locus-tag	class	description
CO731_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CO731_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CO731_RS00040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO731_RS00050	COG0735	belongs to the Fur family
CO731_RS00055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CO731_RS00065	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CO731_RS00070	COG3300	MHYT domain
CO731_RS00070	COG5001	Diguanylate cyclase
CO731_RS00075	COG2813	Specifically methylates the guanine in position
CO731_RS00080	COG1185	polyribonucleotide nucleotidyltransferase activity
CO731_RS00085	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CO731_RS00090	COG0598	Magnesium transport protein CorA
CO731_RS00095	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CO731_RS00100	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CO731_RS00105	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CO731_RS00120	COG0779	Required for maturation of 30S ribosomal subunits
CO731_RS00155	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CO731_RS00160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CO731_RS00165	COG1396	sequence-specific DNA binding
CO731_RS00170	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CO731_RS00180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CO731_RS00185	COG1702	phosphate starvation-inducible protein PhoH
CO731_RS00190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CO731_RS00195	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CO731_RS00215	COG1214	PFAM Peptidase M22, glycoprotease
CO731_RS00225	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CO731_RS00255	COG2827	Endonuclease containing a URI domain
CO731_RS00260	COG0481	GTPase activity
CO731_RS00305	COG2827	Endonuclease containing a URI domain
CO731_RS00325	COG0671	phosphoesterase, PA-phosphatase related
CO731_RS00335	COG0659	secondary active sulfate transmembrane transporter activity
CO731_RS00340	COG0443	Heat shock 70 kDa protein
CO731_RS00360	COG3795	YCII-related domain
CO731_RS00395	COG0640	Transcriptional regulator
CO731_RS00400	COG0625	glutathione transferase activity
CO731_RS00415	COG2358	TRAP transporter, solute receptor (TAXI family
CO731_RS00420	COG0842	Transport permease protein
CO731_RS00425	COG1131	(ABC) transporter
CO731_RS00440	COG2954	triphosphatase activity
CO731_RS00465	COG1420	regulation of RNA biosynthetic process
CO731_RS00470	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CO731_RS00480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CO731_RS00485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CO731_RS00500	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CO731_RS00505	COG0792	nuclease activity
CO731_RS00515	COG1254	Belongs to the acylphosphatase family
CO731_RS00520	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CO731_RS00525	COG2124	cytochrome p450
CO731_RS00540	COG3920	Histidine kinase
CO731_RS00555	COG0024	Methionine aminopeptidase
CO731_RS00565	COG2205	protein histidine kinase activity
CO731_RS00570	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CO731_RS00575	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CO731_RS00580	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CO731_RS00595	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CO731_RS00610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CO731_RS00615	COG2226	methyltransferase
CO731_RS00620	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CO731_RS00625	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CO731_RS00645	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CO731_RS00665	COG1079	Belongs to the binding-protein-dependent transport system permease family
CO731_RS00670	COG1079	Belongs to the binding-protein-dependent transport system permease family
CO731_RS00675	COG3845	ABC transporter
CO731_RS00680	COG2900	Belongs to the SlyX family
CO731_RS00690	COG1744	ABC transporter substrate-binding protein PnrA-like
CO731_RS00695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO731_RS00720	COG0583	DNA-binding transcription factor activity
CO731_RS00725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CO731_RS00735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CO731_RS00740	COG4948	Mandelate Racemase Muconate Lactonizing
CO731_RS00745	COG4172	Belongs to the ABC transporter superfamily
CO731_RS00750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS00755	COG0601	transmembrane transport
CO731_RS00760	COG4166	transmembrane transport
CO731_RS00770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_RS00775	COG1473	amidohydrolase
CO731_RS00780	COG4166	transmembrane transport
CO731_RS00850	COG0395	ABC-type sugar transport system, permease component
CO731_RS00855	COG1175	transmembrane transport
CO731_RS00870	COG1765	OsmC-like protein
CO731_RS00875	COG2766	serine protein kinase
CO731_RS00880	COG2718	Belongs to the UPF0229 family
CO731_RS00885	COG2719	SpoVR family
CO731_RS00890	COG3142	Participates in the control of copper homeostasis
CO731_RS00895	COG1940	carbohydrate kinase activity
CO731_RS00905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_RS00910	COG1446	asparaginase
CO731_RS00920	COG0765	amino acid transport
CO731_RS00925	COG0765	amino acid transport
CO731_RS00995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CO731_RS01000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CO731_RS01005	COG1280	lysine exporter protein (LysE YggA)
CO731_RS01010	COG1957	nucleoside hydrolase
CO731_RS01025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO731_RS01030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CO731_RS01035	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CO731_RS01040	COG1137	ATPase activity
CO731_RS01045	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CO731_RS01055	COG0616	signal peptide processing
CO731_RS01060	COG0776	regulation of translation
CO731_RS01070	COG2423	ornithine cyclodeaminase activity
CO731_RS01075	COG0116	Belongs to the methyltransferase superfamily
CO731_RS01075	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CO731_RS01085	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CO731_RS01115	COG1252	NADH dehydrogenase
CO731_RS01125	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CO731_RS01140	COG0175	sulfate reduction
CO731_RS01145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CO731_RS01155	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CO731_RS01155	COG1648	precorrin-2 dehydrogenase activity
CO731_RS01165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CO731_RS01165	COG4651	solute:proton antiporter activity
CO731_RS01175	COG1846	Transcriptional regulator
CO731_RS01185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CO731_RS01220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO731_RS01235	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO731_RS01235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO731_RS01240	COG1280	lysine exporter protein (LysE YggA)
CO731_RS01250	COG0667	Aldo Keto reductase
CO731_RS01255	COG0673	inositol 2-dehydrogenase activity
CO731_RS01270	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CO731_RS01280	COG1609	Transcriptional regulator
CO731_RS01285	COG1653	transport
CO731_RS01290	COG1175	transmembrane transport
CO731_RS01295	COG0395	ABC-type sugar transport system, permease component
CO731_RS01300	COG0366	Alpha amylase catalytic
CO731_RS01305	COG3842	ATPase activity
CO731_RS01310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO731_RS01315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO731_RS01320	COG1121	(ABC) transporter
CO731_RS01325	COG0803	Belongs to the bacterial solute-binding protein 9 family
CO731_RS01340	COG1404	Belongs to the peptidase S8 family
CO731_RS01350	COG1595	DNA-templated transcription, initiation
CO731_RS01360	COG0444	Belongs to the ABC transporter superfamily
CO731_RS01365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS01375	COG0747	negative chemotaxis
CO731_RS01380	COG2936	dipeptidyl-peptidase activity
CO731_RS01385	COG1309	transcriptional regulator
CO731_RS01470	COG4974	Belongs to the 'phage' integrase family
CO731_RS01480	COG0444	Belongs to the ABC transporter superfamily
CO731_RS01485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS01500	COG2814	Major facilitator Superfamily
CO731_RS01535	COG2814	Major facilitator Superfamily
CO731_RS01575	COG0583	DNA-binding transcription factor activity
CO731_RS01585	COG0251	oxidation-reduction process
CO731_RS01610	COG0583	DNA-binding transcription factor activity
CO731_RS01615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS01685	COG0765	amino acid transport
CO731_RS01690	COG0765	amino acid transport
CO731_RS01695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_RS01700	COG1126	abc transporter atp-binding protein
CO731_RS01715	COG2072	flavoprotein involved in K transport
CO731_RS01720	COG0583	DNA-binding transcription factor activity
CO731_RS01755	COG0577	efflux transmembrane transporter activity
CO731_RS01755	COG1136	(ABC) transporter
CO731_RS01805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS01810	COG0601	transmembrane transport
CO731_RS01830	COG2197	response regulator
CO731_RS01840	COG0583	DNA-binding transcription factor activity
CO731_RS01880	COG3451	type IV secretory pathway VirB4
CO731_RS01890	COG3838	Conjugal transfer protein Trbc
CO731_RS01895	COG4962	Type ii secretion system protein e
CO731_RS01975	COG5489	Protein of unknown function (DUF736)
CO731_RS02055	COG1072	(Pantothenic acid kinase))
CO731_RS02065	COG0625	glutathione transferase activity
CO731_RS02080	COG0829	nickel cation binding
CO731_RS02085	COG0831	urea catabolic process
CO731_RS02090	COG3813	Protein conserved in bacteria
CO731_RS02095	COG0832	Belongs to the urease beta subunit family
CO731_RS02115	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CO731_RS02120	COG0830	nickel cation binding
CO731_RS02130	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CO731_RS02140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO731_RS02150	COG0583	DNA-binding transcription factor activity
CO731_RS02155	COG0534	Mate efflux family protein
CO731_RS02165	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_RS02170	COG3842	ATPase activity
CO731_RS02180	COG0765	amino acid transport
CO731_RS02185	COG0765	amino acid transport
CO731_RS02200	COG0583	DNA-binding transcription factor activity
CO731_RS02205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CO731_RS02220	COG0559	Belongs to the binding-protein-dependent transport system permease family
CO731_RS02230	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CO731_RS02245	COG1335	isochorismatase
CO731_RS02255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CO731_RS02275	COG1846	Transcriptional regulator
CO731_RS02280	COG1012	belongs to the aldehyde dehydrogenase family
CO731_RS02285	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CO731_RS02310	COG0673	inositol 2-dehydrogenase activity
CO731_RS02315	COG0395	ABC-type sugar transport system, permease component
CO731_RS02320	COG1175	transmembrane transport
CO731_RS02330	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CO731_RS02335	COG2971	BadF BadG BcrA BcrD
CO731_RS02340	COG2188	Transcriptional regulator
CO731_RS02350	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CO731_RS02370	COG1879	ABC-type sugar transport system periplasmic component
CO731_RS02375	COG1129	ABC transporter
CO731_RS02380	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_RS02385	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_RS02390	COG1609	Transcriptional regulator
CO731_RS02400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CO731_RS02410	COG4941	Belongs to the sigma-70 factor family
CO731_RS02415	COG3795	YCII-related domain
CO731_RS02420	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CO731_RS02460	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CO731_RS02465	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CO731_RS02470	COG4335	DNA alkylation repair
CO731_RS02500	COG0121	glutamine amidotransferase
CO731_RS02505	COG0756	dUTP diphosphatase activity
CO731_RS02510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO731_RS02515	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CO731_RS02525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CO731_RS02550	COG0280	phosphate acetyltransferase
CO731_RS02550	COG0281	malic enzyme
CO731_RS02555	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CO731_RS02600	COG0596	Alpha beta hydrolase
CO731_RS02605	COG2207	Transcriptional regulator
CO731_RS02605	COG0662	Cupin 2, conserved barrel domain protein
CO731_RS02615	COG1309	transcriptional regulator
CO731_RS02635	COG5001	Diguanylate cyclase
CO731_RS02635	COG5002	protein histidine kinase activity
CO731_RS02645	COG0656	L-ascorbic acid biosynthetic process
CO731_RS02660	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CO731_RS02665	COG0728	peptidoglycan biosynthetic process
CO731_RS02670	COG0180	Tryptophanyl-tRNA synthetase
CO731_RS02680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CO731_RS02685	COG1376	ErfK ybiS ycfS ynhG family protein
CO731_RS02695	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CO731_RS02705	COG1643	Atp-dependent helicase
CO731_RS02730	COG0673	inositol 2-dehydrogenase activity
CO731_RS02735	COG1737	Transcriptional regulator
CO731_RS02740	COG0129	dihydroxy-acid dehydratase activity
CO731_RS02750	COG0626	cystathionine gamma-synthase activity
CO731_RS02755	COG1846	Transcriptional regulator
CO731_RS02760	COG0697	spore germination
CO731_RS02765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_RS02770	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CO731_RS02775	COG4521	taurine ABC transporter
CO731_RS02785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CO731_RS02790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CO731_RS02800	COG1137	ATPase activity
CO731_RS02820	COG0683	leucine binding
CO731_RS02835	COG3485	protocatechuate 3,4-dioxygenase
CO731_RS02840	COG3485	protocatechuate 3,4-dioxygenase
CO731_RS02845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CO731_RS02850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CO731_RS02855	COG0583	DNA-binding transcription factor activity
CO731_RS02860	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS02865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CO731_RS02870	COG1802	Transcriptional regulator
CO731_RS02875	COG0579	oxidoreductase
CO731_RS02885	COG1522	sequence-specific DNA binding
CO731_RS02890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CO731_RS02895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_RS02905	COG0741	lytic transglycosylase activity
CO731_RS02905	COG1196	nuclear chromosome segregation
CO731_RS02905	COG0739	heme binding
CO731_RS02930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO731_RS02940	COG3395	kinase activity
CO731_RS02945	COG4608	Belongs to the ABC transporter superfamily
CO731_RS02950	COG0444	Belongs to the ABC transporter superfamily
CO731_RS02955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS02965	COG0747	negative chemotaxis
CO731_RS02970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CO731_RS02975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO731_RS02985	COG1454	alcohol dehydrogenase
CO731_RS03020	COG1022	Amp-dependent synthetase and ligase
CO731_RS03030	COG0861	Integral membrane protein TerC family
CO731_RS03085	COG0156	8-amino-7-oxononanoate synthase activity
CO731_RS03090	COG1063	alcohol dehydrogenase
CO731_RS03100	COG4608	Belongs to the ABC transporter superfamily
CO731_RS03110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS03115	COG0601	transmembrane transport
CO731_RS03130	COG2186	Transcriptional regulator
CO731_RS03145	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CO731_RS03150	COG0400	carboxylic ester hydrolase activity
CO731_RS03160	COG2124	cytochrome p450
CO731_RS03175	COG4206	TonB-dependent receptor
CO731_RS03190	COG1120	ATPase activity
CO731_RS03205	COG0848	biopolymer transport protein
CO731_RS03250	COG1082	Xylose isomerase domain protein TIM barrel
CO731_RS03255	COG4607	ABC-type enterochelin transport system periplasmic component
CO731_RS03260	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO731_RS03265	COG4605	iron ion homeostasis
CO731_RS03270	COG4604	ABC transporter, ATP-binding protein
CO731_RS03280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CO731_RS03300	COG0559	Belongs to the binding-protein-dependent transport system permease family
CO731_RS03310	COG2271	Major facilitator Superfamily
CO731_RS03315	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS03330	COG4638	Rieske (2fe-2S)
CO731_RS03355	COG0640	Transcriptional regulator
