RS16345	COG2989	Protein conserved in bacteria
H5P29_RS16365	COG0546	phosphoglycolate phosphatase activity
H5P29_RS16370	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H5P29_RS16385	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H5P29_RS16390	COG2199	diguanylate cyclase activity
H5P29_RS16395	COG2514	catechol 2,3-dioxygenase activity
H5P29_RS16405	COG0659	secondary active sulfate transmembrane transporter activity
H5P29_RS16410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H5P29_RS16435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5P29_RS16455	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H5P29_RS16455	COG3608	succinylglutamate desuccinylase aspartoacylase
H5P29_RS16460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H5P29_RS16530	COG0583	DNA-binding transcription factor activity
H5P29_RS16535	COG2855	membrane
H5P29_RS16560	COG0850	regulation of cytokinetic process
H5P29_RS16565	COG2894	cell division
H5P29_RS16570	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H5P29_RS16580	COG2267	carboxylic ester hydrolase activity
H5P29_RS16610	COG1607	acyl-coa hydrolase
H5P29_RS16615	COG0251	oxidation-reduction process
H5P29_RS16635	COG0071	Belongs to the small heat shock protein (HSP20) family
H5P29_RS16695	COG0459	protein refolding
H5P29_RS16710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H5P29_RS16715	COG2235	arginine
H5P29_RS16745	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H5P29_RS16785	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H5P29_RS16820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5P29_RS16835	COG2205	protein histidine kinase activity
H5P29_RS16840	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5P29_RS16865	COG0586	Pfam SNARE associated Golgi protein
H5P29_RS16880	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H5P29_RS16890	COG1136	(ABC) transporter
H5P29_RS16905	COG5622	Protein required for attachment to host cells
H5P29_RS16910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5P29_RS16920	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H5P29_RS16930	COG1546	Belongs to the CinA family
H5P29_RS16930	COG1058	Belongs to the CinA family
H5P29_RS16940	COG0596	Alpha beta hydrolase
H5P29_RS16965	COG2267	carboxylic ester hydrolase activity
H5P29_RS16990	COG4191	Histidine kinase
H5P29_RS16995	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H5P29_RS17005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5P29_RS17010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H5P29_RS17025	COG1278	Cold shock
H5P29_RS17045	COG1024	Enoyl-CoA hydratase
H5P29_RS17090	COG0517	IMP dehydrogenase activity
H5P29_RS17090	COG0516	GMP reductase activity
H5P29_RS17095	COG3811	Belongs to the UPF0386 family
H5P29_RS17105	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H5P29_RS17115	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H5P29_RS17120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H5P29_RS17145	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H5P29_RS17150	COG0439	Biotin carboxylase
H5P29_RS17155	COG0511	ligase activity, forming carbon-carbon bonds
H5P29_RS17160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H5P29_RS17175	COG0436	Aminotransferase
H5P29_RS17200	COG2066	Belongs to the glutaminase family
H5P29_RS17235	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H5P29_RS17250	COG0525	valine-tRNA ligase activity
H5P29_RS17265	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H5P29_RS17270	COG0708	Exodeoxyribonuclease III
H5P29_RS17280	COG2233	PERMEase
H5P29_RS17295	COG0316	Belongs to the HesB IscA family
H5P29_RS17300	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H5P29_RS17305	COG0018	arginyl-trna synthetase
H5P29_RS17320	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H5P29_RS17325	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H5P29_RS17330	COG3842	ATPase activity
H5P29_RS17335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5P29_RS17340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5P29_RS17345	COG0805	protein transport
H5P29_RS17350	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H5P29_RS17355	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H5P29_RS17360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H5P29_RS17375	COG1862	Preprotein translocase
H5P29_RS17405	COG0519	Catalyzes the synthesis of GMP from XMP
H5P29_RS17410	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H5P29_RS17535	COG4712	double-strand break repair protein
H5P29_RS17640	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H5P29_RS17680	COG1783	phage Terminase large subunit
H5P29_RS17815	COG0544	peptidyl-prolyl cis-trans isomerase activity
H5P29_RS17820	COG2003	Belongs to the UPF0758 family
H5P29_RS17825	COG0024	Methionine aminopeptidase
H5P29_RS17835	COG2824	Alkylphosphonate utilization operon protein PhnA
H5P29_RS17840	COG1609	Transcriptional regulator
H5P29_RS17850	COG1175	transmembrane transport
H5P29_RS17855	COG0395	ABC-type sugar transport system, permease component
H5P29_RS17870	COG3842	ATPase activity
H5P29_RS17890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5P29_RS17895	COG1116	anion transmembrane transporter activity
H5P29_RS17900	COG4149	molybdate abc transporter
H5P29_RS17915	COG2197	response regulator
H5P29_RS17975	COG3243	poly(R)-hydroxyalkanoic acid synthase
H5P29_RS17985	COG0436	Aminotransferase
H5P29_RS17995	COG1494	fructose-1,6-bisphosphatase
H5P29_RS18000	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H5P29_RS18005	COG1752	Esterase of the alpha-beta hydrolase superfamily
H5P29_RS18010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H5P29_RS18015	COG0302	gtp cyclohydrolase
H5P29_RS18025	COG0583	DNA-binding transcription factor activity
H5P29_RS18035	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H5P29_RS18045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H5P29_RS18060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5P29_RS18065	COG2301	Belongs to the HpcH HpaI aldolase family
H5P29_RS18080	COG0187	DNA topoisomerase II activity
H5P29_RS18090	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H5P29_RS18090	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H5P29_RS18095	COG0509	glycine decarboxylation via glycine cleavage system
H5P29_RS18100	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H5P29_RS18110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H5P29_RS18125	COG1671	Belongs to the UPF0178 family
H5P29_RS18135	COG2153	protein acetylation
H5P29_RS18140	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H5P29_RS18150	COG4941	Belongs to the sigma-70 factor family
H5P29_RS18155	COG3795	YCII-related domain
H5P29_RS18175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H5P29_RS18190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5P29_RS18190	COG0475	glutathione-regulated potassium exporter activity
H5P29_RS18205	COG3768	UPF0283 membrane protein
H5P29_RS18210	COG3106	COG3106 Predicted ATPase
H5P29_RS18245	COG0513	Belongs to the DEAD box helicase family
H5P29_RS18255	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS18265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H5P29_RS18270	COG2897	thiosulfate sulfurtransferase activity
H5P29_RS18285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H5P29_RS18300	COG0686	Belongs to the AlaDH PNT family
H5P29_RS18305	COG1522	sequence-specific DNA binding
H5P29_RS18310	COG0737	Belongs to the 5'-nucleotidase family
H5P29_RS18320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H5P29_RS18330	COG4957	zinc ion binding
H5P29_RS18335	COG1530	ribonuclease E activity
H5P29_RS18340	COG0860	N-Acetylmuramoyl-L-alanine amidase
H5P29_RS18345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H5P29_RS18370	COG2885	chlorophyll binding
H5P29_RS18375	COG0513	Belongs to the DEAD box helicase family
H5P29_RS18380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H5P29_RS18390	COG3706	GGDEF domain
H5P29_RS18405	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H5P29_RS18415	COG1414	Transcriptional regulator
H5P29_RS18420	COG3960	tartronate-semialdehyde synthase activity
H5P29_RS18425	COG3622	Belongs to the hyi family
H5P29_RS18430	COG2084	Dehydrogenase
H5P29_RS18440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5P29_RS18455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H5P29_RS18480	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H5P29_RS18490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H5P29_RS18495	COG0081	regulation of translation
H5P29_RS18500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H5P29_RS18505	COG0222	ribosome binding
H5P29_RS18510	COG0085	RNA polymerase activity
H5P29_RS18515	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H5P29_RS18525	COG0531	amino acid
H5P29_RS18535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H5P29_RS18540	COG0049	tRNA binding
H5P29_RS18545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H5P29_RS18550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H5P29_RS18555	COG0051	transcription antitermination factor activity, RNA binding
H5P29_RS18560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H5P29_RS18565	COG0088	Forms part of the polypeptide exit tunnel
H5P29_RS18570	COG0089	rRNA binding