CO731_RS03360	COG0798	PFAM Bile acid sodium symporter
CO731_RS03370	COG0431	NADPH-dependent FMN reductase
CO731_RS03380	COG4974	Belongs to the 'phage' integrase family
CO731_RS03455	COG4957	zinc ion binding
CO731_RS03460	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CO731_RS03480	COG1953	Uracil, thiamine, allantoin
CO731_RS03505	COG0583	DNA-binding transcription factor activity
CO731_RS03540	COG2801	Transposase and inactivated derivatives
CO731_RS03555	COG3436	PFAM IS66 Orf2 family protein
CO731_RS03570	COG0006	proline dipeptidase activity
CO731_RS03580	COG1129	ABC transporter
CO731_RS03585	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_RS03620	COG2801	Transposase and inactivated derivatives
CO731_RS03630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_RS03630	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO731_RS03645	COG4977	sequence-specific DNA binding
CO731_RS03695	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_RS03705	COG0583	DNA-binding transcription factor activity
CO731_RS03735	COG0010	Belongs to the arginase family
CO731_RS03755	COG0583	DNA-binding transcription factor activity
CO731_RS03760	COG2423	ornithine cyclodeaminase activity
CO731_RS03765	COG3616	Alanine racemase, N-terminal domain
CO731_RS03770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CO731_RS03775	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CO731_RS03795	COG0402	S-adenosylhomocysteine deaminase activity
CO731_RS03800	COG3842	ATPase activity
CO731_RS03810	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_RS03865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CO731_RS03870	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS03875	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CO731_RS03880	COG0539	negative regulation of cytoplasmic translation
CO731_RS03900	COG1309	transcriptional regulator
CO731_RS03925	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CO731_RS03935	COG3237	CsbD-like
CO731_RS03945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CO731_RS03950	COG1968	undecaprenyl-diphosphatase activity
CO731_RS03960	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CO731_RS03970	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CO731_RS03975	COG1803	Methylglyoxal synthase
CO731_RS03980	COG0837	glucose binding
CO731_RS03985	COG1132	(ABC) transporter
CO731_RS03990	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CO731_RS03995	COG0588	phosphoglycerate mutase activity
CO731_RS04005	COG0463	Glycosyl transferase, family 2
CO731_RS04010	COG1295	ribonuclease BN
CO731_RS04035	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CO731_RS04045	COG3386	PFAM SMP-30 Gluconolaconase
CO731_RS04050	COG0800	Aldolase
CO731_RS04055	COG3734	2-keto-3-deoxy-galactonokinase
CO731_RS04060	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS04065	COG5001	Diguanylate cyclase
CO731_RS04070	COG0189	ligase activity
CO731_RS04080	COG5001	Diguanylate cyclase
CO731_RS04270	COG0305	Participates in initiation and elongation during chromosome replication
CO731_RS04305	COG4974	Belongs to the 'phage' integrase family
CO731_RS04335	COG0284	orotidine-5'-phosphate decarboxylase activity
CO731_RS04345	COG3963	phosphatidate phosphatase activity
CO731_RS04350	COG0484	heat shock protein binding
CO731_RS04355	COG0443	Heat shock 70 kDa protein
CO731_RS04390	COG0072	phenylalanine-tRNA ligase activity
CO731_RS04390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO731_RS04400	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CO731_RS04405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CO731_RS04410	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CO731_RS04420	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CO731_RS04430	COG3135	benzoate transporter
CO731_RS04445	COG0135	phosphoribosylanthranilate isomerase activity
CO731_RS04450	COG0133	tryptophan synthase activity
CO731_RS04455	COG0159	tryptophan synthase activity
CO731_RS04460	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CO731_RS04475	COG1074	ATP-dependent DNA helicase activity
CO731_RS04480	COG2887	Belongs to the helicase family. UvrD subfamily
CO731_RS04485	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CO731_RS04490	COG3178	'Phosphotransferase
CO731_RS04495	COG2205	protein histidine kinase activity
CO731_RS04500	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CO731_RS04505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO731_RS04510	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO731_RS04510	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO731_RS04520	COG2205	protein histidine kinase activity
CO731_RS04525	COG0745	RESPONSE REGULATOR receiver
CO731_RS04530	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CO731_RS04540	COG1652	LysM domain
CO731_RS04550	COG1072	(Pantothenic acid kinase))
CO731_RS04555	COG0140	phosphoribosyl-ATP diphosphatase activity
CO731_RS04560	COG0107	imidazoleglycerol-phosphate synthase activity
CO731_RS04565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CO731_RS04570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CO731_RS04580	COG0131	Imidazoleglycerol-phosphate dehydratase
CO731_RS04585	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CO731_RS04605	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CO731_RS04615	COG1396	sequence-specific DNA binding
CO731_RS04615	COG3800	Transcriptional regulator
CO731_RS04640	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CO731_RS04645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CO731_RS04650	COG0237	dephospho-CoA kinase activity
CO731_RS04655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CO731_RS04660	COG0424	maF-like protein
CO731_RS04665	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CO731_RS04670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CO731_RS04675	COG1981	membrane
CO731_RS04680	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CO731_RS04685	COG1331	Highly conserved protein containing a thioredoxin domain
CO731_RS04690	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CO731_RS04695	COG0445	tRNA wobble uridine modification
CO731_RS04700	COG0357	Ribosomal RNA small subunit methyltransferase G
CO731_RS04770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CO731_RS04780	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CO731_RS04780	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CO731_RS04790	COG4770	biotin carboxylase activity
CO731_RS04795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CO731_RS04800	COG1268	BioY protein
CO731_RS04805	COG1396	sequence-specific DNA binding
CO731_RS04805	COG3800	Transcriptional regulator
CO731_RS04815	COG2183	response to ionizing radiation
CO731_RS04820	COG0137	argininosuccinate synthase activity
CO731_RS04855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CO731_RS04860	COG0287	Prephenate dehydrogenase
CO731_RS04860	COG1605	Chorismate mutase
CO731_RS04865	COG0228	four-way junction DNA binding
CO731_RS04875	COG3781	membrane
CO731_RS04885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CO731_RS04900	COG4178	(ABC) transporter
CO731_RS04905	COG3152	Membrane
CO731_RS04910	COG0473	3-isopropylmalate dehydrogenase activity
CO731_RS04925	COG0251	oxidation-reduction process
CO731_RS04935	COG0066	3-isopropylmalate dehydratase activity
CO731_RS04940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CO731_RS04945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO731_RS04950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO731_RS04970	COG2814	Major facilitator Superfamily
CO731_RS05030	COG1278	Cold shock
CO731_RS05050	COG2301	Belongs to the HpcH HpaI aldolase family
CO731_RS05075	COG0587	DNA-directed DNA polymerase activity
CO731_RS05080	COG2835	tetraacyldisaccharide 4'-kinase activity
CO731_RS05085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CO731_RS05090	COG3118	belongs to the thioredoxin family
CO731_RS05105	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS05110	COG4948	Mandelate Racemase Muconate Lactonizing
CO731_RS05115	COG0179	Fumarylacetoacetate (FAA) hydrolase
CO731_RS05125	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_RS05130	COG1129	ABC transporter
CO731_RS05140	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS05155	COG4608	Belongs to the ABC transporter superfamily
CO731_RS05160	COG0444	Belongs to the ABC transporter superfamily
CO731_RS05165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS05170	COG0601	transmembrane transport
CO731_RS05175	COG0747	negative chemotaxis
CO731_RS05185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CO731_RS05200	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CO731_RS05210	COG0456	acetyltransferase
CO731_RS05220	COG3339	Conserved Protein
CO731_RS05225	COG2154	pterin-4-alpha-carbinolamine dehydratase
CO731_RS05230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CO731_RS05235	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CO731_RS05245	COG1136	(ABC) transporter
CO731_RS05255	COG0670	Belongs to the BI1 family
CO731_RS05265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CO731_RS05270	COG1012	belongs to the aldehyde dehydrogenase family
CO731_RS05295	COG3300	MHYT domain
CO731_RS05295	COG5001	Diguanylate cyclase
CO731_RS05330	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CO731_RS05340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CO731_RS05345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CO731_RS05350	COG0552	protein localization to endoplasmic reticulum
CO731_RS05355	COG2917	probably involved in intracellular septation
CO731_RS05370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO731_RS05380	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CO731_RS05385	COG4133	protoheme IX ABC transporter activity
CO731_RS05390	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CO731_RS05400	COG0039	L-malate dehydrogenase activity
CO731_RS05405	COG0045	succinate-CoA ligase (ADP-forming) activity
CO731_RS05410	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CO731_RS05415	COG0567	Dehydrogenase, E1 component
CO731_RS05420	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO731_RS05435	COG1280	lysine exporter protein (LysE YggA)
CO731_RS05445	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS05470	COG4974	Belongs to the 'phage' integrase family
CO731_RS05475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CO731_RS05490	COG0336	Belongs to the RNA methyltransferase TrmD family
CO731_RS05510	COG0335	large ribosomal subunit rRNA binding
CO731_RS05520	COG0765	amino acid transport
CO731_RS05525	COG2226	methyltransferase
CO731_RS05540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CO731_RS05555	COG2009	succinate dehydrogenase
CO731_RS05585	COG3132	Protein of unknown function, DUF480
CO731_RS05600	COG1764	response to oxidative stress
CO731_RS05605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CO731_RS05610	COG1946	Acyl-CoA thioesterase
CO731_RS05615	COG0347	Belongs to the P(II) protein family
CO731_RS05620	COG0004	ammonium transporteR
CO731_RS05645	COG1674	ftsk spoiiie
CO731_RS05645	COG2261	transglycosylase associated protein
CO731_RS05650	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CO731_RS05665	COG0745	RESPONSE REGULATOR receiver
CO731_RS05680	COG0583	DNA-binding transcription factor activity
CO731_RS05700	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CO731_RS05705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CO731_RS05710	COG0181	hydroxymethylbilane synthase activity
CO731_RS05750	COG2755	lipolytic protein G-D-S-L family
CO731_RS05750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CO731_RS05760	COG3239	Fatty acid desaturase
CO731_RS05770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CO731_RS05775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CO731_RS05785	COG4176	ABC-type proline glycine betaine transport system permease component
CO731_RS05790	COG3448	diguanylate cyclase activity
CO731_RS05790	COG4175	Glycine betaine
CO731_RS05810	COG1879	ABC-type sugar transport system periplasmic component
CO731_RS05815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_RS05820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CO731_RS05825	COG1012	belongs to the aldehyde dehydrogenase family
CO731_RS05845	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CO731_RS05865	COG1872	DUF167
CO731_RS05875	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CO731_RS05900	COG1704	LemA family
CO731_RS05925	COG2814	Major facilitator Superfamily
CO731_RS05945	COG1217	gtp-binding protein TYPA
CO731_RS05965	COG2270	Major facilitator Superfamily
CO731_RS05970	COG0138	bifunctional purine biosynthesis protein purh
CO731_RS05985	COG0501	Belongs to the peptidase M48B family
CO731_RS06005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CO731_RS06010	COG5425	PFAM Usg family protein
CO731_RS06035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CO731_RS06040	COG0495	leucyl-tRNA aminoacylation
CO731_RS06060	COG1522	sequence-specific DNA binding
CO731_RS06065	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CO731_RS06095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO731_RS06105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CO731_RS06110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CO731_RS06115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CO731_RS06125	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CO731_RS06130	COG1088	dTDP-glucose 4,6-dehydratase activity
CO731_RS06135	COG1091	dTDP-4-dehydrorhamnose reductase activity
CO731_RS06145	COG3754	Rhamnan synthesis protein F
CO731_RS06155	COG3754	Rhamnan synthesis protein F
CO731_RS06160	COG3842	ATPase activity
CO731_RS06165	COG0402	S-adenosylhomocysteine deaminase activity
CO731_RS06170	COG1082	Xylose isomerase domain protein TIM barrel
CO731_RS06180	COG0395	ABC-type sugar transport system, permease component
CO731_RS06185	COG1175	transmembrane transport
CO731_RS06195	COG4608	Belongs to the ABC transporter superfamily
CO731_RS06200	COG0402	S-adenosylhomocysteine deaminase activity
CO731_RS06205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS06215	COG4533	DNA binding
CO731_RS06220	COG0444	Belongs to the ABC transporter superfamily
CO731_RS06245	COG0459	protein refolding
CO731_RS06250	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CO731_RS06270	COG0514	ATP-dependent DNA helicase (RecQ)
CO731_RS06275	COG0582	viral genome integration into host DNA
CO731_RS06370	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CO731_RS06375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CO731_RS06390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CO731_RS06395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CO731_RS06400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CO731_RS06405	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CO731_RS06425	COG0799	negative regulation of ribosome biogenesis
CO731_RS06430	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CO731_RS06440	COG0793	Belongs to the peptidase S41A family
CO731_RS06450	COG0494	nUDIX hydrolase
CO731_RS06455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO731_RS06465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_RS06500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO731_RS06505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_RS06545	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CO731_RS06555	COG2223	nitrite transmembrane transporter activity
CO731_RS06565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CO731_RS06580	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS06595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CO731_RS06600	COG0741	lytic transglycosylase activity
CO731_RS06605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO731_RS06620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO731_RS06625	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CO731_RS06640	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CO731_RS06645	COG0183	Belongs to the thiolase family
CO731_RS06650	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS06655	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO731_RS06670	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CO731_RS06675	COG1329	Transcriptional regulator
CO731_RS06680	COG1126	abc transporter atp-binding protein
CO731_RS06685	COG0765	amino acid transport
CO731_RS06690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_RS06695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CO731_RS06705	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CO731_RS06715	COG4143	(ABC) transporter
CO731_RS06725	COG0488	(ABC) transporter