H5P29_RS18575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H5P29_RS18580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H5P29_RS18585	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H5P29_RS18590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H5P29_RS18595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H5P29_RS18600	COG0255	Belongs to the universal ribosomal protein uL29 family
H5P29_RS18605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H5P29_RS18610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H5P29_RS18615	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H5P29_RS18620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H5P29_RS18625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H5P29_RS18630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H5P29_RS18635	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H5P29_RS18640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H5P29_RS18645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H5P29_RS18650	COG1841	ribosomal large subunit assembly
H5P29_RS18655	COG0200	Binds to the 23S rRNA
H5P29_RS18665	COG0563	adenylate kinase activity
H5P29_RS18670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H5P29_RS18675	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H5P29_RS18680	COG0202	RNA polymerase activity
H5P29_RS18685	COG0203	ribosomal protein L17
H5P29_RS18695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H5P29_RS18700	COG0640	Transcriptional regulator
H5P29_RS18730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H5P29_RS18730	COG0321	lipoyl(octanoyl) transferase activity
H5P29_RS18735	COG0084	hydrolase, TatD family'
H5P29_RS18750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H5P29_RS18755	COG1686	Belongs to the peptidase S11 family
H5P29_RS18785	COG3706	GGDEF domain
H5P29_RS18795	COG0708	Exodeoxyribonuclease III
H5P29_RS18810	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H5P29_RS18825	COG0583	DNA-binding transcription factor activity
H5P29_RS18830	COG0601	transmembrane transport
H5P29_RS18835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS18840	COG0444	Belongs to the ABC transporter superfamily
H5P29_RS18845	COG4608	Belongs to the ABC transporter superfamily
H5P29_RS18850	COG4166	transmembrane transport
H5P29_RS19010	COG0739	heme binding
H5P29_RS19020	COG0861	Integral membrane protein TerC family
H5P29_RS19025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5P29_RS19030	COG2814	Major facilitator Superfamily
H5P29_RS19065	COG1024	Enoyl-CoA hydratase
H5P29_RS19075	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS19085	COG1960	acyl-CoA dehydrogenase activity
H5P29_RS19095	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS19100	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS19115	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS19135	COG0183	Belongs to the thiolase family
H5P29_RS19140	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS19150	COG1960	acyl-CoA dehydrogenase activity
H5P29_RS19165	COG1024	Enoyl-CoA hydratase
H5P29_RS19165	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5P29_RS19170	COG0604	alcohol dehydrogenase
H5P29_RS19175	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS19180	COG0318	PFAM AMP-dependent synthetase and ligase
H5P29_RS19230	COG0657	acetylesterase activity
H5P29_RS19240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5P29_RS19245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5P29_RS19265	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS19270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H5P29_RS19275	COG0183	Belongs to the thiolase family
H5P29_RS19280	COG1960	acyl-CoA dehydrogenase activity
H5P29_RS19285	COG1960	acyl-CoA dehydrogenase activity
H5P29_RS19290	COG1024	Enoyl-CoA hydratase
H5P29_RS19295	COG0667	Aldo Keto reductase
H5P29_RS19300	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H5P29_RS19335	COG1079	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS19340	COG4603	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS19345	COG3845	ABC transporter
H5P29_RS19355	COG1183	phosphatidylcholine synthase activity
H5P29_RS19360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5P29_RS19365	COG0679	Auxin Efflux Carrier
H5P29_RS19380	COG4166	transmembrane transport
H5P29_RS19395	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H5P29_RS19400	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H5P29_RS19405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H5P29_RS19415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H5P29_RS19420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H5P29_RS19425	COG0785	Cytochrome C biogenesis protein
H5P29_RS19460	COG0861	Integral membrane protein TerC family
H5P29_RS19485	COG2308	Evidence 4 Homologs of previously reported genes of
H5P29_RS19500	COG0488	(ABC) transporter
H5P29_RS19515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H5P29_RS19520	COG0343	queuine tRNA-ribosyltransferase activity
H5P29_RS19525	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H5P29_RS19545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H5P29_RS19555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H5P29_RS19560	COG2095	MarC family integral membrane protein
H5P29_RS19575	COG0629	single-stranded DNA binding
H5P29_RS19585	COG2188	Transcriptional regulator
H5P29_RS19590	COG1940	carbohydrate kinase activity
H5P29_RS19590	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H5P29_RS19595	COG0395	ABC-type sugar transport system, permease component
H5P29_RS19625	COG1794	racemase activity, acting on amino acids and derivatives
H5P29_RS19630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H5P29_RS19635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5P29_RS19650	COG1309	transcriptional regulator
H5P29_RS19655	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS19660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H5P29_RS19660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H5P29_RS19665	COG0347	Belongs to the P(II) protein family
H5P29_RS19670	COG0174	glutamine synthetase
H5P29_RS19695	COG0174	glutamine synthetase
H5P29_RS19705	COG0697	spore germination
H5P29_RS19720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H5P29_RS19725	COG3956	TIGRFAM MazG family protein
H5P29_RS19730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H5P29_RS19735	COG1923	regulation of RNA biosynthetic process
H5P29_RS19740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H5P29_RS19745	COG0569	domain protein
H5P29_RS19750	COG2204	response regulator
H5P29_RS19755	COG5000	phosphorelay sensor kinase activity
H5P29_RS19760	COG2204	response regulator
H5P29_RS19765	COG3852	Histidine kinase
H5P29_RS19775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H5P29_RS19775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H5P29_RS19780	COG1058	Belongs to the CinA family
H5P29_RS19780	COG1546	Belongs to the CinA family
H5P29_RS19790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H5P29_RS19800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5P29_RS19805	COG0456	acetyltransferase
H5P29_RS19805	COG1214	PFAM Peptidase M22, glycoprotease
H5P29_RS19815	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5P29_RS19820	COG0022	dehydrogenase e1 component
H5P29_RS19820	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5P29_RS19825	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H5P29_RS19830	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H5P29_RS19835	COG0148	phosphopyruvate hydratase activity
H5P29_RS19855	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H5P29_RS19870	COG0504	CTP synthase activity
H5P29_RS19885	COG0149	triose-phosphate isomerase activity
H5P29_RS19895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H5P29_RS19900	COG0134	indole-3-glycerol-phosphate synthase activity
H5P29_RS19905	COG0315	cyclic pyranopterin monophosphate synthase activity
H5P29_RS19910	COG0303	'Molybdopterin
H5P29_RS19915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5P29_RS19925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5P29_RS19930	COG0372	Belongs to the citrate synthase family
H5P29_RS19935	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5P29_RS19945	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5P29_RS19950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5P29_RS19955	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5P29_RS19960	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5P29_RS19965	COG0750	zinc metalloprotease
H5P29_RS19975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H5P29_RS19980	COG0233	cytoplasmic translational termination
H5P29_RS19985	COG0528	UMP kinase activity
H5P29_RS19990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H5P29_RS19995	COG0052	Belongs to the universal ribosomal protein uS2 family
H5P29_RS20030	COG0537	adenosine 5'-monophosphoramidase activity
H5P29_RS20055	COG3706	GGDEF domain
H5P29_RS20065	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H5P29_RS20075	COG1686	Belongs to the peptidase S11 family
H5P29_RS20080	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H5P29_RS20095	COG1760	l-serine dehydratase
H5P29_RS20105	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H5P29_RS20110	COG0154	amidase activity
H5P29_RS20115	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H5P29_RS20125	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H5P29_RS20130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H5P29_RS20140	COG1960	acyl-CoA dehydrogenase activity