CO731_RS06745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CO731_RS06755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO731_RS06760	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CO731_RS06775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO731_RS06790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CO731_RS06795	COG0037	tRNA processing
CO731_RS06805	COG2885	chlorophyll binding
CO731_RS06810	COG0823	Involved in the tonB-independent uptake of proteins
CO731_RS06820	COG0848	biopolymer transport protein
CO731_RS06830	COG0824	Thioesterase
CO731_RS06840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO731_RS06840	COG0456	acetyltransferase
CO731_RS06845	COG2255	four-way junction helicase activity
CO731_RS06860	COG0632	four-way junction helicase activity
CO731_RS06880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CO731_RS06900	COG0318	PFAM AMP-dependent synthetase and ligase
CO731_RS06920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CO731_RS06925	COG0483	inositol monophosphate 1-phosphatase activity
CO731_RS06930	COG1272	protein, Hemolysin III
CO731_RS06970	COG1132	(ABC) transporter
CO731_RS06975	COG0254	rRNA binding
CO731_RS06985	COG0702	epimerase
CO731_RS06995	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO731_RS07005	COG0217	transcriptional regulatory protein
CO731_RS07015	COG3706	GGDEF domain
CO731_RS07025	COG1733	regulation of RNA biosynthetic process
CO731_RS07045	COG0305	Participates in initiation and elongation during chromosome replication
CO731_RS07050	COG0861	Integral membrane protein TerC family
CO731_RS07055	COG1692	metallophosphoesterase
CO731_RS07095	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO731_RS07105	COG3750	Belongs to the UPF0335 family
CO731_RS07125	COG0469	pyruvate kinase activity
CO731_RS07130	COG2267	carboxylic ester hydrolase activity
CO731_RS07135	COG0457	Tetratricopeptide repeat
CO731_RS07150	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CO731_RS07170	COG0640	Transcriptional regulator
CO731_RS07185	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS07185	COG0604	alcohol dehydrogenase
CO731_RS07185	COG3321	synthase
CO731_RS07215	COG4191	Histidine kinase
CO731_RS07255	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS07360	COG3588	fructose-bisphosphate aldolase
CO731_RS07365	COG0126	phosphoglycerate kinase activity
CO731_RS07400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CO731_RS07405	COG0564	pseudouridine synthase activity
CO731_RS07415	COG0346	lactoylglutathione lyase activity
CO731_RS07480	COG1525	nuclease
CO731_RS07620	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CO731_RS07670	COG0784	Response regulator, receiver
CO731_RS07670	COG2205	protein histidine kinase activity
CO731_RS07670	COG5002	protein histidine kinase activity
CO731_RS07680	COG0573	inorganic phosphate transmembrane transporter activity
CO731_RS07690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CO731_RS07695	COG0704	Plays a role in the regulation of phosphate uptake
CO731_RS07700	COG0745	RESPONSE REGULATOR receiver
CO731_RS07710	COG1376	ErfK ybiS ycfS ynhG family protein
CO731_RS07730	COG4213	ABC transporter substrate-binding protein
CO731_RS07735	COG4214	carbohydrate transport
CO731_RS07760	COG2202	Pas domain
CO731_RS07760	COG3920	Histidine kinase
CO731_RS07770	COG0784	Response regulator, receiver
CO731_RS07790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO731_RS07840	COG0346	lactoylglutathione lyase activity
CO731_RS07845	COG0400	carboxylic ester hydrolase activity
CO731_RS07860	COG2203	Gaf domain
CO731_RS07860	COG2200	EAL domain
CO731_RS07860	COG2199	diguanylate cyclase activity
CO731_RS07870	COG0745	RESPONSE REGULATOR receiver
CO731_RS07885	COG1178	ABC-type Fe3 transport system permease component
CO731_RS07890	COG3842	ATPase activity
CO731_RS07910	COG0483	inositol monophosphate 1-phosphatase activity
CO731_RS07915	COG0483	inositol monophosphate 1-phosphatase activity
CO731_RS07940	COG1840	ABC-type Fe3 transport system, periplasmic component
CO731_RS07950	COG3842	ATPase activity
CO731_RS07955	COG1238	metal cluster binding
CO731_RS07965	COG2132	Multicopper oxidase
CO731_RS07990	COG2217	Heavy metal translocating P-type atpase
CO731_RS07995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CO731_RS08000	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CO731_RS08010	COG1845	cytochrome c oxidase, subunit III
CO731_RS08040	COG3842	ATPase activity
CO731_RS08045	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CO731_RS08065	COG1079	Belongs to the binding-protein-dependent transport system permease family
CO731_RS08070	COG4603	Belongs to the binding-protein-dependent transport system permease family
CO731_RS08075	COG3845	ABC transporter
CO731_RS08085	COG2186	Transcriptional regulator
CO731_RS08105	COG0625	glutathione transferase activity
CO731_RS08110	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CO731_RS08115	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CO731_RS08130	COG2022	thiamine diphosphate biosynthetic process
CO731_RS08145	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CO731_RS08155	COG0022	dehydrogenase e1 component
CO731_RS08170	COG0356	it plays a direct role in the translocation of protons across the membrane
CO731_RS08195	COG0444	Belongs to the ABC transporter superfamily
CO731_RS08210	COG0747	negative chemotaxis
CO731_RS08215	COG0601	transmembrane transport
CO731_RS08220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS08230	COG0402	S-adenosylhomocysteine deaminase activity
CO731_RS08240	COG3048	D-serine ammonia-lyase activity
CO731_RS08245	COG0583	DNA-binding transcription factor activity
CO731_RS08260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CO731_RS08275	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_RS08290	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CO731_RS08295	COG0582	viral genome integration into host DNA
CO731_RS08375	COG0616	signal peptide processing
CO731_RS08380	COG0433	COG0433 Predicted ATPase
CO731_RS08410	COG1473	amidohydrolase
CO731_RS08415	COG1686	Belongs to the peptidase S11 family
CO731_RS08420	COG0523	cobalamin synthesis protein
CO731_RS08425	COG0425	Belongs to the sulfur carrier protein TusA family
CO731_RS08435	COG0825	malonyl-CoA metabolic process
CO731_RS08450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CO731_RS08455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CO731_RS08460	COG4536	flavin adenine dinucleotide binding
CO731_RS08510	COG1522	sequence-specific DNA binding
CO731_RS08515	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CO731_RS08520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CO731_RS08540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CO731_RS08545	COG2226	methyltransferase
CO731_RS08565	COG0583	DNA-binding transcription factor activity
CO731_RS08570	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CO731_RS08575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CO731_RS08580	COG0287	Prephenate dehydrogenase
CO731_RS08615	COG2884	Cell division ATP-binding protein ftsE
CO731_RS08625	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CO731_RS08630	COG0745	RESPONSE REGULATOR receiver
CO731_RS08640	COG0583	DNA-binding transcription factor activity
CO731_RS08655	COG0019	diaminopimelate decarboxylase activity
CO731_RS08665	COG0165	Argininosuccinate lyase
CO731_RS08670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO731_RS08675	COG1653	transport
CO731_RS08680	COG1175	transmembrane transport
CO731_RS08685	COG0395	ABC-type sugar transport system, permease component
CO731_RS08690	COG3842	ATPase activity
CO731_RS08700	COG1250	3-hydroxyacyl-CoA dehydrogenase
CO731_RS08705	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CO731_RS08710	COG2086	electron transfer activity
CO731_RS08730	COG0300	oxidoreductase activity
CO731_RS08740	COG0697	spore germination
CO731_RS08750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CO731_RS08770	COG1238	metal cluster binding
CO731_RS08780	COG0583	DNA-binding transcription factor activity
CO731_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS08830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CO731_RS08835	COG0183	Belongs to the thiolase family
CO731_RS08845	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CO731_RS08880	COG1309	transcriptional regulator
CO731_RS08885	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS08945	COG0625	glutathione transferase activity
CO731_RS08950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO731_RS08960	COG0583	DNA-binding transcription factor activity
CO731_RS08970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO731_RS09005	COG0583	DNA-binding transcription factor activity
CO731_RS09015	COG2948	multi-organism process
CO731_RS09030	COG3846	protein secretion by the type IV secretion system
CO731_RS09045	COG3451	type IV secretory pathway VirB4
CO731_RS09060	COG4962	Type ii secretion system protein e
CO731_RS09080	COG0741	lytic transglycosylase activity
CO731_RS09105	COG1192	Involved in chromosome partitioning
CO731_RS09135	COG5489	Protein of unknown function (DUF736)
CO731_RS09245	COG1396	sequence-specific DNA binding
CO731_RS09250	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
CO731_RS09280	COG1053	succinate dehydrogenase
CO731_RS09285	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CO731_RS09305	COG0583	DNA-binding transcription factor activity
CO731_RS09310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO731_RS09315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CO731_RS09320	COG0473	3-isopropylmalate dehydrogenase activity
CO731_RS09340	COG0583	DNA-binding transcription factor activity
CO731_RS09360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CO731_RS09375	COG0653	protein targeting
CO731_RS09380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CO731_RS09390	COG1309	transcriptional regulator
CO731_RS09400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CO731_RS09410	COG0494	nUDIX hydrolase
CO731_RS09430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO731_RS09440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CO731_RS09460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CO731_RS09465	COG0527	aspartate kinase activity
CO731_RS09475	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CO731_RS09480	COG2890	protein-(glutamine-N5) methyltransferase activity
CO731_RS09490	COG0542	response to heat
CO731_RS09500	COG1376	ErfK ybiS ycfS ynhG family protein
CO731_RS09505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CO731_RS09510	COG3153	acetyltransferase
CO731_RS09530	COG0477	Major facilitator Superfamily
CO731_RS09540	COG1196	nuclear chromosome segregation
CO731_RS09540	COG0741	lytic transglycosylase activity
CO731_RS09540	COG0739	heme binding
CO731_RS09640	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_RS09650	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CO731_RS09655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CO731_RS09685	COG0831	urea catabolic process
CO731_RS09685	COG0832	Belongs to the urease beta subunit family
CO731_RS09690	COG0804	urea catabolic process
CO731_RS09695	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CO731_RS09700	COG0829	nickel cation binding
CO731_RS09710	COG0830	nickel cation binding
CO731_RS09745	COG1396	sequence-specific DNA binding
CO731_RS09745	COG3800	Transcriptional regulator
CO731_RS09755	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CO731_RS09760	COG3791	Glutathione-dependent formaldehyde-activating
CO731_RS09780	COG1960	acyl-CoA dehydrogenase activity
CO731_RS09790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CO731_RS09805	COG1802	Transcriptional regulator
CO731_RS09810	COG1250	3-hydroxyacyl-CoA dehydrogenase
CO731_RS09815	COG3246	L-lysine catabolic process to acetate
CO731_RS09830	COG0402	S-adenosylhomocysteine deaminase activity
CO731_RS09835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CO731_RS09845	COG0318	PFAM AMP-dependent synthetase and ligase
CO731_RS09850	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS09875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_RS09910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO731_RS09915	COG0673	inositol 2-dehydrogenase activity
CO731_RS09925	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CO731_RS09940	COG1609	Transcriptional regulator
CO731_RS09955	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_RS09960	COG1129	ABC transporter
CO731_RS09965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO731_RS09980	COG0463	Glycosyl transferase, family 2
CO731_RS09985	COG1215	transferase activity, transferring glycosyl groups
CO731_RS10010	COG0205	6-phosphofructokinase activity
CO731_RS10015	COG1376	ErfK ybiS ycfS ynhG family protein
CO731_RS10015	COG1388	LysM domain
CO731_RS10020	COG1280	lysine exporter protein (LysE YggA)
CO731_RS10035	COG1070	Carbohydrate kinase
CO731_RS10045	COG2115	Belongs to the xylose isomerase family
CO731_RS10055	COG1011	Hydrolase
CO731_RS10060	COG4977	sequence-specific DNA binding
CO731_RS10065	COG3246	L-lysine catabolic process to acetate
CO731_RS10070	COG1250	3-hydroxyacyl-CoA dehydrogenase
CO731_RS10075	COG1960	acyl-CoA dehydrogenase activity
CO731_RS10105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS10140	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CO731_RS10145	COG3257	ureidoglycine aminohydrolase activity
CO731_RS10155	COG2351	hydroxyisourate hydrolase activity
CO731_RS10165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CO731_RS10175	COG0783	Belongs to the Dps family
CO731_RS10195	COG0583	DNA-binding transcription factor activity
CO731_RS10205	COG0402	S-adenosylhomocysteine deaminase activity
CO731_RS10210	COG4702	Belongs to the UPF0303 family
CO731_RS10230	COG0174	glutamine synthetase
CO731_RS10235	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CO731_RS10260	COG0523	cobalamin synthesis protein
CO731_RS10270	COG1846	Transcriptional regulator
CO731_RS10280	COG1609	Transcriptional regulator
CO731_RS10285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CO731_RS10290	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CO731_RS10295	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CO731_RS10295	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CO731_RS10325	COG5001	Diguanylate cyclase
CO731_RS10360	COG1280	lysine exporter protein (LysE YggA)
CO731_RS10375	COG2249	NAD(P)H dehydrogenase (quinone) activity
CO731_RS10385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CO731_RS10395	COG2223	nitrite transmembrane transporter activity
CO731_RS10405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_RS10425	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO731_RS10425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_RS10470	COG0531	amino acid
CO731_RS10505	COG3842	ATPase activity
CO731_RS10515	COG0583	DNA-binding transcription factor activity
CO731_RS10520	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CO731_RS10525	COG3842	ATPase activity
CO731_RS10530	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_RS10535	COG1177	transmembrane transport
CO731_RS10540	COG1012	belongs to the aldehyde dehydrogenase family
CO731_RS10555	COG1609	Transcriptional regulator
CO731_RS10570	COG1024	Enoyl-CoA hydratase
CO731_RS10575	COG1012	belongs to the aldehyde dehydrogenase family
CO731_RS10580	COG1653	transport
CO731_RS10590	COG0395	ABC-type sugar transport system, permease component
CO731_RS10595	COG3842	ATPase activity
CO731_RS10605	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS10635	COG2072	flavoprotein involved in K transport
CO731_RS10680	COG0071	Belongs to the small heat shock protein (HSP20) family
CO731_RS10690	COG2267	carboxylic ester hydrolase activity
CO731_RS10700	COG0067	glutamate synthase
CO731_RS10700	COG0069	glutamate synthase activity
CO731_RS10700	COG0070	glutamate synthase
CO731_RS10715	COG2951	lytic endotransglycosylase activity
CO731_RS10720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CO731_RS10725	COG0778	Nitroreductase
CO731_RS10730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CO731_RS10750	COG0330	HflC and HflK could
CO731_RS10760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CO731_RS10765	COG0737	Belongs to the 5'-nucleotidase family
CO731_RS10775	COG5310	Homospermidine synthase
CO731_RS10800	COG2204	response regulator
CO731_RS10805	COG3108	Peptidase M15
CO731_RS10810	COG0800	Aldolase
CO731_RS10815	COG5632	N-Acetylmuramoyl-L-alanine amidase
CO731_RS10815	COG3409	Peptidoglycan-binding domain 1 protein
CO731_RS10820	COG1054	Belongs to the UPF0176 family
CO731_RS10830	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS10865	COG0583	DNA-binding transcription factor activity
CO731_RS10875	COG0154	amidase activity