H5P29_RS20145	COG0540	Belongs to the ATCase OTCase family
H5P29_RS20150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H5P29_RS20155	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H5P29_RS20160	COG0758	DNA mediated transformation
H5P29_RS20165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5P29_RS20170	COG0557	exoribonuclease II activity
H5P29_RS20190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H5P29_RS20200	COG0784	Response regulator, receiver
H5P29_RS20215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H5P29_RS20220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H5P29_RS20225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H5P29_RS20235	COG0492	ferredoxin-NADP+ reductase activity
H5P29_RS20240	COG0633	Ferredoxin
H5P29_RS20255	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H5P29_RS20255	COG3218	ABC-type transport auxiliary lipoprotein component
H5P29_RS20265	COG1127	ABC transporter
H5P29_RS20275	COG4948	Mandelate Racemase Muconate Lactonizing
H5P29_RS20290	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS20295	COG0281	malic enzyme
H5P29_RS20295	COG0280	phosphate acetyltransferase
H5P29_RS20305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5P29_RS20310	COG5265	(ABC) transporter
H5P29_RS20315	COG0640	Transcriptional regulator
H5P29_RS20325	COG0740	serine-type endopeptidase activity
H5P29_RS20365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H5P29_RS20370	COG3384	dioxygenase
H5P29_RS20380	COG0519	Catalyzes the synthesis of GMP from XMP
H5P29_RS20400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H5P29_RS20405	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H5P29_RS20410	COG0047	phosphoribosylformylglycinamidine synthase activity
H5P29_RS20425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5P29_RS20430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H5P29_RS20440	COG2226	methyltransferase
H5P29_RS20450	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H5P29_RS20455	COG2814	Major facilitator Superfamily
H5P29_RS20460	COG0037	tRNA processing
H5P29_RS20470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H5P29_RS20480	COG1733	regulation of RNA biosynthetic process
H5P29_RS20485	COG0702	epimerase
H5P29_RS20495	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H5P29_RS20510	COG0538	isocitrate dehydrogenase activity
H5P29_RS20525	COG0346	lactoylglutathione lyase activity
H5P29_RS20530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H5P29_RS20535	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H5P29_RS20545	COG2313	pseudouridylate synthase activity
H5P29_RS20560	COG0316	Belongs to the HesB IscA family
H5P29_RS20565	COG2151	metal-sulfur cluster biosynthetic enzyme
H5P29_RS20570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H5P29_RS20575	COG0719	Fe-S assembly protein
H5P29_RS20580	COG0396	ATPase activity
H5P29_RS20590	COG0719	Fe-S assembly protein
H5P29_RS20600	COG2945	thiolester hydrolase activity
H5P29_RS20630	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H5P29_RS20640	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H5P29_RS20645	COG0739	heme binding
H5P29_RS20680	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
H5P29_RS20690	COG0411	ABC transporter
H5P29_RS20700	COG0559	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS20720	COG1917	Cupin 2, conserved barrel domain protein
H5P29_RS20725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5P29_RS20735	COG0583	DNA-binding transcription factor activity
H5P29_RS20755	COG0583	DNA-binding transcription factor activity
H5P29_RS20775	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H5P29_RS20785	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H5P29_RS20790	COG0156	8-amino-7-oxononanoate synthase activity
H5P29_RS20800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H5P29_RS20805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5P29_RS20820	COG4608	Belongs to the ABC transporter superfamily
H5P29_RS20825	COG0444	Belongs to the ABC transporter superfamily
H5P29_RS20830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS20835	COG0601	transmembrane transport
H5P29_RS20840	COG1396	sequence-specific DNA binding
H5P29_RS20845	COG0747	negative chemotaxis
H5P29_RS20860	COG0776	regulation of translation
H5P29_RS20870	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H5P29_RS20875	COG0740	serine-type endopeptidase activity
H5P29_RS20920	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H5P29_RS20925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H5P29_RS20935	COG0584	glycerophosphoryl diester phosphodiesterase
H5P29_RS20940	COG0010	Belongs to the arginase family
H5P29_RS20955	COG1612	heme a metabolic process
H5P29_RS20985	COG0297	glycogen (starch) synthase activity
H5P29_RS21020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5P29_RS21035	COG0776	regulation of translation
H5P29_RS21040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5P29_RS21045	COG0416	fatty acid biosynthetic process
H5P29_RS21060	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5P29_RS21065	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H5P29_RS21080	COG1174	glycine betaine transport
H5P29_RS21085	COG1125	glycine betaine transport
H5P29_RS21090	COG1174	glycine betaine transport
H5P29_RS21095	COG1732	Glycine betaine
H5P29_RS21100	COG2814	Major facilitator Superfamily
H5P29_RS21105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H5P29_RS21110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H5P29_RS21120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5P29_RS21120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5P29_RS21125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H5P29_RS21130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H5P29_RS21140	COG2989	Protein conserved in bacteria
H5P29_RS21155	COG1024	Enoyl-CoA hydratase
H5P29_RS21160	COG0113	porphobilinogen synthase activity
H5P29_RS21170	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H5P29_RS21180	COG0628	permease
H5P29_RS21185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H5P29_RS21195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H5P29_RS21210	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H5P29_RS21230	COG0477	Major facilitator Superfamily
H5P29_RS21235	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H5P29_RS21275	COG1079	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS21280	COG4603	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS21285	COG3845	ABC transporter
H5P29_RS21325	COG1079	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS21330	COG4603	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS21335	COG3845	ABC transporter
H5P29_RS21345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H5P29_RS21355	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H5P29_RS21380	COG0730	response to heat
H5P29_RS21390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5P29_RS21400	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS21405	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H5P29_RS21410	COG1349	DNA-binding transcription factor activity
H5P29_RS21425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H5P29_RS21430	COG0583	DNA-binding transcription factor activity
H5P29_RS21440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5P29_RS21445	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H5P29_RS21450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5P29_RS21455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H5P29_RS21460	COG2188	Transcriptional regulator
H5P29_RS21485	COG0583	DNA-binding transcription factor activity
H5P29_RS21490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5P29_RS21515	COG1653	transport
H5P29_RS21540	COG3842	ATPase activity
H5P29_RS21545	COG2252	PERMEase
H5P29_RS21560	COG3842	ATPase activity
H5P29_RS21570	COG0395	ABC-type sugar transport system, permease component
H5P29_RS21585	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H5P29_RS21600	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5P29_RS21605	COG1132	(ABC) transporter
H5P29_RS21610	COG3459	Glycosyltransferase 36 associated
H5P29_RS21625	COG3314	Sporulation integral membrane protein YlbJ
H5P29_RS21630	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H5P29_RS21640	COG2986	histidine ammonia-lyase
H5P29_RS21645	COG1228	amidohydrolase
H5P29_RS21665	COG0251	oxidation-reduction process
H5P29_RS21675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5P29_RS21680	COG0803	Belongs to the bacterial solute-binding protein 9 family
H5P29_RS21690	COG0523	cobalamin synthesis protein
H5P29_RS21710	COG1234	tRNA 3'-trailer cleavage
H5P29_RS21720	COG1063	alcohol dehydrogenase
H5P29_RS21735	COG4948	Mandelate Racemase Muconate Lactonizing
H5P29_RS21745	COG1960	acyl-CoA dehydrogenase activity
H5P29_RS21755	COG1902	pentaerythritol trinitrate reductase activity
H5P29_RS21755	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5P29_RS21760	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H5P29_RS21775	COG5598	trimethylamine methyltransferase
H5P29_RS21780	COG0583	DNA-binding transcription factor activity
H5P29_RS21785	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H5P29_RS21805	COG1663	tetraacyldisaccharide 4'-kinase activity
H5P29_RS21810	COG1519	Transferase
H5P29_RS21825	COG0483	inositol monophosphate 1-phosphatase activity
H5P29_RS21830	COG0312	modulator of DNA gyrase
H5P29_RS21845	COG0612	Peptidase, M16