CO731_RS10920	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CO731_RS10925	COG2020	methyltransferase activity
CO731_RS10940	COG2814	Major facilitator Superfamily
CO731_RS10950	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CO731_RS10955	COG5443	negative regulation of bacterial-type flagellum assembly
CO731_RS10960	COG5442	Flagellar protein FlaF
CO731_RS11015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CO731_RS11020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CO731_RS11030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CO731_RS11035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CO731_RS11040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CO731_RS11045	COG1338	Plays a role in the flagellum-specific transport system
CO731_RS11055	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CO731_RS11065	COG1706	bacterial-type flagellum-dependent cell motility
CO731_RS11070	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CO731_RS11075	COG4786	Flagellar basal body rod
CO731_RS11080	COG1677	Flagellar hook-basal body complex protein FliE
CO731_RS11085	COG1558	bacterial-type flagellum-dependent cell motility
CO731_RS11090	COG1815	bacterial-type flagellum-dependent cell motility
CO731_RS11100	COG1157	protein secretion by the type III secretion system
CO731_RS11105	COG4786	Flagellar basal body rod
CO731_RS11115	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CO731_RS11120	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CO731_RS11125	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CO731_RS11130	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CO731_RS11135	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CO731_RS11150	COG2771	luxR family
CO731_RS11165	COG1309	transcriptional regulator
CO731_RS11170	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CO731_RS11175	COG3842	ATPase activity
CO731_RS11185	COG1177	transmembrane transport
CO731_RS11230	COG1609	Transcriptional regulator
CO731_RS11235	COG1216	Glycosyl transferase, family 2
CO731_RS11235	COG0463	Glycosyl transferase, family 2
CO731_RS11255	COG1129	ABC transporter
CO731_RS11260	COG4211	Belongs to the binding-protein-dependent transport system permease family
CO731_RS11265	COG0673	inositol 2-dehydrogenase activity
CO731_RS11270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CO731_RS11275	COG3962	Belongs to the TPP enzyme family
CO731_RS11280	COG1082	Xylose isomerase domain protein TIM barrel
CO731_RS11290	COG3718	enzyme involved in inositol metabolism
CO731_RS11295	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CO731_RS11310	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
CO731_RS11330	COG2197	response regulator
CO731_RS11350	COG0747	negative chemotaxis
CO731_RS11375	COG0747	negative chemotaxis
CO731_RS11390	COG3454	Phosphonate metabolism
CO731_RS11395	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CO731_RS11400	COG3639	organic phosphonate transmembrane transporter activity
CO731_RS11415	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CO731_RS11425	COG0786	glutamate:sodium symporter activity
CO731_RS11435	COG4778	phosphonate C-P lyase system protein PhnL
CO731_RS11440	COG4107	phosphonate C-P lyase system protein PhnK
CO731_RS11445	COG3627	carbon phosphorus lyase activity
CO731_RS11455	COG1598	PFAM Uncharacterised protein family UPF0150
CO731_RS11460	COG3626	phosphonate metabolism
CO731_RS11465	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CO731_RS11470	COG3624	Phosphonate C-P lyase system protein PhnG
CO731_RS11475	COG2188	Transcriptional regulator
CO731_RS11480	COG3307	-O-antigen
CO731_RS11485	COG1596	polysaccharide export
CO731_RS11500	COG1215	transferase activity, transferring glycosyl groups
CO731_RS11515	COG2273	Hydrolase Family 16
CO731_RS11545	COG0438	transferase activity, transferring glycosyl groups
CO731_RS11550	COG1215	transferase activity, transferring glycosyl groups
CO731_RS11555	COG1215	transferase activity, transferring glycosyl groups
CO731_RS11560	COG1215	transferase activity, transferring glycosyl groups
CO731_RS11565	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CO731_RS11570	COG3206	protein involved in exopolysaccharide biosynthesis
CO731_RS11570	COG0489	protein tyrosine kinase activity
CO731_RS11595	COG0482	sulfurtransferase activity
CO731_RS11610	COG1733	regulation of RNA biosynthetic process
CO731_RS11625	COG2201	protein-glutamate methylesterase activity
CO731_RS11670	COG0435	Glutathione S-transferase
CO731_RS11675	COG0494	nUDIX hydrolase
CO731_RS11700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CO731_RS11710	COG3180	Ammonia monooxygenase
CO731_RS11735	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CO731_RS11740	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CO731_RS11740	COG0512	Glutamine amidotransferase of anthranilate synthase
CO731_RS11745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO731_RS11755	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CO731_RS11760	COG2814	Major facilitator Superfamily
CO731_RS11765	COG0583	DNA-binding transcription factor activity
CO731_RS11770	COG2962	Rard protein
CO731_RS11775	COG4993	Dehydrogenase
CO731_RS11790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO731_RS11805	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CO731_RS11825	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CO731_RS11860	COG1435	thymidine kinase activity
CO731_RS11870	COG4176	ABC-type proline glycine betaine transport system permease component
CO731_RS11875	COG3448	diguanylate cyclase activity
CO731_RS11875	COG4175	Glycine betaine
CO731_RS11895	COG5507	3-demethylubiquinone-9 3-methyltransferase
CO731_RS11900	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CO731_RS11920	COG1278	Cold shock
CO731_RS11940	COG0714	Associated with various cellular activities
CO731_RS11955	COG0617	tRNA 3'-terminal CCA addition
CO731_RS11970	COG0513	Belongs to the DEAD box helicase family
CO731_RS11985	COG0408	coproporphyrinogen oxidase activity
CO731_RS12005	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CO731_RS12015	COG1132	(ABC) transporter
CO731_RS12020	COG1132	(ABC) transporter
CO731_RS12025	COG1132	(ABC) transporter
CO731_RS12045	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CO731_RS12045	COG2857	Cytochrome c1
CO731_RS12050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO731_RS12075	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CO731_RS12085	COG0012	GTP binding
CO731_RS12090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CO731_RS12100	COG0193	aminoacyl-tRNA hydrolase activity
CO731_RS12105	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CO731_RS12125	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CO731_RS12140	COG1496	oxidoreductase activity
CO731_RS12150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CO731_RS12165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO731_RS12175	COG1464	Belongs to the NlpA lipoprotein family
CO731_RS12180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO731_RS12185	COG2011	ABC-type metal ion transport system permease component
CO731_RS12190	COG2205	protein histidine kinase activity
CO731_RS12200	COG0745	RESPONSE REGULATOR receiver
CO731_RS12205	COG1846	Transcriptional regulator
CO731_RS12210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CO731_RS12220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CO731_RS12230	COG1278	Cold shock
CO731_RS12240	COG1278	Cold shock
CO731_RS12255	COG3791	Glutathione-dependent formaldehyde-activating
CO731_RS12265	COG2264	protein methyltransferase activity
CO731_RS12270	COG1396	sequence-specific DNA binding
CO731_RS12310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CO731_RS12320	COG1522	sequence-specific DNA binding
CO731_RS12345	COG0556	nucleotide-excision repair
CO731_RS12410	COG4948	Mandelate Racemase Muconate Lactonizing
CO731_RS12435	COG1253	flavin adenine dinucleotide binding
CO731_RS12475	COG2133	pyrroloquinoline quinone binding
CO731_RS12480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO731_RS12490	COG1215	transferase activity, transferring glycosyl groups
CO731_RS12505	COG1522	sequence-specific DNA binding
CO731_RS12510	COG0492	ferredoxin-NADP+ reductase activity
CO731_RS12515	COG0583	DNA-binding transcription factor activity
CO731_RS12530	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CO731_RS12535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CO731_RS12550	COG0436	Aminotransferase
CO731_RS12555	COG5001	Diguanylate cyclase
CO731_RS12555	COG3300	MHYT domain
CO731_RS12565	COG0625	glutathione transferase activity
CO731_RS12570	COG1278	Cold shock
CO731_RS12580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CO731_RS12590	COG0456	acetyltransferase
CO731_RS12620	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CO731_RS12620	COG0456	acetyltransferase
CO731_RS12630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CO731_RS12635	COG0640	Transcriptional regulator
CO731_RS12640	COG2814	Major facilitator Superfamily
CO731_RS12650	COG0318	PFAM AMP-dependent synthetase and ligase
CO731_RS12670	COG2321	neutral zinc metallopeptidase
CO731_RS12675	COG4989	oxidoreductase activity
CO731_RS12685	COG0505	Belongs to the CarA family
CO731_RS12700	COG1473	amidohydrolase
CO731_RS12715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CO731_RS12730	COG1280	lysine exporter protein (LysE YggA)
CO731_RS12750	COG1309	transcriptional regulator
CO731_RS12785	COG3685	Protein conserved in bacteria
CO731_RS12800	COG2862	Uncharacterized protein family, UPF0114
CO731_RS12810	COG2983	Belongs to the UPF0260 family
CO731_RS12820	COG2968	Membrane
CO731_RS12840	COG1177	transmembrane transport
CO731_RS12845	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_RS12850	COG3842	ATPase activity
CO731_RS12875	COG2207	Transcriptional regulator
CO731_RS12885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO731_RS12890	COG3474	cytochrome
CO731_RS12935	COG0651	ATP synthesis coupled electron transport
CO731_RS12940	COG1006	Multisubunit Na H antiporter MnhC subunit
CO731_RS12945	COG2111	Na H antiporter
CO731_RS12945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CO731_RS12960	COG2212	antiporter activity
CO731_RS12965	COG1863	multisubunit Na H antiporter MnhE subunit
CO731_RS12985	COG2235	arginine
CO731_RS13025	COG2814	Major facilitator Superfamily
CO731_RS13035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO731_RS13045	COG0583	DNA-binding transcription factor activity
CO731_RS13055	COG1917	Cupin 2, conserved barrel domain protein
CO731_RS13075	COG1129	ABC transporter
CO731_RS13085	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CO731_RS13095	COG2124	cytochrome p450
CO731_RS13115	COG0179	Fumarylacetoacetate (FAA) hydrolase
CO731_RS13120	COG1082	Xylose isomerase domain protein TIM barrel
CO731_RS13125	COG2721	sulfolactate sulfo-lyase activity
CO731_RS13130	COG2721	sulfolactate sulfo-lyase activity
CO731_RS13140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS13145	COG0601	transmembrane transport
CO731_RS13150	COG0747	negative chemotaxis
CO731_RS13155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO731_RS13165	COG0626	cystathionine gamma-synthase activity
CO731_RS13170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_RS13175	COG4597	amino acid ABC transporter
CO731_RS13180	COG0765	amino acid transport
CO731_RS13185	COG1126	abc transporter atp-binding protein
CO731_RS13200	COG0583	DNA-binding transcription factor activity
CO731_RS13205	COG2814	Major facilitator Superfamily
CO731_RS13215	COG0590	tRNA wobble adenosine to inosine editing
CO731_RS13240	COG0601	transmembrane transport
CO731_RS13255	COG4948	Mandelate Racemase Muconate Lactonizing
CO731_RS13270	COG1012	belongs to the aldehyde dehydrogenase family
CO731_RS13275	COG3284	Transcriptional regulator
CO731_RS13290	COG3284	Transcriptional regulator
CO731_RS13300	COG4459	periplasmic nitrate reductase
CO731_RS13325	COG3005	denitrification pathway
CO731_RS13335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO731_RS13365	COG1845	cytochrome c oxidase, subunit III
CO731_RS13380	COG3256	nitric oxide reductase
CO731_RS13385	COG0714	Associated with various cellular activities
CO731_RS13395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CO731_RS13415	COG3707	response regulator
CO731_RS13420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CO731_RS13430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CO731_RS13440	COG0243	molybdopterin cofactor binding
CO731_RS13455	COG0463	Glycosyl transferase, family 2
CO731_RS13495	COG2197	response regulator
CO731_RS13500	COG1280	lysine exporter protein (LysE YggA)
CO731_RS13515	COG0583	DNA-binding transcription factor activity
CO731_RS13525	COG1902	pentaerythritol trinitrate reductase activity
CO731_RS13540	COG0673	inositol 2-dehydrogenase activity
CO731_RS13545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_RS13550	COG4597	amino acid ABC transporter
CO731_RS13555	COG0765	amino acid transport
CO731_RS13580	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CO731_RS13585	COG4208	sulfate ABC transporter
CO731_RS13590	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CO731_RS13595	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CO731_RS13605	COG4953	penicillin-binding protein 1C
CO731_RS13615	COG0729	surface antigen
CO731_RS13625	COG0747	negative chemotaxis
CO731_RS13630	COG0601	transmembrane transport
CO731_RS13635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS13650	COG0493	'glutamate synthase
CO731_RS13670	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CO731_RS13680	COG1309	transcriptional regulator
CO731_RS13685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CO731_RS13705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_RS13710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_RS13740	COG0028	Belongs to the TPP enzyme family
CO731_RS13750	COG2267	carboxylic ester hydrolase activity
CO731_RS13755	COG1131	(ABC) transporter
CO731_RS13760	COG0842	Transport permease protein
CO731_RS13815	COG1720	tRNA m6t6A37 methyltransferase activity
CO731_RS13840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CO731_RS13875	COG0697	spore germination
CO731_RS13880	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CO731_RS13905	COG0626	cystathionine gamma-synthase activity
CO731_RS13910	COG2001	Belongs to the MraZ family
CO731_RS13915	COG0275	rRNA processing
CO731_RS13930	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CO731_RS13940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CO731_RS13945	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CO731_RS13955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CO731_RS13960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CO731_RS13965	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CO731_RS13970	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO731_RS13975	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CO731_RS13980	COG0849	cell division
CO731_RS13985	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CO731_RS13995	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CO731_RS14010	COG2176	DNA-directed DNA polymerase activity
CO731_RS14025	COG0006	proline dipeptidase activity
CO731_RS14025	COG0006	proline dipeptidase activity
CO731_RS14030	COG2264	protein methyltransferase activity
CO731_RS14035	COG1999	signal sequence binding
CO731_RS14070	COG0210	DNA helicase
CO731_RS14095	COG0277	FAD linked oxidase domain protein
CO731_RS14140	COG2814	Major facilitator Superfamily
CO731_RS14175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CO731_RS14200	COG0330	HflC and HflK could
CO731_RS14205	COG0330	HflC and HflK could
CO731_RS14215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CO731_RS14235	COG3830	Belongs to the UPF0237 family
CO731_RS14235	COG0560	Phosphoserine phosphatase
CO731_RS14240	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CO731_RS14270	COG0028	Belongs to the TPP enzyme family
CO731_RS14315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CO731_RS14330	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CO731_RS14335	COG3158	transport of potassium into the cell
CO731_RS14350	COG1309	transcriptional regulator
CO731_RS14355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CO731_RS14385	COG0577	efflux transmembrane transporter activity
CO731_RS14385	COG1136	(ABC) transporter
CO731_RS14390	COG1136	(ABC) transporter
CO731_RS14390	COG0577	efflux transmembrane transporter activity
CO731_RS14400	COG0384	phenazine biosynthesis protein PhzF
CO731_RS14410	COG2066	Belongs to the glutaminase family
CO731_RS14415	COG0628	permease
CO731_RS14430	COG1959	2 iron, 2 sulfur cluster binding
CO731_RS14435	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CO731_RS14440	COG4208	sulfate ABC transporter
CO731_RS14450	COG4150	thiosulfate binding
CO731_RS14455	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CO731_RS14460	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CO731_RS14465	COG1797	cobyrinic acid a,c-diamide synthase activity
CO731_RS14475	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CO731_RS14535	COG3214	Protein conserved in bacteria
CO731_RS14540	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CO731_RS14545	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CO731_RS14550	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CO731_RS14555	COG0649	NAD binding
CO731_RS14560	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CO731_RS14565	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CO731_RS14570	COG3743	rRNA binding
CO731_RS14570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CO731_RS14580	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CO731_RS14585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CO731_RS14595	COG0713	ATP synthesis coupled electron transport
CO731_RS14610	COG1007	ATP synthesis coupled electron transport
CO731_RS14625	COG0346	lactoylglutathione lyase activity
CO731_RS14635	COG0442	prolyl-tRNA aminoacylation
CO731_RS14645	COG1136	(ABC) transporter
CO731_RS14650	COG0321	lipoyl(octanoyl) transferase activity
CO731_RS14675	COG0789	Transcriptional regulator
CO731_RS14680	COG2239	Acts as a magnesium transporter
CO731_RS14705	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CO731_RS14730	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CO731_RS14760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO731_RS14795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_RS14795	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO731_RS14805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_RS14810	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CO731_RS14810	COG3264	Mechanosensitive ion channel
CO731_RS14835	COG1088	dTDP-glucose 4,6-dehydratase activity
CO731_RS14875	COG0583	DNA-binding transcription factor activity
CO731_RS14900	COG0646	methionine synthase
CO731_RS14900	COG1410	methionine synthase
CO731_RS14920	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CO731_RS14925	COG3932	Exopolysaccharide synthesis, ExoD
CO731_RS14945	COG5012	cobalamin binding
CO731_RS14950	COG5598	trimethylamine methyltransferase
CO731_RS14960	COG2186	Transcriptional regulator
CO731_RS14965	COG2807	transmembrane transport
CO731_RS14970	COG2081	HI0933 family
CO731_RS14980	COG2304	oxidoreductase activity
CO731_RS15000	COG1410	methionine synthase
CO731_RS15000	COG0646	methionine synthase
CO731_RS15005	COG3665	Urea carboxylase-associated protein
CO731_RS15025	COG0006	proline dipeptidase activity
CO731_RS15040	COG0251	oxidation-reduction process
CO731_RS15045	COG5598	trimethylamine methyltransferase
CO731_RS15085	COG1960	acyl-CoA dehydrogenase activity
CO731_RS15090	COG1492	cobalamin metabolic process
CO731_RS15120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS15125	COG0601	transmembrane transport
CO731_RS15130	COG0747	negative chemotaxis
CO731_RS15135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO731_RS15165	COG0243	molybdopterin cofactor binding
CO731_RS15170	COG0437	4 iron, 4 sulfur cluster binding
CO731_RS15180	COG1560	Kdo2-lipid A biosynthetic process
CO731_RS15190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CO731_RS15195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CO731_RS15200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO731_RS15225	COG1858	cytochrome C peroxidase
CO731_RS15230	COG1522	sequence-specific DNA binding
CO731_RS15270	COG3720	iron ion transport
CO731_RS15275	COG4558	Periplasmic binding protein
CO731_RS15280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO731_RS15285	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CO731_RS15290	COG2514	catechol 2,3-dioxygenase activity
CO731_RS15295	COG0037	tRNA processing
CO731_RS15300	COG2814	Major facilitator Superfamily
CO731_RS15305	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CO731_RS15315	COG2226	methyltransferase
CO731_RS15325	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CO731_RS15340	COG0047	phosphoribosylformylglycinamidine synthase activity
CO731_RS15350	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CO731_RS15355	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CO731_RS15375	COG1959	2 iron, 2 sulfur cluster binding
CO731_RS15385	COG2733	membrane
CO731_RS15440	COG2832	Protein of unknown function (DUF454)
CO731_RS15475	COG2948	multi-organism process
CO731_RS15490	COG3846	protein secretion by the type IV secretion system
CO731_RS15505	COG3451	type IV secretory pathway VirB4
CO731_RS15520	COG4962	Type ii secretion system protein e
CO731_RS15550	COG3436	PFAM IS66 Orf2 family protein
CO731_RS15555	COG2433	Pfam Transposase IS66
CO731_RS15560	COG0741	lytic transglycosylase activity
CO731_RS15595	COG3608	succinylglutamate desuccinylase aspartoacylase
CO731_RS15600	COG1126	abc transporter atp-binding protein
CO731_RS15605	COG4597	amino acid ABC transporter
CO731_RS15610	COG0765	amino acid transport
CO731_RS15615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_RS15635	COG2197	response regulator
CO731_RS15640	COG3916	Acyl-homoserine-lactone synthase
CO731_RS15645	COG5489	Protein of unknown function (DUF736)
CO731_RS15680	COG1733	regulation of RNA biosynthetic process
CO731_RS15695	COG0583	DNA-binding transcription factor activity
CO731_RS15705	COG0456	acetyltransferase
CO731_RS15715	COG3852	Histidine kinase
CO731_RS15765	COG0573	inorganic phosphate transmembrane transporter activity
CO731_RS15770	COG0581	inorganic phosphate transmembrane transporter activity
CO731_RS15775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CO731_RS15780	COG0704	Plays a role in the regulation of phosphate uptake
CO731_RS15785	COG0745	RESPONSE REGULATOR receiver
CO731_RS15805	COG0431	NADPH-dependent FMN reductase
CO731_RS15810	COG1393	Belongs to the ArsC family
CO731_RS15815	COG0798	PFAM Bile acid sodium symporter
CO731_RS15830	COG0640	Transcriptional regulator
CO731_RS15845	COG1793	dna ligase
CO731_RS15885	COG2217	Heavy metal translocating P-type atpase
CO731_RS15915	COG1136	(ABC) transporter
CO731_RS15955	COG0071	Belongs to the small heat shock protein (HSP20) family
CO731_RS16010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO731_RS16050	COG0045	succinate-CoA ligase (ADP-forming) activity
CO731_RS16050	COG1042	CoA-binding domain protein
CO731_RS16050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO731_RS16060	COG2217	Heavy metal translocating P-type atpase
CO731_RS16080	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CO731_RS16105	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CO731_RS16120	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CO731_RS16135	COG2205	protein histidine kinase activity
CO731_RS16150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CO731_RS16165	COG2235	arginine
CO731_RS16195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CO731_RS16210	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CO731_RS16215	COG2205	protein histidine kinase activity
CO731_RS16215	COG2202	Pas domain
CO731_RS16230	COG1573	uracil-dna glycosylase
CO731_RS16235	COG1522	sequence-specific DNA binding
CO731_RS16245	COG2084	Dehydrogenase
CO731_RS16270	COG0746	molybdenum cofactor guanylyltransferase activity
CO731_RS16285	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CO731_RS16305	COG1846	Transcriptional regulator
CO731_RS16320	COG2989	Protein conserved in bacteria
CO731_RS16335	COG0546	phosphoglycolate phosphatase activity
CO731_RS16340	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CO731_RS16355	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CO731_RS16370	COG2199	diguanylate cyclase activity
CO731_RS16380	COG3384	dioxygenase
CO731_RS16385	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CO731_RS16425	COG0740	serine-type endopeptidase activity
CO731_RS16435	COG0640	Transcriptional regulator
CO731_RS16440	COG1132	(ABC) transporter
CO731_RS16445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CO731_RS16455	COG0280	phosphate acetyltransferase
CO731_RS16455	COG0281	malic enzyme
CO731_RS16475	COG4948	Mandelate Racemase Muconate Lactonizing
CO731_RS16480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CO731_RS16485	COG1127	ABC transporter
CO731_RS16495	COG3218	ABC-type transport auxiliary lipoprotein component
CO731_RS16495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CO731_RS16510	COG0633	Ferredoxin
CO731_RS16515	COG0492	ferredoxin-NADP+ reductase activity
CO731_RS16525	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CO731_RS16535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CO731_RS16550	COG0784	Response regulator, receiver
CO731_RS16570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO731_RS16575	COG2814	Major facilitator Superfamily
CO731_RS16590	COG0557	exoribonuclease II activity
CO731_RS16595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CO731_RS16605	COG0758	DNA mediated transformation
CO731_RS16610	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CO731_RS16615	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CO731_RS16620	COG0540	Belongs to the ATCase OTCase family
CO731_RS16625	COG1960	acyl-CoA dehydrogenase activity
CO731_RS16635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CO731_RS16640	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CO731_RS16650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO731_RS16655	COG0154	amidase activity
CO731_RS16665	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CO731_RS16675	COG1760	l-serine dehydratase
CO731_RS16690	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CO731_RS16705	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CO731_RS16715	COG3706	GGDEF domain
CO731_RS16740	COG0537	adenosine 5'-monophosphoramidase activity
CO731_RS16755	COG0584	glycerophosphoryl diester phosphodiesterase
CO731_RS16775	COG0052	Belongs to the universal ribosomal protein uS2 family
CO731_RS16780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CO731_RS16785	COG0528	UMP kinase activity
CO731_RS16790	COG0233	cytoplasmic translational termination
CO731_RS16795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CO731_RS16805	COG0750	zinc metalloprotease
CO731_RS16810	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CO731_RS16815	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CO731_RS16820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CO731_RS16825	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CO731_RS16830	COG3494	Protein of unknown function (DUF1009)
CO731_RS16835	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CO731_RS16840	COG0372	Belongs to the citrate synthase family
CO731_RS16845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CO731_RS16855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CO731_RS16860	COG0303	'Molybdopterin
CO731_RS16865	COG0315	cyclic pyranopterin monophosphate synthase activity
CO731_RS16870	COG0134	indole-3-glycerol-phosphate synthase activity
CO731_RS16875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CO731_RS16885	COG0149	triose-phosphate isomerase activity
CO731_RS16900	COG0504	CTP synthase activity
CO731_RS16915	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CO731_RS16930	COG0148	phosphopyruvate hydratase activity
CO731_RS16935	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CO731_RS16940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CO731_RS16945	COG0022	dehydrogenase e1 component
CO731_RS16945	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO731_RS16950	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO731_RS16960	COG0456	acetyltransferase
CO731_RS16965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO731_RS16975	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CO731_RS16980	COG2867	negative regulation of translational initiation
CO731_RS16990	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CO731_RS16990	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CO731_RS17000	COG3852	Histidine kinase
CO731_RS17005	COG2204	response regulator
CO731_RS17010	COG5000	phosphorelay sensor kinase activity
CO731_RS17015	COG2204	response regulator
CO731_RS17020	COG0569	domain protein
CO731_RS17025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CO731_RS17030	COG1923	regulation of RNA biosynthetic process
CO731_RS17035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CO731_RS17040	COG3956	TIGRFAM MazG family protein
CO731_RS17045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CO731_RS17055	COG0546	phosphoglycolate phosphatase activity
CO731_RS17065	COG0174	glutamine synthetase
CO731_RS17075	COG0346	lactoylglutathione lyase activity
CO731_RS17090	COG0174	glutamine synthetase
CO731_RS17095	COG0347	Belongs to the P(II) protein family
CO731_RS17100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CO731_RS17100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CO731_RS17115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CO731_RS17125	COG1794	racemase activity, acting on amino acids and derivatives
CO731_RS17140	COG0671	phosphoesterase, PA-phosphatase related
CO731_RS17145	COG0629	single-stranded DNA binding
CO731_RS17160	COG2095	MarC family integral membrane protein
CO731_RS17165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CO731_RS17170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CO731_RS17190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CO731_RS17195	COG0343	queuine tRNA-ribosyltransferase activity
CO731_RS17230	COG2308	Evidence 4 Homologs of previously reported genes of
CO731_RS17290	COG0785	Cytochrome C biogenesis protein
CO731_RS17295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CO731_RS17300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CO731_RS17310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CO731_RS17320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CO731_RS17335	COG4166	transmembrane transport
CO731_RS17350	COG0679	Auxin Efflux Carrier
CO731_RS17355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CO731_RS17360	COG1183	phosphatidylcholine synthase activity
CO731_RS17370	COG3845	ABC transporter
CO731_RS17375	COG4603	Belongs to the binding-protein-dependent transport system permease family
CO731_RS17380	COG1079	Belongs to the binding-protein-dependent transport system permease family
CO731_RS17390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CO731_RS17395	COG0861	Integral membrane protein TerC family
CO731_RS17410	COG0739	heme binding
CO731_RS17580	COG2814	Major facilitator Superfamily
CO731_RS17605	COG1686	Belongs to the peptidase S11 family
CO731_RS17610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CO731_RS17625	COG0084	hydrolase, TatD family'
CO731_RS17630	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CO731_RS17630	COG0321	lipoyl(octanoyl) transferase activity
CO731_RS17640	COG2826	transposase and inactivated derivatives, IS30 family
CO731_RS17645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CO731_RS17650	COG4638	Rieske (2fe-2S)
CO731_RS17655	COG0583	DNA-binding transcription factor activity
CO731_RS17660	COG0747	negative chemotaxis
CO731_RS17675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS17680	COG0601	transmembrane transport
CO731_RS17685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_RS17705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_RS17705	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO731_RS17710	COG4311	Sarcosine oxidase, delta subunit
CO731_RS17715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_RS17740	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CO731_RS17745	COG0667	Aldo Keto reductase
CO731_RS17755	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_RS17790	COG3453	Protein conserved in bacteria
CO731_RS17790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CO731_RS17795	COG3453	Protein conserved in bacteria
CO731_RS17795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CO731_RS17800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CO731_RS17810	COG0203	ribosomal protein L17
CO731_RS17815	COG0202	RNA polymerase activity
CO731_RS17820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CO731_RS17825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CO731_RS17830	COG0563	adenylate kinase activity
CO731_RS17840	COG0200	Binds to the 23S rRNA
CO731_RS17845	COG1841	ribosomal large subunit assembly