H5P29_RS21850	COG0612	Peptidase, M16
H5P29_RS21855	COG0742	ribosomal rna small subunit methyltransferase
H5P29_RS21860	COG1187	pseudouridine synthase activity
H5P29_RS21865	COG0590	tRNA wobble adenosine to inosine editing
H5P29_RS21875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H5P29_RS21890	COG0196	riboflavin kinase activity
H5P29_RS21905	COG2814	Major facilitator Superfamily
H5P29_RS21915	COG1846	Transcriptional regulator
H5P29_RS21920	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5P29_RS21920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5P29_RS21930	COG0459	protein refolding
H5P29_RS21960	COG3237	CsbD-like
H5P29_RS21975	COG0114	fumarate hydratase activity
H5P29_RS21980	COG2259	Doxx family
H5P29_RS21990	COG0248	Ppx GppA phosphatase
H5P29_RS21995	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H5P29_RS22015	COG1126	abc transporter atp-binding protein
H5P29_RS22020	COG0765	amino acid transport
H5P29_RS22025	COG4597	amino acid ABC transporter
H5P29_RS22030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5P29_RS22040	COG0626	cystathionine gamma-synthase activity
H5P29_RS22065	COG3852	Histidine kinase
H5P29_RS22110	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H5P29_RS22120	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H5P29_RS22225	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H5P29_RS22235	COG5425	PFAM Usg family protein
H5P29_RS22245	COG0071	Belongs to the small heat shock protein (HSP20) family
H5P29_RS22250	COG0071	Belongs to the small heat shock protein (HSP20) family
H5P29_RS22260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H5P29_RS22270	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H5P29_RS22315	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS22320	COG1129	ABC transporter
H5P29_RS22325	COG0702	epimerase
H5P29_RS22335	COG2186	Transcriptional regulator
H5P29_RS22350	COG2186	Transcriptional regulator
H5P29_RS22360	COG1136	(ABC) transporter
H5P29_RS22475	COG0517	IMP dehydrogenase activity
H5P29_RS22480	COG4974	Belongs to the 'phage' integrase family
H5P29_RS22490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5P29_RS22505	COG3265	gluconokinase activity
H5P29_RS22510	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H5P29_RS22520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H5P29_RS22525	COG2084	Dehydrogenase
H5P29_RS22560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H5P29_RS22575	COG1431	PFAM Stem cell self-renewal protein Piwi
H5P29_RS22580	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
H5P29_RS22620	COG0444	Belongs to the ABC transporter superfamily
H5P29_RS22625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5P29_RS22640	COG0747	negative chemotaxis
H5P29_RS22645	COG2186	Transcriptional regulator
H5P29_RS22670	COG3474	cytochrome
H5P29_RS22820	COG0210	DNA helicase
H5P29_RS22865	COG0798	PFAM Bile acid sodium symporter
H5P29_RS22875	COG0431	NADPH-dependent FMN reductase
H5P29_RS22900	COG0753	catalase activity
H5P29_RS22940	COG1278	Cold shock
H5P29_RS22955	COG3685	Protein conserved in bacteria
H5P29_RS22965	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS23085	COG2827	Endonuclease containing a URI domain
H5P29_RS23090	COG0784	Response regulator, receiver
H5P29_RS23090	COG2205	protein histidine kinase activity
H5P29_RS23090	COG2198	Histidine kinase
H5P29_RS23095	COG2197	response regulator
H5P29_RS23100	COG1280	lysine exporter protein (LysE YggA)
H5P29_RS23115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS23125	COG0747	negative chemotaxis
H5P29_RS23155	COG0628	permease
H5P29_RS23160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H5P29_RS23165	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H5P29_RS23170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H5P29_RS23210	COG0583	DNA-binding transcription factor activity
H5P29_RS23220	COG1024	Enoyl-CoA hydratase
H5P29_RS23225	COG1960	acyl-CoA dehydrogenase activity
H5P29_RS23230	COG0318	PFAM AMP-dependent synthetase and ligase
H5P29_RS23235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H5P29_RS23260	COG0583	DNA-binding transcription factor activity
H5P29_RS23265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5P29_RS23270	COG0765	amino acid transport
H5P29_RS23280	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H5P29_RS23295	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5P29_RS23325	COG0243	molybdopterin cofactor binding
H5P29_RS23330	COG0488	(ABC) transporter
H5P29_RS23335	COG2211	Major facilitator Superfamily
H5P29_RS23355	COG0105	UTP biosynthetic process
H5P29_RS23370	COG0314	molybdopterin synthase activity
H5P29_RS23385	COG0322	excinuclease ABC activity
H5P29_RS23435	COG0625	glutathione transferase activity
H5P29_RS23450	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H5P29_RS23475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H5P29_RS23500	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H5P29_RS23505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H5P29_RS23510	COG0194	GDP metabolic process
H5P29_RS23515	COG1561	YicC-like family, N-terminal region
H5P29_RS23520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H5P29_RS23525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5P29_RS23530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5P29_RS23540	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H5P29_RS23545	COG1368	sulfuric ester hydrolase activity
H5P29_RS23550	COG0360	Binds together with S18 to 16S ribosomal RNA
H5P29_RS23560	COG0359	binds to the 23S rRNA
H5P29_RS23565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H5P29_RS23570	COG1742	UPF0060 membrane protein
H5P29_RS23575	COG3468	outer membrane autotransporter barrel domain protein
H5P29_RS23580	COG0305	Participates in initiation and elongation during chromosome replication
H5P29_RS23595	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H5P29_RS23605	COG4221	oxidoreductase activity
H5P29_RS23610	COG0471	metal ion transport
H5P29_RS23610	COG3273	potassium ion transport
H5P29_RS23635	COG0318	PFAM AMP-dependent synthetase and ligase
H5P29_RS23635	COG0204	Acyl-transferase
H5P29_RS23645	COG0688	phosphatidylethanolamine metabolic process
H5P29_RS23650	COG5265	(ABC) transporter
H5P29_RS23660	COG1652	LysM domain
H5P29_RS23675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H5P29_RS23705	COG2852	Protein conserved in bacteria
H5P29_RS23710	COG0215	cysteine-tRNA ligase activity
H5P29_RS23750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H5P29_RS23760	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H5P29_RS23785	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS23795	COG0640	Transcriptional regulator
H5P29_RS23830	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
H5P29_RS23860	COG1381	Involved in DNA repair and RecF pathway recombination
H5P29_RS23865	COG0477	Major facilitator Superfamily
H5P29_RS23885	COG2814	Major facilitator Superfamily
H5P29_RS23910	COG0402	S-adenosylhomocysteine deaminase activity
H5P29_RS23940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5P29_RS23955	COG1280	lysine exporter protein (LysE YggA)
H5P29_RS23975	COG2814	Major facilitator Superfamily
H5P29_RS24000	COG0300	oxidoreductase activity
H5P29_RS24015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H5P29_RS24020	COG0571	ribonuclease III activity
H5P29_RS24025	COG0681	Belongs to the peptidase S26 family
H5P29_RS24030	COG0736	holo-[acyl-carrier-protein] synthase activity
H5P29_RS24035	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H5P29_RS24045	COG1758	RNA polymerase activity
H5P29_RS24065	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H5P29_RS24070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5P29_RS24075	COG0741	lytic transglycosylase activity
H5P29_RS24100	COG4974	Belongs to the 'phage' integrase family
H5P29_RS24115	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
H5P29_RS24120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5P29_RS24130	COG1960	acyl-CoA dehydrogenase activity
H5P29_RS24150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H5P29_RS24155	COG4770	biotin carboxylase activity
H5P29_RS24165	COG0450	alkyl hydroperoxide reductase
H5P29_RS24185	COG0625	glutathione transferase activity
H5P29_RS24195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H5P29_RS24235	COG0438	transferase activity, transferring glycosyl groups
H5P29_RS24250	COG0308	aminopeptidase N
H5P29_RS24255	COG2202	Pas domain
H5P29_RS24255	COG2205	protein histidine kinase activity
H5P29_RS24265	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H5P29_RS24270	COG2205	protein histidine kinase activity
H5P29_RS24275	COG0745	RESPONSE REGULATOR receiver
H5P29_RS24280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5P29_RS24285	COG3088	subunit of a heme lyase
H5P29_RS24290	COG1138	Cytochrome C-type biogenesis protein
H5P29_RS24295	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H5P29_RS24300	COG4235	cytochrome complex assembly
H5P29_RS24330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H5P29_RS24365	COG2205	protein histidine kinase activity
H5P29_RS24375	COG2166	iron-sulfur cluster assembly
H5P29_RS24380	COG4957	zinc ion binding
H5P29_RS24385	COG1320	monovalent cation:proton antiporter activity
H5P29_RS24390	COG2212	antiporter activity
H5P29_RS24395	COG1863	multisubunit Na H antiporter MnhE subunit
H5P29_RS24400	COG0651	ATP synthesis coupled electron transport
H5P29_RS24405	COG1006	Multisubunit Na H antiporter MnhC subunit
H5P29_RS24410	COG2111	Na H antiporter
H5P29_RS24415	COG2111	Na H antiporter
H5P29_RS24415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H5P29_RS24430	COG2010	Cytochrome c
H5P29_RS24440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H5P29_RS24445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H5P29_RS24455	COG1376	ErfK ybiS ycfS ynhG family protein
H5P29_RS24460	COG0433	COG0433 Predicted ATPase
H5P29_RS24465	COG2336	PFAM SpoVT AbrB
H5P29_RS24470	COG3654	unkown
H5P29_RS24475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5P29_RS24485	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS24490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5P29_RS24495	COG1309	transcriptional regulator
H5P29_RS24500	COG3119	arylsulfatase activity
H5P29_RS24510	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H5P29_RS24515	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS24525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5P29_RS24550	COG4172	Belongs to the ABC transporter superfamily
H5P29_RS24555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS24560	COG0601	transmembrane transport
H5P29_RS24570	COG0366	Alpha amylase catalytic
H5P29_RS24575	COG1523	belongs to the glycosyl hydrolase 13 family
H5P29_RS24580	COG0033	Phosphoglucomutase
H5P29_RS24585	COG0297	glycogen (starch) synthase activity
H5P29_RS24590	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H5P29_RS24595	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H5P29_RS24600	COG0058	SHG alpha-glucan phosphorylase activity
H5P29_RS24620	COG1940	carbohydrate kinase activity
H5P29_RS24640	COG1218	3'(2'),5'-bisphosphate nucleotidase
H5P29_RS24650	COG0175	sulfate reduction
H5P29_RS24690	COG3685	Protein conserved in bacteria
H5P29_RS24720	COG0318	PFAM AMP-dependent synthetase and ligase
H5P29_RS24735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H5P29_RS24735	COG0574	Belongs to the PEP-utilizing enzyme family
H5P29_RS24750	COG0583	DNA-binding transcription factor activity
H5P29_RS24755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5P29_RS24760	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H5P29_RS24770	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H5P29_RS24770	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H5P29_RS24780	COG0318	PFAM AMP-dependent synthetase and ligase
H5P29_RS24795	COG0183	Belongs to the thiolase family
H5P29_RS24805	COG0454	-acetyltransferase
H5P29_RS24810	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H5P29_RS24820	COG4172	Belongs to the ABC transporter superfamily
H5P29_RS24825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS24835	COG0747	negative chemotaxis
H5P29_RS24840	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H5P29_RS24845	COG2971	BadF BadG BcrA BcrD
H5P29_RS24850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H5P29_RS24855	COG1737	Transcriptional regulator
H5P29_RS24860	COG0243	molybdopterin cofactor binding
H5P29_RS24870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5P29_RS24880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5P29_RS24885	COG3707	response regulator
H5P29_RS24890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5P29_RS24895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5P29_RS24910	COG1196	nuclear chromosome segregation
H5P29_RS24925	COG1194	a g-specific adenine glycosylase
H5P29_RS24930	COG1011	Hydrolase
H5P29_RS24935	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H5P29_RS24940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5P29_RS24960	COG0583	DNA-binding transcription factor activity
H5P29_RS24965	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H5P29_RS24980	COG0612	Peptidase, M16
H5P29_RS24985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5P29_RS24995	COG1678	Uncharacterized ACR, COG1678
H5P29_RS25005	COG0678	peroxiredoxin activity
H5P29_RS25010	COG0328	RNA-DNA hybrid ribonuclease activity
H5P29_RS25015	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H5P29_RS25020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H5P29_RS25025	COG3346	SURF1 family
H5P29_RS25045	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H5P29_RS25055	COG0109	protoheme IX farnesyltransferase activity
H5P29_RS25060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H5P29_RS25065	COG1565	acr, cog1565
H5P29_RS25065	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H5P29_RS25075	COG0312	modulator of DNA gyrase
H5P29_RS25080	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H5P29_RS25090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5P29_RS25100	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H5P29_RS25105	COG1741	Belongs to the pirin family
H5P29_RS25120	COG1733	regulation of RNA biosynthetic process
H5P29_RS25125	COG1722	exodeoxyribonuclease VII activity
H5P29_RS25130	COG0123	including yeast histone deacetylase and acetoin utilization protein
H5P29_RS25135	COG1309	transcriptional regulator
H5P29_RS25155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5P29_RS25155	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5P29_RS25160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H5P29_RS25170	COG0406	alpha-ribazole phosphatase activity
H5P29_RS25175	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H5P29_RS25180	COG0484	heat shock protein binding
H5P29_RS25190	COG0259	pyridoxamine-phosphate oxidase activity
H5P29_RS25195	COG1024	Enoyl-CoA hydratase
H5P29_RS25200	COG1960	acyl-CoA dehydrogenase activity
H5P29_RS25215	COG0151	Belongs to the GarS family
H5P29_RS25235	COG0009	L-threonylcarbamoyladenylate synthase
H5P29_RS25250	COG0751	glycine-tRNA ligase activity
H5P29_RS25260	COG0752	glycyl-tRNA synthetase alpha subunit
H5P29_RS25270	COG0142	geranyltranstransferase activity
H5P29_RS25295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H5P29_RS25300	COG0521	Mo-molybdopterin cofactor biosynthetic process
H5P29_RS25315	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H5P29_RS25325	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H5P29_RS25330	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H5P29_RS25335	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H5P29_RS25340	COG0356	it plays a direct role in the translocation of protons across the membrane
H5P29_RS25355	COG1160	GTP binding
H5P29_RS25370	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H5P29_RS25375	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H5P29_RS25385	COG0583	DNA-binding transcription factor activity
H5P29_RS25390	COG1393	Belongs to the ArsC family
H5P29_RS25395	COG0251	oxidation-reduction process
H5P29_RS25405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5P29_RS25425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5P29_RS25435	COG0402	S-adenosylhomocysteine deaminase activity
H5P29_RS25445	COG0494	nUDIX hydrolase
H5P29_RS25450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5P29_RS25475	COG0583	DNA-binding transcription factor activity
H5P29_RS25480	COG0242	peptide deformylase activity
H5P29_RS25495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H5P29_RS25500	COG4172	Belongs to the ABC transporter superfamily
H5P29_RS25505	COG0444	Belongs to the ABC transporter superfamily
H5P29_RS25510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS25515	COG0601	transmembrane transport
H5P29_RS25560	COG0840	transmembrane signaling receptor activity
H5P29_RS25565	COG4957	zinc ion binding
H5P29_RS25590	COG1959	2 iron, 2 sulfur cluster binding
H5P29_RS25600	COG0747	negative chemotaxis
H5P29_RS25610	COG0583	DNA-binding transcription factor activity
H5P29_RS25620	COG4974	Belongs to the 'phage' integrase family
H5P29_RS25625	COG0517	IMP dehydrogenase activity
H5P29_RS25640	COG3938	Belongs to the proline racemase family
H5P29_RS25660	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H5P29_RS25665	COG1959	2 iron, 2 sulfur cluster binding
H5P29_RS25670	COG2346	COG2346, Truncated hemoglobins
H5P29_RS25690	COG3278	Belongs to the heme-copper respiratory oxidase family
H5P29_RS25705	COG2010	Cytochrome c
H5P29_RS25745	COG0583	DNA-binding transcription factor activity
H5P29_RS25755	COG0640	Transcriptional regulator
H5P29_RS25770	COG1234	tRNA 3'-trailer cleavage
H5P29_RS25820	COG1525	nuclease
H5P29_RS25835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5P29_RS25850	COG2832	Protein of unknown function (DUF454)
H5P29_RS25860	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H5P29_RS25870	COG0826	peptidase U32
H5P29_RS25880	COG0521	Mo-molybdopterin cofactor biosynthetic process
H5P29_RS25885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H5P29_RS25890	COG2186	Transcriptional regulator
H5P29_RS25915	COG2151	metal-sulfur cluster biosynthetic enzyme
H5P29_RS25980	COG3794	PFAM blue (type 1) copper domain protein
H5P29_RS26015	COG3005	denitrification pathway
H5P29_RS26040	COG4459	periplasmic nitrate reductase
H5P29_RS26045	COG1959	2 iron, 2 sulfur cluster binding
H5P29_RS26070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5P29_RS26085	COG0714	Associated with various cellular activities
H5P29_RS26090	COG3256	nitric oxide reductase
H5P29_RS26105	COG1845	cytochrome c oxidase, subunit III
H5P29_RS26130	COG4521	taurine ABC transporter
H5P29_RS26160	COG5489	Protein of unknown function (DUF736)