CO731_RS17850	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CO731_RS17855	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CO731_RS17860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CO731_RS17865	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CO731_RS17870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CO731_RS17875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CO731_RS17880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CO731_RS17885	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CO731_RS17890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CO731_RS17895	COG0255	Belongs to the universal ribosomal protein uL29 family
CO731_RS17900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CO731_RS17905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CO731_RS17910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CO731_RS17915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CO731_RS17920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CO731_RS17925	COG0089	rRNA binding
CO731_RS17930	COG0088	Forms part of the polypeptide exit tunnel
CO731_RS17935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CO731_RS17940	COG0051	transcription antitermination factor activity, RNA binding
CO731_RS17945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CO731_RS17950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CO731_RS17955	COG0049	tRNA binding
CO731_RS17960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CO731_RS17970	COG0531	amino acid
CO731_RS17975	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CO731_RS17980	COG0085	RNA polymerase activity
CO731_RS17985	COG0222	ribosome binding
CO731_RS17990	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CO731_RS17995	COG0081	regulation of translation
CO731_RS18000	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CO731_RS18010	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CO731_RS18030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CO731_RS18045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO731_RS18055	COG2084	Dehydrogenase
CO731_RS18060	COG3622	Belongs to the hyi family
CO731_RS18065	COG3960	tartronate-semialdehyde synthase activity
CO731_RS18070	COG1414	Transcriptional regulator
CO731_RS18080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CO731_RS18090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CO731_RS18095	COG0513	Belongs to the DEAD box helicase family
CO731_RS18100	COG2885	chlorophyll binding
CO731_RS18125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CO731_RS18130	COG0860	N-Acetylmuramoyl-L-alanine amidase
CO731_RS18135	COG1530	ribonuclease E activity
CO731_RS18140	COG4957	zinc ion binding
CO731_RS18150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CO731_RS18160	COG0737	Belongs to the 5'-nucleotidase family
CO731_RS18165	COG1522	sequence-specific DNA binding
CO731_RS18170	COG0686	Belongs to the AlaDH PNT family
CO731_RS18175	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CO731_RS18175	COG2885	chlorophyll binding
CO731_RS18195	COG2897	thiosulfate sulfurtransferase activity
CO731_RS18200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CO731_RS18205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CO731_RS18210	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS18220	COG0513	Belongs to the DEAD box helicase family
CO731_RS18250	COG3106	COG3106 Predicted ATPase
CO731_RS18255	COG3768	UPF0283 membrane protein
CO731_RS18270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CO731_RS18270	COG0475	glutathione-regulated potassium exporter activity
CO731_RS18285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO731_RS18295	COG1376	ErfK ybiS ycfS ynhG family protein
CO731_RS18315	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CO731_RS18325	COG1671	Belongs to the UPF0178 family
CO731_RS18340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CO731_RS18345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_RS18350	COG0509	glycine decarboxylation via glycine cleavage system
CO731_RS18355	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CO731_RS18355	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CO731_RS18365	COG0187	DNA topoisomerase II activity
CO731_RS18380	COG2301	Belongs to the HpcH HpaI aldolase family
CO731_RS18385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CO731_RS18390	COG0778	Nitroreductase
CO731_RS18400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CO731_RS18410	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CO731_RS18415	COG0583	DNA-binding transcription factor activity
CO731_RS18425	COG0302	gtp cyclohydrolase
CO731_RS18430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CO731_RS18435	COG1752	Esterase of the alpha-beta hydrolase superfamily
CO731_RS18440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CO731_RS18445	COG1494	fructose-1,6-bisphosphatase
CO731_RS18455	COG0436	Aminotransferase
CO731_RS18465	COG3243	poly(R)-hydroxyalkanoic acid synthase
CO731_RS18525	COG1802	Transcriptional regulator
CO731_RS18540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CO731_RS18550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_RS18555	COG1802	Transcriptional regulator
CO731_RS18560	COG2824	Alkylphosphonate utilization operon protein PhnA
CO731_RS18570	COG0024	Methionine aminopeptidase
CO731_RS18575	COG2003	Belongs to the UPF0758 family
CO731_RS18635	COG2197	response regulator
CO731_RS18655	COG3846	protein secretion by the type IV secretion system
CO731_RS18670	COG2948	multi-organism process
CO731_RS18690	COG0544	peptidyl-prolyl cis-trans isomerase activity
CO731_RS18700	COG0438	transferase activity, transferring glycosyl groups
CO731_RS18730	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CO731_RS18735	COG0519	Catalyzes the synthesis of GMP from XMP
CO731_RS18755	COG1862	Preprotein translocase
CO731_RS18770	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CO731_RS18775	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CO731_RS18780	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CO731_RS18785	COG0805	protein transport
CO731_RS18790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CO731_RS18795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CO731_RS18805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CO731_RS18810	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CO731_RS18825	COG0018	arginyl-trna synthetase
CO731_RS18830	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CO731_RS18850	COG2233	PERMEase
CO731_RS18870	COG0525	valine-tRNA ligase activity
CO731_RS18885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CO731_RS18905	COG1473	amidohydrolase
CO731_RS18930	COG0436	Aminotransferase
CO731_RS18945	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CO731_RS18950	COG0511	ligase activity, forming carbon-carbon bonds
CO731_RS18960	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CO731_RS18985	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CO731_RS18990	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CO731_RS19000	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO731_RS19005	COG3811	Belongs to the UPF0386 family
CO731_RS19010	COG0516	GMP reductase activity
CO731_RS19010	COG0517	IMP dehydrogenase activity
CO731_RS19055	COG1024	Enoyl-CoA hydratase
CO731_RS19075	COG1278	Cold shock
CO731_RS19080	COG0346	lactoylglutathione lyase activity
CO731_RS19090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CO731_RS19095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CO731_RS19110	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CO731_RS19175	COG1058	Belongs to the CinA family
CO731_RS19175	COG1546	Belongs to the CinA family
CO731_RS19185	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CO731_RS19195	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CO731_RS19200	COG2827	Endonuclease containing a URI domain
CO731_RS19205	COG2827	Endonuclease containing a URI domain
CO731_RS19210	COG1607	acyl-coa hydrolase
CO731_RS19220	COG2855	membrane
CO731_RS19225	COG0583	DNA-binding transcription factor activity
CO731_RS19250	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO731_RS19250	COG0596	Alpha beta hydrolase
CO731_RS19285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CO731_RS19290	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CO731_RS19290	COG3608	succinylglutamate desuccinylase aspartoacylase
CO731_RS19310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CO731_RS19320	COG3191	aminopeptidase activity
CO731_RS19335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CO731_RS19340	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CO731_RS19350	COG1733	regulation of RNA biosynthetic process
CO731_RS19365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CO731_RS19375	COG0538	isocitrate dehydrogenase activity
CO731_RS19385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CO731_RS19390	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CO731_RS19395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CO731_RS19400	COG2313	pseudouridylate synthase activity
CO731_RS19415	COG0316	Belongs to the HesB IscA family
CO731_RS19420	COG2151	metal-sulfur cluster biosynthetic enzyme
CO731_RS19425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CO731_RS19430	COG0719	Fe-S assembly protein
CO731_RS19435	COG0396	ATPase activity
CO731_RS19440	COG0719	Fe-S assembly protein
CO731_RS19445	COG1104	cysteine desulfurase activity
CO731_RS19450	COG2945	thiolester hydrolase activity
CO731_RS19470	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CO731_RS19475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CO731_RS19485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CO731_RS19490	COG0739	heme binding
CO731_RS19505	COG0720	synthase
CO731_RS19515	COG5001	Diguanylate cyclase
CO731_RS19535	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CO731_RS19550	COG0156	8-amino-7-oxononanoate synthase activity
CO731_RS19560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CO731_RS19565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CO731_RS19585	COG4608	Belongs to the ABC transporter superfamily
CO731_RS19590	COG0444	Belongs to the ABC transporter superfamily
CO731_RS19595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS19600	COG0601	transmembrane transport
CO731_RS19605	COG1396	sequence-specific DNA binding
CO731_RS19610	COG0747	negative chemotaxis
CO731_RS19625	COG0776	regulation of translation
CO731_RS19635	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CO731_RS19640	COG0740	serine-type endopeptidase activity
CO731_RS19685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CO731_RS19690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CO731_RS19700	COG0584	glycerophosphoryl diester phosphodiesterase
CO731_RS19705	COG0010	Belongs to the arginase family
CO731_RS19720	COG1612	heme a metabolic process
CO731_RS19750	COG0438	transferase activity, transferring glycosyl groups
CO731_RS19755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CO731_RS19795	COG0776	regulation of translation
CO731_RS19800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CO731_RS19805	COG0416	fatty acid biosynthetic process
CO731_RS19820	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CO731_RS19825	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CO731_RS19840	COG1174	glycine betaine transport
CO731_RS19845	COG1125	glycine betaine transport
CO731_RS19850	COG1174	glycine betaine transport
CO731_RS19855	COG1732	Glycine betaine
CO731_RS19860	COG2814	Major facilitator Superfamily
CO731_RS19865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CO731_RS19880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CO731_RS19880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CO731_RS19885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CO731_RS19890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CO731_RS19895	COG2989	Protein conserved in bacteria
CO731_RS19910	COG1024	Enoyl-CoA hydratase
CO731_RS19915	COG0113	porphobilinogen synthase activity
CO731_RS19925	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CO731_RS19935	COG0628	permease
CO731_RS19940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CO731_RS19950	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CO731_RS19965	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CO731_RS19995	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CO731_RS20025	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CO731_RS20055	COG3842	ATPase activity
CO731_RS20065	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_RS20085	COG1079	Belongs to the binding-protein-dependent transport system permease family
CO731_RS20095	COG3845	ABC transporter
CO731_RS20105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CO731_RS20135	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CO731_RS20145	COG1079	Belongs to the binding-protein-dependent transport system permease family
CO731_RS20150	COG4603	Belongs to the binding-protein-dependent transport system permease family
CO731_RS20155	COG3845	ABC transporter
CO731_RS20160	COG1744	ABC transporter substrate-binding protein PnrA-like
CO731_RS20170	COG2169	Transcriptional regulator
CO731_RS20175	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CO731_RS20185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO731_RS20200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_RS20210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CO731_RS20210	COG2111	Na H antiporter
CO731_RS20215	COG1006	Multisubunit Na H antiporter MnhC subunit
CO731_RS20220	COG0651	ATP synthesis coupled electron transport
CO731_RS20225	COG1863	multisubunit Na H antiporter MnhE subunit
CO731_RS20230	COG2212	antiporter activity
CO731_RS20235	COG1320	monovalent cation:proton antiporter activity
CO731_RS20245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CO731_RS20250	COG0318	PFAM AMP-dependent synthetase and ligase
CO731_RS20260	COG0367	asparagine synthase
CO731_RS20265	COG2890	protein-(glutamine-N5) methyltransferase activity
CO731_RS20315	COG1846	Transcriptional regulator
CO731_RS20315	COG1940	carbohydrate kinase activity
CO731_RS20350	COG2252	PERMEase
CO731_RS20375	COG3842	ATPase activity
CO731_RS20385	COG0395	ABC-type sugar transport system, permease component
CO731_RS20400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CO731_RS20410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CO731_RS20415	COG1132	(ABC) transporter
CO731_RS20420	COG3459	Glycosyltransferase 36 associated
CO731_RS20435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CO731_RS20445	COG2986	histidine ammonia-lyase
CO731_RS20450	COG1228	amidohydrolase
CO731_RS20465	COG0251	oxidation-reduction process
CO731_RS20470	COG1121	(ABC) transporter
CO731_RS20475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO731_RS20480	COG0803	Belongs to the bacterial solute-binding protein 9 family
CO731_RS20515	COG1234	tRNA 3'-trailer cleavage
CO731_RS20525	COG1063	alcohol dehydrogenase
CO731_RS20540	COG4948	Mandelate Racemase Muconate Lactonizing
CO731_RS20550	COG1960	acyl-CoA dehydrogenase activity
CO731_RS20560	COG1902	pentaerythritol trinitrate reductase activity
CO731_RS20560	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO731_RS20565	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CO731_RS20580	COG5598	trimethylamine methyltransferase
CO731_RS20585	COG0583	DNA-binding transcription factor activity
CO731_RS20590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CO731_RS20600	COG1663	tetraacyldisaccharide 4'-kinase activity
CO731_RS20605	COG1519	Transferase
CO731_RS20620	COG0483	inositol monophosphate 1-phosphatase activity
CO731_RS20625	COG0312	modulator of DNA gyrase
CO731_RS20640	COG0612	Peptidase, M16
CO731_RS20645	COG0612	Peptidase, M16
CO731_RS20655	COG0742	ribosomal rna small subunit methyltransferase
CO731_RS20665	COG0590	tRNA wobble adenosine to inosine editing
CO731_RS20675	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CO731_RS20690	COG0196	riboflavin kinase activity
CO731_RS20705	COG2814	Major facilitator Superfamily
CO731_RS20720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CO731_RS20720	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CO731_RS20730	COG0459	protein refolding
CO731_RS20740	COG3237	CsbD-like
CO731_RS20745	COG0114	fumarate hydratase activity
CO731_RS20750	COG2259	Doxx family
CO731_RS20765	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CO731_RS20775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CO731_RS20785	COG1126	abc transporter atp-binding protein
CO731_RS20790	COG0765	amino acid transport
CO731_RS20795	COG4597	amino acid ABC transporter
CO731_RS20800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_RS20810	COG0626	cystathionine gamma-synthase activity
CO731_RS20850	COG2186	Transcriptional regulator