H5P29_RS26170	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H5P29_RS26175	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS26180	COG1129	ABC transporter
H5P29_RS26200	COG3257	ureidoglycine aminohydrolase activity
H5P29_RS26205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H5P29_RS26240	COG1079	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS26245	COG4603	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS26250	COG3845	ABC transporter
H5P29_RS26280	COG2351	hydroxyisourate hydrolase activity
H5P29_RS26285	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H5P29_RS26295	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
H5P29_RS26315	COG1335	isochorismatase
H5P29_RS26325	COG2188	Transcriptional regulator
H5P29_RS26330	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H5P29_RS26335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5P29_RS26340	COG1760	l-serine dehydratase
H5P29_RS26345	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H5P29_RS26355	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5P29_RS26355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H5P29_RS26400	COG4974	Belongs to the 'phage' integrase family
H5P29_RS26420	COG4227	nucleotidyltransferase activity
H5P29_RS26445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5P29_RS26450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5P29_RS26460	COG1475	DNA binding
H5P29_RS26480	COG5489	Protein of unknown function (DUF736)
H5P29_RS26490	COG3916	Acyl-homoserine-lactone synthase
H5P29_RS26495	COG2197	response regulator
H5P29_RS26505	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H5P29_RS26510	COG1476	TRANSCRIPTIONal
H5P29_RS26570	COG4957	zinc ion binding
H5P29_RS26585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5P29_RS26590	COG0765	amino acid transport
H5P29_RS26595	COG0765	amino acid transport
H5P29_RS26600	COG1126	abc transporter atp-binding protein
H5P29_RS26605	COG3608	succinylglutamate desuccinylase aspartoacylase
H5P29_RS26640	COG0741	lytic transglycosylase activity
H5P29_RS26660	COG1522	sequence-specific DNA binding
H5P29_RS26670	COG4962	Type ii secretion system protein e
H5P29_RS26675	COG3838	Conjugal transfer protein Trbc
H5P29_RS26685	COG3451	type IV secretory pathway VirB4
H5P29_RS26715	COG2948	multi-organism process
H5P29_RS26730	COG3550	peptidyl-serine autophosphorylation
H5P29_RS26735	COG1396	sequence-specific DNA binding
H5P29_RS26770	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H5P29_RS26775	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H5P29_RS26775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H5P29_RS26780	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H5P29_RS26785	COG0583	DNA-binding transcription factor activity
H5P29_RS26790	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H5P29_RS26795	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H5P29_RS26800	COG0124	histidyl-tRNA synthetase
H5P29_RS26815	COG2818	Glycosylase
H5P29_RS26820	COG1376	ErfK ybiS ycfS ynhG family protein
H5P29_RS26825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H5P29_RS26830	COG1376	ErfK ybiS ycfS ynhG family protein
H5P29_RS26830	COG1388	LysM domain
H5P29_RS26840	COG0247	lactate metabolic process
H5P29_RS26855	COG2852	Protein conserved in bacteria
H5P29_RS26865	COG0277	FAD linked oxidase domain protein
H5P29_RS26875	COG2186	Transcriptional regulator
H5P29_RS26880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H5P29_RS26945	COG0583	DNA-binding transcription factor activity
H5P29_RS26950	COG1570	exodeoxyribonuclease VII activity
H5P29_RS26960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5P29_RS26965	COG1178	ABC-type Fe3 transport system permease component
H5P29_RS26970	COG1840	ABC-type Fe3 transport system, periplasmic component
H5P29_RS26975	COG2205	protein histidine kinase activity
H5P29_RS26980	COG5490	Phasin protein
H5P29_RS27005	COG1177	transmembrane transport
H5P29_RS27010	COG1176	ABC-type spermidine putrescine transport system, permease component I
H5P29_RS27015	COG3842	ATPase activity
H5P29_RS27030	COG0431	NADPH-dependent FMN reductase
H5P29_RS27035	COG2814	Major facilitator Superfamily
H5P29_RS27045	COG5001	Diguanylate cyclase
H5P29_RS27045	COG3300	MHYT domain
H5P29_RS27055	COG2224	Isocitrate lyase
H5P29_RS27075	COG0174	glutamine synthetase
H5P29_RS27080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5P29_RS27090	COG0745	RESPONSE REGULATOR receiver
H5P29_RS27105	COG3794	PFAM blue (type 1) copper domain protein
H5P29_RS27110	COG1595	DNA-templated transcription, initiation
H5P29_RS27130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H5P29_RS27135	COG0363	glucosamine-6-phosphate deaminase activity
H5P29_RS27140	COG0129	dihydroxy-acid dehydratase activity
H5P29_RS27150	COG0488	(ABC) transporter
H5P29_RS27165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H5P29_RS27230	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H5P29_RS27235	COG4149	molybdate abc transporter
H5P29_RS27240	COG0725	ABC transporter, periplasmic molybdate-binding protein
H5P29_RS27245	COG0730	response to heat
H5P29_RS27250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H5P29_RS27255	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H5P29_RS27265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5P29_RS27340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H5P29_RS27350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H5P29_RS27355	COG5328	Belongs to the UPF0262 family
H5P29_RS27365	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H5P29_RS27370	COG0424	maF-like protein
H5P29_RS27375	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H5P29_RS27390	COG0577	efflux transmembrane transporter activity
H5P29_RS27390	COG1136	(ABC) transporter
H5P29_RS27395	COG1136	(ABC) transporter
H5P29_RS27415	COG3300	MHYT domain
H5P29_RS27415	COG5001	Diguanylate cyclase
H5P29_RS27425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H5P29_RS27430	COG2186	Transcriptional regulator
H5P29_RS27460	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H5P29_RS27465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H5P29_RS27495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5P29_RS27505	COG0251	oxidation-reduction process
H5P29_RS27515	COG0765	amino acid transport
H5P29_RS27520	COG0765	amino acid transport
H5P29_RS27540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5P29_RS27545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5P29_RS27550	COG1120	ATPase activity
H5P29_RS27555	COG3585	molybdate ion transport
H5P29_RS27570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5P29_RS27575	COG4215	(ABC) transporter
H5P29_RS27580	COG0765	amino acid transport
H5P29_RS27585	COG3457	Alanine racemase
H5P29_RS27590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5P29_RS27600	COG0156	8-amino-7-oxononanoate synthase activity
H5P29_RS27605	COG0436	Aminotransferase
H5P29_RS27610	COG1970	mechanosensitive ion channel activity
H5P29_RS27615	COG2205	protein histidine kinase activity
H5P29_RS27615	COG0784	Response regulator, receiver
H5P29_RS27615	COG2198	Histidine kinase
H5P29_RS27635	COG0167	dihydroorotate dehydrogenase activity
H5P29_RS27645	COG0123	including yeast histone deacetylase and acetoin utilization protein
H5P29_RS27655	COG5001	Diguanylate cyclase
H5P29_RS27665	COG0463	Glycosyl transferase, family 2
H5P29_RS27680	COG0717	Belongs to the dCTP deaminase family
H5P29_RS27690	COG2967	ApaG domain
H5P29_RS27700	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H5P29_RS27705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H5P29_RS27715	COG0598	Magnesium transport protein CorA
H5P29_RS27720	COG0704	Plays a role in the regulation of phosphate uptake
H5P29_RS27730	COG0640	Transcriptional regulator
H5P29_RS27735	COG5002	protein histidine kinase activity
H5P29_RS27740	COG2326	polyphosphate kinase activity
H5P29_RS27745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5P29_RS27755	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
H5P29_RS27785	COG1024	Enoyl-CoA hydratase
H5P29_RS27785	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5P29_RS27790	COG0183	Belongs to the thiolase family
H5P29_RS27795	COG1960	acyl-CoA dehydrogenase activity
H5P29_RS27800	COG1960	acyl-CoA dehydrogenase activity
H5P29_RS27810	COG0730	response to heat
H5P29_RS27820	COG0789	Transcriptional regulator
H5P29_RS27830	COG1201	RNA secondary structure unwinding
H5P29_RS27850	COG1793	dna ligase
H5P29_RS27910	COG3422	double-strand break repair
H5P29_RS27925	COG0444	Belongs to the ABC transporter superfamily
H5P29_RS27930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS27940	COG0747	negative chemotaxis
H5P29_RS27945	COG4608	Belongs to the ABC transporter superfamily
H5P29_RS27950	COG0444	Belongs to the ABC transporter superfamily
H5P29_RS27955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS27960	COG0601	transmembrane transport
H5P29_RS27965	COG0747	negative chemotaxis
H5P29_RS27980	COG0546	phosphoglycolate phosphatase activity
H5P29_RS27985	COG0024	Methionine aminopeptidase
H5P29_RS28005	COG2226	methyltransferase
H5P29_RS28010	COG0129	dihydroxy-acid dehydratase activity
H5P29_RS28080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5P29_RS28085	COG0166	Belongs to the GPI family
H5P29_RS28100	COG0489	protein tyrosine kinase activity
H5P29_RS28125	COG0583	DNA-binding transcription factor activity
H5P29_RS28140	COG3383	formate dehydrogenase (NAD+) activity
H5P29_RS28145	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H5P29_RS28155	COG2197	response regulator
H5P29_RS28190	COG5002	protein histidine kinase activity
H5P29_RS28195	COG1349	DNA-binding transcription factor activity
H5P29_RS28205	COG4175	Glycine betaine
H5P29_RS28205	COG0517	IMP dehydrogenase activity
H5P29_RS28210	COG4176	ABC-type proline glycine betaine transport system permease component
H5P29_RS28225	COG2340	Cysteine-rich secretory protein family
H5P29_RS28230	COG0697	spore germination
H5P29_RS28240	COG0402	S-adenosylhomocysteine deaminase activity
H5P29_RS28245	COG1079	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS28250	COG4603	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS28255	COG3845	ABC transporter
H5P29_RS28265	COG1132	(ABC) transporter
H5P29_RS28270	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS28275	COG0288	reversible hydration of carbon dioxide
H5P29_RS28315	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H5P29_RS28320	COG0594	ribonuclease P activity
H5P29_RS28325	COG0706	membrane insertase activity
H5P29_RS28335	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H5P29_RS28345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5P29_RS28350	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H5P29_RS28365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H5P29_RS28380	COG3186	Phenylalanine-4-hydroxylase
H5P29_RS28390	COG0477	Major facilitator Superfamily
H5P29_RS28395	COG3706	GGDEF domain
H5P29_RS28415	COG2171	N-acyltransferase activity
H5P29_RS28425	COG3152	Membrane
H5P29_RS28445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5P29_RS28465	COG0101	tRNA pseudouridine synthase activity
H5P29_RS28475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H5P29_RS28480	COG0242	peptide deformylase activity
H5P29_RS28515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5P29_RS28525	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H5P29_RS28530	COG3773	Cell wall hydrolase
H5P29_RS28530	COG3409	Peptidoglycan-binding domain 1 protein
H5P29_RS28540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H5P29_RS28545	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H5P29_RS28565	COG2816	NAD+ diphosphatase activity
H5P29_RS28570	COG2226	methyltransferase
H5P29_RS28575	COG0077	Prephenate dehydratase
H5P29_RS28575	COG1605	Chorismate mutase
H5P29_RS28580	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H5P29_RS28585	COG3474	cytochrome
H5P29_RS28590	COG4166	transmembrane transport
H5P29_RS28595	COG4166	transmembrane transport
H5P29_RS28600	COG4174	ABC transporter (Permease)
H5P29_RS28605	COG4239	(ABC) transporter, permease
H5P29_RS28610	COG4172	Belongs to the ABC transporter superfamily
H5P29_RS28620	COG0791	NLP P60 protein
H5P29_RS28630	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H5P29_RS28665	COG4964	Belongs to the GSP D family
H5P29_RS28700	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H5P29_RS28705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H5P29_RS28710	COG1024	Enoyl-CoA hydratase
H5P29_RS28715	COG0268	Binds directly to 16S ribosomal RNA
H5P29_RS28725	COG1448	Aminotransferase
H5P29_RS28730	COG0028	Belongs to the TPP enzyme family
H5P29_RS28765	COG1022	Amp-dependent synthetase and ligase
H5P29_RS28815	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H5P29_RS28820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5P29_RS28830	COG0523	cobalamin synthesis protein
H5P29_RS28845	COG0402	S-adenosylhomocysteine deaminase activity
H5P29_RS28855	COG1942	4-Oxalocrotonate Tautomerase
H5P29_RS28870	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H5P29_RS28885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H5P29_RS28895	COG0402	S-adenosylhomocysteine deaminase activity
H5P29_RS28905	COG4948	Mandelate Racemase Muconate Lactonizing
H5P29_RS28915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5P29_RS28920	COG4521	taurine ABC transporter
H5P29_RS28925	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H5P29_RS28930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5P29_RS28945	COG0028	Belongs to the TPP enzyme family
H5P29_RS28950	COG2855	membrane
H5P29_RS28970	COG0829	nickel cation binding
H5P29_RS28975	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H5P29_RS28980	COG0804	urea catabolic process
H5P29_RS28985	COG0832	Belongs to the urease beta subunit family
H5P29_RS28985	COG0831	urea catabolic process
H5P29_RS28990	COG0830	nickel cation binding
H5P29_RS29000	COG1126	abc transporter atp-binding protein
H5P29_RS29035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5P29_RS29070	COG0559	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS29080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5P29_RS29085	COG0720	synthase
H5P29_RS29095	COG5001	Diguanylate cyclase
H5P29_RS29110	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H5P29_RS29125	COG1921	L-seryl-tRNASec selenium transferase activity
H5P29_RS29140	COG3964	amidohydrolase
H5P29_RS29150	COG0601	transmembrane transport
H5P29_RS29155	COG0747	negative chemotaxis
H5P29_RS29170	COG1177	transmembrane transport
H5P29_RS29185	COG1840	ABC-type Fe3 transport system, periplasmic component
H5P29_RS29190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5P29_RS29200	COG0583	DNA-binding transcription factor activity
H5P29_RS29205	COG1129	ABC transporter
H5P29_RS29215	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS29230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5P29_RS29235	COG1940	carbohydrate kinase activity
H5P29_RS29245	COG0517	IMP dehydrogenase activity
H5P29_RS29245	COG4175	Glycine betaine
H5P29_RS29250	COG4176	ABC-type proline glycine betaine transport system permease component
H5P29_RS29260	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H5P29_RS29280	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS29285	COG0583	DNA-binding transcription factor activity
H5P29_RS29295	COG3806	Anti-sigma factor
H5P29_RS29300	COG1595	DNA-templated transcription, initiation
H5P29_RS29315	COG0300	oxidoreductase activity
H5P29_RS29345	COG2188	Transcriptional regulator
H5P29_RS29355	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H5P29_RS29355	COG1940	carbohydrate kinase activity
H5P29_RS29365	COG1175	transmembrane transport
H5P29_RS29370	COG0395	ABC-type sugar transport system, permease component
H5P29_RS29380	COG0235	Class ii aldolase
H5P29_RS29385	COG3254	rhamnose metabolic process
H5P29_RS29390	COG4952	isomerase
H5P29_RS29400	COG1070	Carbohydrate kinase
H5P29_RS29415	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS29420	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS29425	COG1129	ABC transporter
H5P29_RS29440	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS29440	COG3347	Dehydrogenase
H5P29_RS29445	COG2390	Transcriptional regulator
H5P29_RS29450	COG0500	methyltransferase
H5P29_RS29460	COG1414	Transcriptional regulator
H5P29_RS29465	COG1475	DNA binding
H5P29_RS29470	COG1192	Involved in chromosome partitioning
H5P29_RS29475	COG3831	ATPase activity
H5P29_RS29485	COG0277	FAD linked oxidase domain protein
H5P29_RS29495	COG0604	alcohol dehydrogenase
H5P29_RS29500	COG1024	Enoyl-CoA hydratase
H5P29_RS29520	COG3842	ATPase activity
H5P29_RS29525	COG1176	ABC-type spermidine putrescine transport system, permease component I
H5P29_RS29530	COG4208	sulfate ABC transporter
H5P29_RS29540	COG0765	amino acid transport
H5P29_RS29600	COG5342	invasion associated locus B
H5P29_RS29605	COG1674	ftsk spoiiie
H5P29_RS29610	COG5001	Diguanylate cyclase
H5P29_RS29660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5P29_RS29680	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H5P29_RS29685	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H5P29_RS29690	COG3842	ATPase activity
H5P29_RS29715	COG2390	Transcriptional regulator
H5P29_RS29725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H5P29_RS29735	COG3732	PTS system glucitol sorbitol-specific
H5P29_RS29755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5P29_RS29765	COG1177	transmembrane transport
H5P29_RS29775	COG3842	ATPase activity
H5P29_RS29790	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5P29_RS29795	COG0022	dehydrogenase e1 component
H5P29_RS29795	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5P29_RS29800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H5P29_RS29810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5P29_RS29875	COG0739	heme binding
H5P29_RS29875	COG0741	lytic transglycosylase activity
H5P29_RS29875	COG1196	nuclear chromosome segregation
H5P29_RS29885	COG1028	Short-chain dehydrogenase reductase Sdr
H5P29_RS29895	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H5P29_RS29915	COG1013	pyruvate-flavodoxin oxidoreductase activity
H5P29_RS29935	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS29965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5P29_RS29970	COG4608	Belongs to the ABC transporter superfamily
H5P29_RS29975	COG0444	Belongs to the ABC transporter superfamily
H5P29_RS29990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS29995	COG0667	Aldo Keto reductase
H5P29_RS30000	COG0747	negative chemotaxis
H5P29_RS30005	COG1414	Transcriptional regulator
H5P29_RS30030	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS30035	COG4608	Belongs to the ABC transporter superfamily
H5P29_RS30045	COG0601	transmembrane transport
H5P29_RS30050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS30060	COG0747	negative chemotaxis