CO731_RS20855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO731_RS20860	COG0129	dihydroxy-acid dehydratase activity
CO731_RS20865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CO731_RS20870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CO731_RS20875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CO731_RS20880	COG3734	2-keto-3-deoxy-galactonokinase
CO731_RS20885	COG0800	Aldolase
CO731_RS20905	COG0628	permease
CO731_RS20915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CO731_RS20920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CO731_RS20935	COG0243	molybdopterin cofactor binding
CO731_RS20940	COG0488	(ABC) transporter
CO731_RS20960	COG0105	UTP biosynthetic process
CO731_RS20965	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CO731_RS20970	COG0314	molybdopterin synthase activity
CO731_RS20985	COG0322	excinuclease ABC activity
CO731_RS20990	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS21000	COG0625	glutathione transferase activity
CO731_RS21015	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CO731_RS21040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CO731_RS21065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CO731_RS21070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CO731_RS21075	COG0194	GDP metabolic process
CO731_RS21080	COG1561	YicC-like family, N-terminal region
CO731_RS21085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CO731_RS21090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CO731_RS21095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO731_RS21105	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CO731_RS21110	COG1368	sulfuric ester hydrolase activity
CO731_RS21115	COG0360	Binds together with S18 to 16S ribosomal RNA
CO731_RS21125	COG0359	binds to the 23S rRNA
CO731_RS21130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CO731_RS21135	COG1742	UPF0060 membrane protein
CO731_RS21145	COG0305	Participates in initiation and elongation during chromosome replication
CO731_RS21165	COG2814	Major facilitator Superfamily
CO731_RS21170	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CO731_RS21180	COG4221	oxidoreductase activity
CO731_RS21185	COG0471	metal ion transport
CO731_RS21185	COG3273	potassium ion transport
CO731_RS21205	COG0318	PFAM AMP-dependent synthetase and ligase
CO731_RS21205	COG0204	Acyl-transferase
CO731_RS21215	COG0688	phosphatidylethanolamine metabolic process
CO731_RS21230	COG5265	(ABC) transporter
CO731_RS21240	COG1652	LysM domain
CO731_RS21255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CO731_RS21285	COG2852	Protein conserved in bacteria
CO731_RS21295	COG0215	cysteine-tRNA ligase activity
CO731_RS21340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CO731_RS21350	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CO731_RS21375	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CO731_RS21385	COG0640	Transcriptional regulator
CO731_RS21405	COG1595	DNA-templated transcription, initiation
CO731_RS21415	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
CO731_RS21440	COG1381	Involved in DNA repair and RecF pathway recombination
CO731_RS21460	COG2814	Major facilitator Superfamily
CO731_RS21470	COG4221	oxidoreductase activity
CO731_RS21500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CO731_RS21505	COG1418	mRNA catabolic process
CO731_RS21515	COG2195	Cleaves the N-terminal amino acid of tripeptides
CO731_RS21545	COG0300	oxidoreductase activity
CO731_RS21555	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CO731_RS21560	COG0571	ribonuclease III activity
CO731_RS21565	COG0681	Belongs to the peptidase S26 family
CO731_RS21570	COG0736	holo-[acyl-carrier-protein] synthase activity
CO731_RS21575	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CO731_RS21585	COG1758	RNA polymerase activity
CO731_RS21605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CO731_RS21610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO731_RS21615	COG0741	lytic transglycosylase activity
CO731_RS21620	COG2945	thiolester hydrolase activity
CO731_RS21620	COG0596	Alpha beta hydrolase
CO731_RS21655	COG4453	Protein conserved in bacteria
CO731_RS21660	COG5489	Protein of unknown function (DUF736)
CO731_RS21695	COG1192	Involved in chromosome partitioning
CO731_RS21720	COG0741	lytic transglycosylase activity
CO731_RS21735	COG0596	Alpha beta hydrolase
CO731_RS21735	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO731_RS21740	COG0583	DNA-binding transcription factor activity
CO731_RS21755	COG4962	Type ii secretion system protein e
CO731_RS21770	COG3451	type IV secretory pathway VirB4
CO731_RS21785	COG3846	protein secretion by the type IV secretion system
CO731_RS21800	COG2948	multi-organism process
CO731_RS21810	COG0583	DNA-binding transcription factor activity
CO731_RS21825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CO731_RS21845	COG4991	sh3 domain protein
CO731_RS21905	COG4974	Belongs to the 'phage' integrase family
CO731_RS21920	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
CO731_RS21925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CO731_RS21935	COG1960	acyl-CoA dehydrogenase activity
CO731_RS21955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CO731_RS21970	COG0450	alkyl hydroperoxide reductase
CO731_RS21990	COG0625	glutathione transferase activity
CO731_RS22000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CO731_RS22025	COG1573	uracil-dna glycosylase
CO731_RS22050	COG0308	aminopeptidase N
CO731_RS22055	COG2205	protein histidine kinase activity
CO731_RS22055	COG2202	Pas domain
CO731_RS22065	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CO731_RS22070	COG2205	protein histidine kinase activity
CO731_RS22075	COG0745	RESPONSE REGULATOR receiver
CO731_RS22080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CO731_RS22085	COG3088	subunit of a heme lyase
CO731_RS22090	COG1138	Cytochrome C-type biogenesis protein
CO731_RS22095	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CO731_RS22100	COG4235	cytochrome complex assembly
CO731_RS22140	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CO731_RS22175	COG2205	protein histidine kinase activity
CO731_RS22185	COG2166	iron-sulfur cluster assembly
CO731_RS22195	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CO731_RS22205	COG4957	zinc ion binding
CO731_RS22225	COG2010	Cytochrome c
CO731_RS22235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CO731_RS22240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CO731_RS22250	COG1376	ErfK ybiS ycfS ynhG family protein
CO731_RS22255	COG0433	COG0433 Predicted ATPase
CO731_RS22265	COG3654	unkown
CO731_RS22270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO731_RS22280	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS22285	COG0183	Belongs to the thiolase family
CO731_RS22290	COG1309	transcriptional regulator
CO731_RS22295	COG3119	arylsulfatase activity
CO731_RS22305	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CO731_RS22310	COG1012	belongs to the aldehyde dehydrogenase family
CO731_RS22315	COG0662	Cupin 2, conserved barrel domain protein
CO731_RS22315	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CO731_RS22320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO731_RS22450	COG0366	Alpha amylase catalytic
CO731_RS22455	COG1523	belongs to the glycosyl hydrolase 13 family
CO731_RS22460	COG0033	Phosphoglucomutase
CO731_RS22465	COG0297	glycogen (starch) synthase activity
CO731_RS22470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CO731_RS22475	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CO731_RS22480	COG0058	SHG alpha-glucan phosphorylase activity
CO731_RS22500	COG1940	carbohydrate kinase activity
CO731_RS22520	COG1218	3'(2'),5'-bisphosphate nucleotidase
CO731_RS22530	COG0175	sulfate reduction
CO731_RS22560	COG0318	PFAM AMP-dependent synthetase and ligase
CO731_RS22570	COG0574	Belongs to the PEP-utilizing enzyme family
CO731_RS22570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CO731_RS22600	COG0189	ligase activity
CO731_RS22630	COG0829	nickel cation binding
CO731_RS22635	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CO731_RS22640	COG0804	urea catabolic process
CO731_RS22645	COG0832	Belongs to the urease beta subunit family
CO731_RS22645	COG0831	urea catabolic process
CO731_RS22650	COG0830	nickel cation binding
CO731_RS22695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_RS22710	COG0010	Belongs to the arginase family
CO731_RS22745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CO731_RS22750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CO731_RS22760	COG1196	nuclear chromosome segregation
CO731_RS22765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CO731_RS22775	COG1194	a g-specific adenine glycosylase
CO731_RS22780	COG1011	Hydrolase
CO731_RS22785	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CO731_RS22790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO731_RS22805	COG0612	Peptidase, M16
CO731_RS22810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO731_RS22820	COG1678	Uncharacterized ACR, COG1678
CO731_RS22830	COG0678	peroxiredoxin activity
CO731_RS22835	COG0328	RNA-DNA hybrid ribonuclease activity
CO731_RS22840	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CO731_RS22845	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CO731_RS22850	COG3346	SURF1 family
CO731_RS22870	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CO731_RS22875	COG0109	protoheme IX farnesyltransferase activity
CO731_RS22880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CO731_RS22885	COG1565	acr, cog1565
CO731_RS22885	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CO731_RS22905	COG0312	modulator of DNA gyrase
CO731_RS22910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO731_RS22920	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CO731_RS22925	COG1741	Belongs to the pirin family
CO731_RS22935	COG1722	exodeoxyribonuclease VII activity
CO731_RS22940	COG0123	including yeast histone deacetylase and acetoin utilization protein
CO731_RS22945	COG1309	transcriptional regulator
CO731_RS22965	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CO731_RS22965	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CO731_RS22970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CO731_RS22980	COG0406	alpha-ribazole phosphatase activity
CO731_RS22985	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CO731_RS22990	COG0484	heat shock protein binding
CO731_RS23000	COG0259	pyridoxamine-phosphate oxidase activity
CO731_RS23010	COG1960	acyl-CoA dehydrogenase activity
CO731_RS23025	COG0151	Belongs to the GarS family
CO731_RS23030	COG4115	mRNA cleavage
CO731_RS23055	COG0009	L-threonylcarbamoyladenylate synthase
CO731_RS23070	COG0751	glycine-tRNA ligase activity
CO731_RS23075	COG0752	glycyl-tRNA synthetase alpha subunit
CO731_RS23085	COG0142	geranyltranstransferase activity
CO731_RS23110	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CO731_RS23115	COG0521	Mo-molybdopterin cofactor biosynthetic process
CO731_RS23135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CO731_RS23140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CO731_RS23145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CO731_RS23150	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO731_RS23155	COG0356	it plays a direct role in the translocation of protons across the membrane
CO731_RS23170	COG1160	GTP binding
CO731_RS23185	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CO731_RS23190	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CO731_RS23200	COG0583	DNA-binding transcription factor activity
CO731_RS23205	COG1393	Belongs to the ArsC family
CO731_RS23210	COG1846	Transcriptional regulator
CO731_RS23235	COG0640	Transcriptional regulator
CO731_RS23240	COG0402	S-adenosylhomocysteine deaminase activity
CO731_RS23250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CO731_RS23255	COG4608	Belongs to the ABC transporter superfamily
CO731_RS23260	COG0444	Belongs to the ABC transporter superfamily
CO731_RS23265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS23270	COG0601	transmembrane transport
CO731_RS23285	COG0402	S-adenosylhomocysteine deaminase activity
CO731_RS23295	COG0494	nUDIX hydrolase
CO731_RS23300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_RS23305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CO731_RS23320	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CO731_RS23350	COG2176	DNA-directed DNA polymerase activity
CO731_RS23355	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CO731_RS23390	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CO731_RS23395	COG1205	dead DEAH box helicase
CO731_RS23395	COG1111	helicase
CO731_RS23420	COG1475	DNA binding
CO731_RS23450	COG5489	Protein of unknown function (DUF736)
CO731_RS23480	COG1192	Involved in chromosome partitioning
CO731_RS23525	COG4962	Type ii secretion system protein e
CO731_RS23530	COG3838	Conjugal transfer protein Trbc
CO731_RS23540	COG3451	type IV secretory pathway VirB4
CO731_RS23555	COG3846	protein secretion by the type IV secretion system
CO731_RS23570	COG2948	multi-organism process
CO731_RS23580	COG0583	DNA-binding transcription factor activity
CO731_RS23625	COG1968	undecaprenyl-diphosphatase activity
CO731_RS23630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CO731_RS23660	COG0148	phosphopyruvate hydratase activity
CO731_RS23665	COG0588	phosphoglycerate mutase activity
CO731_RS23675	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CO731_RS23685	COG0038	chloride channel
CO731_RS23730	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CO731_RS23740	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CO731_RS23745	COG0583	DNA-binding transcription factor activity
CO731_RS23750	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CO731_RS23755	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CO731_RS23760	COG0124	histidyl-tRNA synthetase
CO731_RS23775	COG2818	Glycosylase
CO731_RS23780	COG1376	ErfK ybiS ycfS ynhG family protein
CO731_RS23790	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CO731_RS23795	COG1376	ErfK ybiS ycfS ynhG family protein
CO731_RS23800	COG0247	lactate metabolic process
CO731_RS23820	COG0277	FAD linked oxidase domain protein
CO731_RS23865	COG1309	transcriptional regulator
CO731_RS23885	COG0583	DNA-binding transcription factor activity
CO731_RS23890	COG1570	exodeoxyribonuclease VII activity
CO731_RS23900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CO731_RS23905	COG1178	ABC-type Fe3 transport system permease component
CO731_RS23910	COG1840	ABC-type Fe3 transport system, periplasmic component
CO731_RS23915	COG2205	protein histidine kinase activity
CO731_RS23920	COG5490	Phasin protein
CO731_RS23960	COG0443	Heat shock 70 kDa protein
CO731_RS23980	COG1074	ATP-dependent DNA helicase activity
CO731_RS24025	COG2224	Isocitrate lyase
CO731_RS24045	COG0174	glutamine synthetase
CO731_RS24055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_RS24075	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CO731_RS24080	COG0363	glucosamine-6-phosphate deaminase activity
CO731_RS24085	COG0129	dihydroxy-acid dehydratase activity
CO731_RS24105	COG0488	(ABC) transporter
CO731_RS24120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CO731_RS24140	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CO731_RS24175	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CO731_RS24180	COG4149	molybdate abc transporter
CO731_RS24185	COG0725	ABC transporter, periplasmic molybdate-binding protein
CO731_RS24190	COG0730	response to heat
CO731_RS24195	COG0183	Belongs to the thiolase family
CO731_RS24200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CO731_RS24205	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CO731_RS24210	COG1414	Transcriptional regulator
CO731_RS24220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CO731_RS24395	COG1783	phage Terminase large subunit
CO731_RS24420	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CO731_RS24585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CO731_RS24595	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CO731_RS24600	COG5328	Belongs to the UPF0262 family
CO731_RS24610	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CO731_RS24615	COG0424	maF-like protein
CO731_RS24620	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CO731_RS24640	COG4974	Belongs to the 'phage' integrase family
CO731_RS24665	COG3706	GGDEF domain
CO731_RS24800	COG1802	Transcriptional regulator
CO731_RS24800	COG4626	Terminase
CO731_RS24850	COG0328	RNA-DNA hybrid ribonuclease activity
CO731_RS24915	COG0582	viral genome integration into host DNA
CO731_RS24925	COG3300	MHYT domain
CO731_RS24925	COG5001	Diguanylate cyclase