H5P29_RS30065	COG0583	DNA-binding transcription factor activity
H5P29_RS30070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5P29_RS30075	COG1942	4-Oxalocrotonate Tautomerase
H5P29_RS30095	COG1349	DNA-binding transcription factor activity
H5P29_RS30125	COG3795	YCII-related domain
H5P29_RS30140	COG0583	DNA-binding transcription factor activity
H5P29_RS30150	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H5P29_RS30160	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS30180	COG3842	ATPase activity
H5P29_RS30190	COG1176	ABC-type spermidine putrescine transport system, permease component I
H5P29_RS30210	COG1840	ABC-type Fe3 transport system, periplasmic component
H5P29_RS30215	COG3842	ATPase activity
H5P29_RS30225	COG0625	glutathione transferase activity
H5P29_RS30235	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H5P29_RS30245	COG1522	sequence-specific DNA binding
H5P29_RS30270	COG0531	amino acid
H5P29_RS30325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H5P29_RS30330	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H5P29_RS30345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H5P29_RS30345	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5P29_RS30355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5P29_RS30365	COG0069	glutamate synthase activity
H5P29_RS30370	COG2218	PFAM glutamate synthase alpha subunit domain protein
H5P29_RS30375	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H5P29_RS30430	COG2379	hydroxypyruvate reductase
H5P29_RS30435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5P29_RS30440	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H5P29_RS30445	COG0045	succinate-CoA ligase (ADP-forming) activity
H5P29_RS30465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5P29_RS30470	COG1957	nucleoside hydrolase
H5P29_RS30480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H5P29_RS30545	COG1271	oxidase subunit
H5P29_RS30550	COG1294	oxidase, subunit
H5P29_RS30565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5P29_RS30570	COG2986	histidine ammonia-lyase
H5P29_RS30575	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H5P29_RS30585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H5P29_RS30615	COG1120	ATPase activity
H5P29_RS30620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5P29_RS30630	COG4206	TonB-dependent receptor
H5P29_RS30645	COG3483	tryptophan 2,3-dioxygenase activity
H5P29_RS30665	COG0411	ABC transporter
H5P29_RS30680	COG4120	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS30695	COG1802	Transcriptional regulator
H5P29_RS30700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H5P29_RS30710	COG4977	sequence-specific DNA binding
H5P29_RS30715	COG1335	isochorismatase
H5P29_RS30730	COG1024	Enoyl-CoA hydratase
H5P29_RS30735	COG1960	acyl-CoA dehydrogenase activity
H5P29_RS30750	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5P29_RS30750	COG1024	Enoyl-CoA hydratase
H5P29_RS30755	COG0183	Belongs to the thiolase family
H5P29_RS30760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5P29_RS30770	COG0165	Argininosuccinate lyase
H5P29_RS30775	COG0395	ABC-type sugar transport system, permease component
H5P29_RS30780	COG1175	transmembrane transport
H5P29_RS30785	COG2182	Extracellular solute-binding protein
H5P29_RS30790	COG1940	carbohydrate kinase activity
H5P29_RS30810	COG1522	sequence-specific DNA binding
H5P29_RS30815	COG0406	alpha-ribazole phosphatase activity
H5P29_RS30820	COG3842	ATPase activity
H5P29_RS30825	COG4149	molybdate abc transporter
H5P29_RS30850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5P29_RS30855	COG1917	Cupin 2, conserved barrel domain protein
H5P29_RS30860	COG5285	phytanoyl-CoA dioxygenase
H5P29_RS30865	COG0527	aspartate kinase activity
H5P29_RS30870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5P29_RS30875	COG0765	amino acid transport
H5P29_RS30880	COG0765	amino acid transport
H5P29_RS30885	COG1126	abc transporter atp-binding protein
H5P29_RS30900	COG4191	Histidine kinase
H5P29_RS30905	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H5P29_RS30910	COG1802	Transcriptional regulator
H5P29_RS30915	COG3938	Belongs to the proline racemase family
H5P29_RS30920	COG1476	TRANSCRIPTIONal
H5P29_RS30925	COG0747	negative chemotaxis
H5P29_RS30930	COG0601	transmembrane transport
H5P29_RS30935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS30940	COG0444	Belongs to the ABC transporter superfamily
H5P29_RS30945	COG4608	Belongs to the ABC transporter superfamily
H5P29_RS30950	COG0006	proline dipeptidase activity
H5P29_RS30970	COG1846	Transcriptional regulator
H5P29_RS30990	COG0179	Fumarylacetoacetate (FAA) hydrolase
H5P29_RS30995	COG3971	2-oxopent-4-enoate hydratase activity
H5P29_RS31005	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS31015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5P29_RS31020	COG0601	transmembrane transport
H5P29_RS31030	COG2186	Transcriptional regulator
H5P29_RS31060	COG2159	amidohydrolase
H5P29_RS31065	COG3384	dioxygenase
H5P29_RS31075	COG0473	3-isopropylmalate dehydrogenase activity
H5P29_RS31075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5P29_RS31080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5P29_RS31085	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H5P29_RS31085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H5P29_RS31090	COG1960	acyl-CoA dehydrogenase activity
H5P29_RS31095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H5P29_RS31100	COG2030	dehydratase
H5P29_RS31115	COG4584	PFAM Integrase catalytic
H5P29_RS31185	COG0741	lytic transglycosylase activity
H5P29_RS31190	COG3838	Conjugal transfer protein Trbc
H5P29_RS31200	COG3451	type IV secretory pathway VirB4
H5P29_RS31205	COG0741	lytic transglycosylase activity
H5P29_RS31220	COG3736	Type IV secretory pathway, component VirB8
H5P29_RS31225	COG3504	Conjugal transfer protein
H5P29_RS31230	COG2948	multi-organism process
H5P29_RS31235	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
H5P29_RS31250	COG5642	Protein of unknown function (DUF2384)
H5P29_RS31300	COG3831	ATPase activity
H5P29_RS31415	COG1414	Transcriptional regulator
H5P29_RS31420	COG1475	DNA binding
H5P29_RS31425	COG1192	Involved in chromosome partitioning
H5P29_RS31455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H5P29_RS31465	COG1074	ATP-dependent DNA helicase activity
H5P29_RS31525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H5P29_RS31530	COG1309	transcriptional regulator
H5P29_RS31535	COG0318	PFAM AMP-dependent synthetase and ligase
H5P29_RS31565	COG0559	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS31570	COG4214	carbohydrate transport
H5P29_RS31590	COG4644	lycopene metabolic process
H5P29_RS31605	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H5P29_RS31605	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H5P29_RS31610	COG4770	biotin carboxylase activity
H5P29_RS31625	COG1396	sequence-specific DNA binding
H5P29_RS31625	COG3800	Transcriptional regulator
H5P29_RS31630	COG1522	sequence-specific DNA binding
H5P29_RS31650	COG2197	response regulator
H5P29_RS31665	COG1137	ATPase activity
H5P29_RS31700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5P29_RS31705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5P29_RS31720	COG3547	Transposase (IS116 IS110 IS902 family)
H5P29_RS31790	COG0154	amidase activity
H5P29_RS31800	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5P29_RS31830	COG3831	ATPase activity
H5P29_RS31835	COG4227	nucleotidyltransferase activity
H5P29_RS31840	COG5489	Protein of unknown function (DUF736)
H5P29_RS31860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H5P29_RS31885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H5P29_RS31890	COG4959	Type IV secretory pathway protease TraF
H5P29_RS31910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H5P29_RS31980	COG3701	Conjugal transfer protein
H5P29_RS31985	COG3846	protein secretion by the type IV secretion system
H5P29_RS31995	COG5314	conjugation
H5P29_RS32000	COG3451	type IV secretory pathway VirB4
H5P29_RS32005	COG5268	conjugation
H5P29_RS32010	COG3838	Conjugal transfer protein Trbc
H5P29_RS32015	COG4962	Type ii secretion system protein e
H5P29_RS32020	COG3916	Acyl-homoserine-lactone synthase
H5P29_RS32030	COG3177	Filamentation induced by cAMP protein fic
H5P29_RS32040	COG1192	Involved in chromosome partitioning
H5P29_RS32045	COG1475	DNA binding
H5P29_RS32050	COG0640	Transcriptional regulator
H5P29_RS32060	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H5P29_RS32075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5P29_RS32105	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H5P29_RS32145	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H5P29_RS32155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H5P29_RS32160	COG3842	ATPase activity
H5P29_RS32165	COG1653	transport
H5P29_RS32170	COG1175	transmembrane transport
H5P29_RS32175	COG0395	ABC-type sugar transport system, permease component
H5P29_RS32195	COG0277	FAD linked oxidase domain protein
H5P29_RS32200	COG0625	glutathione transferase activity
H5P29_RS32205	COG0318	PFAM AMP-dependent synthetase and ligase
H5P29_RS32210	COG1012	belongs to the aldehyde dehydrogenase family
H5P29_RS32220	COG1454	alcohol dehydrogenase
H5P29_RS32230	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H5P29_RS32235	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H5P29_RS32295	COG1475	DNA binding