CO731_RS24935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_RS24940	COG2186	Transcriptional regulator
CO731_RS24975	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CO731_RS24980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_RS25005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CO731_RS25015	COG0251	oxidation-reduction process
CO731_RS25025	COG0765	amino acid transport
CO731_RS25030	COG0765	amino acid transport
CO731_RS25050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CO731_RS25055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO731_RS25060	COG1120	ATPase activity
CO731_RS25065	COG3585	molybdate ion transport
CO731_RS25070	COG1720	tRNA m6t6A37 methyltransferase activity
CO731_RS25080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_RS25085	COG4215	(ABC) transporter
CO731_RS25090	COG0765	amino acid transport
CO731_RS25095	COG3457	Alanine racemase
CO731_RS25100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_RS25110	COG0156	8-amino-7-oxononanoate synthase activity
CO731_RS25115	COG0436	Aminotransferase
CO731_RS25120	COG1970	mechanosensitive ion channel activity
CO731_RS25125	COG0784	Response regulator, receiver
CO731_RS25125	COG2205	protein histidine kinase activity
CO731_RS25145	COG0167	dihydroorotate dehydrogenase activity
CO731_RS25155	COG0123	including yeast histone deacetylase and acetoin utilization protein
CO731_RS25175	COG0717	Belongs to the dCTP deaminase family
CO731_RS25185	COG2967	ApaG domain
CO731_RS25195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CO731_RS25200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CO731_RS25210	COG0598	Magnesium transport protein CorA
CO731_RS25215	COG0704	Plays a role in the regulation of phosphate uptake
CO731_RS25220	COG5002	protein histidine kinase activity
CO731_RS25225	COG2326	polyphosphate kinase activity
CO731_RS25275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO731_RS25285	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CO731_RS25295	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CO731_RS25305	COG1024	Enoyl-CoA hydratase
CO731_RS25305	COG1250	3-hydroxyacyl-CoA dehydrogenase
CO731_RS25310	COG0183	Belongs to the thiolase family
CO731_RS25315	COG1960	acyl-CoA dehydrogenase activity
CO731_RS25325	COG1960	acyl-CoA dehydrogenase activity
CO731_RS25330	COG0789	Transcriptional regulator
CO731_RS25340	COG0730	response to heat
CO731_RS25355	COG1201	RNA secondary structure unwinding
CO731_RS25375	COG1793	dna ligase
CO731_RS25650	COG3422	double-strand break repair
CO731_RS25665	COG0444	Belongs to the ABC transporter superfamily
CO731_RS25670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS25680	COG0747	negative chemotaxis
CO731_RS25685	COG4608	Belongs to the ABC transporter superfamily
CO731_RS25690	COG0444	Belongs to the ABC transporter superfamily
CO731_RS25695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS25700	COG0601	transmembrane transport
CO731_RS25705	COG0747	negative chemotaxis
CO731_RS25710	COG0318	PFAM AMP-dependent synthetase and ligase
CO731_RS25720	COG0129	dihydroxy-acid dehydratase activity
CO731_RS25765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO731_RS25770	COG0166	Belongs to the GPI family
CO731_RS25780	COG0583	DNA-binding transcription factor activity
CO731_RS25785	COG2814	Major facilitator Superfamily
CO731_RS25790	COG0489	protein tyrosine kinase activity
CO731_RS25815	COG0583	DNA-binding transcription factor activity
CO731_RS25830	COG3383	formate dehydrogenase (NAD+) activity
CO731_RS25835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CO731_RS25845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CO731_RS25875	COG1349	DNA-binding transcription factor activity
CO731_RS25890	COG2340	Cysteine-rich secretory protein family
CO731_RS25895	COG0697	spore germination
CO731_RS25905	COG0402	S-adenosylhomocysteine deaminase activity
CO731_RS25910	COG1079	Belongs to the binding-protein-dependent transport system permease family
CO731_RS25920	COG4603	Belongs to the binding-protein-dependent transport system permease family
CO731_RS25930	COG3845	ABC transporter
CO731_RS25940	COG1132	(ABC) transporter
CO731_RS25945	COG1012	belongs to the aldehyde dehydrogenase family
CO731_RS25950	COG0288	reversible hydration of carbon dioxide
CO731_RS25965	COG1346	cytolysis
CO731_RS25985	COG1733	regulation of RNA biosynthetic process
CO731_RS26005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CO731_RS26010	COG0594	ribonuclease P activity
CO731_RS26015	COG0706	membrane insertase activity
CO731_RS26025	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CO731_RS26030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO731_RS26035	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CO731_RS26050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CO731_RS26065	COG3186	Phenylalanine-4-hydroxylase
CO731_RS26075	COG3706	GGDEF domain
CO731_RS26095	COG2171	N-acyltransferase activity
CO731_RS26100	COG3152	Membrane
CO731_RS26105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO731_RS26115	COG0101	tRNA pseudouridine synthase activity
CO731_RS26125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CO731_RS26135	COG0242	peptide deformylase activity
CO731_RS26175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CO731_RS26190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CO731_RS26195	COG3773	Cell wall hydrolase
CO731_RS26195	COG3409	Peptidoglycan-binding domain 1 protein
CO731_RS26205	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CO731_RS26210	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CO731_RS26225	COG2816	NAD+ diphosphatase activity
CO731_RS26230	COG0456	acetyltransferase
CO731_RS26230	COG1846	Transcriptional regulator
CO731_RS26235	COG4106	trans-aconitate 2-methyltransferase activity
CO731_RS26240	COG1605	Chorismate mutase
CO731_RS26240	COG0077	Prephenate dehydratase
CO731_RS26245	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CO731_RS26250	COG3474	cytochrome
CO731_RS26255	COG4166	transmembrane transport
CO731_RS26260	COG4166	transmembrane transport
CO731_RS26265	COG4174	ABC transporter (Permease)
CO731_RS26270	COG4239	(ABC) transporter, permease
CO731_RS26280	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
CO731_RS26285	COG4172	Belongs to the ABC transporter superfamily
CO731_RS26305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CO731_RS26340	COG4964	Belongs to the GSP D family
CO731_RS26375	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CO731_RS26380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CO731_RS26385	COG1024	Enoyl-CoA hydratase
CO731_RS26390	COG0268	Binds directly to 16S ribosomal RNA
CO731_RS26400	COG4208	sulfate ABC transporter
CO731_RS26405	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_RS26410	COG3842	ATPase activity
CO731_RS26425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CO731_RS26435	COG0604	alcohol dehydrogenase
CO731_RS26445	COG0277	FAD linked oxidase domain protein
CO731_RS26455	COG3831	ATPase activity
CO731_RS26460	COG1192	Involved in chromosome partitioning
CO731_RS26465	COG1475	DNA binding
CO731_RS26470	COG1414	Transcriptional regulator
CO731_RS26515	COG0765	amino acid transport
CO731_RS26520	COG0765	amino acid transport
CO731_RS26540	COG1126	abc transporter atp-binding protein
CO731_RS26545	COG0252	asparaginase activity
CO731_RS26550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO731_RS26560	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO731_RS26565	COG1177	transmembrane transport
CO731_RS26570	COG3842	ATPase activity
CO731_RS26580	COG0196	riboflavin kinase activity
CO731_RS26590	COG0625	glutathione transferase activity
CO731_RS26595	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CO731_RS26600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CO731_RS26605	COG2368	4-hydroxyphenylacetate
CO731_RS26620	COG0583	DNA-binding transcription factor activity
CO731_RS26625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO731_RS26630	COG1027	Aspartate ammonia-lyase
CO731_RS26645	COG0242	peptide deformylase activity
CO731_RS26660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CO731_RS26670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_RS26675	COG0431	NADPH-dependent FMN reductase
CO731_RS26695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CO731_RS26725	COG3593	DNA synthesis involved in DNA repair
CO731_RS26730	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CO731_RS26740	COG0443	Heat shock 70 kDa protein
CO731_RS26770	COG1177	transmembrane transport
CO731_RS26780	COG2072	flavoprotein involved in K transport
CO731_RS26795	COG3620	sequence-specific DNA binding
CO731_RS26805	COG4948	Mandelate Racemase Muconate Lactonizing
CO731_RS26810	COG2186	Transcriptional regulator
CO731_RS26820	COG1129	ABC transporter
CO731_RS26830	COG2017	converts alpha-aldose to the beta-anomer
CO731_RS26835	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS26845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO731_RS26890	COG1596	polysaccharide export
CO731_RS26895	COG0489	protein tyrosine kinase activity
CO731_RS26895	COG3206	protein involved in exopolysaccharide biosynthesis
CO731_RS26910	COG0438	transferase activity, transferring glycosyl groups
CO731_RS26920	COG0492	ferredoxin-NADP+ reductase activity
CO731_RS26925	COG1522	sequence-specific DNA binding
CO731_RS26935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CO731_RS26935	COG3453	Protein conserved in bacteria
CO731_RS26945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_RS26950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CO731_RS26960	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS26975	COG0302	gtp cyclohydrolase
CO731_RS26990	COG4948	Mandelate Racemase Muconate Lactonizing
CO731_RS27010	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CO731_RS27025	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CO731_RS27040	COG1942	4-Oxalocrotonate Tautomerase
CO731_RS27055	COG0154	amidase activity
CO731_RS27060	COG0402	S-adenosylhomocysteine deaminase activity
CO731_RS27075	COG0523	cobalamin synthesis protein
CO731_RS27085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_RS27090	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CO731_RS27110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CO731_RS27120	COG1957	nucleoside hydrolase
CO731_RS27125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_RS27145	COG0045	succinate-CoA ligase (ADP-forming) activity
CO731_RS27150	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CO731_RS27155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO731_RS27160	COG2379	hydroxypyruvate reductase
CO731_RS27170	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CO731_RS27175	COG2218	PFAM glutamate synthase alpha subunit domain protein
CO731_RS27180	COG0069	glutamate synthase activity
CO731_RS27190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO731_RS27200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO731_RS27200	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO731_RS27215	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CO731_RS27220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CO731_RS27275	COG0531	amino acid
CO731_RS27300	COG1522	sequence-specific DNA binding
CO731_RS27305	COG2826	transposase and inactivated derivatives, IS30 family
CO731_RS27315	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CO731_RS27325	COG0625	glutathione transferase activity
CO731_RS27335	COG3842	ATPase activity
CO731_RS27340	COG1840	ABC-type Fe3 transport system, periplasmic component
CO731_RS27350	COG1012	belongs to the aldehyde dehydrogenase family
CO731_RS27360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CO731_RS27365	COG1283	sodium-dependent phosphate transmembrane transporter activity
CO731_RS27370	COG0583	DNA-binding transcription factor activity
CO731_RS27380	COG3795	YCII-related domain
CO731_RS27385	COG0488	(ABC) transporter
CO731_RS27415	COG1349	DNA-binding transcription factor activity
CO731_RS27430	COG4638	Rieske (2fe-2S)
CO731_RS27445	COG3347	Dehydrogenase
CO731_RS27445	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS27460	COG1129	ABC transporter
CO731_RS27465	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_RS27470	COG1172	Belongs to the binding-protein-dependent transport system permease family
CO731_RS27485	COG1070	Carbohydrate kinase
CO731_RS27495	COG4952	isomerase
CO731_RS27500	COG3254	rhamnose metabolic process
CO731_RS27505	COG0235	Class ii aldolase
CO731_RS27515	COG0444	Belongs to the ABC transporter superfamily
CO731_RS27520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO731_RS27525	COG0601	transmembrane transport
CO731_RS27530	COG0747	negative chemotaxis
CO731_RS27545	COG1473	amidohydrolase
CO731_RS27550	COG1473	amidohydrolase
CO731_RS27560	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CO731_RS27565	COG2894	cell division
CO731_RS27570	COG0850	regulation of cytokinetic process
CO731_RS27575	COG2826	transposase and inactivated derivatives, IS30 family
CO731_RS27600	COG0583	DNA-binding transcription factor activity
CO731_RS27610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO731_RS27620	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CO731_RS27630	COG0154	amidase activity
CO731_RS27640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CO731_RS27655	COG3845	ABC transporter
CO731_RS27665	COG1079	Belongs to the binding-protein-dependent transport system permease family
CO731_RS27695	COG1271	oxidase subunit
CO731_RS27700	COG1294	oxidase, subunit
CO731_RS27715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO731_RS27725	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CO731_RS27755	COG3483	tryptophan 2,3-dioxygenase activity
CO731_RS27780	COG0411	ABC transporter
CO731_RS27795	COG4120	Belongs to the binding-protein-dependent transport system permease family
CO731_RS27800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO731_RS27810	COG1802	Transcriptional regulator
CO731_RS27815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CO731_RS27830	COG1028	Short-chain dehydrogenase reductase Sdr
CO731_RS27835	COG1024	Enoyl-CoA hydratase
CO731_RS27840	COG1960	acyl-CoA dehydrogenase activity
CO731_RS27855	COG1024	Enoyl-CoA hydratase
CO731_RS27855	COG1250	3-hydroxyacyl-CoA dehydrogenase
CO731_RS27865	COG0165	Argininosuccinate lyase
CO731_RS27870	COG0395	ABC-type sugar transport system, permease component
CO731_RS27875	COG1175	transmembrane transport
CO731_RS27880	COG2182	Extracellular solute-binding protein
CO731_RS27885	COG1940	carbohydrate kinase activity
CO731_RS27900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO731_RS27905	COG4521	taurine ABC transporter
CO731_RS27910	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CO731_RS27915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO731_RS27930	COG0028	Belongs to the TPP enzyme family
CO731_RS27935	COG2855	membrane
CO731_RS27950	COG2814	Major facilitator Superfamily
CO731_RS27965	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CO731_RS27970	COG0583	DNA-binding transcription factor activity
CO731_RS27975	COG0626	cystathionine gamma-synthase activity
CO731_RS27990	COG0765	amino acid transport
CO731_RS28015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CO731_RS28030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CO731_RS28055	COG0179	Fumarylacetoacetate (FAA) hydrolase
CO731_RS28125	COG4974	Belongs to the 'phage' integrase family
CO731_RS28130	COG0582	viral genome integration into host DNA
CO731_RS28135	COG4974	Belongs to the 'phage' integrase family
CO731_RS28165	COG0582	viral genome integration into host DNA
CO731_RS28215	COG3504	Conjugal transfer protein
CO731_RS28220	COG3701	Conjugal transfer protein
CO731_RS28225	COG3846	protein secretion by the type IV secretion system
CO731_RS28235	COG5314	conjugation
CO731_RS28240	COG3451	type IV secretory pathway VirB4
CO731_RS28250	COG3838	Conjugal transfer protein Trbc
CO731_RS28255	COG4962	Type ii secretion system protein e
CO731_RS28260	COG1192	Involved in chromosome partitioning
CO731_RS28265	COG1475	DNA binding
CO731_RS28270	COG0640	Transcriptional regulator
CO731_RS28275	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CO731_RS28280	COG3657	addiction module killer protein
CO731_RS28285	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CO731_RS28305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CO731_RS28415	COG3077	Addiction module antitoxin, RelB DinJ family
CO731_RS28420	COG3041	Addiction module toxin RelE StbE family
CO731_RS28450	COG4962	Type ii secretion system protein e
CO731_RS28455	COG3838	Conjugal transfer protein Trbc
CO731_RS28460	COG5268	conjugation
CO731_RS28485	COG0318	PFAM AMP-dependent synthetase and ligase